Profiles

Jason A Smith

UTAS Home Assoc Prof Jason A Smith
Jason Smith

Jason A Smith

Senior Lecturer

Room 435, Chemistry Building, Sandy Bay Campus

+61 3 6226 2182 (phone)

+61 3 6226 2858 (fax)

Jason.Smith@utas.edu.au

Dr Jason A Smith is a Senior Lecturer in Chemistry and carries out research in the area of Organic Chemistry, designing and synthesising new molecules for Drug Discovery.  He studies the role of organic molecules in living systems, such as determining the role of plant hormones in plant health and crop yield.  Organic Chemistry plays a major role in improving society by developing new drugs to combat disease and understanding chemical processes of plants to improve food security.

Career summary

Qualifications

  • PhD: Flinders University (1997) 
  • BSc (Hons): Flinders University (1993)
  • BSc: Flinders University (1992)

Biography

Jason is a graduate of Flinders University of South Australia where he obtained both his BSc (Hons) and PhD. He has carried out post-doctoral research at Texas A&M (with Nobel Laureate Prof Sir Derek HR Barton) and at Australian National University (Prof Martin Banwell). In 1999 he received an AMRAD postdoctoral award and the RACI Athel Beckwith Lectureship in 2005.

Memberships

Committee associations

  • Royal Australian Chemical Institute

Teaching

Organic Chemistry, Medicinal Chemistry, Natural Products, Reaction Mechanisms, Spectroscopy, Biosynthesis

Teaching expertise

Jason's area of teaching is in organic chemistry and includes the structure, shape and reactivity of organic molecules and methods for determining chemical structure.  The role and connections of organic chemistry to other disciplines is highlighted in pharmaceutical sciences, medical applications, drug design and the role of organic molecules in nature and how nature produces important compounds.

Teaching responsibility

General organic chemistry and biosynthesis of alkaloids

View more on AssocProf Jason Smith in WARP

Expertise

Jason's research activities focus on the development of new synthetic methodology and its application to the synthesis of biologically active or structurally complex molecules. This includes exploiting pyrrole as a molecular template for the rapid construction of alkaloids. Other research areas involve the development of new methods for carrying out demanding organic transformations, the determination of organic reaction mechanisms, applications in biosynthesis and the synthesis of potential drug candidates for particular diseases.  A recent development in our laboratories has been the development of pressured hot water extraction (PHWE) for natural product isolation.  Jason also has an active research program on the synthesis and roles of plant hormones.

Awards

  • AMRAD postdoctoral award – 1999
  • RACI Athel Beckwith Lectureship - 2005

Current projects

Research Fields

  • Organic Chemical Synthesis (030503)
  • Plant Physiology (060705)
  • Natural Products Chemistry (030502)
  • Separation Science (030108)
  • Transition Metal Chemistry (030207)
  • Organic Chemistry (030599)
  • Free Radical Chemistry (030501)
  • Chemical Sciences (039999)
  • Structural Biology (incl. Macromolecular Modelling) (060112)
  • Algebra and Number Theory (010101)
  • Plant Developmental and Reproductive Biology (060703)
  • Medicinal and Biomolecular Chemistry (030499)
  • Biologically Active Molecules (030401)
  • Forestry Pests, Health and Diseases (070505)
  • Organometallic Chemistry (039904)
  • Physical Organic Chemistry (030505)
  • Catalysis and Mechanisms of Reactions (030601)
  • Pharmaceutical Sciences (111504)
  • Instrumental Methods (excl. Immunological and Bioassay Methods) (030105)
  • Genomics (060408)
  • Infectious Diseases (110309)
  • Pharmacology and Pharmaceutical Sciences (111599)
  • Tree Nutrition and Physiology (070508)
  • Ophthalmology (111301)
  • Basic Pharmacology (111501)
  • Invertebrate Biology (060808)
  • Industrial Chemistry (039903)
  • Medical Biotechnology (100499)
  • Immunological and Bioassay Methods (030104)
  • Analytical Spectrometry (030101)
  • Main Group Metal Chemistry (030204)
  • f-Block Chemistry (030202)
  • Plant Cell and Molecular Biology (060702)
  • Conservation and Biodiversity (050202)

Research Impact

  • Expanding Knowledge in the Chemical Sciences (970103)
  • Infectious Diseases (920109)
  • Expanding Knowledge in the Biological Sciences (970106)
  • Hardwood Plantations (820101)
  • Expanding Knowledge in the Environmental Sciences (970105)
  • Human Pharmaceutical Treatments (e.g. Antibiotics) (860803)
  • Air Force (810101)
  • Environmentally Sustainable Plant Production (829899)
  • Organic Industrial Chemicals (excl. Resins, Rubber and Plastics) (860604)
  • Rice (820402)
  • Horticultural Crops (820299)
  • Human Pharmaceutical Products (860899)
  • Control of Pests, Diseases and Exotic Species in Urban and Industrial Environments (960411)
  • Grain Legumes (820503)
  • Industrial Chemicals and Related Products (860699)
  • Hearing, Vision, Speech and Their Disorders (920107)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Summer Grains and Oilseeds (820499)
  • Environment (969999)
  • Animal Protection Chemicals (860701)
  • Bakery Products (860101)
  • Scientific Instruments (861503)
  • Veterinary Pharmaceutical Treatments (e.g. Antibiotics) (860903)
  • Plant Production and Plant Primary Products (829999)
  • Environmentally Sustainable Manufacturing (869899)
  • Industrial Instruments (861501)
  • Cancer and Related Disorders (920102)
  • Vegetables (820215)
  • Diagnostic Methods (920203)
  • Environmentally Sustainable Mineral Resource Activities (849899)

