Profiles

Michelle Keske

UTAS Home Dr Michelle Anne Keske (nee Vincent)

Michelle Anne Keske (nee Vincent)

Senior Research Fellow
Menzies Institute for Medical Research

Room 436d, Medical Science 2, Hobart CBD Campuses

+61 3 6226 2669 (phone)

Michelle.Keske@utas.edu.au

Dr Keske's research focuses on the effect of pharmacological and nutritional interventions that can help prevent insulin resistance and type 2 diabetes by regulating microvascular blood flow within muscle.

Obesity, hypertension and type 2 diabetes, which are increasing to epidemic proportions in Australia, are major risk factors for cardiovascular disease. A common feature of these conditions is insulin resistance which is characterised by impaired insulin-mediated glucose metabolism in muscle.

Dr Keske's research has shown that microvascular function in muscle plays an integral role in blood glucose regulation. Insulin increases microvascular perfusion in muscle to facilitate access of glucose and insulin to the myocyte to enhance glucose disposal. Impairment in insulin-mediated microvascular perfusion in muscle can lead to insulin resistance and type 2 diabetes.

Career summary

Qualifications

  • PhD, University of Tasmania, Australia, 2000. Vascular effects of vasoconstrictors on muscle metabolism
  • BSc (Hons), University of Tasmania, Australia, 1994. Haemodynamic basis of insulin resistance

Biography

Dr Keske has been a dedicated researcher in the diabetes and cardiovascular disease field for the past 15 years. She received her PhD from the Diabetes Research Group (formerly known as the Department of Biochemistry), University of Tasmania in December 2000. During her PhD she had the opportunity to work as a visiting scholar at the University of Washington, Seattle, WA, USA. She completed 8 years of international post-doctoral training at the University of Virginia, National Institutes of Health, and Industry in the USA.

In 2007 she was recruited to join the Menzies Institute for Medical Research. She now leads a research group studying novel pharmaceutical and nutritional interventions that have the potential to prevent or reverse vascular defects in patients with diabetes and cardiovascular disease.

Research Themes

Dr Keske's research aligns to the University's research theme of Better Health. Obesity, hypertension and type 2 diabetes, which are increasing to epidemic proportions in Australia, are major risk factors for cardiovascular disease. A common feature of these conditions is insulin resistance which is characterised by impaired insulin-mediated glucose metabolism in muscle.

Dr Keske is researching into the vascular causes and consequences of insulin resistance. She is working on targeting the vasculature in skeletal muscle as a novel treatment target for preventing or reversing the development of insulin resistance.

Memberships

Professional practice

  • American Diabetes Association
  • Australian Diabetes Society
  • Australian Society for Medical Research

Administrative expertise

  • Member of the Menzies Institute of Medical Research, UTAS (2007-ongoing)
  • Chair of the animal users group committee, Menzies Institute of Medical Research, UTAS (2011-2013)
  • Coordinator of Menzies Institute of Medical Research Seminar Series (2012-2013)
  • Member of the phase 2 planning committee for the Menzies Research Institute Tasmania Medical Science Building 2, UTAS
  • UROP selection committee (2010)
  • Member of the Menzies Institute of Medical Research, UTAS mentoring program (2010)
  • Coordinator of Human Genetics and Population Health Courses (2014-current)
  • Member of Menzies Institute of Medical Research Senior Management Team (2014)

Teaching

Teaching expertise

  • Supervise 10 week research projects for 3rd year undergraduate Biochemistry students
  • Ultrasound imaging practical for 3rd year undergraduate Physiology students

Teaching responsibility

Research Appointments

  • Invited expert at the Omega-3 Centre, Scientific Consensus panel in North Ryde, NSW, July 2008
  • Board of Directors for Diabetes Tasmania (2015-current)
  • Panel Member NHMRC Project Grants GRP3B (2014)
  • Panel Member NHMRC Project Grants GRP3C (2015)

Research Invitations

Invited presentations over past 5 years:

  • Methods for the investigation of flowmotion. World Congress of Microcirculation, Kyoto, Japan, Sept 2015
  • Exercise in the management and prevention of metabolic disease: Vascular actions of insulin and contraction in skeletal muscle. Victoria University, Melbourne, June 2015
  • Normal function of the skeletal muscle microvasculature and its endothelium. Exchange Symposium: Physiological Society in the UK and the European College of Sport Sciences. London, UK June 2014
  • Muscle microvascular blood flow responses in insulin resistance and aging. Exchange Symposium: Physiological Society in the UK and the European College of Sport Sciences. London, UK June 2014
  • Role of muscle blood flow on insulin action. University of Los Angeles, USA, November 2013
  • Can drinking tea enhance insulin sensitivity? Tasmanian Nutrition Society, Hobart, Sept 2013
  • Role of microvascular perfusion in insulin sensitivity. The Hobart Medical Symposium, Hobart, Australia. October 2012
  • Microcirculation and insulin resistance. The University of Aberdeen, Scotland, UK. June 2012
  • Imaging skeletal muscle microcirculation with contrast-enhanced ultrasound: diagnostic and therapeutic approaches to insulin resistance. International Conference on Clinical Research. San Francisco, CA, USA. July 2011
  • Does omega-3 DHA and omega-6 ARA play a role in microvascular regulation in skeletal muscle. DSM, Maryland, USA July 2011
  • Microcirculation and obesity. Australian and New Zealand Obesity Society. Adelaide, SA. October 2011

View more on Dr Michelle Keske in WARP

Expertise

  • Insulin Resistance
  • Type 2 diabetes
  • Cardiovascular Disease
  • Exercise
  • Nutrition
  • Ultrasound imaging

