Profiles

Rahul Patel

UTAS Home Dr Rahul Patel

Rahul Patel

Lecturer in Pharmacological Sciences

Room 4015, Level 4, Pharmacy Building, Sandy Bay Campus

+61 3 6226 1079 (phone)

+61 3 6226 2870 (fax)

Rahul.Patel@utas.edu.au

Dr Patel is a lecturer in Pharmacological Sciences, Division of Pharmacy, School of Medicine. Since his appointment as a lecturer in December 2009, Dr Patel has made a significant contribution in learning and teaching at both under- and post-graduate level. Apart from receiving two teaching merit certificates and exceptional feedback from the under-graduate and post-graduate students, Dr Patel has thoughtfully re-structured the Master of Pharmaceutical Science (MPharmSc) course to ensure a broader career and scholarly prospective for the graduates of this course. Dr Patel's research has resulted in a significant practice change in professional/clinical practice and also assisted a number of healthcare professionals in the area of pharmaceutical formulations. Dr Patel has actively participated in marketing of the MPharmSc course at National and International level resulting in almost a 100% increase in the student numbers. Dr Patel has also actively looked for quality graduate research students within the last one and half years of his appointment as a Graduate Research Coordinator as seen by the marked increase in the number of good quality Higher Degree Research applicants.

Career summary

Qualifications

  • PhD, University of Tasmania, Australia, 2008. Thesis: Enoxaparin: physicochemical investigations into the effects of freezing and heating
  • MPharmSc, University of Tasmania, Australia, 2005. Thesis: Assessment of stability and activity of enoxaparin sodium by capillary electrophoresis
  • Bachelor of Pharmacy, Rajiv Gandhi University of Health Sciences, India. 2002

Languages (other than English)

Hindi, Gujarati

Biography

Dr Patel completed his Bachelor of Pharmacy degree from the Rajiv Gandhi University of Health Sciences, India. Before migrating to Australia, he worked as an Analytical Chemist at Elite Pharmaceuticals, India. Dr Patel obtained his Master of Pharmaceutical Science and PhD degrees from the University of Tasmania. After completion of his PhD in 2008, he worked as a registered pharmacist in Queensland, Australia. Dr Patel joined the Division of Pharmacy, School of Medicine as a lecturer in Pharmacological Sciences in December 2009.

Research Themes

Dr Patel's research aligns to the University's research theme of Better Health. His research interests include:

  • Development of novel chromatographic techniques for the structure-activity characterisation of a group of glycosaminoglycans such heparins and fucoidans. Glycosaminoglycans are composed of heterogeneous mixture of highly negatively charged structurally complicated molecules. Using sophisticated analytical, in-vitro, ex-vivo and in-vivo techniques, Dr Patel and his colleagues identified novel glycosaminoglycan molecules having anti-asthmatic and anti-ulcerative colitis potential. Dr Patel and his group has developed a number of novel and robust analytical techniques that could be used to separate and identify structurally unknown molecules of glycosaminoglycans. For example, Dr Patel and his group developed a simple and sensitive method, for the analysis of batch-to-batch variation in pharmaceutical heparins. In December 2007, an increase in the number of adverse events including deaths were reported resulting from the use of contaminated batches of heparin. To ensure safety, the US Food and Drug Administration developed a reference test method, based on the method developed by Dr Patel and his group. All Pharmaceutical companies were instructed to use this reference method to detect impurities in all heparin batches to manufacture and enter the United States.
  •  Investigating the physico-chemical stability of extemporaneously prepared pharmaceutical formulations. Dr Patel has investigated the stability of a wide range of extemporaneous preparations and his research has contributed to the field of science and health.  For example, the stability of one type of carbohydrate (iron polymaltose) formulation commonly used for severe iron-deficiency anaemia was unknown beyond 24 hours and therefore such preparations were traditionally prepared by Australian hospital pharmacists on a daily basis, resulting in subsequent workload and costs. Dr Patel's recent research indicated that the stability of such preparations can be safely extended from 24 hours to 28 days, and hence it is possible to prepare them in advance rather than on a daily basis. This finding has significantly reduced the workload of Australian hospital pharmacists as this formulation, based on his research finding, is now prepared commercially by Baxter Healthcare with an expiry date of 28 days. Also, Dr Patel has recently indicated that various types of antibiotics, when stored appropriately, are stable in different types of dialysis solutions. Such antibiotics premixed solutions can be prepared in advance by nurses and given to the patients. Therefore, patients can be treated at home rather than in the hospital. These findings have changed the current clinical practice as evident from the fact that based on his published research; the Royal Hobart Hospital has updated their guidelines for the preparation and storage of antibiotics in dialysis solutions.
  • Minimising the particle and microbial associated harm among injecting drug users (IDU). Oral prescription opioids (morphine, oxycodone, buprenorphine) are not always administered the way they are intended. The way IDU prepare injecting solutions from prescription opioids make them susceptible to particle- and microbial- related harm (thrombosis, amputation, pulmonary embolism, skin infection, endocarditis etc.). Dr Patel and his colleagues are working on developing various techniques that can minimise the risk of particle and microbial related harm among IDU.

