University of Tasmania, Australia

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Kate Brettingham-Moore

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Dr Kate Brettingham-Moore

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Lecturer in Biochemistry

BSc(Hons), PhD

Kate Brettingham-Moore

Contact Details

Contact Campus Hobart CBD Campuses
Building Medical Science 1
Room Reference 414 (Level 4)
Telephone +61 3 6226 4609
Email Kate.BrettinghamMoore@utas.edu.au

General Responsibilities

Dr Brettingham-Moore completed her PhD at the University of Tasmania in 2007, then spent two years at the Murdoch Childrens Research Institute in Melbourne, researching the role of transcription in centromere formation. This was followed by a two year stint at the Peter MacCallum Cancer Centre in Melbourne, investigating whether transcriptional biomarkers in pretreatment cancer biopsies could be used to predict response to chemoradiotherapy.

Teaching Responsibilities

Units Taught

Publications

  • Brettingham-Moore, K. H., Duong, C. P., Greenawalt, D. M., Heriot, A. G., Ellul, J., Dow, C., Murray, W. K., Hicks, R., Tjandra, J., Chao, M., Bui, A., Lim Joon, D., Thomas, R. J. S. & Phillips, W. A. (2011). Pretreatment transcriptional profiling for predicting response to neoadjuvant chemoradiotherapy in rectal adenocarcinoma, Clinical Cancer Research. doi: 10.1158/1078-0432.CCR-10-2915
  • Brettingham-Moore, K. H., Duong, C. P., Heriot, A. G., Thomas, R. J. S. & Phillips, W. A. (2010). Using gene expression profiling to predict response to therapy in gastrointestinal cancers - the promise and the perils. Annals of Surgical Oncology. doi: 10.1245/s10434-010-1433-1
  • Chueh, A. C., Northrop, E. L., Brettingham-Moore, K. H., Choo, K. H., & Wong, L. H. (2009). LINE retrotransposon RNA is an essential structural and functional epigenetic component of a core neocentromeric chromatin. PLoS Genetics, 5(2). doi: 10.1371/annotation/3b497aec-b7d3-442e-9086-751251f649dd
  • Brettingham-Moore, K. H., Sprod, O. R., Chen, X., Oakford, P., Shannon, M. F. & Holloway, A. F. (2008). Determinants of a transcriptionally competent environment at the GM-CSF promoter. Nucleic Acids Research, 36(8), 2639-2653.
  • Wong, L. H., Brettingham-Moore, K. H., Chan, L., Quach, J. M., Anderson, M. A., Northrop, E. L., Hannan, R., Saffery, R., Shaw, M. L., Williams, E. & Choo, K. H. (2007). Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere. Genome Research, 17(8), 1146-1160.
  • Shannon, M. F., Chen, X., Brettingham-Moore, K. H. & Holloway, A. F. (2006). Chromatin remodelling: Distinct molecular events during differentiation and activation of T cells. Current Immunology Reviews, 2(3), 273-289.
  • Brettingham-Moore, K. H., Rao, S., Juelich, T., Shannon, M. F. & Holloway, A. F. (2005). GM-CSF promoter chromatin remodelling and gene transcription display distinct signal and transcription factor requirements. Nucleic Acids Research, 33(1), 225-234.

Web Access Research Portal (WARP)

Additional Information

Research Interests

Dr Brettingham-Moore's research interests are in transcription, and in particular identifying transcriptional/molecular biomarkers, which may hold predictive value for helping to tailor cancer treatment.