Awards

  • American Society of Echocardiography Research Award Finalist, 16th Annual Scientific Sessions, Boston, MA, USA, 2005. 'Microvascular responses to insulin are abnormal in type 2 diabetes and are reversed by ACE-inhibitor therapy: assessment of capillary recruitment by contrast ultrasound'
  • Quantum Leap Fellowship, University of Tasmania, 2008-2013 - $1M

Collaboration

International Collaborations

  • Prof Eugene Barrett, University of Virginia, Virginia, USA
  • Prof Jonathan Linder, Oregon Health & Science University, Oregon, USA
  • Assoc/Prof Melinda Moore, University of Texas Medical Branch, Texas, USA
  • Dr Ranganath Muniyappa, NIH, Maryland, USA
  • Prof Michael Quon, University of Maryland, Baltimore, Maryland, USA
  • Dr Dana Dawson, Aberdeen University, Scotland, UK
  • Prof Eric Ravussin, Pennington Biomedical Research Center, Louisiana, USA
  • Assoc/Prof Christian Roberts, UCLA, California, USA

National Collaborations

  • Prof Glenn McConell, Victoria University, Melbourne
  • Prof Bronwyn Kingwell, Baker IDI, Melbourne
  • Assoc/Prof Leonie Heilbronn, South Australian Health and Medical Research Institute, Adelaide

Current projects

  1. Microvascular dysfunction in adult offspring of type 2 diabetics
  2. Role of microvascular flowmotion in skeletal muscle glucose metabolism
  3. Cardiometabolic benefits of exercise training in type 2 diabetics independent of weight loss
  4. Can drinking blueberry tea improve metabolic and vascular health in people with type 2 diabetes?
  5. Sodium intake and microvascular-derived insulin resistance
  6. Role of high fat diets on inflammation

Fields of Research

  • Endocrinology (110306)
  • Cardiology (incl. Cardiovascular Diseases) (110201)
  • Systems Physiology (111603)
  • Peripheral Nervous System (110905)
  • Animal Physiology - Systems (060603)
  • Medical Biotechnology (100499)
  • Preventive Medicine (111716)
  • Medical Biochemistry: Carbohydrates (110102)
  • Nutrition and Dietetics (111199)
  • Nutritional Physiology (111103)
  • Cell Metabolism (060104)
  • Exercise Physiology (110602)
  • Physiology (060699)
  • Medical Physiology (111699)
  • Epidemiology (111706)
  • Public Nutrition Intervention (111104)
  • Basic Pharmacology (111501)
  • Medical Biochemistry: Amino Acids and Metabolites (110101)
  • Complementary and Alternative Medicine (110499)
  • Geriatrics and Gerontology (110308)
  • Clinical Pharmacology and Therapeutics (111502)
  • Proteins and Peptides (030406)
  • Neurology and Neuromuscular Diseases (110904)
  • Foetal Development and Medicine (111401)
  • Sensory Systems (110906)
  • Sports Medicine (110604)
  • Central Nervous System (110903)
  • Neurosciences (110999)
  • Animal Physiology - Biophysics (060601)
  • Medical and Health Sciences (119999)

Research Objectives

  • Diabetes (920104)
  • Cardiovascular System and Diseases (920103)
  • Nervous System and Disorders (920111)
  • Health (929999)
  • Preventive Medicine (920412)
  • Nutrition (920411)
  • Human Diagnostics (860802)
  • Human Pharmaceutical Treatments (e.g. Antibiotics) (860803)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Clinical Health (Organs, Diseases and Abnormal Conditions) (920199)
  • Expanding Knowledge in the Environmental Sciences (970105)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Behaviour and Health (920401)
  • Health Related to Ageing (920502)
  • Allied Health Therapies (excl. Mental Health Services) (920201)
  • Diagnostic Methods (920203)
  • Reproductive System and Disorders (920114)
  • Health Education and Promotion (920205)
  • Medical Instruments (861502)
  • Cancer and Related Disorders (920102)
  • Aboriginal and Torres Strait Islander Health - Health System Performance (incl. Effectiveness of Interventions) (920303)
  • Skin and Related Disorders (920117)
  • Public Health (excl. Specific Population Health) (920499)

Publications

Dr Keske has published 51 papers (14 as primary author, 9 as senior author) over the course of her career in highly recognized, internationally peer reviewed journals such as Diabetes, Diabetologia, Diabetes Care, JACCI,Cardiovascular Research. Her research has been cited >2,300 times (H-index = 20) and many of her publications are rated as highly influential (9 cited >100 times; 3 cited >200 times; 1 cited >300 times).

Total publications

58

Journal Article

(45 outputs)
YearCitationAltmetrics
2017Blackwood SJ, Dwyer RM, Bradley EA, Keske MA, Richards SM, et al., 'Determination of skeletal muscle microvascular flowmotion with contrast-enhanced ultrasound', Ultrasound in Medicine and Biology, 43, (9) pp. 2013-2023. ISSN 0301-5629 (2017) [Refereed Article]

DOI: 10.1016/j.ultrasmedbio.2017.05.012 [eCite] [Details]

Co-authors: Blackwood SJ; Dwyer RM; Bradley EA; Richards SM; Rattigan S

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2017Keske MA, Dwyer RM, Russell RD, Blackwood SJ, Brown Aascha, et al., 'Regulation of microvascular flow and metabolism: An overview', Clinical and Experimental Pharmacology and Physiology, 44, (1) pp. 143-149. ISSN 0305-1870 (2017) [Refereed Article]

DOI: 10.1111/1440-1681.12688 [eCite] [Details]

