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Dale Kunde

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Dale Kunde

Lecturer in Clinical Chemistry

Room C212, Building C, NH BA25, Newnham Campus

+61 3 6324 5496 (phone)

+61 3 6324 3995 (fax)

Dale.Kunde@utas.edu.au

Dr Dale Kunde is a Lecturer in Clinical Chemistry in the School of Health Sciences within the Faculty of Health. He is interested in the mucosal immunology and especially the interaction of the gut microbiome and host pathophysiology.

Career summary

Qualifications

Degree Thesis title University CountryAwarded
PhD 'Molecular Biological aspects of Vanilloid and Related Receptors' University of Tasmania Australia 2010
BAppSci (1st Class Hons) 'An Improved Screening Test for 5-HIAA' University of Tasmania Australia 1997
BSc
Griffith University Australia 1984

Biography

Dale obtained his BSc in Biochemistry at Griffith University, Qld before working as a Hospital Scientist at the Royal Hobart Hospital in Clinical Biochemistry for a number of years. He took up a position at the University of Tasmania teaching Clinical Biochemistry in the Biomedical Science degree. He has since obtained a First Class Honours and PhD in the School of Health Sciences.

Research Themes

Dale's research aligns with the University's research theme of Better Health and the Faculty of Health's subtheme of Biomedicine. His doctoral studies investigated the molecular aspects of vanilloid and related receptor expression and function and led to identification of novel roles of TRPV1 in inflammatory responses. His research interests also include understanding the complex interaction of factors that result in intestinal inflammation conditions such as Ulcerative Colitis and Crohns's Disease especially the capacity of dietary polyphenols and a healthy gut 'microbiome' to reduce Endoplasmic Reticulum (ER) stress that results in pathological inflammation. Another area of research interest is in microbial genetics, particularly the genes involved in conferring antimicrobial resistance and pathogenicity in non-typeable Haemophilus Influenzae.

Memberships

Professional practice

  • Australasian Association of Clinical Biochemists
  • Australian Institute of Medical Scientists

Administrative expertise

Dale is co-ordinator of the Molecular Biology Research Facility in the School of Health Sciences.

Teaching

Clinical Biochemistry, Laboratory Medicine, Molecular Biology, Human Genetics

Teaching expertise

Dale co-ordinates and teaches the Clinical Biochemistry professional stream of the Bachelor of Biomedical Science. He designed and co-ordinated the Human Molecular Biology introducing modern genetic testing and molecular diagnostics to the Biomedical Science degree.

Teaching responsibility

View more on Dr Dale Kunde in WARP

Expertise

Dale has extensive Molecular Biology experience particularly expression analysis through traditional techniques and modern high throughput sequencing methodologies such as RNA-Seq utilising advanced bioinformatic data analysis.

Collaboration

Dale has a close research partnership with the Department of Immunopathology, IRCCS, Castellana Grotte, Italy investigating molecular mechanisms of inflammation in ulcerative colitis and immunopathology of intestinal inflammation.

Current projects

  • Expression and function of TRPV1 on human monocytes
  • Efficacy of Bitter Melon extract in ameliorating ER stress
  • Identification of genes involved in cellular invasion of NTHi

Research Fields

  • Basic Pharmacology (111501)
  • Nephrology and Urology (110312)
  • Medical Bacteriology (110801)
  • Medical Biochemistry: Nucleic Acids (110105)
  • Infectious Diseases (110309)
  • Haematology (110202)
  • Analytical Chemistry (030199)
  • Immunology (110799)
  • Nutrition and Dietetics (111199)
  • Cell Development, Proliferation and Death (060103)
  • Central Nervous System (110903)
  • Clinical Chemistry (diagnostics) (110302)
  • Respiratory Diseases (110203)
  • Animal Physiology - Systems (060603)
  • Cellular Immunology (110704)
  • Innate Immunity (110707)
  • Specialist Studies in Education (130399)
  • Medical Biochemistry: Lipids (110104)
  • Agricultural Biotechnology Diagnostics (incl. Biosensors) (100101)
  • Clinical Pharmacology and Therapeutics (111502)
  • Phycology (incl. Marine Grasses) (060701)
  • Veterinary Microbiology (excl. Virology) (070707)
  • Pharmacology and Pharmaceutical Sciences (111599)
  • Clinical Microbiology (110303)
  • Preventive Medicine (111716)
  • Genetic Immunology (060406)
  • Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) (110106)
  • Community Child Health (111704)
  • Geriatrics and Gerontology (110308)
  • Optometry and Ophthalmology (111399)
  • Cancer Cell Biology (111201)
  • Toxicology (incl. Clinical Toxicology) (111506)
  • Health and Community Services (111708)
  • Allergy (110701)
  • Epigenetics (incl. Genome Methylation and Epigenomics) (060404)
  • Cell Neurochemistry (060105)
  • Tumour Immunology (110709)
  • Gastroenterology and Hepatology (110307)