Publications

Total publications

61

Highlighted publications

(9 outputs)
YearTypeCitationAltmetrics
2015Journal ArticleJust J, Deans BJ, Olivier WJ, Paull B, Bissember AC, et al., 'New method for the rapid extraction of natural products: efficient isolation of shikimic acid from star anise', Organic Letters, 17, (10) pp. 2428-2430. ISSN 1523-7060 (2015) [Refereed Article]

DOI: 10.1021/acs.orglett.5b00936 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Just J; Deans BJ; Paull B; Bissember AC

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2015Journal ArticleJust J, Jordan TB, Paull B, Bissember AC, Smith JA, 'Practical isolation of polygodial from Tasmannia lanceolata: a viable scaffold for synthesis', Organic and Biomolecular Chemistry, 13, (46) pp. 11200-11207. ISSN 1477-0520 (2015) [Refereed Article]

DOI: 10.1039/c5ob01573a [eCite] [Details]

Citations: Scopus - 1

Co-authors: Just J; Jordan TB; Paull B; Bissember AC

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2013Journal ArticleHoward JK, Hyland CJT, Just J, Smith JA, 'Controlled oxidation of pyrroles: synthesis of highly functionalized γ-lactams', Organic Letters, 15, (7) pp. 1714-1717. ISSN 1523-7060 (2013) [Refereed Article]

DOI: 10.1021/ol400491p [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

Co-authors: Howard JK; Hyland CJT; Just J

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2010Journal ArticleTivendale ND, Davies NW, Molesworth PP, Davidson SE, Smith JA, et al., 'Reassessing the role of N-Hydroxytryptamine in auxin biosynthesis', Plant Physiology, 154, (4) pp. 1957-1965. ISSN 0032-0889 (2010) [Refereed Article]

DOI: 10.1104/pp.110.165803 [eCite] [Details]

Citations: Scopus - 34Web of Science - 30

Co-authors: Tivendale ND; Davies NW; Molesworth PP; Davidson SE; Lowe EK; Reid JB; Ross JJ

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2008Journal ArticleAmos RIJ, Gourlay BS, Schiesser CH, Smith Jason, Yates BF, 'A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid', Chemical Communications, 2008, (14) pp. 1695-1697. ISSN 1359-7345 (2008) [Refereed Article]

DOI: 10.1039/b719570b [eCite] [Details]

Citations: Scopus - 18Web of Science - 19

Co-authors: Amos RIJ; Gourlay BS; Yates BF

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2008Journal ArticleGourlay BS, Ryan JH, Smith Jason, 'Knorr-Rabe partial reduction of pyrroles: Application to the synthesis of indolizidine alkaloids', Beilstein Journal of Organic Chemistry, 4, (3) EJ ISSN 1860-5397 (2008) [Refereed Article]

DOI: 10.1186/1860-5397-4-3 [eCite] [Details]

Citations: Scopus - 1Web of Science - 7

Co-authors: Gourlay BS

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2006Journal ArticleBolton K, Canty AJ, Deverell JA, Guijt RM, Hilder EF, et al., 'Macroporous monolith supports for continuous flow capillary microreactors', Tetrahedron Letters, 47, (52) pp. 9321-9324. ISSN 0040-4039 (2006) [Refereed Article]

DOI: 10.1016/j.tetlet.2006.10.113 [eCite] [Details]

Citations: Scopus - 33Web of Science - 31

Co-authors: Bolton K; Canty AJ; Deverell JA; Guijt RM; Hilder EF; Rodemann T

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2006Journal ArticleGourlay BS, Molesworth PP, Ryan JH, Smith JA, 'A new and high yielding synthesis of unstable pyrroles via a modified Clauson-Kaas reaction', Tetrahedron Letters, 47, (5) pp. 799-801. ISSN 0040-4039 (2006) [Refereed Article]

DOI: 10.1016/j.tetlet.2005.11.104 [eCite] [Details]

Citations: Scopus - 23Web of Science - 23

Co-authors: Gourlay BS; Molesworth PP

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2006Journal ArticleSmith JA, Ng M, White J, 'The regioselective synthesis of aryl pyrroles', Organic and Biomolecular Chemistry, 4, (12) pp. 2477-2482. ISSN 1477-0520 (2006) [Refereed Article]

DOI: 10.1039/b604692d [eCite] [Details]

Citations: Scopus - 28Web of Science - 29

Co-authors: Ng M

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Journal Article

(49 outputs)
YearCitationAltmetrics
2016Cook SD, Nichols DS, Smith J, Chourey PS, McAdam EL, et al., 'Auxin biosynthesis: are the indole-3-acetic acid and phenylacetic acid biosynthesis pathways mirror images?', Plant Physiology, 171, (2) pp. 1230-1241. ISSN 0032-0889 (2016) [Refereed Article]

DOI: 10.1104/pp.16.00454 [eCite] [Details]

Co-authors: Cook SD; Nichols DS; McAdam EL; Quittenden L; Ross JJ

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2016Foo E, Blake SN, Fisher BJ, Smith JA, Reid JB, 'The role of strigolactones during plant interactions with the pathogenic fungus Fusarium oxysporum', Planta, 243, (6) pp. 1387-1396. ISSN 0032-0935 (2016) [Refereed Article]

DOI: 10.1007/s00425-015-2449-3 [eCite] [Details]

Co-authors: Foo E; Blake SN; Fisher BJ; Reid JB

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2016Just J, Bunton GL, Deans BJ, Murray NL, Bissember AC, et al., 'Extraction of eugenol from cloves using an unmodified household espresso machine: an alternative to traditional steam-distillation', Journal of Chemical Education, 93, (1) pp. 213-216. ISSN 0021-9584 (2016) [Refereed Article]

DOI: 10.1021/acs.jchemed.5b00476 [eCite] [Details]

Citations: Web of Science - 1

Co-authors: Just J; Bunton GL; Deans BJ; Bissember AC

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2016Howard JK, Rihak KJ, Bissember AC, Smith JA, 'The oxidation of pyrrole', Chemistry: An Asian Journal, 11, (2) pp. 155-167. ISSN 1861-4728 (2016) [Refereed Article]