Co-authors: Dwyer RM; Russell RD; Blackwood SJ; Brown Aascha; Premilovac D; Richards SM; Rattigan S

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2017Russell RD, Hu D, Greenaway T, Blackwood SJ, Dwyer RM, et al., 'Skeletal Muscle Microvascular-Linked Improvements in Glycemic Control From Resistance Training in Individuals With Type 2 Diabetes', Diabetes Care, 40, (9) pp. 1256-1263. ISSN 0149-5992 (2017) [Refereed Article]

DOI: 10.2337/dc16-2750 [eCite] [Details]

Co-authors: Russell RD; Greenaway T; Blackwood SJ; Dwyer RM; Sharman JE; Jones G; Squibb KA; Brown AA; Otahal P; Al-Aubaidy H; Premilovac D; Hitchins S; Richards SM; Rattigan S

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2016Keske MA, Premilovac D, Bradley EA, Dwyer RM, Richards SM, et al., 'Muscle microvascular blood flow responses in insulin resistance and ageing', The Journal of Physiology, 594, (8) pp. 2223-2231. ISSN 1469-7793 (2016) [Refereed Article]

DOI: 10.1113/jphysiol.2014.283549 [eCite] [Details]

Citations: Scopus - 8Web of Science - 4

Co-authors: Premilovac D; Bradley EA; Dwyer RM; Richards SM; Rattigan S

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2016Wagenmakers AJM, Strauss JA, Shepherd SO, Keske MA, Cocks M, 'Increased muscle blood supply and transendothelial nutrient and insulin transport induced by food intake and exercise: effect of obesity and ageing', Journal of Physiology, 594, (8) pp. 2207-2222. ISSN 0022-3751 (2016) [Refereed Article]

DOI: 10.1113/jphysiol.2014.284513 [eCite] [Details]

Citations: Scopus - 8Web of Science - 7

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2016Climie RED, Picone DS, Keske MA, Sharman JE, 'Brachial-to-radial systolic blood pressure amplification in patients with type 2 diabetes mellitus', Journal of Human Hypertension, 30 pp. 404-409. ISSN 1476-5527 (2016) [Refereed Article]

DOI: 10.1038/jhh.2015.101 [eCite] [Details]

Co-authors: Climie RED; Picone DS; Sharman JE

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2016Ng HL, Premilovac D, Rattigan S, Richards SM, Muniyappa R, et al., 'Acute vascular and metabolic actions of the green tea polyphenol epigallocatechin 3-gallate in rat skeletal muscle', Journal of Nutritional Biochemistry, 40 pp. 23-31. ISSN 0955-2863 (2016) [Refereed Article]

DOI: 10.1016/j.jnutbio.2016.10.005 [eCite] [Details]

Co-authors: Ng HL; Premilovac D; Rattigan S; Richards SM

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2015Hong YH, Betik AC, Premilovac D, Dwyer RM, Keske MA, et al., 'No effect of NOS inhibition on skeletal muscle glucose uptake during in situ hindlimb contraction in healthy and diabetic Sprague-Dawley rats', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 308, (10) pp. R862-R871. ISSN 0363-6119 (2015) [Refereed Article]

DOI: 10.1152/ajpregu.00412.2014 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Premilovac D; Dwyer RM; Rattigan S

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2015Keske MA, Ng HLH, Premilovac D, Rattigan S, Kim J, et al., 'Vascular and metabolic actions of the green tea polyphenol epigallocatechin gallate', Current Medicinal Chemistry, 22, (1) pp. 59-69. ISSN 0929-8673 (2015) [Refereed Article]

PMID: 25312214 [eCite] [Details]

Citations: Scopus - 21Web of Science - 20

Co-authors: Ng HLH; Premilovac D; Rattigan S

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2015Picone DS, Climie RED, Ahuja KDK, Keske MA, Sharman JE, 'Brachial-to-radial SBP amplification: implications of age and estimated central blood pressure from radial tonometry', Journal of Hypertension, 33, (9) pp. 1876-1883. ISSN 0263-6352 (2015) [Refereed Article]

DOI: 10.1097/HJH.0000000000000637 [eCite] [Details]

Citations: Scopus - 13Web of Science - 16

Co-authors: Picone DS; Climie RED; Ahuja KDK; Sharman JE

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2015Sacre JW, Jellis CL, Haluska BA, Jenkins C, Coombs JS, et al., 'Association of exercise intolerance in type 2 diabetes with skeletal muscle blood flow reserve', JACC: Cardiovascular Imaging, 8, (8) pp. 913-921. ISSN 1936-878X (2015) [Refereed Article]

DOI: 10.1016/j.jcmg.2014.12.033 [eCite] [Details]

Citations: Scopus - 5Web of Science - 6

Co-authors: Marwick TH

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2015Bradley EA, Zhang L, Genders AJ, Richards SM, Rattigan S, et al., 'Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside', Cardiovascular Diabetology, 14, (1) Article 91. ISSN 1475-2840 (2015) [Refereed Article]

DOI: 10.1186/s12933-015-0251-y [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Bradley EA; Richards SM; Rattigan S

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2014Barrett EJ, Keske MA, Rattigan S, Eringa EC, 'Rebuttal from Eugene J. Barrett, Michelle A. Keske, Stephen Rattigan and Etto C. Eringa', The Journal of physiology, 592, (23) pp. 5137-5138. ISSN 0022-3751 (2014) [Contribution to Refereed Journal]

DOI: 10.1113/jphysiol.2014.284604 [eCite] [Details]

Co-authors: Rattigan S

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2014Premilovac D, Richards SM, Rattigan S, Keske MA, 'A vascular mechanism for high-sodium-induced insulin resistance in rats', Diabetologia: Clinical and Experimental Diabetes and Metabolism, 57, (12) pp. 2586-2595. ISSN 0012-186X (2014) [Refereed Article]