Research Impact

  • Urogenital System and Disorders (920119)
  • Blood Disorders (920101)
  • Infectious Diseases (920109)
  • Immune System and Allergy (920108)
  • Diagnostic Methods (920203)
  • Respiratory System and Diseases (incl. Asthma) (920115)
  • Digestive System Disorders (920105)
  • Cardiovascular System and Diseases (920103)
  • Nutrition (920411)
  • Nervous System and Disorders (920111)
  • Inherited Diseases (incl. Gene Therapy) (920110)
  • Health (929999)
  • Expanding Knowledge in the Environmental Sciences (970105)
  • Fisheries - Aquaculture (830199)
  • Education and Training Systems (930599)
  • Sheep - Meat (830310)
  • Disease Distribution and Transmission (incl. Surveillance and Response) (920404)
  • Beef Cattle (830301)
  • Sheep - Wool (830311)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Clinical Health (Organs, Diseases and Abnormal Conditions) (920199)
  • Health Related to Ageing (920502)
  • Social Structure and Health (920413)

Publications

Total publications

47

Highlighted publications

(2 outputs)
YearTypeCitationAltmetrics
2013Journal ArticleKunde DA, Crawford A, Geraghty DP, 'Tachykinin (NK1, NK2 and NK3) receptor, transient receptor potential vanilloid 1 (TRPV1) and early transcription factor, cFOS, mRNA expression in rat tissues following systemic capsaicin treatment', Regulatory Peptides, 183 pp. 35-41. ISSN 0167-0115 (2013) [Refereed Article]

DOI: 10.1016/j.regpep.2013.03.001 [eCite] [Details]

Citations: Scopus - 2

Co-authors: Crawford A; Geraghty DP

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2007Journal ArticleSaunders CIM, Kunde DA, Crawford A, Geraghty DP, 'Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood', Molecular Immunology, 44, (6) pp. 1429-35. ISSN 0161-5890 (2007) [Refereed Article]

DOI: 10.1016/j.molimm.2006.04.027 [eCite] [Details]

Citations: Scopus - 62Web of Science - 58

Co-authors: Saunders CIM; Crawford A; Geraghty DP

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Journal Article

(18 outputs)
YearCitationAltmetrics
2016Omari SOM, Adams MJ, Kunde DA, Geraghty DP, 'Capsaicin-Induced Death of Human Haematological Malignant Cell Lines is Independent of TRPV1 Activation', Pharmacology ISSN 0031-7012 (2016) [Refereed Article]

[eCite] [Details]

Co-authors: Adams MJ; Geraghty DP

2016Singh NK, Kunde DA, Tristram SG, 'Effect of epithelial cell type on in vitro invasion of nontypeable Haemophilus influenzae', Journal of microbiological methods, 129 pp. 66-9. ISSN 0167-7012 (2016) [Refereed Article]

DOI: 10.1016/j.mimet.2016.07.021 [eCite] [Details]

Co-authors: Singh NK; Tristram SG

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2015Atkinson CT, Kunde DA, Tristram SG, 'Acquired macrolide resistance genes in Haemophilus influenzae?', Journal of Antimicrobial Chemotherapy, 70, (8) pp. 2234-2236. ISSN 0305-7453 (2015) [Refereed Article]

DOI: 10.1093/jac/dkv093 [eCite] [Details]

