Brad Sutherland

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Brad Sutherland

Senior Research Fellow

Room MS2, Level 4, 440-10, Medical Sciences Precinct, Hobart CBD Campuses

+61 3 6226 7634 (phone)

Dr Brad Sutherland is a Senior Research Fellow in the School of Medicine in the Faculty of Health. His main research interests are in understanding how blood flow is regulated in the brain, identifying mechanisms of brain injury following stroke, and discovering novel therapeutic targets. He also teaches Pharmacology and Neuroscience into a number of units as part of the BPharm and BMedRes degrees.


Brad completed his PhD at the University of Otago (Dunedin, New Zealand) where he investigated the activation of inflammatory pathways in the brain after stroke. After a small stint as a Teaching Fellow in Pharmacology & Toxicology (University of Otago), he took up a Post-doctoral Research Fellowship with the Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford (Oxford, UK). During his time in Oxford, he formed an interest in the regulation of blood flow in the brain in health and disease. This led to studies investigating the interaction between brain tissue and the blood vessels, the signalling mechanisms that controlled energy delivery to the brain, and how these were disrupted in conditions such as stroke.

In mid-2016, Brad arrived at the University of Tasmania to continue his research into blood flow and brain injury following stroke. He continues to use a wide range of in vitro and in vivo models of stroke to assess mechanisms of injury to the brain and its vasculature.

Career summary



Thesis title





Heme oxygenase and the use of tin protoporphyrin in hypoxia-ischaemia-induced brain damage: mechanisms of action

University of Otago

New Zealand


BSc (1st Class Hons)

The neuroprotective effect of epigallocatechin gallate following hypoxia-ischaemia-induced brain damage and its mechanisms of action

University of Otago

New Zealand



Professional practice

  • The International Society for Cerebral Blood Flow and Metabolism (ISCBFM)
  • Australasian Neuroscience Society (ANS)


Pharmacology, Neuroscience, Stroke, Biochemistry, Physiology, Neuropathology

Teaching expertise

Brad’s expertise is in the teaching of undergraduate Pharmacology and Neuroscience. He also has experience in teaching Biochemistry, Physiology and Neuropathology and coordinating Pharmacology units. He has also supervised both undergraduate and postgraduate research projects.

Teaching responsibility

Brad regularly contributes to the teaching of:

  • Pharmacology (CSA230, CSA232, CSA234)
  • Pharmacology (CSA231, CSA233, CSA235)
  • Neuroscience B (CHP312)
  • Research Project in Health and Disease (CBA344)

View more on Dr Brad Sutherland in WARP


Over many years, Brad has developed skills in a range of techniques to investigate blood flow in the brain, and model stroke. Specifically, he has experience with multiple stroke models including intraluminal filament middle cerebral artery occlusion (MCAO) model and hypoxia-ischaemia model. He also uses in vitro models of stroke on primary cells or cell lines in culture by exposing cells to oxygen and glucose deprivation. He employs a range of techniques including light, epifluorescence, confocal and two-photon microscopy, immunohistochemistry, histology, molecular biology, and animal behaviour. He also has experience with animal MRI. These techniques can be utilised to investigate the biological basis of a range of neurological disorders.

Research Themes

Brad’s research aligns to the University’s research theme of Better Health. His research interests include understanding how blood flow is regulated in the brain, identifying mechanisms of brain injury following stroke, and discovering novel therapeutic targets that can protect the brain after stroke. He utilises a wide range of in vitro and in vivo models to assess brain function and brain injury after stroke.

Blood flow in the brain is controlled by the neurovascular unit, which is a complex interplay of cells that communicate in order to increase blood - and therefore energy – supply in areas where brain activity is occurring. This is a tightly coupled process that uses complex paracrine signalling mechanisms and is prone to injury when an insult occurs such as stroke. Brad is currently investigating the role of multiple cell types in this “neurovascular coupling” process and the mechanisms by which neurovascular dysfunction occurs during stroke.

