Profiles

Stephen Tristram

UTAS Home Associate Professor Stephen Tristram
Stephen Tristram

Stephen Tristram

Director Laboratory Medicine
Senior Lecturer in Medical Microbiology

Room C213, Building C, Newnham Campus

+61 3 6324 5469 (phone)

+61 3 6324 3658 (fax)

Stephen.Tristram@utas.edu.au

The issue of antibiotic resistance is something that Associate Professor Stephen Tristram has focused on during his academic career.

Associate Professor Tristram is a Senior Lecturer in Medical Microbiology in the School of Health Sciences at the University of Tasmania. He combines teaching with an active research career that focuses on antibiotic resistance and pathogenicity of the respiratory pathogen Haemophilus influenzae. As a world-class researcher in this area, he regularly receives strains of this pathogen from colleagues all over the world who seek to understand the molecular mechanisms behind new types of antibiotic resistance.

The World Health Organization (WHO) has recently added Haemophilus influenzae to a list of priority pathogens – these are the pathogens that have such a high level of antibiotic resistance that there’s an urgent need to find new approaches to prevention and treatment.

‘There’s no vaccine for this type of Haemophilus influenzae,’ says Associate Professor Tristram.

‘Most people have heard of probiotics and their use in the gut to create a community of beneficial types of gut flora. We’re working on developing a respiratory probiotic spray that creates a healthy microbial environment in the nose and throat. These parts of the body host a range of different kinds of bacteria – including Haemophilus influenzae – that generally only cause problems if you get run-down or have another illness. Some people are at a higher risk of complications from Haemophilus influenzae – those who already have reduced lung function or children prone to chronic middle ear infections.’

The bacteria Associate Professor Tristram is working on secretes a natural compound that inhibits ‘bad bacteria’. His studies have determined that these bacteria are both incredibly safe and selective: they seem to target Haemophilus influenzae exclusively. Once introduced, they should live in the nose and throat for six to twelve months, and hopefully provide protection for this period.

‘This preventative method could be incredibly important for groups such as Indigenous Australian children, who tend to have high rates of middle ear infections. Young children who contract these illnesses early in life tend to have worse health outcomes, lower participation in school attendance, and significant impairment of language development and learning due to the effects of the illness during key learning periods.

‘Traditional antibiotic treatments kill bugs that are causing an infection, but they also tend to kill everything else in a person’s mouth, bowels and vagina – good, bad and otherwise. Antibiotic use leads to some resistant strains of bacteria remaining in the body, so their efficacy is reduced over time. If our probiotic nasal spray is a success, it will be a game-changer – allowing us to move from the use of antibiotics to a probiotic with fewer potential side-effects.’

Associate Professor Tristram enjoys the blend of research and teaching in his role at the University of Tasmania.

‘I love teaching. I make teaching interesting because I want to see my students enjoying this subject I love so much. It’s important to stimulate the minds of people who may go on to further studies to contribute to this important research. My PhD students spend 20-30 hours a week on research. This is invaluable.

‘Our work has been possible thanks to a grant we received from the Clifford Craig Foundation. When we get our preliminary concepts out and bed this down in the literature, we hope to acquire more funding. I am optimistic that we can commercialise our work and see a respiratory probiotic spray on the market in the coming years.’

Associate Professor Stephen Tristram is a Senior Lecturer in Medical Microbiology in the School of Health Sciences. He has a background in Diagnostic Pathology and retains an interest in the industry. At the University, he combines teaching with an active research career that focusses on antibiotic resistance and pathogenicity of the respiratory pathogen Haemophilus influenzae.

Biography

Stephen graduated with a Bachelor of Applied Science (Medical Laboratory Science) from the Tasmanian State Institute of Technology in 1986, and spent the next 10 years working as a microbiologist in a number of diagnostic pathology laboratories throughout Australia. He achieved a Fellowship in Microbiology with the Australian Institute of Medical Laboratory Scientists in 1994, and joined the Faculty of Health Science at the University of Tasmania in 1995. Since joining the University primarily in a teaching role, Stephen has established a successful research program culminating in a PhD in 2010.

Career summary

Qualifications

  • PhD, University of Tasmania, Australia. 2010 Thesis: New Insights into Mechanisms of B-lactam Resistance in H. influenzae
  • Master of Applied Science, Charles Sturt University, Australia. 1998
  • Fellowship in Microbiology, Australian Institute of Medical Scientists, Australia. 1994
  • Bachelor of Applied Science, University of Tasmania, Australia. 1986

Memberships

Professional practice

  • Member of the Australian Society for Microbiology
  • Member of the Australian Society for Antimicrobials
  • Fellow of the Australian Institute of Medical Scientists
  • Examiner in Microbiology for the Australian Institute of Medical Scientists

Teaching

Microbiology, infectious disease, parasitology, mycology, bacteriology

Teaching expertise

A/Prof Tristram teaches diagnostic medical microbiology with sub-specialties of bacteriology, parasitology, virology and mycology to students in the Bachelor of Laboratory Medicine, Graduate Diploma of Laboratory Medicine and Master of Laboratory Medicine.

Teaching responsibility

Medical Microbiology A

Medical Microbiology B

View more on Dr Stephen Tristram in WARP

Expertise

  • B-lactamase mediated resistance in H. influenzae
  • Non-B-lactamase mediated resistance in H. influenzae
  • Pathogenesis in H. influenzae
  • Antibiotic Susceptibility Testing

Research Themes

A/Prof Tristram's research aligns to the University's research theme of Better Health. His research interests focus on Haemophilus influenzae, which is a respiratory pathogen involved in a range of infections, including pneumonia, sinusitis and otitis media. Some of A/Prof Tristram's research has produced better methods and interpretive criteria for the laboratory detection of antibiotic resistance, which hopefully enables clinicians to prescribe more suitable antibiotics to patients. He is also working on determining the molecular mechanisms of antibiotic resistance and pathogenesis that might provide insights into why this organism continues to be a significant burden on human health. More recently A/Prof Tristram has been exploring the use of specific types of normal respiratory bacteria as “probiotics” to selectively inhibit the colonisation of the upper respiratory tract with H. influenzae and prevent opportunistic infections.

