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Renee Dwyer

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Renee Dwyer

Lecturer in Biomedicine

Room Level 2, Medical Science Precinct: MS2, Hobart CBD Campuses

+61 3 6226 4685 (phone)

+61 3 6226 4788 (fax)

Renee.Dwyer@utas.edu.au

Biography

Dr Dwyer is a Teaching and Research based Academic in the School of Medicine.  She teaches undergraduate physiology and biochemistry into a number of courses within the Faculty of Health, and coordinates Year 2 of the MBBS degree.  Her research focuses on muscle metabolism, vascular function and exercise in the context of type 2 diabetes development and treatment.

Career summary

Qualifications

  • PhD, Exercise and Insulin: Muscle Haemodynamics and Metabolism, University of Tasmania, 2007
  • GradDipSci (Hons), Cytokines and Insulin action in perfused muscle, University of Tasmania, 2003
  • BHM (Hons), The Effects of Caffeine on Anaerobic Performance after Prolonged Exercise in Trained Cyclists, University of Tasmania, 2002

Memberships

Professional practice

  •  Member of the Australian Physiological Society

Teaching

Biochemistry, Physiology, Respiratory Physiology, Metabolism, Diabetes

Teaching expertise

Dr Dwyer teaches both biochemistry and physiology into the Bachelor of Medical Research and MBBS courses.

Teaching responsibility

Unit Coordinator: CAM201 Fundamentals of Clinical Science 1

www.utas.edu.au/courses/M3Nwww.utas.edu.au/units/CAM201

View more on Dr Renee Ross in WARP

Expertise

Dr Dwyer's research has a broad focus on the role of exercise in the prevention and treatment of insulin resistance and cardiovascular disease.  Research themes include:

  • Investigating the mechanisms which regulate glucose metabolism in skeletal muscle, including microvascular blood flow
  • Examining the effect of physical activity interventions in both clinical and workplace settings
  • Assessing the impact of shift work on chronic markers of health

Research Themes

Dr Dwyer's research aligns to the University's research theme of Better Health.  The number of people who are overweight or obese is rising rapidly worldwide, with poor lifestyle and decreased physical activity levels being major contributors.  Obesity is associated with an increased risk of developing cardiovascular disease and type 2 diabetes, diseases which effect ~30% of the Australian population.  A common feature of these conditions is insulin resistance which primarily effects the liver, skeletal muscle and blood vessels.  Renee's research focuses on the development of insulin resistance in these tissues and how exercise and nutritional interventions can be used to help prevent and treat insulin resistance and type 2 diabetes.

Current projects

Fields of Research

  • Endocrinology (110306)
  • Cardiology (incl. Cardiovascular Diseases) (110201)
  • Systems Physiology (111603)
  • Physiology (060699)
  • Medicine, Nursing and Health Curriculum and Pedagogy (130209)
  • Medical Bacteriology (110801)
  • Medical and Health Sciences (119999)
  • Public Nutrition Intervention (111104)
  • Health and Community Services (111708)
  • Animal Physiology - Biophysics (060601)
  • Epigenetics (incl. Genome Methylation and Epigenomics) (060404)
  • Medical Biotechnology (100499)
  • Cell Metabolism (060104)
  • Motor Control (110603)
  • Medical Biochemistry: Amino Acids and Metabolites (110101)

Research Objectives

  • Diabetes (920104)
  • Cardiovascular System and Diseases (920103)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Infectious Diseases (920109)
  • Assessment and Evaluation of Curriculum (930301)
  • Endocrine Organs and Diseases (excl. Diabetes) (920106)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Expanding Knowledge in the Biological Sciences (970106)
  • Inherited Diseases (incl. Gene Therapy) (920110)
  • Human Pharmaceutical Treatments (e.g. Antibiotics) (860803)
  • Human Diagnostics (860802)
  • Nutrition (920411)
  • Clinical Health (Organs, Diseases and Abnormal Conditions) (920199)

Publications

Total publications

27

Highlighted publications

(2 outputs)
YearTypeCitationAltmetrics
2007Journal ArticleRoss RM, Kolka CM, Rattigan S, Clark MG, 'Acute blockade by endothelin-1 of haemodynamic insulin action in rats', Diabetologia, 50, (2) pp. 443-451. ISSN 0012-186X (2007) [Refereed Article]

