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David Gell

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Dave Gell

Postdoctoral Research Fellow

Medical Science 2, Hobart CBD Campuses

+61 6226 4608 (phone)

David.Gell@utas.edu.au

Dr Dave Gell is a Research Fellow at the School of Medicine in the Faculty of Health. He is a structural biologist.

Biography

Dave studied Natural Sciences at the University of Cambridge. He received his PhD in 2000, on molecular mechanisms of mammalian DNA repair, from the University of Cambridge, under supervision of Professor Stephen Jackson. He carried out postdoctoral work with Professor Joel Mackay at the University of Sydney (2000–2010), where he trained in structural biology and physical biochemistry. Dave combines molecular biology, biochemistry and structural biology to understand protein function.

Career summary

Qualifications

  • PhD, University of Cambridge, UK, 2000. Thesis: Molecular analysis of DNA-dependent protein kinase
  • MA (Natural Sciences), University of Cambridge, UK. 1993

Memberships

Professional practice

  • Australian and New Zealand Society for Magnetic Resonance (current)
  • Melbourne Protein Group (current)
  • Tasmanian State Representative of the Australian Society for Biochemistry and Molecular Biology (past)

Administrative expertise

Teaching

Protein Structure, Biochemistry, Molecular Biology, Structural Biology, Haemoglobin, Protein Function, Cell Biology

Teaching responsibility

Dr Gell currently teaches:

Research Invitations

Recent speaker invitations:

  • Nov 2014             Queensland Protein Group (Brisbane) 
  • Sept 2014            Combio 2014 Conference (Canberra)     
  • April 2013            University of Wollongong, School of Chemistry (Wollongong)

View more on Dr David Gell in WARP

Expertise

  •  Protein function
  •  Protein structure
  • Structural biology
  • Metalloproteins
  • Nuclear magnetic resonance
  • X-ray crystallography
  • Physical biochemistry
  • Protein engineering
  • Haemoglobin

Research Themes

David's research aligns to the University's research theme of Better Health. His research has contributed to understanding how haemoglobin is made in developing red blood cells, and how some pathogenic bacteria can steal iron from human haemoglobin in order to support infection. He is currently engineering proteins with customised functions that can be used to mark and/or control the function of neurons with Dr John Lin, in order to understand brain function and dysfunction.

Collaboration

Dr Gell has collaborations with Mitchell Weiss (Children's Hospital of Philadelphia, USA) and Robert Clubb (UCLA, USA), Joel Mackay (University of Sydney), and Mitchell Guss (University of Sydney) have advanced understand of how haemoglobin is made in developing red blood cells, and the structure and function of haemoglobin-scavenging receptors in pathogenic Staphylococcus aureus.

Awards

  • ARC Australian Research Fellow (ARF) (2007-11)
  • Australian Society for Biochemistry and Molecular Biology Edman award (2004)
  • ARC Australian Post Doctoral Fellow (APD) (2003-05)
  • Wellcome Trust International Prize Travelling Post Doctoral Research Fellow (2001-02)

Current projects

  • Optogenetic approaches to measure and control neuronal function 
  • Structure and function of haemoglobin-binding and haem-scavenging proteins in pathogenic bacteria

Fields of Research

  • Structural Biology (incl. Macromolecular Modelling) (060112)
  • Enzymes (060107)
  • Medical Bacteriology (110801)
  • Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) (110106)
  • Cellular Nervous System (110902)
  • Central Nervous System (110903)
  • Cell Development, Proliferation and Death (060103)
  • Biochemistry and Cell Biology (060199)
  • Clinical Pharmacology and Therapeutics (111502)
  • Bacteriology (060501)
  • Epidemiology (111706)
  • Infectious Diseases (110309)
  • Synthetic Biology (060113)
  • Signal Transduction (060111)
  • Medical Biochemistry and Metabolomics (110199)
  • Cell Metabolism (060104)
  • Biologically Active Molecules (030401)
  • Cell Neurochemistry (060105)
  • Plant Biology (060799)
  • Medical Molecular Engineering of Nucleic Acids and Proteins (100403)
  • Separation Science (030108)
  • Transition Metal Chemistry (030207)

