Profiles

Lisa Foa

UTAS Home Assoc Prof Lisa Foa

Lisa Foa

Associate Head Research, School of Medicine
Head of Discipline, Biomedical Sciences
Faculty of Health

Room 414-22 (Level 4), Medical Science 1, Hobart CBD Campuses

+61 3 6226 2681 (phone)

+61 3 6226 2679 (fax)

Lisa.Foa@utas.edu.au

After conception our nervous system begins to grow. The complex circuitry of the brain begins to wire together in the embryo. Sometimes the nervous system doesn't develop normally and conditions like autism, schizophrenia and mental retardation can result. The nervous system is 'built' with molecules and proteins, and currently we don't know a lot about them. There are no effective drugs or therapies to treat nervous system disorders and no way to intervene with nervous system development.

Understanding nervous system development

Associate Professor Lisa Foa is trying to change that. She is a developmental neurobiologist studying how the circuitry of the brain begins to connect within the embryo.

'If we can understand the molecules and proteins that control nervous system development, and how they work normally, then we may be able to create drug and gene targets for conditions when the system is not working as it should,' said Associate Professor Foa.

'We may also be able to determine a way to regenerate a nervous system that has been damaged through trauma, like a car crash, or disease like diabetes.'

Associate Professor Foa's research has been instrumental in understanding how calcium signals affect nerve cell growth during nervous system development.

'Calcium governs communication between cells and signalling within cells. When information is sent through the nervous system, calcium passes that information along the line like a baton in a relay,' said Associate Professor Foa.

Her team is currently investigating how calcium is controlled within growing nerve cells and how this is important for nervous system development and function.

'Calcium is essential to a healthy nervous system. Without it nerves won't grow or function. If calcium levels are too low nerve cells shrivel and die, and if calcium levels are too high it becomes toxic and can kill cells. The latter is one hypothesis about Alzheimer's disease, that calcium is no longer regulated properly, and so calcium levels increase too much and cells begin to die. This means that our work has implications for the developing and ageing brain,' said Associate Professor Foa.

'We aim to discover which proteins regulate calcium and control it. We have discovered a couple of novel proteins that are important, but there are still so many proteins that we don't know anything about.'

Associate Professor Foa is particularly well known for her work on 'nerves growing in the dish'. She has been instrumental in building the neuroscience facilities in Tasmania, which have recently expanded to include zebrafish.

'The zebrafish nervous system functions the same way our nervous system does, using the same chemicals and nerve cells, except they are transparent. This allows the developing embryo and nervous system to be monitored in real time, in vivo.'

'Within the fish, we can make cells fluorescent with either dyes or genetics, and then we can watch those fluorescent cells develop within the active nervous system. Twenty-four hours after conception we can see the nerve cells in the spinal chord glow red or green.'

'Zebrafish have allowed us to take the work that we've done in the dish and see if it works in a real animal. We can manipulate the proteins and see what happens. We can see if the nervous system is developing normally.'

Tasmania's world-class facilities and team are attracting people from around the country and the globe to work here.

Career summary

Qualifications

  • PhD, Deakin University, Australia, 1996, thesis title: The ontogeny of putative GABAergic neurons and their receptors in the nervous system of the crayfish Cherax destructor
  • Graduate course: Neural Systems and Behavior, Marine Biological Laboratory, Woods Hole, MA, USA, 1992
  • B.Sc. (Hons), Deakin University, Australia, 1989

Biography

Lisa graduated from Deakin University with her PhD in 1996 and then spent 5 years in the US, working at the University of Michigan and then at the prestigious Cold Spring Harbor Laboratory in New York. While in the US, Lisa learnt a variety of in vivo and in vitro live cell imaging techniques that she now employs in her own laboratory at the University of Tasmania.

Lisa is now Associate Head Research for the School of Medicine and Head of the Biomedical Sciences Discipline for the Faculty of Health. She also teaches and coordinates a third year Neuroscience course in Bachelor of Medical Research, and carries an oversight role with the pre-clinical pharmacology teaching in the medical curriculum. Lisa supervises 3rd year research, honours and PhD students in her developmental neurobiology research laboratory.

Research Themes

Our research is aligned with the University's research theme of Better Health focusing on understanding how the complex circuitry of the brain is formed in the developing embryo. We are particularly interested in what we call 'axon pathfinding', where neurons extend processes, or axons, through the cellular milieu of the embryonic environment and connect with other neurons. Growing axons possess a highly dynamic navigational structure, known as a growth cone at their extending tips, and we know that growth cones are the cells' 'navigation' system.

But how do growth cones navigate? How do they find their targets during development? Answering these questions is important for us to understand developmental disorders such as autism and schizophrenia and in neurodegenerative disease such as Alzheimer's, where normal neural connectivity is lost. If we can understand how normal connections are made, we can discover new drug and gene targets for these significant disorders.

We know that calcium is crucial for growth cone navigation. Our research is focused on how calcium is controlled, so that we can decipher how calcium signals alter growth cone navigation. In our research, we use a combination of calcium imaging, optogenetics, live cell imaging in vitro and in vivo, and molecular biology.

We have a team of Postdocs, honours and PhD students, lead by Lisa and long-term collaborator, Dr Rob Gasperini, working on projects that cover four main areas:

1. How does calcium control growth cone navigation? We use two model systems to study growth cone navigation:

  • Live cell and calcium imaging of growth cones in vitro, and in collaboration with Dr John Lin (UTas) we use optogenetics to manipulate signaling in the growth cones
  • In collaboration with Dr Ethan Scott (UQ), we're using calcium imaging and genetic manipulation to study growth cone behavior in vivo within the zebrafish

2. Do glial cells move the same way growth cones do? We are using our models that we have for growth cones to study glial behavior in collaboration with Dr Kaylene Young (Menzies).

3. Can we use novel molecules or compounds to regulate growth cone navigation and axon regeneration after injury or disease? In collaboration with Emeritus Prof Adrian West and Prof Bruce Taylor (Menzies) we're studying axon regeneration in vivo after disease.