Citations: Scopus - 1Web of Science - 3

Co-authors: Tristram SG

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2015Delvecchio FR, Vadrucci E, Cavalcanti E, De Santis S, Kunde D, et al., 'Polyphenol administration impairs T-cell proliferation by imprinting a distinct dendritic cell maturational profile', European Journal of Immunology, 45, (9) pp. 2638-2649. ISSN 0014-2980 (2015) [Refereed Article]

DOI: 10.1002/eji.201545679 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2014Alkadhi S, Kunde D, Cheluvappa R, Randall-Demllo S, Eri R, 'The murine appendiceal microbiome is altered in spontaneous colitis and its pathological progression', Gut pathogens, 6 Article 25. ISSN 1757-4749 (2014) [Refereed Article]

DOI: 10.1186/1757-4749-6-25 [eCite] [Details]

Citations: Scopus - 3Web of Science - 2

Co-authors: Randall-Demllo S; Eri R

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2014Atkins NA, Kunde DA, Zosky G, Tristram SG, 'Genotypically defined β-lactamase-negative ampicillin-resistant isolates of non-typable Haemophilus influenzae are associated with increased invasion of bronchial epithelial cells in vitro', Journal of Medical Microbiology, 63, (Pt 10) pp. 1400-3. ISSN 0022-2615 (2014) [Refereed Article]

DOI: 10.1099/jmm.0.077966-0 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Atkins NA; Zosky G; Tristram SG

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2014Zhang B, Kunde D, Tristram S, 'Haemophilus haemolyticus is infrequently misidentified as Haemophilus influenzae in diagnostic specimens in Australia', Diagnostic Microbiology and Infectious Disease, 80, (4) pp. 272-273. ISSN 0732-8893 (2014) [Refereed Article]

DOI: 10.1016/j.diagmicrobio.2014.08.016 [eCite] [Details]

Citations: Scopus - 1Web of Science - 2

Co-authors: Zhang B; Tristram S

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2013Kunde DA, Crawford A, Geraghty DP, 'Tachykinin (NK1, NK2 and NK3) receptor, transient receptor potential vanilloid 1 (TRPV1) and early transcription factor, cFOS, mRNA expression in rat tissues following systemic capsaicin treatment', Regulatory Peptides, 183 pp. 35-41. ISSN 0167-0115 (2013) [Refereed Article]

DOI: 10.1016/j.regpep.2013.03.001 [eCite] [Details]

Citations: Scopus - 2

Co-authors: Crawford A; Geraghty DP

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2013Witherden EA, Kunde D, Tristram SG, 'PCR screening for the N526K substitution in isolates of Haemophilus influenzae and Haemophilus haemolyticus', Journal of Antimicrobial Chemotherapy, 68, (10) pp. 2255-2258. ISSN 0305-7453 (2013) [Refereed Article]

DOI: 10.1093/jac/dkt189 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Witherden EA; Tristram SG

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2012Crawford A, Fassett RG, Coombes JS, Kunde DA, Ahuja KDK, et al., 'Relationship between antioxidant enzyme genotype and activity and kidney function: a case-control study', Clinical Nephrology, 78, (2) pp. 135-144. ISSN 0301-0430 (2012) [Refereed Article]

DOI: 10.5414/CN107421 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Crawford A; Ahuja KDK; Robertson IK; Ball MJ; Geraghty DP

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2012Crawford Amanda, Fassett RG, Geraghty DP, Kunde DA, Ball MJ, et al., 'Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease', Gene, 501, (2) pp. 89-103. ISSN 0378-1119 (2012) [Refereed Article]

DOI: 10.1016/j.gene.2012.04.011 [eCite] [Details]

Citations: Scopus - 61Web of Science - 56

Co-authors: Crawford Amanda; Geraghty DP; Ball MJ; Robertson IK

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2012Witherden EA, Kunde D, Tristram SG, 'An evaluation of SNP-based PCR methods for the detection of a-lactamase-negative ampicillin-resistant Haemophilus influenzae', Journal of Infection and Chemotherapy, 18, (4) pp. 451-455. ISSN 1341-321X (2012) [Refereed Article]

DOI: 10.1007/s10156-011-0356-5 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Witherden EA; Tristram SG