DOI: 10.1007/s00125-014-3373-y [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Premilovac D; Richards SM; Rattigan S

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2014Barrett EJ, Keske MA, Rattigan S, Eringa EC, 'CrossTalk proposal: De novo capillary recruitment in healthy muscle is necessary', Journal of Physiology, 592, (23) pp. 5129-5131. ISSN 0022-3751 (2014) [Refereed Article]

DOI: 10.1113/jphysiol.2014.282137 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Rattigan S

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2013Bradley EA, Richards SM, Keske MA, Rattigan S, 'Local NOS inhibition impairs vascular and metabolic actions of insulin in rat hindleg muscle in vivo', American Journal of Physiology: Endocrinology and Metabolism, 305, (6) pp. E745-E750. ISSN 0193-1849 (2013) [Refereed Article]

DOI: 10.1152/ajpendo.00289.2013 [eCite] [Details]

Citations: Scopus - 14Web of Science - 14

Co-authors: Bradley EA; Richards SM; Rattigan S

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2013Keith LJ, Rattigan S, Keske MA, Jose M, Sharman JE, 'Exercise aortic stiffness: Reproducibility and relation to end-organ damage in men', Journal of Human Hypertension, 27, (8) pp. 516-522. ISSN 0950-9240 (2013) [Refereed Article]

DOI: 10.1038/jhh.2013.5 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Keith LJ; Rattigan S; Jose M; Sharman JE

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2013Premilovac D, Bradley EA, Ng HLH, Richards SM, Rattigan S, et al., 'Muscle insulin resistance resulting from impaired microvascular insulin sensitivity in Sprague Dawley rats', Cardiovascular Research, 98, (1) pp. 28-36. ISSN 0008-6363 (2013) [Refereed Article]

DOI: 10.1093/cvr/cvt015 [eCite] [Details]

Citations: Scopus - 17Web of Science - 15

Co-authors: Premilovac D; Bradley EA; Ng HLH; Richards SM; Rattigan S

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2013Premilovac D, Roberts-Thompson KM, Ng HLH, Bradley EA, Richards SM, et al., 'Blueberry tea enhances insulin sensitivity by augmenting insulin-mediated metabolic and microvascular responses in skeletal muscle of high fat fed rats', International Journal of Diabetology & Vascular Disease Research, 1, (8) pp. 1-10. ISSN 2328-353X (2013) [Non Refereed Article]

[eCite] [Details]

Co-authors: Premilovac D; Ng HLH; Bradley EA; Richards SM; Rattigan S

2013Rattigan S, Richards SM, Keske MA, 'Microvascular contributions to insulin resistance', Diabetes, 62, (2) pp. 343-345. ISSN 0012-1797 (2013) [Contribution to Refereed Journal]

DOI: 10.2337/db12-1193 [eCite] [Details]

Citations: Scopus - 9Web of Science - 9

Co-authors: Rattigan S; Richards SM

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2012St-Pierre P, Keith LJ, Richards SM, Rattigan S, Keske MA, 'Microvascular blood flow responses to muscle contraction are not altered by high-fat feeding in rats', Diabetes, Obesity and Metabolism, 14, (8) pp. 753-761. ISSN 1462-8902 (2012) [Refereed Article]

DOI: 10.1111/j.1463-1326.2012.01598.x [eCite] [Details]

Citations: Scopus - 6Web of Science - 7

Co-authors: Keith LJ; Richards SM; Rattigan S

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2010Durham WJ, Casperson SL, Dillon EL, Keske MA, Paddon-Jones D, et al., 'Age-related anabolic resistance after endurance-type exercise in healthy humans', The FASEB Journal: (Federation of American Societies for Experimental Biology), 24, (10) pp. 4117-4127. ISSN 0892-6638 (2010) [Refereed Article]

DOI: 10.1096/fj.09-150177 [eCite] [Details]

Citations: Scopus - 40Web of Science - 36

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2010St Pierre P, Genders AJ, Keske MA, Richards SM, Rattigan S, 'Loss of insulin-mediated microvascular perfusion in skeletal muscle is associated with the development of insulin resistance ', Diabetes Obesity & Metabolism, 12, (9) pp. 798-805. ISSN 1462-8902 (2010) [Refereed Article]

DOI: 10.1111/j.1463-1326.2010.01235.x [eCite] [Details]

Citations: Scopus - 24Web of Science - 23

Co-authors: Genders AJ; Richards SM; Rattigan S

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2009Keske MA, Clerk LH, Price WJ, Jahn LA, Barrett EJ, 'Obesity Blunts Microvascular Recruitment in Human Forearm Muscle After a Mixed Meal', Diabetes Care, 32, (9) pp. 1672-1677. ISSN 0149-5992 (2009) [Refereed Article]

DOI: 10.2337/dc09-0206 [eCite] [Details]

Citations: Scopus - 56Web of Science - 53

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2008Clark MG, Rattigan S, Barrett EJ, Keske MAV, 'Last word on Point:Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise', Journal of Applied Physiology, 104, (3) pp. 900. ISSN 8750-7587 (2008) [Contribution to Refereed Journal]

DOI: 10.1152/japplphysiol.01318.2007 [eCite] [Details]

Citations: Scopus - 4Web of Science - 3

Co-authors: Clark MG; Rattigan S

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2008Clark MG, Rattigan S, Barrett EJ, Keske MAV, 'Point: Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise', Journal of Appliedy Physiology, 104, (3) pp. 889-891. ISSN 8750-7587 (2008) [Contribution to Refereed Journal]