DOI: 10.1002/asia.201500659 [eCite] [Details]

Citations: Scopus - 2Web of Science - 3

Co-authors: Rihak KJ; Bissember AC

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2015Bromhead LJ, Smith J, McErlean CSP, 'Chemistry of the synthetic strigolactone mimic GR24', Australian Journal of Chemistry, 68, (8) pp. 1221-1227. ISSN 0004-9425 (2015) [Refereed Article]

DOI: 10.1071/CH15298 [eCite] [Details]

Citations: Scopus - 1Web of Science - 2

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2015Just J, Deans BJ, Olivier WJ, Paull B, Bissember AC, et al., 'New method for the rapid extraction of natural products: efficient isolation of shikimic acid from star anise', Organic Letters, 17, (10) pp. 2428-2430. ISSN 1523-7060 (2015) [Refereed Article]

DOI: 10.1021/acs.orglett.5b00936 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Just J; Deans BJ; Paull B; Bissember AC

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2015Just J, Jordan TB, Paull B, Bissember AC, Smith JA, 'Practical isolation of polygodial from Tasmannia lanceolata: a viable scaffold for synthesis', Organic and Biomolecular Chemistry, 13, (46) pp. 11200-11207. ISSN 1477-0520 (2015) [Refereed Article]

DOI: 10.1039/c5ob01573a [eCite] [Details]

Citations: Scopus - 1

Co-authors: Just J; Jordan TB; Paull B; Bissember AC

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2015Tivendale ND, Davies NW, Horne J, Ross JJ, Smith JA, 'Analysis of the enol-keto tautomers of indole-3-pyruvic acid', Australian Journal of Chemistry, 68, (2) pp. 345-348. ISSN 0004-9425 (2015) [Refereed Article]

DOI: 10.1071/CH14343 [eCite] [Details]

Co-authors: Tivendale ND; Davies NW; Horne J; Ross JJ

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2015Abel S-AG, Olivier WJ, Pederson RL, Bissember AC, Smith JA, 'Complete stereocontrol in the synthesis of harmonine and novel analogues facilitated by a Grubbs Z-selective cross-metathesis catalysis', Australian Journal of Chemistry, 68, (12) pp. 1815-1820. ISSN 0004-9425 (2015) [Refereed Article]

DOI: 10.1071/CH15397 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Abel S-AG; Bissember AC

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2015Gueven N, Woolley K, Smith J, 'Border between natural product and drug: comparison of the related benzoquinones idebenone and coenzyme Q10', Redox Biology, 4 pp. 289-295. ISSN 2213-2317 (2015) [Refereed Article]

DOI: 10.1016/j.redox.2015.01.009 [eCite] [Details]

Citations: Scopus - 7

Co-authors: Woolley K

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2014Deans RM, Gardiner MG, Horne J, Hung AC, Hyland CJT, et al., 'Isolation and characterization of 1β-Acetoxypolygodial from Tasmannia Lanceolata', Asian Journal of Organic Chemistry, 3, (11) pp. 1193-1196. ISSN 2193-5807 (2014) [Refereed Article]

DOI: 10.1002/ajoc.201402105 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Deans RM; Gardiner MG; Horne J; Hung AC; Hyland CJT; Just J

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2014Howard JK, Amin C, Lainhart B, Smith JA, Rimington J, et al., 'Synthesis of nitrogen-substituted methylenecyclopropanes by strain-driven overman rearrangement of cyclopropenylmethyl trichloroacetimidates', The Journal of Organic Chemistry, 79, (17) pp. 8462-8468. ISSN 0022-3263 (2014) [Refereed Article]

DOI: 10.1021/jo501423u [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Howard JK

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2014Abel SAG, Eglinton MO, Howard JK, Hunt DJ, Prager RH, et al., 'Synthesis of heterocyclic-fused imidazoles by pyrolysis of N-heterocyclic isoxazol-5(2H)-ones', Australian Journal of Chemistry, 67, (9) pp. 1228-1233. ISSN 0004-9425 (2014) [Refereed Article]

DOI: 10.1071/CH14119 [eCite] [Details]

Citations: Scopus - 1Web of Science - 2

Co-authors: Abel SAG; Howard JK

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2013Ferrins L, Rahmani R, Sykes ML, Jones AJ, Avery VM, et al., '3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis', European Journal of Medicinal Chemistry, 66 pp. 450-465. ISSN 0223-5234 (2013) [Refereed Article]

DOI: 10.1016/j.ejmech.2013.05.007 [eCite] [Details]

Citations: Scopus - 8

Co-authors: Hyland C

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2013Howard JK, Hyland CJT, Just J, Smith JA, 'Controlled oxidation of pyrroles: synthesis of highly functionalized γ-lactams', Organic Letters, 15, (7) pp. 1714-1717. ISSN 1523-7060 (2013) [Refereed Article]

DOI: 10.1021/ol400491p [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

Co-authors: Howard JK; Hyland CJT; Just J

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2013Amos RIJ, Gourlay BS, Yates BF, Schiesser CH, Lewis TW, et al., 'Mechanistic investigation of the oxidation of hydrazides: implications for the activation of the TB drug isoniazid', Organic and Biomolecular Chemistry, 11, (1) pp. 170-176. ISSN 1477-0520 (2013) [Refereed Article]

DOI: 10.1039/c2ob26419f [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Amos RIJ; Gourlay BS; Yates BF; Lewis TW

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2012Ross JJ, Tivendale ND, Davidson SE, Reid JB, Davies NW, et al., 'A mutation affecting the synthesis of 4-chloroindole-3-acetic acid', Plant Signalling & Behavior, 7, (12) pp. 1533-1536. ISSN 1559-2316 (2012) [Refereed Article]