Memberships

Professional practice

  • Pharmaceutical Society of Australia

Administrative expertise

  • Master of Pharmaceutical Science Course Coordinator
  • Graduate Diploma of Pharmaceutical Science Course Coordinator
  • Graduate Research Coordinator
  • Established and manages the Pharmacy Division's chromatography laboratory
  • A member of Division of Pharmacy Executive committee

Teaching

Infectious Disease, Medicinal Chemistry, Drug Development, Chromatography, Physiochemical Stability

Teaching expertise

Teaching philosophy: Dr Patel's teaching philosophy involves problem-based learning. Generally, each lecture starts with individual examples or problems, through the consideration of which students develop general principles and basic concepts. Dr Patel often incorporate humour in every lecture to foster student-lecturer relationship and to motivate students to learn. He believes in 'active learning' or 'class room participation'; hence, he tries to get everyone involved by posing various questions and also initiate feedback from students during lectures. It creates an environment in which all participants have the opportunity to learn and students explore issues and ideas in depth, from a variety of viewpoints.

Changes to Master of Pharmaceutical Science (MPharmSc) course structure: Dr Patel has been coordinating the MPharmSc course since July 2012. In his capacity as a course coordinator, Dr Patel has made significant changes to the course structure, including changing the course duration from one to two years. The changes were greatly accepted by the students, evident from students' feedback as well as significant increase in the number of MPharmSc students.

Scholarly Teaching: Dr Patel has been involved in a number of learning and teaching related scholarship activities. These include: 1) submission of an 'Expression of Interest' for teaching development grants (University of Tasmania; category (A); 2) completion of a project that investigated the barriers among pharmacy academics with regards to the use of Facebook as a teaching tool; and 3) completion of a project that evaluated the attitudes of post graduate students towards evidence based medicine.

Teaching responsibility

Dr Patel coordinates both the Master of Pharmaceutical Science and Graduate Diploma in Pharmaceutical Science course. He teaches into several units within the Bachelor of Pharmacy, Master of Pharmaceutical Science and Diploma in Pharmaceutical Science course programs. 

Research Appointments

In addition to reviewing scientific manuscripts for a number international journals (Chromatographic Science, Natures Protocols, Current Drug Safety, Journal of Clinical Pharmacy and Therapeutics), Dr Patel is on the editorial panel of the Journal of Paediatric Biochemistry, and the International Journal of Applied Biology and Pharmaceutical Technology.

Research Invitations

Dr Patel has presented his research at National and International forums. In 2010, he chaired a conference session at the International Conference on Analytical and Bioanalytical Techniques: Pharmaceutical R & D Summit (Hyderabad, India).

View more on Dr Rahul Patel in WARP

Expertise

  • Chromatographic techniques
  • Physico-chemical characterisation of pharmaceutical and nutraceutical products
  • Investigating novel biological activities of carbohydrates
  • Pharmacokinetic studiesHarm minimisation

Collaboration

On a number of research projects, Dr Patel has collaborated with clinicians from the Royal Hobart Hospital, researchers from Australian Centre for Research on Separation Science (FSET), Centre of Research Excellence for Chronic Respiratory Disease, School of Human Life Sciences and division of Psychology, School of Medicine. Dr Patel has collaborated with a local Biotechnology company (Marinova Pty. Ltd) on a number of research projects. These collaborations have resulted in multiple joint publications.

Current projects

  1. Structure-activity characterisation of complicated glycosaminoglycans
  2. Non-anticoagulant derivatives of heparins for the management of inflammatory conditions
  3. Investigation of oral bioavailability and plasma pharmacokinetics of carbohydrates
  4. Minimising particle and microbial associated harm among injecting drug users
  5. Physico-chemical stability of various pharmaceutical dosage forms

Research Fields

  • Pharmaceutical Sciences (111504)
  • Clinical Pharmacy and Pharmacy Practice (111503)
  • Pharmacology and Pharmaceutical Sciences (111599)
  • Nephrology and Urology (110312)
  • Infectious Diseases (110309)
  • Respiratory Diseases (110203)
  • Clinical Pharmacology and Therapeutics (111502)
  • Basic Pharmacology (111501)
  • Health, Clinical and Counselling Psychology (170106)
  • Public Health and Health Services (111799)
  • Technology (109999)
  • Preventive Medicine (111716)
  • Separation Science (030108)
  • Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) (170101)
  • Medical and Health Sciences (119999)
  • Rheumatology and Arthritis (110322)
  • Analytical Biochemistry (060101)
  • Cellular Immunology (110704)
  • Primary Health Care (111717)
  • Traditional Chinese Medicine and Treatments (110404)
  • Biologically Active Molecules (030401)
  • Central Nervous System (110903)
  • Clinical Social Work Practice (160701)
  • Health Promotion (111712)
  • Medical Bacteriology (110801)

