Profiles

David Small

UTAS Home Prof David Small

David Small

Professorial Research Fellow
Menzies Institute for Medical Research

Hobart CBD Campuses

(03) 6226 7348 (phone)

D.H.Small@utas.edu.au

Prof Small is an NHMRC Senior Research Fellow at the Menzies Institute for Medical Research, University of Tasmania. David's research interests include neurodegenerative diseases (development of diagnostic tests for Alzheimer's disease, mechanisms of amyloid folding and aggregation, amyloid toxicity, therapeutics), cholinergic neurobiology (acetylcholinesterase), protein glycosylation, extracellular matrix and heparan sulfate proteoglycans, protease and neuronal cell biology. His work encompasses papers in the fields of nanotechnology (scanning tunnelling microscopy), biochemistry, molecular and cell biology, neuropharmacology, clinical diagnostics, computational neuroscience and behavioural testing.  He is well known internationally in the field of Alzheimer' disease, especially for his work on the molecular mechanisms that underlie changes in acetylcholinesterase expression in Alzheimer's disease brain and on the structure and metabolism of the b-amyloid precursor protein.

Biography

Professor Small was born in 1956 in Hobart, Tasmania, but he grew up and received most of his early education in Canada.  He returned to Australia in late 1977 and completed his PhD in the biochemistry department of The University of Melbourne in 1981. After postdoctoral research at MIT (Boston), he returned to Australia (Flinders Uni, Adelaide) in 1985. He moved back to the University of Melbourne in 1986 as an NHMRC Australian Postdoctoral Fellow. In 1991, he was awarded an NHMRC RD Wright Fellowship and in 1993 he was awarded an NHMRC Research Fellowship.  He became an NHMRC Senior Research Fellow in 1996 and has been continuously within the NHMRC fellowships scheme ever since.  He moved to Monash University in March 2003, and in 2008, he took up his present position at the Menzies Institute for Medical Research at the University of Tasmania. He has received continuous NHMRC project/program grant funding since 1990.

Career summary

Qualifications

  • PhD, University of Melbourne. 1981. Thesis: Methylation of Myelin Basic Protein
  • BSc. (High Hons), University of Saskatchewan, Canada. 1977

Languages (other than English)

  • French (fluent/bilingual proficiency)
  • Spanish (excellent working proficiency)
  • German (basic proficiency)

Memberships

Professional practice

  • Australian Neuroscience Society (ANS), Editor (an Executive position) (2008-2012)
  • Asian Pacific Society for Neurochemistry Council and membership of the International Proteolysis Society Scientific Advisory Committee, Member (2009)
  • International Society for Neurochemistry Publications Committee, Member (2006-2008)
  • International Society for Neurochemistry Internet Committee, Member (2001-2004)
  • International Scientific Advisory Committee for Cholinesterase Conferences, Member (1998-2004)
  • International Conference on Peptidases and Neuropeptide Processing, Chair (1991)

Administrative expertise

  • Deputy Director,  Monash University Centre for Brain and Behaviour (2003-2006) 
  • Deputy Director, Menzies Research Institute Tasmania (2009-2011)
  • NHMRC Grant Review Panels
  • NHMRC Fellowships Panel

Teaching

Neuroscience, Alzheimer's Disease, Biochemistry, Molecular Biology, Cell Biology

Research Invitations

Prof Small has received more than 50 invitations to chair and speak at major international conferences.

View more on Professor David Small in WARP

Research Themes

Professor Small's research interests centre on the molecular neurobiology of Alzheimer's disease and align with the University's theme of Better Health. His team is looking at basic mechanisms of disease causation with a view to the development of novel therapeutic strategies.

Collaboration

Within the University of Tasmania Prof Small works in collaboration with Dr Lisa Foa and Dr Kaylene Young (Menzies Institute for Medical Research). He also collaborates with Profs Mibel Aguilar and Helena Parkington (Monash University).

Current projects

Fields of Research

  • Neurosciences (110999)
  • Cellular Nervous System (110902)
  • Cell Neurochemistry (060105)
  • Neurology and Neuromuscular Diseases (110904)
  • Central Nervous System (110903)
  • Biochemistry and Cell Biology (060199)
  • Pharmaceutical Sciences (111504)
  • Autonomic Nervous System (110901)
  • Peripheral Nervous System (110905)
  • Clinical Chemistry (diagnostics) (110302)
  • Clinical Pharmacology and Therapeutics (111502)
  • Biologically Active Molecules (030401)
  • Cell Physiology (111601)
  • Basic Pharmacology (111501)
  • Animal Cell and Molecular Biology (060802)
  • Plant Cell and Molecular Biology (060702)
  • Animal Physiology - Systems (060603)
  • Cell Development, Proliferation and Death (060103)

Research Objectives

  • Neurodegenerative Disorders Related to Ageing (920112)
  • Nervous System and Disorders (920111)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Expanding Knowledge in the Biological Sciences (970106)
  • Health Related to Ageing (920502)
  • Health (929999)
  • Human Pharmaceutical Treatments (e.g. Antibiotics) (860803)
  • Urogenital System and Disorders (920119)
  • Cancer and Related Disorders (920102)
  • Human Biological Preventatives (e.g. Vaccines) (860801)
  • Coastal and Estuarine Flora, Fauna and Biodiversity (960802)
  • Preventive Medicine (920412)
  • Mental Health (920410)
  • Aquaculture Fin Fish (excl. Tuna) (830102)
  • Expanding Knowledge in the Environmental Sciences (970105)
  • Health and Support Services (920299)

Publications

Prof Small's published work has an h-index of 40 and has been cited more than 4970 times.  He has published 170 papers in refereed international journals, including major journals such as Proc. Natl. Acad. Sci. USA (1), Trends Biochem. Sci. (1), Nature Rev. Neurosci. (1), Trends Neurosci. (2), Neuron (1), Lancet (1), J. Neurosci. (3), Trends Mol. Med. (1), J. Biol. Chem. (6), Biochemistry (6), Brain (1) and J. Neurochem.(30).

Prof Small has been twice Deputy Chief Editor (DCE) of J Neurochem and has been a senior editor (equivalent to DCE) of Journal of Neuroscience Research and Journal of Alzheimer's Disease. He has served on the editorial board of 7 journals.

Total publications

127

Highlighted publications

(12 outputs)
YearTypeCitationAltmetrics
2008Journal ArticlePetratos S, Li QX, George AJ, Hou X, Kerr ML, et al., 'The beta-amyloid protein of Alzheimers disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism', Brain, 131, (1) pp. 90-108. ISSN 0006-8950 (2008) [Refereed Article]

DOI: 10.1093/brain/awm260 [eCite] [Details]

Citations: Scopus - 121Web of Science - 113

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2008ReviewSmall DH, 'Network dysfunction in Alzheimer's disease: does synaptic scaling drive disease progression?', Trends in Molecular Medicine, 14, (3) pp. 103-108. (2008) [Substantial Review]

DOI: 10.1016/j.molmed.2007.12.006 [eCite] [Details]

Citations: Scopus - 63Web of Science - 58

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2007Journal ArticleSmall DH, Maksel D, Kerr ML, Ng J, Hou X, et al., 'The β-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the α7 nicotinic acetylcholine receptor', Journal of Neurochemistry, 101, (6) pp. 1527-1538. ISSN 0022-3042 (2007) [Refereed Article]

DOI: 10.1111/j.1471-4159.2006.04444.x [eCite] [Details]

Citations: Scopus - 83Web of Science - 81

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2006Journal ArticleLosic D, Martin LL, Mechler A, Aguilar MI, Small DH, 'High resolution scanning tunnelling microscopy of the β-amyloid protein (Aβ1-40) of Alzheimer's disease suggests a novel mechanism of oligomer assembly', Journal of Structural Biology, 155, (1) pp. 104-110. ISSN 1047-8477 (2006) [Refereed Article]

DOI: 10.1016/j.jsb.2006.02.013 [eCite] [Details]

Citations: Scopus - 48Web of Science - 45

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2004Journal ArticleSmall DH, 'Do acetylcholinesterase inhibitors boost synaptic scaling in Alzheimer's disease?', Trends in Neurosciences, 27, (5) pp. 245-249. ISSN 0166-2236 (2004) [Refereed Article]

DOI: 10.1016/j.tins.2004.03.006 [eCite] [Details]

Citations: Scopus - 28Web of Science - 26

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2001Journal ArticleSmall DH, Mok SS, Bornstein JC, 'Alzheimer's disease and Aβ toxicity: from top to bottom', Nature Reviews Neuroscience, 2 pp. 595-598. ISSN 1471-003X (2001) [Refereed Article]

[eCite] [Details]

1997Journal ArticleSaez-Valero J, Sberna G, McLean CA, Masters CL, Small DH, 'Glycosylation of acetylcholinesterase as diagnostic marker for Alzheimer's disease', The Lancet, 350 pp. 929. ISSN 0140-6736 (1997) [Letter or Note in Journal]