4. Our studies on calcium also relate to the ageing brain. In collaboration with Prof David Small (Menzies), we study the control of calcium in ageing, as one hypothesis on why neurons degenerate in Alzheimer's disease suggests calcium dysregulation.

Memberships

Other

  • 1997 – present - Society for Neuroscience (US)
  • 1990 – present - Australian Neuroscience Society

Teaching

Teaching expertise

Lisa has supervised a number of Honours and PhD students.  She currently supervises several PhD Students who are different stages of their candidature.

Teaching responsibility

Lisa teaches and coordinates Neuroscience. She also oversees Pharmacology teaching in Medicine.  In her neuroscience teaching, Lisa introduces students to current research in developmental neurobiology and learning and memory. Additionally she regularly runs third year students' research projects in her lab and also has Honours and PhD students who all work in Neuroscience research.

Units Taught

Research Appointments

  • 2015 – present - Elected Discipline Head, Biomedical Sciences, Faculty of Health
  • 2014 – present - Appointed to the Health Services Innovation Research Advisory committee
  • 2014 – present - Appointed Associate Head Research, School of Medicine
  • 2014 – present - Chair School of Medicine Research Committee
  • 2014 – present - Faculty of Health Research Committee
  • 2014 – present - Member of ERA3 (Health) cluster
  • 2014 – 2016 - Faculty Representative on University Graduate Research Complaints Panel
  • 2013 – 2014 - NHMRC Peer Review Honour Roll
  • 2013 – 2014 - NHMRC Peer Review Panel Member for Dora Lush PhD Scholarship applications
  • 2011 - Convenor Seminar Series for the Menzies Research Institute
  • 2010 - Chair NHMRC Peer Review Panel for Biomedical PhD Scholarship applications

View more on AssocProf Lisa Foa in WARP

Collaboration

  1. Dr Robert Gasperini, Menzies Institute for Medical Research 
  2. Professor David Small, Menzies Research Institute, University of Tasmania
  3. Dr Kaylene Young, Menzies Research Institute, University of Tasmania
  4. Professor Adrian West School of Medicine, University of Tasmania
  5. Professor Bruce Taylor, Menzies Research Institute, University of Tasmania
  6. Assoc Prof Jenny Rodger, University of Western Australia
  7. Dr John Chilton, University of Exeter, UK
  8. Dr Thomas Fath, University of New South Wales

Fields of Research

  • Cellular Nervous System (110902)
  • Neurosciences (110999)
  • Peripheral Nervous System (110905)
  • Central Nervous System (110903)
  • Neurology and Neuromuscular Diseases (110904)
  • Sensory Systems (110906)
  • Autonomic Nervous System (110901)
  • Cell Physiology (111601)
  • Systems Physiology (111603)
  • Epidemiology (111706)
  • Biochemistry and Cell Biology (060199)
  • Medicine, Nursing and Health Curriculum and Pedagogy (130209)
  • Ophthalmology (111301)
  • Proteins and Peptides (030406)
  • Nutrition and Dietetics (111199)
  • Environmental and Occupational Health and Safety (111705)
  • Basic Pharmacology (111501)
  • Nutritional Physiology (111103)
  • Signal Transduction (060111)
  • Pharmaceutical Sciences (111504)
  • Receptors and Membrane Biology (060110)
  • Foetal Development and Medicine (111401)
  • Cell Development, Proliferation and Death (060103)
  • Endocrinology (110306)
  • Medical Physiology (111699)
  • Innate Immunity (110707)
  • Cardiology (incl. Cardiovascular Diseases) (110201)

Research Objectives

  • Nervous System and Disorders (920111)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Expanding Knowledge in the Biological Sciences (970106)
  • Diabetes (920104)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Health Related to Ageing (920502)
  • Cardiovascular System and Diseases (920103)
  • Allied Health Therapies (excl. Mental Health Services) (920201)
  • Disease Distribution and Transmission (incl. Surveillance and Response) (920404)
  • Clinical Health (Organs, Diseases and Abnormal Conditions) (920199)
  • Hearing, Vision, Speech and Their Disorders (920107)
  • Cancer and Related Disorders (920102)
  • Behaviour and Health (920401)
  • Environmental Health (920405)
  • Inherited Diseases (incl. Gene Therapy) (920110)
  • Mental Health (920410)
  • Human Pharmaceutical Products (860899)
  • Infectious Diseases (920109)
  • Urban and Industrial Air Quality (960106)
  • Skin and Related Disorders (920117)

Publications

Total publications

54

Highlighted publications

(8 outputs)
YearTypeCitationAltmetrics
2012Chapter in BookGasperini RJ, Foa L, 'Methods in neuronal growth cone biology', TRP Channels in Drug Discovery. Methods in Pharmacology and Toxicology, Humana Press, T Biro & A Szallasi (ed), New York, pp. 239-252. ISBN 978-1-62703-094-6 (2012) [Research Book Chapter]

DOI: 10.1007/978-1-62703-095-3 [eCite] [Details]

Co-authors: Gasperini RJ

Tweet

2012Journal ArticleMitchell CB, Gasperini RJ, Small DH, Foa LC, 'STIM1 is necessary for store-operated calcium entry in turning growth cones', Journal of Neurochemistry, 122, (6) pp. 1155-66. ISSN 0022-3042 (2012) [Refereed Article]

DOI: 10.1111/j.1471-4159.2012.07840.x [eCite] [Details]

Citations: Scopus - 21Web of Science - 22

Co-authors: Gasperini RJ; Small DH

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2011Journal ArticleGasperini RJ, Hou X, Parkington H, Coleman H, Klaver DW, et al., 'TRPM8 and Nav 1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons', Molecular Neurodegeneration, 6, (19) pp. 1-12. ISSN 1750-1326 (2011) [Refereed Article]

DOI: 10.1186/1750-1326-6-19 [eCite] [Details]