DOI: 10.1007/s00125-006-0525-8 [eCite] [Details]

Citations: Scopus - 26Web of Science - 23

Co-authors: Kolka CM; Rattigan S; Clark MG

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2007Journal ArticleRoss RM, Wadley GD, Clark MG, Rattigan S, McConell GK, 'Local nitric oxide synthase inhibition reduces skeletal muscle glucose uptake but not capillary blood flow during in situ muscle contraction in rats', Diabetes, 56, (12) pp. 2885-2892. ISSN 0012-1797 (2007) [Refereed Article]

DOI: 10.2337/db07-0745 [eCite] [Details]

Citations: Scopus - 50Web of Science - 51

Co-authors: Clark MG; Rattigan S

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Journal Article

(17 outputs)
YearCitationAltmetrics
2018Hu D, Russell RD, Remash D, Greenaway T, Rattigan S, et al., 'Are the metabolic benefits of resistance training in type 2 diabetes linked to improvements in adipose tissue microvascular blood flow?', American Journal of Physiology: Endocrinology and Metabolism, 315, (6) pp. E1242-E1250. ISSN 0193-1849 (2018) [Refereed Article]

DOI: 10.1152/ajpendo.00234.2018 [eCite] [Details]

Co-authors: Russell RD; Remash D; Greenaway T; Rattigan S; Squibb KA; Jones G; Premilovac D; Richards SM; Keske MA

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2017Giblin R, Bennet E, Zosky GR, Dwyer RM, 'The Impact of Sex and 25(OH)D Deficiency on Metabolic Function in Mice', Nutrients, 9, (9) pp. 1-14. ISSN 2072-6643 (2017) [Refereed Article]

DOI: 10.3390/nu9090985 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Bennet E; Zosky GR

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2017Keske MA, Dwyer RM, Russell RD, Blackwood SJ, Brown AA, et al., 'Regulation of microvascular flow and metabolism: An overview', Clinical and Experimental Pharmacology and Physiology, 44, (1) pp. 143-149. ISSN 0305-1870 (2017) [Refereed Article]

DOI: 10.1111/1440-1681.12688 [eCite] [Details]

Citations: Scopus - 5Web of Science - 6

Co-authors: Keske MA; Russell RD; Blackwood SJ; Brown AA; Premilovac D; Richards SM; Rattigan S

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2017Russell RD, Hu D, Greenaway T, Blackwood SJ, Dwyer RM, et al., 'Skeletal muscle microvascular-linked improvements in glycemic control from resistance training in individuals with Type 2 Diabetes', Diabetes Care, 40, (9) pp. 1256-1263. ISSN 0149-5992 (2017) [Refereed Article]

DOI: 10.2337/dc16-2750 [eCite] [Details]

Citations: Scopus - 7Web of Science - 5

Co-authors: Russell RD; Greenaway T; Blackwood SJ; Sharman JE; Jones G; Squibb KA; Brown AA; Otahal P; Al-Aubaidy H; Premilovac D; Hitchins S; Richards SM; Rattigan S; Keske MA

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2017Blackwood SJ, Dwyer RM, Bradley EA, Keske MA, Richards SM, et al., 'Determination of skeletal muscle microvascular flowmotion with contrast-enhanced ultrasound', Ultrasound in Medicine and Biology, 43, (9) pp. 2013-2023. ISSN 0301-5629 (2017) [Refereed Article]

DOI: 10.1016/j.ultrasmedbio.2017.05.012 [eCite] [Details]

Co-authors: Blackwood SJ; Bradley EA; Keske MA; Richards SM; Rattigan S

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2016Keske MA, Premilovac D, Bradley EA, Dwyer RM, Richards SM, et al., 'Muscle microvascular blood flow responses in insulin resistance and ageing', The Journal of Physiology, 594, (8) pp. 2223-2231. ISSN 1469-7793 (2016) [Refereed Article]

DOI: 10.1113/jphysiol.2014.283549 [eCite] [Details]