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2011Crawford A, Fassett RG, Coombes JS, Kunde DA, Ahuja KDK, et al., 'Glutathione peroxidase, superoxide dismutase and catalase genotypes and activities and the progression of chronic kidney disease', Nephrology Dialysis Transplantation, 26, (9) pp. 2806-2813. ISSN 1460-2385 (2011) [Refereed Article]

DOI: 10.1093/ndt/gfq828 [eCite] [Details]

Citations: Scopus - 21Web of Science - 16

Co-authors: Crawford A; Ahuja KDK; Robertson IK; Ball MJ; Geraghty DP

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2011Geraghty DP, Mazzone SB, Carter C, Kunde DA, 'Effects of Systemic Capsaicin Treatment on TRPV1 and Tachykinin NK1 Receptor Distribution and Function in the Nucleus of the Solitary Tract of the Adult Rat', Pharmacology, 87, (3-4) pp. 214-223. ISSN 0031-7012 (2011) [Refereed Article]

DOI: 10.1159/000324530 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Geraghty DP; Carter C

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2011Heng YJ, Saunders CIM, Kunde DA, Geraghty DP, 'TRPV1, NK1 receptor and substance P immunoreactivity and gene expression in the rat lumbosacral spinal cord and urinary bladder after systemic, low dose vanilloid administration', Regulatory Peptides, 167, (2-3) pp. 250-258. ISSN 0167-0115 (2011) [Refereed Article]

DOI: 10.1016/j.regpep.2011.02.004 [eCite] [Details]

Citations: Scopus - 7Web of Science - 6

Co-authors: Heng YJ; Saunders CIM; Geraghty DP

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2007Saunders CIM, Kunde DA, Crawford A, Geraghty DP, 'Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood', Molecular Immunology, 44, (6) pp. 1429-35. ISSN 0161-5890 (2007) [Refereed Article]

DOI: 10.1016/j.molimm.2006.04.027 [eCite] [Details]

Citations: Scopus - 62Web of Science - 58

Co-authors: Saunders CIM; Crawford A; Geraghty DP

Tweet

2006Ahuja KDK, Kunde DA, Ball MJ, Geraghty DP, 'Effects of capsaicin, dihydrocapsaicin and curcumin on copper-induced oxidation of human serum lipids', Journal of Agricultural and Food Chemistry, 54, (17) pp. 6436-6439. ISSN 0021-8561 (2006) [Refereed Article]

DOI: 10.1021/jf061331j [eCite] [Details]

Citations: Scopus - 28Web of Science - 24

Co-authors: Ahuja KDK; Ball MJ; Geraghty DP

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1995Kunde DA, 'Book review - HPLC of Proteins, Peptides and Polynucleotides: Contemporary Topics and Applications by MTW Hearn', Australian Journal of Medical Science, 16, (4) pp. 191-192. ISSN 1038-1643 (1995) [Letter or Note in Journal]

[eCite] [Details]

Review

(1 outputs)
YearCitationAltmetrics
2013Basheer W, Kunde DA, Eri RD, 'Role of Chemokine Ligand CCL20 and its Receptor CCR6 in lntestinal Inflammation', Immunology and Infectious Diseases, 1, (2) pp. 30-37. ISSN 2333-2719 (2013) [Substantial Review]

DOI: 10.13189/iid.2013.010203 [eCite] [Details]

Co-authors: Basheer W; Eri RD

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Conference Publication

(28 outputs)
YearCitationAltmetrics
2015Kunde DA, Almalki Y, Geraghty DP, 'Differential expression of TRPV1 on circulating PBMC sub-populations assessed by confocal microscopy', APSA-ASCEPT Joint Scientific Meeting 2015, 29 November - 2 December, 2015, Hobart, Tasmania (2015) [Conference Extract]

[eCite] [Details]

Co-authors: Geraghty DP

2014Untari L, Burke C, Kunde D, Murray S, Bolch C, 'Quantitative detection of G. catenatum by qPCR based on the rDNA-ITS and sxtA4 genes', The 16th International Conference on Harmful Algae Book of Abstracts, 27-31 October, Wellington, New Zealand, pp. 59. (2014) [Conference Extract]

[eCite] [Details]