Citations: Scopus - 9Web of Science - 7

Co-authors: Gasperini RJ; Klaver DW; Vincent AJ; Small DH

Tweet

2009Journal ArticleFoa LC, Gasperini RJ, 'Developmental roles for Homer: more than just a pretty scaffold', Journal of Neurochemistry, 108, (1) pp. 1-10. ISSN 0022-3042 (2009) [Refereed Article]

DOI: 10.1111/j.1471-4159.2008.05726.x [eCite] [Details]

Citations: Scopus - 26Web of Science - 23

Co-authors: Gasperini RJ

Tweet

2009Journal ArticleGasperini RJ, Choi-Lundberg DL, Thompson MJW, Mitchell CB, Foa LC, 'Homer regulates calcium signalling in growth cone turning', Neural Development, 4, (1) pp. 1-19. ISSN 1749-8104 (2009) [Refereed Article]

DOI: 10.1186/1749-8104-4-29 [eCite] [Details]

Citations: Scopus - 24Web of Science - 20

Co-authors: Gasperini RJ; Choi-Lundberg DL; Thompson MJW; Mitchell CB

Tweet

2005Journal ArticleFoa LC, Jensen K, Rajan I, Bronson K, Gasperini RJ, et al., 'Homer expression in the Xenopus tadpole nervous system', Journal of Comparative Neurology, 487, (1) pp. 42-53. ISSN 0021-9967 (2005) [Refereed Article]

DOI: 10.1002/cne.20496 [eCite] [Details]

Citations: Scopus - 11Web of Science - 9

Co-authors: Gasperini RJ

Tweet

2002Journal ArticleHaas K, Jensen K, Sin WC, Foa LC, Cline HT, 'Targeted electroporation in Xenopus tadpoles in vivo - from single cells to the entire brain', Differentiation, 70, (4-5) pp. 148-154. ISSN 0301-4681 (2002) [Refereed Article]

DOI: 10.1046/j.1432-0436.2002.700404.x [eCite] [Details]

Citations: Scopus - 101Web of Science - 86

Tweet

2001Journal ArticleFoa LC, Rajan I, Haas K, Wu G, Brakeman P, et al., 'The scaffold protein, Homer 1b/c, regulates axon pathfinding in the central nervous system in vivo', Nature Neuroscience, 4, (5) pp. 499-506. ISSN 1097-6256 (2001) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 50

Journal Article

(26 outputs)
YearCitationAltmetrics
2017Gasperini RJ, Pavez M, Thompson AC, Mitchell Camila, Hardy H, et al., 'How does calcium interact with the cytoskeleton to regulate growth cone motility during axon pathfinding?', Molecular and Cellular Neurosciences ISSN 1044-7431 (In Press) [Refereed Article]

DOI: 10.1016/j.mcn.2017.07.006 [eCite] [Details]

Co-authors: Gasperini RJ; Pavez M; Thompson AC; Young KM

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2016Wang S, Bolos M, Clark R, Cullen CL, Southam KA, et al., 'Amyloid β precursor protein regulates neuron survival and maturation in the adult mouse brain', Molecular and Cellular Neurosciences, 77 pp. 21-33. ISSN 1044-7431 (2016) [Refereed Article]

DOI: 10.1016/j.mcn.2016.09.002 [eCite] [Details]

Citations: Scopus - 4Web of Science - 3

Co-authors: Wang S; Bolos M; Clark R; Cullen CL; Southam KA; Dickson TC; Young KM

Tweet

2016Auderset L, Landowski LM, Foa L, Young KM, 'Low density lipoprotein receptor related proteins as regulators of neural stem and progenitor cell function', Stem Cells International Article 2108495. ISSN 1687-9678 (2016) [Refereed Article]

DOI: 10.1155/2016/2108495 [eCite] [Details]

Citations: Scopus - 5Web of Science - 6

Co-authors: Landowski LM; Young KM

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2015Landowski LM, Pavez M, Brown LS, Gasperini R, Taylor BV, et al., 'Low-density lipoprotein receptor-related proteins in a novel mechanism of axon guidance and peripheral nerve regeneration', Journal of Biological Chemistry, 291, (3) pp. 1092-1102.. ISSN 1083-351X (2015) [Refereed Article]

DOI: 10.1074/jbc.M115.668996 [eCite] [Details]

Citations: Scopus - 5Web of Science - 3

Co-authors: Landowski LM; Pavez M; Brown LS; Gasperini R; Taylor BV; West AK

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2014Bolos M, Hu Y, Young KM, Foa L, Small DH, 'Neurogenin 2 mediates amyloid-β precursor protein-stimulated neurogenesis', Journal of Biological Chemistry, 289, (45) pp. 31253-31261. ISSN 0021-9258 (2014) [Refereed Article]

DOI: 10.1074/jbc.M114.581918 [eCite] [Details]

Citations: Scopus - 4Web of Science - 5

Co-authors: Bolos M; Hu Y; Young KM; Small DH

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2014Dawkins E, Gasperini R, Hu Y, Cui H, Vincent AJ, et al., 'The N-terminal fragment of the β-amyloid precursor protein of Alzheimer's disease (N-APP) binds to phosphoinositide-rich domains on the surface of hippocampal neurons', Journal of Neuroscience Research, 92, (11) pp. 1478-1489. ISSN 1097-4547 (2014) [Refereed Article]

DOI: 10.1002/jnr.23422 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Dawkins E; Gasperini R; Hu Y; Cui H; Vincent AJ; Bolos M; Young KM; Small DH

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2014Small DH, Hu Y, Bolos M, Dawkins E, Foa L, et al., 'β-Amyloid precursor protein: function in stem cell development and Alzheimer's disease brain', Neurodegenerative Diseases, 13, (2-3) pp. 96-98. ISSN 1660-2854 (2014) [Refereed Article]

DOI: 10.1159/000353686 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Small DH; Hu Y; Bolos M; Dawkins E; Young KM

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2013Hu Y, Hung AC, Cui H, Dawkins E, Bolos M, et al., 'Role of cystatin C in amyloid precursor protein-induced proliferation of neural stem/progenitor cells', Journal of Biological Chemistry, 288, (26) pp. 18853-18862. ISSN 0021-9258 (2013) [Refereed Article]