[eCite] [Details]

1996Journal ArticleWilliamson TG, Mok SS, Henry A, Cappai R, Lander AD, et al., 'Secreted Glypican Binds to the Amyloid Precursor Protein of Alzheimer's Disease (APP) and Inhibits APP-induced Neurite Outgrowth', Journal of Biological Chemistry, 271, (49) pp. 31215-31221. ISSN 0021-9258 (1996) [Refereed Article]

DOI: 10.1074/jbc.271.49.31215 [eCite] [Details]

Citations: Scopus - 83Web of Science - 85

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1995Journal ArticleSmall DH, Reed G, Whitefield B, Nurcombe V, 'Cholinergic Regulation of Neurite Outgrowth from Isolated Chick Sympathetic Neurons in Culture', Journal of Neuroscience, 15, (1) pp. 144-151. ISSN 0270-6474 (1995) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 126

1994Journal ArticleSmall DH, Nurcombe V, Reed G, Clarris H, Moir R, et al., 'A Heparin-binding Domain in the Amyloid Protein Precursor of Alzheimer's Disease Is Involved in the Regulation of Neurite Outgrowth', Journal of Neuroscience, 14, (4) pp. 2117-2127. ISSN 0270-6474 (1994) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 306

1992Journal ArticleMilward EA, Papadopoulos R, Fuller SJ, Moir RD, Small D, et al., 'The Amyloid Protein Precursor of Alzheimer's Disease Is a Mediator of the Effects of Nerve Growth Factor on Neurite Outgrowth', Neuron, 9 pp. 129-137. ISSN 0896-6273 (1992) [Refereed Article]

[eCite] [Details]

1992Journal ArticleSmall DH, Nurcombe V, Moir R, Michaelson S, Monard D, et al., 'Association and Release of the Amyloid Protein Precursor of Alzheimer's Disease from Chick Brain Extracellular Matrix', Journal of Neuroscience, 12, (11) pp. 4143-4150. ISSN 0270-6474 (1992) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 80

Journal Article

(104 outputs)
YearCitationAltmetrics
2018Southam KA, Stennard F, Pavez C, Small DH, 'Knockout of amyloid β protein precursor (APP) expression alters synaptogenesis, neurite branching and axonal morphology of hippocampal neurons', Neurochemical Research pp. 1-10. ISSN 0364-3190 (2018) [Refereed Article]

DOI: 10.1007/s11064-018-2512-0 [eCite] [Details]

Co-authors: Southam KA; Stennard F; Pavez C

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2017Cui H, King AE, Jacobson GA, Small DH, 'Peripheral treatment with enoxaparin exacerbates amyloid plaque pathology in Tg2576 mice', Journal of Neuroscience Research, 95, (4) pp. 992-999. ISSN 0360-4012 (2017) [Refereed Article]

DOI: 10.1002/jnr.23880 [eCite] [Details]

Citations: Scopus - 2

Co-authors: Cui H; King AE; Jacobson GA

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2016Southam KA, Vincent AJ, Small DH, 'Do microglia default on network maintenance in Alzheimer's disease?', Journal of Alzheimer's Disease, 51, (3) pp. 657-669. ISSN 1387-2877 (2016) [Refereed Article]

DOI: 10.3233/JAD-151075 [eCite] [Details]

Citations: Scopus - 12Web of Science - 11

Co-authors: Southam KA; Vincent AJ

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2016Smith AI, Rajapakse NW, Kleifeld O, Lomonte B, Sikanyika NL, et al., 'N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin', Scientific Reports, 6 Article 22413. ISSN 2045-2322 (2016) [Refereed Article]

DOI: 10.1038/srep22413 [eCite] [Details]

Citations: Scopus - 8Web of Science - 6

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2014Dawkins E, Small DH, 'Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease', Journal of Neurochemistry, 129, (5) pp. 756-769. ISSN 0022-3042 (2014) [Refereed Article]

DOI: 10.1111/jnc.12675 [eCite] [Details]

Citations: Scopus - 102Web of Science - 95

Co-authors: Dawkins E

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2014Small DH, Hu Y, Bolos M, Dawkins E, Foa L, et al., 'β-Amyloid precursor protein: function in stem cell development and Alzheimer's disease brain', Neurodegenerative Diseases, 13, (2-3) pp. 96-98. ISSN 1660-2854 (2014) [Refereed Article]

DOI: 10.1159/000353686 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Hu Y; Bolos M; Dawkins E; Foa L; Young KM

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2014Bolos M, Hu Y, Young KM, Foa L, Small DH, 'Neurogenin 2 mediates amyloid-β precursor protein-stimulated neurogenesis', Journal of Biological Chemistry, 289, (45) pp. 31253-31261. ISSN 0021-9258 (2014) [Refereed Article]

DOI: 10.1074/jbc.M114.581918 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

Co-authors: Bolos M; Hu Y; Young KM; Foa L

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2014Dawkins E, Gasperini R, Hu Y, Cui H, Vincent AJ, et al., 'The N-terminal fragment of the β-amyloid precursor protein of Alzheimer's disease (N-APP) binds to phosphoinositide-rich domains on the surface of hippocampal neurons', Journal of Neuroscience Research, 92, (11) pp. 1478-1489. ISSN 1097-4547 (2014) [Refereed Article]

DOI: 10.1002/jnr.23422 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Dawkins E; Gasperini R; Hu Y; Cui H; Vincent AJ; Bolos M; Young KM; Foa L

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2013Hu Y, Hung AC, Cui H, Dawkins E, Bolos M, et al., 'Role of cystatin C in amyloid precursor protein-induced proliferation of neural stem/progenitor cells', Journal of Biological Chemistry, 288, (26) pp. 18853-18862. ISSN 0021-9258 (2013) [Refereed Article]

DOI: 10.1074/jbc.M112.443671 [eCite] [Details]

Citations: Scopus - 18Web of Science - 17

Co-authors: Hu Y; Hung AC; Cui H; Dawkins E; Bolos M; Foa L; Young KM

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2013Cui H, Freeman C, Jacobson GA, Small DH, 'Proteoglycans in the central nervous system: Role in development, neural repair, and Alzheimer's disease', IUBMB Life, 65, (2) pp. 108-120. ISSN 1521-6543 (2013) [Refereed Article]

DOI: 10.1002/iub.1118 [eCite] [Details]

Citations: Scopus - 41Web of Science - 39

Co-authors: Cui H; Jacobson GA

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2012Zhai J, Lee TH, Small DH, Aguilar M-I, 'Characterization of early stage intermediates in the nucleation phase of Aβ aggregation', Biochemistry, 51, (6) pp. 1070-1078. ISSN 0006-2960 (2012) [Refereed Article]

DOI: 10.1021/bi201871r [eCite] [Details]

Citations: Scopus - 19Web of Science - 18

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2012Cui H, Hung AC, Freeman C, Narkowicz C, Jacobson GA, et al., 'Size and sulfation are critical for the effect of heparin on APP processing and A beta production', Journal of Neurochemistry, 123, (3) pp. 447-457. ISSN 0022-3042 (2012) [Refereed Article]

DOI: 10.1111/j.1471-4159.2012.07929.x [eCite] [Details]

Citations: Scopus - 9Web of Science - 8

Co-authors: Cui H; Hung AC; Narkowicz C; Jacobson GA

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2012Small DH, 'Dysregulation of Ca2+ homeostasis in Alzheimer's disease: role in acetylcholinesterase production and AMPA receptor internalization', Neurodegenerative Diseases, 10, (1-4) pp. 76-79. ISSN 1660-2854 (2012) [Refereed Article]

DOI: 10.1159/000333126 [eCite] [Details]

Citations: Scopus - 5Web of Science - 6

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2012Small DH, Aguilar M-I, 'Targeting pre-mRNA splicing: a BACE-ic strategy for AD drug development?', Journal of Neurochemistry, 121, (5) pp. 695-696. ISSN 0022-3042 (2012) [Letter or Note in Journal]

DOI: 10.1111/j.1471-4159.2012.07679.x [eCite] [Details]

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2012Gasperini RJ, Small DH, 'Neurodegeneration in Familal Amyloidotic Polyneuropathy', Clinical and Experimental Pharmacology and Physiology, 39, (8) pp. 680-683. ISSN 0305-1870 (2012) [Refereed Article]

DOI: 10.1111/j.1440-1681.2011.05607.x [eCite] [Details]

Citations: Scopus - 7Web of Science - 5

Co-authors: Gasperini RJ

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2012Mitchell CB, Gasperini RJ, Small DH, Foa LC, 'STIM1 is necessary for store-operated calcium entry in turning growth cones', Journal of Neurochemistry, 122, (6) pp. 1155-66. ISSN 0022-3042 (2012) [Refereed Article]