Research Impact

  • Public Health (excl. Specific Population Health) (920499)
  • Health (929999)
  • Urogenital System and Disorders (920119)
  • Digestive System Disorders (920105)
  • Substance Abuse (920414)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Infectious Diseases (920109)
  • Clinical Health (Organs, Diseases and Abnormal Conditions) (920199)
  • Respiratory System and Diseases (incl. Asthma) (920115)
  • Health Related to Ageing (920502)
  • Immune System and Allergy (920108)
  • Blood Disorders (920101)
  • Health Policy Evaluation (920208)
  • Expanding Knowledge in Technology (970110)
  • Diabetes (920104)
  • Human Biological Preventatives (e.g. Vaccines) (860801)
  • Skeletal System and Disorders (incl. Arthritis) (920116)
  • Mental Health Services (920209)
  • Veterinary Pharmaceutical Products (860999)
  • Nervous System and Disorders (920111)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Hearing, Vision, Speech and Their Disorders (920107)
  • Injury Control (920409)
  • Evaluation of Health Outcomes (920204)
  • Health Education and Promotion (920205)
  • Health and Support Services (920299)
  • Preventive Medicine (920412)

Publications

Dr Patel's research work is published in peer reviewed journals, such as Integrative Biology, Analytical and Bioanalytical Chemistry, Plos One, Journal of Pharmaceutical Science, as well as in more specialised journals such as Expert Opinion on Investigational Drugs, Peritoneal Dialysis International and American Journal of Health System Pharmacy.

Total publications

40

Journal Article

(28 outputs)
YearCitationAltmetrics
2016Sultana K, Al Jeraisy M, Al Ammari M, Patel RP, Zaidi ST, 'Attitude, barriers and facilitators to practice-based research: cross-sectional survey of hospital pharmacists in Saudi Arabia', Journal of pharmaceutical policy and practice ISSN 2052-3211 (2016) [Refereed Article]

DOI: 10.1186/s40545-016-0052-z [eCite] [Details]

Co-authors: Zaidi ST

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2016Yousaf F, Razi Zaidi ST, Wanandy Troy, Jose MD, Patel RP, 'Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags', Peritoneal Dialysis International, 36, (4) pp. 457-459. ISSN 0896-8608 (2016) [Contribution to Refereed Journal]

DOI: 10.3747/pdi.2015.00169 [eCite] [Details]

Co-authors: Razi Zaidi ST; Wanandy Troy; Jose MD

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2015Lean QY, Eri RD, Fitton JH, Patel RP, Gueven N, 'Fucoidan extracts ameliorate acute colitis', PLoS One, 10, (6) Article e0128453. ISSN 1932-6203 (2015) [Refereed Article]

DOI: 10.1371/journal.pone.0128453 [eCite] [Details]

Citations: Scopus - 6Web of Science - 4

Co-authors: Lean QY; Eri RD; Gueven N

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2015Lean QY, Eri RD, Randall-Demllo S, Sohal SS, Stewart N, et al., 'Orally Administered Enoxaparin Ameliorates Acute Colitis by Reducing Macrophage-Associated Inflammatory Responses', PLoS One, 10, (7) Article e0134259. ISSN 1932-6203 (2015) [Refereed Article]

DOI: 10.1371/journal.pone.0134259 [eCite] [Details]

Citations: Scopus - 2Web of Science - 3

Co-authors: Lean QY; Eri RD; Randall-Demllo S; Sohal SS; Stewart N; Peterson GM

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2015Lean QY, Gueven N, Eri RD, Bhatia R, Sohal SS, et al., 'Heparins in ulcerative colitis: proposed and potential reasons for inconsistent clinical outcomes', Expert Review of Clinical Pharmacology, 8, (6) pp. 795-811. ISSN 1751-2433 (2015) [Refereed Article]

DOI: 10.1586/17512433.2015.1082425 [eCite] [Details]

Co-authors: Lean QY; Gueven N; Eri RD; Sohal SS; Stewart N; Peterson GM

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2015Lu W, Ferguson SG, Nichols D, Patel R, Jacobson GA, 'Determination of nicotine in cartridge-based electronic cigarettes', Analytical Letters, 48, (17) pp. 2715-2722. ISSN 0003-2719 (2015) [Refereed Article]

DOI: 10.1080/00032719.2015.1048349 [eCite] [Details]

Co-authors: Lu W; Ferguson SG; Nichols D; Jacobson GA

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2015Ng H, Patel RP, Bruno R, Latham R, Wanandy T, et al., 'Filtration of crushed tablet suspensions has potential to reduce infection incidence in people who inject drugs', Drug and Alcohol Review, 34, (1) pp. 67-73. ISSN 0959-5236 (2015) [Refereed Article]

DOI: 10.1111/dar.12196 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Ng H; Bruno R; Latham R; Wanandy T; McLean S

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2015Patel RP, Li K, Shastri M, Wanandy T, 'Stability of ampicillin and amoxicillin in peritoneal dialysis solutions', American Journal of Health-System Pharmacy, 72 pp. 13-14. ISSN 1079-2082 (2015) [Letter or Note in Journal]