DOI: 10.1074/jbc.M112.443671 [eCite] [Details]

Citations: Scopus - 11Web of Science - 11

Co-authors: Hu Y; Hung AC; Cui H; Dawkins E; Bolos M; Young KM; Small DH

Tweet

2012Mitchell CB, Gasperini RJ, Small DH, Foa LC, 'STIM1 is necessary for store-operated calcium entry in turning growth cones', Journal of Neurochemistry, 122, (6) pp. 1155-66. ISSN 0022-3042 (2012) [Refereed Article]

DOI: 10.1111/j.1471-4159.2012.07840.x [eCite] [Details]

Citations: Scopus - 21Web of Science - 22

Co-authors: Gasperini RJ; Small DH

Tweet

2011Gasperini RJ, Hou X, Parkington H, Coleman H, Klaver DW, et al., 'TRPM8 and Nav 1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons', Molecular Neurodegeneration, 6, (19) pp. 1-12. ISSN 1750-1326 (2011) [Refereed Article]

DOI: 10.1186/1750-1326-6-19 [eCite] [Details]

Citations: Scopus - 9Web of Science - 7

Co-authors: Gasperini RJ; Klaver DW; Vincent AJ; Small DH

Tweet

2010Kerr ML, Gasperini R, Gibbs ME, Hou X, Shepherd CE, et al., 'Inhibition of Aβ aggregation and neurotoxicity by the 39-kDa receptor-associated protein', Journal of Neurochemistry, 112, (5) pp. 1199-1209. ISSN 0022-3042 (2010) [Refereed Article]

DOI: 10.1111/j.1471-4159.2009.06540.x [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Gasperini R; Small DH

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2010Klaver D, Hung AC, Gasperini R, Foa L, Aguilar MI, et al., 'Effect of Heparin on APP Metabolism and Aβ Production in Cortical Neurons', Neurodegenerative Diseases, 7, (1-3) pp. 187-189. ISSN 1660-2854 (2010) [Refereed Article]

DOI: 10.1159/000295661 [eCite] [Details]

Citations: Scopus - 6Web of Science - 7

Co-authors: Klaver D; Hung AC; Gasperini R; Small DH

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2010Klaver DW, Wilce MCJ, Cui H, Hung AC, Gasperini R, et al., 'Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions', Biological Chemistry: Official Journal of The German Society for Biochemistry and Molecular Biology, 391, (8) pp. 849-859. ISSN 1431-6730 (2010) [Refereed Article]

DOI: 10.1515/BC.2010.089 [eCite] [Details]

Citations: Scopus - 29Web of Science - 26

Co-authors: Klaver DW; Cui H; Hung AC; Gasperini R; Small DH

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2010Klaver DW, Wilce MCJ, Gasperini R, Freeman C, Juliano JP, et al., 'Glycosaminoglycan-induced activation of the β-secretase (BACE1) of Alzheimer's disease', Journal of Neurochemistry, 112, (6) pp. 1552-1561. ISSN 0022-3042 (2010) [Refereed Article]

DOI: 10.1111/j.1471-4159.2010.06571.x [eCite] [Details]

Citations: Scopus - 15Web of Science - 15

Co-authors: Klaver DW; Gasperini R; Small DH

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2010Liu SJ, Gasperini R, Foa L, Small DH, 'Amyloid-beta Decreases Cell-Surface AMPA Receptors by Increasing Intracellular Calcium and Phosphorylation of GluR2', Journal of Alzheimer's Disease, 21, (2) pp. 655-666. ISSN 1387-2877 (2010) [Refereed Article]

DOI: 10.3233/JAD-2010-091654 [eCite] [Details]

Citations: Scopus - 34Web of Science - 30

Co-authors: Liu SJ; Gasperini R; Small DH

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2010Small DH, Klaver DW, Foa L, 'Presenilins and the gamma-secretase: still a complex problem', Molecular Brain, 3, (1) pp. 1-6. ISSN 1756-6606 (2010) [Refereed Article]

DOI: 10.1186/1756-6606-3-7 [eCite] [Details]

Citations: Scopus - 18Web of Science - 18

Co-authors: Small DH; Klaver DW

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2010Staal JA, Dickson TC, Gasperini R, Liu Y, Foa L, et al., 'Initial calcium release from intracellular stores followed by calcium dysregulation is linked to secondary axotomy following transient axonal stretch injury', Journal of Neurochemistry, 112, (5) pp. 1147-1155. ISSN 0022-3042 (2010) [Refereed Article]

DOI: 10.1111/j.1471-4159.2009.06531.x [eCite] [Details]

Citations: Scopus - 51Web of Science - 44

Co-authors: Staal JA; Dickson TC; Gasperini R; Liu Y; Vickers JC

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2010Vincent AJ, Gasperini R, Foa L, Small DH, 'Astrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity', Journal of Alzheimer's Disease, 22, (3) pp. 699-714. ISSN 1387-2877 (2010) [Refereed Article]

DOI: 10.3233/JAD-2010-101089 [eCite] [Details]

Citations: Scopus - 31Web of Science - 31

Co-authors: Vincent AJ; Gasperini R; Small DH

Tweet

2009Foa LC, Gasperini RJ, 'Developmental roles for Homer: more than just a pretty scaffold', Journal of Neurochemistry, 108, (1) pp. 1-10. ISSN 0022-3042 (2009) [Refereed Article]

DOI: 10.1111/j.1471-4159.2008.05726.x [eCite] [Details]

Citations: Scopus - 26Web of Science - 23

Co-authors: Gasperini RJ

Tweet

2009Gasperini RJ, Choi-Lundberg DL, Thompson MJW, Mitchell CB, Foa LC, 'Homer regulates calcium signalling in growth cone turning', Neural Development, 4, (1) pp. 1-19. ISSN 1749-8104 (2009) [Refereed Article]

DOI: 10.1186/1749-8104-4-29 [eCite] [Details]