DOI: 10.1111/j.1471-4159.2012.07840.x [eCite] [Details]

Citations: Scopus - 27Web of Science - 26

Co-authors: Gasperini RJ; Foa LC

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2012Silveyra M-X, Garcia-Ayllon M-S, de Barreda EG, Small DH, Martinez S, et al., 'Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice', Neurobiology of Aging: Experimental and Clinical Research, 33, (3) pp. 624.e23- 624.e34. ISSN 0197-4580 (2012) [Refereed Article]

DOI: 10.1016/j.neurobiolaging.2011.03.006 [eCite] [Details]

Citations: Scopus - 15Web of Science - 2

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2011Garcia-Ayllon MS, Small DH, Avila J, Saez-Valero J, 'Revisiting the role of acetylcholinesterase in Alzheimer's disease: cross-talk with P-tau and β-amyloid', Frontiers in Molecular Neuroscience, 4 Article 22. ISSN 1662-5099 (2011) [Refereed Article]

DOI: 10.3389/fnmol.2011.00022 [eCite] [Details]

Citations: Scopus - 70

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2011Gasperini RJ, Hou X, Parkington H, Coleman H, Klaver DW, et al., 'TRPM8 and Nav 1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons', Molecular Neurodegeneration, 6, (19) pp. 1-12. ISSN 1750-1326 (2011) [Refereed Article]

DOI: 10.1186/1750-1326-6-19 [eCite] [Details]

Citations: Scopus - 13Web of Science - 8

Co-authors: Gasperini RJ; Klaver DW; Vincent AJ; Foa LC

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2011Hou X, Small DH, Aguilar MI, 'Surface Plasmon Resonance Spectroscopy: A New Lead in Studying the Membrane Binding of Amyloidogenic Transthyretin', Methods in Molecular Biology, 752 pp. 215-228. ISSN 1064-3745 (2011) [Refereed Article]

DOI: 10.1007/978-1-60327-223-0_14 [eCite] [Details]

Citations: Scopus - 1

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2011Cui H, Hung AC, Klaver DW, Suzuki T, Freeman C, et al., 'Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice', PLoS One, 6, (7) Article e23007. ISSN 1932-6203 (2011) [Refereed Article]

DOI: 10.1371/journal.pone.0023007 [eCite] [Details]

Citations: Scopus - 15Web of Science - 7

Co-authors: Cui H; Hung AC; Klaver DW; Narkowicz C; Jacobson GA

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2010Klaver D, Hung AC, Gasperini R, Foa L, Aguilar MI, et al., 'Effect of Heparin on APP Metabolism and Aβ Production in Cortical Neurons', Neurodegenerative Diseases, 7, (1-3) pp. 187-189. ISSN 1660-2854 (2010) [Refereed Article]

DOI: 10.1159/000295661 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

Co-authors: Klaver D; Hung AC; Gasperini R; Foa L

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2010Klaver DW, Wilce MCJ, Cui H, Hung AC, Gasperini R, et al., 'Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions', Biological Chemistry: Official Journal of The German Society for Biochemistry and Molecular Biology, 391, (8) pp. 849-859. ISSN 1431-6730 (2010) [Refereed Article]

DOI: 10.1515/BC.2010.089 [eCite] [Details]

Citations: Scopus - 31Web of Science - 28

Co-authors: Klaver DW; Cui H; Hung AC; Gasperini R; Foa L

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2010Klaver DW, Wilce MCJ, Gasperini R, Freeman C, Juliano JP, et al., 'Glycosaminoglycan-induced activation of the β-secretase (BACE1) of Alzheimer's disease', Journal of Neurochemistry, 112, (6) pp. 1552-1561. ISSN 0022-3042 (2010) [Refereed Article]

DOI: 10.1111/j.1471-4159.2010.06571.x [eCite] [Details]

Citations: Scopus - 16Web of Science - 16

Co-authors: Klaver DW; Gasperini R; Foa L

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2010Liu SJ, Gasperini R, Foa L, Small DH, 'Amyloid-beta Decreases Cell-Surface AMPA Receptors by Increasing Intracellular Calcium and Phosphorylation of GluR2', Journal of Alzheimer's Disease, 21, (2) pp. 655-666. ISSN 1387-2877 (2010) [Refereed Article]

DOI: 10.3233/JAD-2010-091654 [eCite] [Details]

Citations: Scopus - 45Web of Science - 40

Co-authors: Liu SJ; Gasperini R; Foa L

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2010Small DH, Klaver DW, Foa L, 'Presenilins and the gamma-secretase: still a complex problem', Molecular Brain, 3, (1) pp. 1-6. ISSN 1756-6606 (2010) [Refereed Article]

DOI: 10.1186/1756-6606-3-7 [eCite] [Details]

Citations: Scopus - 19Web of Science - 20

Co-authors: Klaver DW; Foa L

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2010Kerr ML, Gasperini R, Gibbs ME, Hou X, Shepherd CE, et al., 'Inhibition of Aβ aggregation and neurotoxicity by the 39-kDa receptor-associated protein', Journal of Neurochemistry, 112, (5) pp. 1199-1209. ISSN 0022-3042 (2010) [Refereed Article]

DOI: 10.1111/j.1471-4159.2009.06540.x [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Gasperini R; Foa L

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2010Vincent AJ, Gasperini R, Foa L, Small DH, 'Astrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity', Journal of Alzheimer's Disease, 22, (3) pp. 699-714. ISSN 1387-2877 (2010) [Refereed Article]

DOI: 10.3233/JAD-2010-101089 [eCite] [Details]

Citations: Scopus - 45Web of Science - 41

Co-authors: Vincent AJ; Gasperini R; Foa L

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2009Beckman M, Freeman C, Parish CR, Small DH, 'Activation of cathepsin D by glycosaminoglycans', The F E B S Journal, 276, (24) pp. 7343-7352. ISSN 1742-464X (2009) [Refereed Article]

DOI: 10.1111/j.1742-4658.2009.07444.x [eCite] [Details]

Citations: Scopus - 14Web of Science - 15

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2009Small DH, Gasperini R, Vincent AJ, Hung AC, Foa L, 'The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer's Disease', Journal of Alzheimer's Disease, 16, (2) pp. 225-233. ISSN 1387-2877 (2009) [Refereed Article]

DOI: 10.3233/JAD-2009-0951 [eCite] [Details]

Citations: Scopus - 54Web of Science - 48

Co-authors: Gasperini R; Vincent AJ; Hung AC; Foa L

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2009Small DH, 'Dysregulation of Calcium Homeostasis in Alzheimer's Disease', Neurochemical Research, 34, (10) pp. 1824-1829. ISSN 0364-3190 (2009) [Refereed Article]

DOI: 10.1007/s11064-009-9960-5 [eCite] [Details]

Citations: Scopus - 65Web of Science - 63

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2008Gibbs ME, Maksel D, Gibbs Z, Hou X, Summers RJ, et al., 'Memory loss caused by s-amyloid protein is rescued by as3-adrenoceptor agonist', Neurobiology of Aging, 31, (4) EJ ISSN 0197-4580 (2008) [Refereed Article]

DOI: 10.1016/j.neurobiolaging.2008.05.018 [eCite] [Details]

Citations: Scopus - 32Web of Science - 31

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2008Petratos S, Li QX, George AJ, Hou X, Kerr ML, et al., 'The beta-amyloid protein of Alzheimers disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism', Brain, 131, (1) pp. 90-108. ISSN 0006-8950 (2008) [Refereed Article]

DOI: 10.1093/brain/awm260 [eCite] [Details]

Citations: Scopus - 121Web of Science - 113

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2008Azari MF, Ozturk E, Profyris C, Wang S, Small DH, et al., 'LIF treatment reduces Nogo-A deposits in spinal cord injury modulating Rho GTPase activity and CRMP-2 phosphorylation', Journal of Neurodegeneration and Regeneration, 1, (1) pp. 23-29. ISSN 1932-1481 (2008) [Refereed Article]

[eCite] [Details]

2008Hou X, Mechler A, Martin LL, Aguilar MI, Small DH, 'Cholesterol and anionic phospholipids increase the binding of amyloidogenic transthyretin to lipid membranes', Biochimica et Biophysica Acta, 1778, (1) pp. 198-205. ISSN 0005-2736 (2008) [Refereed Article]

DOI: 10.1016/j.bbamem.2007.09.018 [eCite] [Details]

Citations: Scopus - 20Web of Science - 19

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2007Hou X, Aguilar MI, Small DH, 'Transthyretin and familial amyloidotic polyneuropathy: Recent progress in understanding the molecular mechanism of neurodegeneration', The F E B S Journal, 274, (7) pp. 1637-1650. ISSN 1742-464X (2007) [Refereed Article]

DOI: 10.1111/j.1742-4658.2007.05712.x [eCite] [Details]