Recently, Brad has developed an interest in the microcirculation, specifically a cell type called pericytes which exclusively reside on capillaries. These cells are involved in many brain processes including regulating blood flow in the brain and maintenance of the blood-brain barrier and may contribute to injury and repair following stroke. Brad’s ongoing studies are examining mechanisms of pericyte dysfunction following stroke.


Brad is actively involved in a number of collaborations. Locally, Brad works closely with Prof David Howells, an experienced stroke researcher, within the School of Medicine. Brad continues to collaborate with Prof Alastair Buchan, Assoc Prof James Kennedy, Assoc Prof Nicola Sibson, Assoc Prof Gabriele De Luca and Dr Karl Morten from the University of Oxford (UK) on a range of stroke and metabolism-related projects. He also collaborates with Assoc Prof Kostas Vekrellis (Bioacademy of Athens, Greece) on novel neuroprotective pathways. He has also collaborated on blood flow-related projects with Prof David Attwell (University College London, UK), Prof Brian MacVicar (University of British Columbia, Canada), Prof Martin Lauritzen (University of Copenhagen, Denmark), Dr Clare Howarth (University of Sheffield, UK), Dr Chris Martin (University of Sheffield, UK) and Dr Catherine Hall (University of Sussex, UK).

Fields of Research

  • Central Nervous System (110903)
  • Cellular Nervous System (110902)
  • Cell Physiology (111601)
  • Signal Transduction (060111)
  • Systems Physiology (111603)
  • Obstetrics and Gynaecology (111402)
  • Foetal Development and Medicine (111401)
  • Sensory Systems (110906)
  • Basic Pharmacology (111501)
  • Cardiology (incl. Cardiovascular Diseases) (110201)

Research Objectives

  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Cardiovascular System and Diseases (920103)
  • Nervous System and Disorders (920111)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Expanding Knowledge in the Biological Sciences (970106)
  • Diabetes (920104)
  • Reproductive System and Disorders (920114)
  • Child Health (920501)
  • Hearing, Vision, Speech and Their Disorders (920107)


Dr Sutherland publishes regularly in high impact journals. He has more than 30 peer-reviewed papers including papers in Nature, Brain and Journal of Cerebral Blood Flow and Metabolism. He reviews grant applications for a number of granting bodies as well papers for a wide range of neuroscience journals.

Total publications


Journal Article

(32 outputs)
2017Hadley G, Neuhaus AA, Couch Y, Beard DJ, Adriaanse BA, et al., 'The role of the endoplasmic reticulum stress response following cerebral ischemia', International journal of stroke ISSN 1747-4930 (2017) [Refereed Article]

DOI: 10.1177/1747493017724584 [eCite] [Details]


2017Howarth C, Sutherland BA, Choi HB, Martin C, Lind BL, et al., 'A critical role for astrocytes in hypercapnic vasodilation in brain', Journal of Neuroscience, 37, (9) pp. 2403-2414. ISSN 0270-6474 (2017) [Refereed Article]

DOI: 10.1523/JNEUROSCI.0005-16.2016 [eCite] [Details]

Citations: Scopus - 4Web of Science - 5


2017Percie du Sert N, Alfieri A, Allan SM, Carswell HV, Deuchar GA, et al., 'The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)', Journal of Cerebral Blood Flow and Metabolism, 37, (11) pp. 3488-3517. ISSN 0271-678X (2017) [Refereed Article]

DOI: 10.1177/0271678X17709185 [eCite] [Details]


2017Sutherland BA, Fordsmann JC, Martin C, Neuhaus AA, Witgen BM, et al., 'Multi-modal assessment of neurovascular coupling during cerebral ischaemia and reperfusion using remote middle cerebral artery occlusion', Journal of Cerebral Blood Flow and Metabolism, 37, (7) pp. 2494-2508. ISSN 1559-7016 (2017) [Refereed Article]

DOI: 10.1177/0271678X16669512 [eCite] [Details]


2017Neuhaus AA, Couch Y, Sutherland BA, Buchan AM, 'Novel method to study pericyte contractility and responses to ischaemia in vitro using electrical impedance', Journal of Cerebral Blood Flow and Metabolism, 37, (6) pp. 2013-2024. ISSN 0271-678X (2017) [Refereed Article]

