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Brad Sutherland

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Brad Sutherland

Senior Research Fellow

Room MS2, Level 4, 440-10, Medical Sciences Precinct, Hobart CBD Campuses

+61 3 6226 7634 (phone)

Brad.Sutherland@utas.edu.au

Dr Brad Sutherland is a Senior Research Fellow in the School of Medicine in the Faculty of Health. His main research interests are in understanding how blood flow is regulated in the brain, identifying mechanisms of brain injury following stroke, and discovering novel therapeutic targets. He also teaches Pharmacology and Neuroscience into a number of units as part of the BPharm and BMedRes degrees.

Career summary

Qualifications

Degree

Thesis title

University

Country

Date

PhD

Heme oxygenase and the use of tin protoporphyrin in hypoxia-ischaemia-induced brain damage: mechanisms of action

University of Otago

New Zealand

2009

BSc (1st Class Hons)

The neuroprotective effect of epigallocatechin gallate following hypoxia-ischaemia-induced brain damage and its mechanisms of action

University of Otago

New Zealand

2004

Biography

Brad completed his PhD at the University of Otago (Dunedin, New Zealand) where he investigated the activation of inflammatory pathways in the brain after stroke. After a small stint as a Teaching Fellow in Pharmacology & Toxicology (University of Otago), he took up a Post-doctoral Research Fellowship with the Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford (Oxford, UK). During his time in Oxford, he formed an interest in the regulation of blood flow in the brain in health and disease. This led to studies investigating the interaction between brain tissue and the blood vessels, the signalling mechanisms that controlled energy delivery to the brain, and how these were disrupted in conditions such as stroke.

In mid-2016, Brad arrived at the University of Tasmania to continue his research into blood flow and brain injury following stroke. He continues to use a wide range of in vitro and in vivo models of stroke to assess mechanisms of injury to the brain and its vasculature.

Research Themes

Brad’s research aligns to the University’s research theme of Better Health. His research interests include understanding how blood flow is regulated in the brain, identifying mechanisms of brain injury following stroke, and discovering novel therapeutic targets that can protect the brain after stroke. He utilises a wide range of in vitro and in vivo models to assess brain function and brain injury after stroke.

Blood flow in the brain is controlled by the neurovascular unit, which is a complex interplay of cells that communicate in order to increase blood - and therefore energy – supply in areas where brain activity is occurring. This is a tightly coupled process that uses complex paracrine signalling mechanisms and is prone to injury when an insult occurs such as stroke. Brad is currently investigating the role of multiple cell types in this “neurovascular coupling” process and the mechanisms by which neurovascular dysfunction occurs during stroke.

Recently, Brad has developed an interest in the microcirculation, specifically a cell type called pericytes which exclusively reside on capillaries. These cells are involved in many brain processes including regulating blood flow in the brain and maintenance of the blood-brain barrier and may contribute to injury and repair following stroke. Brad’s ongoing studies are examining mechanisms of pericyte dysfunction following stroke.

Memberships

Professional practice

  • The International Society for Cerebral Blood Flow and Metabolism (ISCBFM)
  • Australasian Neuroscience Society (ANS)

Teaching

Pharmacology, Neuroscience, Stroke, Biochemistry, Physiology, Neuropathology

Teaching expertise

Brad’s expertise is in the teaching of undergraduate Pharmacology and Neuroscience. He also has experience in teaching Biochemistry, Physiology and Neuropathology and coordinating Pharmacology units. He has also supervised both undergraduate and postgraduate research projects.

Teaching responsibility

Brad regularly contributes to the teaching of:

  • Pharmacology (CSA230, CSA232, CSA234)
  • Pharmacology (CSA231, CSA233, CSA235)
  • Neuroscience B (CHP312)
  • Research Project in Health and Disease (CBA344)

View more on Dr Brad Sutherland in WARP

Expertise

Over many years, Brad has developed skills in a range of techniques to investigate blood flow in the brain, and model stroke. Specifically, he has experience with multiple stroke models including intraluminal filament middle cerebral artery occlusion (MCAO) model and hypoxia-ischaemia model. He also uses in vitro models of stroke on primary cells or cell lines in culture by exposing cells to oxygen and glucose deprivation. He employs a range of techniques including light, epifluorescence, confocal and two-photon microscopy, immunohistochemistry, histology, molecular biology, and animal behaviour. He also has experience with animal MRI. These techniques can be utilised to investigate the biological basis of a range of neurological disorders.

