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Matt Sharman

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Matt Sharman

Matt Sharman

Senior Lecturer in Health Sciences

Room 115, Building C, Inveresk Campus

+61 3 6324 3994 (phone)

+61 3 6324 3658 (fax)

Matt.Sharman@utas.edu.au

Dr Sharman is a Senior Lecturer in Health Sciences at the School of Health Sciences in the Faculty of Health. His current research interests are directed towards the effect that lifestyle factors, such as nutrition and exercise play in the prevention of chronic diseases, specifically Alzheimer's disease.

Career summary

Qualifications

  • PhD, University of Connecticut, USA. 2005 Thesis: Confirmation of the Guinea Pig as an Experimental Model of Inflammation in Dietary-Induced Atherosclerosis
  • Master of Arts (Nutritional Sciences/Exercise Physiology), University of Connecticut, USA. 2002 Thesis: Effects of a Ketogenic Diet on Serum Biomarkers for Cardiovascular Disease in Normal Weight Men
  • Bachelor of Arts with Honours (Human Movement Studies), First Class Honours, University of Technology Sydney, Australia. 2000 Thesis: The Transformational Shifts of Myosin Heavy Chain Isoforms in Aged Human Skeletal Muscle with Long-Term Resistance Training
  • Bachelor of Human Movement Science (Exercise Science), Southern Cross University, Australia. 1999

Biography

Dr Sharman completed his PhD in 2005 in the area of cholesterol and lipoprotein metabolism, nutritional interventions and cardiovascular disease at the University of Connecticut, USA. His Doctoral work involved two major areas. Firstly, examining the effects of a high-fat, low carbohydrate diet vs. a low-fat diet on weight loss, cardiovascular disease biomarkers and inflammatory cytokines in overweight men and women. Following on from this work, the second component of his PhD involved studying the guinea pig as a potential experimental model of evaluating vascular inflammation in dietary-induced atherosclerosis. Following his PhD, Dr Sharman completed a Postdoctoral Fellowship (2005-2010) in the field of Alzheimer's disease. During this time his research primarily focused on role of cholesterol, apoE and nutritional compounds in Alzheimer's disease pathology and prevention. After completing a postdoctoral fellowship, Dr Sharman was employed as a Lecturer in Nutrition and Dietetics (2011-2012) at Edith Cowan University. Where he was responsible for teaching Nutritional Biochemistry, Nutrients and Metabolism and Advanced Concepts in Nutrition to nutrition and dietetics students. Dr Sharman began at the University of Tasmania as a Senior Lecturer in Health Sciences in July 2012.

Research Themes

Dr Sharman's research aligns to the University's research theme of Better Health. His current research interests are directed towards understanding the role that lifestyle factors, such as nutrition and exercise play in the prevention of Alzheimer's disease. Dr Sharman has over 10 years' experience in the field of Alzheimer's disease. During this time he has concentrated on investigating the role of nutritional compounds, cholesterol and apolipoprotein E (apoE) and on Alzheimer's disease pathology and prevention. His recent research has focused on involvement in a number of key grants and areas.

1) The role of nutritional factors, such as polyphenols (green tea, curcumin) and omega-3 essential fatty acids (DHA, EPA) in the prevention of Alzheimer's disease. He was a chief investigator on an NHMRC Grant that investigated the efficacy of combinational nutritional supplement therapies in the prevention of Alzheimer's disease in a transgenic mouse model.

2) The role of apolipoprotein E (apoE) as a risk factor for Alzheimer's disease. The ε4 allele of apolipoprotein E (APOE) is currently the major genetic risk factor identified for Alzheimer's disease (AD). Previous in vivo data has demonstrated that Aβ is rapidly removed from the plasma by the liver and kidney, and that the rate of its clearance is affected by apoE. Dr Sharman performed a number of experiments to extend these findings and demonstrated that APOE genotype does affect the peripheral clearance of Aβ in APOE-targeted replacement mice that carry the human apoE isoforms.

3) A Randomised clinical trial of physical activity to delay the progression of cerebrovascular pathology. Dr Sharman is a chief investigator on this current NHMRC grant, he is responsible for the measurement of the vascular risk factors and cerebrovascular disease biomarkers.

4) The role of a presenilin 2 truncation (PS2V) in Alzheimer's Disease. Dr Sharman is a chief investigator on this current NHMRC grant, he is responsible for evaluating the role of high-cholesterol diets in guinea pigs on PS2V protein levels along with diets incorporating green tea polyphenols and omega-3 fatty acids from fish oil.

Memberships

Professional practice

  •  Nutrition Society of Australia 
  • American Society for Nutrition

Teaching

Nutrition, Physiology, Biochemistry, Alzheimer’s Disease, Metabolic Syndrome

Teaching expertise

Dr Sharman lectures in a range of units  with a focus on nutrition, biochemistry and physiology.