Citations: Scopus - 18Web of Science - 21

Co-authors: Keske MA; Premilovac D; Bradley EA; Richards SM; Rattigan S

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2015Hong YH, Betik AC, Premilovac D, Dwyer RM, Keske MA, et al., 'No effect of NOS inhibition on skeletal muscle glucose uptake during in situ hindlimb contraction in healthy and diabetic Sprague-Dawley rats', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 308, (10) pp. R862-R871. ISSN 0363-6119 (2015) [Refereed Article]

DOI: 10.1152/ajpregu.00412.2014 [eCite] [Details]

Citations: Scopus - 6Web of Science - 7

Co-authors: Premilovac D; Keske MA; Rattigan S

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2013Edwards LM, Kemp GJ, Dwyer RM, Walls JT, Fuller H, et al., 'Integrating muscle cell biochemistry and whole-body physiology in humans: 31P-MRS data from the InSight trial', Scientific Reports, 3 Article 1182. ISSN 2045-2322 (2013) [Refereed Article]

DOI: 10.1038/srep01182 [eCite] [Details]

Citations: Scopus - 8Web of Science - 5

Co-authors: Edwards LM; Walls JT

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2012Edwards LM, Tyler DJ, Kemp GJ, Dwyer RM, Johnson A, et al., 'The reproducibility of 31-phosphorous MRS measures of muscle energetics at 3 tesla in trained men', PLoS One, 7, (6) Article e37237. ISSN 1932-6203 (2012) [Refereed Article]

DOI: 10.1371/journal.pone.0037237 [eCite] [Details]

Citations: Scopus - 15Web of Science - 14

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2010Merry TL, Dwyer RM, Bradley EA, Rattigan S, McConell GK, 'Local hindlimb antioxidant infusion does not affect muscle glucose uptake during in situ contractions in rat', Journal of Applied Physiology, 108, (5) pp. 1275-1283. ISSN 8750-7587 (2010) [Refereed Article]

DOI: 10.1152/japplphysiol.01335.2009 [eCite] [Details]

Citations: Scopus - 16Web of Science - 15

Co-authors: Bradley EA; Rattigan S

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2009Newman JMB, Dwyer RM, St Pierre P, Richards SM, Clark MG, et al., 'Decreased microvascular vasomotion and myogenic response in rat skeletal muscle in association with acute insulin resistance', Journal of Physiology, 587, (11) pp. 2579-2588. ISSN 0022-3751 (2009) [Refereed Article]

DOI: 10.1113/jphysiol.2009.169011 [eCite] [Details]

Citations: Scopus - 45Web of Science - 42

Co-authors: Newman JMB; Richards SM; Clark MG; Rattigan S

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2009Yuen DYC, Dwyer RM, Matthews VB, Zhang L, Drew BG, et al., 'Interleukin-6 attenuates insulin-mediated increases in endothelial cell signaling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor-a expression', Diabetes, 58, (May) pp. 1086-1095. ISSN 0012-1797 (2009) [Refereed Article]

DOI: 10.2337/db08-0775 [eCite] [Details]

Citations: Scopus - 36Web of Science - 33

Co-authors: Zhang L; Clark MG; Rattigan S

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2008Ross RM, Downey KA, Newman JMB, Richards SM, Clark MG, et al., 'Contrast-enhanced ultrasound measurement of microvascular perfusion relevant to nutrient and hormone delivery in skeletal muscle: A model study in vitro', Microvascular Research, 75, (3) pp. 323-329. ISSN 0026-2862 (2008) [Refereed Article]

DOI: 10.1016/j.mvr.2007.11.002 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

Co-authors: Downey KA; Newman JMB; Richards SM; Clark MG; Rattigan S

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2007Newman JMB, Ross RM, Richards SM, Clark MG, Rattigan S, 'Insulin and contraction increase nutritive blood flow in rat muscle in vivo: determined by microdialysis of L-[14C]glucose', Journal of Physiology, 585, (1) pp. 217-229. ISSN 0022-3751 (2007) [Refereed Article]

DOI: 10.1113/jphysiol.2007.138818 [eCite] [Details]