Citations: Scopus - 24Web of Science - 20

Co-authors: Gasperini RJ; Choi-Lundberg DL; Thompson MJW; Mitchell CB

Tweet

2009Small DH, Gasperini R, Vincent AJ, Hung AC, Foa L, 'The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer's Disease', Journal of Alzheimer's Disease, 16, (2) pp. 225-233. ISSN 1387-2877 (2009) [Refereed Article]

DOI: 10.3233/JAD-2009-0951 [eCite] [Details]

Citations: Scopus - 51Web of Science - 45

Co-authors: Small DH; Gasperini R; Vincent AJ; Hung AC

Tweet

2005Foa LC, Jensen K, Rajan I, Bronson K, Gasperini RJ, et al., 'Homer expression in the Xenopus tadpole nervous system', Journal of Comparative Neurology, 487, (1) pp. 42-53. ISSN 0021-9967 (2005) [Refereed Article]

DOI: 10.1002/cne.20496 [eCite] [Details]

Citations: Scopus - 11Web of Science - 9

Co-authors: Gasperini RJ

Tweet

2005Gasperini RJ, Foa LC, 'Homer 1b/c expression correlates with zebrafish olfactory system development', Journal of Neurocytology, 33, (6) pp. 671-680. ISSN 0300-4864 (2005) [Refereed Article]

DOI: 10.1007/s11068-005-3335-x [eCite] [Details]

Citations: Scopus - 5Web of Science - 4

Co-authors: Gasperini RJ

Tweet

2002Haas K, Jensen K, Sin WC, Foa LC, Cline HT, 'Targeted electroporation in Xenopus tadpoles in vivo - from single cells to the entire brain', Differentiation, 70, (4-5) pp. 148-154. ISSN 0301-4681 (2002) [Refereed Article]

DOI: 10.1046/j.1432-0436.2002.700404.x [eCite] [Details]

Citations: Scopus - 101Web of Science - 86

Tweet

2001Foa LC, Rajan I, Haas K, Wu G, Brakeman P, et al., 'The scaffold protein, Homer 1b/c, regulates axon pathfinding in the central nervous system in vivo', Nature Neuroscience, 4, (5) pp. 499-506. ISSN 1097-6256 (2001) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 50

1998Foa LC, Cooke IRC, 'The ontogeny of GABA- and glutamate-like immunoreactivity in the embryonic Australian freshwater crayfish, Cherax destructor', Developmental Brain Research, 107, (1) pp. 33-42. ISSN 0165-3806 (1998) [Refereed Article]

DOI: 10.1016/S0165-3806(97)00216-2 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

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Chapter in Book

(1 outputs)
YearCitationAltmetrics
2012Gasperini RJ, Foa L, 'Methods in neuronal growth cone biology', TRP Channels in Drug Discovery. Methods in Pharmacology and Toxicology, Humana Press, T Biro & A Szallasi (ed), New York, pp. 239-252. ISBN 978-1-62703-094-6 (2012) [Research Book Chapter]

DOI: 10.1007/978-1-62703-095-3 [eCite] [Details]

Co-authors: Gasperini RJ

Tweet

Conference Publication

(27 outputs)
YearCitationAltmetrics
2015Landowski LM, Pavez M, Gasperini RJ, Taylor BVM, West AK, et al., 'Low-density lipoprotein receptor-related proteins guide navigating PNS axons', 2015 PNS Meeting, 28 June - 2 July, 2015, Quebec City, Canada (2015) [Conference Extract]

[eCite] [Details]

Co-authors: Landowski LM; Pavez M; Gasperini RJ; Taylor BVM; West AK

2014Bolos M, Hu Y, Foa L, Young K, Small D, 'The role of Neurogenin2 in APP-stimulated neural stem or progenitor cell differentiation', 34th Annual Meeting Australasian Neuroscience Society, January, Adelaide, Australia (2014) [Conference Extract]

[eCite] [Details]

Co-authors: Bolos M; Hu Y; Young K; Small D

2014Hu Y, Bolos M, Dawkins E, Foa L, Young K, et al., 'Cystatin C regulates neural stem or progenitor cell proliferation (Poster)', 34th Annual Meeting Australasian Neuroscience Society, January, Adelaide, Australia (2014) [Conference Extract]

[eCite] [Details]

Co-authors: Hu Y; Bolos M; Dawkins E; Young K; Small D

2014Landowski LM, Pavez M, Gasperini RJ, Taylor BVM, West AK, et al., 'LRP receptors in a novel mechanism of axon pathfinding and peripheral nerve regeneration', Neuroscience 2014, November 15-19, 2015, Washington DC (2014) [Conference Extract]

[eCite] [Details]

Co-authors: Landowski LM; Pavez M; Gasperini RJ; Taylor BVM; West AK

2014Landowski LM, Pavez M, Gasperini RJ, Taylor BVM, West AK, et al., 'LRP receptors in a novel mechanism of axon pathfinding and peripheral nerve regeneration', Neuroscience 2014, 15-19 November, 2014, Washington, DC (2014) [Conference Extract]

[eCite] [Details]

Co-authors: Landowski LM; Pavez M; Gasperini RJ; Taylor BVM; West AK

2014Landowski LM, Taylor BVM, West AK, Foa LC, 'Identification of novel neurotrophic-like factors: a candidate for promoting nerve regeneration in neuropathy', ANS Adelaide 2014, Jan 28-31, 2014, Adelaide, Australia (2014) [Conference Extract]

[eCite] [Details]

Co-authors: Landowski LM; Taylor BVM; West AK

2014Bolos M, Hu Y, Foa L, Young KM, Small DH, 'APP regulates neural stem or progenitor cell differentiation through neurogenin 2 expresssion', Federation of European Neuroscience Societies, 5-9 July, Milan, Italy (2014) [Conference Extract]

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Co-authors: Bolos M; Hu Y; Young KM; Small DH

