Profiles

Raj Eri

UTAS Home Doctor Raj Eri

Raj Eri

Senior Lecturer

Room 221, C, Newnham Campus

+ 61 3 6324 5467 (phone)

+ 61 3 6324 5555 (fax)

Raj.Eri@utas.edu.au

Dr Eri was awarded a PhD in molecular biology by the University of Queensland in 2001 and continued to be a post-doc/senior scientist both in Australia and USA in the area of gut inflammation and immunology. In December 2010, he joined the University of Tasmania and established his independent group investigating topics in mucosal biology, establishing a national, and an emerging international, reputation in this area. Dr Eri also coordinates and teaches in the fields of immunology and biochemistry. Dr Eri's specific expertise includes simulation - to create virtual laboratories, technology enhanced learning, teaching-research nexus.

Dr Eri's research interests include the role of inflammasomes on bowel diseases and bowel cancer, early stage carcinogenesis pathways in colorectal cancer and the role of cytokines in inflammatory bowel disease (IBD) pathogenesis. His current research projects include inflammasomes in IBD, CCR6 in IBD pathogenesis, colorectal cancer pathways, heparin as anti-inflammatory agent in colitis, the role of bitter melon as anti-ER stress agent, and epidemiology of IBD in Tasmania.

Career summary

Qualifications

  • PhD, University of Queensland, Australia, 2001
  • M V Sc, TN Vetinary and Animal Sciences University, India, 1994
  • B V Sc, TN Vetinary and Animal Sciences University, India, 1990
  • Grad Cert T&L, University of Tasmania, 2012

Languages (other than English)

  • Hindi
  • Tamil
  • Esperanto
  • Telugu
  • Kannada

Biography

CIA Eri (DVM, PhD) is a veterinarian turned biomedical scientist with an emerging international reputation in the field of mucosal biology/immunology. His research interests include understanding the role of inflammasomes, chemokines (CCR6 and CCL20), IL-23/TH17 pathways in both murine and human IBD. Additionally, Dr Eri conducts research into the efficacy of natural products (bitter melon, raw banana, yogurt) in the treatment of IBD and a number pf pre-clinical studies are being carried in that direction.

His recent research interests include colorectal cancer and respiratory diseases such as asthma and COPD. Previously he was a senior research officer at the Mater Medical Research Institute (MMRI, now TRI, Brisbane). During this time he was chief investigator on 3 NHMRC and 1 Queensland Cancer Fund applications and was instrumental in providing ground breaking identification of ER stress in the pathogenesis of IBD. His PhD was awarded in 2001 from the University of Queensland and the initial post-doctoral work in mucosal immunology area was conducted in UCLA, USA. Since 2011, Dr Eri has established an independent laboratory at UTAS. Even as a 40:40:20 academic at UTAS, he has maintained a a very productive research career as evidenced from publications (20), grants (6) and graduate students (5) during that period. The collective impact of CIA Eri's contribution is highlighted by numerous worldwide collaborations with clinicians and researchers, invitations to speak at international meetings, invited reviews, as well as editorial and refereeing work. To cite a few examples, he was invited to edit an edition of Frontiers in Immunology, organised and  chaired  sessions at Gastroenterological Society of Australia (GESA) annual meetings, invited to speak at a number of conferences in Australia.  He published in prestigious journals (PLoS medicine, J Exp Med, Gut, BMJ). His work is widely cited (a total of ~ 1500 citations) with an average of more than 26 citations/paper and more than 350 citations for the highest cited paper.

Research Themes

Raj's research aligns to the University's research theme of Better Health. He has significant expertise in the fields of colitis and IBD that includes a multitude of animal models of colitis. Furthermore he was the first to describe the ER stress induced molecular pathology of a novel murine model of spontaneous colitis-Winnie. All the clinical, histological, immunological and immuno-histochemical methods have been optimised and being in current use in his research laboratory.

Overall, Raj has published over 25 papers and reviews in this specific field in high ranking journals in the areas of the role of ER stress, the pre-clinical efficacy of a number of food products/peptides/cytokines for the treatment of colitis.

Raj was specifically recruited to UTAS as a 'research active' academic. He has established a mucosal biology laboratory and already recruited many Honours/PhD students in his projects. He is trying to establish a niche for himself in the mucosal immunology area and is uniquely positioned as only one of a very few dedicated mucosal immunology researchers in Australia. His vision is to conduct high-quality research in the areas of chronic intestinal inflammation & colorectal cancer and contribute towards a better understanding of IBD pathogenesis and treatment. Furthermore, he would also like to conduct basic research in the area cell stress and apoptosis specifically in the intestinal epithelial cells. In addition to his science research, Raj has a keen interest in educational research as well. To this end, he currently holds a teaching development grant from UTAS.

Memberships

Professional practice

  • Australian Society for Medical Research (ASMR)- President-Tasmania: Three years of organizing Medical Research Week in Tasmania
  • NHMRC grants assessor: NHMRC has requested to review project grants for 2010-13. So far, assessed 6 grants
  • Manuscript Reviewer: 10 Journals including American Journal of Physiology (Gastro), Journal of Cellular Biochemistry, PLoS One etc.
  • MMRI student committee member: specially in-charge of recruitment: Organised MMRI student open days and also attended recruitment expos at UQ, QUT to attract students
  • MMRI seminar series coordinator: Arranged speakers every week for MMRI seminar series and coordinated the seminars- 2008
  • MMRI science week committee member: Part of national science week celebrations educating students and public from various parts of Queensland through public lectures – 2008-09
  • MMRI statistical task force member: Part of the committee that decides on statistical requirements for the institute
  • ASMR Queensland Premier's Award Committee member: Organising member for the prestigious awards for the last 4 years
  • Australasian Society for Immunology (ASI): Member for organising the national conference for 2009 at the Gold Coast
  • Organising Committee member for ASI-FIMSA: an advanced course in immunology 2009

Administrative expertise

  • Managed NHMRC research project as CIA
  • Graduate research coordination

Teaching

Teaching expertise

Raj has a strong commitment to strategies that bridge research and teaching by incorporating research principles into classroom teaching. He has introduced adaptive eLearning methods to augment student skills for better learning outcomes. His determination to motivate students to be independent learners has proven his excellence in teaching as evidenced by SETL/eVALUate/feedback from students and peers.