Co-authors: Untari L; Burke C; Bolch C

2012Omari SAM, Geraghty DP, Kunde DA, Adams MJ, 'Inhibition of Human Haematological Malignant Cell Lines by Capsaicin is not TRPV1-Mediated', Annual Combined ASM of the HSANZ/ANZBT/ASTH and the APSTH, 28 - 31 October 2012, Melbourne, Australia (2012) [Conference Extract]

[eCite] [Details]

Co-authors: Omari SAM; Geraghty DP; Adams MJ

2012Kunde DA, 'Undergraduate clinical biochemistry: contextualising scientific compentencies for the modern laboratory', Proceedings of the 50th AACB Scientific Conference 2012, 15 -18 November 2012, Melbourne, Australia, pp. 87. (2012) [Conference Extract]

[eCite] [Details]

2011Geraghty DP, Adams MJ, Saunders CI, Kunde DA, Fassett RG, et al., 'Leukocyte TRPV1 Expression and Function in Health and Disease', Proceeding of, July 29-30, Hobart, pp. 1. (2011) [Conference Extract]

[eCite] [Details]

Co-authors: Geraghty DP; Adams MJ

2010Kunde DA, Yingchoncharoen J, Jurkovic S, Geraghty DP, 'Transient receptor potential vanilloid 1 (TRPV1) in naive and THP-1 monocytes: role in cytokine release', Proceedings of ASCEPT, Dec 2010, Melbourne, pp. 111. (2010) [Conference Extract]

[eCite] [Details]

Co-authors: Jurkovic S; Geraghty DP

2009Crawford A, Kunde DA, Ahuja KDK, Robertson IK, Coombes JS, et al., 'Glutathione Peroxidase and Superoxide Dismutase: Genotype and Enzyme Activity in Progression of Chronic Kidney Disease', Nephrology, 7-9 Sept 2009, Hobart, pp. A49-A50. (2009) [Conference Extract]

[eCite] [Details]

Co-authors: Crawford A; Ahuja KDK; Robertson IK; Ball MJ; Geraghty DP

2009Kunde DA, Yingchoncharoen J, Geraghty DP, 'Transient receptor potential vanilloid 1 (TRPV1) IN the THP-1 monocytic cell line', Proceedings of ASCEPT, November, 2009, Sydney). O79., Sydney, pp. O79. (2009) [Conference Extract]

[eCite] [Details]

Co-authors: Geraghty DP

2009Crawford A, Kunde DA, Robertson IK, Geraghty DP, Ball MJ, et al., 'Glutathione peroxidase and superoxide dismutase: genotype and enzyme activity in progression of chronic kidney disease', Proceedings of the World Congress of Nephrology, 22-26 May, 2009, Milan (2009) [Conference Extract]

[eCite] [Details]

Co-authors: Crawford A; Robertson IK; Geraghty DP; Ball MJ

2008Crawford A, Kunde DA, Robertson IK, Coombes JS, Ball MJ, et al., 'Glutathione Peroxidase and Superoxide Dismutase: Genotype and Enzyme Activity in Progression of Chronic Kidney Disease', Proceedings of AHMRC/ASCEPT , Nov 2008, Brisbane, pp. p681. (2008) [Conference Extract]

[eCite] [Details]

Co-authors: Crawford A; Robertson IK; Ball MJ; Geraghty DP

2008Kunde DA, Whitmore B, Saunders CIM, Geraghty DP, 'Transient receptor potential vanilloid 1 (TRPV1) and TRPV2 mRNA expression and immunoreactivity on monocytes ', Proceedings of AHMRC/ASCEPT , Nov 2008, Brisbane, pp. p681. (2008) [Conference Extract]

[eCite] [Details]

Co-authors: Saunders CIM; Geraghty DP

2008Saunders CIM, Kunde DA, Fassett RG, Geraghty DP, 'Mononuclear cell transient receptor potential vanilloid 1 (TRPV1) expression and susceptibility to N-arachidonoyl-dopamine (NADA)-induced cell death in end-stage kidney disease (ESKD) patients', Proceedings of AHMRC/ASCEPT , Nov 2008, Brisbane, pp. p229. (2008) [Conference Extract]

[eCite] [Details]