DOI: 10.2146/ajhp130717 [eCite] [Details]

Citations: Scopus - 1

Co-authors: Li K; Shastri M; Wanandy T

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2015Patel RP, Li K, Shastri M, Wanandy T, Jose MD, 'Stability of ampicillin and amoxicillin in peritoneal dialysis solutions', American Journal of Health-System Pharmacy, 72 pp. 13-14. ISSN 1695-0674 (2015) [Letter or Note in Journal]

DOI: 10.2146/ajhp130717 [eCite] [Details]

Citations: Scopus - 1

Co-authors: Shastri M; Jose MD

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2015Patel RP, Wanandy T, Zani RS, Jose MD, Shastri M, et al., 'Stability of trimethoprim in newly formulated liquid dosage form', Journal of Pharmacy Practice and Research, 45, (1) pp. 10-14. ISSN 1445-937X (2015) [Refereed Article]

DOI: 10.1002/jppr.1127 [eCite] [Details]

Co-authors: Wanandy T; Shastri M; Zaidi STR

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2015Ramdas S, Yousaf F, Shastri MD, Wanandy T, Zaidi STR, et al., 'Stability of daptomycin in peritoneal dialysis solutions packaged in dual-compartment infusion bags', European Journal of Hospital Pharmacy pp. 1-4. ISSN 2047-9956 (2015) [Refereed Article]

DOI: 10.1136/ejhpharm-2015-000651 [eCite] [Details]

Co-authors: Ramdas S; Shastri MD; Wanandy T; Zaidi STR; Khandagale M; Jose M

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2015Robiyanto R, Zaidi STR, Shastri MD, Castelino RL, Wanandy T, et al., 'Stability of tigecycline in different types of peritoneal dialysis solutions', Peritoneal Dialysis International pp. 1-5. ISSN 0896-8608 (2015) [Refereed Article]

DOI: 10.3747/pdi.2015.00170 [eCite] [Details]

Co-authors: Zaidi STR; Shastri MD; Castelino RL; Wanandy T; Jose MD

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2015Shastri MD, Stewart N, Eapen M, Peterson GM, Zaidi STR, et al., 'Opposing effects of low molecular weight heparins on the release of inflammatory cytokines from peripheral blood mononuclear cells of asthmatics', PLoS One, 10, (3) Article e0118798. ISSN 1932-6203 (2015) [Refereed Article]

DOI: 10.1371/journal.pone.0118798 [eCite] [Details]

Citations: Scopus - 2Web of Science - 3

Co-authors: Shastri MD; Stewart N; Eapen M; Peterson GM; Zaidi STR; Guven N; Sohal SS

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2015Shastri MD, Stewart N, Horne J, Peterson GM, Gueven N, et al., 'In-vitro suppression of IL-6 and IL-8 release from human pulmonary epithelial cells by non-anticoagulant fraction of enoxaparin', PLoS One, 10, (5) Article e0126763. ISSN 1932-6203 (2015) [Refereed Article]

DOI: 10.1371/journal.pone.0126763 [eCite] [Details]

Co-authors: Shastri MD; Stewart N; Horne J; Peterson GM; Gueven N; Sohal SS

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2015Shastri MD, Stewart N, Horne J, Zaidi STR, Sohal SS, et al., 'Non-anticoagulant fractions of enoxaparin suppress inflammatory cytokine release from peripheral blood mononuclear cells of allergic asthmatic individuals', PLoS One, 10, (6) Article e0128803. ISSN 1932-6203 (2015) [Refereed Article]

DOI: 10.1371/journal.pone.0128803 [eCite] [Details]

Citations: Scopus - 1Web of Science - 2

Co-authors: Shastri MD; Stewart N; Horne J; Zaidi STR; Sohal SS; Peterson GM; Korner H; Gueven N

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2014Lean QY, Patel RP, Stewart N, Sohal SS, Guven N, 'Identification of pro-and anti-proliferative oligosaccharides of heparins', Integrative Biology, 6, (1) pp. 90 - 99. ISSN 0974-2816 (2014) [Refereed Article]

DOI: 10.1039/c3ib40206a [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Lean QY; Stewart N; Sohal SS; Guven N

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2014Patel RP, Shastri MD, Bakkari M, Wanandy T, Jose MD, 'Stability of the combination of ceftazidime and cephazolin in icodextrin or pH neutral peritoneal dialysis solution', Peritoneal Dialysis International, 34, (2) pp. 212-218. ISSN 0896-8608 (2014) [Refereed Article]

DOI: 10.3747/pdi.2013.00034 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Shastri MD; Wanandy T; Jose MD

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2014Shastri M, Peterson GM, Stewart NJ, Sohal SS, Patel RP, 'Non-anticoagulant derivatives of heparin for the management of asthma: distant dream or close reality?', Expert Opinion on Investigational Drugs: Authoritative Analysis of Randd Trends, 23, (3) pp. 357-373. ISSN 1354-3784 (2014) [Refereed Article]