Collaboration

Stephen has consistently collaborated with international microbiologists including: Maria Paula Bajanca-Lavado and Alexandra Nunes from the Department of Infectious Disease, National Institute of Health Portugal; Bulent Bozdogan from Adnan Menderes University, Turkey; Niels Nørskov-Lauritsen from the Department of Clinical Microbiology, Aarhus University Hospital, Denmark; and Associate Professor Heidi Smith-Vaughan of the Menzies School of Health Research in the Northern Territory.

Awards

  • Australian Society for Antimicrobials Travel Award for 'Screening and Identifying BLNAR and BLPACR Strains of H. influenzae.' (2010)
  • Oxoid Australian Society for Microbiology Culture Media Award for 'Development and Evaluation of Pyocin Supplemented Chocolate Agar for the Selective Isolation of Haemophilus influenzae from Cystic Fibrosis Patients' (2008)
  • Australian Society for Antimicrobials Travel Award for 'TEM-15 ESBL and altered PBP3 in multi-resistant strains of H. parainfluenzae' (2007)
  • Australian Society for Antimicrobials Travel Award for 'Disc diffusion based screening tests for ESBLs in H. Influenzae' (2004)

Current projects

Stephen's current projects include:

  • Examining the interaction of Haemophilus species and the associated production of bacteriocins and other inhibitory substances.
  • Investigating the role of acquired macrolide resistance genes in H. influenzae
  • Examining the role and chemical nature of biofilms in H. influenzae

Fields of Research

  • Medical Bacteriology (110801)
  • Medical Biochemistry: Nucleic Acids (110105)
  • Infectious Diseases (110309)

Research Objectives

  • Infectious Diseases (920109)
  • Diagnostic Methods (920203)
  • Human Pharmaceutical Treatments (e.g. Antibiotics) (860803)

Publications

A/Prof Tristram has published widely on antimicrobial resistance in H. influenzae, primarily in the Journal of Antimicrobial Chemotherapy, and Antimicrobial Agents and Chemotherapy, which are leading international journals in the field of 'Antimicrobial Resistance'. Notable contributions to the field include the first description of an extended spectrum B-lactamase in Haemophilus spp., the first description of the sequences of small TEM B-lactamase encoding plasmids in H. influenzae and the demonstration of inter-species transfer of altered PBP3 genes as a mechanism for the spread of B-lactamase ampicillin resistance in H. influenzae.

Total publications

70

Highlighted publications

(6 outputs)
YearTypeCitationAltmetrics
2014Journal ArticleAtkins NA, Kunde DA, Zosky G, Tristram SG, 'Genotypically defined β-lactamase-negative ampicillin-resistant isolates of non-typable Haemophilus influenzae are associated with increased invasion of bronchial epithelial cells in vitro', Journal of Medical Microbiology, 63, (Pt 10) pp. 1400-3. ISSN 0022-2615 (2014) [Refereed Article]

DOI: 10.1099/jmm.0.077966-0 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Atkins NA; Kunde DA; Zosky G

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2014Journal ArticleWitherden EA, Bajanca-Lavado MP, Tristram SG, Nunes A, 'Role of inter-species recombination of the ftsI gene in the dissemination of altered penicillin-binding-protein-3-mediated resistance in Haemophilus influenzae and Haemophilus haemolyticus', Journal of Antimicrobial Chemotherapy, 69, (6) pp. 1501-1509. ISSN 0305-7453 (2014) [Refereed Article]

DOI: 10.1093/jac/dku022 [eCite] [Details]

Citations: Scopus - 15Web of Science - 15

Co-authors: Witherden EA

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2013Journal ArticleWitherden E, Tristram SG, 'Prevalence and mechanisms of B-lactam resistance in Haemophilus haemolyticus', Journal of Antimicrobial Chemotherapy, 68, (5) pp. 1049-1053. ISSN 0305-7453 (2013) [Refereed Article]

DOI: 10.1093/jac/dks532 [eCite] [Details]

Citations: Scopus - 16Web of Science - 15

Co-authors: Witherden E

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2011Journal ArticleWitherden EA, Montgomery J, Henderson B, Tristram SG, 'Prevalence and genotypic characteristics of β-lactamase-negative ampicillin-resistant Haemophilus influenzae in Australia', Journal of Antimicrobial Chemotherapy, 66, (5) pp. 1013-1015. ISSN 0305-7453 (2011) [Refereed Article]

DOI: 10.1093/jac/dkr035 [eCite] [Details]

Citations: Scopus - 15Web of Science - 12

Co-authors: Witherden EA

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2008Journal ArticleTristram SG, Pitout MJ, Forward K, Campbell S, Nichols S, et al., 'Characterization of extended-spectrum beta-lactamase-producing isolates of Haemophilus parainfluenzae', Journal of Antimicrobial Chemotherapy, 61, (3) pp. 509-514. ISSN 0305-7453 (2008) [Refereed Article]

DOI: 10.1093/jac/dkm523 [eCite] [Details]

Citations: Scopus - 26Web of Science - 20

Co-authors: Nichols S

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2007ReviewTristram SG, Appelbaum P, Jacobs M, 'Antimicrobial resistance in H. influenzae', Clinical Microbiology Reviews , 20, (2) pp. 369-389. (2007) [Substantial Review]

[eCite] [Details]

Journal Article

(38 outputs)
YearCitationAltmetrics
2019Shinde T, Vemuri R, Shastri MD, Perera AP, Tristram S, et al., 'Probiotic Bacillus coagulans MTCC 5856 spores exhibit excellent in-vitro functional efficacy in simulated gastric survival, mucosal adhesion and immunomodulation', Journal of Functional Foods, 52 pp. 100-108. ISSN 1756-4646 (2019) [Refereed Article]