Research Objectives

  • Expanding Knowledge in the Biological Sciences (970106)
  • Infectious Diseases (920109)
  • Blood Disorders (920101)
  • Nervous System and Disorders (920111)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Human Pharmaceutical Treatments (e.g. Antibiotics) (860803)
  • Cardiovascular System and Diseases (920103)
  • Preventive Medicine (920412)
  • Health Education and Promotion (920205)
  • Human Pharmaceutical Products (860899)
  • Respiratory System and Diseases (incl. Asthma) (920115)
  • Expanding Knowledge in the Chemical Sciences (970103)
  • Endocrine Organs and Diseases (excl. Diabetes) (920106)
  • Diagnostic Methods (920203)
  • Expanding Knowledge in Technology (970110)
  • Health and Support Services (920299)

Publications

Dr Gell regularly reviews manuscripts for journals including Journal of Molecular Biology, Biochemistry, Journal of the America Chemical Society (JACS), Blood, European Biophysics Journal, Journal of neurochemistry and Biochimica et Biophysica Acta (BBA)

In total he has over 30 original research articles and several reviews and book chapters that together have received over 2000 citations. The high quality of Dr Gell's work has been recognised by publications in Cell (2004),J Clin Invest (2004, 2007) and Nature (2005).

In addition Dr Gell has a UK patent GB2351494, registered to Kudos Pharmaceuticals (2000), Interactions of Ku polypeptides and application thereof .

Total publications

52

Highlighted publications

(5 outputs)
YearTypeCitationAltmetrics
2015Journal ArticleDickson CF, Jacques DA, Clubb RT, Guss JM, Gell DA, 'The structure of haemoglobin bound to the haemoglobin receptor IsdH from Staphylococcus aureus shows disruption of the native α-globin haem pocket', Acta Crystallographica. Section D: Biological Crystallography, 71 pp. 1295-1306. ISSN 0907-4449 (2015) [Refereed Article]

DOI: 10.1107/S1399004715005817 [eCite] [Details]

Citations: Scopus - 6Web of Science - 5

Co-authors: Dickson CF

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2014Journal ArticleDickson CF, Kumar KK, Jacques DA, Malmirchegini GR, Spirig T, et al., 'Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus', Journal of Biological Chemistry, 289, (10) pp. 6728-6738. ISSN 0021-9258 (2014) [Refereed Article]

DOI: 10.1074/jbc.M113.545566 [eCite] [Details]

Citations: Scopus - 24Web of Science - 23

Co-authors: Dickson CF

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2011Journal ArticleKumar KK, Jacques DA, Pishchany G, Caradoc-Davies T, Spirig T, et al., 'Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH', Journal of Biological Chemistry, 286, (44) pp. 38439-38447. ISSN 0021-9258 (2011) [Refereed Article]

DOI: 10.1074/jbc.M111.287300 [eCite] [Details]

Citations: Scopus - 39Web of Science - 43

Co-authors: Dickson CF

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2005Journal ArticleFeng L, Zhou S, Gu L, Gell DA, Mackay JP, et al., 'Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem', Nature: International Weekly Journal of Science, 435, (7042) pp. 697-701. ISSN 0028-0836 (2005) [Refereed Article]

DOI: 10.1038/nature03609 [eCite] [Details]

Citations: Scopus - 85Web of Science - 82

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2004Journal ArticleFeng L, Gell DA, Zhou S, Gu L, Kong Y, et al., 'Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin', Cell, 119, (5) pp. 629-640. ISSN 0092-8674 (2004) [Refereed Article]

DOI: 10.1016/j.cell.2004.11.025 [eCite] [Details]

Citations: Scopus - 110Web of Science - 100

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Journal Article

(47 outputs)
YearCitationAltmetrics
2018Gao J-L, Kwan AH, Yammine A, Zhou X, Trewhella J, et al., 'Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis', Nature Communications, 9 Article 4097. ISSN 2041-1723 (2018) [Refereed Article]

DOI: 10.1038/s41467-018-06470-0 [eCite] [Details]

Co-authors: Horne J

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2018Sjodt M, Macdonald R, Marshall JD, Clayton J, Olson JS, et al., 'Energetics underlying hemin extraction from human hemoglobin by Staphylococcus aureus', Journal of Biological Chemistry, 293, (18) pp. 6942-6957. ISSN 0021-9258 (2018) [Refereed Article]