2013Hu Y, Hung AC, Cui H, Dawkins E, Foa L, et al., 'APP stimulates neural stem/progenitor cell proliferation by increasing cystatin C secretion. (Poster)', 33rd Annual Meeting Australian Neuroscience Society, January, Melbourne, Australia (2013) [Conference Extract]

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Co-authors: Hu Y; Hung AC; Cui H; Dawkins E; Young KM; Small DH

2013Dawkins E, Vincent AJ, Gasperini R, Cui H, Young K, et al., 'A direct interaction of Aβ with anionic cellular lipids mediates binding to neurons (Poster)', 12th International Conference on Alzheimer's and Parkinson's Diseases, Florence, Italy (2013) [Conference Extract]

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Co-authors: Dawkins E; Vincent AJ; Gasperini R; Cui H; Young K; Small DH

2012Dawkins EA, Gasperini R, Vincent AJ, Foa LC, Small DH, 'Analysis of Aβ cell interactions and uptake in hippocampal culture', Proceedings of the 32nd Annual Meeting of the Australian Neuroscience Society, 29 January - 1 February 2012, Gold Coast, Australia, pp. 34. (2012) [Conference Extract]

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Co-authors: Dawkins EA; Gasperini R; Vincent AJ; Small DH

2012Landowski LM, Gasperini RJ, Taylor BVM, West AK, Foa LC, 'Metallothionein I/II induces growth cone chemotaxis via an LRP 1 and LRP 2 dependent mechanism', Neuroscience 2012, 13-17 October, 2012, New Orleans, Louisiana (2012) [Conference Extract]

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Co-authors: Landowski LM; Gasperini RJ; Taylor BVM; West AK

2012Landowski LM, Gasperini RJ, Taylor BVM, West AK, Foa LC, 'Metallothionein I/II induces growth cone chemotaxis via an LRP 1 and LRP 2 dependent mechanism', Neuroscience 2012, 13-17 October, 2012, New Orleans, Louisiana (2012) [Conference Extract]

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Co-authors: Landowski LM; Gasperini RJ; Taylor BVM; West AK

2011Hadrill CE, Gasperini RJ, Dickson TC, Foa LC, Small DH, 'Regulation of the cell adhesion molecule, L1CAM by the Aβ peptide of Alzheimer's Disease', Australian Neuroscience Society 31st Annual Meeting, 31 Jan - 3 Feb, Auckland, New Zealand (2011) [Conference Extract]

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Co-authors: Hadrill CE; Gasperini RJ; Dickson TC; Small DH

2011Hoang T, Gasperini RJ, Cui H, Shepherd CE, Strickland DK, et al., 'Interaction of the receptor-associated protein (RAP) with APP and Aβ', Australian Neuroscience Society 31st Annual Meeting, 31 Jan - 3 Feb, Auckland, New Zealand (2011) [Conference Extract]

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Co-authors: Hoang T; Gasperini RJ; Cui H; Small DH

2011Landowski LM, Gasperini RJ, Small DH, Taylor BVM, West AK, et al., 'Metallothionein I/II and metallothionein III induce growth cone chemotaxis via disparate mechanisms', Australian Neuroscience Society 31st Annual Meeting, 31 Jan - 3 Feb, Auckland, New Zealand (2011) [Conference Extract]

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Co-authors: Landowski LM; Gasperini RJ; Small DH; Taylor BVM; West AK

2011Mitchell C, Gasperini RJ, Small DH, Foa LC, 'STIM1 is necessary for regulation of growth cone motility', Australian Neuroscience Society 31st Annual Meeting, 31 Jan - 3 Feb, Auckland, New Zealand (2011) [Conference Extract]

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Co-authors: Gasperini RJ; Small DH

2011Small DH, Klaver D, Liu S, Cui H, Hoang T, et al., 'Disruption of protein trafficking in Alzheimer's Disease: APP, Aβ and AMPA receptors', Australian Neuroscience Society 31st Annual Meeting, 31 Jan - 3 Feb, Auckland, New Zealand (2011) [Conference Extract]

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Co-authors: Small DH; Klaver D; Liu S; Cui H; Hoang T; Gasperini RJ

2009Gasperini RJ, Thompson M, Foa LC, 'Homer1 expression in the growth cone: regulating calcium homeostasis', Proceedings of the Australian Neuroscience Society, 27-30 January 2009, Canberra, pp. 45. (2009) [Conference Extract]

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Co-authors: Gasperini RJ; Thompson M

2009Mitchell CB, Gasperini RJ, Foa LC, 'Homer and store operated calcium entry in growth cone motility', Spinal Cord Research Symposium, Queensland Brain Institute, pp. 8. (2009) [Conference Extract]

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Co-authors: Mitchell CB; Gasperini RJ

2009Vickers JC, Staal JA, Gasperini RJ, Foa LC, Liu Y, et al., 'Axonal stretch injury in vitro results in initial release of calcium from intracellular stores, prolonged calcium mismetabolism and secondary degeneration', Society for Neuroscience, 17-21 Oct, Chicago, pp. 214.2. (2009) [Conference Extract]

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Co-authors: Vickers JC; Staal JA; Gasperini RJ; Liu Y; Dickson TC

2008Gasperini RJ, Thompson MJW, Foa LC, 'Homer1 is necessary for maintaining calcium homeostasis in the growth cone', 2nd Brain Plasticity Symposium, 9-12 September 2008, Brisbane, pp. 16. (2008) [Conference Extract]

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Co-authors: Gasperini RJ; Thompson MJW

2007Gasperini RJ, Foa LC, 'Homer is a key regulator of calcium dynamics in motile growth cones', 7th IBRO World Congress of Neuroscience, 12-17 July 2007, Melbourne, pp. 355. (2007) [Conference Extract]

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Co-authors: Gasperini RJ

2006Gasperini RJ, Foa LC, 'Homer is a molecular correlate of growth cone turning', Proceedings of the Australian Neuroscience Society, 31 Jan - 3 Feb 2006, Sydney, pp. 37. ISSN 1034-3237 (2006) [Conference Extract]