Raj has also been involved in a number of educational research projects (including investigator in 3 TDGs) & published 4 papers so far. He has an active commitment to the Tasmanian community.

Teaching responsibility

View more on Dr Raj Eri in WARP

Expertise

  • Chronic Inflammation
  • ER stress
  • Pathogenesis of inflammatory Bowel Disease
  • Gut Health
  • Pre-clinical models of gut health
  • Inflammasomes

Awards

  • Winner, rapid Research, UTAS, 2012
  • Finalist, Queensland Premier's Award for Medical Research, Senior category, 2010
  • UQ Reginald Ferguson fellowship in Gastroenterology Research, 2007
  • UQ Reginald Ferguson fellowship in Gastroenterology Research, 2006
  • Indiana University post-doctoral fellowship, USA, 2004
  • Queensland Protein Group best oral presentation award, 2000
  • Finalist, Young Investigator Award, Gastroenterology Week, Sydney, 2002
  • QIMR cancer unit PhD scholarship, 1999
  • Best Thesis Award - MVSc thesis - Veterinary Medicine, 1996

Collaboration

  • Prof Heinrich Korner - MRIT and University of Tasmania
  • Assoc Prof Nuri Guven - School of Pharmacy, University of Tasmania
  • Dr Rahul Patel - School of Pharmacy, University of Tasmania
  • Dr Lana Shabala - School of Agriculture, University of Tasmania
  • Dr Christine Booth - DSTO, Scottsdale
  • Dr Kulmira Nurgali - Victoria University, Melbourne
  • Drs Brent Mitchell, Scott Fanning, Ray Wilson - Launceston General Hospital
  • Dr Prathiba Nerurkar - University of Hawaii, U.S.A.
  • Dr Marcello Chieppa - Bari University, Italy
  • Prof Mike McGuckin - Mater Medical Research Institute/TRI, University of Queensland, Brisbane

Current projects

  1. The hierarchial activation of of inflammasomes in chronic colitis
    Inflammasomes are protein complexes that are implicated in initiation of many diseases including inflammatory bowel disease (IBD). In my laboratory, we have characterised a mouse model that develops spontaneous colitis similar to human colitis. We have a strong indication from human studies that specific inflammasomes are activated in IBD. In this mouse model, we want to explore functional studies as to how inflammasome contributes to pathogenesis of IBD.
  2. Characterisation of flat dysplasia in colitis associated colorectal cancer
    Patients with ulcerative colitis are at increased risk of developing colorectal cancer. Colitis-associated colorectal cancer (CACC) progresses through similar stepwise gene mutations observed in sporadic cancers, but the sequence in which they occur is reversed. Understanding the transition from colitis to tumour requires relevant animal models. Colonic carcinogenesis has been modelled using genotoxic carcinogens such as azoxymethane. We hypothesise that exacerbation of pre-existing chronic colitis in a Muc2 mutant (Winnie) mouse strain with dextran sulphate sodium (DSS) would induce colorectal tumorigenesis.
  3. CCR6 deficiency aggravates colitis in a spontaneous colitis model
    Chemokine receptor 6 (CCR6) and its ligand CCL20 is implicated to play a major role in IBD pathogenesis. The CCR6/CCL20 axis is involved in both immune regulation and activation. CCR6 is expressed by both pro-inflammatory cells and regulatory T cells elucidate the dual role of the receptor. The contradictory role of CCR6/CCL20 in inflammation/homeostasis requires further research.

Research Fields

  • Genetic Immunology (060406)
  • Animal Physiology - Systems (060603)
  • Cell Development, Proliferation and Death (060103)
  • Pharmaceutical Sciences (111504)
  • Gastroenterology and Hepatology (110307)
  • Immunology (110799)
  • Respiratory Diseases (110203)
  • Pharmacology and Pharmaceutical Sciences (111599)
  • Cell Neurochemistry (060105)
  • Optometry and Ophthalmology (111399)
  • Nutritional Physiology (111103)
  • Nutrition and Dietetics (111199)
  • Higher Education (130103)
  • Biochemistry and Cell Biology (060199)
  • Community Child Health (111704)
  • Animal Physiology - Cell (060602)
  • Cancer Cell Biology (111201)
  • Haematological Tumours (111206)
  • Haematology (110202)
  • Health and Community Services (111708)
  • Metabolic Medicine (110107)
  • Science, Technology and Engineering Curriculum and Pedagogy (130212)
  • Education Assessment and Evaluation (130303)
  • Receptors and Membrane Biology (060110)
  • Medical and Health Sciences (119999)
  • Vision Science (111303)
  • Medical Biochemistry and Metabolomics (110199)
  • Epigenetics (incl. Genome Methylation and Epigenomics) (060404)
  • Genetics (060499)
  • Visual Arts and Crafts (190599)
  • Cell Metabolism (060104)
  • Traditional Chinese Medicine and Treatments (110404)
  • Computer-Human Interaction (080602)
  • Medical Bacteriology (110801)
  • Pharmacogenomics (111505)
  • Exercise Physiology (110602)
  • Clinical and Sports Nutrition (111101)
  • Cellular Immunology (110704)
  • Food Engineering (090802)
  • Cell Physiology (111601)
  • Tumour Immunology (110709)