Teaching responsibility

CXA125 Introductory Biochemistry

CXA172 Anatomy and Physiology 1

CXA208 Human Nutrition

CXA209 Nutrition Through the Lifecycle

CXA261 Metabolic Biochemistry

CXA385 Nutrition and Disease

View more on Dr Matt Sharman in WARP

Expertise

  • Cholesterol and Lipid Metabolism in Alzheimer's disease
  • Nutritional prevention of Alzheimer's disease
  • Polyphenols (Curcumin, EGCG, Resveratrol)
  • Omega-3 Essential Fatty Acids (DHA)
  •  Exercise Interventions in Alzheimer's disease
  •  Lipoproteins and Cardiovascular disease
  •  Nutrition and Metabolic Syndrome
  • Exercise Interventions in Preventing and Management and Metabolic Syndrome
  •  Nutritional Interventions in Preventing and Management of Metabolic Syndrome
  • Biological Based Complementary and Alternative Medicines in Treatment of Chronic diseases

Awards

  • Government of Western Australia, Department of Health. New Independent Researcher Infrastructure Support (NIRIS) Award. June 2010.
  • The International Society for Neurochemistry Travel Fellowship, to attend Protein Misfolding and Neurological Disorders Meeting, Dunk Island, North Queensland, Australia, 17-19 October. 2007.
  • The Neag School of Education Outstanding Doctoral Student Research Award (University of Connecticut, 2005).
  • The Neag School of Education Outstanding Master's Student Research Award (University of Connecticut, 2003).

Collaboration

Dr Sharman has established a number of collaborations including Prof Ralph Martins (Edith Cowan University), Assoc Prof Giuseppe Verdile (Curtin University) and Prof Nicola Lautenschlager (University of Melbourne). As a result of these collaborations he is a chief investigator on 2 current NHMRC Project Grants; #APP1005942 and #APP1045507.

Current projects

  • The role of a presenilin 2 truncation (PS2V) in Alzheimer's Disease. Funded by National Health & Medical Research Council.
  • A Randomised clinical trial of physical activity to delay the progression of cerebrovascular pathology. Funded by National Health & Medical Research Council.
  • A Pilot Clinical Study to Evaluate the Efficacy of Amla Extract (Indian Gooseberry) on Raising HDL-Cholesterol and Decreasing Plasma Amyloid beta (Aβ) Levels in patients expressing low HDL-Cholesterol levels. In Collaboration with Arjuna Natural Extracts, Kerala, India. Funded by Hollywood Private Hospital Research Foundation.
  • Evaluation of the Nutritional Extract Bio-curcumin (BCM-95) to Preserve Cognitive Functioning over 12 Months. Funded by Arjuna Natural Extracts, Kerala, India.

Research Fields

  • Exercise Physiology (110602)
  • Nutrition and Dietetics (111199)
  • Neurosciences (110999)
  • Neurology and Neuromuscular Diseases (110904)
  • Biomechanics (110601)
  • Receptors and Membrane Biology (060110)
  • Respiratory Diseases (110203)
  • Cell Metabolism (060104)
  • Central Nervous System (110903)
  • Geriatrics and Gerontology (110308)
  • Nephrology and Urology (110312)
  • Complementary and Alternative Medicine (110499)

Research Impact

  • Health and Support Services (920299)
  • Nutrition (920411)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Health (929999)
  • Diabetes (920104)
  • Mental Health (920410)
  • Respiratory System and Diseases (incl. Asthma) (920115)
  • Clinical Health (Organs, Diseases and Abnormal Conditions) (920199)
  • Public Health (excl. Specific Population Health) (920499)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Preventive Medicine (920412)

Publications

As a Mid-Career Researcher Dr Sharman has > 55 publications in mid impact journals, including Journal of Nutrition, Journal of Nutritional Biochemistry, Journal of Gerontology A: Biological Sciences, Nutrition and Metabolism, Journal of the American Dietetic Association, Journal of the American College of Nutrition, Metabolism-Clinical and Experimental, Clinical Science, Medicine and Science in Sports and Exercise Science, Journal of Neurochemistry, Journal of Alzheimer's Disease, Neuroscience and Advanced Drug Delivery Reviews. In addition Dr Sharman has three book chapters in well-respected publishing agencies, including Wiley-Blackwell Scientific, CRC press and Human Kinetics. His publications have been cited over 1,462 times and he currently has an h-index of 24.

Total publications

65

Highlighted publications

(11 outputs)
YearTypeCitationAltmetrics
2013Journal ArticleLim WLF, Lam SM, Shui G, Mondal A, Ong D, et al., 'Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice', Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 34, (9) pp. 2217-2224. ISSN 0197-4580 (2013) [Refereed Article]

DOI: 10.1016/j.neurobiolaging.2013.03.012 [eCite] [Details]

Citations: Scopus - 5Web of Science - 4

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2013Journal ArticleSkleryk JR, Karagounis LG, Hawley JA, Sharman MJ, Laursen PB, et al., 'Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men', Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics, 15, (12) pp. 1146-1153. ISSN 1462-8902 (2013) [Refereed Article]

DOI: 10.1111/dom.12150 [eCite] [Details]

Citations: Scopus - 10Web of Science - 11

Co-authors: Watson G

Tweet

2013Journal ArticleSharman MJ, Moussavi Nik SH, Chen MM, Ong D, Wijaya L, et al., 'The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes', PLoS One, 8, (6) Article e66235. ISSN 1932-6203 (2013) [Refereed Article]

DOI: 10.1371/journal.pone.0066235 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Tweet