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Co-authors: Gasperini RJ

2005Gasperini RJ, Foa LC, 'Homer expression and early sensory circuit development in the zebrafish', Proceedings of the Australian Neuroscience Society, 30 Jan - 2 Feb 2005, Perth, pp. 57. ISSN 1034-3237 (2005) [Conference Extract]

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Co-authors: Gasperini RJ

2004Haas MA, Vickers JC, Foa LC, Dickson TC, 'L1 and ERM proteins are involved in regenerative sprouting following neuronal trauma in vitro', 34th Annual Meeting for the Society for Neuroscience, San Diego, pp. 391.17. (2004) [Conference Extract]

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Co-authors: Haas MA; Vickers JC; Dickson TC

2002Chuckowree JA, Foa LC, Vickers JC, 'Microtubule stabilization inhibits neurite development and post-injury axonal sprouting in vitro', 32nd Annual Meeting for the Society for Neuroscience, November 2002, Florida, USA, pp. 133.8. (2002) [Conference Extract]

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Co-authors: Chuckowree JA; Vickers JC

2002Yee KC, Walls JT, Nicol SC, Foa LC, 'A case based approach to pharmacology teaching: the local experience', Proceedings of the 7th National Forum on Prevocational Medical Education, 7-8 Nov, Hobart, TAS (2002) [Conference Extract]

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Co-authors: Yee KC; Walls JT; Nicol SC

Grants & Funding

Funding Summary

Number of grants

23

Total funding

$2,925,002

Projects

Short chain quinones against diabetic retinopathy (2016 - 2019)$75,174
Description
We will test novel short chain quinones against idebenone and related compounds in a rat model of diabetic retinopathy.
Funding
Santhera Pharmaceuticals Holding AG ($75,174)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Guven N; Premilovac D; Foa LC
Period
2016 - 2019
Generating and characterizing a reliable rodent model type 2 diabetes (2016)$14,673
Funding
University of Tasmania ($14,673)
Scheme
Grant-Research Enhancement (REGS)
Administered By
University of Tasmania
Research Team
Premilovac D; Foa LC; Taylor BVM; Guven N
Year
2016
Hazelwood coal mine fire emissions: Are there risks for infant brain development? (2016)$14,959
Funding
University of Tasmania ($14,959)
Scheme
Grant-Research Enhancement (REGS)
Administered By
University of Tasmania
Research Team
Wheeler A; Johnston F; Zosky GR; Foa LC
Year
2016
Promoting regrowth of nerve fibres into the epidermis during diabetic neuropathy by LRP agonists (2015 - 2017)$413,731
Funding
National Health & Medical Research Council ($413,731)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Foa LC; Taylor BVM; West AK; Keske MAV
Period
2015 - 2017
Grant Reference
1088952
Development of a therapeutic agent for a chemotherapy-induced neuropathy (2015)$21,739
Description
Chemotherapy-induced neuropathy (CIN) is a dose-limiting side effect of chemotherapy treatment, causing irreversible disability in 40% of cancer survivors. CIN results from the loss or damage of neurons during chemotherapy. We have compelling evidence that the protein metallothionein promotes regeneration of peripheral nerves, and examine its therapeutic use in CIN.This project will create new knowledge in the area of chemotherapy induced neuropathy, and establish the suitability of trophic agents as disease-modifying agents for chemotherapy-induced neuropathy.
Funding
Royal Hobart Hospital Research Foundation ($21,739)
Scheme
Grant-Clinical Research
Administered By
University of Tasmania
Research Team
Taylor BVM; Landowski LM; West AK; Vickers JC; Foa LC; Guven N
Year
2015
Repulsion and Attraction: How do LRPs turn growth cones? (2014 - 2016)$358,447
Funding
National Health & Medical Research Council ($358,447)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Foa LC; West AK; Gasperini RJ
Period
2014 - 2016
Grant Reference
1068317
Neuron to glia signalling: learning how synaptic signalling can promote CNS remyelination (2014 - 2016)$589,583
Description
Oligodendrocyte progenitor cell (OPC) and oligodendrocyte damage contribute significantly to the mental and physical impairmentsseen in periventricular leukomalacia (pre and postnatal white matter injury leading to cerebral palsy), spinal cord injury, CNS inflammation, multiple sclerosis and stroke (see background). We have previously demonstrated that new oligodendrocytes are continuously born and added to the central nervous system (CNS), formed from resident OPCs (Rivers*, Young* et al., 2008; Psachoulia et al., 2009; Clarke*, Young* et al., 2012), and that these OPCs have a significant capacity for generating larger numbers of oligodendrocytes in response to a demyelinating injury (Tripathi et al., 2010; Zawadzka et al., 2010).However this endogenous repair system will need to be therapeutically enhanced in order achieve efficacious repair, as many of the newborn OPCs remain in an immature state and fail to differentiate into mature, myelinating oligodendrocytes (Tripathi et al., 2010). There is a body of evidence demonstrating that electrical activity from neurons to OPCs (synaptic and extrasynaptic) in the form of glutamate, GABA and ATP signalling, instructs OPC proliferation, migration, differentiation and myelination (see background). Furthermore, neuronal activity induces an intracellular calcium signal in OPC that instructs the local translation of myelin proteins (Wake et al., 2011). By combining Dr Youngs expertise in OPC biology, Dr Foas expertise in calcium signalling and Dr Gasperinis expertise in synapse biochemistry, we aim to identify key regulators in the pathway coupling neuronal electrical transmission with OPC intracellular calcium signalling, and subsequently OPC differentiation, in a bid to identify therapeutic targets that will increase axon-OPC connectivity,oligodendrocyte differentiation, survival and myelination for the treatment of de/dysmyelinating disorders.
Funding
National Health & Medical Research Council ($589,583)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Young Kaylene; Foa LC; Gasperini RJ
Period
2014 - 2016
Grant Reference
1066025
Transient receptor potential channels, calcium and Alzheimer's disease (2013 - 2015)$390,758
Funding
National Health & Medical Research Council ($390,758)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Small DH; Foa LC; Vickers JC; Parkington H; Coleman Harry
Period
2013 - 2015
Grant Reference
1042566
Do metallothioneins promote and direct regenerative growth of epidermal nerve fibres in diabetic peripheral neuropathy? (2013)$33,000
Funding
Brain Foundation ($33,000)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
West AK; Taylor BVM; Foa LC
Year
2013
Establishing a state-of-the-art 'Live Cell Recording and Imaging Facility' at Menzies Research Institute Tasmania (2013)$22,000
Funding
Rebecca L Cooper Medical Research Foundation ($22,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Young Kaylene; Small DH; Foa LC; Dickson TC
Year
2013
The role of store-operated calcium entry in neuronal development (2012 - 2014)$341,175
Funding
National Health & Medical Research Council ($341,175)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Foa LC; Small DH; Gell DA
Period
2012 - 2014
Grant Reference
1024145
Calcium signals in neurons: a dynamic role for the endoplasmic reticulum (2012)$4,800
Funding
The Select Foundation ($4,800)
Scheme
Grant-Small Grants Scheme
Administered By
University of Tasmania
Research Team
Gasperini RJ; Mitchell C; Foa LC
Year
2012
Understanding the cause of Alzheimer's disease (2012)$177,325
Funding
National Health & Medical Research Council ($177,325)
Scheme
Grant-Dementia Seed Funding
Administered By
University of Tasmania
Research Team
Small DH; Foa LC; Vickers JC
Year
2012
Grant Reference
1020843
Multidimensional analysis of biomarkers for the early detection of Alzheimer's disease using in vivo MRS (2011)$45,600
Funding
The Mason Foundation ($45,600)
Scheme
Grant-Judith Jane Mason & Harold Stannett Williams
Administered By
University of Tasmania
Research Team
Small DH; Edwards LM; Foa LC
Year
2011
Establishing a high-resolution, live cell fluoresence imaging facility at the Menzies Research Institute, University of Tasmania (2010)$100,000
Funding
Ian Potter Foundation ($100,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Foa LC
Year
2010
Post Synaptic Density Scaffold proteins in the growth cone: Homer and Shank, crucial for calcium signaling (2008 - 2010)$228,250
Funding
National Health & Medical Research Council ($228,250)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Foa LC
Period
2008 - 2010
Grant Reference
512801
Mechanisms of Metallothioneins and Homer in Chemoattraction (2007)$10,000
Funding
University of Tasmania ($10,000)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Foa LC
Year
2007
Wiring Functional Brain Circuits: Is There a Role for Homer and Metallothioneins Proteins? (2006)$7,560
Funding
University of Tasmania ($7,560)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Foa LC
Year
2006
Leica DMIRB Inverted Microscope Configured for Fluorescence and Bright Field with Phase Contrast (2005)$10,000
Funding
National Health & Medical Research Council ($10,000)
Scheme
Grant-Equipment
Administered By
University of Tasmania
Research Team
Chuah MI; West AK; Holloway AF; Rattigan S; Richards SM; Chung RS; Foa LC
Year
2005
Grant Reference
264668
Homer and Growth Cones: Unravelling the Jigsaw of Nerve Cell Connections in the Brain (2005 - 2006)$10,000
Funding
Masonic Centenary Medical Research Foundation ($10,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Foa LC
Period
2005 - 2006
Homer Genes and their Role in the Wiring of the Brain's Electrical Circuit (2004)$9,091
Funding
Royal Hobart Hospital Research Foundation ($9,091)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Foa LC
Year
2004
Does Homer function in axon pathfinding within the embryonic Zebrafish olfactory system? (2003)$29,000
Funding
Clive & Vera Ramaciotti Foundation ($29,000)
Scheme
Grant-Establishment
Administered By
University of Tasmania
Research Team
Foa LC
Year
2003
The Behaviour of Learning and Memory Genes in the Ageing Brain (2002)$18,137
Funding
Masonic Centenary Medical Research Foundation ($18,137)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Foa LC
Year
2002