DOI: 10.1517/13543784.2014.866092 [eCite] [Details]

Citations: Scopus - 7Web of Science - 7

Co-authors: Shastri M; Peterson GM; Stewart NJ; Sohal SS

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2014Nowrin K, Sohal SS, Peterson G, Patel R, Walters EH, 'Epithelial-mesenchymal transition as a fundamental underlying pathogenic process in COPD airways: fibrosis, remodeling and cancer', Expert Reviews in Respiratory Medicine, 8, (5) pp. 547-559. ISSN 1747-6348 (2014) [Refereed Article]

DOI: 10.1586/17476348.2014.948853 [eCite] [Details]

Citations: Scopus - 11Web of Science - 9

Co-authors: Nowrin K; Sohal SS; Peterson G; Walters EH

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2013Patel RP, Shastri M, Wanandy ST, Jose MD, 'Physical and chemical stability of ceftazidime and cefazolin in peritoneal dialysis solutions packaged in dual-chamber infusion bags', American Journal of Health-System Pharmacy, 70, (17) pp. 1477-1478. ISSN 1079-2082 (2013) [Letter or Note in Journal]

DOI: 10.2146/ajhp120692 [eCite] [Details]

Co-authors: Shastri M; Wanandy ST; Jose MD

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2013Patel RP, Wanandy S, Loring S, Johns C, Hutchinson J, et al., 'Stability of diluted iron polymaltose in PVC infusion bags', Journal of Pharmacy Practice and Research, 43, (2) pp. 112-116. ISSN 1445-937X (2013) [Refereed Article]

[eCite] [Details]

Co-authors: Wanandy S; Johns C; Hutchinson J; Shastri M

2013Shastri MD, Johns C, Hutchinson JP, Khandagale M, Patel RP, 'Ion exchange chromatographic separation and isolation of oligosaccharides of intact low-molecular-weight heparin for the determination of their anticoagulant and anti-inflammatory properties', Analytical and Bioanalytical Chemistry, 405, (18) pp. 6043-6052. ISSN 1618-2650 (2013) [Refereed Article]

DOI: 10.1007/s00216-013-6996-9 [eCite] [Details]

Citations: Scopus - 8Web of Science - 9

Co-authors: Shastri MD; Johns C; Hutchinson JP; Khandagale M

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2012Patel PK, Patel RP, Brandon S, McLean S, Bruno R, et al., 'Effects of Filtration on the Presence of Particulate and Oxycodone Content of Injections Prepared from Crushed OxyContin® Tablets', Current Drug Safety, 7, (3) pp. 218-224. ISSN 1574-8863 (2012) [Refereed Article]

DOI: 10.2174/157488612803251298 [eCite] [Details]

Citations: Scopus - 5

Co-authors: Brandon S; McLean S; Bruno R; de Graaff B

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2009Patel R, Narkowicz CK, Jacobson GA, 'Investigation of the effect of heating on the chemistry and antifactor Xa activity of enoxaparin', Journal of Pharmaceutical Science, 98, (5) pp. 1700 - 1711. ISSN 0022-3549 (2009) [Refereed Article]

DOI: 10.1002/jps.21556 [eCite] [Details]

Citations: Scopus - 9Web of Science - 8

Co-authors: Narkowicz CK; Jacobson GA

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2009Patel R, Narkowicz CK, Jacobson GA, 'Investigation of freezing- and thawing-induced biological, chemical, and physical changes to enoxaparin solution', Journal of Pharmaceutical Science, 98, (3) pp. 1118 - 1128. ISSN 0022-3549 (2009) [Refereed Article]

DOI: 10.1002/jps.21483 [eCite] [Details]

Citations: Scopus - 7Web of Science - 8

Co-authors: Narkowicz CK; Jacobson GA

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2009Patel R, Narkowicz CK, Jacobson GA, 'Effective reversed-phase ion pair high-performance liquid chromatography method for the separation and characterization of intact low-molecular-weight heparins ', Analytical Biochemistry, 387, (1) pp. 113-121. ISSN 0003-2697 (2009) [Refereed Article]

DOI: 10.1016/j.ab.2009.01.007 [eCite] [Details]

Citations: Scopus - 21Web of Science - 21

Co-authors: Narkowicz CK; Jacobson GA

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2008Patel R, Narkowicz CK, Hutchinson J, Hilder EF, Jacobson GA, 'A simple capillary electrophoresis method for the rapid separation and determination of intact low molecular weight and unfractionated heparins', Journal of Pharmaceutical and Biomedical Analysis, 46, (1) pp. 30-35. ISSN 0731-7085 (2008) [Refereed Article]

DOI: 10.1016/j.jpba.2007.10.009 [eCite] [Details]

Citations: Scopus - 52Web of Science - 44

Co-authors: Narkowicz CK; Hutchinson J; Hilder EF; Jacobson GA

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2008Patel R, Narkowicz CK, Jacobson GA, 'In vitro stability of enoxaparin solutions (20 mg/mL) diluted in 4% glucose', Clinical Therapeutics, 30, (10) pp. 1880-1885. ISSN 0149-2918 (2008) [Refereed Article]