2012Journal ArticleAbbiss H, Maker GL, Gummer J, Sharman MJ, Phillips JK, et al., 'Development of a non-targeted metabolomics method to investigate urine in a rat model of polycystic kidney disease', Nephrology, 2012 Feb, (17(2)) pp. 104-10. ISSN 1320-5358 (2012) [Refereed Article]

DOI: 10.1111/j.1440-1797.2011.01532.x [eCite] [Details]

Citations: Scopus - 8Web of Science - 7

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2010Journal ArticleSharman MJ, Morici M, Hone E, Berger T, Taddei K, et al., 'APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice', Journal of Alzheimer's Disease, 2010, (21(2)) pp. 403-9. ISSN 1387-2877 (2010) [Refereed Article]

DOI: 10.3233/JAD-2010-100141 [eCite] [Details]

Citations: Scopus - 21Web of Science - 20

Tweet

2009Journal ArticleMartins IJ, Berger T, Sharman MJ, Verdile G, Fuller SJ, et al., 'Cholesterol Metabolism and Transport in the Pathogenesis of Alzheimer's disease', Journal of Neurochemistry, 2009 Dec, (111(6)) pp. 1275-308. ISSN 0022-3042 (2009) [Refereed Article]

DOI: 10.1111/j.1471-4159.2009.06408.x [eCite] [Details]

Citations: Scopus - 91Web of Science - 88

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2008Journal ArticleMaczurek A, Hager K, Kenklies M, Sharman MJ, Martins R, et al., 'Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease', Advanced Drug Delivery Reviews, 2008 Oct-Nov, (60(13-14)) pp. 1463-70. ISSN 0169-409X (2008) [Refereed Article]

DOI: 10.1016/j.addr.2008.04.015 [eCite] [Details]

Citations: Scopus - 125Web of Science - 114

Tweet

2008Journal ArticleSharman MJ, Fernandez ML, Zern TL, Torres-Gonzalez M, Kraemer WJ, et al., 'Replacing dietary carbohydrate with protein and fat decreases the concentrations of small LDL and the inflammatory response induced by atherogenic diets in the guinea pig', Journal of Nutritional Biochemistry, 2008 Nov, (19(11)) pp. 732-8. ISSN 0955-2863 (2008) [Refereed Article]

DOI: 10.1016/j.jnutbio.2007.09.008 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

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2004Journal ArticleSharman MJ, Gomez AL, Kraemer WJ, Volek JS, 'Very low-carbohydrate and low-fat diets affect fasting lipids and postprandial lipemia differently in overweight men', Journal of Nutrition, 134, (4) pp. 880-5. ISSN 0022-3166 (2004) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 91

2004Journal ArticleSharman MJ, Volek JS, 'Weight loss leads to reductions in inflammatory biomarkers after a very-low-carbohydrate diet and a low-fat diet in overweight men', Clinical Science, 107 pp. 365-369. ISSN 0143-5221 (2004) [Refereed Article]

DOI: 10.1042/CS20040111 [eCite] [Details]

Citations: Web of Science - 60

Tweet

2002Journal ArticleSharman MJ, Kraemer WJ, Love DM, Avery NG, Gomez AL, et al., 'A ketogenic diet favorably affects serum biomarkers for cardiovascular disease in normal-weight men', Journal of Nutrition, 2002 Jul, (132(7)) pp. 1879-85. ISSN 0022-3166 (2002) [Refereed Article]

[eCite] [Details]

Journal Article

(56 outputs)
YearCitationAltmetrics
2015Kerestes R, Phal PM, Stewart C, Moffat BA, Salinas S, et al., 'Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease', British Journal of Psychiatry Open, 1, (2) pp. 139-148. ISSN 2044-6055 (2015) [Refereed Article]

DOI: 10.1192/bjpo.bp.115.001339 [eCite] [Details]

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2015Merkel B, Steward C, Vivash L, Malpas CB, Phal P, et al., 'Semi-automated hippocampal segmentation in people with cognitive impairment using an age appropriate template for registration', Journal of Magnetic Resonance Imaging, 42 pp. 1631-1638. ISSN 1053-1807 (2015) [Refereed Article]

DOI: 10.1002/jmri.24966 [eCite] [Details]

Citations: Scopus - 1

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2015Venigalla M, Gyengesi E, Sharman MJ, Munch G, 'Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease', Neurochemistry International ISSN 0197-0186 (2015) [Refereed Article]

DOI: 10.1016/j.neuint.2015.10.011 [eCite] [Details]

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2013Sharman MJ, Moussavi Nik SH, Chen MM, Ong D, Wijaya L, et al., 'The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes', PLoS One, 8, (6) Article e66235. ISSN 1932-6203 (2013) [Refereed Article]

DOI: 10.1371/journal.pone.0066235 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Tweet

2013Skleryk JR, Karagounis LG, Hawley JA, Sharman MJ, Laursen PB, et al., 'Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men', Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics, 15, (12) pp. 1146-1153. ISSN 1462-8902 (2013) [Refereed Article]

DOI: 10.1111/dom.12150 [eCite] [Details]