DOI: 10.1152/japplphysiol.00779.2007 [eCite] [Details]

Citations: Scopus - 42Web of Science - 32

Co-authors: Clark MG; Rattigan S

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2007Clerk LH, Vincent MA, Barrett EJ, Lankford MF, Lindner JR, 'Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiotensin-converting enzyme inhibition ', American Journal of Physiology: Endocrinology and Metabolism, 293, (6) pp. E1804-E1809 . ISSN 0193-1849 (2007) [Refereed Article]

DOI: 10.1152/ajpendo.00498.2007 [eCite] [Details]

Citations: Scopus - 46Web of Science - 45

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2007Inyard AC, Clerk LH, Vincent MA, Barrett EJ, 'Contraction stimulates nitric oxide independent microvascular recruitment and increases muscle insulin uptake ', Diabetes, 56, (9) pp. 2194-2200 . ISSN 0012-1797 (2007) [Refereed Article]

DOI: 10.2337/db07-0020 [eCite] [Details]

Citations: Scopus - 48Web of Science - 45

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2006Clerk LH, Vincent MA, Jahn LA, Liu Z, Lindner JR, et al., 'Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle ', Diabetes, 55, (5) pp. 1436-1442. ISSN 0012-1797 (2006) [Refereed Article]

DOI: 10.2337/db05-1373 [eCite] [Details]

Citations: Scopus - 171Web of Science - 168

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2006Vincent MA, Clerk LH, Lindner JR, Price WJ, Jahn LA, et al., 'Mixed meal and light exercise each recruit muscle capillaries in healthy humans ', American Journal of Physiology: Endocrinology and Metabolism, 290, (6) pp. E1191-E1197. ISSN 0193-1849 (2006) [Refereed Article]

DOI: 10.1152/ajpendo.00497.2005 [eCite] [Details]

Citations: Scopus - 103Web of Science - 102

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2005Marro KI, Hyyti OM, Vincent MA, Kushmerick MJ, 'Validation and advantages of FAWSETS perfusion measurements in skeletal muscle ', N M R in Biomedicine: (Nuclear Magnetic Resonance), 18, (4) pp. 226-234. ISSN 0952-3480 (2005) [Refereed Article]

DOI: 10.1002/nbm.950 [eCite] [Details]

Citations: Scopus - 10Web of Science - 8

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2005Vincent MA, Clerk LH, Barrett E, Lankford MF, Lindner JR, 'Microvascular responses to insulin are abnormal in type 2 diabetes and are reversed by ACE-inhibitor therapy: assessment of microvascular recruitment by contrast ultrasound', American Society of Echocardiography. Journal, 18 pp. 500. ISSN 0894-7317 (2005) [Contribution to Refereed Journal]

[eCite] [Details]

2005Vincent MA, Clerk LH, Rattigan S, Clark MG, Barrett EJ, 'Active role for the vasculature in the delivery of insulin to skeletal muscle', Clinical and Experimental Pharmacology and Physiology, 32, (4) pp. 302-307. ISSN 0305-1870 (2005) [Refereed Article]

DOI: 10.1111/j.1440-1681.2005.04188.x [eCite] [Details]

Citations: Scopus - 49Web of Science - 46

Co-authors: Rattigan S

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2004Clerk LC, Vincent MA, Lindner J, Clark MG, Rattigan S, et al., 'The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake', Diabetes/Metabolism Reseach and Reviews, 20, (1) pp. 3-12. ISSN 1520-7552 (2004) [Refereed Article]

DOI: 10.1002/dmrr.414 [eCite] [Details]

Citations: Scopus - 73Web of Science - 68

Co-authors: Clark MG; Rattigan S

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2004Vincent MA, Clerk LH, Lindner JR, Klibanov AL, Clark MG, et al., 'Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo', Diabetes, 53, (6) pp. 1418-1423. ISSN 0012-1797 (2004) [Refereed Article]

DOI: 10.2337/diabetes.53.6.1418 [eCite] [Details]

Citations: Scopus - 226Web of Science - 218

Co-authors: Clark MG; Rattigan S

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2004Zhang L, Vincent MA, Richards SM, Clerk LH, Rattigan S, et al., 'Insulin sensitivity of muscle capillary recruitment in vivo', Diabetes, 53, (2) pp. 447-453. ISSN 0012-1797 (2004) [Refereed Article]

DOI: 10.2337/diabetes.53.2.447 [eCite] [Details]

Citations: Scopus - 118Web of Science - 109

Co-authors: Zhang L; Richards SM; Rattigan S; Clark MG

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2003Clark MG, Wallis MG, Barrett EJ, Vincent MA, Richards SM, et al., 'Blood flow and muscle metabolism: a focus on insulin action', American Journal of Physiology: Endocrinology and Metabolism, 284, (2) pp. E241-E258. ISSN 0193-1849 (2003) [Refereed Article]

DOI: 10.1152/ajpendo.00408.2002 [eCite] [Details]

Citations: Web of Science - 179

Co-authors: Clark MG; Richards SM; Rattigan S

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2003Vincent MA, Barrett EJ, Lindner JR, Clark MG, Rattigan S, 'Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin', American Journal of Physiology: Endocrinology and Metabolism, 285, (1 48-1) pp. E123-E129. ISSN 0193-1849 (2003) [Refereed Article]

DOI: 10.1152/ajpendo.00021.2003 [eCite] [Details]

Citations: Scopus - 195Web of Science - 183

Co-authors: Clark MG; Rattigan S

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2003Vincent MA, Montagnani M, Quon MJ, 'Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium', Current Diabetes Reports, 3, (4) pp. 279-288. ISSN 1534-4827 (2003) [Refereed Article]