DOI: 10.1074/jbc.RA117.000803 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2018Wanandy T, Wilson R, Gell D, Rose HE, Gueven N, et al., 'Towards complete identification of allergens in Jack Jumper (Myrmecia pilosula) ant venom and their clinical relevance: An immunoproteomic approach', Clinical and Experimental Allergy, 48, (9) pp. 1222-1234. ISSN 1365-2222 (2018) [Refereed Article]

DOI: 10.1111/cea.13224 [eCite] [Details]

Citations: Scopus - 1

Co-authors: Wilson R; Gueven N; Davies NW; Brown SGA

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2017Latham RD, Gell DA, Fairbairn RL, Lyons AB, Shukla SD, et al., 'An isolate of Haemophilus haemolyticus produces a bacteriocin-like substance that inhibits the growth of nontypeable Haemophilus influenzae', International Journal of Antimicrobial Agents, 49, (4) pp. 503-506. ISSN 0924-8579 (2017) [Refereed Article]

DOI: 10.1016/j.ijantimicag.2016.12.010 [eCite] [Details]

Co-authors: Latham RD; Lyons AB; Shukla SD; Tristram SG

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2016Choo JM, Cheung JK, Wisniewski JA, Steer DL, Bulach DM, et al., 'The NEAT domain-containing proteins of Clostridium perfringens bind heme', PLoS One, 11, (9) Article e0162981. ISSN 1932-6203 (2016) [Refereed Article]

DOI: 10.1371/journal.pone.0162981 [eCite] [Details]

Citations: Scopus - 4Web of Science - 2

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2016Shukla SD, Fairbairn RL, Gell DA, Latham RD, Sohal SS, et al., 'An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke', International Journal of Chronic Obstructive Pulmonary Disease, 11, (1) pp. 1647-1655. ISSN 1178-2005 (2016) [Refereed Article]

DOI: 10.2147/COPD.S108698 [eCite] [Details]

Citations: Scopus - 12Web of Science - 14

Co-authors: Latham RD; Sohal SS; Walters EH; O'Toole RF

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2016Saederup KL, Stodkilde K, Graversen JH, Dickson CF, Etzerodt A, et al., 'The Staphylococcus aureus protein IsdH inhibits host hemoglobin scavenging to promote heme acquisition by the pathogen', Journal of Biological Chemistry, 291, (46) pp. 23989-23997. ISSN 0021-9258 (2016) [Refereed Article]

DOI: 10.1074/jbc.M116.755934 [eCite] [Details]

Citations: Scopus - 11Web of Science - 9

Co-authors: Dickson CF

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2015Dickson CF, Jacques DA, Clubb RT, Guss JM, Gell DA, 'The structure of haemoglobin bound to the haemoglobin receptor IsdH from Staphylococcus aureus shows disruption of the native α-globin haem pocket', Acta Crystallographica. Section D: Biological Crystallography, 71 pp. 1295-1306. ISSN 0907-4449 (2015) [Refereed Article]

DOI: 10.1107/S1399004715005817 [eCite] [Details]

Citations: Scopus - 6Web of Science - 5

Co-authors: Dickson CF

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2015Sjodt M, Macdonald R, Spirig T, Chan AH, Dickson CF, et al., 'The PRE-derived NMR model of the 38.8-kDa tri-domain IsdH protein from Staphylococcus aureus suggests that it adaptively recognizes human hemoglobin', Journal of Molecular Biology, 428, (6) pp. 1107-1129. ISSN 0022-2836 (2015) [Refereed Article]

DOI: 10.1016/j.jmb.2015.02.008 [eCite] [Details]

Citations: Scopus - 10Web of Science - 10

Co-authors: Dickson CF

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2014Dickson CF, Kumar KK, Jacques DA, Malmirchegini GR, Spirig T, et al., 'Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus', Journal of Biological Chemistry, 289, (10) pp. 6728-6738. ISSN 0021-9258 (2014) [Refereed Article]

DOI: 10.1074/jbc.M113.545566 [eCite] [Details]

Citations: Scopus - 24Web of Science - 23

Co-authors: Dickson CF

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2014Kumar KK, Jacques DA, Guss JM, Gell DA, 'The structure of α-haemoglobin in complex with a haemoglobin-binding domain from Staphylococcus aureus reveals the elusive α-haemoglobin dimerization interface', Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 70, (8) pp. 1032-1037. ISSN 1744-3091 (2014) [Refereed Article]

DOI: 10.1107/S2053230X14012175 [eCite] [Details]