Citations: Scopus - 10Web of Science - 11

Co-authors: Watson G

Tweet

2013Lim WLF, Lam SM, Shui G, Mondal A, Ong D, et al., 'Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice', Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 34, (9) pp. 2217-2224. ISSN 0197-4580 (2013) [Refereed Article]

DOI: 10.1016/j.neurobiolaging.2013.03.012 [eCite] [Details]

Citations: Scopus - 5Web of Science - 4

Tweet

2012Abbiss H, Maker GL, Gummer J, Sharman MJ, Phillips JK, et al., 'Development of a non-targeted metabolomics method to investigate urine in a rat model of polycystic kidney disease', Nephrology, 2012 Feb, (17(2)) pp. 104-10. ISSN 1320-5358 (2012) [Refereed Article]

DOI: 10.1111/j.1440-1797.2011.01532.x [eCite] [Details]

Citations: Scopus - 8Web of Science - 7

Tweet

2012Cyarto EV, Lautenschlager NT, Desmond PM, Ames D, Szoeke C, et al., 'Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial', BMC Psychiatry, 12 Article 167. ISSN 1471-244X (2012) [Refereed Article]

DOI: 10.1186/1471-244X-12-167 [eCite] [Details]

Citations: Scopus - 15

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2010Jenner AM, Lim WLF, Ng MP, Wenk MR, Shui G, et al., 'The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice', Neuroscience: An International Journal, 169, (1) pp. 109-115. ISSN 0306-4522 (2010) [Refereed Article]

DOI: 10.1016/j.neuroscience.2010.04.026 [eCite] [Details]

Citations: Scopus - 9Web of Science - 9

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2010Sharman MJ, Morici M, Hone E, Berger T, Taddei K, et al., 'APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice', Journal of Alzheimer's Disease, 2010, (21(2)) pp. 403-9. ISSN 1387-2877 (2010) [Refereed Article]

DOI: 10.3233/JAD-2010-100141 [eCite] [Details]

Citations: Scopus - 21Web of Science - 20

Tweet

2010Sharman MJ, Shui G, Fernandis AZ, Lim WLF, Berger T, et al., 'Profiling brain and plasma lipids in human APOE epsilon2, epsilon3, and epsilon4 knock-in mice using electrospray ionization mass spectrometry', Journal of Alzheimer'S Disease, 2010, (20(1)) pp. 105-11. ISSN 1387-2877 (2010) [Refereed Article]

DOI: 10.3233/JAD-2010-1348 [eCite] [Details]

Citations: Scopus - 10Web of Science - 9

Tweet

2009Martins IJ, Berger T, Sharman MJ, Verdile G, Fuller SJ, et al., 'Cholesterol Metabolism and Transport in the Pathogenesis of Alzheimer's disease', Journal of Neurochemistry, 2009 Dec, (111(6)) pp. 1275-308. ISSN 0022-3042 (2009) [Refereed Article]

DOI: 10.1111/j.1471-4159.2009.06408.x [eCite] [Details]

Citations: Scopus - 91Web of Science - 88

Tweet

2008Maczurek A, Hager K, Kenklies M, Sharman MJ, Martins R, et al., 'Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease', Advanced Drug Delivery Reviews, 2008 Oct-Nov, (60(13-14)) pp. 1463-70. ISSN 0169-409X (2008) [Refereed Article]

DOI: 10.1016/j.addr.2008.04.015 [eCite] [Details]

Citations: Scopus - 125Web of Science - 114

Tweet

2008Sharman MJ, Fernandez ML, Zern TL, Torres-Gonzalez M, Kraemer WJ, et al., 'Replacing dietary carbohydrate with protein and fat decreases the concentrations of small LDL and the inflammatory response induced by atherogenic diets in the guinea pig', Journal of Nutritional Biochemistry, 2008 Nov, (19(11)) pp. 732-8. ISSN 0955-2863 (2008) [Refereed Article]

DOI: 10.1016/j.jnutbio.2007.09.008 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

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2007Wood RJ, Fernandez ML, Sharman MJ, Silvestre R, Greene CM, et al., 'Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber on plasma low-density lipoprotein cholesterol and other clinical markers of cardiovascular risk', Metabolism: Clinical and Experimental, 2007 Jan, (56(1)) pp. 58-67. ISSN 0026-0495 (2007) [Refereed Article]

DOI: 10.1016/j.metabol.2006.08.021 [eCite] [Details]

Citations: Web of Science - 30

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2007Torres-Gonzalez M, Shrestha S, Sharman MJ, Freake C, Volek JS, et al., 'Carbohydrate restriction alters hepatic cholesterol metabolism in guinea pigs fed a hypercholesterolemic diet', Journal of Nutrition, 137, (10) pp. 2219-2223. ISSN 0022-3166 (2007) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 8

2006Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, et al., 'Androgenic responses to resistance exercise: effects of feeding and L-carnitine', Medicine and Science in Sports and Exercise, 2006 Oct, (38(7)) pp. 1288-1296. ISSN 0195-9131 (2006) [Refereed Article]

DOI: 10.1249/01.mss.0000227314.85728.35 [eCite] [Details]

