Profiles

Tracey Dickson

UTAS Home Assoc Prof Tracey Dickson
Tracey Dickson

Tracey Dickson

Deputy Director
Menzies Institute for Medical Research

Hobart CBD Campuses

+61 3 6226 4829 (phone)

Tracey.Dickson@utas.edu.au

If brain cells become damaged through a trauma or they degenerate and die, as they do in age-related brain diseases, the brain stops functioning as it should. Dementia, Parkinson's disease and motor neurone disease are the types of conditions that result. What causes certain brain cells to die? Can we slow or stop that degenerative cascade? If not, can we repurpose other uninjured cells in the brain to take on the job previously done by the cells that are damaged?

Solving the riddle of neurodegenerative disease

Associate Professor Tracey Dickson is a neuroscientist specialising in neurodegenerative diseases and brain trauma. She is collaborating with researchers all over the world to find answers to these questions.

'This is an enormous challenge. Neurodegenerative diseases are some of the worst diseases on the planet, and for many of them we don't have treatments or a cure. Finding a cure is going to take the expertise of many national and international scientists.'

'I'm trying to find out what mechanisms cause certain brain cells to degenerate, stop functioning and ultimately die. We know that there are similarities happening at the cellular level common to a range of neurodegenerative diseases. Where the cell death occurs in the brain is what determines the symptoms specific to each disease,' said Associate Professor Dickson.

'If we could find those initial mechanisms that initiate brain cell degeneration, then we could potentially solve the riddle of a range of devastating diseases.'

'Ultimately, we want to find out how to stop or slow the progression of brain cell degeneration. But we are also trying to find other ways to regain the functions lost.'

'We want to know if we can increase the capacity of the healthy cells within the brain to pick up the jobs previously done by the damaged cells, perhaps by modifying or changing them in some way. Brain cells also have thousands of connections. There may be a way to rewire these.'

Finding a way to get the brain to respond in a positive way and regain lost function would also help those affected by a head injury.

Associate Professor Dickson said that the Tasmanian community is both her inspiration and a source of innovation.

'We give public talks often. People regularly tell me stories of family members with neurodegenerative disease and say: Thank you for working so hard on this terrible disease; Is there a trial that I can be a part of to help you?'

'Community groups, like the Masonic Medical Research Foundation, Parkinson's Tasmania and the Cape Hope Tasmania Foundation, fund innovative research projects that are often in their infancy. Often it is by pursuing the fringe ideas that the best discoveries are made.'

'They don't expect a cure tomorrow. They are proud of the work that we are doing here and want to see internationally important research done that will contribute a piece of the puzzle, which might one day lead to a cure.'

'If we can each uncover one piece of the puzzle, then we will get to a cure much faster.'

A/Prof Dickson has a PhD in Neuroscience and is the Deputy Director and Leader of the Neurodegenerative disease Trauma theme at the Menzies Institute for Medical Research. She has an excellent track record, national and international reputation, and over 15 years experience in the fields of neurodegenerative disease research, particularly MND. She has extensive expertise in performing and analysing multiple label immunohistochemistry in human and transgenic tissue to provide insight into disease mechanism and has advanced primary culture and microscopy skills. She has a track record of successfully leading large scale collaborative research projects.

Career summary

Research Themes

A/Prof Dickson's research interests align with one of the University's key research themes of Better Health. She is a neuroscientist with a national and international reputation in determining the pathological basis underlying Motor Neuron Disease, dementia, Parkinson's disease and the neuronal response to trauma. Dickson has established her career by defining cellular mechanisms of neurodegenerative disease through the development of targeted in vitro primary culture models and the pathological analysis of human and transgenic tissue. She gave an invited oral presentation at the International Symposium of ALS/MND research in Milan (2013), at the National MND meeting (2013, 2014) and at the Asia Pacific FTD/MND. Her work on MND and axonal pathology has also been the subject of invited symposium presentations for the Australian Neuroscience Society (2011).

Memberships

Professional practice

A/Prof Dickson Chairs the University of Tasmania Animal Ethics Committee, is a member of the University of Tasmania Research Integrity and Ethics Committee and chair of the Menzies Equity and Diversity Committee. A/Prof Dickson is a member of the Tasmanian Government Animal Welfare Advisory Committee.

Other

A/Prof Dickson currently serves on the editorial board of the international journal Neurotoxicity Research (Springer) and has served as a member of an NHMRC grant review panel three times. She is member of Australian Neuroscience Society (ANS) Council and the Chair of the Local Organising Committee for the ANS annual meeting (2016, Hobart) and has been a member of the LOC for the National Neurotrauma meeting (2008-2013). She reviews annual project grants and/or fellowship applications for NHMRC, ARC, Alzheimer's Association (UK), Medical Research Council (UK) and Dutch NOW.

Teaching

Teaching expertise

A/Prof Dickson is currently supervising full-time PhD students and honours students. She has supervised PhD students to completion – many of which have received nationally competitive scholarships, post-doctoral fellowships and awards – and honours students (10 received first class).

Research Invitations

A/Prof Dickson is an invited member of the National Research Committee for the Motor Neuron Disease Australia. She was also an invited participant in the National Academy of Science High Fliers Think Tank (2013) 'Inspiring Smarter Brain Research in Australia'.

View more on AssocProf Tracey Dickson in WARP

Fields of Research

  • Central Nervous System (110903)
  • Neurology and Neuromuscular Diseases (110904)
  • Cellular Nervous System (110902)
  • Neurosciences (110999)
  • Animal Physiology - Biophysics (060601)
  • Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) (060106)
  • Peripheral Nervous System (110905)
  • Biological Sciences (069999)
  • Biochemistry and Cell Biology (060199)
  • Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) (170101)
  • Cardiology (incl. Cardiovascular Diseases) (110201)
  • Autonomic Nervous System (110901)
  • Medical Bacteriology (110801)
  • Pathology (110316)
  • Cell Metabolism (060104)
  • Medical and Health Sciences (119999)
  • Instrumental Methods (excl. Immunological and Bioassay Methods) (030105)
  • Analytical Chemistry (030199)
  • Epigenetics (incl. Genome Methylation and Epigenomics) (060404)
  • Chemical Sciences (039999)
  • Protein Trafficking (060108)
  • Epidemiology (111706)
  • Cell Development, Proliferation and Death (060103)
  • Bioethics (human and animal) (220101)
  • Endocrinology (110306)
  • Microtechnology (091009)
  • Cardiorespiratory Medicine and Haematology (110299)
  • Physiology (060699)
  • Clinical Nursing: Secondary (Acute Care) (111003)
  • Separation Science (030108)
  • Metabolic Medicine (110107)
  • Cell Physiology (111601)
  • Biomedical Engineering (090399)
  • Clinical Sciences (110399)
  • Cell Neurochemistry (060105)
  • Sensory Systems (110906)
  • Medical Biotechnology (100499)
  • Biomechanical Engineering (090302)

Research Objectives

  • Nervous System and Disorders (920111)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Expanding Knowledge in the Biological Sciences (970106)
  • Diabetes (920104)
  • Health (929999)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Expanding Knowledge in the Chemical Sciences (970103)
  • Cardiovascular System and Diseases (920103)
  • Scientific Instruments (861503)
  • Skeletal System and Disorders (incl. Arthritis) (920116)
  • Disease Distribution and Transmission (incl. Surveillance and Response) (920404)
  • Immune System and Allergy (920108)
  • Blood Disorders (920101)
  • Health Related to Ageing (920502)
  • Fabricated Metal Products (861299)
  • Infectious Diseases (920109)
  • Expanding Knowledge in Technology (970110)
  • Child Health (920501)
  • Aboriginal and Torres Strait Islander Health - Health System Performance (incl. Effectiveness of Interventions) (920303)
  • Clinical Health (Organs, Diseases and Abnormal Conditions) (920199)
  • Public Health (excl. Specific Population Health) (920499)
  • Medical Instruments (861502)

Publications

Total publications

129

Highlighted publications

(8 outputs)
YearTypeCitationAltmetrics
2017Journal ArticleClark RM, Blizzard CA, Young KM, King AE, Dickson TC, 'Calretinin and Neuropeptide Y interneurons are differentially altered in the motor cortex of the SOD1G93A mouse model of ALS', Scientific Reports, 7 Article 44461. ISSN 2045-2322 (2017) [Refereed Article]

DOI: 10.1038/srep44461 [eCite] [Details]

Co-authors: Clark RM; Blizzard CA; Young KM; King AE

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2016Journal ArticleHandley EE, Pitman KA, Dawkins E, Young KM, Clark RM, et al., 'Synapse dysfunction of layer V pyramidal neurons precedes neurodegeneration in a mouse model of TDP-43 proteinopathies', Cerebral Cortex, 27, (7) pp. 3630-3647. ISSN 1047-3211 (2016) [Refereed Article]

DOI: 10.1093/cercor/bhw185 [eCite] [Details]

Citations: Web of Science - 4

Co-authors: Pitman KA; Dawkins E; Young KM; Clark RM; Blizzard CA

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2015Journal ArticleBlizzard CA, Southam KA, Dawkins E, Lewis KE, King AE, et al., 'Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis - vulnerability of lower motor neurons to proximal excitotoxicity', Disease Models & Mechanisms, 8, (3) pp. 215-224. ISSN 1754-8403 (2015) [Refereed Article]

DOI: 10.1242/dmm.018606 [eCite] [Details]

Citations: Scopus - 8Web of Science - 7

Co-authors: Blizzard CA; Southam KA; Dawkins E; Lewis KE; King AE; Clark JA

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2013Journal ArticleBlizzard CA, King AE, Vickers J, Dickson T, 'Cortical murine neurons lacking the neurofilament light chain protein have an attenuated response to injury in vitro', Journal of Neurotrauma, 30, (22) pp. 1908-1918. ISSN 0897-7151 (2013) [Refereed Article]

DOI: 10.1089/neu.2013.2850 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Blizzard CA; King AE; Vickers J

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2010Journal ArticleBlizzard CA, Chuckowree JA, King AE, Hosie KA, McCormack GH, et al., 'Focal Damage to the Adult Rat Neocortex Induces Wound Healing Accompanied by Axonal Sprouting and Dendritic Structural Plasticity ', Cerebral Cortex, 21, (2) pp. 281-291. ISSN 1047-3211 (2010) [Refereed Article]

DOI: 10.1093/cercor/bhq091 [eCite] [Details]

Citations: Scopus - 25Web of Science - 25

Co-authors: Blizzard CA; Chuckowree JA; King AE; Hosie KA; McCormack GH; Chapman JA; Vickers JC

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2010Journal ArticleMitew S, Kirkcaldie MTK, Halliday G, Shepherd CE, Vickers JC, et al., 'Focal demyelination in Alzheimer's disease and transgenic mouse models', Acta Neuropathologica, 119, (5) pp. 567-577. ISSN 0001-6322 (2010) [Refereed Article]

DOI: 10.1007/s00401-010-0657-2 [eCite] [Details]

Citations: Scopus - 53Web of Science - 44

Co-authors: Mitew S; Kirkcaldie MTK; Vickers JC

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2006Journal ArticleKing AE, Chung RS, Vickers JC, Dickson TC, 'Localisation of glutamate receptors in developing cortical neurons in culture and relationship to susceptibility to excitotoxicity', Journal of Comparative Neurology, 498, (2) pp. 277-294. ISSN 0021-9967 (2006) [Refereed Article]

DOI: 10.1002/cne.21053 [eCite] [Details]