Co-authors: Saunders CIM; Geraghty DP

2007Crawford A, Kunde DA, Robertson IK, Coombes JS, Ball MJ, et al., 'Glutathione Peroxidase Genotype and Enzyme Activity in Chronic Kidney Disease', Proceedings of World Congress of Nephrology, May 2007, Rio de Janeiro (2007) [Conference Extract]

[eCite] [Details]

Co-authors: Crawford A; Robertson IK; Ball MJ; Fassett RG; Geraghty DP

2007Crawford A, Kunde DA, Robertson IK, Coombes JS, Ball MJ, et al., 'Glutathione Peroxidase Genotype and Enzyme Activity in Chronic Kidney Disease', Proceedings of ASM of the Australian and New Zealand Society of Nephrology , Sept 10-12 2007, Gold Coast (2007) [Conference Extract]

[eCite] [Details]

Co-authors: Crawford A; Robertson IK; Ball MJ; Fassett RG; Geraghty DP

2007Saunders CIM, Kunde DA, Fassett RG, Geraghty DP, 'Transient receptor potential vanilloid 1 (TRPV1) channel message and immunoreactivity in peripheral blood mononuclear cells of end-stage renal disease (ESRD) patients', Proceedings of ASCEPT-SEAWP 2007, 2-6 Dec, 2007, Adelaide, pp. 66. (2007) [Conference Extract]

[eCite] [Details]

Co-authors: Saunders CIM; Geraghty DP

2006Ahuja KDK, Kunde DA, Ball MJ, Geraghty DP, 'Effects of capsaicinoids and curcumin on copper-induced oxidation of human serum', Proceedings of the AIMS/AACB 2006, 23-27 October 2006, Sydney, pp. P53. (2006) [Conference Extract]

[eCite] [Details]

Co-authors: Ahuja KDK; Ball MJ; Geraghty DP

2006Heng YJJ, Saunders CIM, Kunde DA, Geraghty DP, 'Effect of systemic vanilloids on TRPV1, substance P and tachykinin (NK1) receptors in the rat lumbosacral spinal cord and urinary bladder ', Proceedinghs of the Australian Health and Medical Research Congress 2006, 26 Nov-1 Dec 2006, Melbourne, pp. O86. (2006) [Conference Extract]

[eCite] [Details]

Co-authors: Heng YJJ; Saunders CIM; Geraghty DP

2006Garvey M, Ahuja KDK, Kunde DA, Geraghty DP, 'Antioxidants - the hot topic: the effect on DNA oxidation of chilli supplementation and in vitro capsaicin treatment', Proceedings of AIMS/AACB 2006, 23-27 October 2006, Hobart, pp. P79. (2006) [Conference Extract]

[eCite] [Details]

Co-authors: Garvey M; Ahuja KDK; Geraghty DP

2005Garvey M, Ahuja KDK, Kunde DA, Ball MJ, Geraghty DP, 'Ex vivo and in vitro actions of chilli and capsaicin on DNA Oxidation', Australasian Pharmaceutical Science Ass, 4-7 December 2005, Melbourne, pp. 92. (2005) [Conference Extract]

[eCite] [Details]

Co-authors: Garvey M; Ahuja KDK; Ball MJ; Geraghty DP

2005Kunde DA, Crawford A, Geraghty DP, 'Tachykinin (NK1) (NK2) (NK3) and transient receptor potential vanilloid 1 (TRPV1) mRNA expression in rat tissues 24 hours after capsaicin administration', Proceedings of the Australasian Society of Clinical and Experimental Pharmacologist and Toxicologists, 4-7 December 2005, Melbourne, pp. 65. (2005) [Conference Extract]

[eCite] [Details]

Co-authors: Crawford A; Geraghty DP

2005Saunders CIM, Crawford A, Kunde DA, Geraghty DP, 'Transient receptor potential vanilloid (TPRV) 1 and 2 Channel message and immunoreactivity in human mononuclear cells', Proceedings of the Australasian Society of Clinical and Experimental Pharmacologist and Toxicologists, 4-7 December 2005, Melbourne, pp. 87. (2005) [Conference Extract]

[eCite] [Details]