Citations: Web of Science - 41

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2006Hatfield DL, Kraemer WJ, Volek JS, Rubin MR, Grebien B, et al., 'The effects of carbohydrate loading on repetitive jump squat power performance', Journal of Strength and Conditioning Research: The Research Journal of The National Strength and Conditioning Association, 2006 Feb, (20(1)) pp. 167-71. ISSN 1064-8011 (2006) [Refereed Article]

DOI: 10.1519/R-18300.1 [eCite] [Details]

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2006Volek JS, Silvestre R, Kirwan JP, Sharman MJ, Judelson DA, et al., 'Effects of Chromium Supplementation on Glycogen Synthesis after High-Intensity Exercise', Medicine and Science in Sports and Exercise, 2006 Dec, (38(12)) pp. 2102-9. ISSN 0195-9131 (2006) [Refereed Article]

DOI: 10.1249/01.mss.0000235353.09061.54 [eCite] [Details]

Citations: Web of Science - 3

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2006Torres-Gonzalez M, Volek J, Sharman MJ, Contois JH, Fernandez ML, 'Dietary carbohydrate and cholesterol influence the number of particles and distributions of lipoprotein subfractions in guinea pigs', Journal of Nutritional Biochemistry, 2006 Nov, (17(11)) pp. 773-9. ISSN 0955-2863 (2006) [Refereed Article]

DOI: 10.1016/j.jnutbio.2006.01.004 [eCite] [Details]

Citations: Web of Science - 8

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2005Kraemer WJ, French DN, Spiering BA, Volek JS, Sharman MJ, et al., 'Cortitrol supplementation reduces serum cortisol responses to physical stress', Metabolism: Clinical and Experimental, 2005 May, (54(5)) pp. 657-68. ISSN 0026-0495 (2005) [Refereed Article]

DOI: 10.1016/j.metabol.2004.12.010 [eCite] [Details]

Citations: Web of Science - 16

Co-authors: Watson G

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2005Kraemer WJ, Ratamess NA, Maresh CM, Anderson JA, Tiberio DP, et al., 'Effects of treatment with a cetylated fatty acid topical cream on static postural stability and plantar pressure distribution in patients with knee osteoarthritis', Journal of Strength and Conditioning Research: The Research Journal of The National Strength and Conditioning Association, 2005 Feb, (19(1)) pp. 115-21. ISSN 1064-8011 (2005) [Refereed Article]

DOI: 10.1519/5050504.1 [eCite] [Details]

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2005Greene CM, Zern TL, Wood RJ, Shrestha S, Aggarwal D, et al., 'Maintenance of the LDL cholesterol:HDL cholesterol ratio in an elderly population given a dietary cholesterol challenge', Journal of Nutrition, 2005 Dec, (135(12)) pp. 2793-8. ISSN 0022-3166 (2005) [Refereed Article]

[eCite] [Details]

2005Lofgren I, Zern T, Herron K, West K, Sharman MJ, et al., 'Weight loss associated with reduced intake of carbohydrate reduces the atherogenicity of LDL in premenopausal women', Metabolism: Clinical and Experimental, 2005 Sep, (54(9)) pp. 1133-41. ISSN 0026-0495 (2005) [Refereed Article]

DOI: 10.1016/j.metabol.2005.03.019 [eCite] [Details]

Citations: Web of Science - 17

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2005Ratamess NA, Kraemer WJ, Volek JS, Maresh CM, VanHeest JL, et al., 'Androgen receptor content following heavy resistance exercise in men', Journal of Steroid Biochemistry and Molecular Biology, 2005 Jan, (93(1)) pp. 35-42. ISSN 0960-0760 (2005) [Refereed Article]

DOI: 10.1016/j.jsbmb.2004.10.019 [eCite] [Details]

Citations: Web of Science - 55

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2005Rubin MR, Kraemer WJ, Maresh CM, Volek JS, Ratamess NA, et al., 'High-affinity growth hormone binding protein and acute heavy resistance exercise', Medicine and Science in Sports and Exercise, 2005 Mar, (37(3)) pp. 395-403. ISSN 0195-9131 (2005) [Refereed Article]

[eCite] [Details]

2005Volek JS, Sharman MJ, Forsythe CE, 'Modification of lipoproteins by very low-carbohydrate diets', Journal of Nutrition, 135, (6) pp. 1339-1342. ISSN 0022-3166 (2005) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 57

2005Kraemer WJ, Ratamess NA, Maresh CM, Anderson JA, Volek JS, et al., 'A cetylated fatty acid topical cream with menthol reduces pain and improves functional performance in individuals with arthritis', Journal of Strength and Conditioning Research: The Research Journal of The National Strength and Conditioning Association, 2005 May, (19(2)) pp. 475-80. ISSN 1064-8011 (2005) [Refereed Article]

DOI: 10.1519/R-505059.1 [eCite] [Details]

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2004French DN, Gomez AL, Volek JS, Rubin MR, Ratamess NA, et al., 'Longitudinal tracking of muscular power changes of NCAA Division I collegiate women gymnasts', Journal of Strength and Conditioning Research: The Research Journal of The National Strength and Conditioning Association, 2004 Feb, (18(1)) pp. 101-7. ISSN 1064-8011 (2004) [Refereed Article]

[eCite] [Details]