Citations: Scopus - 2Web of Science - 1

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2014Pishchany G, Sheldon JR, Dickson CF, Alam MT, Read TD, et al., 'IsdB-dependent hemoglobin binding is required for acquisition of heme by Staphylococcus aureus', Journal of Infectious Diseases, 209, (11) pp. 1764-1772. ISSN 0022-1899 (2014) [Refereed Article]

DOI: 10.1093/infdis/jit817 [eCite] [Details]

Citations: Scopus - 30Web of Science - 33

Co-authors: Dickson CF

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2013Dickson CF, Rich AM, D'Avigdor WMH, Collins DAT, Lowry JA, et al., 'α-Hemoglobin-stabilizing Protein (AHSP) perturbs the proximal heme pocket of oxy-α-hemoglobin and weakens the iron-oxygen bond', Journal of Biological Chemistry, 288, (27) pp. 19986-20001. ISSN 0021-9258 (2013) [Refereed Article]

DOI: 10.1074/jbc.M112.437509 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

Co-authors: Dickson CF

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2013Cordina NM, Liew CK, Gell DA, Fajer PG, MacKay JP, et al., 'Effects of calcium binding and the hypertrophic cardiomyopathy A8V mutation on the dynamic equilibrium between closed and open conformations of the regulatory N-domain of isolated cardiac troponin C', Biochemistry, 52, (11) pp. 1950-1962. ISSN 0006-2960 (2013) [Refereed Article]

DOI: 10.1021/bi4000172 [eCite] [Details]

Citations: Scopus - 21Web of Science - 21

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2013Thom CS, Dickson CF, Gell DA, Weiss MJ, 'Hemoglobin variants: biochemical properties and clinical correlates', Cold Spring Harbor Perspectives in Medicine, 3, (3) pp. 1-22. ISSN 2157-1422 (2013) [Refereed Article]

DOI: 10.1101/cshperspect.a011858 [eCite] [Details]

Citations: Scopus - 56Web of Science - 45

Co-authors: Dickson CF

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2013Spirig T, Malmirchegini GR, Zhang J, Robson SA, Sjodt M, et al., 'Staphylococcus aureus uses a novel multidomain receptor to break apart human hemoglobin and steal its heme', Journal of Biological Chemistry, 288, (2) pp. 1065-1078. ISSN 0021-9258 (2013) [Refereed Article]

DOI: 10.1074/jbc.M112.419119 [eCite] [Details]

Citations: Scopus - 29Web of Science - 29

Co-authors: Dickson CF

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2012Cordina NM, Liew CK, Gell DA, Fajer PG, Mackay JP, et al., 'Interdomain orientation of cardiac Troponin C characterized by paramagnetic relaxation enhancement NMR reveals a compact state', Protein Science, 21, (9) pp. 1376-1387. ISSN 1469-896X (2012) [Refereed Article]

DOI: 10.1002/pro.2124 [eCite] [Details]

Citations: Scopus - 10Web of Science - 11

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2012Khandros E, Mollan TL, Yu X, Wang X, Yao Y, et al., 'Insights into Hemoglobin Assembly through in Vivo Mutagenesis of α-Hemoglobin Stabilizing Protein', Journal of Biological Chemistry, 287, (14) pp. 11325-11337. ISSN 0021-9258 (2012) [Refereed Article]

DOI: 10.1074/jbc.M111.313205 [eCite] [Details]

Citations: Scopus - 13Web of Science - 11

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2012Pankhurst MW, Gell DA, Butler CW, Kirkcaldie MTK, West AK, et al., 'Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury', Pl o S One, 7, (2) Article e31185. ISSN 1932-6203 (2012) [Refereed Article]

DOI: 10.1371/journal.pone.0031185 [eCite] [Details]

Citations: Scopus - 8Web of Science - 5

Co-authors: Pankhurst MW; Butler CW; Kirkcaldie MTK; West AK; Chung RS

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2011Kumar KK, Jacques DA, Pishchany G, Caradoc-Davies T, Spirig T, et al., 'Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH', Journal of Biological Chemistry, 286, (44) pp. 38439-38447. ISSN 0021-9258 (2011) [Refereed Article]

DOI: 10.1074/jbc.M111.287300 [eCite] [Details]