Research Impact

  • Digestive System Disorders (920105)
  • Respiratory System and Diseases (incl. Asthma) (920115)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Nervous System and Disorders (920111)
  • Public Health (excl. Specific Population Health) (920499)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Disease Distribution and Transmission (incl. Surveillance and Response) (920404)
  • Immune System and Allergy (920108)
  • Expanding Knowledge in the Biological Sciences (970106)
  • Diagnostic Methods (920203)
  • Clinical Health (Organs, Diseases and Abnormal Conditions) (920199)
  • Health Status (e.g. Indicators of Well-Being) (920408)
  • Human Pharmaceutical Treatments (e.g. Antibiotics) (860803)
  • Infectious Diseases (920109)
  • Cancer and Related Disorders (920102)
  • Injury Control (920409)
  • Child Health (920501)
  • Workforce Transition and Employment (939908)
  • Learner and Learning Processes (930102)
  • Teaching and Instruction Technologies (930203)
  • Education and Training (939999)
  • Nursing (920210)
  • Personnel (810109)
  • Blood Disorders (920101)
  • Social Structure and Health (920413)
  • Emerging Defence Technologies (810104)
  • Aboriginal and Torres Strait Islander Health - Determinants of Health (920301)

Publications

The collective impact of CIA Eri's contribution is highlighted by numerous worldwide collaborations with clinicians and researchers, invitations to speak at international meetings, invited reviews, as well as editorial and refereeing work. To cite a few examples, he was invited to edit an edition of Frontiers in Immunology, organised and  chaired  sessions at Gastroenterological Society of Australia (GESA) annual meetings, invited to speak at a number of conferences in Australia.  He published in prestigious journals (PLoS medicine, J Exp Med, Gut, BMJ). His work is widely cited (a total of ~ 1500 citations) with an average of more than 26 citations/paper and more than 350 citations for the highest cited paper.

Total publications

49

Highlighted publications

(7 outputs)
YearTypeCitationAltmetrics
2015Journal ArticleWang R, Hasnain SZ, Tong H, Das I, Che-Hao Chen A, et al., 'Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model', Inflammatory Bowel Diseases, 21, (5) pp. 973-84. ISSN 1078-0998 (2015) [Refereed Article]

DOI: 10.1097/MIB.0000000000000353 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

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2014Journal ArticleAlkadhi S, Kunde D, Cheluvappa R, Randall-Demllo S, Eri R, 'The murine appendiceal microbiome is altered in spontaneous colitis and its pathological progression', Gut pathogens, 6 Article 25. ISSN 1757-4749 (2014) [Refereed Article]

DOI: 10.1186/1757-4749-6-25 [eCite] [Details]

Citations: Scopus - 3Web of Science - 2

Co-authors: Kunde D; Randall-Demllo S

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2013Journal ArticleDas I, Png CW, Oancea I, Hasnain SZ, Lourie R, et al., 'Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins', The Journal of Experimental Medicine, 210, (6) pp. 1201-1216. ISSN 0022-1007 (2013) [Refereed Article]

DOI: 10.1084/jem.20121268 [eCite] [Details]

Citations: Scopus - 18Web of Science - 11

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2013Journal ArticleOancea I, Png CW, Das I, Lourie R, Winkler I, et al., 'A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity', Gut: An International Journal of Gastroenterology and Hepatology, 62, (4) pp. 594-605. ISSN 0017-5749 (2013) [Refereed Article]

DOI: 10.1136/gutjnl-2012-302274 [eCite] [Details]

Citations: Scopus - 12Web of Science - 11

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2008Journal ArticleEri RD, Heazlewood CK, Cook MC, Price GR, Tauro SB, et al., 'Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis', PLoS Med, 5, (3) pp. E54. ISSN 1549-1676 (2008) [Refereed Article]

DOI: 10.1371/journal.pmed.0050054 [eCite] [Details]

Citations: Scopus - 275Web of Science - 58

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2005Journal ArticleFukata M, Michelsen KS, Eri RD, Thomas LS, Hu B, et al., 'Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis', American Journal of Physiology: Gastrointestinal and Liver Physiology, 288, (5) pp. 1055-1065. ISSN 0193-1857 (2005) [Refereed Article]

DOI: 10.1152/ajpgi.00328.2004 [eCite] [Details]

Citations: Scopus - 321Web of Science - 247

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1999Journal ArticleEri RD, Arnold J, Hinman V, Green K, Jones M, et al., 'Hemps, a novel EGF-like protein plays a central role in ascidian metamorphosis', Development (Cambridge), 126, (24) pp. 5809-5818 . ISSN 0950-1991 (1999) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 53

Journal Article

(37 outputs)
YearCitationAltmetrics
2016Booth C, Cheluvappa R, Bellinson Z, Maguire D, Zimitat C, et al., 'Empirical evaluation of a virtual laboratory approach to teach lactate dehydrogenase enzyme kinetics', Annals of Medicine and Surgery, 8 pp. 6-13. ISSN 2049-0801 (2016) [Refereed Article]

DOI: 10.1016/j.amsu.2016.04.019 [eCite] [Details]

Co-authors: Booth C; Zimitat C

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2016Douglas T, Salter S, Iglesias M, Dowlman M, Eri R, 'The feedback process: Perspectives of first and second year undergraduate students in the disciplines of education, health science and nursing', Journal of University Teaching & Learning Practice, 13, (1) ISSN 1449-9789 (2016) [Refereed Article]

[eCite] [Details]

Co-authors: Douglas T; Salter S; Iglesias M; Dowlman M

2016Rahman AA, Robinson AM, Brookes SJH, Eri R, Nurgali K, 'Rectal prolapse in Winnie mice with spontaneous chronic colitis: changes in intrinsic and extrinsic innervation of the rectum', Cell and tissue research ISSN 0302-766X (2016) [Refereed Article]

DOI: 10.1007/s00441-016-2465-z [eCite] [Details]