2004Herron KL, Lofgren IE, Sharman MJ, Volek JS, Fernandez ML, 'High intake of cholesterol results in less atherogenic low-density lipoprotein particles in men and women independent of response classification', Metabolism: Clinical and Experimental, 2004 Jun, (53(6)) pp. 823-30. ISSN 0026-0495 (2004) [Refereed Article]

[eCite] [Details]

2004Kraemer WJ, Gordon SE, Koziris LP, Jemiolo B, Bush JA, et al., 'Responses of plasma proenkephalin peptide F in rats following 14 days of spaceflight', Aviation, Space, and Environmental Medicine, 2004 Feb, (75(2)) pp. 114-7. ISSN 0095-6562 (2004) [Refereed Article]

[eCite] [Details]

2004Kraemer WJ, Ratamess NA, Anderson JM, Maresh CM, Tiberio DP, et al., 'Effect of a cetylated fatty acid topical cream on functional mobility and quality of life of patients with osteoarthritis', Journal of Rheumatology, 2004 Apr, (31(4)) pp. 767-74. ISSN 0315-162X (2004) [Refereed Article]

[eCite] [Details]

2004Sharman MJ, Gomez AL, Kraemer WJ, Volek JS, 'Very low-carbohydrate and low-fat diets affect fasting lipids and postprandial lipemia differently in overweight men', Journal of Nutrition, 134, (4) pp. 880-5. ISSN 0022-3166 (2004) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 91

2004Sharman MJ, Volek JS, 'Weight loss leads to reductions in inflammatory biomarkers after a very-low-carbohydrate diet and a low-fat diet in overweight men', Clinical Science, 107 pp. 365-369. ISSN 0143-5221 (2004) [Refereed Article]

DOI: 10.1042/CS20040111 [eCite] [Details]

Citations: Web of Science - 60

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2004Volek JS, Ratamess NA, Rubin MR, Gomez AL, French DN, et al., 'The effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreaching', European Journal of Applied Physiology, 91, (5-6) pp. 628-37. ISSN 1439-6319 (2004) [Refereed Article]

DOI: 10.1007/s00421-003-1031-z [eCite] [Details]

Citations: Web of Science - 24

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2004Volek JS, Sharman MJ, 'Cardiovascular and hormonal aspects of very-low-carbohydrate ketogenic diets', Obesity Research, 2004 Nov, (12 Suppl 2) pp. 115S-23S. ISSN 1071-7323 (2004) [Refereed Article]

DOI: 10.1038/oby.2004.276 [eCite] [Details]

Citations: Web of Science - 22

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2004Volek JS, Sharman MJ, Gomez AL, DiPasquale C, Roti M, et al., 'Comparison of a very low-carbohydrate and low-fat diet on fasting lipids, LDL subclasses, insulin resistance, and postprandial lipemic responses in overweight women', American College of Nutrition Journal, 23, (2) pp. 177-84. ISSN 0731-5724 (2004) [Refereed Article]

DOI: 10.1080/07315724.2004.10719359 [eCite] [Details]

Citations: Web of Science - 77

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2004Volek JS, Sharman MJ, Gomez AL, Judelson DA, Rubin MR, et al., 'Comparison of energy-restricted very low-carbohydrate and low-fat diets on weight loss and body composition in overweight men and women', Nutrition & Metabolism, 1 pp. 1-13. ISSN 1743-7075 (2004) [Refereed Article]

DOI: 10.1186/1743-7075-1-13 [eCite] [Details]

Co-authors: Watson G

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2003Avery NG, Kaiser JL, Sharman MJ, Scheett TP, Barnes DM, et al., 'Effects of vitamin E supplementation on recovery from repeated bouts of resistance exercise', Journal of Strength and Conditioning Research: The Research Journal of The National Strength and Conditioning Association, 2003 Nov, (17(4)) pp. 801-9. ISSN 1064-8011 (2003) [Refereed Article]

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2003Gomez AL, Volek JS, Rubin MR, French DN, Ratamess NA, et al., 'Physiological and functional effects of acute low-frequency hand-arm vibration', Journal of Strength and Conditioning Research: The Research Journal of The National Strength and Conditioning Association, 2003 Nov, (17(4)) pp. 686-93. ISSN 1064-8011 (2003) [Refereed Article]

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2003Kraemer WJ, Rubin MR, Hakkinen K, Nindl BC, Marx JO, et al., 'Influence of muscle strength and total work on exercise-induced plasma growth hormone isoforms in women', Journal of Science and Medicine in Sport, 2003 Sep, (6(3)) pp. 295-306. ISSN 1440-2440 (2003) [Refereed Article]

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2003Kraemer WJ, Volek JS, French DN, Rubin MR, Sharman MJ, et al., 'The effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recovery', Journal of Strength and Conditioning Research: The Research Journal of The National Strength and Conditioning Association, 2003 Aug, (17(3)) pp. 455-62. ISSN 1064-8011 (2003) [Refereed Article]

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2003McGuigan MR, Sharman MJ, Newton RU, Davie AJ, Murphy AJ, et al., 'Effect of explosive resistance training on titin and myosin heavy chain isoforms in trained subjects', Journal of Strength and Conditioning Research: The Research Journal of The National Strength and Conditioning Association, 2003 Nov, (17(4)) pp. 645-51. ISSN 1064-8011 (2003) [Refereed Article]