Citations: Scopus - 39Web of Science - 43

Co-authors: Dickson CF

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2010Kumar KK, Dickson CF, Weiss MJ, Mackay JP, Gell DA, 'AHSP (α-haemoglobin-stabilizing protein) stabilizes apo-α-haemoglobin in a partially folded state', Biochemical Journal, 432, (2) pp. 275-282. ISSN 0264-6021 (2010) [Refereed Article]

DOI: 10.1042/BJ20100642 [eCite] [Details]

Citations: Scopus - 10Web of Science - 10

Co-authors: Dickson CF

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2010Schwalbe M, Dutta K, Libich DS, Venugopal H, Claridge JK, et al., 'Two-state conformational equilibrium in the Par-4 leucine zipper domain', Proteins: Structure, Function, and Genetics, 78, (11) pp. 2433-2449. ISSN 0887-3585 (2010) [Refereed Article]

DOI: 10.1002/prot.22752 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

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2010Tao L, Xu J, Gell D, Davis TP, 'Synthesis, Characterization, and Bioactivity of Mid-Functional PolyHPMA-Lysozyme Bioconjugates ', Macromolecules, 43, (8) pp. 3721-3727. ISSN 0024-9297 (2010) [Refereed Article]

DOI: 10.1021/ma100142w [eCite] [Details]

Citations: Scopus - 47Web of Science - 45

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2009Gell DA, Feng L, Zhou S, Jeffrey PD, Bendak K, et al., 'A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin', Journal of Biological Chemistry, 284, (43) pp. 29462-29469. ISSN 0021-9258 (2009) [Refereed Article]

DOI: 10.1074/jbc.M109.027045 [eCite] [Details]

Citations: Scopus - 16Web of Science - 15

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2007Yu X, Kong Y, Dore LC, Abdulmalik O, Katein AM, et al., 'An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis', Journal of Clinical Investigation, 117, (7) pp. 1856-1865. ISSN 0021-9738 (2007) [Refereed Article]

DOI: 10.1172/JCI31664 [eCite] [Details]

Citations: Scopus - 77Web of Science - 74

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2006Gell DA, Westman BJ, Gorman D, Liew C, Welch JJ, et al., 'A novel haem-binding interface in the 22 kDa haem-binding protein p22HBP', Journal of Molecular Biology, 362, (2) pp. 287-297. ISSN 0022-2836 (2006) [Refereed Article]

DOI: 10.1016/j.jmb.2006.07.010 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

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2005Weiss MJ, Zhou S, Feng L, Gell DA, Mackay JP, et al., 'Role of alpha hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia', New York Academy of Sciences. Annals, 1054, (1) pp. 103-117. ISSN 0077-8923 (2005) [Refereed Article]

DOI: 10.1196/annals.1345.013 [eCite] [Details]

Citations: Scopus - 34Web of Science - 30

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2005Feng L, Zhou S, Gu L, Gell DA, Mackay JP, et al., 'Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem', Nature: International Weekly Journal of Science, 435, (7042) pp. 697-701. ISSN 0028-0836 (2005) [Refereed Article]

DOI: 10.1038/nature03609 [eCite] [Details]

Citations: Scopus - 85Web of Science - 82

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2004Feng L, Gell DA, Zhou S, Gu L, Kong Y, et al., 'Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin', Cell, 119, (5) pp. 629-640. ISSN 0092-8674 (2004) [Refereed Article]

DOI: 10.1016/j.cell.2004.11.025 [eCite] [Details]

Citations: Scopus - 110Web of Science - 100

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2004Kong Y, Zhou S, Kihm AJ, Katein AM, Yu X, et al., 'Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia', Journal of Clinical Investigation, 114, (10) pp. 1457-1466. ISSN 0021-9738 (2004) [Refereed Article]

DOI: 10.1172/JCI200421982 [eCite] [Details]

Citations: Scopus - 110Web of Science - 108

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2003Kwan AH, Gell DA, Verger A, Crossley M, Matthews JM, et al., 'Engineering a protein scaffold from a PHD finger', Structure, 11, (7) pp. 803-813. ISSN 0969-2126 (2003) [Refereed Article]

DOI: 10.1016/S0969-2126(03)00122-9 [eCite] [Details]

Citations: Scopus - 47Web of Science - 46

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2002Gell D, Kong Y, Eaton SA, Weiss MJ, Mackay JP, 'Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein', Journal of Biological Chemistry, 277, (43) pp. 40602-40609. ISSN 0021-9258 (2002) [Refereed Article]