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2016Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, et al., 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)', Autophagy, 12, (1) pp. 1-222. ISSN 1554-8627 (2016) [Refereed Article]

DOI: 10.1080/15548627.2015.1100356 [eCite] [Details]

Citations: Web of Science - 67

Co-authors: Randall-Demllo S

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2015Rahman AA, Robinson AM, Jovanovska V, Eri RD, Nurgali K, 'Alterations in the distal colon innervation in Winnie mouse model of spontaneous chronic colitis', Cell and Tissue Research, 362, (3) pp. 497-512. ISSN 0302-766X (2015) [Refereed Article]

DOI: 10.1007/s00441-015-2251-3 [eCite] [Details]

Citations: Scopus - 2Web of Science - 1

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2015Cheluvappa R, Eri R, 'Conjugate products of pyocyanin-glutathione reactions', Chemico-Biological Interactions: a journal of molecular, cellular and biochemical toxicology, 238 pp. 91-92. ISSN 0009-2797 (2015) [Letter or Note in Journal]

DOI: 10.1016/j.cbi.2015.06.002 [eCite] [Details]

Citations: Scopus - 1

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2015Eapen MS, Shukla SD, Mahmood MQ, McAlinden-Volkovickas KD, Eri RD, et al., 'Current understanding of corticosteroid therapy in chronic obstructive pulmonary disease (COPD): an overview', International Journal of Medical and Biological Frontiers, 21, (1) ISSN 1081-3829 (2015) [Non Refereed Article]

[eCite] [Details]

Co-authors: Eapen MS; Shukla SD; Mahmood MQ; McAlinden-Volkovickas KD; Walters EH; Sohal SS

2015Fox MJ, Ahuja KDK, Robertson IK, Ball MJ, Eri RD, 'Can probiotic yogurt prevent diarrhoea in children on antibiotics? A double-blind, randomised, placebo-controlled study', BMJ, 5, (1) Article e006474. ISSN 1756-1833 (2015) [Refereed Article]

DOI: 10.1136/bmjopen-2014-006474 [eCite] [Details]

Citations: Scopus - 6Web of Science - 7

Co-authors: Fox MJ; Ahuja KDK; Robertson IK; Ball MJ

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2015Lean QY, Eri RD, Fitton JH, Patel RP, Gueven N, 'Fucoidan extracts ameliorate acute colitis', PLoS One, 10, (6) Article e0128453. ISSN 1932-6203 (2015) [Refereed Article]

DOI: 10.1371/journal.pone.0128453 [eCite] [Details]

Citations: Scopus - 7Web of Science - 4

Co-authors: Lean QY; Patel RP; Gueven N

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2015Ashworth Briggs EL, Toh TY, Eri RD, Hewitt A, Cook AL, 'TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients', Molecular Vision, 21 pp. 1162-1172. ISSN 1090-0535 (2015) [Refereed Article]

[eCite] [Details]

Co-authors: Ashworth Briggs EL; Hewitt A; Cook AL

2015Lean QY, Gueven N, Eri RD, Bhatia R, Sohal SS, et al., 'Heparins in ulcerative colitis: proposed and potential reasons for inconsistent clinical outcomes', Expert Review of Clinical Pharmacology, 8, (6) pp. 795-811. ISSN 1751-2433 (2015) [Refereed Article]

DOI: 10.1586/17512433.2015.1082425 [eCite] [Details]

Co-authors: Lean QY; Gueven N; Sohal SS; Stewart N; Peterson GM; Patel RP

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2015Cheluvappa R, Eri R, Luo AS, Grimm MC, 'Modulation of interferon activity-associated soluble molecules by appendicitis and appendectomy limits colitis-identification of novel anti-colitic targets', Journal of Interferon and Cytokine Research, 35, (2) pp. 108-115. ISSN 1079-9907 (2015) [Refereed Article]

DOI: 10.1089/jir.2014.0091 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2015Wang R, Hasnain SZ, Tong H, Das I, Che-Hao Chen A, et al., 'Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model', Inflammatory Bowel Diseases, 21, (5) pp. 973-84. ISSN 1078-0998 (2015) [Refereed Article]

DOI: 10.1097/MIB.0000000000000353 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Tweet

2015Lean QY, Eri RD, Randall-Demllo S, Sohal SS, Stewart N, et al., 'Orally Administered Enoxaparin Ameliorates Acute Colitis by Reducing Macrophage-Associated Inflammatory Responses', PLoS One, 10, (7) Article e0134259. ISSN 1932-6203 (2015) [Refereed Article]

DOI: 10.1371/journal.pone.0134259 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Lean QY; Randall-Demllo S; Sohal SS; Stewart N; Peterson GM; Patel RP

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2014Alkadhi S, Kunde D, Cheluvappa R, Randall-Demllo S, Eri R, 'The murine appendiceal microbiome is altered in spontaneous colitis and its pathological progression', Gut pathogens, 6 Article 25. ISSN 1757-4749 (2014) [Refereed Article]

DOI: 10.1186/1757-4749-6-25 [eCite] [Details]

Citations: Scopus - 3Web of Science - 2

Co-authors: Kunde D; Randall-Demllo S

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2014Cheluvappa R, Eri R, Luo AS, Grimm MC, 'Endothelin and vascular remodelling in colitis pathogenesis - Appendicitis and appendectomy limit colitis by suppressing endothelin pathways', International Journal of Colorectal Disease, 29, (11) pp. 1321-1328. ISSN 0179-1958 (2014) [Refereed Article]

DOI: 10.1007/s00384-014-1974-z [eCite] [Details]

Citations: Scopus - 1

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2014Eri R, 'Peer observation of teaching: reflections of an early career academic', Universal Journal of Educational Research, 2, (9) pp. 625-631. ISSN 2332-3205 (2014) [Refereed Article]