DOI: 10.4161/psb.22319 [eCite] [Details]

Citations: Scopus - 1

Co-authors: Ross JJ; Tivendale ND; Davidson SE; Reid JB; Davies NW; Quittenden LJ

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2012Tivendale ND, Davidson SE, Davies NW, Smith JA, Dalmais M, et al., 'Biosynthesis of the halogenated auxin, 4-chloroindole-3-acetic acid', Plant Physiology, 159, (3) pp. 1055-1063. ISSN 0032-0889 (2012) [Refereed Article]

DOI: 10.1104/pp.112.198457 [eCite] [Details]

Citations: Scopus - 20Web of Science - 20

Co-authors: Tivendale ND; Davidson SE; Davies NW; Quittenden LJ; Bala RK; Horne J; Reid JB; Ross JJ

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2011Amos RIJ, Smith JA, Yates BF, Schiesser CH, 'Acyl radical addition to benzene and related systems - a computational study', Tetrahedron, 66, (38) pp. 7600-7604. ISSN 0040-4020 (2011) [Refereed Article]

DOI: 10.1016/j.tet.2010.07.041 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Amos RIJ; Yates BF

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2011Deverell JA, Rodemann T, Smith JA, Canty AJ, Guijt RM, 'UV initiated formation of polymer monoliths in glass and polymer microreactors', Sensors and Actuators B, 155, (1) pp. 388-396. ISSN 0925-4005 (2011) [Refereed Article]

DOI: 10.1016/j.snb.2010.11.020 [eCite] [Details]

Citations: Scopus - 14Web of Science - 16

Co-authors: Deverell JA; Rodemann T; Canty AJ; Guijt RM

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2011You HT, Grosse AC, Howard JK, Hyland CJT, Just J, et al., 'Chemoselective reduction of 2-acyl-N-sulfonylpyrroles: Synthesis of 3-pyrrolines and 2-alkylpyrroles', Organic & Biomolecular Chemistry, 9, (10) pp. 3948-3953. ISSN 1477-0520 (2011) [Refereed Article]

DOI: 10.1039/c1ob05111c [eCite] [Details]

Citations: Scopus - 4Web of Science - 3

Co-authors: Grosse AC; Howard JK; Hyland CJT; Just J; Molesworth PP

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2010Davies NW, Smith JA, Molesworth PP, Ross JJ, 'Hydrogen/deuterium exchange on aromatic rings during atmospheric pressure chemical ionization mass spectrometry ', Rapid Communications in Mass Spectrometry, 24, (7) pp. 1105-1110. ISSN 1097-0231 (2010) [Refereed Article]

DOI: 10.1002/rcm.4488 [eCite] [Details]

Citations: Scopus - 15Web of Science - 15

Co-authors: Davies NW; Molesworth PP; Ross JJ

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2010Kazarian AA, Smith JA, Hilder EF, Breadmore MC, Quirino JP, et al., 'Development of a novel fluorescent tag O-2-[aminoethyl]fluorescein for the electrophoretic separation of oligosaccharides ', Analytica Chimica Acta, 662, (2) pp. 206-213. ISSN 0003-2670 (2010) [Refereed Article]

DOI: 10.1016/j.aca.2010.01.011 [eCite] [Details]

Citations: Scopus - 10Web of Science - 8

Co-authors: Kazarian AA; Hilder EF; Breadmore MC; Quirino JP; Suttil J

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2010Molesworth PP, Gardiner MG, Jones R, Smith J, Tegg RS, et al., 'Synthesis and phytotoxicity of structural analogues of thaxtomin natural products', Australian Journal of Chemistry, 63, (5) pp. 813-820. ISSN 0004-9425 (2010) [Refereed Article]

DOI: 10.1071/CH10006 [eCite] [Details]

Citations: Scopus - 7Web of Science - 9

Co-authors: Molesworth PP; Gardiner MG; Jones R; Tegg RS; Wilson CR

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2010Tivendale ND, Davies NW, Molesworth PP, Davidson SE, Smith JA, et al., 'Reassessing the role of N-Hydroxytryptamine in auxin biosynthesis', Plant Physiology, 154, (4) pp. 1957-1965. ISSN 0032-0889 (2010) [Refereed Article]

DOI: 10.1104/pp.110.165803 [eCite] [Details]

Citations: Scopus - 34Web of Science - 30

Co-authors: Tivendale ND; Davies NW; Molesworth PP; Davidson SE; Lowe EK; Reid JB; Ross JJ

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2009Amos RIJ, Schiesser CH, Smith Jason, Yates BF, 'Nucleophilic Acyl Substitution of Acyl Diimides', Journal of Organic Chemistry, 74, (15) pp. 5707-5710. ISSN 0022-3263 (2009) [Refereed Article]

DOI: 10.1021/jo900923m [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Amos RIJ; Yates BF

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2009Amos RIJ, Smith Jason, Yates BF, Schiesser CH, 'Acyl radical addition to pyridine: multiorbital interactions', Tetrahedron, 65, (36) pp. 7653-7657. ISSN 0040-4020 (2009) [Refereed Article]

DOI: 10.1016/j.tet.2009.06.102 [eCite] [Details]

Citations: Scopus - 6Web of Science - 5

Co-authors: Amos RIJ; Yates BF

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2009Jones RC, Canty AJ, Deverell JA, Gardiner MG, Guijt RM, et al., 'Supported Palladium Catalysis Using a Heteroleptic 2-Methylthiomethylpyridine -N,S- Donor Motif for Mizoroki-Heck and Suzuki-Miyaura Coupling, Including Continuous Organic Monolith in Capillary Microscale Flow-Through Mode', Tetrahedron, 65, (36) pp. 7474-7481. ISSN 0040-4020 (2009) [Refereed Article]

DOI: 10.1016/j.tet.2009.07.013 [eCite] [Details]