DOI: 10.1016/j.jff.2018.10.031 [eCite] [Details]

Co-authors: Vemuri R; Shastri MD; Perera AP; Stanley R; Eri R

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2018Vemuri R, Gundamaraju R, Shastri MD, Shukla SD, Kalpurath K, et al., 'Gut microbial changes, interactions, and their implications on human lifecycle: An ageing perspective', BioMed Research International, 2018 Article 4178607. ISSN 2314-6133 (2018) [Refereed Article]

DOI: 10.1155/2018/4178607 [eCite] [Details]

Citations: Scopus - 7Web of Science - 7

Co-authors: Vemuri R; Shastri MD; Shukla SD; Ahuja K; Eri R

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2018Vemuri R, Shinde T, Shastri MD, Perera AP, Tristram S, et al., 'A human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics', International Journal of Medical Sciences, 15, (9) pp. 840-848. ISSN 1449-1907 (2018) [Refereed Article]

DOI: 10.7150/ijms.25004 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Vemuri R; Shastri MD; Perera AP; Ahuja KDK; Eri R

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2017Latham RD, Gell DA, Fairbairn RL, Lyons AB, Shukla SD, et al., 'An isolate of Haemophilus haemolyticus produces a bacteriocin-like substance that inhibits the growth of nontypeable Haemophilus influenzae', International Journal of Antimicrobial Agents, 49, (4) pp. 503-506. ISSN 0924-8579 (2017) [Refereed Article]

DOI: 10.1016/j.ijantimicag.2016.12.010 [eCite] [Details]

Co-authors: Latham RD; Gell DA; Lyons AB; Shukla SD

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2017Atkinson CT, Kunde DA, Tristram SG, 'Expression of acquired macrolide resistance genes in Haemophilus influenzae', Journal of Antimicrobial Chemotherapy, 72, (12) pp. 3298-3301. ISSN 0305-7453 (2017) [Refereed Article]

DOI: 10.1093/jac/dkx290 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Atkinson CT; Kunde DA

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2016Obaid NA, Tristram S, Narkowicz CK, Jacobson GA, 'Reliability of Haemophilus influenzae biofilm measurement via static method, and determinants of in vitro biofilm production', Canadian Journal of Microbiology, 62, (12) pp. 1013-1020. ISSN 0008-4166 (2016) [Refereed Article]

DOI: 10.1139/cjm-2016-0228 [eCite] [Details]

Co-authors: Narkowicz CK; Jacobson GA

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2016Singh N, Kunde DA, Tristram SG, 'Inability of Haemophilus haemolyticus to invade respiratory epithelial cells in vitro', Journal of Medical Microbiology, 65, (11) pp. 1341-1342. ISSN 0022-2615 (2016) [Contribution to Refereed Journal]

DOI: 10.1099/jmm.0.000349 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Singh N; Kunde DA

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2016Singh NK, Kunde DA, Tristram SG, 'Effect of epithelial cell type on in vitro invasion of non-typeable Haemophilus influenzae', Journal of Microbiological Methods, 129 pp. 66-69. ISSN 0167-7012 (2016) [Refereed Article]

DOI: 10.1016/j.mimet.2016.07.021 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Singh NK; Kunde DA

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2016Atkinson CT, Tristram SG, 'Antimicrobial resistance in cystic fibrosis isolates of Haemophilus influenzae', British Journal of Biomedical Science, 73, (2) pp. 87-89. ISSN 0967-4845 (2016) [Refereed Article]

DOI: 10.1080/09674845.2016.1165408 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Atkinson CT

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2015Latham R, Zhang B, Tristram S, 'Identifying Haemophilus haemolyticus and Haemophilus influenzae by SYBR Green real-time PCR', Journal of Microbiological Methods, 112 pp. 67-99. ISSN 0167-7012 (2015) [Refereed Article]

DOI: 10.1016/j.mimet.2015.03.001 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Latham R; Zhang B

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2015Atkinson CT, Kunde DA, Tristram SG, 'Acquired macrolide resistance genes in Haemophilus influenzae?', Journal of Antimicrobial Chemotherapy, 70, (8) pp. 2234-2236. ISSN 0305-7453 (2015) [Refereed Article]

DOI: 10.1093/jac/dkv093 [eCite] [Details]

Citations: Scopus - 5Web of Science - 9

Co-authors: Kunde DA

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2015Sondergaard A, Witherden EA, Norskov-Lauritsen N, Tristram SG, 'Interspecies transfer of the penicillin-binding protein 3-encoding gene ftsI between Haemophilus influenzae and Haemophilus haemolyticus can confer reduced susceptibility to β-lactam antimicrobial agents', Antimicrobial Agents and Chemotherapy, 59, (7) pp. 4339-4342. ISSN 0066-4804 (2015) [Refereed Article]

DOI: 10.1128/AAC.04854-14 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Witherden EA

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2015Obaid NA, Jacobson GA, Tristram S, 'Relationship between clinical site of isolation and ability to form biofilms in vitro in nontypeable Haemophilus influenzae', Canadian Journal of Microbiology, 61, (3) pp. 243-245. ISSN 0008-4166 (2015) [Refereed Article]

DOI: 10.1139/cjm-2014-0763 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Jacobson GA

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2014Atkins NA, Kunde DA, Zosky G, Tristram SG, 'Genotypically defined β-lactamase-negative ampicillin-resistant isolates of non-typable Haemophilus influenzae are associated with increased invasion of bronchial epithelial cells in vitro', Journal of Medical Microbiology, 63, (Pt 10) pp. 1400-3. ISSN 0022-2615 (2014) [Refereed Article]

DOI: 10.1099/jmm.0.077966-0 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Atkins NA; Kunde DA; Zosky G