DOI: 10.1016/j.clinthera.2008.10.014 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Narkowicz CK; Jacobson GA

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Chapter in Book

(3 outputs)
YearCitationAltmetrics
2016Dimond R, Patel RP, Zaidi STR, 'Fluoroquinolones', Drug Dosing in Obesity - Volume 1: Antimicrobials, Springer International Publishing, STR Zaidi & JA Roberts (ed), Switzerland ISBN 978-3-319-44034-7 (2016) [Research Book Chapter]

DOI: 10.1007/978-3-319-44034-7 [eCite] [Details]

Co-authors: Zaidi STR

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2016Lean QY, Gueven N, Eri RD, Peterson GM, Patel RP, 'Non-Anticoagulant Oligosaccharides of Enoxaparin Relieve Chemical-Induced Acute Colitis', Advances in Medicine and Biology, Nova Science Publishers, LV Berhardt (ed), United States, pp. 87-104. ISBN 978-1-63483-988-4 (2016) [Research Book Chapter]

[eCite] [Details]

Co-authors: Lean QY; Gueven N; Eri RD; Peterson GM

2016Van Dyk E, Patel RP, Razi Zaidi ST, 'Miscellaneous agents', Drug Dosing in Obesity - Volume 1: Antimicrobials, Springer International Publishing, STR Zaidi & JA Roberts (ed), Switzerland ISBN 978-3-319-44034-7 (2016) [Research Book Chapter]

DOI: 10.1007/978-3-319-44034-7 [eCite] [Details]

Co-authors: Razi Zaidi ST

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Conference Publication

(8 outputs)
YearCitationAltmetrics
2011Patel P, Patel RP, McLean SR, Bruno RB, 'Effects of Filtration on the Presence of Particulate and Buprenorphine Content of Injections Prepared from Crushed Subutex® Tablets', Drug and Alcohol Review, 13-16 November 2011, Hobart, Australia, pp. 72. ISSN 0959-5236 (2011) [Conference Extract]

[eCite] [Details]

Co-authors: McLean SR; Bruno RB

2010McLean SR, Brandon S, Bruno RB, de Graaff B, Patel RP, 'Reducing harm from pharmaceutical opioid injection: The importance and effectiveness of filters', Drug and Alcohol Review, 28 November -1 December 2010, Canberra, Australia, pp. A51. (2010) [Conference Extract]

[eCite] [Details]

Co-authors: McLean SR; Brandon S; Bruno RB; de Graaff B

2010McLean SR, Brandon S, de Graaff B, Bruno RB, Patel RP, 'Injecting OxyContin: What is the harm reduction eveidence?', Proceedings of ATDC 2010, 18-20 October 2010, Hobart, pp. 1. (2010) [Conference Extract]

[eCite] [Details]

Co-authors: McLean SR; Brandon S; de Graaff B; Bruno RB

2009Patel RP, Narkowicz CK, Jacobson GA, 'A low-volume microtitre plate assay for determination of the AFXa activity of enoxaparin', Australasian Pharmaceutical Science Association Annual Conference Aus-CRS Symposium Program and Abstract book, 9-11 December 2009, Wrest Point Convention Centre, Hobart Tasmania, pp. 140. ISBN 978-0-646-52257-9 (2009) [Conference Extract]

[eCite] [Details]

Co-authors: Narkowicz CK; Jacobson GA

2008Patel R, 'Stability enhancement ofl diluted enoxaparin sodium at paediatric dosage', Teams for tomorrow, 6-9 December 2008, Canberra, ACT, pp. 108. (2008) [Conference Extract]

[eCite] [Details]

2007Patel R, Narkowicz CK, Jacobson GA, 'The effect of heating on the chemistry and biological activity of enoxaparin', Australian Pharmaceutical Science Association, 8-11 December 2007, Manly NSW, pp. 205. ISBN 978-0-646-48458-7 (2007) [Conference Edited]

[eCite] [Details]

Co-authors: Narkowicz CK; Jacobson GA

2007Patel R, Narkowicz CK, Jacobson GA, 'The effects of freezing and thawing on the AFXa activity of enoxaparin solution', Australian Pharmaceutical Science Association, 8-11 December 2007, Manly NSW, pp. 205. ISBN 978-0-646-48458-7 (2007) [Conference Edited]

[eCite] [Details]

Co-authors: Narkowicz CK; Jacobson GA

2007Patel R, Narkowicz CK, Jacobson GA, 'Separation and characterisation of different low-molecular-weight heparins by reversed-phase ion-interaction high-performance liquid chromatography', Proceedings of the APSA Annual Conference, 8-11 December 2007, Manly NSW, pp. 205. ISBN 978-0-646-48458-7 (2007) [Conference Extract]

[eCite] [Details]

Co-authors: Narkowicz CK; Jacobson GA

Thesis

(1 outputs)
YearCitationAltmetrics
2007Patel R, 'Enoxaparin: physicochemical investigations into the effects of freezing and heating' (2007) [PhD]

[eCite] [Details]

Grants & Funding

Dr Patel's research projects have been funded by the University of Tasmania, Faculty of Health (University of Tasmania), Royal Hobart Hospital Research Foundation and Marinova Pty Ltd (an Australian biotechnology company specialising in manufacturing carbohydrate extracts). Dr Patel has a proven record in successfully achieving project goals. For example, Dr Patel successfully completed the projects funded in 2011, 2013 and 2014 by the Royal Hobart Hospital Research Foundation. Data generated from those projects led to eight peer reviewed publications and two conference publications.