Citations: Scopus - 39Web of Science - 38

Co-authors: King AE; Chung RS; Vickers JC

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2002Journal ArticleDickson TC, Mintz CD, Benson DL, Salton SRJ, 'Functional binding interaction identified between the axonal CAM L1 members of the ERM family', Journal of Cell Biology, 157, (7) pp. 1105-1112. ISSN 0021-9525 (2002) [Refereed Article]

DOI: 10.1083/jcb.200111076 [eCite] [Details]

Citations: Scopus - 109Web of Science - 109

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Journal Article

(69 outputs)
YearCitationAltmetrics
2017Brizuela M, Blizzard CA, Chuckowree JA, Pitman KA, Young KM, et al., 'Mild traumatic brain injury leads to decreased inhibition and a differential response of calretinin positive interneurons in the Injured cortex', Journal of Neurotrauma, 34, (17) pp. 2504-2517. ISSN 0897-7151 (2017) [Refereed Article]

DOI: 10.1089/neu.2017.4977 [eCite] [Details]

Co-authors: Brizuela M; Blizzard CA; Chuckowree JA; Pitman KA; Young KM

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2017Clark RM, Blizzard CA, Young KM, King AE, Dickson TC, 'Calretinin and Neuropeptide Y interneurons are differentially altered in the motor cortex of the SOD1G93A mouse model of ALS', Scientific Reports, 7 Article 44461. ISSN 2045-2322 (2017) [Refereed Article]

DOI: 10.1038/srep44461 [eCite] [Details]

Co-authors: Clark RM; Blizzard CA; Young KM; King AE

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2017Yap YC, King AE, Guijt RM, Jiang T, Blizzard CA, et al., 'Mild and repetitive very mild axonal stretch injury triggers cystoskeletal mislocalization and growth cone collapse', PLoS One, 12, (5) Article e0176997. ISSN 1932-6203 (2017) [Refereed Article]

DOI: 10.1371/journal.pone.0176997 [eCite] [Details]

Co-authors: Yap YC; King AE; Guijt RM; Blizzard CA; Breadmore MC

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2016Clark JA, Southam KA, Blizzard CA, King AE, Dickson TC, 'Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis', Journal of Chemical Neuroanatomy, 76, (Pt A) pp. 35-47. ISSN 0891-0618 (2016) [Refereed Article]

DOI: 10.1016/j.jchemneu.2016.03.003 [eCite] [Details]

Citations: Scopus - 7Web of Science - 6

Co-authors: Clark JA; Southam KA; Blizzard CA; King AE

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2016Clark JA, Yeaman EJ, Blizzard CA, Chuckowree JA, Dickson TC, 'A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During Disease', Frontiers in Cellular Neuroscience, 10 Article 204. ISSN 1662-5102 (2016) [Refereed Article]

DOI: 10.3389/fncel.2016.00204 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Clark JA; Yeaman EJ; Blizzard CA; Chuckowree JA

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2016Wang S, Bolos M, Clark R, Cullen CL, Southam KA, et al., 'Amyloid β precursor protein regulates neuron survival and maturation in the adult mouse brain', Molecular and Cellular Neurosciences, 77 pp. 21-33. ISSN 1044-7431 (2016) [Refereed Article]

DOI: 10.1016/j.mcn.2016.09.002 [eCite] [Details]

Citations: Scopus - 4Web of Science - 3

Co-authors: Wang S; Bolos M; Clark R; Cullen CL; Southam KA; Foa L; Young KM

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2016Blizzard CA, Lee KM, Dickson TC, 'Inducing chronic excitotoxicity in the mouse spinal cord to investigate lower motor neuron degeneration', Frontiers in Neuroscience, 10 Article 76. ISSN 1662-453X (2016) [Refereed Article]

DOI: 10.3389/fnins.2016.00076 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Blizzard CA; Lee KM

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2016Handley EE, Pitman KA, Dawkins E, Young KM, Clark RM, et al., 'Synapse dysfunction of layer V pyramidal neurons precedes neurodegeneration in a mouse model of TDP-43 proteinopathies', Cerebral Cortex, 27, (7) pp. 3630-3647. ISSN 1047-3211 (2016) [Refereed Article]

DOI: 10.1093/cercor/bhw185 [eCite] [Details]

Citations: Web of Science - 4

Co-authors: Pitman KA; Dawkins E; Young KM; Clark RM; Blizzard CA

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2015Brizuela M, Blizzard CA, Chuckowree JA, Dawkins E, Gasperini RJ, et al., 'The microtubule-stabilizing drug Epothilone D increases axonal sprouting following transection injury in vitro', Molecular and Cellular Neurosciences, 66, (Part B) pp. 129-140. ISSN 1044-7431 (2015) [Refereed Article]

DOI: 10.1016/j.mcn.2015.02.006 [eCite] [Details]

Citations: Scopus - 11Web of Science - 10

Co-authors: Brizuela M; Blizzard CA; Chuckowree JA; Dawkins E; Gasperini RJ; Young KM

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2015Radford R, Rcom-H'cheo-Gauthier A, Wong MB, Eaton ED, Quilty M, et al., 'The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions', Molecular and Cellular Neuroscience, 65 pp. 68-81. ISSN 1044-7431 (2015) [Refereed Article]

DOI: 10.1016/j.mcn.2015.02.015 [eCite] [Details]

Citations: Scopus - 10Web of Science - 10

Co-authors: Eaton ED; Quilty M; Blizzard C; Vickers JC; West AK

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2015Blizzard CA, Southam KA, Dawkins E, Lewis KE, King AE, et al., 'Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis - vulnerability of lower motor neurons to proximal excitotoxicity', Disease Models & Mechanisms, 8, (3) pp. 215-224. ISSN 1754-8403 (2015) [Refereed Article]

DOI: 10.1242/dmm.018606 [eCite] [Details]

Citations: Scopus - 8Web of Science - 7

Co-authors: Blizzard CA; Southam KA; Dawkins E; Lewis KE; King AE; Clark JA

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2015Clark R, Blizzard C, Dickson T, 'Inhibitory dysfunction in amyotrophic lateral sclerosis: future therapeutic opportunities', Neurodegenerative Disease Management, 5, (6) pp. 511-525. ISSN 1758-2024 (2015) [Refereed Article]

DOI: 10.2217/nmt.15.49 [eCite] [Details]

Citations: Scopus - 1Web of Science - 3

Co-authors: Clark R; Blizzard C

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2014Musgrove RE, Horne H, Wilson R, King AE, Edwards LM, et al., 'The metabolomics of alpha-synuclein (SNCA) gene deletion and mutation in mouse brain', Metabolomics, 10, (1) pp. 114-122. ISSN 1573-3882 (2014) [Refereed Article]

DOI: 10.1007/s11306-013-0561-6 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Musgrove RE; Horne H; Wilson R; King AE; Edwards LM

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2014Yap YC, Dickson TC, King AE, Breadmore MC, Guijt RM, 'Microfluidic culture platform for studying neuronal response to mild to very mild axonal stretch injury', Biomicrofluidics, 8, (4) Article 044110. ISSN 1932-1058 (2014) [Refereed Article]

DOI: 10.1063/1.4891098 [eCite] [Details]

Citations: Web of Science - 3

Co-authors: Yap YC; King AE; Breadmore MC; Guijt RM

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2013Blizzard CA, King AE, Vickers J, Dickson T, 'Cortical murine neurons lacking the neurofilament light chain protein have an attenuated response to injury in vitro', Journal of Neurotrauma, 30, (22) pp. 1908-1918. ISSN 0897-7151 (2013) [Refereed Article]

DOI: 10.1089/neu.2013.2850 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Blizzard CA; King AE; Vickers J

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2013Mitew S, Kirkcaldie MTK, Dickson TC, Vickers JC, 'Altered synapses and gliotransmission in Alzheimer's disease and AD model mice', Neurobiology of Aging, 34, (10) pp. 2341-2351. ISSN 0197-4580 (2013) [Refereed Article]

DOI: 10.1016/j.neurobiolaging.2013.04.010 [eCite] [Details]

Citations: Scopus - 49Web of Science - 46

Co-authors: Mitew S; Kirkcaldie MTK; Vickers JC

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2013Mitew S, Kirkcaldie MTK, Dickson TC, Vickers JC, 'Neurites containing the neurofilament-triplet proteins are selectively vulnerable to cytoskeletal pathology in Alzheimer's disease and transgenic mouse models', Frontiers in Neuroanatomy, 7 Article 30. ISSN 1662-5129 (2013) [Refereed Article]

DOI: 10.3389/fnana.2013.00030 [eCite] [Details]

Citations: Scopus - 7Web of Science - 8

Co-authors: Mitew S; Kirkcaldie MTK; Vickers JC

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2013Bibari O, Lee S, Dickson TC, Mitew S, Vickers JC, et al., 'Denervation of the olfactory bulb leads to decreased Aβ plaque load in a transgenic mouse model of Alzheimer's disease', Current Alzheimer Research, 10, (7) pp. 688-696. ISSN 1567-2050 (2013) [Refereed Article]

DOI: 10.2174/15672050113109990147 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Bibari O; Mitew S; Vickers JC; Chuah MI

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2013Southam KA, King AE, Blizzard CA, McCormack GH, Dickson TC, 'Microfluidic primary culture model of the lower motor neuron-neuromuscular junction circuit', Journal of Neuroscience Methods, 218, (2) pp. 164-169. ISSN 0165-0270 (2013) [Refereed Article]

DOI: 10.1016/j.jneumeth.2013.06.002 [eCite] [Details]

Citations: Scopus - 26Web of Science - 20

Co-authors: Southam KA; King AE; Blizzard CA; McCormack GH

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2013Yap YC, Guijt RM, Dickson TC, King AE, Breadmore MC, 'Stainless steel pinholes for fast fabrication of high-performance microchip electrophoresis devices by CO2 laser ablation', Analytical Chemistry, 85, (21) pp. 10051-10056. ISSN 0003-2700 (2013) [Refereed Article]

DOI: 10.1021/ac402631g [eCite] [Details]

Citations: Scopus - 7Web of Science - 7

Co-authors: Yap YC; Guijt RM; King AE; Breadmore MC

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2013Musgrove REJ, King AE, Dickson TC, 'α-Synuclein protects neurons from apoptosis downstream of free-radical production through modulation of the MAPK signalling pathway', Neurotoxicity Research, 23, (4) pp. 358-369. ISSN 1476-3524 (2013) [Refereed Article]

DOI: 10.1007/s12640-012-9352-5 [eCite] [Details]

Citations: Scopus - 12Web of Science - 12

Co-authors: Musgrove REJ; King AE

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2012Hosie KA, King AE, Blizzard CA, Vickers JC, Dickson TC, 'Chronic excitotoxin-induced axon degeneration in a compartmented neuronal culture model', ASN Neuro, 4, (1) Article e00076. ISSN 1759-0914 (2012) [Refereed Article]

DOI: 10.1042/AN20110031 [eCite] [Details]

Citations: Scopus - 21Web of Science - 13

Co-authors: Hosie KA; King AE; Blizzard CA; Vickers JC

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2012Liu Yao, Staal JA, Canty AJ, Kirkcaldie MTK, King AE, et al., 'Cytoskeletal changes during development and aging in the cortex of neurofilament light protein knockout mice', The Journal of Comparative Neurology, 521, (8) pp. 1817-1827. ISSN 0021-9967 (2012) [Refereed Article]

DOI: 10.1002/cne.23261 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Liu Yao; Staal JA; Canty AJ; Kirkcaldie MTK; King AE; Bibari O; Mitew ST; Vickers JC

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2012King AE, Blizzard CA, Southam KA, Vickers JC, Dickson TC, 'Degeneration of axons in spinal white matter in G93A mSOD1 mouse characterized by NFL and alpha internexin immunoreactivity', Brain Research, 1465 pp. 90-100. ISSN 0006-8993 (2012) [Refereed Article]