DOI: 10.1007/s11892-003-0018-9 [eCite] [Details]

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2001Keske MAV, Rattigan S, Clark MG, 'Size-Dependent Effects of Microspheres on Vasoconstrictor-Mediated Change in Oxygen Uptake by Perfused Rat Hindlimb', Microvascular Research, 62, (3) pp. 306-314. ISSN 0026-2862 (2001) [Refereed Article]

DOI: 10.1006/mvre.2001.2344 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Rattigan S; Clark MG

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2001Keske MAV, Rattigan S, Clark MG, Bernard SL, Glenny RW, 'Spatial Distribution of Nutritive and Nonnutritive Vascular Routes in Perfused Rat Hindlimb Muscle Using Microspheres', Microvascular Research, 61, (1) pp. 111-121. ISSN 0026-2862 (2001) [Refereed Article]

DOI: 10.1006/mvre.2000.2278 [eCite] [Details]

Citations: Scopus - 4Web of Science - 3

Co-authors: Rattigan S; Clark MG

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2000Clark MG, Rattigan S, Clerk LH, Keske MAV, Clark AD, et al., 'Nutritive and non-nutritive blood flow: rest and exercise', Acta Physiologica Scandinavica, 168, (4) pp. 519-530. ISSN 0001-6772 (2000) [Refereed Article]

DOI: 10.1046/j.1365-201X.2000.00704.x [eCite] [Details]

Citations: Scopus - 55Web of Science - 50

Co-authors: Clark MG; Rattigan S; Clark AD; Newman JMB

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2000Griffiths CD, Keske MAV, Szallasi A, Colquhoun EQ, Geraghty DP, 'Functional and desensitizing effects of the novel synthetic vanilloid-like agent 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) in the perfused rat hindlimb', British Journal of Pharmacology, 131, (7) pp. 1408-1412. ISSN 0007-1188 (2000) [Refereed Article]

DOI: 10.1038/sj.bjp.0703702 [eCite] [Details]

Citations: Scopus - 2Web of Science - 1

Co-authors: Griffiths CD; Colquhoun EQ; Geraghty DP

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1999Youd JM, Newman JMB, Clark MG, Appleby GJ, Rattigan S, et al., 'Increased metabolism of infused 1-methylxanthine by working muscle', Acta Physiologica Scandinavica, 166, (4) pp. 301-308. ISSN 0001-6772 (1999) [Refereed Article]

DOI: 10.1046/j.1365-201x.1999.00572.x [eCite] [Details]

Citations: Scopus - 13Web of Science - 16

Co-authors: Newman JMB; Clark MG; Appleby GJ; Rattigan S

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1998Keske MAV, Rattigan S, Clark MG, 'Microsphere infusion reverses vasoconstrictor-mediated changes in hindlimb oxygen uptake and energy status', Acta Physiologica Scandinavica, 164, (1) pp. 61-70. ISSN 0001-6772 (1998) [Refereed Article]

DOI: 10.1046/j.1365-201X.1998.00408.x [eCite] [Details]

Citations: Scopus - 9Web of Science - 8

Co-authors: Rattigan S; Clark MG

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Chapter in Book

(4 outputs)
YearCitationAltmetrics
2013Premilovac D, Ng HLH, Richards SM, Bradley EA, Dwyer RM, et al., 'Role for the Microvasculature in Glucose Uptake in Skeletal Muscle', Glucose Uptake: Regulation, Signaling Pathways and Health Implications (Endocrinology Research and Clinical Developments), Nova Science Publishers, Johnson CC and Williams DB (ed), New York, pp. 109-139. ISBN 978-1-62618-670-5 (2013) [Research Book Chapter]

[eCite] [Details]

Co-authors: Premilovac D; Ng HLH; Richards SM; Bradley EA; Dwyer RM; Rattigan S

2000Clark MG, Keske MAV, 'Preparation and properties of isolated hepatocytes from sheep', The Hepatocyte Review, Kluwer Academic Publishers, Berry, Michael N., and Edwards, Anthony M. (ed), Dordrecht, NL, pp. 25-34. ISBN 0-7923-6177-6 (2000) [Research Book Chapter]

[eCite] [Details]

Co-authors: Clark MG

1998Clark MG, Rattigan S, Dora KA, Newman JMB, Keske MAV, 'Interaction between blood flow, metabolism and exercise', Biochemistry of Exercise X, Human Kinetics, M Hargreaves & M Thompson (ed), Champaign, pp. 35-46. ISBN 0-88011-758-3 (1998) [Research Book Chapter]

[eCite] [Details]

Co-authors: Clark MG; Rattigan S; Dora KA; Newman JMB

1997Clark MG, Rattigan S, Dora KA, Newman JMB, Steen JT, et al., 'Vascular and metabolic regulation of muscle', Physiology, Stress and Malnutrition, Lippincott-Raven, Kinney, JM & Tucker, HN (ed), Philadelphia, pp. 325-346. ISBN 0-397-58763-5 (1997) [Research Book Chapter]

[eCite] [Details]

Co-authors: Clark MG; Rattigan S; Dora KA; Newman JMB; Steen JT; Miller KAL

Conference Publication

(8 outputs)
YearCitationAltmetrics
2016Hu Donghua, Russell RD, Sharman JE, Rattigan S, Jacobson GA, et al., 'Effect of blueberry tea on improving metabolic and vascular function in people with and without type 2 diabetes - A Pilot Study', Australian Diabetes Society and Australian Diabetes Educators Association Annual Scientific Meeting 2016, 24-26 August, 2016, Gold Coast, Australia (2016) [Conference Extract]