Tweet

2014Witherden EA, Bajanca-Lavado MP, Tristram SG, Nunes A, 'Role of inter-species recombination of the ftsI gene in the dissemination of altered penicillin-binding-protein-3-mediated resistance in Haemophilus influenzae and Haemophilus haemolyticus', Journal of Antimicrobial Chemotherapy, 69, (6) pp. 1501-1509. ISSN 0305-7453 (2014) [Refereed Article]

DOI: 10.1093/jac/dku022 [eCite] [Details]

Citations: Scopus - 15Web of Science - 15

Co-authors: Witherden EA

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2014Zhang B, Kunde D, Tristram S, 'Haemophilus haemolyticus is infrequently misidentified as Haemophilus influenzae in diagnostic specimens in Australia', Diagnostic Microbiology and Infectious Disease, 80, (4) pp. 272-273. ISSN 0732-8893 (2014) [Refereed Article]

DOI: 10.1016/j.diagmicrobio.2014.08.016 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Zhang B; Kunde D

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2013Witherden E, Tristram SG, 'Prevalence and mechanisms of B-lactam resistance in Haemophilus haemolyticus', Journal of Antimicrobial Chemotherapy, 68, (5) pp. 1049-1053. ISSN 0305-7453 (2013) [Refereed Article]

DOI: 10.1093/jac/dks532 [eCite] [Details]

Citations: Scopus - 16Web of Science - 15

Co-authors: Witherden E

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2013Witherden EA, Kunde D, Tristram SG, 'PCR screening for the N526K substitution in isolates of Haemophilus influenzae and Haemophilus haemolyticus', Journal of Antimicrobial Chemotherapy, 68, (10) pp. 2255-2258. ISSN 0305-7453 (2013) [Refereed Article]

DOI: 10.1093/jac/dkt189 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

Co-authors: Witherden EA; Kunde D

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2012Tristram SG, Franks LR, Harvey GL, 'Sequences of small blaTEM-encoding plasmids in Haemophilus influenzae and description of variants falsely negative for blaTEM by PCR', Journal of Antimicrobial Chemotherapy, 67, (11) pp. 2621-2625. ISSN 0305-7453 (2012) [Refereed Article]

DOI: 10.1093/jac/dks264 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

Co-authors: Franks LR; Harvey GL

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2012Witherden EA, Kunde D, Tristram SG, 'An evaluation of SNP-based PCR methods for the detection of a-lactamase-negative ampicillin-resistant Haemophilus influenzae', Journal of Infection and Chemotherapy, 18, (4) pp. 451-455. ISSN 1341-321X (2012) [Refereed Article]

DOI: 10.1007/s10156-011-0356-5 [eCite] [Details]

Citations: Scopus - 5Web of Science - 4

Co-authors: Witherden EA; Kunde D

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2012Wood-Baker R, Tristram S, Latham R, Haug G, Reid D, et al., 'Molecular detection of Haemophilus influenzae in COPD sputum is superior to conventional culturing methods', British Journal of Biomedical Science, 69, (1) pp. 37-39. ISSN 0967-4845 (2012) [Refereed Article]

DOI: 10.1080/09674845.2012.11978244 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Wood-Baker R; Latham R; Reid D; Roddam LF

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2011Bradbury RS, Tristram SG, Roddam LF, Reid DW, Inglis TJJ, et al., 'Antimicrobial susceptibility testing of cystic fibrosis and non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa: a comparison of three methods', British Journal of Biomedical Science, 68, (1) pp. 1-4. ISSN 0967-4845 (2011) [Refereed Article]

DOI: 10.1080/09674845.2011.11732833 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Bradbury RS; Roddam LF; Reid DW; Champion AC

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2011Witherden EA, Montgomery J, Henderson B, Tristram SG, 'Prevalence and genotypic characteristics of β-lactamase-negative ampicillin-resistant Haemophilus influenzae in Australia', Journal of Antimicrobial Chemotherapy, 66, (5) pp. 1013-1015. ISSN 0305-7453 (2011) [Refereed Article]

DOI: 10.1093/jac/dkr035 [eCite] [Details]

Citations: Scopus - 15Web of Science - 12

Co-authors: Witherden EA

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2011Pang SM, Tristram S, Brown S, 'Salicylhydroxamic Acid Inhibits the Growth of Candida albicans', International Journal of Biological and Life Sciences, 7, (1) pp. 40-46. ISSN 2073-0527 (2011) [Refereed Article]

[eCite] [Details]

Co-authors: Brown S

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2010Tristram SG, Littlejohn R, Bradbury RS, 'blaROB-1 Location on pB1000 in Haemophilus influenzae is widespread and variable cefaclor resistance is associated with altered penicillin-binding proteins', Antimicrobial Agents and Chemotherapy, 54, (11) pp. 4945-4947. ISSN 0066-4804 (2010) [Refereed Article]

DOI: 10.1128/AAC.00263-10 [eCite] [Details]

Citations: Scopus - 10Web of Science - 11

Co-authors: Littlejohn R; Bradbury RS

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2010Warren S, Tristram S, Bradbury RS, 'Maternal and neonatal sepsis caused by Haemophilus influenzae type d', Journal of Medical Microbiology, 59, (3) pp. 370-372. ISSN 0022-2615 (2010) [Contribution to Refereed Journal]

DOI: 10.1099/jmm.0.016543-0 [eCite] [Details]

Citations: Scopus - 7Web of Science - 6

Co-authors: Bradbury RS

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2009Pang SYM, Tristram SG, Brown SC, 'An in silico model of the alternative oxidase', International Journal of Biosciences and Technology, 2, (9) pp. 139-148. ISSN 0974-3987 (2009) [Refereed Article]

[eCite] [Details]

Co-authors: Brown SC

2009Tristram SG, 'Novel blaTEM-positive ampicillin-susceptible strains of Haemophilus influenzae', Journal of Infection and Chemotherapy, 15, (5) pp. 340-342. ISSN 1437-7780 (2009) [Letter or Note in Journal]

DOI: 10.1007/s10156-009-0700-1 [eCite] [Details]