DOI: 10.1016/j.brainres.2012.05.018 [eCite] [Details]

Citations: Scopus - 8Web of Science - 5

Co-authors: King AE; Blizzard CA; Southam KA; Vickers JC

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2011Pountney DL, Dickson TC, Power JHT, Vickers JC, West AK, et al., 'Association of Metallothionein-III with Oligodendroglial Cytoplasmic Inclusions in Multiple System Atrophy', Neurotoxicity Research: An International Journal on Processes and Mechanisms in Neurodegeneration, Apoptosis, Neuroprotection and Regeneration, 19, (1) pp. 115-122. ISSN 1029-8428 (2011) [Refereed Article]

DOI: 10.1007/s12640-009-9146-6 [eCite] [Details]

Citations: Scopus - 10Web of Science - 6

Co-authors: Vickers JC; West AK

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2011King AE, Dickson TC, Blizzard CA, Woodhouse A, Foster SS, et al., 'Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology', Neurobiology of Aging: Experimental and Clinical Research, 32, (3) pp. 459-469. ISSN 0197-4580 (2011) [Refereed Article]

DOI: 10.1016/j.neurobiolaging.2009.04.004 [eCite] [Details]

Citations: Scopus - 19Web of Science - 18

Co-authors: King AE; Blizzard CA; Woodhouse A; Foster SS; Chung RS; Vickers JC

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2011Staal JA, Alexander SR, Liu Y, Dickson TC, Vickers JC, 'Characterization of Cortical Neuronal and Glial Alterations during Culture of Organotypic Whole Brain Slices from Neonatal and Mature Mice', PLoS One , 6, (7) Article e22040. ISSN 1932-6203 (2011) [Refereed Article]

DOI: 10.1371/journal.pone.0022040 [eCite] [Details]

Citations: Scopus - 19Web of Science - 16

Co-authors: Staal JA; Alexander SR; Liu Y; Vickers JC

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2010Blizzard CA, Chuckowree JA, King AE, Hosie KA, McCormack GH, et al., 'Focal Damage to the Adult Rat Neocortex Induces Wound Healing Accompanied by Axonal Sprouting and Dendritic Structural Plasticity ', Cerebral Cortex, 21, (2) pp. 281-291. ISSN 1047-3211 (2010) [Refereed Article]

DOI: 10.1093/cercor/bhq091 [eCite] [Details]

Citations: Scopus - 25Web of Science - 25

Co-authors: Blizzard CA; Chuckowree JA; King AE; Hosie KA; McCormack GH; Chapman JA; Vickers JC

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2010Mitew S, Kirkcaldie MTK, Halliday G, Shepherd CE, Vickers JC, et al., 'Focal demyelination in Alzheimer's disease and transgenic mouse models', Acta Neuropathologica, 119, (5) pp. 567-577. ISSN 0001-6322 (2010) [Refereed Article]

DOI: 10.1007/s00401-010-0657-2 [eCite] [Details]

Citations: Scopus - 53Web of Science - 44

Co-authors: Mitew S; Kirkcaldie MTK; Vickers JC

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2010Musgrove REJ, King AE, Dickson TC, 'Neuroprotective upregulation of endogenous alpha-synuclein precedes ubiquitination in cultured dopaminergic neurons ', Neurotoxicity Research , 19, (4) pp. 592-602. ISSN 1029-8428 (2010) [Refereed Article]

DOI: 10.1007/s12640-010-9207-x [eCite] [Details]

Citations: Scopus - 10Web of Science - 9

Co-authors: Musgrove REJ; King AE

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2010Staal JA, Dickson TC, Gasperini R, Liu Y, Foa L, et al., 'Initial calcium release from intracellular stores followed by calcium dysregulation is linked to secondary axotomy following transient axonal stretch injury', Journal of Neurochemistry, 112, (5) pp. 1147-1155. ISSN 0022-3042 (2010) [Refereed Article]

DOI: 10.1111/j.1471-4159.2009.06531.x [eCite] [Details]

Citations: Scopus - 51Web of Science - 45

Co-authors: Staal JA; Gasperini R; Liu Y; Foa L; Vickers JC

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2009Blizzard CA, King AE, Haas MA, O'Toole DA, Vickers JC, et al., 'Axonal shearing in mature cortical neurons induces attempted regeneration and the reestablishment of neurite polarity', Brain Research: International Multidisciplinary Journal Devoted to Fundamental Research in The Brain Sciences, 1300, (November) pp. 24-36. ISSN 0006-8993 (2009) [Refereed Article]

DOI: 10.1016/j.brainres.2009.08.059 [eCite] [Details]

Citations: Scopus - 1Web of Science - 2

Co-authors: Blizzard CA; King AE; Haas MA; O'Toole DA; Vickers JC

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2009Staal JA, Dickson TC, Chung RS, Vickers JC, 'Disruption of the Ubiquitin Proteasome System following Axonal Stretch Injury Accelerates Progression to Secondary Axotomy', Journal of Neurotrauma, 26, (5) pp. 781-788. ISSN 0897-7151 (2009) [Refereed Article]

DOI: 10.1089/neu.2008.0669 [eCite] [Details]

Citations: Scopus - 11Web of Science - 10

Co-authors: Staal JA; Chung RS; Vickers JC

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2009Vickers JC, King AE, Woodhouse A, Kirkcaldie MT, Staal JA, et al., 'Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system ', Brain Research Bulletin, 80, (4-5) pp. 217-223. ISSN 0361-9230 (2009) [Refereed Article]

DOI: 10.1016/j.brainresbull.2009.08.004 [eCite] [Details]

Citations: Scopus - 33Web of Science - 31

Co-authors: Vickers JC; King AE; Woodhouse A; Kirkcaldie MT; Staal JA; McCormack GH; Blizzard CA; Musgrove REJ; Mitew S; Liu Y; Chuckowree JA; Bibari O

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2009Woodhouse A, Shepherd CE, Sokolova A, Carroll VL, King AE, et al., 'Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease', Acta Neuropathologica, 117, (1) pp. 19-29. ISSN 0001-6322 (2009) [Refereed Article]

DOI: 10.1007/s00401-008-0458-z [eCite] [Details]

Citations: Scopus - 18Web of Science - 15

Co-authors: Woodhouse A; Sokolova A; King AE; Vickers JC

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2009Woodhouse A, Vickers JC, Adlard PA, Dickson TC, 'Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging', Neurobiology of Aging, 30, (6) pp. 864-874. ISSN 0197-4580 (2009) [Refereed Article]

DOI: 10.1016/j.neurobiolaging.2007.09.003 [eCite] [Details]

Citations: Scopus - 27Web of Science - 23

Co-authors: Woodhouse A; Vickers JC

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2008Mintz CD, Carcea I, McNickle DG, Dickson TC, Ge Y, et al., 'ERM Proteins Regulate Growth Cone Responses to Sema3A', The Journal of Comparative Neurology, 510, (4) pp. 351-366. ISSN 0021-9967 (2008) [Refereed Article]

DOI: 10.1002/cne.21799 [eCite] [Details]

Citations: Scopus - 26Web of Science - 26

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2007Blizzard CA, Haas MA, Vickers JC, Dickson TC, 'Cellular dynamics underlying regeneration of damaged axons differs from initial axon development', European Journal of Neuroscience, 26, (5) pp. 1100-1108. ISSN 0953-816X (2007) [Refereed Article]

DOI: 10.1111/j.1460-9568.2007.05750.x [eCite] [Details]

Citations: Scopus - 22Web of Science - 20

Co-authors: Blizzard CA; Haas MA; Vickers JC

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2007Haas MA, Chuckowree JA, Chung RS, Vickers JC, Dickson TC, 'Identification and characterization of a population of motile neurons in long-term cortical culture', Cell Motility and the Cytoskeleton, 64, (4) pp. 274-287. ISSN 0886-1544 (2007) [Refereed Article]

DOI: 10.1002/cm.20182 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Haas MA; Chuckowree JA; Chung RS; Vickers JC

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2007Haas MA, Vickers JC, Dickson TC, 'Rho kinase activates ezrin-radixin-moesin (ERM) proteins and mediates their function in cortical neuron growth, morphology and motility in vitro', Journal of Neuroscience Research, 85, (1) pp. 34-46. ISSN 0360-4012 (2007) [Refereed Article]

DOI: 10.1002/jnr.21102 [eCite] [Details]

Citations: Scopus - 36Web of Science - 36

Co-authors: Haas MA; Vickers JC

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2007King AE, Dickson TC, Blizzard CA, Foster SS, Chung RS, et al., 'Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons', European Journal of Neuroscience, 26, (8) pp. 2151-2159. ISSN 0953-816X (2007) [Refereed Article]

DOI: 10.1111/j.1460-9568.2007.05845.x [eCite] [Details]

Citations: Scopus - 27Web of Science - 21

Co-authors: King AE; Blizzard CA; Foster SS; Chung RS; West AK; Chuah MI; Vickers JC

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2007Staal JA, Dickson TC, Chung RS, Vickers JC, 'Cyclosporin - a treatment attenuates delayed cytoskeletal alterations and secondary axotomy following mild axonal stretch injury', Developmental Neurobiology, 67, (14) pp. 1831-1842. ISSN 1932-8451 (2007) [Refereed Article]

DOI: 10.1002/dneu.20552 [eCite] [Details]

Citations: Scopus - 16Web of Science - 19

Co-authors: Staal JA; Chung RS; Vickers JC

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2007Woodhouse A, Dickson TC, Vickers JC, 'Vaccination strategies for Alzheimer's disease: a new hope?', Drugs and Aging, 24, (2) pp. 107-119. ISSN 1170-229X (2007) [Refereed Article]

DOI: 10.2165/00002512-200724020-00003 [eCite] [Details]

Citations: Scopus - 22Web of Science - 21

Co-authors: Woodhouse A; Vickers JC

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2007Dickson TC, Chung RS, McCormack GH, Staal JA, Vickers JC, 'Acute reactive and regenerative changes in mature cortical axons following injury', Neuoreport, 18, (3) pp. 283-288. ISSN 0959-4965 (2007) [Refereed Article]

DOI: 10.1097/WNR.0b013e3280143cdb [eCite] [Details]

Citations: Scopus - 16Web of Science - 16

Co-authors: Chung RS; McCormack GH; Staal JA; Vickers JC

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2006Quilty MC, King AE, Gai WP, Pountney DL, West AK, et al., 'Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection', Experimental Neurology, 199, (2) pp. 249-256. ISSN 0014-4886 (2006) [Refereed Article]

DOI: 10.1016/j.expneurol.2005.10.018 [eCite] [Details]

Citations: Scopus - 70Web of Science - 62

Co-authors: Quilty MC; King AE; Gai WP; West AK; Vickers JC

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2006Woodhouse A, Dickson TC, West AK, McLean CA, Vickers JC, 'No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases', Neurobiology of Disease, 22, (2) pp. 323-333. ISSN 0969-9961 (2006) [Refereed Article]

DOI: 10.1016/j.nbd.2005.11.010 [eCite] [Details]

Citations: Scopus - 25Web of Science - 23

Co-authors: Woodhouse A; West AK; Vickers JC

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2006Woodhouse A, Vickers JC, Dickson TC, 'Cytoplasmic cytochrome c immunolabelling in dystrophic neurites in Alzheimer's disease', Acta Neuropathologica, 112, (4) pp. 429-437. ISSN 0001-6322 (2006) [Refereed Article]

DOI: 10.1007/s00401-006-0107-3 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Woodhouse A; Vickers JC

