Profiles

Brad Sutherland

UTAS Home Dr Brad Sutherland

Brad Sutherland

Senior Research Fellow

Room MS2, Level 4, 440-10, Medical Sciences Precinct, Hobart CBD Campuses

+61 3 6226 7634 (phone)

Brad.Sutherland@utas.edu.au

Dr Brad Sutherland is a Senior Research Fellow in the School of Medicine in the Faculty of Health. His main research interests are in understanding how blood flow is regulated in the brain, identifying mechanisms of brain injury following stroke, and discovering novel therapeutic targets. He also teaches Pharmacology and Neuroscience into a number of units as part of the BPharm and BMedRes degrees.

Biography

Brad completed his PhD at the University of Otago (Dunedin, New Zealand) where he investigated the activation of inflammatory pathways in the brain after stroke. After a small stint as a Teaching Fellow in Pharmacology & Toxicology (University of Otago), he took up a Post-doctoral Research Fellowship with the Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford (Oxford, UK). During his time in Oxford, he formed an interest in the regulation of blood flow in the brain in health and disease. This led to studies investigating the interaction between brain tissue and the blood vessels, the signalling mechanisms that controlled energy delivery to the brain, and how these were disrupted in conditions such as stroke.

In mid-2016, Brad arrived at the University of Tasmania to continue his research into blood flow and brain injury following stroke. He continues to use a wide range of in vitro and in vivo models of stroke to assess mechanisms of injury to the brain and its vasculature.

Career summary

Qualifications

Degree

Thesis title

University

Country

Date

PhD

Heme oxygenase and the use of tin protoporphyrin in hypoxia-ischaemia-induced brain damage: mechanisms of action

University of Otago

New Zealand

2009

BSc (1st Class Hons)

The neuroprotective effect of epigallocatechin gallate following hypoxia-ischaemia-induced brain damage and its mechanisms of action

University of Otago

New Zealand

2004

Memberships

Professional practice

  • The International Society for Cerebral Blood Flow and Metabolism (ISCBFM)
  • Australasian Neuroscience Society (ANS)

Teaching

Pharmacology, Neuroscience, Stroke, Biochemistry, Physiology, Neuropathology

Teaching expertise

Brad’s expertise is in the teaching of undergraduate Pharmacology and Neuroscience. He also has experience in teaching Biochemistry, Physiology and Neuropathology and coordinating Pharmacology units. He has also supervised both undergraduate and postgraduate research projects.

Teaching responsibility

Brad regularly contributes to the teaching of:

  • Pharmacology (CSA230, CSA232, CSA234)
  • Pharmacology (CSA231, CSA233, CSA235)
  • Neuroscience B (CHP312)
  • Research Project in Health and Disease (CBA344)

View more on Dr Brad Sutherland in WARP

Expertise

Over many years, Brad has developed skills in a range of techniques to investigate blood flow in the brain, and model stroke. Specifically, he has experience with multiple stroke models including intraluminal filament middle cerebral artery occlusion (MCAO) model and hypoxia-ischaemia model. He also uses in vitro models of stroke on primary cells or cell lines in culture by exposing cells to oxygen and glucose deprivation. He employs a range of techniques including light, epifluorescence, confocal and two-photon microscopy, immunohistochemistry, histology, molecular biology, and animal behaviour. He also has experience with animal MRI. These techniques can be utilised to investigate the biological basis of a range of neurological disorders.

Research Themes

Brad’s research aligns to the University’s research theme of Better Health. His research interests include understanding how blood flow is regulated in the brain, identifying mechanisms of brain injury following stroke, and discovering novel therapeutic targets that can protect the brain after stroke. He utilises a wide range of in vitro and in vivo models to assess brain function and brain injury after stroke.

Blood flow in the brain is controlled by the neurovascular unit, which is a complex interplay of cells that communicate in order to increase blood - and therefore energy – supply in areas where brain activity is occurring. This is a tightly coupled process that uses complex paracrine signalling mechanisms and is prone to injury when an insult occurs such as stroke. Brad is currently investigating the role of multiple cell types in this “neurovascular coupling” process and the mechanisms by which neurovascular dysfunction occurs during stroke.

Recently, Brad has developed an interest in the microcirculation, specifically a cell type called pericytes which exclusively reside on capillaries. These cells are involved in many brain processes including regulating blood flow in the brain and maintenance of the blood-brain barrier and may contribute to injury and repair following stroke. Brad’s ongoing studies are examining mechanisms of pericyte dysfunction following stroke.