DOI: 10.1074/jbc.M206084200 [eCite] [Details]

Citations: Scopus - 89Web of Science - 78

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2002Kowalski K, Liew CK, Matthews JM, Gell DA, Crossley M, et al., 'Characterization of the conserved interaction between GATA and FOG family proteins', Journal of Biological Chemistry, 277, (38) pp. 35720-35729. ISSN 0021-9258 (2002) [Refereed Article]

DOI: 10.1074/jbc.M204663200 [eCite] [Details]

Citations: Scopus - 18Web of Science - 16

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2002Sharpe BK, Matthews JM, Kwan AH, Newton A, Gell DA, et al., 'A new zinc binding fold underlines the versatility of zinc binding modules in protein evolution ', Structure, 10, (5) pp. 639-648. ISSN 0969-2126 (2002) [Refereed Article]

DOI: 10.1016/S0969-2126(02)00757-8 [eCite] [Details]

Citations: Scopus - 19Web of Science - 18

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2002Westman BJ, Mackay JP, Gell D, 'Ikaros: a key regulator of haematopoiesis', International Journal of Biochemistry and Cell Biology, 34, (10) pp. 1304-1307. ISSN 1357-2725 (2002) [Refereed Article]

DOI: 10.1016/S1357-2725(02)00070-5 [eCite] [Details]

Citations: Scopus - 21Web of Science - 19

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2001Herceg Z, Hulla W, Gell D, Cuenin C, Lleonart M, et al., 'Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression', Nature Genetics, 29, (2) pp. 206-211. ISSN 1061-4036 (2001) [Refereed Article]

DOI: 10.1038/ng725 [eCite] [Details]

Citations: Scopus - 85Web of Science - 84

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2000Errami A, Overkamp WJ, He DM, Friedl AA, Gell DA, et al., 'A new X-ray sensitive CHO cell mutant of ionizing radiation group 7,XR-C2, that is defective in DSB repair but has only a mild defect in V(D)J recombination ', Mutation Research - DNA Repair, 461, (1) pp. 59-69. ISSN 0921-8777 (2000) [Refereed Article]

DOI: 10.1016/S0921-8777(00)00038-0 [eCite] [Details]

Citations: Scopus - 13Web of Science - 14

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1999Gell D, Jackson SP, 'Mapping of protein-protein interactions within the DNA-dependent protein kinase complex', Nucleic Acids Research, 27, (17) pp. 3494-3502. ISSN 0305-1048 (1999) [Refereed Article]

DOI: 10.1093/nar/27.17.3494 [eCite] [Details]

Citations: Scopus - 146Web of Science - 141

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1998Priestley A, Beamish HJ, Gell D, Amatucci AG, Muhlmann-Diaz MC, et al., 'Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20', Nucleic Acids Research, 26, (8) pp. 1965-1973. ISSN 0305-1048 (1998) [Refereed Article]

DOI: 10.1093/nar/26.8.1965 [eCite] [Details]

Citations: Scopus - 72Web of Science - 69

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1998Taccioli GE, Amatucci AG, Beamish HJ, Gell D, Xiang XH, et al., 'Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity ', Immunity, 9, (3) pp. 355-366. ISSN 1074-7613 (1998) [Refereed Article]

DOI: 10.1016/S1074-7613(00)80618-4 [eCite] [Details]

Citations: Scopus - 236Web of Science - 233

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1997Badie C, Goodhardt M, Waugh A, Doyen N, Foray N, et al., 'A DNA double-strand break defective fibroblast cell line (180BR) derived from a radiosensitive patient represents a new mutant phenotype ', Cancer Research, 57, (20) pp. 4600-4607. ISSN 0008-5472 (1997) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 42

1997Raats JM, Gell D, Vickers L, Heasman J, Wylie C, 'Modified mRNA rescue of maternal CK1/8 mRNA depletion in Xenopus oocytes', Antisense and Nucleic Acid Drug Development, 7, (4) pp. 263-277. ISSN 1087-2906 (1997) [Refereed Article]

DOI: 10.1089/oli.1.1997.7.263 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

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1997Singleton BK, Priestley A, Steingrimsdottir H, Gell D, Blunt T, et al., 'Molecular and biochemical characterization of xrs mutants defective in Ku80', Molecular and Cellular Biology, 17, (3) pp. 1264-1273. ISSN 0270-7306 (1997) [Refereed Article]