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2006King AE, Chung RS, Vickers JC, Dickson TC, 'Localisation of glutamate receptors in developing cortical neurons in culture and relationship to susceptibility to excitotoxicity', Journal of Comparative Neurology, 498, (2) pp. 277-294. ISSN 0021-9967 (2006) [Refereed Article]

DOI: 10.1002/cne.21053 [eCite] [Details]

Citations: Scopus - 39Web of Science - 38

Co-authors: King AE; Chung RS; Vickers JC

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2005Chung RS, Staal JA, McCormack GH, Dickson TC, Couzens M, et al., 'Mild axonal stretch injury in vitro induces a progressive series of neurofilament alterations ultimately leading to delayed axotomy', Journal of Neurotrauma, 22, (10) pp. 1081-1091. ISSN 0897-7151 (2005) [Refereed Article]

DOI: 10.1089/neu.2005.22.1081 [eCite] [Details]

Citations: Scopus - 41Web of Science - 38

Co-authors: Chung RS; Staal JA; McCormack GH; Chuckowree JA; Vickers JC

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2005Dickson TC, Chuckowree JA, Chuah MI, West AK, Vickers JC, 'α-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the α-amyloid plaques in inducing neuronal injury', Neurobiology of Disease, 18, (2) pp. 286-295. ISSN 0969-9961 (2005) [Refereed Article]

DOI: 10.1016/j.nbd.2004.10.001 [eCite] [Details]

Citations: Scopus - 33Web of Science - 32

Co-authors: Chuckowree JA; Chuah MI; West AK; Vickers JC

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2005Woodhouse A, West AK, Chuckowree JA, Vickers JC, Dickson TC, 'Does Beta-Amyloid Plaque Formation Cause Structural Injury to Neuronal Processes?', Neurotoxicity Research, 7, (1,2) pp. 5-15. ISSN 1029-8428 (2005) [Refereed Article]

DOI: 10.1007/BF03033772 [eCite] [Details]

Citations: Scopus - 13Web of Science - 11

Co-authors: Woodhouse A; West AK; Chuckowree JA; Vickers JC

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2004Chuckowree JA, Dickson TC, Vickers JC, 'Intrinsic Regenerative Ability of Mature CNS Neurons', Neuroscientist, 10, (4) pp. 280-285. ISSN 1073-8584 (2004) [Refereed Article]

DOI: 10.1177/1073858404263511 [eCite] [Details]

Citations: Scopus - 26Web of Science - 26

Co-authors: Chuckowree JA; Vickers JC

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2004Chung RS, Woodhouse A, Fung SJ, Dickson TC, West AK, et al., 'Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors', Cellular and Molecular Life Sciences, 61, (10) pp. 1238-1245. ISSN 1420-682X (2004) [Refereed Article]

DOI: 10.1007/s00018-004-4026-y [eCite] [Details]

Citations: Scopus - 80Web of Science - 66

Co-authors: Chung RS; Woodhouse A; Fung SJ; West AK; Vickers JC; Chuah MI

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2004Haas MA, Vickers JC, Dickson TC, 'Binding partners L1 cell adhesion molecule and the ezrin-radixin-moesin (ERM) proteins are involved in the development and the regenerative response to injury of hippocampal and cortical neurons', European Journal of Neuroscience, 20, (6) pp. 1436-1444. ISSN 0953-816X (2004) [Refereed Article]

DOI: 10.1111/j.1460-9568.2004.03620.x [eCite] [Details]

Citations: Scopus - 25Web of Science - 26

Co-authors: Haas MA; Vickers JC

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2003Mintz CD, Dickson TC, Gripp ML, Salton SRJ, Benson DL, 'ERMs Colocalize Transiently with L1 during Neurocortical Axon Outgrowth', Journal of Comparative Neurology, 464, (4) pp. 438-448. ISSN 0021-9967 (2003) [Refereed Article]

DOI: 10.1002/cne.10809 [eCite] [Details]

Citations: Scopus - 35Web of Science - 34

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2003Vickers JC, Tan A, Dickson TC, 'Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease', Brain Research, 971, (1) pp. 135-137. ISSN 0006-8993 (2003) [Refereed Article]

DOI: 10.1016/S0006-8993(03)02429-6 [eCite] [Details]

Citations: Scopus - 8Web of Science - 6

Co-authors: Vickers JC

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2002Dickson TC, Mintz CD, Benson DL, Salton SRJ, 'Functional binding interaction identified between the axonal CAM L1 members of the ERM family', Journal of Cell Biology, 157, (7) pp. 1105-1112. ISSN 0021-9525 (2002) [Refereed Article]

DOI: 10.1083/jcb.200111076 [eCite] [Details]

Citations: Scopus - 109Web of Science - 109

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2002Kirkcaldie MTK, Dickson TC, King CE, Grasby DJ, Riederer BM, et al., 'Neurofilament triplet proteins are restricted to a subset of neurons in the rat neocortex', Journal of Chemical Neuroanatomy, 24, (3) pp. 163-171. ISSN 0891-0618 (2002) [Refereed Article]

DOI: 10.1016/S0891-0618(02)00043-1 [eCite] [Details]

Citations: Scopus - 52Web of Science - 48

Co-authors: Kirkcaldie MTK; King CE; Vickers JC

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2001Dickson TC, Vickers JC, 'The morphological phenotype of a-amyloid plaques and associated neuritic changes in Alzheimers disease', Neuroscience, 105, (1) pp. 99-107. ISSN 0306-4522 (2001) [Refereed Article]

DOI: 10.1016/S0306-4522(01)00169-5 [eCite] [Details]

Citations: Scopus - 121Web of Science - 116

Co-authors: Vickers JC

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2000Dickson TC, Adlard PA, Vickers JC, 'Sequence of Cellular Changes Following Localized Axotomy to Cortical Neurons in Glia-Free Culture', Journal of Neurotrauma, 17, (11) pp. 1095-1103. ISSN 0897-7151 (2000) [Refereed Article]

DOI: 10.1089/neu.2000.17.1095 [eCite] [Details]

Citations: Scopus - 29Web of Science - 31

Co-authors: Vickers JC

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2000King CE, Adlard PA, Dickson TC, Vickers JC, 'Neuronal Response to Physical Injury and its Relationship to the Pathology of Alzheimer's Disease', Clinical and Experimental Pharmacology and Physiology, 27, (7) pp. 548-552. ISSN 0305-1870 (2000) [Refereed Article]

DOI: 10.1046/j.1440-1681.2000.03292.x [eCite] [Details]

Citations: Scopus - 13Web of Science - 15

Co-authors: King CE; Vickers JC

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2000King CE, Dickson TC, Jacobs I, McCormack GH, Riederer BM, et al., 'Acute CNS axonal injury models a subtype of dystrophic neurite in Alzheimer's Disease', Alzheimer's Reports, 3, (1) pp. 31-40. ISSN 1461-6130 (2000) [Refereed Article]

[eCite] [Details]

Citations: Scopus - 7Web of Science - 7

Co-authors: King CE; Jacobs I; McCormack GH; Vickers JC

2000Vickers JC, Aldard P, Dickson TC, King Carolyn, 'In vivo and in vitro experimental axotomy mimics a subtype of dystrophic neurite associated with beta-amyloid plaque formation in Alzheimer's disease', Neurobiology of Aging: Experimental and Clinical Research, 1, (Supp 1) pp. 89. ISSN 0197-4580 (2000) [Contribution to Refereed Journal]

DOI: 10.1016/S0197-4580(00)82624-X [eCite] [Details]

Co-authors: Vickers JC; King Carolyn

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2000Vickers JC, Dickson TC, Adlard PA, Saunders HL, King CE, et al., 'The Cause of Neuronal Degeneration in Alzheimer's disease', Progress in Neurobiology, 60, (2) pp. 139-165. ISSN 0301-0082 (2000) [Refereed Article]

DOI: 10.1016/S0301-0082(99)00023-4 [eCite] [Details]

Citations: Scopus - 185Web of Science - 169

Co-authors: Vickers JC; Saunders HL; King CE; McCormack GH

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1999Dickson TC, King CE, McCormack GH, Vickers JC, 'Neurochemical Diversity of Dystrophic Neurites in the Early and late Stages of Alzheimer's Disease', Experimental Neurology, 156, (1) pp. 100-110. ISSN 0014-4886 (1999) [Refereed Article]

DOI: 10.1006/exnr.1998.7010 [eCite] [Details]

Citations: Scopus - 88Web of Science - 81

Co-authors: King CE; McCormack GH; Vickers JC

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1998Kirov SM, Sanderson K, Dickson TC, 'Characterisation of a type IV pilus produced by Aeromonas caviae', Journal of Medical Microbiology, 47, (6) pp. 527-531. ISSN 0022-2615 (1998) [Refereed Article]

DOI: 10.1099/00222615-47-6-527 [eCite] [Details]

Citations: Scopus - 13Web of Science - 15

Co-authors: Kirov SM; Sanderson K

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1998Saunders HL, Dickson TC, Vickers JC, 'Immunolocalisation of beta-amyloid precursor protein to plaque-associated synaptic alterations in the early and late stages of Alzheimer's disease', Alzheimer's Reports, 1, (2) pp. 111-118. ISSN 1461-6130 (1998) [Refereed Article]

[eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Saunders HL; Vickers JC

1997Dickson TC, Saunders HL, Vickers JC, 'Relationship between apolipoprotein E and the amyloid deposits and dystrophic neurites of Alzheimer's disease', Neuropathology and Applied Neurobiology, 23, (6) pp. 483-491. ISSN 0305-1846 (1997) [Refereed Article]

DOI: 10.1111/j.1365-2990.1997.tb01325.x [eCite] [Details]

Citations: Scopus - 26Web of Science - 21

Co-authors: Saunders HL; Vickers JC

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1997King CE, Jacobs I, Dickson TC, Vickers JC, 'Physical damage to rat cortical axons mimics early Alzheimer's neuronal pathology', Neuroreport, 8, (7) pp. 1663-1665. ISSN 0959-4965 (1997) [Refereed Article]

PMID: 9189910 [eCite] [Details]

Citations: Scopus - 26Web of Science - 28

Co-authors: King CE; Jacobs I; Vickers JC

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Chapter in Book

(2 outputs)
YearCitationAltmetrics
2017Yap YC, Dickson TC, King AE, Breadmore MC, Guijt RM, 'Microfluidic Device for Studying Traumatic Brain Injury', Stem Cell Technologies in Neuroscience, Springer Science+Business Media, AK Srivastava, EY Snyder, YD Teng (ed), New York, United States, pp. 145-156. ISBN 978-1-4939-7022-3 (2017) [Research Book Chapter]

DOI: 10.1007/978-1-4939-7024-7_10 [eCite] [Details]

Co-authors: Yap YC; King AE; Breadmore MC; Guijt RM

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2015Southam KA, King AE, Blizzard CA, McCormack GH, Dickson T, 'A Novel In Vitro Primary Culture Model of the Lower Motor Neuron-Neuromuscular Junction Circuit', Microfluidic and Compartmentalized Platforms for Neurobiological Research, Springer, E Biffi (ed), United States, pp. 181-193. ISBN 978-1-4939-2509-4 (2015) [Other Book Chapter]

DOI: 10.1007/978-1-4939-2510-0_11 [eCite] [Details]

Citations: Scopus - 1

Co-authors: Southam KA; King AE; Blizzard CA; McCormack GH

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Conference Publication

(57 outputs)
YearCitationAltmetrics
2015Yap YC, Dickson TC, King AE, Guijt RM, Breadmore MC, 'Microfludic maze for studying the role of neuron-glia signalling in neuronal networks', MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 25-29 October, Gyeongju, South Korea, pp. 648-650. ISBN 978-097980648-3 (2015) [Refereed Conference Paper]