DOI: 10.1177/0271678X16659495 [eCite] [Details]

Citations: Web of Science - 1


2016Sutherland BA, Neuhaus AA, Couch Y, Balami JS, DeLuca GC, et al., 'The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke', Journal of cerebral blood flow and metabolism, 36, (2) pp. 363-369. ISSN 0271-678X (2016) [Refereed Article]

DOI: 10.1177/0271678X15606722 [eCite] [Details]

Citations: Scopus - 7Web of Science - 7


2016Kapoor M, Clarkson AN, Sutherland BA, Appleton I, 'The role of antioxidants in models of inflammation: emphasis on L-arginine and arachidonic acid metabolism', Inflammopharmacology, 12, (5-6) pp. 505-19. ISSN 0925-4692 (2016) [Refereed Article]

DOI: 10.1163/156856005774382797 [eCite] [Details]

Citations: Scopus - 13


2015Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM, 'Reply: Intravenous thrombolysis for ischaemic strokes: a call for reappraisal', Brain, 138, (4) pp. e342. ISSN 0006-8950 (2015) [Letter or Note in Journal]

DOI: 10.1093/brain/awu283 [eCite] [Details]


2015Buchan AM, Karbalai HG, Sutherland BA, 'The future of stroke therapy must not be mired by past arguments', The Lancet, 386, (9994) pp. 654. ISSN 0140-6736 (2015) [Letter or Note in Journal]

[eCite] [Details]

2015Redzic ZB, Rabie T, Sutherland BA, Buchan AM, 'Differential effects of paracrine factors on the survival of cells of the neurovascular unit during oxygen glucose deprivation', International journal of stroke, 10, (3) pp. 407-414. ISSN 1747-4930 (2015) [Refereed Article]

DOI: 10.1111/ijs.12197 [eCite] [Details]

Citations: Scopus - 6Web of Science - 5


2015Balami JS, Sutherland BA, Edmunds LD, Grunwald IQ, Neuhaus AA, et al., 'A systematic review and meta-analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke', International journal of stroke, 10, (8) pp. 1168-1178. ISSN 1747-4930 (2015) [Refereed Article]

DOI: 10.1111/ijs.12618 [eCite] [Details]

Citations: Scopus - 30Web of Science - 32


2014Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM, 'Reply: Thrombolysis in acute ischaemic stroke', Brain, 137, (1) pp. e282. ISSN 0006-8950 (2014) [Letter or Note in Journal]

DOI: 10.1093/brain/awu066 [eCite] [Details]


2014Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, et al., 'Capillary pericytes regulate cerebral blood flow in health and disease', Nature, 508, (7494) pp. 55-60. ISSN 0028-0836 (2014) [Refereed Article]

DOI: 10.1038/nature13165 [eCite] [Details]

Citations: Scopus - 314Web of Science - 307


2014Neuhaus AA, Rabie T, Sutherland BA, Papadakis M, Hadley G, et al., 'Importance of preclinical research in the development of neuroprotective strategies for ischemic stroke', JAMA neurology, 71, (5) pp. 634-639. ISSN 2168-6149 (2014) [Refereed Article]

DOI: 10.1001/jamaneurol.2013.6299 [eCite] [Details]

Citations: Scopus - 17Web of Science - 16


2014Sutherland BA, Buchan AM, 'The life of Bo K. Siesjo, MD, PhD, 1930-2013', International Journal of Stroke, 9, (1) pp. 2-4. ISSN 1747-4930 (2014) [Letter or Note in Journal]

DOI: 10.1111/ijs.12237 [eCite] [Details]


2013Balami JS, Chen R, Sutherland BA, Buchan AM, 'Thrombolytic Agents for Acute Ischaemic Stroke Treatment: The Past, Present and Future', CNS & neurological disorders drug targets, 12, (2) pp. 145-154. ISSN 1871-5273 (2013) [Refereed Article]