DOI: 10.1128/MCB.17.3.1264 [eCite] [Details]

Citations: Scopus - 154Web of Science - 151

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1996Blunt T, Gell D, Fox M, Taccioli GE, Lehmann AR, et al., 'Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse ', National Academy of Sciences of The United States of America. Proceedings, 93, (19) pp. 10285-10290. ISSN 0027-8424 (1996) [Refereed Article]

DOI: 10.1073/pnas.93.19.10285 [eCite] [Details]

Citations: Scopus - 281Web of Science - 265

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1995Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, et al., 'DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product ', Cell, 82, (5) pp. 849-856. ISSN 0092-8674 (1995) [Refereed Article]

DOI: 10.1016/0092-8674(95)90482-4 [eCite] [Details]

Citations: Scopus - 627Web of Science - 638

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1995Miller RD, Hogg J, Ozaki JH, Gell D, Jackson SP, et al., 'Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus', National Academy of Sciences of The United States of America. Proceedings, 92, (23) pp. 10792-10795. ISSN 0027-8424 (1995) [Refereed Article]

DOI: 10.1073/pnas.92.23.10792 [eCite] [Details]

Citations: Scopus - 57Web of Science - 49

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1994Meadows LA, Gell D, Broadie K, Gould AP, White RA, 'The cell adhesion molecule, connectin, and the development of the Drosophila neuromuscular system', Journal of Cell Science, 107 pp. 321-328. ISSN 0021-9533 (1994) [Refereed Article]

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Citations: Web of Science - 51

Chapter in Book

(4 outputs)
YearCitationAltmetrics
2017Gell DA, Kwan AN, Mackay JP, 'NMR Spectroscopy in the Analysis of Protein-Protein Interactions', Modern Magnetic Resonance, Springer International Publishing, GA Webb (ed), pp. 1-34. ISBN 978-3-319-28275-6 (2017) [Other Book Chapter]

DOI: 10.1007/978-3-319-28275-6_121-1 [eCite] [Details]

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2012Gell DA, Grant RP, Mackay JP, 'The detection and quantitation of protein oligomerization', Advances in Experimental Medicine and Biology: Protein Dimerization and Oligomerization in Biology, Springer, JM Matthews (ed), New York, United States, pp. 19-41. ISBN 978-146143228-9 (2012) [Research Book Chapter]

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2006Gell DA, Mackay JP, 'NMR spectroscopy in the analysis of protein-protein interactions', Modern Magnetic Resonance, Springer, GA Webb (ed), Dordrecht, The Netherlands, pp. 1321-1328. ISBN 978-1-4020-3894-5 (2006) [Research Book Chapter]

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2003Gell DA, Crossley M, Mackay JP, 'Zinc-finger Genes', Encyclopedia of the Human Genome, John Wily & Sons Ltd, DN Cooper (ed), Chichester, pp. 823-828. ISBN 978-0-470-01618-3 (2003) [Research Book Chapter]

DOI: 10.1038/npg.els.0005047 [eCite] [Details]

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Conference Publication

(1 outputs)
YearCitationAltmetrics
2016Shukla S, Fairbairn R, Gell DA, Smith JA, Walters EH, et al., 'An antagonist of the platelet-activating factor receptor inhibits streptococcus pneumoniae and non-typeable haemophilus influenzae infection of human bronchial epithelial cells exposed to cigarette smoke', Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, 1-6 April 2016, Perth, Australia (2016) [Conference Extract]

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Co-authors: Smith JA; Walters EH; O'Toole RF

Grants & Funding

Over his research career Dr Gell has been lead or co-CI on National Competitive Grants projects worth >$2.5M (since 2002). He has won ~ $60,000 from competitive internal schemes. In 2011, he played a steering role as a CI in a successful ARC LIEF grant ($630,000) for a 600 MHz NMR spectrometer at the University of Tasmania.