[eCite] [Details]

Co-authors: Russell RD; Sharman JE; Rattigan S; Jacobson GA; Al-Aubaidy HAM; Richards SM

2014Pirie AD, Ahuja KDK, Jacobson GA, Geraghty DP, Narkowicz CK, et al., 'Glucose tolerance is improved by supplementation with carpobrotus rossii flavanoids in insulin resistant mice', Thirty-Eighth Annual Scientific Meeting of The Nutrition Society of Australia, 26 - 28 November, 2014, Hobart, Tasmania (2014) [Conference Extract]

[eCite] [Details]

Co-authors: Pirie AD; Ahuja KDK; Jacobson GA; Geraghty DP; Narkowicz CK

2011Newman JMB, Dwyer RM, Keske MAV, Richards SM, Rattigan S, 'Flow motion in skeletal muscle is associated with increased nutritive flow and insulin action', Proceedings of the 71st Scientific Sessions of the American Diabetes Association, 24-28 June, San Diego, California, pp. 1740-P. (2011) [Conference Extract]

[eCite] [Details]

Co-authors: Newman JMB; Dwyer RM; Richards SM; Rattigan S

2011Rattigan S, Newman JMB, Dwyer RM, Richards S, Keske MAV, 'Flow motion in skeletal muscle microvasculature is associated with increased nutritive flow', Australia and New Zealand Microcirculation Society Conference, 30 Nov - 3 Dec, Western Australia (2011) [Conference Extract]

[eCite] [Details]

Co-authors: Rattigan S; Newman JMB; Dwyer RM

2001Keske MAV, Rattigan S, Clark MG, Barrett EJ, 'Inhibition of nitric oxide synthase prevents insulin-stimulated capillary recruitment and glucose uptake in skeletal muscle in vivo', Diabetes, vol 50, Supplement 2, June 22-26, 2001, Philadelphia, pp. A334. ISSN 0012-1797 (2001) [Conference Extract]

[eCite] [Details]

Co-authors: Rattigan S; Clark MG

1997Newman JMB, Clark MG, Rattigan S, Appleby GJ, Keske MAV, et al., 'Effect of Muscle Contraction on Metabolism of 1-Methylxanthine and L-Arginine in the Constant-Flow Perfused Rat Hindlimb', 10th International Conference on the Biochemistry of Exercise, Sydney, pp. 76. (1997) [Conference Extract]

[eCite] [Details]

Co-authors: Newman JMB; Clark MG; Rattigan S; Appleby GJ

1997Youd JM, Rattigan S, Keske MAV, Clark MG, 'Sciatic Nerve Severance Produces Haemodynamic Changes and Insulin Resistance in Muscle', Diabetologia, Helsinki, pp. A257. (1997) [Conference Extract]

[eCite] [Details]

Co-authors: Rattigan S; Clark MG

1996Steen JT, Keske MAV, Clark MG, 'Resting muscle thermogenesis: novel mechanisms', Tenth International Hibernation Symposium, Cradle Mountain, Tasmania, pp. 305-310. (1996) [Non Refereed Conference Paper]

[eCite] [Details]

Co-authors: Steen JT; Clark MG

Thesis

(1 outputs)
YearCitationAltmetrics
2000Keske MAV, 'Vascular effects of vasoconstrictors on muscle metabolism' (2000) [PhD]

[eCite] [Details]

Grants & Funding

Since 2008 Dr Keske has obtained $3.3M in competitive grant funding to support her independent research program. $1M Quantum Leap Fellowship; $390k ARC Discovery Grant; $1.4M NHMRC Project Grants; $129k Heart Foundation Australia, $100k other local Tasmania Funds.