DOI: 10.2174/18715273113129990057 [eCite] [Details]

Citations: Scopus - 12Web of Science - 9


2013Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM, 'The exact science of stroke thrombolysis and the quiet art of patient selection', Brain, 136, (Pt 12) pp. 3528-3553. ISSN 0006-8950 (2013) [Refereed Article]

DOI: 10.1093/brain/awt201 [eCite] [Details]

Citations: Scopus - 30Web of Science - 28


2013Balami JS, Sutherland BA, Buchan AM, 'Complications Associated with Recombinant Tissue Plasminogen Activator Therapy for Acute Ischaemic Stroke', CNS & neurological disorders drug targets, 12, (2) pp. 155-169. ISSN 1871-5273 (2013) [Refereed Article]

DOI: 10.2174/18715273112119990050 [eCite] [Details]

Citations: Scopus - 23Web of Science - 21


2013Sutherland BA, Buchan AM, 'Alteplase treatment does not increase brain injury after mechanical middle cerebral artery occlusion in the rat', Journal of Cerebral Blood Flow and Metabolism, 33, (11) pp. e1-7. ISSN 0271-678X (2013) [Refereed Article]

DOI: 10.1038/jcbfm.2013.148 [eCite] [Details]

Citations: Scopus - 8


2013Sutherland BA, Harrison JC, Nair SM, Sammut IA, 'Inhalation gases or gaseous mediators as neuroprotectants for cerebral ischaemia', Current drug targets, 14, (1) pp. 56-73. ISSN 1389-4501 (2013) [Refereed Article]

DOI: 10.2174/1389450111314010007 [eCite] [Details]

Citations: Web of Science - 8


2012Minnerup J, Sutherland BA, Buchan AM, Kleinschnitz C, 'Neuroprotection for Stroke: Current Status and Future Perspectives', International journal of molecular sciences, 13, (9) pp. 11753-11772. ISSN 1422-0067 (2012) [Refereed Article]

DOI: 10.3390/ijms130911753 [eCite] [Details]

Citations: Scopus - 69Web of Science - 59


2012Sutherland BA, Minnerup J, Balami JS, Arba F, Buchan AM, et al., 'Neuroprotection for ischaemic stroke: Translation from the bench to the bedside', International Journal of Stroke, 7, (5) pp. 407-418. ISSN 1747-4930 (2012) [Refereed Article]

DOI: 10.1111/j.1747-4949.2012.00770.x [eCite] [Details]

Citations: Scopus - 121Web of Science - 113


2011Nair SM, Rahman RM, Clarkson AN, Sutherland BA, Taurin S, et al., 'Melatonin treatment following stroke induction modulates L-arginine metabolism', Journal of Pineal Research, 51, (3) pp. 313-23. ISSN 0742-3098 (2011) [Refereed Article]

DOI: 10.1111/j.1600-079X.2011.00891.x [eCite] [Details]

Citations: Scopus - 13Web of Science - 13


2011Rivers JR, Sutherland BA, Ashton JC, 'Characterization of a rat hypoxia-ischemia model where duration of hypoxia is determined by seizure activity', Journal of Neuroscience Methods, 197, (1) pp. 92-96. ISSN 0165-0270 (2011) [Refereed Article]

DOI: 10.1016/j.jneumeth.2011.02.002 [eCite] [Details]

Citations: Scopus - 7Web of Science - 6


2011Sutherland BA, Papadakis M, Chen R-L, Buchan AM, 'Cerebral blood flow alteration in neuroprotection following cerebral ischaemia', The Journal of physiology, 589, (17) pp. 4105-14. ISSN 0022-3751 (2011) [Refereed Article]

DOI: 10.1113/jphysiol.2011.209601 [eCite] [Details]

Citations: Scopus - 30Web of Science - 27


2011Sutherland BA, Shaw OM, Clarkson AN, Winburn IC, Errington AC, et al., 'Tin Protoporphyrin Provides Protection Following Cerebral Hypoxia-Ischemia: Involvement of Alternative Pathways', Journal of neuroscience research, 89 pp. 1284-1294. ISSN 0360-4012 (2011) [Refereed Article]