Citations: Scopus - 14Web of Science - 13

Co-authors: Newman JMB; Richards SM; Clark MG; Rattigan S

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2007Rattigan S, Bussey CT, Ross RM, Richards SM, 'Obesity, Insulin Resistance, and Capillary Recruitment', Microcirculation, 14, (4-5) pp. 299-309. ISSN 1073-9688 (2007) [Refereed Article]

DOI: 10.1080/10739680701282796 [eCite] [Details]

Citations: Scopus - 24Web of Science - 21

Co-authors: Rattigan S; Bussey CT; Richards SM

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2007Ross RM, Kolka CM, Rattigan S, Clark MG, 'Acute blockade by endothelin-1 of haemodynamic insulin action in rats', Diabetologia, 50, (2) pp. 443-451. ISSN 0012-186X (2007) [Refereed Article]

DOI: 10.1007/s00125-006-0525-8 [eCite] [Details]

Citations: Scopus - 26Web of Science - 23

Co-authors: Kolka CM; Rattigan S; Clark MG

Tweet

2007Ross RM, Wadley GD, Clark MG, Rattigan S, McConell GK, 'Local nitric oxide synthase inhibition reduces skeletal muscle glucose uptake but not capillary blood flow during in situ muscle contraction in rats', Diabetes, 56, (12) pp. 2885-2892. ISSN 0012-1797 (2007) [Refereed Article]

DOI: 10.2337/db07-0745 [eCite] [Details]

Citations: Scopus - 50Web of Science - 51

Co-authors: Clark MG; Rattigan S

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Chapter in Book

(1 outputs)
YearCitationAltmetrics
2013Premilovac D, Ng HLH, Richards SM, Bradley EA, Dwyer RM, et al., 'Role for the Microvasculature in Glucose Uptake in Skeletal Muscle', Glucose Uptake: Regulation, Signaling Pathways and Health Implications (Endocrinology Research and Clinical Developments), Nova Science Publishers, Johnson CC and Williams DB (ed), New York, pp. 109-139. ISBN 978-1-62618-670-5 (2013) [Research Book Chapter]

[eCite] [Details]

Co-authors: Premilovac D; Ng HLH; Richards SM; Bradley EA; Rattigan S; Keske MA

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Conference Publication

(9 outputs)
YearCitationAltmetrics
2018Hays RB, Al-Aubaidy HAM, Cuellar WA, Dwyer RM, Williams A-MM, et al., 'Effects on student results and course evaluations of reduction in teaching hours in an undergraduate medical course', 15th Asia Pacific Medical Education Conference (AP, 10-14 January 2018, Singapore (2018) [Conference Extract]

[eCite] [Details]

Co-authors: Hays RB; Al-Aubaidy HAM; Cuellar WA; Williams A-MM; Choi-Lundberg DL

2017Williams LJ, Latham R, Dwyer RM, O'Toole RF, Tristram SG, et al., 'The Impacts of Iron Laden Particulate Matter on NTHi Growth', Australian Society for Microbiology Annual Scientific Meeting 2017, 2-5 July 2017, Hobart, Tasmania (2017) [Conference Extract]

[eCite] [Details]

Co-authors: Latham R; O'Toole RF; Tristram SG; Zosky GR

2011Newman JMB, Dwyer RM, Keske MAV, Richards SM, Rattigan S, 'Flow motion in skeletal muscle is associated with increased nutritive flow and insulin action', Proceedings of the 71st Scientific Sessions of the American Diabetes Association, 24-28 June, San Diego, California, pp. 1740-P. (2011) [Conference Extract]

[eCite] [Details]

Co-authors: Newman JMB; Keske MAV; Richards SM; Rattigan S

2011Rattigan S, Newman JMB, Dwyer RM, Richards S, Keske MAV, 'Flow motion in skeletal muscle microvasculature is associated with increased nutritive flow', Australia and New Zealand Microcirculation Society Conference, 30 Nov - 3 Dec, Western Australia (2011) [Conference Extract]

[eCite] [Details]