Collaboration

Brad is actively involved in a number of collaborations. Locally, Brad works closely with Prof David Howells, an experienced stroke researcher, within the School of Medicine. Brad continues to collaborate with Prof Alastair Buchan, Assoc Prof James Kennedy, Assoc Prof Nicola Sibson, Assoc Prof Gabriele De Luca and Dr Karl Morten from the University of Oxford (UK) on a range of stroke and metabolism-related projects. He also collaborates with Assoc Prof Kostas Vekrellis (Bioacademy of Athens, Greece) on novel neuroprotective pathways. He has also collaborated on blood flow-related projects with Prof David Attwell (University College London, UK), Prof Brian MacVicar (University of British Columbia, Canada), Prof Martin Lauritzen (University of Copenhagen, Denmark), Dr Clare Howarth (University of Sheffield, UK), Dr Chris Martin (University of Sheffield, UK) and Dr Catherine Hall (University of Sussex, UK).

Fields of Research

  • Central Nervous System (110903)
  • Cell Physiology (111601)
  • Systems Physiology (111603)
  • Foetal Development and Medicine (111401)
  • Obstetrics and Gynaecology (111402)
  • Sensory Systems (110906)
  • Basic Pharmacology (111501)
  • Cardiology (incl. Cardiovascular Diseases) (110201)

Research Objectives

  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Reproductive System and Disorders (920114)
  • Child Health (920501)
  • Diabetes (920104)
  • Cardiovascular System and Diseases (920103)
  • Hearing, Vision, Speech and Their Disorders (920107)
  • Neurodegenerative Disorders Related to Ageing (920112)

Publications

Dr Sutherland publishes regularly in high impact journals. He has more than 30 peer-reviewed papers including papers in Nature, Brain and Journal of Cerebral Blood Flow and Metabolism. He reviews grant applications for a number of granting bodies as well papers for a wide range of neuroscience journals.

Total publications

32

Journal Article

(29 outputs)
YearCitationAltmetrics
2016Kapoor M, Clarkson AN, Sutherland BA, Appleton I, 'The role of antioxidants in models of inflammation: emphasis on L-arginine and arachidonic acid metabolism', Inflammopharmacology, 12, (5-6) pp. 505-19. ISSN 0925-4692 (2016) [Refereed Article]

DOI: 10.1163/156856005774382797 [eCite] [Details]

Citations: Scopus - 13

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2016Neuhaus AA, Couch Y, Sutherland BA, Buchan AM, 'Novel method to study pericyte contractility and responses to ischaemia in vitro using electrical impedance', Journal of cerebral blood flow and metabolism pp. 1-12. ISSN 0271-678X (2016) [Refereed Article]

DOI: 10.1177/0271678X16659495 [eCite] [Details]

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2016Sutherland BA, Neuhaus AA, Couch Y, Balami JS, DeLuca GC, et al., 'The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke', Journal of cerebral blood flow and metabolism, 36, (2) pp. 363-369. ISSN 0271-678X (2016) [Refereed Article]

DOI: 10.1177/0271678X15606722 [eCite] [Details]

Citations: Scopus - 5Web of Science - 4

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2016Sutherland BA, Fordsmann JC, Martin C, Neuhaus AA, Witgen BM, et al., 'Multi-modal assessment of neurovascular coupling during cerebral ischaemia and reperfusion using remote middle cerebral artery occlusion', Journal of Cerebral Blood Flow and Metabolism pp. 1-15. ISSN 1559-7016 (2016) [Refereed Article]