Collaboration

Brad is actively involved in a number of collaborations. Locally, Brad works closely with Prof David Howells, an experienced stroke researcher, within the School of Medicine. Brad continues to collaborate with Prof Alastair Buchan, Assoc Prof James Kennedy, Assoc Prof Nicola Sibson, Assoc Prof Gabriele De Luca and Dr Karl Morten from the University of Oxford (UK) on a range of stroke and metabolism-related projects. He also collaborates with Assoc Prof Kostas Vekrellis (Bioacademy of Athens, Greece) on novel neuroprotective pathways. He has also collaborated on blood flow-related projects with Prof David Attwell (University College London, UK), Prof Brian MacVicar (University of British Columbia, Canada), Prof Martin Lauritzen (University of Copenhagen, Denmark), Dr Clare Howarth (University of Sheffield, UK), Dr Chris Martin (University of Sheffield, UK) and Dr Catherine Hall (University of Sussex, UK).

Fields of Research

  • Central Nervous System (110903)
  • Cellular Nervous System (110902)
  • Signal Transduction (060111)
  • Systems Physiology (111603)
  • Cardiology (incl. Cardiovascular Diseases) (110201)
  • Cell Physiology (111601)
  • Sensory Systems (110906)
  • Basic Pharmacology (111501)
  • Foetal Development and Medicine (111401)
  • Obstetrics and Gynaecology (111402)
  • Exercise Physiology (110602)

Research Objectives

  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Cardiovascular System and Diseases (920103)
  • Nervous System and Disorders (920111)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Expanding Knowledge in the Biological Sciences (970106)
  • Diabetes (920104)
  • Reproductive System and Disorders (920114)
  • Child Health (920501)
  • Hearing, Vision, Speech and Their Disorders (920107)
  • Skin and Related Disorders (920117)
  • Endocrine Organs and Diseases (excl. Diabetes) (920106)

Publications

Dr Sutherland publishes regularly in high impact journals. He has more than 30 peer-reviewed papers including papers in Nature, Brain and Journal of Cerebral Blood Flow and Metabolism. He reviews grant applications for a number of granting bodies as well papers for a wide range of neuroscience journals.

Total publications

39

Journal Article

(32 outputs)
YearCitationAltmetrics
2017Hadley G, Neuhaus AA, Couch Y, Beard DJ, Adriaanse BA, et al., 'The role of the endoplasmic reticulum stress response following cerebral ischemia', International journal of stroke ISSN 1747-4930 (2017) [Refereed Article]

DOI: 10.1177/1747493017724584 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2017Howarth C, Sutherland BA, Choi HB, Martin C, Lind BL, et al., 'A critical role for astrocytes in hypercapnic vasodilation in brain', Journal of Neuroscience, 37, (9) pp. 2403-2414. ISSN 0270-6474 (2017) [Refereed Article]

DOI: 10.1523/JNEUROSCI.0005-16.2016 [eCite] [Details]

Citations: Scopus - 7Web of Science - 9

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2017Percie du Sert N, Alfieri A, Allan SM, Carswell HV, Deuchar GA, et al., 'The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)', Journal of Cerebral Blood Flow and Metabolism, 37, (11) pp. 3488-3517. ISSN 0271-678X (2017) [Refereed Article]

DOI: 10.1177/0271678X17709185 [eCite] [Details]

Citations: Scopus - 9Web of Science - 5

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2017Sutherland BA, Fordsmann JC, Martin C, Neuhaus AA, Witgen BM, et al., 'Multi-modal assessment of neurovascular coupling during cerebral ischaemia and reperfusion using remote middle cerebral artery occlusion', Journal of Cerebral Blood Flow and Metabolism, 37, (7) pp. 2494-2508. ISSN 1559-7016 (2017) [Refereed Article]

DOI: 10.1177/0271678X16669512 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2017Neuhaus AA, Couch Y, Sutherland BA, Buchan AM, 'Novel method to study pericyte contractility and responses to ischaemia in vitro using electrical impedance', Journal of Cerebral Blood Flow and Metabolism, 37, (6) pp. 2013-2024. ISSN 0271-678X (2017) [Refereed Article]

DOI: 10.1177/0271678X16659495 [eCite] [Details]