[eCite] [Details]

Co-authors: Yap YC; King AE; Guijt RM; Breadmore MC

2014Blizzard CA, Handley E, Dawkins E, Clark R, Fielder T, et al., 'Synaptic alterations in the TDP-A315T mouse model of Amyotrophic Lateral Sclerosis', 25th International Symposium on ALS/MND, 5-7 December, Brussels, Belgium (2014) [Conference Extract]

DOI: 10.3109/21678421.2014.960187/259 [eCite] [Details]

Co-authors: Blizzard CA; Handley E; Dawkins E; Clark R; Fielder T

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2014Yap YC, Dickson TC, King AE, Breadmore MC, Guijt RM, 'Microfluidic model for mild traumatic brain injury', Proceedings, The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 26-30 October 2014, San Antonio, Texas, United States, pp. 989-992. ISBN 978-0-9798064-7-6 (2014) [Non Refereed Conference Paper]

[eCite] [Details]

Co-authors: Yap YC; King AE; Breadmore MC; Guijt RM

2012Blizzard C, King AE, Vickers JC, Dickson TC, 'Site specific excitotoxicity: a model of amyotrophic lateral sclerosis', 32nd Annual Meeting Australian Neuroscience Society, January 2012, Gold Coast, Australia (2012) [Conference Extract]

[eCite] [Details]

Co-authors: Blizzard C; King AE; Vickers JC

2012Yap YC, Dickson TC, King AE, Breadmore MC, Guijt RM, 'Microfluidic culture platform for studying neuronal response to axonal stretch injury', Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, October 28 - November 1, 2012, Okinawa, Japan, pp. 1-13. ISSN 1932-1058 (2012) [Refereed Conference Paper]

DOI: 10.1063/1.4891098 [eCite] [Details]

Citations: Web of Science - 3

Co-authors: Yap YC; King AE; Breadmore MC; Guijt RM

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2012King AE, Mitew S, Kirkcaldie MTK, Vickers JC, Dickson TC, 'Investigating the role of inhibition in neurological disease', 32nd Annual Meeting Australian Neuroscience Society, January 2012, Gold Coast, Australia (2012) [Conference Extract]

[eCite] [Details]

Co-authors: King AE; Mitew S; Kirkcaldie MTK; Vickers JC

2012Southam K, Blizzard C, Vickers JC, Dickson TC, King AE, 'Modelling site specific excitotixicity in vitro', University of Tasmania Sharing Excellence in Research meeting, September 2012, Hobart, Australia (2012) [Conference Extract]

[eCite] [Details]

Co-authors: Southam K; Blizzard C; Vickers JC; King AE

2012Summers MJ, Valenzuela M, Summers JJ, Ritchie K, Dickson TC, et al., 'The Tasmanian Healthy Brain Study (THBS): Does late-life education prevent age-related cognitive decline and dementia?', Elsevier, 14-19 July 2012, Vancouver, pp. P147. ISSN 1552-5260 (2012) [Conference Edited]

[eCite] [Details]

Co-authors: Summers MJ; Summers JJ; Robinson AL; Vickers JC

2012Yap YC, Dickson TC, King AE, Breadmore MC, Guijt RM, 'Microfluidic culture platform for studying neuronal response to axonal stretch injury', 28th International Symposium on Microscale Bioseparations and Analyse, 21- 24 October 2012, Shanghai, China (2012) [Conference Extract]

[eCite] [Details]

Co-authors: Yap YC; King AE; Breadmore MC; Guijt RM

2012Yap YC, Dickson TC, King AE, Breadmore MC, Guijt RM, 'Lab on a chip for studying neuronal degeneration', 3rd Australia & New Zealand Micro/Nanofluidics and Bionano Symposium, 12-13 April 2012, New Zealand (2012) [Conference Extract]

[eCite] [Details]

Co-authors: Yap YC; King AE; Breadmore MC; Guijt RM

2012Blizzard C, King AE, Hosie KA, Dickson TC, 'Site-specific excitotoxin exposure in vivo leads to neuronal excitotoxicity and axonal dysfunction', 32nd Annual Meeting Australian Neuroscience Society, January 2012, Gold Coast, Australia (2012) [Conference Extract]

[eCite] [Details]

Co-authors: Blizzard C; King AE; Hosie KA

2012King AE, Blizzard C, Mitew S, Dickson TC, 'Investigating the role of interneurons in neurological disease', DANDIS, January, 2012, Queensland, Australia (2012) [Conference Extract]

[eCite] [Details]

Co-authors: King AE; Blizzard C; Mitew S

2011Blizzard C, King AE, Hosie KA, Dickson TC, 'Modelling site-specific excitotoxicity in vivo', 22nd International Symposium on ALS/MND, November 2011, Sydney, Australia (2011) [Conference Extract]

[eCite] [Details]

Co-authors: Blizzard C; King AE; Hosie KA

2011Hosie KA, King AE, Blizzard C, Vickers JC, Dickson TC, 'Modelling ALS pathology in vitro', 22nd Symposium on ALS/MND, November 2011, Sydney, Australia (2011) [Conference Extract]

[eCite] [Details]

Co-authors: Hosie KA; King AE; Blizzard C; Vickers JC

2011King AE, Hosie KA, Vickers JC, Blizzard C, Dickson TC, 'An in vitro investigation of the role of interneurons in the development of ALS', 22nd Symposium on ALS/MND, November 2011, Sydney, Australia (2011) [Conference Extract]

[eCite] [Details]

Co-authors: King AE; Hosie KA; Vickers JC; Blizzard C

2011Yap YC, Dickson TC, King AE, Breadmore MC, Guijt RM, 'Lab-on-a-chip: A novel in vitro model for studying traumatic brain injury', Proceedings of the 11th Asia Pacific International Symposium on Microscale Separations and Analysis, November 2011, Hobart, Australia (2011) [Conference Extract]

[eCite] [Details]

Co-authors: Yap YC; King AE; Breadmore MC; Guijt RM

2011Hadrill CE, Gasperini RJ, Dickson TC, Foa LC, Small DH, 'Regulation of the cell adhesion molecule, L1CAM by the Aβ peptide of Alzheimer's Disease', Australian Neuroscience Society 31st Annual Meeting, 31 Jan - 3 Feb, Auckland, New Zealand (2011) [Conference Extract]

[eCite] [Details]

Co-authors: Hadrill CE; Gasperini RJ; Foa LC; Small DH

2010Blizzard CA, Chuckowree JA, King AE, Hosie KA, Chapman JA, et al., 'Focal damage to the neocortex induces dendritic structural plasticity', Australian Neuroscience Society/Australian Physiological Society, January, Sydney, Australia (2010) [Conference Extract]

[eCite] [Details]

Co-authors: Blizzard CA; Chuckowree JA; King AE; Hosie KA; Chapman JA; Vickers JC

2010Blizzard CA, Chuckowree JA, King AE, Hosie KA, Chapman JA, et al., 'Focal damage to the neocortex induces dendritic structural plasticity', Proceedings of the Dementia, Ageing and Neurodegenerative Diseases Group Conference 2010, 30 January 2010, Sydney, Australia (2010) [Conference Extract]

[eCite] [Details]

Co-authors: Blizzard CA; Chuckowree JA; King AE; Hosie KA; Chapman JA; Vickers JC

2010Dickson TC, King AE, Vickers JC, 'Neurodegeneration in ALS and AD: which comes first the axon or the soma?', Australian Neuroscience Society Conference, 31 January - 3 February, Sydney (2010) [Conference Extract]

[eCite] [Details]

Co-authors: King AE; Vickers JC

2010Mitew S, Kirkcaldie MTK, Halliday GE, Shepherd CE, Vickers JC, et al., 'Focal demyelination in Alzheimer's disease and transgenic mouse models', Gordon Conference on Myelin, California (2010) [Conference Extract]

[eCite] [Details]

Co-authors: Mitew S; Kirkcaldie MTK; Vickers JC

2009Blizzard CA, Chuckowree JA, King AE, McCormack GH, Chapman JA, et al., 'Acute neocortical injury induces axonal sprouting and dendritic remodelling', ASMR National Scientific Conference, Neurogenetics on the Apple Isle, February, Hobart (2009) [Conference Extract]

[eCite] [Details]

Co-authors: Blizzard CA; Chuckowree JA; King AE; McCormack GH; Chapman JA; Vickers JC

2009Dickson TC, King AE, Kirkcaldie MTK, Hosie K, Chung RS, et al., 'Novel alpha-internexin pathological alterations in both the spinal cord and brain of the G93A SOD1 model of amytrophic lateral sclerosis', Society for Neuroscience, 17-21 Oct, Chicago, pp. 304.13. (2009) [Conference Extract]

[eCite] [Details]

Co-authors: King AE; Kirkcaldie MTK; Hosie K; Chung RS; Vickers JC

2009Dickson TC, King AE, Kirkcaldie MTK, Hosie K, Vickers JC, 'Novel alpha-internexin pathological alterations in both the spinal cord and forebrain of the G93A SOD1 model of Amyotrophic Lateral Sclerosis', Australian Society for Medical Research, 15-17 November, Hobart, Tasmania (2009) [Conference Extract]

[eCite] [Details]

Co-authors: King AE; Kirkcaldie MTK; Hosie K; Vickers JC

2009King AE, Dickson TC, Vickers JC, 'Investigating the cause and consequence of axonal pathology in amyotrophic lateral sclerosis', DANDIS Conference, Australian Neuroscience Society, 27 January, Canberra (2009) [Conference Extract]

[eCite] [Details]

Co-authors: King AE; Vickers JC

2009King AE, Hosie K, Staal JA, Musgrove R, Vickers JC, et al., 'Microfluidic investigation of excitotoxin induced ALS-like axonal degeneration', ALS and Other Motor Neuron Disorders, 20th Symposium on ALS/MND, 8-10 December, Berlin, pp. 102. (2009) [Conference Extract]

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Co-authors: King AE; Hosie K; Staal JA; Musgrove R; Vickers JC

2009Musgrove R, King AE, Dickson TC, 'Alpha-synuclein is a potential neuroprotectant in both wild-type cortical and dopaminergic neurons, but not A53T mutant neurons', 9th International Conference AD/PD, 11-15 March, Prague, Czech Republic (2009) [Conference Extract]

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Co-authors: Musgrove R; King AE

2009Musgrove R, King AE, Dickson TC, 'Alpha-synuclein upregulation is a neuroprotective response of dopaminergic and cortical neurons', Australian Society for Medical Research, 15-17 November, Hobart, Tasmania (2009) [Conference Extract]

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Co-authors: Musgrove R; King AE

2009Vickers JC, Staal JA, Gasperini RJ, Foa LC, Liu Y, et al., 'Axonal stretch injury in vitro results in initial release of calcium from intracellular stores, prolonged calcium mismetabolism and secondary degeneration', Society for Neuroscience, 17-21 Oct, Chicago, pp. 214.2. (2009) [Conference Extract]

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Co-authors: Vickers JC; Staal JA; Gasperini RJ; Foa LC; Liu Y

2008Blizzard C, Chuckowree JA, McCormack GH, Chapman JA, King AE, et al., 'Delayed morphological alterations in a subpopulation of interneurons in the peri-wound region following focal damage to the adult rat neocortex', Neuroscience, 15-19 November 2008, Washington DC (2008) [Conference Extract]

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Co-authors: Blizzard C; Chuckowree JA; McCormack GH; Chapman JA; King AE; Vickers JC