Citations: Scopus - 125Web of Science - 111

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2007Hou X, Parkington HC, Coleman HA, Mechler A, Martin LL, et al., 'Transthyretin oligomers induce calcium influx via voltage-gated calcium channels', Journal of Neurochemistry, 100, (2) pp. 446-457. ISSN 0022-3042 (2007) [Refereed Article]

DOI: 10.1111/j.1471-4159.2006.04210.x [eCite] [Details]

Citations: Scopus - 49Web of Science - 42

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2007Small DH, 'Neural Network Dysfunction in Alzheimer's Disease: A Drug Development Perspective', Drug News and Perspectives: The International Drug Newsmagazine, 20, (9) pp. 557-563. ISSN 0214-0934 (2007) [Refereed Article]

DOI: 10.1358/dnp.2007.20.9.1162245 [eCite] [Details]

Citations: Scopus - 7Web of Science - 7

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2007Small DH, Maksel D, Kerr ML, Ng J, Hou X, et al., 'The β-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the α7 nicotinic acetylcholine receptor', Journal of Neurochemistry, 101, (6) pp. 1527-1538. ISSN 0022-3042 (2007) [Refereed Article]

DOI: 10.1111/j.1471-4159.2006.04444.x [eCite] [Details]

Citations: Scopus - 83Web of Science - 81

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2006Beckman M, Holsinger RMD, Small DH, 'Heparin Activates β-Secretase (BACE1) of Alzheimer's Disease and Increases Autocatalysis of the Enzyme', Biochemistry, 45, (21) pp. 6703-6714. ISSN 0006-2960 (2006) [Refereed Article]

DOI: 10.1021/bi052498t [eCite] [Details]

Citations: Scopus - 39Web of Science - 39

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2006Azari MF, Profyris C, Small DH, Karnezis T, Bernard CC, 'Leukemia Inhibitory Factor Arrests Oligodendrocyte Death and Demyelination in Spinal Cord Injury', Journal of Neuropathology and Experimental Neurology, 65, (9) pp. 914-929. ISSN 0022-3069 (2006) [Refereed Article]

DOI: 10.1097/01.jnen.0000235855.77716.25 [eCite] [Details]

Citations: Scopus - 52Web of Science - 49

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2006Losic D, Martin LL, Mechler A, Aguilar MI, Small DH, 'High resolution scanning tunnelling microscopy of the β-amyloid protein (Aβ1-40) of Alzheimer's disease suggests a novel mechanism of oligomer assembly', Journal of Structural Biology, 155, (1) pp. 104-110. ISSN 1047-8477 (2006) [Refereed Article]

DOI: 10.1016/j.jsb.2006.02.013 [eCite] [Details]

Citations: Scopus - 48Web of Science - 45

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2006Mok SS, Losic D, Barrow CJ, Turner BJ, Masters CL, et al., 'The β-amyloid peptide of Alzheimer's disease decreases adhesion of vascular smooth muscle cells to the basement membrane', Journal of Neurochemistry, 96, (1) pp. 53-64. ISSN 0022-3042 (2006) [Refereed Article]

DOI: 10.1111/j.1471-4159.2005.03539.x [eCite] [Details]

Citations: Scopus - 24Web of Science - 23

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2006Small DH, Cappai R, 'Alois Alzheimer and Alzheimer's disease: a centennial perspective', Journal of Neurochemistry, 99, (3) pp. 708-710. ISSN 0022-3042 (2006) [Refereed Article]

DOI: 10.1111/j.1471-4159.2006.04212.x [eCite] [Details]

Citations: Scopus - 44Web of Science - 43

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2006Losic D, Martin LL, Aguilar MI, Small DH, 'β-amyloid fibril formation is promoted by step edges of highly oriented pyrolytic graphite', Biopolymers: Original Research on Biological Molecules and Assemblies, 84, (5) pp. 519-526. ISSN 0006-3525 (2006) [Refereed Article]

DOI: 10.1002/bip.20549 [eCite] [Details]

Citations: Scopus - 35Web of Science - 38

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2005Aguilar MI, Small DH, 'Surface Plasmon Resonance for the Analysis of β-Amyloid Interactions and Fibril Formation in Alzheimer's Disease Research', Neurotoxicity Research: An International Journal on Processes and Mechanisms in Neurodegeneration, Apoptosis, Neuroprotection and Regeneration, 7, (1-2) pp. 17-27. ISSN 1029-8428 (2005) [Refereed Article]

DOI: 10.1007/BF03033773 [eCite] [Details]

Citations: Scopus - 40Web of Science - 38

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2005Hou X, Richardson SJ, Aguilar MI, Small DH, 'Binding of Amyloidogenic Transthyretin to the Plasma Membrane Alters Membrane Fluidity and Induces Neurotoxicity', Biochemistry, 44, (30) pp. 11618-11627. ISSN 0006-2960 (2005) [Refereed Article]

DOI: 10.1021/bi050700m [eCite] [Details]

Citations: Scopus - 53Web of Science - 46

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2005Kerr ML, Small DH, 'Cytoplasmic Domain of the â-Amyloid Protein Precursor of Alzheimer's Disease: Function, Regulation of Proteolysis, and Implications for Drug Development', Journal of Neuroscience Research, 80, (2) pp. 151-159. ISSN 0360-4012 (2005) [Refereed Article]

DOI: 10.1002/jnr.20408 [eCite] [Details]

Citations: Scopus - 31Web of Science - 28

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2005Small DH, 'Acetylcholinesterase inhibitors for the treatment of dementia in Alzheimer's disease: do we need new inhibitors?', Expert Opinion on Emerging Drugs, 10, (4) pp. 817-825. ISSN 1744-7623 (2005) [Refereed Article]

DOI: 10.1517/14728214.10.4.817 [eCite] [Details]

Citations: Scopus - 31

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2005Small DH, 'Biochemical, Cellular and Behavioural Aspects of Neurodegeneration: the View from Down Under', Neurotoxicity Research: An International Journal on Processes and Mechanisms in Neurodegeneration, Apoptosis, Neuroprotection and Regeneration, 7, (1-2) pp. 1-3. ISSN 1029-8428 (2005) [Contribution to Refereed Journal]

DOI: 10.1007/BF03033771 [eCite] [Details]

Citations: Scopus - 1Web of Science - 2

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2004Fodero LR, Mok SS, Losic D, Martin LL, Aguilar MI, et al., 'α7-nicotinic acetylcholine receptors mediate an Aβ1-42-induced increase in the level of acetylcholinesterase in primary cortical neurons', Journal of Neurochemistry, 88, (5) pp. 1186-1193. ISSN 0022-3042 (2004) [Refereed Article]

DOI: 10.1046/j.1471-4159.2003.02296.x [eCite] [Details]

Citations: Scopus - 64Web of Science - 60

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2004Small DH, 'Mechanisms of synaptic homeostasis in Alzheimer's disease', Current Alzheimer Research, 1, (1) pp. 27-32. ISSN 1567-2050 (2004) [Refereed Article]

DOI: 10.2174/1567205043480573 [eCite] [Details]

Citations: Scopus - 26Web of Science - 22

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2004Small DH, 'Do acetylcholinesterase inhibitors boost synaptic scaling in Alzheimer's disease?', Trends in Neurosciences, 27, (5) pp. 245-249. ISSN 0166-2236 (2004) [Refereed Article]

DOI: 10.1016/j.tins.2004.03.006 [eCite] [Details]

Citations: Scopus - 28Web of Science - 26

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2004Small DH, Losic D, Martin LL, Turner BJ, Freidhuber A, et al., 'Alzheimer's disease therapeutics: new approaches to an ageing problem', I U B M B Life: (International Union of Biochemistry and Molecular Biology), 56, (4) pp. 203-208. ISSN 1521-6543 (2004) [Refereed Article]

DOI: 10.1080/15216540410001709211 [eCite] [Details]

Citations: Scopus - 8Web of Science - 5

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2003Klug GM, Losic D, Subasinghe SS, Aguilar MI, Martin LL, et al., 'β Amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH', The FEBS Journal, 270, (21) pp. 4282-4293. ISSN 1742-464X (2003) [Refereed Article]

DOI: 10.1046/j.1432-1033.2003.03815.x [eCite] [Details]

Citations: Scopus - 85Web of Science - 81

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2003Nunan J, Williamson NA, Hill AF, Sernee MF, Masters CL, et al., 'Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease β-amyloid protein precursor: effect of C-terminal truncation on the production of β-amyloid protein', Journal of Neuroscience Research, 74, (3) pp. 378-385. ISSN 0360-4012 (2003) [Refereed Article]

DOI: 10.1002/jnr.10646 [eCite] [Details]

Citations: Scopus - 46Web of Science - 49

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2003Saez-Valero J, Fodero LR, White AR, Barrow CJ, Small DH, 'Acetycholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with β-amyloid peptides', Brain Research: International Multidisciplinary Journal Devoted to Fundamental Research in The Brain Sciences, 965, (1-2) pp. 283-286. ISSN 0006-8993 (2003) [Refereed Article]