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2008Tristram SG, 'A comparison of Etest, M.I.C.Evaluator strips and CLSI broth microdilution for determining B-lactam antimicrobial susceptibility in Haemophilus influenzae', Journal of Antimicrobial Chemotherapy, 62, (6) pp. 1464-1466. ISSN 0305-7453 (2008) [Refereed Article]

DOI: 10.1093/jac/dkn365 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

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2008Tristram SG, Pitout MJ, Forward K, Campbell S, Nichols S, et al., 'Characterization of extended-spectrum beta-lactamase-producing isolates of Haemophilus parainfluenzae', Journal of Antimicrobial Chemotherapy, 61, (3) pp. 509-514. ISSN 0305-7453 (2008) [Refereed Article]

DOI: 10.1093/jac/dkm523 [eCite] [Details]

Citations: Scopus - 26Web of Science - 20

Co-authors: Nichols S

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2007Tristram SG, Burdach JG, 'Effect of cloned inhibitor resistant TEM B-lactamases on the susceptibility of H. influenzae to amoxicillin/clavulanate', Journal of Antimicrobial Chemotherapy , 60, (5) pp. 1151-1154 . ISSN 0305-7453 (2007) [Refereed Article]

DOI: 10.1093/jac/dkm311 [eCite] [Details]

Citations: Scopus - 5Web of Science - 4

Co-authors: Burdach JG

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2006Bozdogan B, Tristram SG, Appelbaum PC, 'Combination of altered PBPs and expression of cloned extended-spectrum beta-lactamases confers cefotaxime resistance in Haemophilus influenzae', Journal of Antimicrobial Chemotherapy, 57, (4) pp. 747-749. ISSN 0305-7453 (2006) [Refereed Article]

DOI: 10.1093/jac/dkl039 [eCite] [Details]

Citations: Scopus - 11Web of Science - 11

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2006Tristram SG, Nichols S, 'A multiplex PCR for β-lactamase genes of Haemophilus influenzae and description of a new blaTEM promoter variant', Journal of Antimicrobial Chemotherapy, 58, (1) pp. 183-185. ISSN 0305-7453 (2006) [Refereed Article]

DOI: 10.1093/jac/dkl150 [eCite] [Details]

Citations: Scopus - 13Web of Science - 16

Co-authors: Nichols S

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2005Tristram SG, Bozdogan B, Appelbaum PC, 'Disc diffusion-based screening tests for extended-spectrum β-lactamases in Haemophilus influenzae', Journal of Antimicrobial Chemotherapy, 55, (4) pp. 570-573. ISSN 0305-7453 (2005) [Refereed Article]

DOI: 10.1093/jac/dki036 [eCite] [Details]

Citations: Scopus - 4Web of Science - 5

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2005Tristram SG, Hawes RA, Souprounov J, 'Variation in selected regions of blaTEM genes and promoters in Haemophilus influenzae', Journal of Antimicrobial Chemotherapy, 56, (3) pp. 481-484 . ISSN 0305-7453 (2005) [Refereed Article]

DOI: 10.1093/jac/dki238 [eCite] [Details]

Citations: Scopus - 13Web of Science - 15

Co-authors: Hawes RA; Souprounov J

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2004Cocciolone RA, Tristram SG, Hewitt PM, 'Surgical masks: operative field contamination following visor-to-visor contact', ANZ Journal of Surgery, 74, (6) pp. 439-441. ISSN 1445-1433 (2004) [Refereed Article]

DOI: 10.1111/j.1445-1433.2004.03026.x [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

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2003Tristram SG, 'Effect of extended-spectrum a-lactamases on the susceptibility of Haemophilus influenzae to cephalosporins', Journal of Antimicrobial Chemotherapy, 51, (1) pp. 39-43. ISSN 0305-7453 (2003) [Refereed Article]

DOI: 10.1093/jac/dkg015 [eCite] [Details]

Citations: Scopus - 10Web of Science - 10

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1996Tristram SG, 'Book review - An Atlas of Medical Microbiology by DI Slater, T. Lo and L Narayan', Australian Journal of Medical Science, 17, (4) pp. 170-171. ISSN 1038-1643 (1996) [Letter or Note in Journal]

[eCite] [Details]

Chapter in Book

(1 outputs)
YearCitationAltmetrics
2004Tristram SG, 'Chapter 7: Haemophilus influenzae and antimicrobial susceptibility', Antimicrobial Susceptibility Testing Methods and Practices with an Australian Perspective, Australian Society for Microbiology, John Merlino (ed), Sydney, pp. 169-174. ISBN Not yet available (2004) [Revised Book Chapter]

[eCite] [Details]

Review

(3 outputs)
YearCitationAltmetrics
2007Tristram SG, Appelbaum P, Jacobs M, 'Antimicrobial resistance in H. influenzae', Clinical Microbiology Reviews , 20, (2) pp. 369-389. (2007) [Substantial Review]

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1999Tristram SG, 'Extended spectrum beta-lactamases in Haemophilus?', Australian Journal of Medical Science, 20, (2) pp. 33-41. (1999) [Substantial Review]

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1995Tristram SG, 'Extended spectrum beta-lactamases: are we losing the battle?', Australian Journal of Medical Science, 16, (1) pp. 16-25. (1995) [Substantial Review]

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Conference Publication

(28 outputs)
YearCitationAltmetrics
2017Shinde T, Tristram SG, Stanley RA, Eri RD, 'Survival, adhesion and immunomodulatory efficacy of spore-forming probiotic Bacillus coagulans', Australian Society for Microbiology National Scientific Meeting, Hobart 2017, 2-5 July, Hobart, Tasmania (2017) [Conference Extract]

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Co-authors: Stanley RA; Eri RD

2017Tristram SG, 'Haemophilus haemolyticus secretes a novel bacteriocin-like substance that inhibits nontypeable Haemophilus influenzae', Australian Society for Microbiology Annual Scientific Meeting 2017, 2-5 July, Hobart, Tasmania (2017) [Conference Extract]