Funding Summary

Number of grants

10

Total funding

$1,962,400

Projects

Potential therapeutic value of normal throat bacteria that produce a novel inhibitory substance for the prevention of respiratory infections (2018)$19,000
Description
We have discovered a strain of a harmless bacterial species that lives in the throats of healthy people that produces a novel substance that inhibits the growth of the respiratory pathogen Haemophilus influenzae. The study involves an evaluation of the potential of this strain as a respiratory probiotic.
Funding
Clifford Craig Foundation ($19,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Tristram SG; Kunde DA; Gell DA
Year
2018
Biophysical characterisation of the haemoglobin receptor from Streptococcus pyogenes (2012)$8,810
Funding
The Select Foundation ($8,810)
Scheme
Grant-Small Grants Scheme
Administered By
University of Tasmania
Research Team
Dickson CF; Gell DA
Year
2012
The role of store-operated calcium entry in neuronal development (2012 - 2014)$341,175
Funding
National Health & Medical Research Council ($341,175)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Foa LC; Small DH; Gell DA
Period
2012 - 2014
Grant Reference
1024145
Purchase of a high resolution NMR spectrometer with liquid chromatography module (2012)$630,000
Description
This proposal seeks support for a high resolution Nuclear Magnetic Resonance spectrometer with a liquid chromatographic separation module for the Central Science Laboratory at the University of Tasmania. This will be a shared facility supporting a diversity of researchers in the broader Tasmanian scientific community. Access to recent advances in instrument technology is essential to support internationally competitive research programs into areas of Human health, plant biology and agriculture, aquaculture, food science, materials technology, separation science and chemical synthesis.
Funding
Australian Research Council ($630,000)
Scheme
Grant-Linkage Infrastructure
Administered By
University of Tasmania
Research Team
Reid JB; Hilder EF; Gell DA; McGuinness DS; Ross JJ
Year
2012
Grant Reference
LE1210018
Rising Stars 3 (2011 - 2013)$51,000
Funding
University of Tasmania ($51,000)
Scheme
Grant-Rising Stars Round 3
Administered By
University of Tasmania
Research Team
Gell DA
Period
2011 - 2013
Australian Synchrotron Beamline Proposal Access Travel Award (2011)$1,415
Funding
Australian Synchrotron ($1,415)
Scheme
Grant-Travel
Administered By
University of Tasmania
Research Team
Gell DA
Year
2011
David Gell - Discretionary Account (2010)$24,000
Funding
Menzies Institute for Medical Research ($24,000)
Scheme
Consultancy
Administered By
University of Tasmania
Research Team
Gell DA
Year
2010
Investigating the molecular function of alpha-Haemoglobin stabilising protein (2010 - 2011)$240,000
Funding
Australian Research Council ($240,000)
Scheme
Grant-Discovery Projects
Administered By
Australian Research Council
Research Team
Gell DA
Period
2010 - 2011
Grant Reference
DP0773140
How does the LRP receptor megalin promote regenerative neuronal growth? (2009 - 2011)$392,750
Funding
National Health & Medical Research Council ($392,750)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Chung RS; West AK; Gell DA; Cheung NS
Period
2009 - 2011
Grant Reference
544913
The role of alpha-haemoglobin stabilising protein in haemoglobin production and as a therapeutic for thalassaemia (2009 - 2011)$254,250
Funding
National Health & Medical Research Council ($254,250)
Scheme
Grant-Project
Administered By
National Health & Medical Research Council
Research Team
Gell DA; Weiss Mitchell
Period
2009 - 2011
Grant Reference
570876

Research Supervision

Dr Gell has successfully supervised 2 PhD candidates to completion, both of whom have gone on to secure prestigious post doctoral positions. Dr Gell currently supervises several PhD and Honours students.

Current

3

Completed

3

Current

DegreeTitleCommenced
PhDPharmaceutical Studies on Jack Jumper Ant Venom Immunotherapy Products2012
PhDDevelopment of Optogenetic Approaches to Modulate Synaptic Plasticity in the Postsynaptic Cells2014
PhDOptogenetic Manipulation of Calcineurin Signalling2015

Completed

DegreeTitleCompleted
PhDAn Investigation of the Inhibition of Non-typeable Haemophilus influenzae, by Substances Secreted by Haemophilus haemolyticus
Candidate: Roger Declan Latham
2018
PhDThe Role of the CC-Chemokine Receptor 6, CCR6, in B Cell Differentiation During the Humoral Immune Response
Candidate: Jennifer Bannan
2015
PhDMolecular Mechanisms Used by Staphylococcus Aureus to Access Iron from Human Haemoglobin
Candidate: Claire Frances Dickson
2014