2008King AE, Dickson TC, Blizzard CA, Foster SS, Woodhouse A, et al., 'Neuron-glia interactions underlying axonal health in an in vitro spinal culture model of relevance to ALS', Amyotrophic Lateral Sclerosis, 19th Symposium on ALS/MND, 3-5 November, Birmingham, pp. 85. (2008) [Conference Extract]

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Co-authors: King AE; Blizzard CA; Foster SS; Woodhouse A; Chung RS; Vickers JC

2008Vickers JC, King AE, Chung RS, Foster S, West AK, et al., 'Axonopathy, excitotoxicity and neuronal degeneration in ALS 2008', Australian Neuroscience Society Conference, 27-30 January, Hobart (2008) [Conference Extract]

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Co-authors: Vickers JC; King AE; Chung RS; Foster S; West AK; Chuah MI

2008Woodhouse A, Carroll VL, Sokolova A, Shepherd CE, Halliday G, et al., 'Presenilin-1 familial Alzheimer's disease cases exhibit altered pathology in comparison to sporadic AD', Proceedings of the Australian Neuroscience Society Annual Conference 2008, 27-30 January 2008, Hobart, pp. 113. (2008) [Conference Extract]

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Co-authors: Woodhouse A; Sokolova A; Shepherd CE; Halliday G; Vickers JC

2008Vickers JC, King AE, Blizzard CA, Woodhouse A, Foster SS, et al., 'Murine spinal neurons in vitro develop proximal axonal transport abnormalities and swellings that are similar to early axonal changes in amyotrophic lateral sclerosis', Society for Neuroscience, 15-19 November, Washington, DC (2008) [Conference Extract]

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Co-authors: Vickers JC; King AE; Blizzard CA; Woodhouse A; Foster SS; Chung RS

2007King AE, Dickson TC, Blizzard CA, Foster SS, Chung RS, et al., 'ALS-like pathology in cultured spinal motor neurons following excitoxicity', IBRO International Conference, 12-17 July, Melbourne (2007) [Conference Extract]

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Co-authors: King AE; Blizzard CA; Foster SS; Chung RS; West AK; Chuah MI; Vickers JC

2007King AE, Dickson TC, Blizzard CA, Foster SS, Chung RS, et al., 'ALS-like axonal pathology in cultured spinal motor neurons', Amyotrophic Lateral Sclerosis, 18th Symposium on ALS/MND, 1-3 December, Toronto, pp. 191. (2007) [Conference Extract]

[eCite] [Details]

Co-authors: King AE; Blizzard CA; Foster SS; Chung RS; West AK; Chuah MI; Vickers JC

2007Woodhouse A, Vickers JC, Adlard PA, Dickson TC, 'The dystrophic neurite pathology exhibited by TgCRND8 and Tg2576 transgenic mice models preclinical Alzheimer's disease', IBRO World Congress of Neuroscience, Melbourne (2007) [Conference Extract]

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Co-authors: Woodhouse A; Vickers JC

2007Woodhouse A, Vickers JC, Adlard PA, Dickson TC, 'Plaque-induced axonal pathology in transgenic mice expressing human mutant amyloid precursor protein genes replicates the dystrophic neurites characteristic of preclinical AD', Society for Neuroscience, San Diego (2007) [Conference Extract]

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Co-authors: Woodhouse A; Vickers JC

2006King AE, Chung RS, Vickers JC, Dickson TC, 'Relationship between the developmental localisation of glutamate receptor subunits in vitro and susceptibility to excitotoxicity', Australian Neuroscience Society Conference, 31 January - 3 February, Sydney (2006) [Conference Extract]

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Co-authors: King AE; Chung RS; Vickers JC

2006Vickers JC, King AE, Dickson TC, Chung RS, Chuckowree JA, et al., 'In vitro models of the key pathological changes in axons associated with neurodegenerative disease and acquired brain injury', 4th Congress of Federation of Asian-Oceanain Neuroscience Societies, November, Hong Kong (2006) [Conference Extract]

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Co-authors: Vickers JC; King AE; Chung RS; Chuckowree JA; Haas MA; Staal JA; Woodhouse A; Blizzard C; West AK; Chuah I; McCormack G

2006Woodhouse A, Adlard PA, Dickson TC, Vickers JC, 'Mutant human APP transgenic mice demonstrate dystrophic neurite pathology identical to preclinical Alzheimer's disease', Congress of the Federation of the Asian-Oceanian Neuroscience Societies, Hong Kong (2006) [Conference Extract]

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Co-authors: Woodhouse A; Vickers JC

2005Haas MA, Chung RS, Chuckowree JA, Vickers JC, Dickson TC, 'A role for ERM proteins and extracellular guidance cues in neuronal movement and the response to trauma', 35th Annual Meeting of the Society for Neuroscience, November, Washington, DC, USA (2005) [Conference Extract]

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Co-authors: Haas MA; Chung RS; Chuckowree JA; Vickers JC

2005Vickers JC, Chuckowree JA, Dickson TC, 'Brain healing following localised cortical injury involves restructuring of neural cytoarchitecture', 35th Annual Meeting of the Society for Neuroscience, November, Washington, DC, USA (2005) [Conference Extract]

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Co-authors: Vickers JC; Chuckowree JA

2005Woodhouse A, Dickson TC, West AK, Vickers JC, 'Proteins and genes related to apoptosis are not elevated in pathological brain aging or Alzheimer's disease', Society for Neuroscience, Washington DC (2005) [Conference Extract]

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Co-authors: Woodhouse A; West AK; Vickers JC

2004Chuckowree JA, Dickson TC, Chopin S, McCormack GH, Vickers JC, 'Focal injury to the mature rat neocortex: The fate of nestin immunoreactive cells', Proceedings of the 22nd Meeting of the Australian Neuroscience Society Conference, January, Melbourne, Australia, pp. 1. (2004) [Conference Extract]

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Co-authors: Chuckowree JA; Chopin S; McCormack GH; Vickers JC

2004Chuckowree JA, Dickson TC, West AK, Vickers JC, 'Alterations in α-internexin distribution in Alzheimer's disease and experimental models of neuronal trauma', 1st Meeting of Dementia, Ageing and Neurodegenerative Disease Group, January, Melbourne, Australia (2004) [Conference Extract]

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Co-authors: Chuckowree JA; West AK; Vickers JC

2004Haas MA, Vickers JC, Foa LC, Dickson TC, 'L1 and ERM proteins are involved in regenerative sprouting following neuronal trauma in vitro', 34th Annual Meeting for the Society for Neuroscience, San Diego, pp. 391.17. (2004) [Conference Extract]

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Co-authors: Haas MA; Vickers JC; Foa LC

2004Vickers JC, Chuckowree JA, Chuah MI, West AK, Dickson TC, 'Alpha-internexin in Alzheimer's disease pathology demonstrates hierarchy of neuronal degeneration and neuropathic role of plaque formation', 34th Annual Meeting of the Society for Neuroscience, November, San Diego, USA (2004) [Conference Extract]

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Co-authors: Vickers JC; Chuckowree JA; Chuah MI; West AK

2004Vickers JC, Dickson TC, Chuckowree JA, Chung RS, West AK, et al., 'The link between cellular changes associated with axonal injury and Alzheimer's Disease', The International Neurotrauma Symposium, 2004, pp. 79. (2004) [Conference Extract]

[eCite] [Details]

Co-authors: Vickers JC; Chuckowree JA; Chung RS; West AK; Chuah MI

2004Chuckowree JA, Dickson TC, McCormack GH, Chuah MI, Vickers JC, 'The brain response to injury involves mobilization of nestin progenitors and axonal sprouting', 34th Annual Meeting of the Society for Neuroscience, November, San Diego, USA (2004) [Conference Extract]

[eCite] [Details]

Co-authors: Chuckowree JA; McCormack GH; Chuah MI; Vickers JC

2000Vickers JC, Adlard PA, Coleman B, Dickson TC, Jacobs I, et al., 'Reactive and Regenerative Changes Following in vivo and in vitro Experimental Axotomy of Mature Cortical Neurons', Restorative Neurology and Neuroscience, 1 - 5 October, 2000, Garmisch-Partenkirchen, Germany, pp. 185. (2000) [Conference Extract]

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Co-authors: Vickers JC; Jacobs I; King CE

1999Dickson TC, Adlard PA, Vickers JC, 'Development of an in vitro model of cortical axonal injury', Proceedings of the 19th Annual Meeting of the Australian Neuroscience Society, 31/1-3/2/1999, Hobart, Tasmania, pp. 35. (1999) [Conference Extract]

[eCite] [Details]

Co-authors: Vickers JC

1999King CE, Dickson TC, Vickers JC, 'Colocalisation of neurofilament epitopes within damaged axons in an animal model of Azheimer's disease', Proceedings of the 19th Annual Meeting of the Australian Neuroscience Society, 31 January - 3 February 1999, Hobart, Tasmania, pp. 214. (1999) [Conference Extract]

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Co-authors: King CE; Vickers JC

1998Dickson TC, Vickers JC, 'Neurochemical diversity of the dystrophic neurites of aging and Alzheimer's disease', 37th Annual Meeting of the Australian Society for Medical Research, 22-25 November, Hobart, Tasmania, pp. 61. (1998) [Conference Extract]

[eCite] [Details]

Co-authors: Vickers JC

1998Dickson TC, Vickers JC, 'Neurochemical diversity of the dystrophic neurites of aging and Alzheimer's disease', 28th Annual Meeting of the Society for Neuroscience, 7-12 Novemeber, Los Angeles, California, pp. 960. (1998) [Conference Extract]

[eCite] [Details]

Co-authors: Vickers JC

1998Dickson TC, Vickers JC, 'Staging of the development of dystrophic neurites in Alzheimer's disease', Proceeding of the Australian Neuroscience Society, 27-30 January, Canberra, ACT, pp. 202. ISSN 1034-3237 (1998) [Conference Extract]

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Co-authors: Vickers JC

1995Dickson TC, Sanderson K, Kirov SM, 'Re-evaluation of Aeromonas caviae as a gastrointestinal pathogen', Australian Microbiologist, Adelaide, South Australia, pp. No number. (1995) [Conference Extract]

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Co-authors: Sanderson K; Kirov SM

Thesis

(1 outputs)
YearCitationAltmetrics
2000Dickson TC, 'The Cellular Mechanism Underlying Neuronal Changes in Alzheimer's Disease' (2000) [PhD]