DOI: 10.1016/S0006-8993(02)04159-8 [eCite] [Details]

Citations: Scopus - 20Web of Science - 18

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2003Small DH, Smith AI, 'Proteases and proteolytic processing in the nervous system: key targets for drug development', Journal of Neuroscience Research, 74, (3) pp. 339-341. ISSN 0360-4012 (2003) [Contribution to Refereed Journal]

DOI: 10.1002/jnr.10782 [eCite] [Details]

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2003Subasinghe S, Unabia S, Barrow CJ, Mok SS, Aguilar MI, et al., 'Cholesterol is necessary both for the toxic effect of Aβ peptides on vascular smooth muscle cells and for Aβ binding to vascular smooth muscle cell membranes', Journal of Neurochemistry, 84, (3) pp. 471-479. ISSN 0022-3042 (2003) [Refereed Article]

DOI: 10.1046/j.1471-4159.2003.01552.x [eCite] [Details]

Citations: Scopus - 86Web of Science - 76

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2003Saez-Valero J, Fodero LR, Sjogren M, Andreasen N, Amici S, et al., 'Glycosylation of acetylcholinesterase and butyrylcholinesterase changes as a function of the duration of Alzheimer's disease', Journal of Neuroscience Research, 72, (4) pp. 520-526. ISSN 0360-4012 (2003) [Refereed Article]

DOI: 10.1002/jnr.10599 [eCite] [Details]

Citations: Scopus - 48Web of Science - 45

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2002Mok SS, Turner BJ, Beyreuther K, Masters CL, Barrow CJ, et al., 'Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine', European Journal of Biochemistry: The Febs Journal, 269, (12) pp. 3014-3022. ISSN 0014-2956 (2002) [Refereed Article]

DOI: 10.1046/j.1432-1033.2002.02976.x [eCite] [Details]

Citations: Scopus - 31Web of Science - 26

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2002Fodero LR, Saez-Valero J, McLean CA, Martins RN, Beyreuther K, et al., 'Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition', Journal of Neurochemistry , 81, (3) pp. 441-448. ISSN 0022-3042 (2002) [Refereed Article]

DOI: 10.1046/j.1471-4159.2002.00902.x [eCite] [Details]

Citations: Scopus - 37Web of Science - 35

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2001Nunan J, Shearman MS, Checler F, Cappai R, Evin G, et al., 'The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase', European Journal of Biochemistry: The Febs Journal, 268, (20) pp. 5329-5336. ISSN 0014-2956 (2001) [Refereed Article]

DOI: 10.1046/j.0014-2956.2001.02465.x [eCite] [Details]

Citations: Scopus - 107Web of Science - 104

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2001Saez-Valero J, Mok SS, Small DH, 'An unusually glycosylated form of acetylcholinesterase is a CSF biomarker for Alzheimer's disease', Acta Neurologica Scandinavica. Supplementum, 176 pp. 49-52 . ISSN 0065-1427 (2001) [Refereed Article]

DOI: 10.1034/j.1600-0404.2000.00307.x [eCite] [Details]

Citations: Web of Science - 14

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2001Saez-Valero J, Small DH, 'Altered glycosylation of cerebrospinal fluid butyrylcholinesterase in Alzheimer's disease', Brain Research, 889, (1-2) pp. 247-250. ISSN 0006-8993 (2001) [Refereed Article]

DOI: 10.1016/S0006-8993(00)03144-9 [eCite] [Details]

Citations: Scopus - 16Web of Science - 12

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2001Saez-Valero J, Small DH, 'Acetylcholinesterase and butyrylcholinesterase glycoforms are biomarkers of Alzheimer's disease', Journal of Alzheimer's Disease, 3, (3) pp. 323-328. ISSN 1387-2877 (2001) [Refereed Article]

[eCite] [Details]

2001Small DH, Mok SS, Bornstein JC, 'Alzheimer's disease and Aβ toxicity: from top to bottom', Nature Reviews Neuroscience, 2 pp. 595-598. ISSN 1471-003X (2001) [Refereed Article]

[eCite] [Details]

2001Fodero LR, Saez-Valero J, Barquero MS, Marcos A, McLean CA, et al., 'Wheat germ agglutinin-binding glycoproteins are decreased in Alzheimer's disease cerebrospinal fluid', Journal of Neurochemistry, 79, (5) pp. 1022-1026. ISSN 0022-3042 (2001) [Refereed Article]

DOI: 10.1046/j.1471-4159.2001.00640.x [eCite] [Details]

Citations: Scopus - 29Web of Science - 26

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2000Postuma RB, He WL, Nunan J, Beyreuther K, Masters CL, et al., 'Substrate-bound beta-amyloid peptides inhibit cell adhesion and neurite outgrowth in primary neuronal cultures', Journal of Neurochemistry, 74, (3) pp. 1122-1130. ISSN 0022-3042 (2000) [Refereed Article]

DOI: 10.1046/j.1471-4159.2000.741122.x [eCite] [Details]

Citations: Scopus - 44Web of Science - 44

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2000Saez-Valero J, Barquero MS, Marcos A, McLean CA, Small DH, 'Altered glycosylation of acetylcholinesterase in lumbar cerebrospinal fluid of patients with Alzheimer's disease', Journal of Neurology, Neurosurgery and Psychiatry, 69, (5) pp. 664-667. ISSN 0022-3050 (2000) [Refereed Article]

DOI: 10.1136/jnnp.69.5.664 [eCite] [Details]

Citations: Scopus - 33Web of Science - 34

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1999Cappai R, Mok SS, Galatis D, Tucker DF, Henry A, et al., 'Recombinant human amyloid precursor-like protein 2 (APLP2) expressed in the yeast Pichia pastoris can stimulate neurite outgrowth', F E B S Letters: (Federation of European Biochemical Societies), 442, (1) pp. 95-98. ISSN 0014-5793 (1999) [Refereed Article]

DOI: 10.1016/S0014-5793(98)01635-4 [eCite] [Details]

Citations: Scopus - 46Web of Science - 46

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1999Caswell MD, San Mok S, Henry A, Cappai R, Klug G, et al., 'The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons', European Journal of Biochemistry: The Febs Journal, 266, (2) pp. 509-516. ISSN 0014-2956 (1999) [Refereed Article]

DOI: 10.1046/j.1432-1327.1999.00886.x [eCite] [Details]

Citations: Scopus - 13Web of Science - 12

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1999Saez-Valero J, Sberna G, McLean CA, Small DH, 'Molecular isoform distribution and glycosylation of acetylcholinesterase are altered in brain and cerebrospinal fluid of patients with Alzheimer's disease', Journal of Neurochemistry, 72, (4) pp. 1600-1608. ISSN 0022-3042 (1999) [Refereed Article]

DOI: 10.1046/j.1471-4159.1999.721600.x [eCite] [Details]

Citations: Scopus - 84Web of Science - 82

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1999Yang DS, Small DH, Seydel U, Smith JD, Hallmayer J, et al., 'Apolipoprotein E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner', Neuroscience: An International Journal, 90, (4) pp. 1217-1226. ISSN 0306-4522 (1999) [Refereed Article]

DOI: 10.1016/S0306-4522(98)00561-2 [eCite] [Details]

Citations: Scopus - 89Web of Science - 88

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1998Moir RD, Lynch T, Bush AI, Whyte S, Henry A, et al., 'Relative increase in Alzheimer's disease of soluble forms of cerebral A beta amyloid protein precursor containing the Kunitz protease inhibitory domain', Journal of Biological Chemistry, 273, (9) pp. 5013-5019. ISSN 0021-9258 (1998) [Refereed Article]

DOI: 10.1074/jbc.273.9.5013 [eCite] [Details]

Citations: Scopus - 83Web of Science - 88

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1998Postuma RB, Martins RN, Cappai R, Beyreuther K, Masters CL, et al., 'Effects of the amyloid protein precursor of Alzheimer's disease and other ligands of the LDL receptor-related protein on neurite outgrowth from sympathetic neurons in culture', F E B S Letters: (Federation of European Biochemical Societies), 428, (1-2) pp. 13-16. ISSN 0014-5793 (1998) [Refereed Article]

DOI: 10.1016/S0014-5793(98)00475-X [eCite] [Details]

Citations: Scopus - 26Web of Science - 25

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1998Sberna G, Saez-Valero J, Li QX, Czech C, Beyreuther K, et al., 'Acetylcholinesterase is increased in the brains of transgenic mice expressing the C-terminal fragment (CT100) of the beta-amyloid protein precursor of Alzheimer's disease', Journal of Neurochemistry, 71, (2) pp. 723-731. ISSN 0022-3042 (1998) [Refereed Article]

DOI: 10.1046/j.1471-4159.1998.71020723.x [eCite] [Details]