Funding Summary

Number of grants

15

Total funding

$341,342

Projects

Investigating the physical and chemical Y-site incompatibility of injectable antifungals and parenteral nutrition solution (2016)$9,795
Funding
Royal Hobart Hospital Research Foundation ($9,795)
Scheme
Grant-Starter
Administered By
University of Tasmania
Research Team
Wanandy ST; Patel RP; Razi Zaidi ST; Anderson T; Castelino RL
Year
2016
Fucoidan and stem cell mobilisation (2015)$54,095
Description
Industry interaction to test if Marinova's fucoidan extracts mobilise stem cells.
Funding
Marinova Pty Ltd ($54,095)
Scheme
Clinical Trial
Administered By
University of Tasmania
Research Team
Guven N; Eri RD; Ahuja KDK; Patel RP
Year
2015
Fucoidan and gut health (2015)$100,000
Description
This project represents industry interaction to develop Marinovas fucoidan extract for gut health.
Funding
Department of Industry and Science ($50,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Guven N; Davis E; Eri RD; Patel RP
Year
2015
Non anticoagulant molecules of heparin for the management of ulcerative colitis (2015)$15,000
Description
This project aims to achieve the identification and evaluation of non-anticoagulant molecules of heparin that are responsible for the observed beneficial effects of heparin in patients with ulcerative colitis as well as to compare potential biomarkers in a preclinical muse model with ulcerative colitis patients.
Funding
Royal Hobart Hospital Research Foundation ($15,000)
Scheme
Grant-Clinical Research
Administered By
University of Tasmania
Research Team
Patel RP; Guven N; Eri RD; Bhatia R
Year
2015
Novel molecules of heparin for the management of asthma (2015)$10,000
Description
We will isolate immune cells from persons with asthma and treat them in vitro with heparin fractions to determine their effects on the immune system.
Funding
Royal Hobart Hospital Research Foundation ($10,000)
Scheme
Grant-Clinical Research
Administered By
University of Tasmania
Research Team
Patel RP; Shastri M; Wanandy ST
Year
2015
Novel molecules of heparin for the management of asthma (2014)$4,998
Description
Aim: In an international first, this project aims to achieve the evaluation and identification of heparin molecules that inhibit the effect of several important inflammatory mediators involved in the pathogenesis of asthma, without possessing significant anticoagulant effect, with a view towards examining the efficacy of identified molecules in patients with asthma. Methodology: Heparin molecules will be separated and isolated using an ion-chromatography technique. Participants will attend the clinic where 50mL of blood will be taken by a qualified nurse. Mononuclear cells will be isolated from the collected blood. Then the cells will be activated to produce inflammatory mediators in the presence or absence of heparin fractions. Outcome: This research will evaluate and identify the novel molecules responsible for the anti-asthmatic activity of the parent heparin. This study would provide better insight into the mechanism(s) of heparin for its anti-asthmatic activity. It could open new avenues for the development of a heparin formulation with high anti-asthmatic properties but devoid of any anticoagulant activity. This could potentially resolve the safety and non-compliance issues objected upon in previous clinical trials.
Funding
Royal Hobart Hospital Research Foundation ($4,998)
Scheme
Grant-Starter
Administered By
University of Tasmania
Research Team
Hunter CJ; Patel RP; Stewart NJ; Sohal SS
Year
2014
Novel Fractions of Heparin for the Treatment of Ulcerative Colitis (2014)$14,500
Funding
University of Tasmania ($14,500)
Scheme
Grant-Research Enhancement (REGS)
Administered By
University of Tasmania
Research Team
Patel RP
Year
2014
Fucoidan extract in the treatment of ulcerative colitis in an animal model (2013)$2,810
Description
Brown algal extracts, in particular those containing fucoidan have been shown to have potential applications in a number of health indications such as prediabetes, immunomodulation, cardiovascular disease, inflammation and gut health. With advances in technology, fucoidan extracts from brown seaweed can now be produced successfully on a commercial scale. These types of extracts are beginning to become more prevalent as ingredients in western dietary supplement markets. However, for the extracts to successfully enter this market, efficacy, safety and provenance must be proven to help gain acceptance. With this in mind, the objectives of this project include the following: to establish the efficacy of high purity fucoidan extract from Fucusvesiculosus in the treatment of ulcerative colitis in an animal model; and to compare the efficacy of the routes of administration of Fucusvesiculosus fucoidan in treating ulcerative colitis with particular reference to oral and intra-peritoneal dosages.
Funding
Marinova Pty Ltd ($2,810)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Peterson GM; Guven N; Patel RP
Year
2013
The physical and chemical stability of amoxicillin, daptomycin and quinupristin/dalfopristin in Dianeal, Extraneal or Fresenius peritonieal dialysis solution under three different storage conditions (2013)$9,090
Description
The physicochemical stability of amoxicillin, daptomycin and quinupristin/dalfopristin in peritoneal dialysis solution is currently unknown. This study will determine the stability of these antibiotics in various types of PD solutions and will supply crucial information to guide current clinical practice and to provide a more convenient service for patients with end stage renal disease.
Funding
Royal Hobart Hospital Research Foundation ($9,090)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Wanandy ST; Patel RP; Jose MD
Year
2013
Fucoidan and marine polyphloroglucinols (2012 - 2014)$85,000
Description
Brown algal extracts, in particular those containing fucoidan and marine polyphloroglucinols, have been shown to have potential applications in a number of health indications such as pre-diabetes, immunomodulation, cardiovascular disease and inflammation. With advances in technology, fucoidan and marine polyphloroglucinol extracts from brown seaweed can now be produced successfully on a commercial scale. These types of extracts are beginning to become more prevalent as ingredients in western dietary supplement markets. However, for the extracts to successfully enter this market, efficacy, safety and provenance must be proven. With this in mind, the objectives of this PhD project include the following: to establish a generic analytical method that can be used to fingerprint and quantify fucoidan concentrations in solution, serum and urine; to determine the ability of a commercially available fucoidan/polyphloroglucinol extract (Maritech Synergy) to inhibit the uptake of glucose via an acute human study; to assess the effects of Maritech Synergy on health indications including glucose control, insulin sensitivity and pre-diabetes in a human setting; and to further the understanding of fucoidan and its metabolism.
Funding
Marinova Pty Ltd ($85,000)
Scheme
Clinical Trial
Administered By
University of Tasmania
Research Team
Peterson GM; Patel RP; Bereznicki LRE
Period
2012 - 2014
Identification and Screening of Heparin components for therapeutical Potential in the management of Asthma (2011)$16,218
Funding
University of Tasmania ($16,218)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Patel RP
Year
2011
Development of a Simple and Effective Ion-chromatagraphic Analysis for the Separation and Identification of Non-anticoagulant fractions of Enoxaparin (2011)$6,950
Funding
University of Tasmania ($6,950)
Scheme
Grant-Cross Theme
Administered By
University of Tasmania
Research Team
Patel RP; Hutchinson J; Johns CA; Jacobson GA; Narkowicz CK; Peterson GM
Year
2011
Investigations of the Chemical and Physical Stability of Iron Polymaltose Intravenous Infusion (2011)$6,364
Funding
Royal Hobart Hospital Research Foundation ($6,364)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Wanandy ST; Patel RP; Randall C; Jacobson GA; Holmes SE; Hutchinson C; Johns CA
Year
2011
Investigations into the Effect of Filtration on Drug Recovery, Particle and Bacterial Contents of Injections Prepared from Oxycodone or Buprenorphine Tablets (2010)$5,000
Funding
University of Tasmania ($5,000)
Scheme
Grant-New Appointees Research Grant Scheme (NARGS)
Administered By
University of Tasmania
Research Team
Patel RP
Year
2010
International Conference and Exhibition on Analytical and Bioanalytical Techniques - India, 2010 (2010)$1,522
Funding
University of Tasmania ($1,522)
Scheme
Grant-Conference Support Scheme
Administered By
University of Tasmania
Research Team
Patel RP
Year
2010