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Grants & Funding

Funding Summary

Number of grants

54

Total funding

$6,918,412

Projects

Literature review on 3Rs (the replacement, reduction and refinement of the use of animals for scientific purposes) (2017)$57,873
Description
Conduct a systematic search of Australian and international literature relevant to the 3Rs, and critically evaluate it in order to develop a report on what is happening internationally and in Australia in relation to the 3Rs, the current gaps in knowledge, enablers and barriers to development and adoption in Australia.
Funding
National Health & Medical Research Council ($57,873)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Winzenberg TM; Dickson TC; Sharman MJ; Makin JK
Year
2017
Research Enhancement Program 2017 (2017)$38,250
Description
TBA by Institute
Funding
University of Tasmania ($38,250)
Scheme
Grant- Research Enhancement Program
Administered By
University of Tasmania
Research Team
Dickson TC
Year
2017
Preclinical Development of Neuropeptide Y for the Treatment of Motor Neuron Disease (2017 - 2020)$936,575
Description
Motor Neuron Disease (MND) is a rapidly progressing neurodegenerative disease. There are no cures and no effective treatments for MND, with people diagnosed having a median survival of only three years from symptom onset. Not knowing the cause of MND or how it progresses through the CNS have been immense barriers to the development of effective therapeutics. We have reached a critical time in MND research. Our research team has been dedicated to researching the mechanism of MND for the last ten years. We are now poised to transition my teams research efforts from determining the cause of this disease to using this knowledge to develop treatments. A critical pathway that our work and others have shown is key to MND is altered network excitability and subsequent excitotoxicity in the cortex. We have recent published and preliminary data that identifies that a critical potential point of intervention in this pathway is via the subclass of inhibitory cells that express neuropeptide Y (NPY). The overarching Aim for this Cure for MND Translational Research Grant is to now target this pathway to develop a treatment. By performing this world-first preclinical trial we will reveal further aspects of disease pathogenesis. Positive outcomes from these trials will identify a candidate compounds for progression to a human trial for the treatment of MND.
Funding
The Cure for MND Foundation ($936,575)
Scheme
Grant-Translational Research Grant
Administered By
University of Tasmania
Research Team
Dickson TC; Blizzard C; Pebay A; Walker A; Blizzard CL; Rogers M; Hewitt A; Zosky GR
Period
2017 - 2020
A genome-wide analysis of the epigenetic control of learning and memory (2017 - 2019)$547,857
Description
The ability to form and recall memories is a fundamental function of the brain. This ability is affected by neurodegenerative diseases such as Alzheimer's Disease. This project will uncover the regulatory framework that defines the brain cells involved in forming memories, and how these change during Alzheimer's Disease progression.
Funding
National Health & Medical Research Council ($547,857)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Marshall O; Dickson TC; Southall T
Period
2017 - 2019
Grant Reference
1128784
Confocal microscope: a new high-speed confocal microscope to enable rapid image capture and analysis (2016)$250,000
Description
Donation to Tracey Dickson and group for the purchase of a confocal microscope
Funding
The Select Foundation ($250,000)
Scheme
Donation - Individual
Administered By
University of Tasmania
Research Team
Dickson TC
Year
2016
Investigating synaptic dysfunction in ALS (2016)$99,767
Description
Amyotrophic Lateral Sclerosis (ALS) is incurable, caused by the death of motor neurons in the cortex and spinal cord. There is a desperate need to discover new therapeutic ways to stop this neuron death, ideally targeted at early changes in the disease to prevent the majority of cell loss. There is growing evidence that neuronal dysfunction in the cortex is occurring in ALS well before symptoms present. Disturbances in neuronal synapses may be one such early event that potentially leads to neuronal dysfunction and then death. Changes in synapses can have serious effects on neurons activity levels and if not controlled can cause neuron death. The RNA binding protein TDP-43 is likely to play a critical role in ALS as inappropriate localization of this protein is frequent in the disease and mutations in TDP-43 causes a genetic form of ALS. We have found that TDP-43 involved in maintaining synapses between neurons; regulating the number and maturation of spines. It is feasible that an early disease-causing event in ALS may be changes to synapses. We will investigate how different mutations of the TDP-43 protein determine the number and composition of spines as it happens in upper motor neurons of the cortex. This novel research program addresses an important gap in the current understanding of how synaptic changes can lead to neuron death in ALS and may open up a new target for drug intervention in this devastating disease.
Funding
Motor Neurone Disease Research Institute of Australia Inc ($99,767)
Scheme
Grant-In-Aid
Administered By
University of Tasmania
Research Team
Blizzard C; Dickson TC
Year
2016
Inhibitory dysfunction in the cortex: Tackling MND from the top down (2016)$248,916
Funding
Motor Neurone Disease Research Institute of Australia Inc ($248,916)
Scheme
Standford Family MND Collaboration Grant
Administered By
University of Tasmania
Research Team
Dickson TC; Young Kaylene; Bekkers J
Year
2016
INTERNEURON DYSFUNCTION in ALS: A SYSTEMATIC HUMAN PATHOLOGY ANALYSIS (2016)$93,346
Description
Motor neuron hyperexcitability and excitotoxicity have both been implicated as key mediators of ALS pathophysiology, however limited research has investigated the very real possibility that inhibitory interneuron dysfunction initiates this process. Interneurons are powerful modulators of motor neuron function in the cortex and the spinal cord, and new clinical, histological and electrophysiological evidence, from our research team and others, indicates that reduced inhibitory neuronal influences may directly disturb glutamatergic transmission in ALS. In the current proposal we will perform detailed and systematic human pathological investigations to address the hypothesis: interneuron and/or inhibitory pathogenesis precedes motor neuron hyperexcitability and pathology and causes ALS.
Funding
Motor Neurone Disease Research Institute of Australia Inc ($93,346)
Scheme
Jenny Simko MND Research Grant
Administered By
University of Tasmania
Research Team
Dickson TC; Turner Martin
Year
2016
Microfluidic technology to help understand physical damage to brain cells (2015 - 2017)$415,500
Description
Understanding the organisation, structure and mechanisms of the human brain and nervous system remains one of the biggest challenges of science. This project will develop a new cell culture platform to form defined molecular networks of brain cells and to monitor changes throughout the network in response to a small localised injury within the network. This innovative platform will be used to help understand changes within cells in response to physical damage to networks of brain cells. This is one of the major causes of death and disability in developed nations, and is identified as a risk factor for a range of neurodegenerative diseases including Alzheimer's, Parkinson's and motor neuron disease.
Funding
Australian Research Council ($415,500)
Scheme
Grant-Discovery Projects
Administered By
University of Tasmania
Research Team
Breadmore MC; Guijt RM; Dickson TC; King AE
Period
2015 - 2017
Grant Reference
DP150100998
SYNAPTIC DYSFUNCTION: AN EARLY MECHANISM OF TDP-43 PATHOGENESIS IN ALS? (2015)$94,848
Description
Amyotrophic Lateral Sclerosis (ALS) is a devastating disease that is caused by the death of motor neurons. There is a desperate need to discover new therapeutic ways to stop this neuron death, ideally targeted at early changes in the disease to prevent the majority of cell loss. Disturbances in neuronal synapses may be one such early event that potentially leads to neuronal dysfunction and then death. Synapses are specialised structures that allow neurons to communicate with each other. Changes in synapses can have serious effects on neurons activity levels and if not controlled can cause neuron death. Mutations in the protein, transactive response DNA-binding protein 43 (TDP-43) causes a genetic form of ALS. TDP-43 has recently been shown to be involved in maintaining synapses between neurons; regulating the number and maturation of spines. It is feasible that an early disease-causing event in ALS may be changes to synapses. This project will investigate how different mutations of the TDP-43 protein determines the number and composition of synapses in vitro using specialised compartmentalised primary neuronal cultures. This novel research program addresses an important gap in the current understanding of how synaptic changes can lead to neuron death in ALS and may open up a new target for drug intervention in this devastating disease.
Funding
Motor Neurone Disease Research Institute of Australia Inc ($94,848)
Scheme
Grant-In-Aid
Administered By
University of Tasmania
Research Team
Blizzard C; Dickson TC
Year
2015
INHIBITORY REGULATION OF MOTOR NEURONS: A NEW TARGET MECHANISM FOR ALS ? (2015)$86,329
Description
There is considerable evidence from many areas of clinical and basic medical research that in MND motor neurons may be dying due to a toxicity that is triggered due to their over activity known as excitotoxicity. There is new evidence that this toxic cascade may initially be triggered by the death or dysfunction of another type of neuron in the brain the interneuron. Interneurons are critical regulators of motor neuron activity and modulators of the balance that is essential for normal brain function. Research has developed a method of specifically growing interneurons and/or motor neurons, derived from transgenic mice developed to model MND, in primary culture. This highly specific brain in a dish approach will allow us to determine if the presence of abnormal or pathogenic interneurons can lead to abnormal motor neuron function and pathology. Not only would these studies provide important insight into the mechanisms responsible for ALS, but they would also provide a high throughput model for later assessing potential therapeutic interventions.
Funding
Motor Neurone Disease Research Institute of Australia Inc ($86,329)
Scheme
Grant-In-Aid
Administered By
University of Tasmania
Research Team
Dickson TC; King AE
Year
2015
Dendritic spine alterations in TDP-43 aggregated frontotemporal dementia: a novel therapeutic target? (2014)$35,000
Description
Frontotemporal dementia is a devastating disease affecting primarily the frontal and temporal part of the brain. It is the second most common form of dementia in people under the age of 65. In FTD proteins that play important functional roles in neurons inappropriately aggregate in the neuronal cyoplasm. This causes the neurons to stop working properly and eventually die. One protein that has been identified to do this is the transactive response DNA-binding protein 43 (TDP-43). The function of the protein is unknown. Understanding its function could provide clues as to what is causing FTD.
Funding
Brain Foundation ($35,000)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Blizzard C; Dickson TC
Year
2014
Synaptic alterations in ALS: A novel therapeutic target? (2014)$84,971
Description
This novel research program addresses an important gap in the new current understanding of how synaptic changes can lead to neuron death in ALS and may open up a new target for drug intervention in this devastating disease.
Funding
Motor Neurone Disease Research Institute of Australia Inc ($84,971)
Scheme
Grant-In-Aid
Administered By
University of Tasmania
Research Team
Blizzard C; Dickson TC
Year
2014
Interneuron dysfunction in Amyotrophic Lateral Sclerosis: A new target for potential therapeutics? (2013 - 2015)$30,000
Funding
Motor Neurone Disease Research Institute of Australia Inc ($30,000)
Scheme
Scholarship-PhD Top-Up Grant
Administered By
University of Tasmania
Research Team
Clark RM; Dickson TC
Period
2013 - 2015
Targeted axonal protection in Amyotrophic Lateral Sclerosis (2013 - 2015)$30,000
Funding
Motor Neurone Disease Research Institute of Australia Inc ($30,000)
Scheme
Scholarship-PhD Top-Up Grant
Administered By
University of Tasmania
Research Team
Dickson TC; Clark JA
Period
2013 - 2015
Microtubule stabilisation: promoting adaptive plasticity, brain healing and functional recovery after traumatic brain injury (2013 - 2015)$490,419
Funding
National Health & Medical Research Council ($490,419)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Dickson TC
Period
2013 - 2015
Grant Reference
1042556
Interneuron dysfunction in Amyotrophic Lateral Sclerosis: A new target for potential therapeutics? (2013)$83,435
Funding
Motor Neurone Disease Research Institute of Australia Inc ($83,435)
Scheme
Grant-in-Aid Zo-ee MND Research
Administered By
University of Tasmania
Research Team
Dickson TC; King AE
Year
2013
Axonal protection in ALS (2013)$78,307
Funding
Motor Neurone Disease Research Institute of Australia Inc ($78,307)
Scheme
Grant-In-Aid
Administered By
University of Tasmania
Research Team
King AE; Blizzard C; Dickson TC
Year
2013
Establishing a state-of-the-art 'Live Cell Recording and Imaging Facility' at Menzies Research Institute Tasmania (2013)$22,000
Funding
Rebecca L Cooper Medical Research Foundation ($22,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Young Kaylene; Small DH; Foa LC; Dickson TC
Year
2013
Differential vulnerability of interneurons to trauma and disease (2012)$4,830
Funding
The Select Foundation ($4,830)
Scheme
Grant-Small Grants Scheme
Administered By
University of Tasmania
Research Team
Dickson TC
Year
2012
Neural regulation of skeletal muscle insulin sensitivity (2012)$9,825
Funding
The Select Foundation ($9,825)
Scheme
Grant-Small Grants Scheme
Administered By
University of Tasmania
Research Team
Rattigan S; Keske MAV; Dickson TC
Year
2012
Determining the mechanism underlying post-operative cognitive decline (2012)$6,508
Funding
Royal Hobart Hospital Research Foundation ($6,508)
Scheme
Grant-Starter
Administered By
University of Tasmania
Research Team
Terblanche N; Blizzard C; King AE; Dickson TC; Skinner MW; Vickers JC
Year
2012
Visualising the brain's response to trauma as it happens: Working towards improved outcomes after traumatic brain injury (2011 - 2012)$62,000
Funding
MAIB Injury Prevention & Management Foundation ($62,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Chuckowree JA; Dickson TC
Period
2011 - 2012
Visualising the brain's response to trauma as it happens: working towards improved outcomes after traumatic brain injury (2011)$23,636
Funding
The Marian and EH Flack Trust ($23,636)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Chuckowree JA; Dickson TC
Year
2011
The role of excitotoxicity in mediating distal axonal degeneration in ALS (2011 - 2013)$379,034
Funding
National Health & Medical Research Council ($379,034)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Dickson TC; Vickers JC; Chung RS; King AE
Period
2011 - 2013
Grant Reference
1003931
A Lab on a Chip for Stressing Neurons (2011)$19,956
Funding
University of Tasmania ($19,956)
Scheme
Grant-Cross Theme
Administered By
University of Tasmania
Research Team
Guijt RM; Dickson TC; Breadmore MC
Year
2011
The inhibition of malignant glioma proliferation using novel taxol-like derivatives that are capable of crossing the blood-brain barrier (2011)$14,000
Funding
Cancer Council of Tasmania ($14,000)
Scheme
Grant-Small
Administered By
University of Tasmania
Research Team
Dickson TC; Staal JA
Year
2011
Focal demyelination in Alzheimer's disease (2011 - 2013)$322,524
Funding
National Health & Medical Research Council ($322,524)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Vickers JC; Dickson TC; Staal JA; West AK
Period
2011 - 2013
Grant Reference
1011156
An innovative platform for studying the dynamic repertoire of the neural response to brain injury: Identifying novel therapeutic targets (2010)$30,000
Funding
Brain Foundation ($30,000)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Chuckowree JA; Dickson TC
Year
2010
Targeting Axonal Dysfunction in Amyotrophic Lateral Sclerosis (2010)$25,000
Funding
University of Tasmania ($25,000)
Scheme
Grant-Near Misses
Administered By
University of Tasmania
Research Team
Dickson TC
Year
2010
Focal Demyelination in Alzheimer's disease (2010)$40,000
Funding
The Mason Foundation ($40,000)
Scheme
Grant-Judith Jane Mason & Harold Stannett Williams
Administered By
University of Tasmania
Research Team
Dickson TC
Year
2010
Using engineered tissue and magnetic resonance spectroscopy to investigate human muscle function and metabolism (2010)$29,026
Funding
The MAWA Trust ($29,026)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Edwards LM; Dickson TC
Year
2010
Determining novel biomarkers of nerve cells undergoing secondary degeneration following traumatic brain injury (2010)$24,000
Funding
MAIB Injury Prevention & Management Foundation ($24,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Dickson TC; Staal JA
Year
2010
Rising Stars Programme - Tracey Dickson (2009 - 2011)$66,260
Funding
University of Tasmania ($66,260)
Scheme
Grant-Rising Stars Round 1
Administered By
University of Tasmania
Research Team
Dickson TC
Period
2009 - 2011
The role of distal axonal degeneration in ALS (2009)$27,360
Funding
Motor Neurone Disease Research Institute of Australia Inc ($27,360)
Scheme
Grant-In-Aid
Administered By
University of Tasmania
Research Team
King AE; Vickers JC; Dickson TC
Year
2009
Determining the cellular mechanism underlying diffuse axonal injury following traumatic brain trauma (2009 - 2011)$385,125
Funding
National Health & Medical Research Council ($385,125)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Vickers JC; Dickson TC
Period
2009 - 2011
Grant Reference
544925
Cellular mechanisms underlying neurodegenerative disease and responses to trauma (2008 - 2011)$362,000
Funding
National Health & Medical Research Council ($362,000)
Scheme
Fellowship-Career Development Award
Administered By
University of Tasmania
Research Team
Dickson TC
Period
2008 - 2011
Grant Reference
490047
Establishment of a Confocal/multiphoton Microscope for Imaging of Living Systems (2008)$300,000
Funding
Australian Research Council ($300,000)
Scheme
Grant-Linkage Infrastructure
Administered By
University of Tasmania
Research Team
Vickers JC; Foote SJ; Small DH; Walters EH; Hallegraeff GM; West AK; Chung RS; Woods GM; Dickson TC; Nowak BF; Bolch CJS
Year
2008
Grant Reference
LE0882701
The Neuroprotective Properties of Alpha-Synuclein (2007 - 2009)$310,250
Funding
National Health & Medical Research Council ($310,250)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Dickson TC; Vickers JC
Period
2007 - 2009
Grant Reference
457621
Alzheimer's disease: amyloid plaques 'mass effect' leads to neurodegeneration and dementia (2007)$13,636
Funding
Royal Hobart Hospital Research Foundation ($13,636)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Dickson TC; Vickers JC
Year
2007
Unravelling the cellular pathology underlying neuronal degeneration in motor neuron disease (2007)$24,744
Funding
Motor Neurone Disease Research Institute of Australia Inc ($24,744)
Scheme
Grant-in-Aid Zo-ee MND Research
Administered By
University of Tasmania
Research Team
Vickers JC; King AE; Dickson TC; Chung RS; West AK; Chuah MI
Year
2007
Axon regeneration in the mature CNS (2007)$20,000
Funding
Royal Hobart Hospital Research Foundation ($20,000)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Vickers JC; Dickson TC
Year
2007
A New Experimental Model for Developing Therapeutic Strategies for Alzheimer's Disease (2006)$50,000
Funding
J.O. & J.R. Wicking Trust ($50,000)
Scheme
Grant-Medical & Scientific Research
Administered By
University of Tasmania
Research Team
Vickers JC; Dickson TC
Year
2006
The Role of the Cell Adhesion Molecule L1 in Foetal Alcohol Syndrome (2005)$8,000
Funding
University of Tasmania ($8,000)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Dickson TC
Year
2005
Alzheimer's Disease: 'Mass Effect' of B-amyloid Plaques Leads to Dementia (2005)$10,203
Funding
Royal Hobart Hospital Research Foundation ($10,203)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Dickson TC; Vickers JC
Year
2005
Nerve Cell Plasticity and the Neuropathology of Parkinson's Disease and Related Disorders (2005 - 2006)$123,242
Funding
Royal Hobart Hospital Research Foundation ($123,242)
Scheme
Fellowship-BG Thomas Post Doctoral Research
Administered By
University of Tasmania
Research Team
Dickson TC
Period
2005 - 2006
Spectramax M2 Multimode ELISA Plate Reader with Softmax Pro Software (2005)$33,019
Funding
National Health & Medical Research Council ($33,019)
Scheme
Grant-Equipment
Administered By
University of Tasmania
Research Team
Walters EH; Reid DW; Woods GM; Dickson TC
Year
2005
Grant Reference
264668
Focuses on the Role of Cell Adhesion Molecules in Alzheimer's Disease (2004 - 2006)$54,000
Funding
Masonic Centenary Medical Research Foundation ($54,000)
Scheme
Scholarship
Administered By
University of Tasmania
Research Team
Dickson TC
Period
2004 - 2006
The Cause of Neural Degeneration in Motor Neuron Disease (2004 - 2007)$56,000
Funding
Australian Rotary Health Research Fund ($56,000)
Scheme
Scholarship-Funding Partners
Administered By
University of Tasmania
Research Team
Vickers JC; Dickson TC
Period
2004 - 2007
Establishment of a Fluorescent Stereo-microscope Facility to Determine the Ability of Mature Neurons to Recover from Trauma (2003)$21,535
Funding
National Health & Medical Research Council ($21,535)
Scheme
Grant-Equipment
Administered By
University of Tasmania
Research Team
Chung RS; Dickson TC; West AK; Chuah MI; Vickers JC
Year
2003
The Role of the Cell Adhesion Molecule L1 in the Neuronal Response to Trauma (2003)$18,000
Funding
University of Tasmania ($18,000)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Dickson TC
Year
2003
The Relationship between Neuronal Trauma and The Cell Adhesion Molecule L1 (2003)$13,450
Funding
Royal Hobart Hospital Research Foundation ($13,450)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Dickson TC
Year
2003
In Vitro Models Relevant to Neuronal Trauma (2001 - 2004)$272,856
Funding
National Health & Medical Research Council ($272,856)
Scheme
Fellowship-CJ Martin
Administered By
University of Tasmania
Research Team
Dickson TC
Period
2001 - 2004
Grant Reference
159421
Microscope Facility for Live Cellular Imaging (2001)$35,000
Funding
National Health & Medical Research Council ($10,000)
Scheme
Grant-Equipment
Administered By
University of Tasmania
Research Team
Vickers JC; Dickson TC
Year
2001