Funding Summary

Number of grants

14

Total funding

$3,111,042

Projects

Mixed Meal Challenge A new diagnostic test for screening pre diabetes (2016)$24,225
Description
The oral glucose tolerance test (GTT) is the gold standard for assessing pre-diabetes and type 2 diabetes (T2D), and is used world-wide. However, our researchgroup has made an important discovery demonstrating the GTT causes acute microvascular insulin resistance in healthy people. These findings have asignificant clinical impact as it implies that the GTT does not have the sensitivity to identify people with vascular-derived insulin resistance which is one of theearliest events in the development of pre-diabetes. Therefore, people with vascular‐derived insulin resistance are not being identified or diagnosed. We have developed an alternative test (the mixed meal challenge; MMC) and hypothesise it will have greater capacity to screen for pre-diabetes.Aim 1: Determine whether the MMC can identify pre-diabetes in a population of people that would otherwise be considered healthy in response to a GTT.Aim 2: Determine whether the benefits of the MMC as a new diagnostic test is linked to microvascular insulin sensitivity in skeletal muscle.
Funding
Royal Hobart Hospital Research Foundation ($24,225)
Scheme
Grant-Establishment
Administered By
University of Tasmania
Research Team
Keske MAV; Greenaway TM; Rattigan S; Russell RD; Neilson S
Year
2016
Promoting regrowth of nerve fibres into the epidermis during diabetic neuropathy by LRP agonists (2015 - 2017)$413,731
Funding
National Health & Medical Research Council ($413,731)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Foa LC; Taylor BVM; West AK; Keske MAV
Period
2015 - 2017
Grant Reference
1088952
Microvascular dysfunction in adult offspring of type 2 diabetics (2014)$20,294
Description
Offspring from type 2 diabetics (T2D) are at much greater risk of developing diabetes than a person with no family history. The mechanism for this increase in risk is not known. This project will determine whether microvascular dysfunction in skeletal muscle and skin of first degree relatives with T2D occurs before development of insulin resistance. We will recruit people with and without family history of T2D. It will measure microvascular actions (using ultrasound) in these people before and after a mixed meal challenge. The outcomes of this study will determine whether monitoring microvasculature responses in muscle is an important 'early' strategy for assessing risk that might inform patient treatment to prevent or delay progression to insulin resistance or T2D.
Funding
Royal Hobart Hospital Research Foundation ($20,294)
Scheme
Grant-Clinical Research
Administered By
University of Tasmania
Research Team
Keske MAV; Rattigan S; Sharman JE; Russell R; Premilovac D
Year
2014
Cardiometabolic benefits of exercise training in type 2 diabetes independent of weight loss (2014)$50,735
Description
This project will recruit an overweight type 2 diabetes cohort, medically assessed for an exercise program. It aims to recruit some with family history of type 2 diabetes and some without. The cohort with exercise test before and after 6 weeks of the exercise program, with type 2 medications discontinued before test. The aim is to show that heart health will not be as good with family history of type 2 and that exercise will improve heart health but will be of more benefit to those with a family history than those without.
Funding
University of Tasmania ($50,735)
Scheme
vTAHSP Demonstration Projects
Administered By
University of Tasmania
Research Team
Keske MAV; Greenaway T; Marwick TH; Dwyer RM; Rattigan S; Sharman JE; Premilovac D
Year
2014
The physiological benefits of anthocyanins as a functional food (2013)$7,500
Description
The overall aim of this project is to investigate the impact and to contribute to the evidence base for anthocyanins as a functional food.
Funding
Fruit Growers Tasmania Inc ($7,500)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Walls JT; Geraghty DP; Keske MAV; Blackhall ML
Year
2013
Role of microvascular flowmotion in skeletal muscle glucose metabolism (2013 - 2015)$576,533
Description
Obesity and type 2 diabetes are nationally and globally reaching epidemic rates. This project investigates the regulation of blood flow within muscle and its impact on metabolism. Outcomes from the study may lead to diagnostic tools and treatments for cardiovascular disease associated with obesity, hypertension and type 2 diabetes.
Funding
National Health & Medical Research Council ($576,533)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Rattigan S; Keske MAV; Richards SM; Dwyer RM
Period
2013 - 2015
Grant Reference
1043474_HF
Neural regulation of skeletal muscle insulin sensitivity (2012)$9,825
Funding
The Select Foundation ($9,825)
Scheme
Grant-Small Grants Scheme
Administered By
University of Tasmania
Research Team
Rattigan S; Keske MAV; Dickson TC
Year
2012
Adipose tissue blood flow: the link between obesity and disease risk? (2012)$7,580
Funding
The Select Foundation ($7,580)
Scheme
Grant-Small Grants Scheme
Administered By
University of Tasmania
Research Team
Richards SM; Keske MAV
Year
2012
Actions of the polyphenol epigallocatechin 3-gallate on insulin sensitivity (2011 - 2013)$395,518
Funding
National Health & Medical Research Council ($395,518)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Keske MAV; Rattigan S; Quon M
Period
2011 - 2013
Grant Reference
1009962
Metabolic and vascular actions of EGCG on insulin sensitivity (2011 - 2013)$15,000
Funding
Diabetes Tasmania ($15,000)
Scheme
Scholarship
Administered By
University of Tasmania
Research Team
Keske MAV
Period
2011 - 2013
Microvascular Defects and Insulin Resistance (2011 - 2012)$127,490
Funding
National Heart Foundation ($127,490)
Scheme
Grant-In-Aid
Administered By
University of Tasmania
Research Team
Rattigan S; Keske MAV; Richards SM
Period
2011 - 2012
Quantum Leap Fellowship (2008 - 2012)$1,000,000
Funding
Menzies Research Institute Tasmania / University of Tasmania ($1,000,000)
Scheme
Fellowship
Administered By
Menzies Research Institute Tasmania
Research Team
Keske MAV
Period
2008 - 2012
NHMRC Standard Equipment Grant - 2008 (2008)$72,611
Funding
National Health & Medical Research Council ($72,611)
Scheme
Grant-Equipment
Administered By
University of Tasmania
Research Team
Keske MAV; Rattigan S; Richards SM
Year
2008
Grant Reference
580023
Blood Flow Routes in Muscle (2008 - 2010)$390,000
Funding
Australian Research Council ($390,000)
Scheme
Grant-Discovery Projects
Administered By
University of Tasmania
Research Team
Keske MAV; Rattigan S
Period
2008 - 2010
Grant Reference
DP0877385

Research Supervision

Since 2008 Dr Keske has supervised 2 post-doctoral fellows, 1 research assistant, 4 PhD and 11 Honours candidates (current supervision 1 post-doctoral fellow and 3 PhD candidates).

Current

2

Completed

4

Current

DegreeTitleCommenced
PhDInflammation is Not a Contributing Factor in the Development of Insulin Resistance in Diet Induced Obesity in Rats2013
PhDThe microvascular effects of novel flavonoid compounds on enhancing the action of anti-diabetic drugs2014

Completed

DegreeTitleCompleted
PhDCharacterisation of Flowmotion in Healthy Controls and Type 2 Diabetes
Candidate: Sarah Joan Blackwood
2017
PhDThe Pharmaceutical and Nutraceutical Potential of the Halophytic Plant Carpobrotus rossii
Candidate: Adam Douglas Pirie
2014
PhDEffect of the Green Tea Polyphenol, EGCG, on Insulin Sensitivity
Candidate: Huei Leng Helena Ng
2014
PhDMicrovascular Dysfunction and the Development of Muscle Insulin Resistance
Candidate: Dino Premilovac
2012