Research Supervision

Dr Patel currently supervise multiple PhD, Master of Pharmacy by Research, Master of Pharmaceutical Science and Honours students.

Current

4

Completed

4

Current

DegreeTitleCommenced
PhDThe Safety and Efficacy of Electronic-Cigarettes as Cessation Aids and the use of Electronic-Cigarettes by Smokers2013
MastersDevelopment, Validation and Application of an Analytical Method for the Determination of Fucose in Human Plasma2013
PhDInvestigation of Oral Bioavailability and Plasma Pharmacokinetics of Different Oral Formulations of Glucosamine2014
PhDTherapeutic Efficacy of Oligosaccharides of Novel Low Weight Heparin, Enoxaparin in Management of Asthma2015

Completed

DegreeTitleCompleted
PhDBioprocess Monitoring Using Sequential Injection Capillary Electrophoresis
Candidate: Ala Abdul Kareem Ahmad Alhusban
2016
PhDHeparins and Fucoidans: Future therapeutic options for ulcerative colitis
Candidate: Qi Ying Lean
2016
PhDNon-anticoagulant Derivatives of Heparin for the Management of Asthma: Distant dream or close reality?
Candidate: Madhur Shastri
2015
MastersDrivers of Epithelial-Mesenchymal Transition in Chronic Obstructive Pulmonary Disease
Candidate: Kaosia Nowrin
2015