Co-authors: Saunders CIM; Crawford A; Geraghty DP

2004Sing BJ, Kunde DA, Heathcote D, 'The prevelence of thrombophilic mutations in Tasmanian patients with venous thrombosis', Proceedings of the 10th Asian-Pacific Congress of Clinical Biochemistry (The Clinical Biochemist Reviews), 18-23 Sept 2004, Perth WA, pp. S49. ISSN 0159-8090 (2004) [Conference Extract]

[eCite] [Details]

Co-authors: Heathcote D

2003Ahuja KDK, Kunde DA, Ball MJ, 'Effects of olive oil and tomato lycopene combination on heart disease risk factors', Proceedings of the Nutrition Society of Australia, December 1-3, 2003, Hobart, Tasmania, pp. S21. (2003) [Conference Extract]

[eCite] [Details]

Co-authors: Ahuja KDK; Ball MJ

2003Kunde DA, 'Molecular Diagnostic Methods', RCPA AACB Chemical Pathology Course, Feb 10-14, 2003, Launceston, Tasmania (2003) [Conference Extract]

[eCite] [Details]

2003Kunde DA, 'Nittys', RCPA AACB Chemical Pathology Course, Feb 10-14, 2003, Launceston, Tasmania (2003) [Conference Extract]

[eCite] [Details]

2001Kunde DA, Geraghty DP, 'Tachykinin receptor (NK1, NK2, NK3) message in the rat brain stem: effect of systemic capsaicin administration', Proceedings of ASCEPT, 3-5 December, 2001, Dunedin, New Zealand, pp. 82. ISSN 1322-4530 (2001) [Conference Extract]

[eCite] [Details]

Co-authors: Geraghty DP

2000Heathcote D, Beamish MR, Kunde DA, 'Tasmanian haemochromatosis study', Proceedings of AIMS 2000, June 2000, Sydney, Australia, pp. 36. (2000) [Conference Extract]

[eCite] [Details]

Co-authors: Heathcote D

1998Kunde DA, Day BR, 'An improved screening test for increased urinary 5-hydroxyindole-3-acetic acid (5-HIAA) excretion', The Clinical Biochemist - Reviews, 29th August-2nd September, 1998, Brisbane, pp. 82. (1998) [Conference Extract]

[eCite] [Details]