Citations: Scopus - 30Web of Science - 32

Co-authors: Jones RC; Canty AJ; Deverell JA; Gardiner MG; Guijt RM; Rodemann T; Tolhurst V

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2009Quittenden LJ, Davies NW, Smith Jason, Molesworth PP, Tivendale N, et al., 'Auxin Biosynthesis in Pea: Characterization of the Tryptamine Pathway', Plant Physiology, 151, (3) pp. 1130-1138. ISSN 0032-0889 (2009) [Refereed Article]

DOI: 10.1104/pp.109.141507 [eCite] [Details]

Citations: Scopus - 43Web of Science - 43

Co-authors: Quittenden LJ; Davies NW; Molesworth PP; Tivendale N; Ross JJ

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2009Walker PW, Allen GR, Davies NW, Smith Jason, Molesworth PP, et al., 'Identification, Synthesis and Field Testing of (3Z,6Z,9Z)-3,6,9-Henicosatriene, a Second Bioactive Component of the Sex Pheromone of the Autumn Gum Moth, Mnesampela privata', Journal of Chemical Ecology, 35, (12) pp. 1411-1422. ISSN 0098-0331 (2009) [Refereed Article]

DOI: 10.1007/s10886-009-9717-2 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Walker PW; Allen GR; Davies NW; Molesworth PP

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2009Goemann A, Deverell JA, Munting KF, Jones Roderick, Rodemann T, et al., 'Palladium-mediated organic synthesis using porous polymer monolith formed in situ as a continuous catalyst support structure for application in microfluidic devices', Tetrahedron, 65, (7) pp. 1450-1454. ISSN 0040-4020 (2009) [Refereed Article]

DOI: 10.1016/j.tet.2008.12.007 [eCite] [Details]

Citations: Scopus - 55Web of Science - 54

Co-authors: Goemann A; Deverell JA; Munting KF; Jones Roderick; Rodemann T; Canty AJ; Guijt RM

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2008Amos RIJ, Gourlay BS, Schiesser CH, Smith Jason, Yates BF, 'A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid', Chemical Communications, 2008, (14) pp. 1695-1697. ISSN 1359-7345 (2008) [Refereed Article]

DOI: 10.1039/b719570b [eCite] [Details]

Citations: Scopus - 18Web of Science - 19

Co-authors: Amos RIJ; Gourlay BS; Yates BF

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2008Gourlay BS, Ryan JH, Smith Jason, 'Knorr-Rabe partial reduction of pyrroles: Application to the synthesis of indolizidine alkaloids', Beilstein Journal of Organic Chemistry, 4, (3) EJ ISSN 1860-5397 (2008) [Refereed Article]

DOI: 10.1186/1860-5397-4-3 [eCite] [Details]

Citations: Scopus - 1Web of Science - 7

Co-authors: Gourlay BS

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2008Canty AJ, Deverell JA, Goemann A, Guijt RM, Rodemann T, et al., 'Microfluidic devices for flow-through supported palladium catalysis on porous organic monolith', Australian Journal of Chemistry, 61, (8) pp. 630-633. ISSN 0004-9425 (2008) [Refereed Article]

DOI: 10.1071/CH08160 [eCite] [Details]

Citations: Scopus - 12Web of Science - 12

Co-authors: Canty AJ; Deverell JA; Goemann A; Guijt RM; Rodemann T

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2007Gardiner MG, Jones RC, Mason CM, Smith JA, Wise LE, '(RS)-2-(3,4-Methylenedioxyphenyl)-5-phenyl-3,6-dihydro-2H-pyran', Acta Crystallographica Section E, 63, (2) pp. O955-O957. ISSN 1600-5368 (2007) [Refereed Article]

DOI: 10.1107/S1600536807003194 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Gardiner MG; Jones RC; Mason CM; Wise LE

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2007Gardiner MG, Jones RC, Ng M, Smith JA, 'Methyl 4-chloro-3,5-di-p-tolyl-1H-pyrrole-2-carboxylate dichloromethane hemisolvate', Acta Crystallographica Section E, 63, (1) pp. O197-O199. ISSN 1600-5368 (2007) [Refereed Article]

DOI: 10.1107/S1600536806052202 [eCite] [Details]

Co-authors: Gardiner MG; Jones RC; Ng M

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2007Gardiner MG, Jones RC, Ng M, Smith JA, 'Methyl 4-p-tolyl-1H-pyrrole-2-carboxylate', Acta Crystallographica Section E, 63, (2) pp. O470-O471. ISSN 1600-5368 (2007) [Refereed Article]

DOI: 10.1107/S1600536806055103 [eCite] [Details]

Citations: Scopus - 12Web of Science - 12

Co-authors: Gardiner MG; Jones RC; Ng M

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2006Banwell MG, Goodwin TE, Ng M, Smith JA, Wong DJ, 'Palladium-Catalysed Cross-Coupling and Related Reactions Involving Pyrroles', European Journal of Organic Chemistry, 2006, (14) pp. 3043-3060. ISSN 1434-193X (2006) [Refereed Article]

DOI: 10.1002/ejoc.200500911 [eCite] [Details]

Citations: Scopus - 66Web of Science - 73

Co-authors: Ng M

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2006Bolton K, Canty AJ, Deverell JA, Guijt RM, Hilder EF, et al., 'Macroporous monolith supports for continuous flow capillary microreactors', Tetrahedron Letters, 47, (52) pp. 9321-9324. ISSN 0040-4039 (2006) [Refereed Article]

DOI: 10.1016/j.tetlet.2006.10.113 [eCite] [Details]

Citations: Scopus - 33Web of Science - 31

Co-authors: Bolton K; Canty AJ; Deverell JA; Guijt RM; Hilder EF; Rodemann T

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2006Gourlay BS, Little I, Ryan JH, Smith JA, 'A General and Efficient Approach to the Proposed Structures of Frog Toxins: The 5-Alkylindolizidines', Natural Product Communications, 1, (10) pp. 831-837. ISSN 1934-578X (2006) [Refereed Article]

[eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Gourlay BS; Little I

2006Gourlay BS, Molesworth PP, Ryan JH, Smith JA, 'A new and high yielding synthesis of unstable pyrroles via a modified Clauson-Kaas reaction', Tetrahedron Letters, 47, (5) pp. 799-801. ISSN 0040-4039 (2006) [Refereed Article]

DOI: 10.1016/j.tetlet.2005.11.104 [eCite] [Details]

Citations: Scopus - 23Web of Science - 23

Co-authors: Gourlay BS; Molesworth PP

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2006Hutchinson J, Hilder EF, Shellie RA, Smith JA, Haddad PR, 'Towards high capacity latex-coated porous polymer monoliths as ion-exchange stationary phases', Analyst, 131, (2) pp. 215-221. ISSN 0003-2654 (2006) [Refereed Article]

DOI: 10.1039/b511398a [eCite] [Details]

Citations: Scopus - 71Web of Science - 68

Co-authors: Hutchinson J; Hilder EF; Shellie RA; Haddad PR

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2006Smith JA, Ng M, White J, 'The regioselective synthesis of aryl pyrroles', Organic and Biomolecular Chemistry, 4, (12) pp. 2477-2482. ISSN 1477-0520 (2006) [Refereed Article]

DOI: 10.1039/b604692d [eCite] [Details]

Citations: Scopus - 28Web of Science - 29

Co-authors: Ng M

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2005Amos RIJ, Gourlay BS, Molesworth PP, Smith JA, Sprod OR, 'Annulation of pyrrole: application to the synthesis of indolizidine alkaloids', Tetrahedron, 61, (34) pp. 8226-8230. ISSN 0040-4020 (2005) [Refereed Article]

DOI: 10.1016/j.tet.2005.06.026 [eCite] [Details]

Citations: Scopus - 41Web of Science - 35

Co-authors: Amos RIJ; Gourlay BS; Molesworth PP; Sprod OR

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2003Banwell MG, Edwards AJ, Jolliffe KA, Smith JA, Hamel E, et al., 'Total synthesis of (±)-rhazinal, an alkaloid spindle toxin from Kopsia teoi', Organic and Biomolecular Chemistry, 1, (2) pp. 296-305. ISSN 1477-0520 (2003) [Refereed Article]

DOI: 10.1039/b209992f [eCite] [Details]

Citations: Scopus - 56Web of Science - 58

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2002Banwell MG, Coster MJ, Karunaratne OP, Smith JA, 'A chemoenzymatic synthesis of the styryllactone (+)-goniodiol', Royal Society of Chemistry, Perkin Transactions I, (14) pp. 1622-1624. ISSN 1470-4358 (2002) [Refereed Article]

DOI: 10.1039/b205230j [eCite] [Details]

Citations: Web of Science - 17

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2002Banwell MG, Smith JA, 'Exploiting multiple nucleophilic sites on pyrrole for the assembly of polyheterocyclic frameworks: application to a formal total synthesis of (+/-)-aspidospermidine', Journal of the Chemical Society, Perkins Transactions I, (23) pp. 2613-1618. ISSN 1470-4358 (2002) [Refereed Article]

DOI: 10.1039/b208821e [eCite] [Details]

Citations: Web of Science - 29

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2001Banwell MG, Smith JA, 'A mild one-pot method for the conversion of carboxylic acids into the corresponding weinreb amides', Synthetic Communications, 31, (13) pp. 2011-2019. ISSN 0039-7911 (2001) [Refereed Article]

DOI: 10.1081/SCC-100104418 [eCite] [Details]

Citations: Web of Science - 22

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2000Banwell MG, Edwards AJ, Smith JA, Hamel E, Verdier-Pinard P, 'Convergent synthesis and preliminary biological evaluation of (+/-)-B-norrhazinal', Journal of the Royal Society of Chemistry, Perkin Transactions I, (10) pp. 1497-1499. ISSN 1470-4358 (2000) [Refereed Article]

DOI: 10.1039/b001731k [eCite] [Details]

Citations: Web of Science - 17

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Chapter in Book

(7 outputs)
YearCitationAltmetrics
2015Ryan JH, Smith JA, Hyland C, Meyer AG, Williams CC, et al., 'Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier, GW Gribble, JA Joule (ed), Amsterdam, The Netherlands, pp. 531-573. ISBN 978-0-08-100024-3 (2015) [Research Book Chapter]

DOI: 10.1016/B978-0-08-100024-3.00016-7 [eCite] [Details]

Co-authors: Bissember AC; Just J

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2014Ryan JH, Smith JA, Hyland C, Meyer AG, Williams CC, et al., 'Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier, GW Gribble, JA Joule (ed), Amsterdam, The Netherlands, pp. 521-571. ISBN 978-0-08-100017-5 (2014) [Research Book Chapter]

DOI: 10.1016/B978-0-08-100017-5.00016-9 [eCite] [Details]

Co-authors: Bissember AC; Just J

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2013Ryan JH, Hyland C, Just J, Meyer AG, Smith JA, et al., 'Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier, GW Gribble, JA Joule (ed), Oxford, United Kingdom, pp. 455-497. ISBN 978-0-08-099406-2 (2013) [Research Book Chapter]

DOI: 10.1016/B978-0-08-099406-2.00017-0 [eCite] [Details]

Citations: Scopus - 3

Co-authors: Just J

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2012Ryan JH, Hyland C, Meyer AG, Smith JA, Yin J, 'Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier, GW Gribble, JA Joule (ed), Oxford, United Kingdom, pp. 493-536. ISBN 978-0-08-096807-0 (2012) [Research Book Chapter]