Citations: Scopus - 7Web of Science - 6

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2016Sutherland BA, Neuhaus AA, Couch Y, Balami JS, DeLuca GC, et al., 'The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke', Journal of cerebral blood flow and metabolism, 36, (2) pp. 363-369. ISSN 0271-678X (2016) [Refereed Article]

DOI: 10.1177/0271678X15606722 [eCite] [Details]

Citations: Scopus - 14Web of Science - 14

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2016Kapoor M, Clarkson AN, Sutherland BA, Appleton I, 'The role of antioxidants in models of inflammation: emphasis on L-arginine and arachidonic acid metabolism', Inflammopharmacology, 12, (5-6) pp. 505-19. ISSN 0925-4692 (2016) [Refereed Article]

DOI: 10.1163/156856005774382797 [eCite] [Details]

Citations: Scopus - 15

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2015Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM, 'Reply: Intravenous thrombolysis for ischaemic strokes: a call for reappraisal', Brain, 138, (4) pp. e342. ISSN 0006-8950 (2015) [Letter or Note in Journal]

DOI: 10.1093/brain/awu283 [eCite] [Details]

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2015Buchan AM, Karbalai HG, Sutherland BA, 'The future of stroke therapy must not be mired by past arguments', The Lancet, 386, (9994) pp. 654. ISSN 0140-6736 (2015) [Letter or Note in Journal]

[eCite] [Details]

2015Redzic ZB, Rabie T, Sutherland BA, Buchan AM, 'Differential effects of paracrine factors on the survival of cells of the neurovascular unit during oxygen glucose deprivation', International journal of stroke, 10, (3) pp. 407-414. ISSN 1747-4930 (2015) [Refereed Article]

DOI: 10.1111/ijs.12197 [eCite] [Details]

Citations: Scopus - 10Web of Science - 7

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2015Balami JS, Sutherland BA, Edmunds LD, Grunwald IQ, Neuhaus AA, et al., 'A systematic review and meta-analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke', International journal of stroke, 10, (8) pp. 1168-1178. ISSN 1747-4930 (2015) [Refereed Article]

DOI: 10.1111/ijs.12618 [eCite] [Details]

Citations: Scopus - 38Web of Science - 39

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2014Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM, 'Reply: Thrombolysis in acute ischaemic stroke', Brain, 137, (1) pp. e282. ISSN 0006-8950 (2014) [Letter or Note in Journal]

DOI: 10.1093/brain/awu066 [eCite] [Details]

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2014Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, et al., 'Capillary pericytes regulate cerebral blood flow in health and disease', Nature, 508, (7494) pp. 55-60. ISSN 0028-0836 (2014) [Refereed Article]

DOI: 10.1038/nature13165 [eCite] [Details]

Citations: Scopus - 409Web of Science - 412

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2014Neuhaus AA, Rabie T, Sutherland BA, Papadakis M, Hadley G, et al., 'Importance of preclinical research in the development of neuroprotective strategies for ischemic stroke', JAMA neurology, 71, (5) pp. 634-639. ISSN 2168-6149 (2014) [Refereed Article]

DOI: 10.1001/jamaneurol.2013.6299 [eCite] [Details]

Citations: Scopus - 26Web of Science - 24

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2014Sutherland BA, Buchan AM, 'The life of Bo K. Siesjo, MD, PhD, 1930-2013', International Journal of Stroke, 9, (1) pp. 2-4. ISSN 1747-4930 (2014) [Letter or Note in Journal]

DOI: 10.1111/ijs.12237 [eCite] [Details]

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2013Balami JS, Chen R, Sutherland BA, Buchan AM, 'Thrombolytic Agents for Acute Ischaemic Stroke Treatment: The Past, Present and Future', CNS & neurological disorders drug targets, 12, (2) pp. 145-154. ISSN 1871-5273 (2013) [Refereed Article]

DOI: 10.2174/18715273113129990057 [eCite] [Details]

Citations: Scopus - 17Web of Science - 10

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2013Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM, 'The exact science of stroke thrombolysis and the quiet art of patient selection', Brain, 136, (Pt 12) pp. 3528-3553. ISSN 0006-8950 (2013) [Refereed Article]

DOI: 10.1093/brain/awt201 [eCite] [Details]

Citations: Scopus - 33Web of Science - 32

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2013Balami JS, Sutherland BA, Buchan AM, 'Complications Associated with Recombinant Tissue Plasminogen Activator Therapy for Acute Ischaemic Stroke', CNS & neurological disorders drug targets, 12, (2) pp. 155-169. ISSN 1871-5273 (2013) [Refereed Article]