Citations: Web of Science - 89

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1997Clarris HJ, Cappai R, Heffernan D, Beyreuther K, Masters CL, et al., 'Identification of heparin-binding domains in the amyloid precursor protein of Alzheimer's disease by deletion mutagenesis and peptide mapping', Journal of Neurochemistry, 68, (3) pp. 1164-1172. ISSN 0022-3042 (1997) [Refereed Article]

DOI: 10.1046/j.1471-4159.1997.68031164.x [eCite] [Details]

Citations: Web of Science - 62

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1997Mok SS, Evin G, Li QX, Smith AI, Beyreuther K, et al., 'A novel metalloprotease in rat brain cleaves the amyloid precursor protein of Alzheimer's disease generating amyloidogenic fragments', Biochemistry, 36, (1) pp. 156-163. ISSN 0006-2960 (1997) [Refereed Article]

DOI: 10.1021/bi961848w [eCite] [Details]

Citations: Scopus - 18Web of Science - 17

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1997Mok SS, Sberna G, Heffernan D, Cappai R, Galatis D, et al., 'Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease', F E B S Letters: (Federation of European Biochemical Societies), 415, (3) pp. 303-307. ISSN 0014-5793 (1997) [Refereed Article]

DOI: 10.1016/S0014-5793(97)01146-0 [eCite] [Details]

Citations: Scopus - 46Web of Science - 46

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1997Saez-Valero J, Sberna G, McLean CA, Masters CL, Small DH, 'Glycosylation of acetylcholinesterase as diagnostic marker for Alzheimer's disease', The Lancet, 350 pp. 929. ISSN 0140-6736 (1997) [Letter or Note in Journal]

[eCite] [Details]

1997Sberna G, Saez-Valero J, Beyreuther K, Masters CL, Small DH, 'The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells', Journal of Neurochemistry, 69, (3) pp. 1177-1184. ISSN 0022-3042 (1997) [Refereed Article]

DOI: 10.1046/j.1471-4159.1997.69031177.x [eCite] [Details]

Citations: Web of Science - 101

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1996Williamson TG, Mok SS, Henry A, Cappai R, Lander AD, et al., 'Secreted Glypican Binds to the Amyloid Precursor Protein of Alzheimer's Disease (APP) and Inhibits APP-induced Neurite Outgrowth', Journal of Biological Chemistry, 271, (49) pp. 31215-31221. ISSN 0021-9258 (1996) [Refereed Article]

DOI: 10.1074/jbc.271.49.31215 [eCite] [Details]

Citations: Scopus - 83Web of Science - 85

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1995Brickman YG, Ford MD, Small DH, Bartlett PF, Nurcombe V, 'Heparan sulfates mediate the binding of basic fibroblast growth factor to a specific receptor on neural precursor cells', Journal of Biological Chemistry, 270, (42) pp. 24941-24948. ISSN 0021-9258 (1995) [Refereed Article]

DOI: 10.1074/jbc.270.42.24941 [eCite] [Details]

Citations: Scopus - 86Web of Science - 81

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1995LePage RN, Fosang AJ, Fuller SJ, Murphy G, Evin G, et al., 'Gelatinase A possesses a beta-secretase-like activity in cleaving the amyloid protein precursor of Alzheimer's disease', F E B S Letters: (Federation of European Biochemical Societies), 377, (2) pp. 267-270. ISSN 0014-5793 (1995) [Refereed Article]

DOI: 10.1016/0014-5793(95)01358-X [eCite] [Details]

Citations: Scopus - 32Web of Science - 35

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1995Li QX, Evin G, Small DH, Multhaup G, Beyreuther K, et al., 'Proteolytic Processing of Alzheimers-Disease Beta-A4 Amyloid Precursor Protein in Human Platelets', Journal of Biological Chemistry, 270, (23) pp. 14140-14147. ISSN 0021-9258 (1995) [Refereed Article]

DOI: 10.1074/jbc.270.23.14140 [eCite] [Details]

Citations: Scopus - 87Web of Science - 90

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1995Small DH, 'A function for butyrylcholinesterase', Journal of Neurochemistry , 64, (1) pp. 466-467. ISSN 0022-3042 (1995) [Letter or Note in Journal]

DOI: 10.1046/j.1471-4159.1995.64010466.x [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

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1995Evin G, Cappai R, Li QX, Culvenor JG, Small DH, et al., 'Candidate Gamma-Secretases in the Generation of the Carboxyl-Terminus of the Alzheimers-Disease Beta-A4 Amyloid - Possible Involvement Of Cathepsin-D', Biochemistry, 34, (43) pp. 14185-14192. ISSN 0006-2960 (1995) [Refereed Article]

DOI: 10.1021/bi00043a024 [eCite] [Details]

Citations: Scopus - 71Web of Science - 77

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1995Williamson TG, Nurcombe V, Beyreuther K, Masters CL, Small DH, 'Affinity Purification of Proteoglycans that bind to the Amyloid Protein Precursor of Alzheimers Disease', Journal of Neurochemistry, 65, (5) pp. 2201-2208. ISSN 0022-3042 (1995) [Refereed Article]

DOI: 10.1046/j.1471-4159.1995.65052201.x [eCite] [Details]

Citations: Scopus - 34Web of Science - 32

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1995Small DH, Reed G, Whitefield B, Nurcombe V, 'Cholinergic Regulation of Neurite Outgrowth from Isolated Chick Sympathetic Neurons in Culture', Journal of Neuroscience, 15, (1) pp. 144-151. ISSN 0270-6474 (1995) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 126

1994Small DH, Nurcombe V, Reed G, Clarris H, Moir R, et al., 'A Heparin-binding Domain in the Amyloid Protein Precursor of Alzheimer's Disease Is Involved in the Regulation of Neurite Outgrowth', Journal of Neuroscience, 14, (4) pp. 2117-2127. ISSN 0270-6474 (1994) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 306

1993Bush AI, Multhaup G, Moir RD, Williamson TG, Small DH, et al., 'A novel zinc(II) binding site modulates the function of the beta-A4 amyloid protein precursor of Alzheimer's disease', Journal of Biological Chemistry, 268, (22) pp. 16109-16112. ISSN 0021-9258 (1993) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 239

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1993Cheung NS, Small DH, Livett BG, 'An amyloid peptide beta-A4 25-35, mimics the function of substance P on modulation of nicotine-evoked secretion and desensitization in cultured bovine adrenal chromaffin cells', Journal of Neurochemistry, 60, (3) pp. 1163-1166. ISSN 0022-3042 (1993) [Refereed Article]

DOI: 10.1111/j.1471-4159.1993.tb03270.x [eCite] [Details]

Citations: Scopus - 33Web of Science - 34

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1992Bush AI, Whyte S, Thomas LD, Williamson TG, Van Tiggelen CV, et al., 'An abnormality of plasma amyloid protein precursor in Alzheimer's disease', Annals of Neurology, 32, (1) pp. 57-65. ISSN 0364-5134 (1992) [Refereed Article]

DOI: 10.1002/ana.410320110 [eCite] [Details]

Citations: Scopus - 50Web of Science - 59

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1992Milward EA, Papadopoulos R, Fuller SJ, Moir RD, Small D, et al., 'The Amyloid Protein Precursor of Alzheimer's Disease Is a Mediator of the Effects of Nerve Growth Factor on Neurite Outgrowth', Neuron, 9 pp. 129-137. ISSN 0896-6273 (1992) [Refereed Article]

[eCite] [Details]

1992Moir RD, Martins RN, Small DH, Bush AI, Milward EA, et al., 'Human brain beta-A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization. ', Journal of Neurochemistry, 59, (4) pp. 1490-1498. ISSN 0022-3042 (1992) [Refereed Article]

DOI: 10.1111/j.1471-4159.1992.tb08465.x [eCite] [Details]

Citations: Scopus - 45Web of Science - 50

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1992Small DH, Nurcombe V, Moir R, Michaelson S, Monard D, et al., 'Association and Release of the Amyloid Protein Precursor of Alzheimer's Disease from Chick Brain Extracellular Matrix', Journal of Neuroscience, 12, (11) pp. 4143-4150. ISSN 0270-6474 (1992) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 80

1991Small DH, Moir RD, Fuller S, Michaelson S, Bush AI, et al., 'A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer's disease', Biochemistry, 30, (44) pp. 10795-10799. ISSN 0006-2960 (1991) [Refereed Article]

DOI: 10.1021/bi00108a027 [eCite] [Details]

Citations: Scopus - 64Web of Science - 69

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1988Kecorius E, Small DH, Livett BG, 'Characterization of a dipeptidyl aminopeptidase from bovine adrenal medulla', Journal of Neurochemistry, 50, (1) pp. 38-44 . ISSN 0022-3042 (1988) [Refereed Article]

DOI: 10.1111/j.1471-4159.1988.tb13226.x [eCite] [Details]