DOI: 10.1177/0271678X16669512 [eCite] [Details]

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2015Balami JS, Sutherland BA, Edmunds LD, Grunwald IQ, Neuhaus AA, et al., 'A systematic review and meta-analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke', International journal of stroke, 10, (8) pp. 1168-1178. ISSN 1747-4930 (2015) [Refereed Article]

DOI: 10.1111/ijs.12618 [eCite] [Details]

Citations: Scopus - 24Web of Science - 24

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2015Buchan AM, Karbalai HG, Sutherland BA, 'The future of stroke therapy must not be mired by past arguments', The Lancet, 386, (9994) pp. 654. ISSN 0140-6736 (2015) [Letter or Note in Journal]

[eCite] [Details]

2015Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM, 'Reply: Intravenous thrombolysis for ischaemic strokes: a call for reappraisal', Brain, 138, (4) pp. e342. ISSN 0006-8950 (2015) [Letter or Note in Journal]

DOI: 10.1093/brain/awu283 [eCite] [Details]

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2015Redzic ZB, Rabie T, Sutherland BA, Buchan AM, 'Differential effects of paracrine factors on the survival of cells of the neurovascular unit during oxygen glucose deprivation', International journal of stroke, 10, (3) pp. 407-414. ISSN 1747-4930 (2015) [Refereed Article]

DOI: 10.1111/ijs.12197 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

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2014Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM, 'Reply: Thrombolysis in acute ischaemic stroke', Brain, 137, (1) pp. e282. ISSN 0006-8950 (2014) [Letter or Note in Journal]

DOI: 10.1093/brain/awu066 [eCite] [Details]

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2014Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, et al., 'Capillary pericytes regulate cerebral blood flow in health and disease', Nature, 508, (7494) pp. 55-60. ISSN 0028-0836 (2014) [Refereed Article]

DOI: 10.1038/nature13165 [eCite] [Details]

Citations: Scopus - 281Web of Science - 276

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2014Neuhass AA, Rabie T, Sutherland BA, Papadakis M, Hadley G, et al., 'Importance of preclinical research in the development of neuroprotective strategies for ischemic stroke', JAMA neurology, 71, (5) pp. 634-639. ISSN 2168-6149 (2014) [Refereed Article]

DOI: 10.1001/jamaneurol.2013.6299 [eCite] [Details]

Citations: Scopus - 15Web of Science - 13

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2014Sutherland BA, Buchan AM, 'The life of Bo K. Siesjo, MD, PhD, 1930-2013', International Journal of Stroke, 9, (1) pp. 2-4. ISSN 1747-4930 (2014) [Letter or Note in Journal]

DOI: 10.1111/ijs.12237 [eCite] [Details]

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2013Balami JS, Chen R, Sutherland BA, Buchan AM, 'Thrombolytic Agents for Acute Ischaemic Stroke Treatment: The Past, Present and Future', CNS & neurological disorders drug targets, 12, (2) pp. 145-154. ISSN 1871-5273 (2013) [Refereed Article]

DOI: 10.2174/18715273113129990057 [eCite] [Details]

Citations: Scopus - 12Web of Science - 9

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2013Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM, 'The exact science of stroke thrombolysis and the quiet art of patient selection', Brain, 136, (Pt 12) pp. 3528-3553. ISSN 0006-8950 (2013) [Refereed Article]

DOI: 10.1093/brain/awt201 [eCite] [Details]

Citations: Scopus - 27Web of Science - 23

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2013Balami JS, Sutherland BA, Buchan AM, 'Complications Associated with Recombinant Tissue Plasminogen Activator Therapy for Acute Ischaemic Stroke', CNS & neurological disorders drug targets, 12, (2) pp. 155-169. ISSN 1871-5273 (2013) [Refereed Article]

DOI: 10.2174/18715273112119990050 [eCite] [Details]