DOI: 10.1016/B978-0-08-096807-0.00016-6 [eCite] [Details]

Citations: Scopus - 5

Co-authors: Hyland C

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2011Smith JA, Molesworth PP, Hyland CJT, Ryan JH, 'Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier, GW Gribble, JA Joule (ed), Amsterdam, pp. 491-536. ISBN 978-0-08-096685-4 (2011) [Research Book Chapter]

[eCite] [Details]

Co-authors: Molesworth PP; Hyland CJT

2009Smith Jason, Molesworth PP, Ryan JH, 'Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier, G.W. Gribble and J.A. Joule (ed), Amsterdam, pp. 491-530. ISBN 978-0-08-096515-4 (2009) [Research Book Chapter]

DOI: 10.1016/S0959-6380(09)70044-3 [eCite] [Details]

Citations: Scopus - 8

Co-authors: Molesworth PP

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2009Smith Jason, Ryan JH, 'Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier, G.W. Gribble and J.A. Joule (ed), Amsterdam, pp. 432-458. ISBN 978-0-08-046975-1 (2009) [Research Book Chapter]

DOI: 10.1016/S0959-6380(09)70021-2 [eCite] [Details]

Citations: Scopus - 3

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Conference Publication

(5 outputs)
YearCitationAltmetrics
2009Davies NW, Walker PW, Allen GR, Smith Jason, Molesworth PP, et al., 'The Autumn Gum Moth sex pheromone - an elusive blend of alkatrienes', Proceedings of the 22nd Conference of the Australian and New Zealand Society for Mass Spectrometry ( ANZSMS22), 27-30 January 2008, Sydney Conservatorium of Music, Sydney, Australia (2009) [Conference Extract]

[eCite] [Details]

Co-authors: Davies NW; Walker PW; Allen GR; Molesworth PP

2008Canty AJ, Deverell JA, Gardiner MG, Goemann A, Guijt RM, et al., 'Miniaturising Metal Catalysis at the Micrometre Level in Capillaries and Glass Chips', IC08: Royal Australian Chemical Institute Conference of the Inorganic Division Programme and Books of Abstracts, 14-18 December 2008, University of Canterbury, Christchurch New Zealand, pp. 49. (2008) [Conference Extract]

[eCite] [Details]

Co-authors: Canty AJ; Deverell JA; Gardiner MG; Goemann A; Guijt RM; Jones Roderick; Rodemann T; Tolhurst V

2008Canty AJ, Deverell JA, Gardiner MG, Goemann A, Guijt RM, et al., 'Miniaturising organic monolith supported metal catalysis at the sub-micrometre level in capillaries and glass chip', 4th EuCheMS Conference on Nitrogen Ligands in Coordination Chemistry, Metal-Organic Chemistry, Bioinorganic Chemistry and Homogeneous Catalysis Program and Book of Abstracts, 24-28 August 2008, Garmisch-Partenkirchen, Germany, pp. 64. (2008) [Conference Extract]

[eCite] [Details]

Co-authors: Canty AJ; Deverell JA; Gardiner MG; Goemann A; Guijt RM; Jones Roderick; Rodemann T; Tolhurst V

2007Bolton KF, Canty AJ, Deverell JA, Guijt RM, Hilder EF, et al., 'Capillary Microreactor Catalysis Utilising Solid Organic Macroporous Monolith Supports', IC07: Royal Australian Chemical Institute Conference of the Inorganic Division Program and Conference Papers, 4-8 Feb 2007, Wrest Point Convention Centre, Hobart, pp. Poster 204. (2007) [Conference Extract]

[eCite] [Details]

Co-authors: Bolton KF; Canty AJ; Deverell JA; Guijt RM; Hilder EF; Rodemann T; Goemann A

2007Quittenden LJ, Davies NW, Smith JasonAlfred, Symons GM, Ross JJ, 'A compound-based approach to unraveling auxin biosynthesis in pea', The International Plant Growth Substances Association 19th Conference, Book of Abstracts, July 21-25, 2007, Puerto Vallarta, Mexico . (2007) [Conference Extract]

[eCite] [Details]