Citations: Scopus - 8Web of Science - 9

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1988Small DH, Chubb IW, 'Identification of a trypsin-like site associated with acetylcholinesterase by affinity labelling with [H-3] diisopropyl fluorophosphate', Journal of Neurochemistry, 51, (1) pp. 69-74. ISSN 0022-3042 (1988) [Refereed Article]

DOI: 10.1111/j.1471-4159.1988.tb04836.x [eCite] [Details]

Citations: Scopus - 16Web of Science - 17

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1985Small DH, Wurtman RJ, 'Binding of [H-3] serotonin to skeletal muscle actin', Journal of Neurochemistry, 45, (3) pp. 819-824. ISSN 0022-3042 (1985) [Refereed Article]

DOI: 10.1111/j.1471-4159.1985.tb04067.x [eCite] [Details]

Citations: Scopus - 8Web of Science - 11

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1985Small DH, Wurtman RJ, 'Association of serotonin, dopamine, or noradrenaline with an actin-like component in pheochromocytoma (PC12) cells', Journal of Neurochemistry, 45, (3) pp. 825-831. ISSN 0022-3042 (1985) [Refereed Article]

DOI: 10.1111/j.1471-4159.1985.tb04068.x [eCite] [Details]

Citations: Scopus - 6Web of Science - 7

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1984Small DH, Wurtman RJ, 'Serotonin binds specifically and saturably to an actin-like protein isolated from rat brain synaptosomes', National Academy of Sciences of The United States of America. Proceedings, 81, (3) pp. 959-963. ISSN 0027-8424 (1984) [Refereed Article]

DOI: 10.1073/pnas.81.3.959 [eCite] [Details]

Citations: Scopus - 19Web of Science - 21

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1982Small DH, Carnegie PR, 'In Vivo Methylation of an Arginine in Chicken Myelin Basic Protein', Journal of Neurochemistry, 38, (1) pp. 184-190. ISSN 0022-3042 (1982) [Refereed Article]

DOI: 10.1111/j.1471-4159.1982.tb10870.x [eCite] [Details]

Citations: Scopus - 16Web of Science - 18

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Chapter in Book

(5 outputs)
YearCitationAltmetrics
2014Aguilar M-I, Hou X, Losic D, Mechler AI, Martin LL, et al., 'Single-Molecule Imaging of Amyloid-β Protein (Aβ) of Alzheimer's Disease: From Single-Molecule Structures to Aggregation Mechanisms and Membrane Interactions', Bio-nanoimaging: Protein Misfolding & Aggregation, Elsevier, Uversky VN and Lyubchenko YL (ed), United States of America, pp. 47-56. ISBN 978-0-12-394431-3 (2014) [Research Book Chapter]

DOI: 10.1016/B978-0-12-394431-3.00005-5 [eCite] [Details]

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2012Gasperini RJ, Klaver DW, Hou X, Aguilar MI, Small DH, 'Mechanisms of Transthyretin Aggregation and Toxicity', Protein Aggregation and Fibrillogenesis in Cerebral and Systematic Amyloid Disease, Subcellular Biochemistry 65, Springer, JR Harris (ed), Dordrecht, pp. 211-224. ISBN 978-94-007-5415-7 (2012) [Research Book Chapter]

DOI: 10.1007/978-94-007-5416-4_9 [eCite] [Details]

Citations: Scopus - 3

Co-authors: Gasperini RJ

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2010Hou X, Small DH, Aguilar MI, 'Surface Plasmon Resonance Spectroscopy in Determination of the Interactions Between Amyloid β Proteins (Aβ) and Lipid Membranes ', Methods in Molecular Biology: Surface Plasmon Resonance, Humana Press, NJ de Mol and MJE Fischer (ed), New York, pp. 225-235. ISBN 978-1-60761-669-6 (2010) [Other Book Chapter]

DOI: 10.1007/978-1-60761-670-2_15 [eCite] [Details]

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2007Ng J, Aguilar MI, Small DH, 'Amyloid Toxicity, Synaptic Dysfunction, and the Biochemistry of Neurodegeneration in Alzheimer's Disease', Abeta Peptide and Alzheimer's Disease - Celebrating a Century of Research, Springer, Barrow CJ and Small DH (ed), London, pp. 93-101. ISBN 978-1-85233-961-6 (2007) [Research Book Chapter]

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2007Small DH, Barrow CJ, 'A Brief Introduction to the History of the β-Amyloid Protein of Alzheimer's Disease', Abeta Peptide and Alzheimer's Disease, Springer, C.J Barrow & D.H Small (ed), London, pp. 1-4. ISBN 978-1-85233-961-6 (2007) [Research Book Chapter]

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Review

(3 outputs)
YearCitationAltmetrics
2008Small DH, 'Network dysfunction in Alzheimer's disease: does synaptic scaling drive disease progression?', Trends in Molecular Medicine, 14, (3) pp. 103-108. (2008) [Substantial Review]

DOI: 10.1016/j.molmed.2007.12.006 [eCite] [Details]

Citations: Scopus - 63Web of Science - 58

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2008Small DH, Klaver DW, Beckman M, 'Regulation of proBACE1 by glycosaminoglycans', Neurodegenerative Diseases, 5, (3-4) pp. 206-208. (2008) [Review Several Works]

DOI: 10.1159/000113703 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

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1981Small DH, Carnegie PR, 'Myelopathy associated with vitamin B12 deficiency - new approaches to an old problem', Trends in Neuroscience, 4 pp. X-XI. (1981) [Review Several Works]

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Conference Publication

(14 outputs)
YearCitationAltmetrics
2014Bolos M, Hu Y, Foa L, Young K, Small D, 'The role of Neurogenin2 in APP-stimulated neural stem or progenitor cell differentiation', 34th Annual Meeting Australasian Neuroscience Society, January, Adelaide, Australia (2014) [Conference Extract]

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Co-authors: Bolos M; Hu Y; Foa L; Young K

2014Hu Y, Bolos M, Dawkins E, Foa L, Young K, et al., 'Cystatin C regulates neural stem or progenitor cell proliferation (Poster)', 34th Annual Meeting Australasian Neuroscience Society, January, Adelaide, Australia (2014) [Conference Extract]

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Co-authors: Hu Y; Bolos M; Dawkins E; Foa L; Young K

2014Bolos M, Hu Y, Foa L, Young KM, Small DH, 'APP regulates neural stem or progenitor cell differentiation through neurogenin 2 expresssion', Federation of European Neuroscience Societies, 5-9 July, Milan, Italy (2014) [Conference Extract]

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Co-authors: Bolos M; Hu Y; Foa L; Young KM

2013Dawkins E, Vincent AJ, Gasperini R, Cui H, Young K, et al., 'A direct interaction of Aβ with anionic cellular lipids mediates binding to neurons (Poster)', 12th International Conference on Alzheimer's and Parkinson's Diseases, Florence, Italy (2013) [Conference Extract]

[eCite] [Details]

Co-authors: Dawkins E; Vincent AJ; Gasperini R; Cui H; Young K; Foa L

2013Hu Y, Hung AC, Cui H, Dawkins E, Foa L, et al., 'APP stimulates neural stem/progenitor cell proliferation by increasing cystatin C secretion. (Poster)', 33rd Annual Meeting Australian Neuroscience Society, January, Melbourne, Australia (2013) [Conference Extract]

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Co-authors: Hu Y; Hung AC; Cui H; Dawkins E; Foa L; Young KM

2012Cui H, Hung AC, Freeman C, Narkowicz CK, Jacobson GA, et al., 'Effects of glycosaminoglycans on the level of β- and α-secretase and APP processing in Tg2576 primary cortical cells', APSN 2012, 29 September - 2 October, 2012, Kobe, Japan (2012) [Conference Extract]

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Co-authors: Cui H; Hung AC; Narkowicz CK; Jacobson GA

2012Cui H, Hung AC, Narkowicz CK, Jacobson GA, Small DH, 'Effects of glycosaminoglycans on the level of β- and α-secretase and APP processing in Tg2576 primary cortical cells', Australian Neuroscience Society Annual Meeting, 29 January - 1 February, 2012, Gold Coast, Australia (2012) [Conference Extract]

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Co-authors: Cui H; Hung AC; Narkowicz CK; Jacobson GA

2012Dawkins EA, Gasperini R, Vincent AJ, Foa LC, Small DH, 'Analysis of Aβ cell interactions and uptake in hippocampal culture', Proceedings of the 32nd Annual Meeting of the Australian Neuroscience Society, 29 January - 1 February 2012, Gold Coast, Australia, pp. 34. (2012) [Conference Extract]

[eCite] [Details]

Co-authors: Dawkins EA; Gasperini R; Vincent AJ; Foa LC

2011Cui H, Hung AC, Klaver D, Narkowicz CK, Jacobson GA, et al., 'Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice', Australian Neuroscience Society 31st Annual Meeting, 31 January - 3 February, 2011, Auckland, New Zealand (2011) [Conference Extract]