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2017Williams LJ, Latham R, Dwyer RM, O'Toole RF, Tristram SG, et al., 'The Impacts of Iron Laden Particulate Matter on NTHi Growth', Australian Society for Microbiology Annual Scientific Meeting 2017, 2-5 July 2017, Hobart, Tasmania (2017) [Conference Extract]

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Co-authors: Latham R; Dwyer RM; O'Toole RF; Zosky GR

2012Tristram SG, Witherden E, 'PCR screening for beta-lactamase-negative ampicillin-resistant strains of Haemophilus influenzae', Proceedings of European Congress on Clinical Microbiology and Infectious Diseases, March-April 2012, London, pp. 1. (2012) [Conference Extract]

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Co-authors: Witherden E

2012Tristram SG, Witherden E, 'A comparison of MIC-based screening tests for betalactamase-negative ampicillin-resistant Haemophilus influenzae', Proceedings of European Congress on Clinical Microbiology and Infectious Diseases, March-April 2012, London, pp. 1. (2012) [Conference Extract]

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Co-authors: Witherden E

2012Tristram SG, Witherden E, 'Haemophilus haemolyticus as a potential reservoir for ftsI gene mutations and altered penicillin-binding protein 3 mediated resistance in Haemophilus influenzae', Proceedings of European Congress on Clinical Microbiology and Infectious Diseases, March-April 2012, London, pp. 1-2. (2012) [Conference Extract]

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Co-authors: Witherden E

2011Tristram SG, 'Susceptibility Testing of H. influenzae: is it worth bothering?', Proceedings of Australian Society for Microbiology, July 2011, Hobart, pp. 1. (2011) [Conference Extract]

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2011Tristram SG, Franks LR, 'Characterisation of Novel s-lactamase genes in Haemophilus influenzae', Proceedings of Australian Society for Microbiology, July 2011, Hobart, pp. 1. (2011) [Conference Extract]

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Co-authors: Franks LR

2010Tristram SG, Witherden E, 'Screening and Identifying BLNAR and BLPACR strains of H. influenzae', Proceedings of Australian Society for Antimicrobials, Feb 2010, Sydney (2010) [Conference Extract]

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Co-authors: Witherden E

2010Tristram SG, Witherden E, Montgomery J, Henderson B, 'Prevalence of BLNAR strains of H. influenzae in Australia', Proceedings of Australian Society for Antimicrobials, Feb 2010, Sydney (2010) [Conference Extract]

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Co-authors: Witherden E

2009Tristram SG, 'Novel s-Lactamase Positive Ampicillin Susceptible Strains of H. influenzae', Proceedings of Australian Society for Microbiology, July 2009, Perth (2009) [Conference Extract]

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2009Tristram SG, Littlejohn RR, 'Characterisation of ROB-1 producing strains of H. influenzae', Proceedings of Australian Society for Microbiology, July 2009, Perth (2009) [Conference Extract]

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Co-authors: Littlejohn RR

2008Tristram SG, Littlejohn RR, 'A Comparison of Etest , M.I.C.EvaluatorTM Strips and CLSI Microbroth Dilution for determining a-lactam Antimicrobial Susceptibility in Haemophilus influenzae', Proceedings of Australian Society for Microbiology, July 2008, Melbourne (2008) [Conference Extract]

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Co-authors: Littlejohn RR

2008Tristram SG, Rahel A, 'Development and Evaluation of Pyocin Supplemented Chocolate Agar for the Selective Isolation of Haemophilus influenzae from Cystic Fibrosis Patients', Proceedings of Australian Society for Microbiology, July 2008, Melbourne (2008) [Conference Extract]

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2007Pang SYM, Tristram SG, Brown SC, 'Can the pathogenicity of Candida spp. be related to growth rate?', Health & Medical Research Week Scientific Meeting, Launceston (2007) [Conference Extract]

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Co-authors: Brown SC

2007Tristram SG, 'Susceptibility testing of H. influenzae: is a a-lactamase test enough?', Proceedings of Australian Society for Microbiology, July 2007, Adelaide (2007) [Conference Extract]

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2007Tristram SG, 'A-Lactam Resistance in Haemophilus influenzae', Proceedings of Australian Society for Microbiology, July 2007, Adelaide (2007) [Conference Extract]

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2007Tristram SG, Burdach J, 'The effect of artificially introduced inhibitor resistant TEM a-lactamases (IRT's) on the susceptibility of H. influenzae to amoxycillin-clavulanate', Proceedings of Australian Society for Antimicrobials, Feb 2007, Melbourne (2007) [Conference Extract]

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2007Tristram SG, Davidson R, Pitroit M, 'TEM-15 ESBL and altered PBP3 in multi-resistant strains of H. parainfluenzae', Proceedings of Australian Society for Antimicrobials, Feb 2007, Melbourne (2007) [Conference Extract]

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2006Pang SYM, Tristram SG, Brown SC, 'Alternative oxidase: a possible target of anti-Candida therapy', Proceedings of Health & Medical Research Week Scientific Meeting, 7 June 2006, Launceston Australia, pp. 2. (2006) [Conference Extract]

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Co-authors: Brown SC

2005Nichols S, Tristram SG, 'Optimization of Multiples PCR to Detect blaGenes in Haemophilius influenzae', Australian Society for Microbiology , September 2005, Canberra, pp. 1. (2005) [Conference Extract]

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Co-authors: Nichols S

2005Tristram SG, Applebaum P, Bozdogan B, 'Could ESBL's Emerge in a-Lactamase Positive Amoxicillan/Clavulanate Resistant Strains of H. influenzae', Australian Society for Microbiology , September 2005, Canberra, pp. 1. (2005) [Conference Extract]

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2005Tristram SG, Applebaum P, Bozdogan B, 'Effect of Altered PBP3 on Haemophilus Influenzae expressing cloned ESBL's', Interscience Conference on Antimicrobial Agents and Chemotherapy, September 2005, New Orleans, pp. 1. (2005) [Conference Extract]