DOI: 10.1002/jnr.22661 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4


2010Harston GWJ, Sutherland BA, Kennedy J, Buchan AM, 'The contribution of L-arginine to the neurotoxicity of recombinant tissue plasminogen activator following cerebral ischemia: a review of rtPA neurotoxicity', Journal of Cerebral Blood Flow and Metabolism, 30, (11) pp. 1804-1816. ISSN 0271-678X (2010) [Refereed Article]

DOI: 10.1038/jcbfm.2010.149 [eCite] [Details]

Citations: Scopus - 27Web of Science - 29


2009Sutherland BA, Rahman RM, Clarkson AN, Shaw OM, Nair SM, et al., 'Cerebral heme oxygenase 1 and 2 spatial distribution is modulated following injury from hypoxia-ischemia and middle cerebral artery occlusion in rats', Neuroscience Research, 65, (4) pp. 326-334. ISSN 0168-0102 (2009) [Refereed Article]

DOI: 10.1016/j.neures.2009.08.007 [eCite] [Details]

Citations: Scopus - 20Web of Science - 19


2007Ashton JC, Rahman RM, Nair SM, Sutherland BA, Glass M, et al., 'Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain', Neuroscience letters, 412, (2) pp. 114-117. ISSN 0304-3940 (2007) [Refereed Article]

DOI: 10.1016/j.neulet.2006.10.053 [eCite] [Details]

Citations: Scopus - 93Web of Science - 82


2006Sutherland BA, Rahman RM, Appleton I, 'Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration', Journal of Nutritional Biochemistry, 17, (5) pp. 291 - 306. ISSN 0955-2863 (2006) [Refereed Article]

DOI: 10.1016/j.jnutbio.2005.10.005 [eCite] [Details]

Citations: Scopus - 199Web of Science - 162


2005Clarkson AN, Sutherland BA, Appleton I, 'The biology and pathology of hypoxia-ischemia: an update', Archivum immunologiae et therapiae experimentalis, 53, (3) pp. 213-225. ISSN 0004-069X (2005) [Refereed Article]

PMID: 15995582 [eCite] [Details]

Citations: Web of Science - 46


2005Sutherland BA, Shaw OM, Clarkson AN, Jackson DM, Sammut IA, et al., 'Neuroprotective effects of (-)-epigallocatechin gallate after hypoxia-ischemia-induced brain damage: novel mechanisms of action', The FASEB Journal, 19, (2) pp. 258-260. ISSN 1530-6860 (2005) [Refereed Article]

DOI: 10.1096/fj.04-2806fje [eCite] [Details]

Citations: Scopus - 103Web of Science - 85


Chapter in Book

(4 outputs)
2017Neuhaus AA, Sutherland B, Buchan AM, 'Targeting Pericytes and the Microcirculation for Ischemic Stroke Therapy', Neuroprotective Therapy for Stroke and Ischemic Disease, Springer International Publishing, PA Lapchak and JH Zhang (ed), Switzerland, pp. 537-556. ISBN 978-3-319-45345-3 (2017) [Research Book Chapter]

DOI: 10.1007/978-3-319-45345-3_22 [eCite] [Details]


2017Neuhaus AA, Sutherland BA, Buchan AM, 'Targeting Pericytes and the Microcirculation for Ischemic Stroke Therapy', Neuroprotective Therapy for Stroke and Ischemic Disease, Springer International Publishing, PA Lapchack and JH Zhang (ed), Switzerland, pp. 537-556. ISBN 978-3-319-45344-6 (2017) [Research Book Chapter]

DOI: 10.1007/978-3-319-45345-3_22 [eCite] [Details]


2016Hoyte LC, Sutherland BA, Buchan AM, 'Animal models of stroke', Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, J Stein (ed), United States, pp. 1-10. ISBN 978-0-12-809324-5 (2016) [Other Book Chapter]

DOI: 10.1016/B978-0-12-809324-5.02030-7 [eCite] [Details]


