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Transient Receptor Vanilloid 1 (TRPV1) in Haematological Malignancies
Bachelor degree in Medical Laboratory Sciences (JUST, Jordan)
Master degree in Medical Laboratory Sciences/ Haematology and Blood Banking (JUST, Jordan).
Vanilloids are natural substances found in most spicy food and capsaicin is one such vanilloid present in 'hot chilli pepper'. Transient receptor potential vanilloids 1 (TRPV1) is the receptor for capsaicin and was described originally as an afferent neuron nociceptor. Capsaicin has been found to have an anticancer properties; it promotes apoptosis and inhibits cell proliferation in cancer cells. We are investigating the effect of capsaicin on haematological malignant cells and the expression and role of TRPV1 in capsaicin-induced cell activity.
Effect of capsaicin on metabolic activity of the haematological malignant cell lines, THP-1, U266 and U937 cells.
Authorised by the Head of Human Life Sciences
15 October, 2012