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2003Ratamess NA, Kraemer WJ, Volek JS, Rubin MR, Gomez AL, et al., 'The effects of amino acid supplementation on muscular performance during resistance training overreaching', Journal of Strength and Conditioning Research: The Research Journal of The National Strength and Conditioning Association, 2003 May, (17(2)) pp. 250-8. ISSN 1064-8011 (2003) [Refereed Article]

[eCite] [Details]

2003Volek JS, Gomez AL, Scheett TP, Sharman MJ, French DN, et al., 'Increasing fluid milk favourably affects bone mineral density responses to resistance training in adolescent boys', American Dietetic Association. Journal, 2003 Oct, (103(10)) pp. 1353-6. ISSN 0002-8223 (2003) [Refereed Article]

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2003Volek JS, Sharman MJ, Gomez AL, Scheett TP, Kraemer WJ, 'An isoenergetic very low carbohydrate diet improves serum HDL cholesterol and triacylglycerol concentrations, the total cholesterol to HDL cholesterol ratio and postprandial lipemic responses compared with a low fat diet in normal weight, normolipidemic women', Journal of Nutrition, 133, (9) pp. 2756-61. ISSN 0022-3166 (2003) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 58

2003Fleming J, Sharman MJ, Avery NG, Love DM, Gomez AL, et al., 'Endurance capacity and high-intensity exercise performance responses to a high fat diet', International Journal of Sport Nutrition and Exercise Metabolism, 2003 Dec, (13(4)) pp. 466-78. ISSN 1526-484X (2003) [Refereed Article]

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2002Kraemer WJ, Koziris LP, Ratamess NA, Hakkinen K, Triplett-McBride NT, et al., 'Detraining produces minimal changes in physical performance and hormonal variables in recreationally strength-trained men', Journal of Strength and Conditioning Research: The Research Journal of The National Strength and Conditioning Association, 2002 Aug, (16(3)) pp. 373-82. ISSN 1064-8011 (2002) [Refereed Article]

[eCite] [Details]

2002McGuigan MR, Kraemer WJ, Deschenes MR, Gordon SE, Kitaura T, et al., 'Statistical analysis of fiber area in human skeletal muscle', Canadian Journal of Applied Physiology, 2002 Aug, (27(4)) pp. 415-22. ISSN 1066-7814 (2002) [Refereed Article]

[eCite] [Details]

2002Sharman MJ, Kraemer WJ, Love DM, Avery NG, Gomez AL, et al., 'A ketogenic diet favorably affects serum biomarkers for cardiovascular disease in normal-weight men', Journal of Nutrition, 2002 Jul, (132(7)) pp. 1879-85. ISSN 0022-3166 (2002) [Refereed Article]

[eCite] [Details]

2002Volek JS, Sharman MJ, Love DM, Avery NG, Gomez AL, et al., 'Body composition and hormonal responses to a carbohydrate-restricted diet', Metabolism: Clinical and Experimental, 2002 Jul, (51(7)) pp. 864-70. ISSN 0026-0495 (2002) [Refereed Article]

[eCite] [Details]

2001McGuigan MRM, Bronks R, Newton RU, Sharman MJ, Graham JC, et al., 'Muscle fiber characteristics in patients with peripheral arterial disease', Medicine and Science in Sports and Exercise, 2001 Dec, (33(12)) pp. 2016-21. ISSN 0195-9131 (2001) [Refereed Article]

[eCite] [Details]

2001McGuigan MRM, Bronks R, Newton RU, Sharman MJ, Graham JC, et al., 'Resistance training in patients with peripheral arterial disease: effects on myosin isoforms, fiber type distribution, and capillary supply to skeletal muscle', Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 2001 Jul, (56(7)) pp. B302-10. ISSN 1079-5006 (2001) [Refereed Article]

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2001Rubin MR, Volek JS, Gomez AL, Ratamess NA, French DN, et al., 'Safety measures of L-carnitine L-tartrate supplementation in healthy men', Journal of Strength and Conditioning Research: The Research Journal of The National Strength and Conditioning Association, 2001 Nov, (15(4)) pp. 486-90. ISSN 1064-8011 (2001) [Refereed Article]

[eCite] [Details]

2001Sharman MJ, Newton RU, Triplett-McBride T, McGuigan MRM, McBride JM, et al., 'Changes in myosin heavy chain composition with heavy resistance training in 60- to 75-year-old men and women', European Journal of Applied Physiology, 2001 Jan-Feb, (84(1-2)) pp. 127-32. ISSN 1439-6319 (2001) [Professional, Refereed Article]

DOI: 10.1007/s004210000334 [eCite] [Details]

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2001Volek JS, Gomez AL, Love DM, Avery NG, Sharman MJ, et al., 'Effects of a high-fat diet on postabsorptive and postprandial testosterone responses to a fat-rich meal', Metabolism: Clinical and Experimental, 2001 Nov, (50(11)) pp. 1351-5. ISSN 0026-0495 (2001) [Refereed Article]