Co-authors: Rattigan S; Newman JMB; Keske MAV

2006Clark MG, Dwyer RM, Newman JMB, Richards SM, Rattigan S, 'A comparison of ultrasound and laser Doppler for Measuring Capillary Recruitment Using Models in vitro', Proceedings, 27-30 September, 2006, Indianapolis, pp. 10. (2006) [Conference Extract]

[eCite] [Details]

Co-authors: Clark MG; Newman JMB; Richards SM; Rattigan S

2006Dwyer RM, Kolka CM, Rattigan S, Clark MG, 'Endothelin-1 inhibits insulin action in vivo', Diabetologia, vol 49, Supplement 1, 14-17 September, 2006, Copenhagen-Malmo, pp. 373. ISSN 0012-186X (2006) [Conference Extract]

[eCite] [Details]

Co-authors: Rattigan S; Clark MG

2006Dwyer RM, Newman JMB, Richards SM, Rattigan S, Clark MG, 'Laser Doppler flowmetry, but not contrast enhanced ultrasound, influenced by flow when measuring changes in muscle capillary recruitment - a study in vitro', Proceedings of Meeting, 13th September, 2006, Copenhagen, pp. 16. (2006) [Conference Extract]

[eCite] [Details]

Co-authors: Newman JMB; Richards SM; Rattigan S; Clark MG

2006Newman JMB, Clark MG, Dwyer RM, Richards SM, Rattigan S, 'Use of microdialysis to assess capillary recruitment in muscle - a study in vitro', Proceedings of Meeting, 13th September, 2006, Copenhagen, pp. 17. (2006) [Conference Extract]

[eCite] [Details]

Co-authors: Newman JMB; Clark MG; Richards SM; Rattigan S

2004Steinberg GR, Dwyer RM, Carey AL, Rogers S, Richards SM, et al., 'Interleukin-6 increases glucose uptake but does not increase AMPK activity in L6 myotubes and perfused rat hindlimb', Proceedings of AMPK Meeting, 23-26 March, 2004, Lorne, pp. 126. (2004) [Conference Extract]

[eCite] [Details]

Co-authors: Richards SM; Rattigan S; Clark MG

Grants & Funding

Funding Summary

Number of grants

2

Total funding

$627,268

Projects

Cardiometabolic benefits of exercise training in type 2 diabetes independent of weight loss (2014)$50,735
Description
This project will recruit an overweight type 2 diabetes cohort, medically assessed for an exercise program. It aims to recruit some with family history of type 2 diabetes and some without. The cohort with exercise test before and after 6 weeks of the exercise program, with type 2 medications discontinued before test. The aim is to show that heart health will not be as good with family history of type 2 and that exercise will improve heart health but will be of more benefit to those with a family history than those without.
Funding
University of Tasmania ($50,735)
Scheme
vTAHSP Demonstration Projects
Administered By
University of Tasmania
Research Team
Keske MAV; Greenaway T; Marwick TH; Ross RM; Rattigan S; Sharman JE; Premilovac D
Year
2014
Role of microvascular flowmotion in skeletal muscle glucose metabolism (2013 - 2015)$576,533
Description
Obesity and type 2 diabetes are nationally and globally reaching epidemic rates. This project investigates the regulation of blood flow within muscle and its impact on metabolism. Outcomes from the study may lead to diagnostic tools and treatments for cardiovascular disease associated with obesity, hypertension and type 2 diabetes.
Funding
National Health & Medical Research Council ($576,533)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Rattigan S; Keske MAV; Richards SM; Ross RM
Period
2013 - 2015
Grant Reference
1043474_HF

Research Supervision

Dr Dwyer has supervised candidates at the Masters and PhD level.

Current

3

Completed

1

Current

DegreeTitleCommenced
MastersTransition into Ambulance Shiftwork: A study of sleep patterns and sleep quality for new shiftworkers2015
PhDExposure to Iron Laden Particulate Matter Impacts on Respiratory Health2016
PhDResponsiveness of In Vitro and In Vivo Skeletal Muscle Pericytes to Circulating and Muscle-Derived Paracrine Vasoactive Molecules2018

Completed

DegreeTitleCompleted
PhDCharacterisation of Flowmotion in Healthy Controls and Type 2 Diabetes
Candidate: Sarah Joan Blackwood
2017