[eCite] [Details]

2014Eri R, Cook A, Brown N, 'Reflections on the value of mapping the final theory examination in a molecular biochemistry unit', Journal of Microbiology and Biology Education, 15, (1) pp. 53-54. ISSN 1935-7885 (2014) [Refereed Article]

DOI: 10.1128/jmbe.v15i1.679 [eCite] [Details]

Co-authors: Cook A; Brown N

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2013Das I, Png CW, Oancea I, Hasnain SZ, Lourie R, et al., 'Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins', The Journal of Experimental Medicine, 210, (6) pp. 1201-1216. ISSN 0022-1007 (2013) [Refereed Article]

DOI: 10.1084/jem.20121268 [eCite] [Details]

Citations: Scopus - 18Web of Science - 11

Tweet

2013Oancea I, Png CW, Das I, Lourie R, Winkler I, et al., 'A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity', Gut: An International Journal of Gastroenterology and Hepatology, 62, (4) pp. 594-605. ISSN 0017-5749 (2013) [Refereed Article]

DOI: 10.1136/gutjnl-2012-302274 [eCite] [Details]

Citations: Scopus - 12Web of Science - 11

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2013Shabala L, Walker EJ, Eklund A, Randall-Demllo S, Shabala S, et al., 'Exposure of colonic epithelial cells to oxidative and endoplasmic reticulum stress causes rapid potassium efflux and calcium influx', Cell Biochemistry and Function, 31, (7) pp. 603-611. ISSN 1099-0844 (2013) [Refereed Article]

DOI: 10.1002/cbf.2946 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Shabala L; Walker EJ; Randall-Demllo S; Shabala S; Guven N; Cook AL

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2011Eri RD, Adams RJ, Tran TV, Tong H, Das I, et al., 'An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity', Mucosal Immunology, 4, (3) pp. 354-364. ISSN 1933-0219 (2011) [Refereed Article]

DOI: 10.1038/mi.2010.74 [eCite] [Details]

Citations: Scopus - 45Web of Science - 33

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2011McGuckin MA, Eri RD, Das I, Lourie R, Florin TH, 'Intestinal secretory cell ER stress and inflammation', Biochemical Society Transactions, 39, (4) pp. 1081-1085. ISSN 0300-5127 (2011) [Refereed Article]

DOI: 10.1042/BST0391081 [eCite] [Details]

Citations: Scopus - 14Web of Science - 12

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2010McGuckin MA, Eri RD, Das I, Lourie R, Florin TH, 'ER stress and the unfolded protein response in intestinal inflammation', American Journal of Physiology: Gastrointestinal and Liver Physiology , 298, (6) pp. G820-G832. ISSN 0193-1857 (2010) [Refereed Article]

DOI: 10.1152/ajpgi.00063.2010 [eCite] [Details]

Citations: Scopus - 71Web of Science - 59

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2009McGuckin MA, Eri RD, Simms LA, Florin TH, Radford-Smith G, 'Intestinal barrier dysfunction in inflammatory bowel diseases', Inflamm. Bowel Dis, 15, (1) pp. 100-113. ISSN 1536-4844 (2009) [Refereed Article]

DOI: 10.1002/ibd.20539 [eCite] [Details]

Citations: Scopus - 226Web of Science - 202

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2008Eri RD, Heazlewood CK, Cook MC, Price GR, Tauro SB, et al., 'Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis', PLoS Med, 5, (3) pp. E54. ISSN 1549-1676 (2008) [Refereed Article]

DOI: 10.1371/journal.pmed.0050054 [eCite] [Details]

Citations: Scopus - 275Web of Science - 58

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2008Eri RD, Kodumudi N, Summerlin D, Srinivasan M, 'Suppression of colon inflammation by CD80 blockade: Evaluation in two murine models of inflammatory bowel disease', Inflammatory Bowel Disease, 14, (4) pp. 458-470. ISSN 1536-4844 (2008) [Refereed Article]

DOI: 10.1002/ibd.20344 [eCite] [Details]

Citations: Scopus - 19Web of Science - 17

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2008O'Malley JT, Eri RD, Stritesky GL, Mathur AN, Chang HC, et al., 'STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease', Journal of Immunology, 181, (7) pp. 5062-5070. ISSN 0022-1767 (2008) [Refereed Article]

DOI: 10.4049/jimmunol.181.7.5062 [eCite] [Details]

Citations: Scopus - 16Web of Science - 15

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2007Srinivasan M, Eri RD, Zunt SL, Summerlin DJ, Brand DD, et al., 'Suppression of immune responses in collagen-induced arthritis by a rationally designed CD80-binding peptide agent', Arthritis & Rheumatism, 56, (2) pp. 498-508. ISSN 1529-0131 (2007) [Refereed Article]

DOI: 10.1002/art.22324 [eCite] [Details]

Citations: Scopus - 10Web of Science - 9

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2006Hume GE, Fowler EV, Lincoln D, Eri RD, Templeton D, et al., 'Angiotensinogen and transforming growth factor beta1: novel genes in the pathogenesis of Crohn's disease', Journal of Medical Genetics, 43, (10) pp. e51. ISSN 1468-6244 (2006) [Refereed Article]

DOI: 10.1136/jmg.2005.040477 [eCite] [Details]

Citations: Scopus - 20Web of Science - 17

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2006Michael-Robinson JM, Pandeya N, Walsh MD, Biemer-Huttmann AE, Eri RD, et al., 'Characterization of tumour-infiltrating lymphocytes and apoptosis in colitis-associated neoplasia: comparison with sporadic colorectal cancer', The Journal of Pathology, 208, (3) pp. 381-387. ISSN 1096-9896 (2006) [Refereed Article]

DOI: 10.1002/path.1895 [eCite] [Details]