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2004Tristram SG, 'Disc diffusion based screening tests for ESBLs in H. Influenzae', Australian Society for Antimicrobials, Feb 2004, Sydney (2004) [Conference Extract]

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2004Tristram SG, Bozdogan B, Applelbaum PC, 'A screening test for ESBLs in H. Influenzae', Proceedings of Interscience Conference on Antimicrobials and Chemotherapy, Nove 2004, Washington DC ISBN 1-55581-325-9 (2004) [Conference Extract]

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2004Tristram SG, Souprounov J, 'Effect of promoter type on relative fitness of H. Influenzae and E. Coli', Proceedings of Australioan Society for Microbiology National Scientific Meeting, Oct 2004, Sydney ISSN 1324-4272 (2004) [Conference Extract]

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Co-authors: Souprounov J

2002Tristram SG, 'Extended spectrum a-lactamases in Haemophilus influenzae', Microbiology Australia, 29 September-3 October, 2002, Melbourne, pp. 35.3. ISSN 1324-4272 (2002) [Conference Extract]

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1998Tristram SG, 'Eosinophilic enteritis caused by Enterbius vermicularis', Proceedings of the 1998 National Scientific Meeting of the Australian Institute of Medical Scientists, 21-25 September 1998, Hobart, pp. S67. (1998) [Conference Extract]

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Grants & Funding

A/Prof Tristram has received regular funding from the Clifford Craig Medical Research Trust.