Research Supervision

Current

10

Completed

7

Current

DegreeTitleCommenced
PhDDeciphering the Role of STIM1 in Nervous System Development2013
PhDElucidating the Mechanisms of Cell Activity Required for Neurodevelopment2014
PhDDevelopment of optogenetic approaches to modulate synaptic plasticity in the postsynaptic cells2014
PhDUnderstanding the Function of ST1M1 in Coordinating Calcium Signalling2015
PhDMitochondrial Therapy against Diabetic Retinopathy2016
PhDThe Role of LRP1 in Promoting Oligodendrocyte Repair in Multiple Sclerosis2016
PhDDevelopment and Optimisation of Optogenetic Tools to Control the G Protein-coupled Receptor Pathway and Their Use in Identifying Chromatin State Changes During Memory2017
PhDThe Health Impacts of Hazelwood Coal Fire Particles2017
PhDDeciphering Brain Connectivity: From circuits to function2017
PhDPericyte Regulation of Blood Flow in the Brain and its Dysfunction Following Stroke2017

Completed

DegreeTitleCompleted
PhDTowards Understanding the Mechanism of Clioquinol Neurotoxicity
Candidate: Jamuna Chhetri
2017
PhDRole of Amyloid Precursor Protein in Neural Stem/Progenitor Cell Proliferation and Differentiation
Candidate: Yanling Hu
2016
PhDMolecular Mechanisms Used by Staphylococcus Aureus to Access Iron from Human Haemoglobin
Candidate: Claire Frances Dickson
2014
PhDLRP Receptors in a Novel Mechanism of Axon Pathfinding and Peripheral Nerve Regeneration
Candidate: Lila Maree Landowski
2014
PhDRole of Phosphoinositides in the Biology of the Amyloid Precursor Protein
Candidate: Edgar Adam Henry Dawkins
2014
PhDSTIM1 Mediates Multiple Signalling Pathways in Neuronal Growth Cones
Candidate: Camilla Bessie Mitchell
2013
PhDHomer, TRP Channels and Calcium: The Signalling Triad of Growth Cone Motility
Candidate: Robert John Gasperini
2008