Citations: Scopus - 21Web of Science - 16

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2013Sutherland BA, Buchan AM, 'Alteplase treatment does not increase brain injury after mechanical middle cerebral artery occlusion in the rat', Journal of Cerebral Blood Flow and Metabolism, 33, (11) pp. e1-7. ISSN 0271-678X (2013) [Refereed Article]

DOI: 10.1038/jcbfm.2013.148 [eCite] [Details]

Citations: Scopus - 5

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2013Sutherland BA, Harrison JC, Nair SM, Sammut IA, 'Inhalation gases or gaseous mediators as neuroprotectants for cerebral ischaemia', Current drug targets, 14, (1) pp. 56-73. ISSN 1389-4501 (2013) [Refereed Article]

DOI: 10.2174/1389450111314010007 [eCite] [Details]

Citations: Web of Science - 8

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2012Minnerup J, Sutherland BA, Buchan AM, Kleinschnitz C, 'Neuroprotection for Stroke: Current Status and Future Perspectives', International journal of molecular sciences, 13, (9) pp. 11753-117572. ISSN 1422-0067 (2012) [Refereed Article]

DOI: 10.3390/ijms130911753 [eCite] [Details]

Citations: Scopus - 63Web of Science - 53

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2012Sutherland BA, Minnerup J, Balami JS, Arba F, Buchan AM, et al., 'Neuroprotection for ischaemic stroke: Translation from the bench to the bedside', International Journal of Stroke, 7, (5) pp. 407-418. ISSN 1747-4930 (2012) [Refereed Article]

DOI: 10.1111/j.1747-4949.2012.00770.x [eCite] [Details]

Citations: Scopus - 110Web of Science - 101

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2011Nair SM, Rahman RM, Clarkson AN, Sutherland BA, Taurin S, et al., 'Melatonin treatment following stroke induction modulates L-arginine metabolism', Journal of Pineal Research, 51, (3) pp. 313-23. ISSN 0742-3098 (2011) [Refereed Article]

DOI: 10.1111/j.1600-079X.2011.00891.x [eCite] [Details]

Citations: Scopus - 12Web of Science - 12

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2011Rivers JR, Sutherland BA, Ashton JC, 'Characterization of a rat hypoxia-ischemia model where duration of hypoxia is determined by seizure activity', Journal of Neuroscience Methods, 197, (1) pp. 92-96. ISSN 0165-0270 (2011) [Refereed Article]

DOI: 10.1016/j.jneumeth.2011.02.002 [eCite] [Details]

Citations: Scopus - 7Web of Science - 6

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2011Sutherland BA, Papadakis M, Chen R-L, Buchan AM, 'Cerebral blood flow alteration in neuroprotection following cerebral ischaemia', The Journal of physiology, 589, (17) pp. 4105-14. ISSN 0022-3751 (2011) [Refereed Article]

DOI: 10.1113/jphysiol.2011.209601 [eCite] [Details]

Citations: Scopus - 27Web of Science - 24

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2011Sutherland BA, Shaw OM, Clarkson AN, Winburn IC, Errington AC, et al., 'Tin Protoporphyrin Provides Protection Following Cerebral Hypoxia-Ischemia: Involvement of Alternative Pathways', Journal of neuroscience research, 89 pp. 1284-1294. ISSN 0360-4012 (2011) [Refereed Article]

DOI: 10.1002/jnr.22661 [eCite] [Details]

Citations: Scopus - 2

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2010Harston GWJ, Sutherland BA, Kennedy J, Buchan AM, 'The contribution of L-arginine to the neurotoxicity of recombinant tissue plasminogen activator following cerebral ischemia: a review of rtPA neurotoxicity', Journal of Cerebral Blood Flow and Metabolism, 30, (11) pp. 1804-1816. ISSN 0271-678X (2010) [Refereed Article]

DOI: 10.1038/jcbfm.2010.149 [eCite] [Details]