Citations: Scopus - 10Web of Science - 8

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2005Fowler EV, Eri RD, Hume G, Johnstone S, Pandeya N, et al., 'GLTNFalpha and IL10 SNPs act together to predict disease behaviour in Crohn's disease', Journal of Medical Genetics, 42, (6) pp. 523-528. ISSN 1468-6244 (2005) [Refereed Article]

DOI: 10.1136/jmg.2004.027425 [eCite] [Details]

Citations: Scopus - 43Web of Science - 39

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2005Fukata M, Michelsen KS, Eri RD, Thomas LS, Hu B, et al., 'Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis', American Journal of Physiology: Gastrointestinal and Liver Physiology, 288, (5) pp. 1055-1065. ISSN 0193-1857 (2005) [Refereed Article]

DOI: 10.1152/ajpgi.00328.2004 [eCite] [Details]

Citations: Scopus - 321Web of Science - 247

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2005Srinivasan M, Lu D, Eri RD, Brand DD, Haque A, et al., 'CD80 binding polyproline helical peptide inhibits T cell activation', Journal of Biological Chemistry, 280, (11) pp. 10149-10155. ISSN 0021-9258 (2005) [Refereed Article]

DOI: 10.1074/jbc.M409521200 [eCite] [Details]

Citations: Scopus - 15Web of Science - 12

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2004Eri RD, Jonsson JR, Pandeya N, Purdie DM, Clouston AD, et al., 'CCR5-Delta32 mutation is strongly associated with primary sclerosing cholangitis', Genes and Immunity, 6, (6) pp. 444-450. ISSN 1466-4879 (2004) [Refereed Article]

DOI: 10.1038/sj.gene.6364113 [eCite] [Details]

Citations: Web of Science - 35

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1999Eri RD, Arnold J, Hinman V, Green K, Jones M, et al., 'Hemps, a novel EGF-like protein plays a central role in ascidian metamorphosis', Development (Cambridge), 126, (24) pp. 5809-5818 . ISSN 0950-1991 (1999) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 53

1997Arnold J, Eri RD, Degnan B, Lavin MF, 'Novel gene containing multiple epidermal growth factor-like motifs transiently expressed in the papillae of the ascidian tadpole larvae', Developmental Dynamics, 210, (3) pp. 264-273. ISSN 1058-8388 (1997) [Refereed Article]

DOI: 10.1002/(SICI)1097-0177(199711)210:3<264::AID-AJA7>3.3.CO;2-D [eCite] [Details]

Citations: Web of Science - 16

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Chapter in Book

(3 outputs)
YearCitationAltmetrics
2016Lean QY, Gueven N, Eri RD, Peterson GM, Patel RP, 'Non-Anticoagulant Oligosaccharides of Enoxaparin Relieve Chemical-Induced Acute Colitis', Advances in Medicine and Biology, Nova Science Publishers, LV Berhardt (ed), United States, pp. 87-104. ISBN 978-1-63483-988-4 (2016) [Research Book Chapter]

[eCite] [Details]

Co-authors: Lean QY; Gueven N; Peterson GM; Patel RP

2015Eapen MS, Shukla SD, Mahmood MQ, McAlinden-Volkovickas KD, Eri RD, et al., 'Role of corticosteroids in chronic obstructive pulmonary disease (COPD)', Corticosteroids and Steroid Therapy: New Research, Nova Science Publishers, C Adkins (ed), pp. 1-40. ISBN 978-1634823081 (2015) [Research Book Chapter]

[eCite] [Details]

Co-authors: Eapen MS; Shukla SD; Mahmood MQ; McAlinden-Volkovickas KD; Walters EH; Sohal SS

2012Eri RD, McGuckin MA, Wadley R, 'T cell transfer model of colitis: a great tool to assess the contribution of T cells in chronic intestinal inflammation', Leucocytes: Methods and Protocols, Methods in Molecular Biology, Humana Press: Springer Science + Business Media, Robert B. Ashman (ed), United States, pp. 261-275. ISBN 978-1-61779-526-8 (2012) [Research Book Chapter]

DOI: 10.1007/978-1-61779-527-5_19 [eCite] [Details]

Citations: Scopus - 11

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Review

(6 outputs)
YearCitationAltmetrics
2013Basheer W, Kunde DA, Eri RD, 'Role of Chemokine Ligand CCL20 and its Receptor CCR6 in lntestinal Inflammation', Immunology and Infectious Diseases, 1, (2) pp. 30-37. ISSN 2333-2719 (2013) [Substantial Review]

DOI: 10.13189/iid.2013.010203 [eCite] [Details]

Co-authors: Basheer W; Kunde DA

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2013Eri RD, Chieppa M, 'Messages from the inside. The dynamic environment that favors intestinal homeostasis', Frontiers in Immunology, 4 pp. 1-7. ISSN 1664-3224 (2013) [Substantial Review]

DOI: 10.3389/fimmu.2013.00323 [eCite] [Details]

Citations: Scopus - 6

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2013Fox M, Ahuja KDK, Eri RD, 'Efficacy of probiotics in the prevention of antibiotic-associated diarrhoea (AAD) in children - a review', International Journal of Probiotics and Prebiotics, 8, (2/3) pp. 61-66. ISSN 1555-1431 (2013) [Substantial Review]

[eCite] [Details]

Co-authors: Fox M; Ahuja KDK

2013Lee AYS, Eri RD, Lyons AB, Grimm MC, Korner H, 'CC chemokine ligand 20 and its cognate receptor CCR6 in mucosal T cell immunology and inflammatory bowel disease: odd couple or axis of evil?', Frontiers in Immunology, 4, (194) pp. 1-7. ISSN 1664-3224 (2013) [Substantial Review]

DOI: 10.3389/fimmu.2013.00194 [eCite] [Details]