DOI: 10.2174/18715273112119990050 [eCite] [Details]

Citations: Scopus - 26Web of Science - 23

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2013Sutherland BA, Buchan AM, 'Alteplase treatment does not increase brain injury after mechanical middle cerebral artery occlusion in the rat', Journal of Cerebral Blood Flow and Metabolism, 33, (11) pp. e1-7. ISSN 0271-678X (2013) [Refereed Article]

DOI: 10.1038/jcbfm.2013.148 [eCite] [Details]

Citations: Scopus - 11

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2013Sutherland BA, Harrison JC, Nair SM, Sammut IA, 'Inhalation gases or gaseous mediators as neuroprotectants for cerebral ischaemia', Current drug targets, 14, (1) pp. 56-73. ISSN 1389-4501 (2013) [Refereed Article]

DOI: 10.2174/1389450111314010007 [eCite] [Details]

Citations: Web of Science - 9

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2012Minnerup J, Sutherland BA, Buchan AM, Kleinschnitz C, 'Neuroprotection for Stroke: Current Status and Future Perspectives', International journal of molecular sciences, 13, (9) pp. 11753-11772. ISSN 1422-0067 (2012) [Refereed Article]

DOI: 10.3390/ijms130911753 [eCite] [Details]

Citations: Scopus - 85Web of Science - 77

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2012Sutherland BA, Minnerup J, Balami JS, Arba F, Buchan AM, et al., 'Neuroprotection for ischaemic stroke: Translation from the bench to the bedside', International Journal of Stroke, 7, (5) pp. 407-418. ISSN 1747-4930 (2012) [Refereed Article]

DOI: 10.1111/j.1747-4949.2012.00770.x [eCite] [Details]

Citations: Scopus - 131Web of Science - 123

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2011Nair SM, Rahman RM, Clarkson AN, Sutherland BA, Taurin S, et al., 'Melatonin treatment following stroke induction modulates L-arginine metabolism', Journal of Pineal Research, 51, (3) pp. 313-23. ISSN 0742-3098 (2011) [Refereed Article]

DOI: 10.1111/j.1600-079X.2011.00891.x [eCite] [Details]

Citations: Scopus - 15Web of Science - 14

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2011Rivers JR, Sutherland BA, Ashton JC, 'Characterization of a rat hypoxia-ischemia model where duration of hypoxia is determined by seizure activity', Journal of Neuroscience Methods, 197, (1) pp. 92-96. ISSN 0165-0270 (2011) [Refereed Article]

DOI: 10.1016/j.jneumeth.2011.02.002 [eCite] [Details]

Citations: Scopus - 7Web of Science - 6

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2011Sutherland BA, Papadakis M, Chen R-L, Buchan AM, 'Cerebral blood flow alteration in neuroprotection following cerebral ischaemia', The Journal of physiology, 589, (17) pp. 4105-14. ISSN 0022-3751 (2011) [Refereed Article]

DOI: 10.1113/jphysiol.2011.209601 [eCite] [Details]

Citations: Scopus - 31Web of Science - 29

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2011Sutherland BA, Shaw OM, Clarkson AN, Winburn IC, Errington AC, et al., 'Tin Protoporphyrin Provides Protection Following Cerebral Hypoxia-Ischemia: Involvement of Alternative Pathways', Journal of neuroscience research, 89 pp. 1284-1294. ISSN 0360-4012 (2011) [Refereed Article]

DOI: 10.1002/jnr.22661 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

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2010Harston GWJ, Sutherland BA, Kennedy J, Buchan AM, 'The contribution of L-arginine to the neurotoxicity of recombinant tissue plasminogen activator following cerebral ischemia: a review of rtPA neurotoxicity', Journal of Cerebral Blood Flow and Metabolism, 30, (11) pp. 1804-1816. ISSN 0271-678X (2010) [Refereed Article]

DOI: 10.1038/jcbfm.2010.149 [eCite] [Details]

Citations: Scopus - 31Web of Science - 33

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2009Sutherland BA, Rahman RM, Clarkson AN, Shaw OM, Nair SM, et al., 'Cerebral heme oxygenase 1 and 2 spatial distribution is modulated following injury from hypoxia-ischemia and middle cerebral artery occlusion in rats', Neuroscience Research, 65, (4) pp. 326-334. ISSN 0168-0102 (2009) [Refereed Article]

