University of Tasmania, Australia

Senior Lecturer

Teaching Responsibilities

Dr Holloway is involved in teaching Biochemistry and Molecular Biology to second- and third-year students.

Units

• CBA265 - Molecular Biology in Health & Disease

Publications

• Poke, F. S., Qadi, A., & Holloway, A. F. (2010). Reversing aberrant methylation patterns in cancer. Current Medicinal Chemistry, 17(13), 1246-1254.
• Oakford, P. C., James, S. R., Qadi, A., West, A. C., Ray, S. N., Bert, A. G., Cockerill, P. N., & Holloway, A. F. (2010). Transcriptional and epigenetic regulation of the GM-CSF promoter by RUNX1. Leukemia Research, 34(9), 1203–1213.
• Brettingham-Moore, K. H., Sprod, O. R., Chen, X., Oakford, P. C., Shannon, M. F., & Holloway, A. F. (2008). Determinants of a transcriptionally competent environment at the GM-CSF promoter. Nucleic Acids Research, 36(8), 2639-2653.
• Holloway, A. F., & Oakford, P. C. (2007). Targeting epigentic modifiers in cancer. Current Medicinal Chemistry, 14(24), 2540-2547.
• Shannon, M. F., Chen, X., Brettingham-Moore, K. H., & Holloway, A. F. (2006). Chromatin remodelling: Distinct molecular events during differentiation and activation of T cells. Current Immunology Reviews, 2(3), 273-289.

Web Access Research Portal (WARP)

Additional Information

Research Interests

Dr Holloway is a molecular biologist interested in the regulation of gene expression. Her research is primarily focused on understanding how genes are switched on and off in response to specific cellular signals.

This research employs a range of molecular and cell biology based techniques to investigate the molecular mechanisms involved in switching on gene expression in cells of the immune system.

A current project is investigating the cellular signals and factors involved in switching on expression of the cytokine GM-CSF in T cells. Disruption of normal gene expression programs is a contributing factor in a range of immune diseases including certain leukemias, asthma and arthritis.