Citations: Scopus - 20

Co-authors: Lee AYS; Lyons AB; Korner H

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2013Randall-Demllo S, Chieppa M, Eri RD, 'Intestinal epithelium and autophagy: partners in gut homeostasis', Frontiers in Immunology, 4 pp. 1-14. ISSN 1664-3224 (2013) [Substantial Review]

DOI: 10.3389/fimmu.2013.00301 [eCite] [Details]

Citations: Scopus - 18

Co-authors: Randall-Demllo S

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2013Ranson NM, Eri RD, 'The Role of Inflammasomes in Intestinal Inflammation', American Journal of Medical and Biological Research, 1, (3) pp. 64-76. ISSN 2328-4080 (2013) [Substantial Review]

DOI: 10.12691/ajmbr-1-3-3 [eCite] [Details]

Co-authors: Ranson NM

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Conference Publication

(2 outputs)
YearCitationAltmetrics
2014Cook AL, Ashworth Briggs EL, Toh T, Eri RD, Hewitt A, 'Defining conditions to direct human pluripotent stem cells towards the glaucoma-affected trabecular meshwork cell lineage', 2014 Australian Health and Medical Research Congress (AHMRC), 16-19 November, 2014, Melbourne, Australia (2014) [Conference Extract]

[eCite] [Details]

Co-authors: Cook AL; Ashworth Briggs EL; Hewitt A

2014Fox MJ, Ahuja KDK, Robertson IK, Ball MJ, Eri RD, 'Probiotic yoghurt and incidence of diarrhoea in children: a double blind, randomised, controlled trial', Thirty-Eighth Annual Scientific Meeting of The Nutrition Society of Australia, 26 - 28 November, 2014, Hobart, Tasmania (2014) [Conference Extract]

[eCite] [Details]

Co-authors: Fox MJ; Ahuja KDK; Robertson IK; Ball MJ

Other Public Output

(1 outputs)
YearCitationAltmetrics
2014Simpson H, Duers L, Rankin J, McFadyen J, Campbell SJ, et al., 'Health Benchmarking Project Final Report', University of Tasmania and University of the West of Scotland, pp. 1-45. (2014) [Government or Industry Research]

[eCite] [Details]

Co-authors: Campbell SJ; Stirling CM; Walsh K; Ford K; Geraghty DP; Williams AD; Robinson AL; Miller AB; Cross M; McKay AJ; Sondermeyer J; Elmer SL; Cooper JF; Booth S