DOI: 10.1016/j.neures.2009.08.007 [eCite] [Details]

Citations: Scopus - 21Web of Science - 20

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2007Ashton JC, Rahman RM, Nair SM, Sutherland BA, Glass M, et al., 'Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain', Neuroscience letters, 412, (2) pp. 114-117. ISSN 0304-3940 (2007) [Refereed Article]

DOI: 10.1016/j.neulet.2006.10.053 [eCite] [Details]

Citations: Scopus - 96Web of Science - 87

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2006Sutherland BA, Rahman RM, Appleton I, 'Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration', Journal of Nutritional Biochemistry, 17, (5) pp. 291 - 306. ISSN 0955-2863 (2006) [Refereed Article]

DOI: 10.1016/j.jnutbio.2005.10.005 [eCite] [Details]

Citations: Scopus - 205Web of Science - 166

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2005Clarkson AN, Sutherland BA, Appleton I, 'The biology and pathology of hypoxia-ischemia: an update', Archivum immunologiae et therapiae experimentalis, 53, (3) pp. 213-225. ISSN 0004-069X (2005) [Refereed Article]

PMID: 15995582 [eCite] [Details]

Citations: Web of Science - 47

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2005Sutherland BA, Shaw OM, Clarkson AN, Jackson DM, Sammut IA, et al., 'Neuroprotective effects of (-)-epigallocatechin gallate after hypoxia-ischemia-induced brain damage: novel mechanisms of action', The FASEB Journal, 19, (2) pp. 258-260. ISSN 1530-6860 (2005) [Refereed Article]

DOI: 10.1096/fj.04-2806fje [eCite] [Details]

Citations: Scopus - 109Web of Science - 91

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Chapter in Book

(4 outputs)
YearCitationAltmetrics
2017Neuhaus AA, Sutherland B, Buchan AM, 'Targeting Pericytes and the Microcirculation for Ischemic Stroke Therapy', Neuroprotective Therapy for Stroke and Ischemic Disease, Springer International Publishing, PA Lapchak and JH Zhang (ed), Switzerland, pp. 537-556. ISBN 978-3-319-45345-3 (2017) [Research Book Chapter]

DOI: 10.1007/978-3-319-45345-3_22 [eCite] [Details]

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2017Neuhaus AA, Sutherland BA, Buchan AM, 'Targeting Pericytes and the Microcirculation for Ischemic Stroke Therapy', Neuroprotective Therapy for Stroke and Ischemic Disease, Springer International Publishing, PA Lapchack and JH Zhang (ed), Switzerland, pp. 537-556. ISBN 978-3-319-45344-6 (2017) [Research Book Chapter]

DOI: 10.1007/978-3-319-45345-3_22 [eCite] [Details]

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2016Hoyte LC, Sutherland BA, Buchan AM, 'Animal models of stroke', Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, J Stein (ed), United States, pp. 1-10. ISBN 978-0-12-809324-5 (2016) [Other Book Chapter]

DOI: 10.1016/B978-0-12-809324-5.02030-7 [eCite] [Details]

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2014Sutherland BA, Rabie T, Buchan AM, 'Laser Doppler Flowmetry to Measure Changes in Cerebral Blood Flow', Cerebral Angiogenesis Methods and Protocols, Humana Press, R Milner (ed), United Kingdom, pp. 237-248. ISBN 978-1-4939-0320-7 (2014) [Research Book Chapter]

DOI: 10.1007/978-1-4939-0320-7_20 [eCite] [Details]

Citations: Scopus - 5

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Conference Publication

(1 outputs)
YearCitationAltmetrics
2014Sutherland BA, 'Keynote speaker: pre-clinical research the potential therapeutic opportunities for various gases including oxygen', British Hyperbaric Association Annual Meeting, 7-8 November, 2014, Hull, United Kingdom (2014) [Keynote Presentation]

[eCite] [Details]

Other Public Output

(2 outputs)
YearCitationAltmetrics
2017Landowski LM, Sutherland BA, Eaton E, 'Science in the Pub, Brain edition: Neuropathy, Stroke and Alzheimer's Disease', Afternoons with Helen Shield, ABC Hobart radio, 5 July 2017 (2017) [Media Interview]

[eCite] [Details]

Co-authors: Landowski LM; Eaton E

2017Sutherland BA, 'Interview with Helen Shield', ABC Nightlife with Helen Shield National Broadcast, 8 February 2017 (2017) [Media Interview]

[eCite] [Details]

Grants & Funding

Brad has previously held grants from the Medical Research Council, John Fell Fund, Wellcome Trust Institutional Strategic Support Fund and Medical Research Fund while working at the University of Oxford (UK).