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Co-authors: Cui H; Hung AC; Klaver D; Narkowicz CK; Jacobson GA

2011Hadrill CE, Gasperini RJ, Dickson TC, Foa LC, Small DH, 'Regulation of the cell adhesion molecule, L1CAM by the Aβ peptide of Alzheimer's Disease', Australian Neuroscience Society 31st Annual Meeting, 31 Jan - 3 Feb, Auckland, New Zealand (2011) [Conference Extract]

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Co-authors: Hadrill CE; Gasperini RJ; Dickson TC; Foa LC

2011Hoang T, Gasperini RJ, Cui H, Shepherd CE, Strickland DK, et al., 'Interaction of the receptor-associated protein (RAP) with APP and Aβ', Australian Neuroscience Society 31st Annual Meeting, 31 Jan - 3 Feb, Auckland, New Zealand (2011) [Conference Extract]

[eCite] [Details]

Co-authors: Hoang T; Gasperini RJ; Cui H; Foa LC

2011Landowski LM, Gasperini RJ, Small DH, Taylor BVM, West AK, et al., 'Metallothionein I/II and metallothionein III induce growth cone chemotaxis via disparate mechanisms', Australian Neuroscience Society 31st Annual Meeting, 31 Jan - 3 Feb, Auckland, New Zealand (2011) [Conference Extract]

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Co-authors: Landowski LM; Gasperini RJ; Taylor BVM; West AK; Foa LC

2011Mitchell C, Gasperini RJ, Small DH, Foa LC, 'STIM1 is necessary for regulation of growth cone motility', Australian Neuroscience Society 31st Annual Meeting, 31 Jan - 3 Feb, Auckland, New Zealand (2011) [Conference Extract]

[eCite] [Details]

Co-authors: Gasperini RJ; Foa LC

2011Small DH, Klaver D, Liu S, Cui H, Hoang T, et al., 'Disruption of protein trafficking in Alzheimer's Disease: APP, Aβ and AMPA receptors', Australian Neuroscience Society 31st Annual Meeting, 31 Jan - 3 Feb, Auckland, New Zealand (2011) [Conference Extract]

[eCite] [Details]

Co-authors: Klaver D; Liu S; Cui H; Hoang T; Gasperini RJ; Foa LC

Entry

(1 outputs)
YearCitationAltmetrics
2016Southam K, Stennard FA, Small DH, 'App', Encyclopedia of Signaling Molecules, S Choi (ed), pp. 1-8 (2016) [Entry]

DOI: 10.1007/978-1-4614-6438-9_101532-1 [eCite] [Details]

Co-authors: Southam K; Stennard FA

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Grants & Funding

Prof Smalls outstanding contribution to the field has been well recognised through continuous NHMRC project/program grant funding since 1990.

Funding Summary

Number of grants

14

Total funding

$5,148,541

Projects

Are microglia the villains of AB toxicity in Alzheimer's disease (2015 - 2016)$110,000
Description
The project will create new knowledge into the role that microglia play in the development of Alzheimer's disease.
Funding
Dementia Australia Research Foundation Ltd ($110,000)
Scheme
Fellowship-Postdoctoral Fellowship in Dementia
Administered By
University of Tasmania
Research Team
Southam K; Small DH; Vincent AJ
Period
2015 - 2016
Establishment of a digital transmission electron microscopy facility (2014)$380,000
Description
Transmission electron microscopy is a fundamental tool for the study of biological systems at the ultrastructural level. Tasmania has only one, aged and barely functioning electron microscopy facility. This proposal is to establish a State-wide facility that will be accessible to a range of biological researchers across Tasmania, as well as the CSIRO and Antarctic Division. The proposed instrument will be established in new purpose-built laboratory space in the UTAS Medical Sciences Precinct, and will be supported by the Central Science Laboratory. The instrument will revitalise cellular research in Tasmania, and provide additional insights and outcomes related to the study of intracellular features in a diverse range of systems and models.
Funding
Australian Research Council ($380,000)
Scheme
Grant-Linkage Infrastructure
Administered By
University of Tasmania
Research Team
Vickers JC; Small DH; Nowak BF; Hilder EF; Hallegraeff GM
Year
2014
Grant Reference
LE140100174
Transient receptor potential channels, calcium and Alzheimer's disease (2013 - 2015)$390,758
Funding
National Health & Medical Research Council ($390,758)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Small DH; Foa LC; Vickers JC; Parkington H; Coleman Harry
Period
2013 - 2015
Grant Reference
1042566
Establishing a state-of-the-art 'Live Cell Recording and Imaging Facility' at Menzies Research Institute Tasmania (2013)$22,000
Funding
Rebecca L Cooper Medical Research Foundation ($22,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Young Kaylene; Small DH; Foa LC; Dickson TC
Year
2013
The role of store-operated calcium entry in neuronal development (2012 - 2014)$341,175
Funding
National Health & Medical Research Council ($341,175)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Foa LC; Small DH; Gell DA
Period
2012 - 2014
Grant Reference
1024145
Understanding the cause of Alzheimer's disease (2012)$177,325
Funding
National Health & Medical Research Council ($177,325)
Scheme
Grant-Dementia Seed Funding
Administered By
University of Tasmania
Research Team
Small DH; Foa LC; Vickers JC
Year
2012
Grant Reference
1020843
Biochemical studies on amyloid diseases (2011 - 2015)$630,505
Funding
National Health & Medical Research Council ($630,505)
Scheme
Fellowship-Research
Administered By
University of Tasmania
Research Team
Small DH
Period
2011 - 2015
Grant Reference
1002473
Oligodendrocyte Progenitor Cells - A new target for Alzheimer's Disease Treatment (2011 - 2013)$442,777
Funding
Bupa Foundation/Alzheimer's Society ($442,777)
Scheme
Grant-Specialist Research
Administered By
University of Tasmania
Research Team
Young Kaylene; Small DH
Period
2011 - 2013
Multidimensional analysis of biomarkers for the early detection of Alzheimer's disease using in vivo MRS (2011)$45,600
Funding
The Mason Foundation ($45,600)
Scheme
Grant-Judith Jane Mason & Harold Stannett Williams
Administered By
University of Tasmania
Research Team
Small DH; Edwards LM; Foa LC
Year
2011
The receptor-associated protein (RAP) as a molecular chaperone for the amyloid protein (Abeta) of Alzheimer's disease (2010 - 2012)$388,526
Funding
National Health & Medical Research Council ($388,526)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Small DH; Aguilar M; Shepherd Claire; Strickland D
Period
2010 - 2012
Grant Reference
605530
How amyloid causes neurodegeneration: the role of transthyretin in familial amyloidotic polyneuropathy (2009 - 2011)$594,375
Funding
National Health & Medical Research Council ($594,375)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Small DH; Parkington H; Cheung NS; Aguilar M; Coleman H
Period
2009 - 2011
Grant Reference
544920
Regulation of the beta-secretase (BACE1) by glycosaminoglycans (2008 - 2010)$539,250
Funding
National Health & Medical Research Council ($539,250)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Small DH; Vickers JC; West AK
Period
2008 - 2010
Grant Reference
490031
Establishment of a Confocal/multiphoton Microscope for Imaging of Living Systems (2008)$300,000
Funding
Australian Research Council ($300,000)
Scheme
Grant-Linkage Infrastructure
Administered By
University of Tasmania
Research Team
Vickers JC; Foote SJ; Small DH; Walters EH; Hallegraeff GM; West AK; Chung RS; Woods GM; Dickson TC; Nowak BF; Bolch CJS
Year
2008
Grant Reference
LE0882701
David Small Research Fellowship - SRF B (2005 - 2010)$786,250
Funding
National Health & Medical Research Council ($786,250)
Scheme
Fellowship-Research
Administered By
National Health & Medical Research Council
Research Team
Small DH
Period
2005 - 2010
Grant Reference
334035

Research Supervision

Prof Small has successfully supervised more than 12 PhD candidates and over 20 honours students to completion.

Completed

5

Completed

DegreeTitleCompleted
PhDRole of Amyloid Precursor Protein in Neural Stem/Progenitor Cell Proliferation and Differentiation
Candidate: Yanling Hu
2016
PhDRole of Phosphoinositides in the Biology of the Amyloid Precursor Protein
Candidate: Edgar Adam Henry Dawkins
2014
PhDSTIM1 Mediates Multiple Signalling Pathways in Neuronal Growth Cones
Candidate: Camilla Bessie Mitchell
2013
PhDStudies on the Use of Glycosaminoglycans for the Treatment of Alzheimer's Disease
Candidate: Hao Cui
2012
MastersRole of the 39-kDa Receptor-Associated Protein (RAP) in Alzheimer's Disease
Candidate: Thanh Hoang
2012