Citations: Scopus - 27Web of Science - 27

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2009Sutherland BA, Rahman RM, Clarkson AN, Shaw OM, Nair SM, et al., 'Cerebral heme oxygenase 1 and 2 spatial distribution is modulated following injury from hypoxia-ischemia and middle cerebral artery occlusion in rats', Neuroscience Research, 65, (4) pp. 326-334. ISSN 0168-0102 (2009) [Refereed Article]

DOI: 10.1016/j.neures.2009.08.007 [eCite] [Details]

Citations: Scopus - 20Web of Science - 19

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2007Ashton JC, Rahman RM, Nair SM, Sutherland BA, Glass M, et al., 'Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain', Neuroscience letters, 412, (2) pp. 114-117. ISSN 0304-3940 (2007) [Refereed Article]

DOI: 10.1016/j.neulet.2006.10.053 [eCite] [Details]

Citations: Scopus - 93Web of Science - 82

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2006Sutherland BA, Rahman RM, Appleton I, 'Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration', Journal of Nutritional Biochemistry, 17, (5) pp. 291 - 306. ISSN 0955-2863 (2006) [Refereed Article]

DOI: 10.1016/j.jnutbio.2005.10.005 [eCite] [Details]

Citations: Scopus - 190Web of Science - 153

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2005Clarkson AN, Sutherland BA, Appleton I, 'The biology and pathology of hypoxia-ischemia: an update', Archivum immunologiae et therapiae experimentalis, 53, (3) pp. 213-225. ISSN 0004-069X (2005) [Refereed Article]

PMID: 15995582 [eCite] [Details]

Citations: Web of Science - 43

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2005Sutherland BA, Shaw OM, Clarkson AN, Jackson DM, Sammut IA, et al., 'Neuroprotective effects of (-)-epigallocatechin gallate after hypoxia-ischemia-induced brain damage: novel mechanisms of action', The FASEB Journal, 19, (2) pp. 258-260. ISSN 1530-6860 (2005) [Refereed Article]

DOI: 10.1096/fj.04-2806fje [eCite] [Details]

Citations: Scopus - 97Web of Science - 18

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Chapter in Book

(2 outputs)
YearCitationAltmetrics
2016Hoyte LC, Sutherland BA, Buchan AM, 'Animal models of stroke', Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, J Stein (ed), United States, pp. 1-10. ISBN 978-0-12-809324-5 (2016) [Other Book Chapter]

DOI: 10.1016/B978-0-12-809324-5.02030-7 [eCite] [Details]

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2014Sutherland BA, Rabie T, Buchan AM, 'Laser Doppler Flowmetry to Measure Changes in Cerebral Blood Flow', Cerebral Angiogenesis Methods and Protocols, Humana Press, R Milner (ed), United Kingdom, pp. 237-248. ISBN 978-1-4939-0320-7 (2014) [Research Book Chapter]

DOI: 10.1007/978-1-4939-0320-7_20 [eCite] [Details]

Citations: Scopus - 2

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Conference Publication

(1 outputs)
YearCitationAltmetrics
2014Sutherland BA, 'Keynote speaker: pre-clinical research the potential therapeutic opportunities for various gases including oxygen', British Hyperbaric Association Annual Meeting, 7-8 November, 2014, Hull, United Kingdom (2014) [Keynote Presentation]

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Grants & Funding

Brad has previously held grants from the Medical Research Council, John Fell Fund, Wellcome Trust Institutional Strategic Support Fund and Medical Research Fund while working at the University of Oxford (UK).

Funding Summary

Number of grants

1

Total funding

$20,000

Projects

Squeezed to death by pericytes: a new target for ischaemic stroke treatment (2017)$20,000
Funding
University of Tasmania ($20,000)
Scheme
Grant- Research Enhancement Program
Administered By
University of Tasmania
Research Team
Sutherland BA
Year
2017

Research Supervision

Brad has co-supervised two PhD students and one Masters student while working at the University Oxford (UK). Brad is currently available to take on supervision of Higher Degree Research Students in the Faculty of Health.

Current

1

Current

DegreeTitleCommenced
PhDPericyte Regulation of Blood Flow in the Brain and its Dysfunction Following Stroke2017