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Conference Publication

(9 outputs)
YearCitationAltmetrics
2014Sharman MJ, Ong D, Verdile G, Munch G, Wenk M, et al., 'Effect of nutritional supplement therapies in the prevention of Alzheimer's disease in a transgenic mouse model', Journal of Nutrition & Intermediary Metabolism, 4 - 6 December 2013, Brisbane, Australia, pp. 32. ISSN 2352-3859 (2014) [Conference Extract]

[eCite] [Details]

2011Sklyerk J, Karagounis L, Hawley JS, Sharman MJ, Watson G, et al., 'Comparison of short-term sprint interval vs. traditional exercise training on metabolic adaptations in sedentary overweight/obese men', 16th Annual Congress of the European College of Sport Sciences, June 2011, Liverpool, UK (2011) [Conference Extract]

[eCite] [Details]

Co-authors: Watson G

2009Mate J, Siegel R, Sharman MJ, Watson G, Laursen P, 'Comparison of liquid versus ice slurry solutions on core temperature during simulated mining conditions', Future of Fatigue in Exercise Symposium, July 2009, Katoomba, Australia (2009) [Conference Extract]

[eCite] [Details]

Co-authors: Watson G

2005French DN, Kraemer WJ, Spiering BA, Judelson DA, Hatfield DL, et al., 'Influence of Catecholamines on Muscle Force Production', American College of Sports Medicine Conference, June 2005, Nashville, Tennessee (2005) [Conference Extract]

[eCite] [Details]

Co-authors: Watson G

2004Silvestre R, Sharman MJ, Gomez AL, Judelson DA, Watson G, et al., 'A Very Low-Carbohydrate Diet Results in Greater Reductions in Body Weight, Whole Body Fat, and Trunk Fat Than a Low-Fat Diet in Overweight Subjects', Federation of American Societies for Experimental Biology Conference, April 2004, Washington, District of Columbia (2004) [Conference Extract]

[eCite] [Details]

Co-authors: Watson G

2004Volek JS, Sharman MJ, Gomez AL, French DN, Watson G, et al., 'Hormonal Responses to Energy-Restricted Very Low-Carbohydrate and Low-Fat Diets Are Related to Changes in Whole Body andTrunk Fat Mass', Federation of American Societies for Experimental Biology Conference, April 2004, Washington, District of Columbia (2004) [Conference Extract]

[eCite] [Details]

Co-authors: Watson G

2003Sharman MJ, Gomez AL, French DN, Ratamess NA, Rubin MR, et al., 'Fasting and postprandial lipid responses to a hypoenergetic ketogenic and low-fat diet in men', American College of Sports Medicine Conference, June 2003, pp. 5. (2003) [Conference Extract]

[eCite] [Details]

Co-authors: Watson G

2003Volek JS, Sharman MJ, Gomez AL, French DN, Rubin MR, et al., 'Relationship between postprandial lipemia and LDL particle size during a ketogenic diet in men', American College of Sports Medicine Conference, June 2003, pp. 5. (2003) [Conference Extract]

[eCite] [Details]

Co-authors: Watson G

2003Watson G, Kraemer WJ, Case HS, Volek JS, Stuempfle KJ, et al., 'Hormonal responses to a 160km race (Susitna 100) across frozen Alaska', American College of Sports Medicine Conference, June 2003, San Francisco, California, USA (2003) [Conference Extract]

[eCite] [Details]

Co-authors: Watson G

Grants & Funding

Over the last ten years, Dr Sharman has been a Chief Investigator on a number of grants, including four NHMRC Project Grants and three ARC Linkage-Infrastructure Equipment and Facilities Grants.

Funding Summary

Number of grants

2

Total funding

$1,175,189

Projects

The role of a presenilin 2 truncation (PS2V) in Alzheimer's Disease (2014 - 2017)$543,036
Description
The Presenilin and APP proteins are centrally important in inherited, early onset Alzheimer's disease. We have discovered that a shortened form of Presenilin protein, "PS2V", appears to increase specifically the rate at which the APP protein is cleaved to produce the "Amyloid beta" protein fragment that is found in Alzheimer's disease brains. This occurs when brain cells are under oxidative stress. Understanding this process will facilitate development of appropriate therapeutic strategies for the disease.
Funding
National Health & Medical Research Council ($543,036)
Scheme
Grant-Project
Administered By
Curtin University
Research Team
Sharman MJ
Period
2014 - 2017
Grant Reference
APP1045507
A RANDOMISED CLINICAL TRIAL OF PHYSICAL ACTIVITY TO DELAY THE PROGRESSION OF CEREBROVASCULAR PATHOLOGY (2014 - 2016)$632,153
Description
The aim of this randomised clinical trial is to establish whether a 24 months physical activity (PA) program for older adults withmemory problems can delay the progression of damage to the blood vessel system in the brain, measured on an MRI scan. It also will investigatewhether cognition, mood, quality of life, functional level, fitness and biological markers will improve with the intervention. If successful this PA programcould become part of clinical care for adults at risk of dementia.
Funding
National Health & Medical Research Council ($632,153)
Scheme
Grant-Project
Administered By
National Ageing Research Institute
Research Team
Lautenschlager N; Desmond P; Cox K; Ames D; Szoeke C; Salvado O; Sharman MJ; Ellis K; Phal P
Period
2014 - 2016
Grant Reference
APP1005942