Funding Summary

Number of grants

10

Total funding

$1,545,065

Projects

Investigating ferroptosis as a novel mechanism of oligodendrocyte death. (2018)$30,000
Description
This project aims to understand the mode of cell death induced by a stroke, and determine the capacity for already developed therapeutics to rescue these cells. By saving oligodendrocytes from death after stroke, we aim to reduce the lesion size, but also keep these critical cells in place to support nerve cell survival and function.
Funding
Brain Foundation ($30,000)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Cullen CL; Young Kaylene; Sutherland BA
Year
2018
In pursuit of an innovative experimental model of vascular dementia-a pilot study (2018)$10,000
Description
This collaboration will be between imaging neuroscientists based in the Wicking DementiaResearch and Education Centre (Canty, Bennett) and a cerebral vascular biologist based inthe School of Medicine (Sutherland). This work will take two different areas of biologicalresearch, our blood vessels and our brains, and investigate how reduced blood flow caninfluence neurons within our brains after an ischemic event typical of vascular dementia.This collaboration will run across two divisions of the College of Health and Medicine: theSchool of Medicine and the Wicking Dementia Centre and include staff at different levels(D/C/B). This collaboration aligns with the University subtheme of complex disease, underthe umbrella of Better Health - investigating the complexity of mixed dementia and linking itwith cardiovascular health. Dementia is a recognised flagship of the College of Health andMedicine, and this project aims to initiate a new area of research in vascular dementia,capitalising on existing researcher strengths. Alison Canty and Brad Sutherland are leaders intheir respective fields of expertise, and seek to work together on this innovative project toestablish a new line of enquiry to determine the origins of the pathology of vasculardementia. If funded, and if successful, we would aim to recruit a HDR student to continuethis work, providing a valuable training opportunity
Funding
University of Tasmania ($10,000)
Scheme
Grant- Research Enhancement Program
Administered By
University of Tasmania
Research Team
Canty A; Sutherland BA; Bennett WR
Year
2018
The pathological effects of Alzheimer's disease on axons (2018 - 2020)$90,000
Description
Proposed PhD project investigating the role of amyoloid upon axonal dystrophies in the progression of Alzheimers disease
Funding
Dementia Australia Research Foundation Ltd ($90,000)
Scheme
Grant-Scholarship
Administered By
University of Tasmania
Research Team
Young Kaylene; Blizzard C; Cullen CL; Sutherland BA
Period
2018 - 2020
Can anti-diabetic agents improve blood flow and outcome following stroke in type 2 diabetes? (2018)$24,912
Description
People with type 2 diabetes are four times more likely to have a stroke. Interestingly, common anti-diabetic drugs seem to improve patient outcomes following a stroke. This project will determine whether anti-diabetic drugs improve brain blood flow dynamics during and after stroke to reduce stroke severity in an animal model of type 2 diabetes.
Funding
Royal Hobart Hospital Research Foundation ($24,912)
Scheme
Grant-Minor Project
Administered By
University of Tasmania
Research Team
Premilovac D; Sutherland BA; Burgess JR; Howells DW; Foa LC; Keske MAV
Year
2018
Pericyte dysfunction limiting energy supply in Alzheimer's disease (2018 - 2021)$717,709
Description
Pericytes are contractile cells exclusively residing on the basement membrane of capillaries. These cells have been shown to control cerebralblood flow and energy supply, maintain the blood-brain barrier (BBB) and mediate beta amyloid clearance. An emerging pathologicalmechanism of Alzheimers disease (AD) is the development of vascular dysfunction leading to chronic hypoperfusion, disruption of the BBBand altered beta amyloid clearance. These symptoms are all, in part, controlled by pericytes. Therefore, the degeneration of pericytes may becritical to the development of AD and could represent a novel cellular target for AD therapy. I will utilise my strong background in pericyte andneurovascular biology to:1) Establish a link between pericyte loss and human AD pathology. I will use human post-mortem brains and immunohistochemicaltechniques to assess pericyte degradation and its association with cognitive loss as well as amyloid, tau and vascular pathology.2) Follow changes in pericyte number, coverage and function alongside the development