Grants & Funding

Funding Summary

Number of grants

17

Total funding

$1,156,680

Projects

Anti-inflammatory efficacy of Marinovas Fucoidan & interactions with microbiota (2016)$100,000
Description
Industry interaction to develop Marinovas fucoidan extracts for gut health
Funding
Department of Industry, Innovation and Science ($50,000); Marinova Pty Ltd ($50,000)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Guven N; Eri RD; Ahuja KDK; Ball MJ; Ambrose M; Roddam LF; Zosky GR
Year
2016
Exploring the mechanisms responsible for the early transformation from chronic colitis to colorectal cancer (2016)$28,000
Description
This project will be the first study to model early changes in inflammation-associated colitis without the need for carcinogentreatment, which mirrors the clinical situation of human colitis. The project will study the histological and biochemical changes associated with the development of colorectal cancer in this mouse model that closely resembles the development seen in humans. The project will also investigate the mirobiome changes in the progression.
Funding
Cancer Council of Tasmania ($28,000)
Scheme
Grant-Cancer Research
Administered By
University of Tasmania
Research Team
Kunde DA; Eri RD; Holloway AF
Year
2016
Epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): role in both airway fibrosis and lung cancer (2016)$39,206
Description
Small airway fibrosis is the main contributor to physiological airway obstruction in COPD. The other main airway pathology in COPD is lung cancer; up to 70% of smoking related lung cancer occurs in mild-moderate COPD. EMT may underlie both pathological features; if true this opens up major new therapeutic possibilities. We aim to investigate EMT in airways of smokers and COPD.
Funding
Clifford Craig Medical Research Trust ($39,206)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Sohal SS; Chia Collin; Larby J; Haug G; Eri RD; Myers SA; Noor WD
Year
2016
Fucoidan and stem cell mobilisation (2015)$54,095
Description
Industry interaction to test if Marinova's fucoidan extracts mobilise stem cells.
Funding
Marinova Pty Ltd ($54,095)
Scheme
Clinical Trial
Administered By
University of Tasmania
Research Team
Guven N; Eri RD; Ahuja KDK; Patel RP
Year
2015
Making sense of biology data through artistic interactions (2015)$6,856
Description
This project draws on latest research results from the fields of visual arts, visualisation, health and education and aims to design and evaluate artistic interaction methods. It is hypothesised that by introducing artistic interactions, users will be more engaged with the sense-making process, thus making the visualisation more effective in conveying the embedded information to the end users, in comparison with traditional reality based interactions.
Funding
University of Tasmania ($6,856)
Scheme
Grant-Cross-Disciplinary Incentive
Administered By
University of Tasmania
Research Team
Bywaters MC; Huang W; Fan S; Lehman KF; Eri RD
Year
2015
Fucoidan and gut health (2015)$100,000
Description
This project represents industry interaction to develop Marinovas fucoidan extract for gut health.
Funding
Department of Industry and Science ($50,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Guven N; Davis E; Eri RD; Patel RP
Year
2015
Non anticoagulant molecules of heparin for the management of ulcerative colitis (2015)$15,000
Description
This project aims to achieve the identification and evaluation of non-anticoagulant molecules of heparin that are responsible for the observed beneficial effects of heparin in patients with ulcerative colitis as well as to compare potential biomarkers in a preclinical muse model with ulcerative colitis patients.
Funding
Royal Hobart Hospital Research Foundation ($15,000)
Scheme
Grant-Clinical Research
Administered By
University of Tasmania
Research Team
Patel RP; Guven N; Eri RD; Bhatia R
Year
2015
Investigation of carcinogenesis pathways in colitis-associated colorectal cancer (2014)$7,000
Funding
Department of Health and Human Services Tasmania ($7,000)
Scheme
Donation - Individual
Administered By
University of Tasmania
Research Team
Eri RD
Year
2014
Extracellular matrix remodelling in the glaucomatous trabecular meshwork (2014)$36,235
Description
Glaucoma is a degenerative disease attributed to progressive loss of neurons within the optic nerve. There is no cure for this disease, with treatment strategies predominantly focused on reducing intraocular pressure (IOP), which remains the only modifiable risk factor. IOP is generally considered to be due to inhibited outflow of aqueous humor, the fluid within the eye, through a specialised tissue known as the trabecular meshwork. The trabecular meshwork (TM) is highly fibrous, consisting of several layers of cells overlying extracellular matrix (ECM) structures. During normal ageing, increased ECM deposition occurs in the deeper layers of the trabecular meshwork, and this appears to be increased in glaucoma. It is not known how this occurs, but it has been speculated that changes in expression and activity of ECM remodelling proteins, typified by matrix metalloproteinases (MMPs) and their regulators, tissue inhibitor of metalloproteinases (TIMPs), may be responsible. Several studies have examined gene expression and the ECM structure in normal and glaucomatous trabecular meshwork, as well as the presence of MMPs and TIMPS in aqueous humor, but no study has attempted to correlate the extent of ECM deposition with MMP or TIMP activity using trabecular meshwork tissue and aqueous humor from the same patient.
Funding
Clifford Craig Medical Research Trust ($36,235)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Cook AL; Toh TY; Hewitt Alex; Eri RD
Year
2014
Investigation of carcinogenesis pathways in colitis-associated colorectal cancer (2014)$24,409
Description
The aims of the project are: to study the expression levels of different inflammation molecules and inflammasome components in ulcerative colities patients, UC-associated-colorectal patients, sporadic colorectal patients compared to controls; to identify the cell populations where different inflammasome components are localised.
Funding
Clifford Craig Medical Research Trust ($24,409)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Eri RD; Lloyd D; Mitchell BL; Fanning S; Ahuja KDK; Cook AL
Year
2014
The INK4 locus in glaucoma - functional assessment of the non-coding RNA gene ANRIL in patient-specific cells (2013)$27,273
Funding
Clifford Craig Medical Research Trust ($27,273)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Cook AL; Eri RD; Hewitt Alex; Toh TY
Year
2013
Understanding the role of inflammasomes in inflammatory bowel disease (IBD) (2013 - 2014)$54,546
Funding
Clifford Craig Medical Research Trust ($54,546)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Eri RD; Cook AL; Mitchell BL; Wilson Raymond
Period
2013 - 2014
Investigation of carcinogenesis pathways in colitis-associated colorectal cancer (Scholarship Sarron Randall-Demllo) (2013 - 2015)$54,000
Funding
Australian Rotary Health Research Fund ($54,000)
Scheme
Scholarship-Funding Partners
Administered By
University of Tasmania
Research Team
Eri RD; Spring K; Cook AL
Period
2013 - 2015
2013: The 16th International Congress of Mucosal Immunology (ICMI 2013) Canada 17 to 20 July 2013 (2013)$2,460
Funding
University of Tasmania ($2,460)
Scheme
Grant-Conference Support Scheme
Administered By
University of Tasmania
Research Team
Eri RD
Year
2013
Glaucoma Fibroblast Cultures (2012)$10,000
Description
The project aims to establish and bank glaucoma patient-specific fibroblast cell lines and conduct molecular analyses on these cell lines.
Funding
Centre for Eye Research Aust Ltd ($10,000)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Cook AL; Eri RD
Year
2012
International Congress of Mucosal Immunology Conference - 5 to 9 July 2011, France (June 2011) (2011)$2,100
Funding
University of Tasmania ($2,100)
Scheme
Grant-Conference Support Scheme
Administered By
University of Tasmania
Research Team
Eri RD
Year
2011
Exploring the Mechanisms of Generation of Intestinal TH17 Responses and the Mechanisms of TH17 mediated Pathology (2010 - 2012)$595,500
Funding
National Health & Medical Research Council ($595,500)
Scheme
Grant-Project
Administered By
Mater Medical Research Institute
Research Team
Eri RD; Cook M; McKenzie BS; McGuckin MA; Florin THJ
Period
2010 - 2012
Grant Reference
604304

Research Supervision

Current

9

Current

DegreeTitleCommenced
PhDInvestigation of Neoplastic Transition of the Colonic Epithelium in the Winnie Mouse Model of Spontaneous Chronic Colitis2012
PhDAnalysing the Regulatory and Effector T Cell Balance in Inflammatory Bowel Disease: Can the CCR6-CCL20 axis be exploited as a therapeutic Target2012
PhDThe Role of Inflammasomes in the Pathogenesis of Inflammatory Bowel Disease2014
MastersIdentification of genes involved in increased invasiveness of transformed non-invasive nontypeable Haemophilus influenzae (NTHi) strain with invasive strain DNA using whole genome sequencing2014
PhDSecretory Leukocyte Protease Inhibitor (SLP1) Mediated Regulation Intestinal Immunity and Inflammation: Implications in inflammatory bowel disease2015
PhDEfficacy of Pre and Probiotic Combinations in a Functional Food Delivery Format for Gut Health2015
PhDInner World of a Stressed Cell: Proteomics and bioinformatics approach to unlocking pathways during ER stress2015
PhDEfficacy Of Probiotics In Treating Infectious Diarrhea In The Elderly Population2016
PhDTargeting Wnt Signaling Pathway in the Treatment of Colorectal Cancer2016