Funding Summary

Number of grants

20

Total funding

$406,701

Projects

Potential therapeutic value of normal throat bacteria that produce a novel inhibitory substance for the prevention of respiratory infections (2018)$19,000
Description
We have discovered a strain of a harmless bacterial species that lives in the throats of healthy people that produces a novel substance that inhibits the growth of the respiratory pathogen Haemophilus influenzae. The study involves an evaluation of the potential of this strain as a respiratory probiotic.
Funding
Clifford Craig Foundation ($19,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG; Kunde DA; Gell DA
Year
2018
Evaluation of an antibiotic-producing bacterial strain to prevent ear infections (2017)$28,863
Description
Will test the ability of a strain of Haemophilus haemolyticus discovered in a previous UTAS project to protect against middle ear type infection with Haemophilus influenzae using a mouse model.
Funding
Wesfarmers Limited ($28,863)
Scheme
Centre of Vaccines & Infectious Diseases
Administered By
University of Tasmania
Research Team
Kirkham L; Tristram SG; Latham R; Lauzon-Joset J; Scott N; Strickland D
Year
2017
Preliminary development of a probiotic to minimise respiratory infection with Haemophilus influenzae (2016)$17,636
Description
A naturally occurring bacteriocin will be engineered into Haemophilus haemolyticus. As in vitro cell culture model will then be used to evaluate the ability of the bacteriocin producing H. haemolyticus to inhibit colonisation and growth of H. influenzae.
Funding
Clifford Craig Foundation ($17,636)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG; Kunde DA; Chia Collin
Year
2016
Is Haemophilus haemolyticus a pathogen? (2015)$10,000
Description
People with respiratory tract diseases have many bacterial species present in their sputum. Haemophilus haemolyticus is frequently present but until now is assumed to be harmless. This project will investigate whether H. haemolyticus is able to cause disease.
Funding
Royal Hobart Hospital Research Foundation ($10,000)
Scheme
Grant-Starter
Administered By
University of Tasmania
Research Team
Latham R; Harkness N; Jones David; Tristram SG
Year
2015
Whole genome sequencing of non-typeable H. influenzae to unravel pathogenesis and persistence (2014)$19,000
Description
Non-typeable Haemophilus influenzae (NTHi) is a genetically diverse bacterial commensal of the upper respiratory tract that is also an important opportunistic pathogen when the host is compromised by various disease states. NTHi is a common cause of infectious exacerbations of chronic obstructive pulmonary disease (COPD), community acquired pneumonia, otitis media and sinusitis. It is difficult to estimate the annual burden of disease attributable to NTHi in Australia, however respiratory infections in general are the most common reason for the prescription of antibiotics and accounts for approximately 20 million visits to general practitioners. COPD alone accounts for approximately 10 000 deaths, 55 000 hospitalisations and $400 million in healthcare costs and otitis media is one of the most common reasons for childrens GP visits and is associated with temporary hearing impairment and learning deficits. An incomplete understanding of the pathogenesis of infection with NTHi, the absence of a vaccine, increasing antibiotic resistance and the ability to persist in the host despite treatment are all factors which compromise our ability to adequately deal with or reduce the burden of NTHi disease.
Funding
University of Tasmania ($19,000)
Scheme
Grant-Research Enhancement (REGS)
Administered By
University of Tasmania
Research Team
Kunde DA; Tristram SG
Year
2014
Macrolide resistance in patients with chronic respiratory infections (2014)$15,750
Description
This project will investigate the effect of acquired macrolide resistance genes on survival mechanisms in H. influenzae. It will: a) determine if these genes are expressed (are functional) in this organism; b) determine if these genes increase the fitness of the organism when exposed to sub-lethal concentrations of macrolides; c) determine if the presence of these genes increases the survival of the organism in the intracellular environment of respiratory epithelial cells during exposure to macrolides. It seeks to determine the level of macrolide resistance / prevalence of macrolide resistance genes in identified respiratory pathogens and the general respiratory microbial population in patients with chronic respiratory conditions in Northern Tasmania. The study investigates the longitudinal effect of macrolide therapy on the total respiratory microbial population of selected Northern Tasmanian chronic respiratory patients.
Funding
Clifford Craig Foundation ($15,750)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG; Kunde DA; Haug G; Atkinson C; Chuang M
Year
2014
Testing a new therapy against lung infections for people with cystic fibrosis (2013)$67,782
Description
P. aeruginosa uses small diffusible signal molecules called acyl-homoserine lactones (AHLs) to alter its growth, which enables it to hide from antibiotic therapies and the immune system of the host thereby preventing its eradication from the lungs. These bacterial AHL molecules can also enter and affect human cells leading to further lung damage. This project aims to demonstrate that a novel therapy that inactivates bacterial AHLs can protect human cells from these molecules. Demonstration of this is the first step in showing that this therapy can protect the lungs of people with CF from P. aeruginosa infections. In summary, this new treatment approach should at a minimum prevent a significant amount of the lung damage that occurs, resulting in better quality of life and increased life span. More importantly, this therapy also has the potential to prevent P. aeruginosa lung infections in CF.
Funding
Clifford Craig Foundation ($67,782)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Roddam LF; Cooley MA; Ambrose M; Tristram SG
Year
2013
Are altered penicillin binding proteins in H.influenzae associated with increased capacity to invade respiratory epithelial cells? (2013)$10,000
Funding
Clifford Craig Foundation ($10,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG; Kunde DA
Year
2013
An Amoeba Co-culture Assay Alternative to Mammalian Models of Bacterial Virulence Testing (2012)$26,936
Funding
The MAWA Trust ($26,936)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Champion AC; Bradbury RS; Tristram SG; Latham R
Year
2012
Resistance to Macrolide and Fluoroquinolone Antibiotics in Haemophilus Influenzae (2012)$7,273
Funding
Clifford Craig Foundation ($7,273)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG
Year
2012
Influence of Specific Prescribing Practices on the Rapid Emergence of Antibiotic Resistance in Haemophilus Influenzae (2011)$15,636
Description
The aims and objectives of this research are to: create a library of strains of H influenzae identical except for a range of specific single and multiple mutations in the first gene that are associated with emerging antibiotic resistance; perform antibiotic susceptibility tests to determine the relative contribution of specific mutations to levels of resistance; evaluate the performance of E test; design and evaluate real time PCR assays to detect the presence of specific ftsl gene mutations; perform in vitro antibiotic challenge studies to determine which antibiotics and which baseline ftsl gene mutations favour the emergence of specific types of resistant strains.
Funding
Clifford Craig Foundation ($15,636)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG
Year
2011
Development and Evaluation of Laboratory Tests to Detect Important Emerging Antibiotic Resistance in Haemophilus Influenzae (2009)$8,909
Funding
Clifford Craig Foundation ($8,909)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG; Dadson P; Nichols S
Year
2009
Development and Evaluation of New Selective Culture Medium for Isolation of Haemophilus Influenzae from Cystic Fibrosis Patients (2009)$5,842
Funding
Clifford Craig Foundation ($5,842)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG; Reid DW
Year
2009
Platypus Partnership - A Community and Science-based Conservation Programme (2007 - 2008)$50,000
Funding
Natural Heritage Trust ($50,000)
Scheme
Grant-Natural Resource Management, Northern Region
Administered By
University of Tasmania
Research Team
Geraghty DP; Stewart NJ; Woods GM; Tristram SG; Forteath GN
Period
2007 - 2008
The Acquisition of New Strains of Non-Typeable Haemophilus Influenzae Is The Leading Cause of Acute Exacerbations in Tasmanian COPD Patients (2007)$43,467
Funding
Clifford Craig Foundation ($43,467)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Roddam LF; Sanderson K; Wood-Baker R; Tristram SG; Haug G
Year
2007
Investigation of Antibiotic Sensitivity & Virulence Factors of the Tasmanian Clonal Strain of Pseudomonas aeuruginosa Isolated from Cystic Fibrosis Patients (2005)$36,000
Funding
Clifford Craig Foundation ($36,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Roddam LF; Reid DW; Champion AC; Tristram SG
Year
2005
Characterisation of Extended Spectrum B-Lactamases and Cephalosporin Resistance in Clinical Isolates of H. parainfluenzae (2005)$12,500
Funding
Clifford Craig Foundation ($12,500)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG
Year
2005
Effect of Variant Gene Expression on Antibiotic Resistance in Haemophilus Influenzae and the Implications for Dissemination of Resistance Genes (2003)$2,900
Funding
Clifford Craig Foundation ($2,900)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG
Year
2003
Genetic Variation in B-Lactamase Genes in Haemophilus Influenzae (2002)$5,000
Funding
Clifford Craig Foundation ($5,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG
Year
2002
Extended Spectrum B-Lactamase in Haemophilus (2000)$4,207
Funding
Clifford Craig Foundation ($4,207)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG
Year
2000

Research Supervision

Current

3

Completed

5

Current

DegreeTitleCommenced
PhDExposure to Iron Laden Particulate Matter Impacts on Respiratory Health2016
PhDInvestigation on the Utilization of Beneficial Microbes in Modulating the Gut Microbiota and Metabolic Profiles in Ageing2016
PhDPotential Therapeutic Value of Normal Throat Bacteria that Produce a Novel Inhibitory Substance for;;the Prevention of Respiratory Infections2017

Completed

DegreeTitleCompleted
PhDAn Investigation of the Inhibition of Non-typeable Haemophilus influenzae, by Substances Secreted by Haemophilus haemolyticus
Candidate: Roger Declan Latham
2018
PhDAcquired Macrolide Resistance Genes in Nontypeable Haemophilus influenzae
Candidate: Christopher Thomas Atkinson
2017
MastersIn vitro Invasive Ability of X and V Factor Dependent Haemophilus Species Across Different Cell Types
Candidate: Neeraj Kumar Singh
2016
PhDApplication of Infra-Red Spectroscopy to the Evaluation of Biofilm Formation and Pathogenesis of Nontypeable Haemophilus influenzae
Candidate: Najla Abdullah Obaid
2016
PhDPhenotypic and genotypic characterisation of altered penicillin-binding protein 3 (PBP3) mediated resistance in Haemophilus influenzae and Haemophilus haemolyticus
Candidate: Elizabeth Anne Witherden
2014