of AD. I will use NG2-DsRed mice that havefluorescent pericytes crossed with an animal model of AD to observe how pericytes change by assessing BBB function and capillary blood flowas AD pathology develops.3) Modulate blood flow and pericyte function directly in NG2-DsRed mice to associate pericyte dysfunction with changes in cognitivebehaviour and AD progression.4) Determine the mechanism of pericyte loss in AD using human pericyte cultures and identify novel compounds that could prevent pericyte degradation and cognitive decline.This research will provide an understanding of the importance of pericyte degeneration to AD pathology and whether pericytes represent a viable target on which further pre-clinical development of pericyte-targeting drugs for AD can begin.
Funding
National Health & Medical Research Council ($717,709)
Scheme
Fellowship - Boosting Dementia Research Leadership
Administered By
University of Tasmania
Research Team
Sutherland BA
Period
2018 - 2021
Grant Reference
APP1137776
The Peri-Peri project: the role of pericytes in placental function and perinatal outcome (2018)$10,000
Description
This project will assess how pericytes, a specific cell that may control blood flow in placenta, could contribute to restricted growth of babies during pregnancy.
Funding
Royal Hobart Hospital Research Foundation ($10,000)
Scheme
Grant-Starter
Administered By
University of Tasmania
Research Team
Sutherland BA; Dargaville PA; Edwards L
Year
2018
Blood vessels squeezed to death by pericytes: a new therapeutic target for ischaemic stroke (2018 - 2019)$100,000
Description
This project will assess how pericytes, a specific cell that may control blood flow in the brain, are affected by stroke and will identify mechanisms that could be targeted as a treatment strategy for stroke.
Funding
Rebecca L Cooper Medical Research Foundation ($100,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Sutherland BA
Period
2018 - 2019
Blood-brain barrier energy dysfunction: the unifying cause of fatigue (2017)$99,874
Description
Fatigue can be much more than just a sense of tiredness. It is also a debilitating symptom of many diseases and disorders, hampering peoples ability to perform the simplest of daily activities. The underlying mechanism of fatigue is unknown. We hypothesise that fatigue is ultimately the result of reduced delivery of energy to the brain. We will assess how energy supply is altered in fatigued brain. A special diet (that supplies an alternative energy source for the brain) will be used to circumvent this energy deficit. We hope to establish how fatigue occurs and offer clues to a simple treatment strategy.
Funding
The Mason Foundation ($99,874)
Scheme
Grant-Judith Jane Mason & Harold Stannett Williams
Administered By
University of Tasmania
Research Team
Howells DW; Sutherland BA; Landowski LM; Eaton ED; Allan S; Morten K
Year
2017
Paving the way for future stroke drug development: creating a reproducible, humanised model of stroke (2017 - 2019)$442,570
Description
Stroke is a leading cause of death and chronic disability. Stroke therapeutics developed in animal models fail when translated into human clinical trials, due to flaws inherent in these models. We will break through this translational roadblock by using magnetic microparticles to induce an ischemic stroke that accurately represents human disease
Funding
Royal Hobart Hospital Research Foundation ($442,570)
Scheme
Grant - Project Grant Funding
Administered By
University of Tasmania
Research Team
Landowski LM; Howells DW; Castley H; Sutherland BA; Kirkcaldie MTK
Period
2017 - 2019
Squeezed to death by pericytes: a new target for ischaemic stroke treatment (2017)$20,000
Funding
University of Tasmania ($20,000)
Scheme
Grant- Research Enhancement Program
Administered By
University of Tasmania
Research Team
Sutherland BA
Year
2017

Research Supervision

Brad has co-supervised two PhD students and one Masters student while working at the University Oxford (UK). Brad is currently available to take on supervision of Higher Degree Research Students in the Faculty of Health.

Current

5

Current

DegreeTitleCommenced
PhDPericyte Regulation of Blood Flow in the Brain and its Dysfunction Following Stroke2017
PhDDeveloping Asperuloside, a Newly Compund Important for Food Intake Reduction in Obesity2017
PhDPericyte Dysfunction Limiting Energy Supply in Alzheimer's Disease2018
PhDSurgical and Anaesthetic Comorbidity in Animal Models of Stroke: A veil over effective drug development2018
PhDHow Do Myelinating Cells Alter Brain Circuits to Facilitate Learning?2018