Detecting and characterising antibiotic resistance
Antibiotic resistance is recognised by the World Health Organisation as one of the greatest threats to human health. Research into the evolution, mechanisms and detection of antibiotic resistance has the potential to improve the use and selection of antibiotics to provide better and more cost-effective treatment of some important infectious diseases.
The Infection and Molecular Diagnostics Group is broadly involved in research on infectious diseases within the context of microbiology and molecular biology and covers both pure mechanistic biology and diagnostic applications.
Major Achievements and Grants
Over the last 10 years we have received over $300 000 in external research grant funding. Our most significant achievements relate to antibiotic resistance in H. influenzae, where we have discovered a number of previously unrecognised mechanisms of resistance, developed a number of new molecular tests to better detect the resistance, and most notably unravelled the molecular evolution of the most common mechanism of antibiotic resistance in this organism.
Current Research Projects
- Acquired macrolide resistance genes in Haemophilus influenzae.
- Preliminary development of a probiotic to minimise respiratory infection with Haemophilus influenzae.
- Invasion of respiratory epithelial cells by Haemophilus influenzae.
Current and Past Collaborators
- Dr Louise Roddam and the Tasmanian Cystic Fibrosis Research Group (University of Tasmania, Hobart)
- Dr Maria Paula Bajanca-Lavado (National Institute of Health, Portugal)
- Dr Bulent Bozdogan (Adnan Mendres University, Turkey)
- Dr Niels Nørskov-Lauritsen (Aarhus University, Denmark)