Co-authors: Quittenden LJ; Davies NW; Symons GM; Ross JJ

Grants & Funding

Funding Summary

Number of grants

19

Total funding

$1,029,983

Projects

Synthesis of Opiate Derivatives (2015)$20,000
Funding
Tasmanian Alkaloids Pty Ltd ($20,000)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Smith JA; Bissember AC
Year
2015
Chemika impurity characterisation - ICH guidelines (2014)$8,794
Description
This project will identify degradation products that arise during routine quality control assays as part of compliance with ICH guidelines. Degradation products will be identified using a three step process of UPLC with low resolution MS and fractionation and purity testing, followed by high resolution MS (orbitrap), with subsequent NMR.
Funding
Chemika Pty ltd ($8,794)
Scheme
Consultancy
Administered By
University of Tasmania
Research Team
Jacobson GA; Davies NW; Wilson RK; Horne HJ; Smith JA
Year
2014
Scientific opinion on Patent (2014)$17,826
Funding
Griffith Hack ($17,826)
Scheme
Consultancy
Administered By
University of Tasmania
Research Team
Smith JA
Year
2014
The role of plant hormones in legume symbioses (2014 - 2016)$436,000
Description
Soil microbes can give plants access to previously unavailable but essential nutrients through symbioses. Legumes are unique as they form symbioses with both nitrogen-fixing bacteria and with mycorrhizal fungi that supply nutrients such as phosphate. This project will investigate the role of the plant hormones (small, mobile, potent growth regulators) in the formation of these symbiotic relationships across legume genera. An insight into the common and divergent roles of hormones in these symbioses is essential to provide researchers and breeders with new tools to maximise nutrient acquisition by legumes, important crops contributing an estimated A$1 billion/y to the Australian economy.
Funding
Australian Research Council ($436,000)
Scheme
Grant-Discovery Projects
Administered By
University of Tasmania
Research Team
Reid JB; Foo E; Davies NW; Smith JA
Period
2014 - 2016
Grant Reference
DP140101709
Neuroprotective function of novel short chain-quinones (2013)$9,090
Description
Most eye disorders are associated with mitochondrial dysfunction. Based on the mitochondria-protective drug idebenone, we will synthesize novel, improved neuroprotective compounds. These compounds will be tested in a microfluidics cell culture model of mechanical stress-induced neuro-degeneration to identify new treatments strategies against retinal degeneration.
Funding
Royal Hobart Hospital Research Foundation ($9,090)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
McCartney PJ; Guven N; Guijt RM; Smith JA
Year
2013
Beetle aggregation research (2012)$2,000
Funding
Hydro Tasmania ($2,000)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Allen GR; Quarrell SR; Davies NW; Smith JA
Year
2012
2012: International Conference on Organic Synthesis (ICOS 19), (2012)$700
Funding
University of Tasmania ($700)
Scheme
Grant-Conference Support Scheme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2012
Scientific Opinion on Patent (2011)$19,091
Funding
Houlihan2 ($19,091)
Scheme
Consultancy
Administered By
University of Tasmania
Research Team
Smith JA
Year
2011
June 2011: International Society of Heterocyclic Chemistry (2011)$2,497
Funding
University of Tasmania ($2,497)
Scheme
Grant-Conference Support Scheme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2011
New Methods for the Template Mediated Synthesis of Biologically Active Compounds (2009)$14,250
Funding
University of Tasmania ($14,250)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2009
Chemical Reactivity of Opiates and Synthesis of New Opiate Derivatives (2008 - 2010)$348,831
Funding
Tasmanian Alkaloids Pty Ltd ($348,831)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Smith JA
Period
2008 - 2010
Development of novel, host-directed antimalarial compounds (2008)$75,000
Funding
University of Tasmania ($75,000)
Scheme
Grant-Pre Seed
Administered By
University of Tasmania
Research Team
Foote SJ; Smith JA; McMorran BJ
Year
2008
Investigation into Synthetic Methods for the Synthesis of Biologically Active Molecules: Pyrrolidine and Proline Derivates (2007)$7,950
Funding
University of Tasmania ($7,950)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2007
The Development of New Antibiotics Targeted Towards Multi Drug Resistant Tuberculosis (2006)$12,000
Funding
University of Tasmania ($12,000)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2006
Microreactors for Organic Synthesis (2005)$15,000
Funding
University of Tasmania ($15,000)
Scheme
Grant-RCB Research Support Scheme
Administered By
University of Tasmania
Research Team
Rodemann T; Guijt RM; Smith JA
Year
2005
Synthesis of Standards for the Monitoring of Bioremediation of Hydrocarbon Fuels (2005)$1,000
Funding
Department of Environment (Cwth) ($1,000)
Scheme
Grant-Human Impacts Research Programme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2005
Investigating the Chemical Properties of Alkaloid components (2004)$7,500
Funding
Tasmanian Alkaloids Pty Ltd ($7,500)
Scheme
Consultancy
Administered By
University of Tasmania
Research Team
Smith JA
Year
2004
New Synthetic Technology for the Synthesis of Biologically Important Compounds (2004)$22,000
Funding
University of Tasmania ($22,000)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2004
Biomimetic Approach to the Synthesis of Alkaloids: Dinuclear Manganese Complexes as Mimics of Cytochrome P450 in Oxidative Phenolic Coupling (2002)$10,454
Funding
University of Tasmania ($10,454)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2002

Research Supervision

Current

10

Completed

7

Current

DegreeTitleCommenced
PhDAn Evaluation and Redevelopment of Current Laboratory Practices: An in-depth study into the differences between learning and teaching styles2013
PhDSynthesis of New Derivatives Targeting Mitochondrial Disease2013
PhDOxidation of Pyrroles: Applications to the Sythesis of Biologically Active Molecules2014
PhDChemical survey of Tasmanian land plants by Hot Pressurised Water Extraction (HPWE) targeting new molecular scaffolds for chemical modification for medicinal chemistry applications2014
PhDSecondary Metabolites from Tasmanian Plants2014
PhDSynthesis of Plant Hormones2015
PhDThe Extraction of Native Australian and Endemic Tasmanian Plants using a Pressurised Hot Water Extraction (PHWE) method: Screening for chemical scaffolds for synthesis and wider applications2015
PhDNew Methods for the Construction of Medium-Sized Heterocycles and their Applications to Complex Molecule Synthesis2015
PhDSynthesis of WEB2086 Derivatives for the Treatment of Inflammatory Diseases resulting from Respiratory Pathogens2016
PhDHalogen Bonding for the Self Assembly of Helicates2016

Completed

DegreeTitleCompleted
PhDNew Methods for the Synthesis of Nitrogen Containing, Biologically Relevant Small Molecules
Candidate: James Kenneth Howard
2015
MastersOxazolopyridines towards the Treatment of Human African Sleeping Sickness
Candidate: Basmah Mohammed K Almohaywi
2014
PhDThe Biosynthesis of Two Naturally-occurring Auxins in Pisum sativum L
Candidate: Nathan David Tivendale
2012
PhDA Study of the Physical Chemistry of Acyl Radicals - Formation and Reactions
Candidate: Ruth Irene Joan Amos
2010
PhDNew Synthetic Approaches to Indolizidine and Pyrrolidine Alkaloids
Candidate: Brendon Scott Gourlay
2010
PhDStudies on the Synthesis of Biologically Active, Small Molecule Natural Products
Candidate: Peter Patrick Molesworth
2010
PhDRegioselective Modification of Pyrroles - Applications Towards Lamellarins & Pyrrolidine Analogues
Candidate: Sarah Man Yee Ng
2010