2014Sutherland BA, Rabie T, Buchan AM, 'Laser Doppler Flowmetry to Measure Changes in Cerebral Blood Flow', Cerebral Angiogenesis Methods and Protocols, Humana Press, R Milner (ed), United Kingdom, pp. 237-248. ISBN 978-1-4939-0320-7 (2014) [Research Book Chapter]

DOI: 10.1007/978-1-4939-0320-7_20 [eCite] [Details]

Citations: Scopus - 2


Conference Publication

(1 outputs)
2014Sutherland BA, 'Keynote speaker: pre-clinical research the potential therapeutic opportunities for various gases including oxygen', British Hyperbaric Association Annual Meeting, 7-8 November, 2014, Hull, United Kingdom (2014) [Keynote Presentation]

[eCite] [Details]

Other Public Output

(1 outputs)
2017Landowski LM, Sutherland BA, Eaton E, 'Science in the Pub, Brain edition: Neuropathy, Stroke and Alzheimer's Disease', Afternoons with Helen Shield, ABC Hobart radio, 5 July 2017 (2017) [Media Interview]

[eCite] [Details]

Co-authors: Landowski LM; Eaton E

Grants & Funding

Brad has previously held grants from the Medical Research Council, John Fell Fund, Wellcome Trust Institutional Strategic Support Fund and Medical Research Fund while working at the University of Oxford (UK).

Funding Summary

Number of grants


Total funding



Investigating ferroptosis as a novel mechanism of oligodendrocyte death. (2018)$30,000
This project aims to understand the mode of cell death induced by a stroke, and determine the capacity for already developed therapeutics to rescue these cells. By saving oligodendrocytes from death after stroke, we aim to reduce the lesion size, but also keep these critical cells in place to support nerve cell survival and function.
Brain Foundation ($30,000)
Administered By
University of Tasmania
Research Team
Cullen CL; Young Kaylene; Sutherland BA
Blood-brain barrier energy dysfunction: the unifying cause of fatigue (2017)$99,874
Fatigue can be much more than just a sense of tiredness. It is also a debilitating symptom of many diseases and disorders, hampering peoples ability to perform the simplest of daily activities. The underlying mechanism of fatigue is unknown. We hypothesise that fatigue is ultimately the result of reduced delivery of energy to the brain. We will assess how energy supply is altered in fatigued brain. A special diet (that supplies an alternative energy source for the brain) will be used to circumvent this energy deficit. We hope to establish how fatigue occurs and offer clues to a simple treatment strategy.
The Mason Foundation ($99,874)
Grant-Judith Jane Mason & Harold Stannett Williams
Administered By
University of Tasmania
Research Team
Howells DW; Sutherland BA; Landowski LM; Eaton ED; Allan S; Morten K
Paving the way for future stroke drug development: creating a reproducible, humanised model of stroke (2017 - 2019)$442,570
Stroke is a leading cause of death and chronic disability. Stroke therapeutics developed in animal models fail when translated into human clinical trials, due to flaws inherent in these models. We will break through this translational roadblock by using magnetic microparticles to induce an ischemic stroke that accurately represents human disease
Royal Hobart Hospital Research Foundation ($442,570)
Grant - Project Grant Funding
Administered By
University of Tasmania
Research Team
Landowski LM; Howells DW; Castley H; Sutherland BA; Kirkcaldie MTK
2017 - 2019
Squeezed to death by pericytes: a new target for ischaemic stroke treatment (2017)$20,000
University of Tasmania ($20,000)
Grant- Research Enhancement Program
Administered By
University of Tasmania
Research Team
Sutherland BA

Research Supervision

Brad has co-supervised two PhD students and one Masters student while working at the University Oxford (UK). Brad is currently available to take on supervision of Higher Degree Research Students in the Faculty of Health.




PhDPericyte Regulation of Blood Flow in the Brain and its Dysfunction Following Stroke2017
PhDEpigenetic Imprinting and the Burgeoning of Obesity. the importance of a balanced nutrition during gestation2017