Co-authors: Day BR

Grants & Funding

Funding Summary

Number of grants

10

Total funding

$213,492

Projects

Exploring the mechanisms responsible for the early transformation from chronic colitis to colorectal cancer (2016)$28,000
Description
This project will be the first study to model early changes in inflammation-associated colitis without the need for carcinogentreatment, which mirrors the clinical situation of human colitis. The project will study the histological and biochemical changes associated with the development of colorectal cancer in this mouse model that closely resembles the development seen in humans. The project will also investigate the mirobiome changes in the progression.
Funding
Cancer Council of Tasmania ($28,000)
Scheme
Grant-Cancer Research
Administered By
University of Tasmania
Research Team
Kunde DA; Eri RD; Holloway AF
Year
2016
Preliminary development of a probiotic to minimise respiratory infection with Haemophilus influenzae (2016)$17,636
Description
A naturally occurring bacteriocin will be engineered into Haemophilus haemolyticus. As in vitro cell culture model will then be used to evaluate the ability of the bacteriocin producing H. haemolyticus to inhibit colonisation and growth of H. influenzae.
Funding
Clifford Craig Medical Research Trust ($17,636)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG; Kunde DA; Chia Collin
Year
2016
The landscape of gene expression changes in the aqueous humor drainage pathway of glaucoma patients (2015)$36,300
Description
The aims of this project are to: 1) define the entirety of genes expressed within the trabecular meshwork samples of glaucoma patients and controls; 2) correlate glaucoma-specific trabecular meshwork gene expression signatures to clinical parameters.
Funding
Clifford Craig Medical Research Trust ($36,300)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Cook AL; Toh TY; Kunde DA; Hewitt Alex
Year
2015
Whole genome sequencing of non-typeable H. influenzae to unravel pathogenesis and persistence (2014)$19,000
Description
Non-typeable Haemophilus influenzae (NTHi) is a genetically diverse bacterial commensal of the upper respiratory tract that is also an important opportunistic pathogen when the host is compromised by various disease states. NTHi is a common cause of infectious exacerbations of chronic obstructive pulmonary disease (COPD), community acquired pneumonia, otitis media and sinusitis. It is difficult to estimate the annual burden of disease attributable to NTHi in Australia, however respiratory infections in general are the most common reason for the prescription of antibiotics and accounts for approximately 20 million visits to general practitioners. COPD alone accounts for approximately 10 000 deaths, 55 000 hospitalisations and $400 million in healthcare costs and otitis media is one of the most common reasons for childrens GP visits and is associated with temporary hearing impairment and learning deficits. An incomplete understanding of the pathogenesis of infection with NTHi, the absence of a vaccine, increasing antibiotic resistance and the ability to persist in the host despite treatment are all factors which compromise our ability to adequately deal with or reduce the burden of NTHi disease.
Funding
University of Tasmania ($19,000)
Scheme
Grant-Research Enhancement (REGS)
Administered By
University of Tasmania
Research Team
Kunde DA; Tristram SG
Year
2014
Macrolide resistance in patients with chronic respiratory infections (2014)$15,750
Description
This project will investigate the effect of acquired macrolide resistance genes on survival mechanisms in H. influenzae. It will: a) determine if these genes are expressed (are functional) in this organism; b) determine if these genes increase the fitness of the organism when exposed to sub-lethal concentrations of macrolides; c) determine if the presence of these genes increases the survival of the organism in the intracellular environment of respiratory epithelial cells during exposure to macrolides. It seeks to determine the level of macrolide resistance / prevalence of macrolide resistance genes in identified respiratory pathogens and the general respiratory microbial population in patients with chronic respiratory conditions in Northern Tasmania. The study investigates the longitudinal effect of macrolide therapy on the total respiratory microbial population of selected Northern Tasmanian chronic respiratory patients.
Funding
Clifford Craig Medical Research Trust ($15,750)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG; Kunde DA; Haug G; Atkinson C; Chuang M
Year
2014
Inhibition of platelet aggregation by vanilloid-like agents: a novel antithrombotic mechanism in patients with Systemic Lupus Erythematosus? (2013 - 2014)$27,273
Funding
Clifford Craig Medical Research Trust ($27,273)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Adams MJ; Geraghty DP; Kunde DA
Period
2013 - 2014
Biomarkers of chronic kidney disease and its progression in Northern Tasmanians (2013)$33,533
Funding
Clifford Craig Medical Research Trust ($33,533)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Geraghty DP; Fassett R; Coombes J; Robertson IK; Ball MJ; Kunde DA; Crawford A
Year
2013
Are altered penicillin binding proteins in H.influenzae associated with increased capacity to invade respiratory epithelial cells? (2013)$10,000
Funding
Clifford Craig Medical Research Trust ($10,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG; Kunde DA
Year
2013
Tachykinin Receptor Expression Localisation and Regulation by Vanilloid Administration (2004)$14,000
Funding
University of Tasmania ($14,000)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Geraghty DP; Kunde DA
Year
2004
Molecular Biological Studies of Tachykinin Receptor regulation by Vanilloids (2001)$12,000
Funding
University of Tasmania ($12,000)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Geraghty DP; Kunde DA
Year
2001

Research Supervision

Dale has supervised a number of Honours students over the years and currently supervises one MSc (research) and three PhD candidates.

Current

4

Completed

2

Current

DegreeTitleCommenced
PhDAnalysing the Regulatory and Effector T Cell Balance in Inflammatory Bowel Disease: Can the CCR6-CCL20 axis be exploited as a therapeutic Target2013
PhDAcquired Macrolide Resistance Genes in Non-typeable Haemophilus influenzae2013
MastersIdentification of genes involved in increased invasiveness of transformed non-invasive nontypeable Haemophilus influenzae (NTHi) strain with invasive strain DNA using whole genome sequencing2014
PhDThe Role of Inflammasomes in the Pathogenesis of Inflammatory Bowel Disease2015

Completed

DegreeTitleCompleted
PhDInfluence of Antioxidant Genotype and Antioxidant Status on Progression of Chronic Kidney Disease
Candidate: Amanda Crawford
2010
PhDSelenium, Zinc and Copper Status in Tasmania: Dietary, Lifestyle and Some Genetic Associations
Candidate: Jeffrey Maxwell Beckett
2010