Research Supervision

Current

5

Completed

15

Current

DegreeTitleCommenced
PhDSynaptic dysfunction: An early mechanism of TDP-43 pathogenesis in ALS?2014
PhDTDP-43 Mediated Synaptic Dysfunction in Neurodegenerative Disease2015
PhDMicrotubule Stabilisation: Promoting Adaptive Plasticity, Brain Healing and Functional Recovery Following Traumatic Brain Injury2015
PhDInhibitory Dysfunction in ALS: A systematic human pathology analysis2017
PhDPreclinical development of Neuropeptide Y for the treatment of Motor Neuron Disease2017

Completed

DegreeTitleCompleted
PhDTargeting Microtubules in the Distal Neuromuscular Circuitry to Improve Outcomes in Amyotrophic Lateral Sclerosis
Candidate: Jayden Andrew Clark
2017
PhDInterneuron Dysfunction in Amyotrophic Lateral Sclerosis
Candidate: Rosemary Maree Clark
2017
PhDInjury Induced Plasticity in Primary Neuronal Culture and the Mature Brain
Candidate: Mariana Del Valle Brizuela
2016
PhDThe Effect of Traumatic Brain Injury in Experimental Models of Alzheimers Disease
Candidate: Jessica Marie Collins
2016
PhDLab-on-a-Chip Platforms for Understanding Neuronal Cellular Interactions
Candidate: Yiing Chiing Yap
2015
PhDDistal Axon and Neuromuscular Junction Degeneration in Amyotrophic Lateral Sclerosis
Candidate: Katherine Adriana Southam
2014
PhDRole of Neurofilaments in Ageing and Neurodegenerative Disease
Candidate: Yao Liu
2013
PhDAxonal and Synaptic Pathology in Alzheimer's Disease
Candidate: Stanislaw Mitew
2013
PhDAlpha-synuclein in the Neurodegenerative Mechanisms of Parkinson's Disease and Dementia with Lewy Bodies
Candidate: Ruth Elizabeth Joy Musgrove
2012
PhDThe Response of the Mature Central Nervous System to Traumatic Brain Injury
Candidate: Catherine Anne Blizzard
2011
PhDUnravelling the Molecular and Cellular Mechanisms Contributing to Secondary Axonal Degeneration Following Traumatic Brain Injury
Candidate: Jerome Andrew Staal
2009
PhDPathological Changes Leading to Neuronal Degeneration in Alzheimer's Disease
Candidate: Adele Woodhouse
2008
PhDUnravelling the Cellular Pathology Leading to Neurodegeneration in Motor Neurone Disease
Candidate: Anna Elizabeth King
2008
PhDThe Role of Ezrin-Radixin-Moesin (ERM) Cytoskeletal Proteins in Neuronal Development and Post-Injury Responses of the Central Nervous System
Candidate: Matilda Ann Haas
2006
PhDMolecular and Cellular Events Underlying the Response of CNS Neurons to Structural Injury
Candidate: Jyoti Anabela Chuckowree
2006