Profiles

Alison Canty

UTAS Home Associate Professor Alison Canty

Alison Canty

Associate Professor
Wicking Dementia Research & Education Centre

Room 421b-01 (Level 4), Medical Science 1, Hobart CBD Campuses

+61 3 6226 4667 (phone)

Alison.Canty@utas.edu.au

Doctor Alison Canty is an Associate Professor in the Wicking Dementia Research and Education Centre in the Faculty of Health. Her research interests are in the field of neuroplasticity in health, ageing and disease with a particular interest in the cellular and molecular mechanisms of repair, regeneration and degeneration in the central nervous system. She is responsible for the coordination of the design and delivery of the fully online Bachelor of Dementia Care with emerging interest in the evaluation of curriculum design, review and scholarship of learning and teaching.

Career summary

Qualifications

  • PhD, University of Melbourne, Australia, 2004. The role of EphA4 in the topographical mapping of the corticospinal tract
  • Grad Cert UL&T, University of Tasmania, Australia, 2013
  • BSc (1st Class Hons), University of Tasmania, Australia, 1998. Cellular response to injury in the adult rat neocortex

Biography

Alison has a long-standing interest in the formation and plasticity of neural circuitry. This interest has seen her move around the globe, from Melbourne University for her PhD studies in axon guidance in the developing spinal cord, to the Karolinska institute in Stockholm, Sweden, to investigate the integration of interneurons into the juvenile cerebral cortex.

Following this, she had a 3 year career development fellowship at the Medical Research Council, part of Imperial College London, in the United Kingdom where she learnt the technique of in vivo imaging through a cranial window using 2-photon microscopy. This ground-breaking technique provides a novel tool to assess cortical circuitry rearrangements in real time.

Alison arrived in Tasmania for a lectureship/research position in the School of Medicine at the end of 2010. She is now a senior lecturer in the Wicking Dementia Research and Education Centre where her research interests have expanded to include the mechanisms of neurodegeneration in ageing and dementia.

Alison co-ordinates the Bachelor of Dementia Care, a fully online degree with a central role in the design and delivery of the curriculum to over 200 students. She has developing interests in the scholarship of learning and teaching.

Research Themes

Alison has a long-standing interest in the formation and plasticity of neural circuitry, aligning with the University's research theme of Better Health. This interest has seen her move around the globe, from Melbourne University for her PhD studies and to the Karolinska institute in Stockholm, Sweden and Imperial College of London to pursue her postdoctoral studies. Her research interests have gradually moved from investigating molecules involved in central nervous system development, to understanding circuitry rearrangements in the mature brain in both health and disease.

Alison arrived at the University of Tasmania in 2010 to continue her research in the live imaging of neural circuitry using the combination of transgenic technologies and live 2-photon imaging of brain circuitry. This ground-breaking imaging technique provides a novel tool to assess cortical circuitry rearrangements in real time. Her current interests include the elucidation of the mechanisms of axonal injury, degeneration and regeneration; the mechanisms of action transcranial magnetic stimulation and how it affects neural circuitry; the mechanisms of neuroplasticity in ageing and dementia.

Memberships

Professional practice

  • Australasian Neuroscience Society

Administrative expertise

Alison has been instrumental in the coordination - design, development and delivery - of the suite of Dementia Care Awards – the Diploma, Associate Degree and Bachelor of Dementia Care. This involves engaging with a wide variety of stakeholders, internal and external to the University, and the mananagement of a growing team of academic staff.

Teaching

Dementia, Bioscience, Neuroscience, Nervous System, Anatomy, Physiology, Pathology, Neuropathology.

Teaching expertise

Alison's expertise is in the teaching of undergraduate neuroscience, human anatomy, physiology and pathology. She has taught for a number of years to students in the Bachelors of Nursing, Paramedic Practice and Medical Research. She has also developed and delivered completely online units of study in the field of neuroscience. She has supervised postgraduate research students.

Teaching responsibility

Alison is responsible for oversight and management of all units within the Diploma, Associate Degree and Bachelor of Dementia Care.

Unit coordinator:

Regular contribution to the teaching of:

View more on AssocProf Alison Canty in WARP

Expertise

Alison has extensive skills in live imaging of the brain circuitry using 2 photon microscopy to directly visualise living circuitry in a range of models. This extends to gross structural rearrangements and at the synaptic level of individual connections between brain cells. She employs a range of general techniques in her research including molecular biology, immunohistochemistry, animal behaviour paradigms, sophisticated image analysis and advanced microscopy techniques including light, electron, fluorescence, confocal and multi-photon microscopy.

Collaboration

Alison actively collaborates with a range of researchers in the Wicking Dementia Research Education Centre including Prof James Vickers, Dr Anna King and Dr Matthew Kirkcaldie. Regarding her interest in the mechanisms of repetitive magnetic stimulation, Alison currently collaborates with Associate Professor Jennifer Rodger at the University of Western Australia, Dr Mark Hinder and Professor Jeff Summers in the Discipline of Psychology, University of Tasmania and (JS also at Liverpool John Moors University).  Alison maintains active collaborations in the field of axonal and synaptic dynamics with Dr Vincenzo De Paola (Imperial College London), Dr Federico Grillo (University College London), Dr Lieven Huang (Monash University and Dr Johanna Jackson (Eli Lilly Pharmaceuticals, United Kingdom).

Current projects

Current projects include:

  1. Mechanisms of neuroplasticity induced by intermittent theta burst stimulation in a rodent model of motor learning and in vivo visualisation of motor circuitry in transgenic mice.
  2. Mechanisms of axonal and dendritic degeneration in laser-mediated lesions of the somatosensory cortex in Thy1-GFP mice.
  3. Investigation of neural circuitry rearrangements in animal models of ageing and dementia using a suite of behavioural paradigms and in vivo imaging.

Fields of Research

  • Central Nervous System (110903)
  • Cellular Nervous System (110902)
  • Neurosciences (110999)
  • Health Promotion (111712)
  • Medicine, Nursing and Health Curriculum and Pedagogy (130209)
  • Peripheral Nervous System (110905)
  • Neurology and Neuromuscular Diseases (110904)
  • Autonomic Nervous System (110901)
  • Curriculum and Pedagogy Theory and Development (130202)
  • Signal Transduction (060111)
  • Aboriginal and Torres Strait Islander Health (111701)
  • Neurogenetics (060410)

Research Objectives

  • Nervous System and Disorders (920111)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Health Education and Promotion (920205)
  • Public Health (excl. Specific Population Health) (920499)
  • Assessment and Evaluation of Curriculum (930301)
  • Expanding Knowledge in the Information and Computing Sciences (970108)
  • Cardiovascular System and Diseases (920103)
  • Learner and Learning Processes (930102)
  • Health Related to Ageing (920502)
  • Health (929999)
  • Expanding Knowledge in the Biological Sciences (970106)
  • Evaluation of Health Outcomes (920204)

Publications

Alison has maintained an active interest in publishing her research findings in a range of high impact scientific journals including Nature Communications, PNAS, Science and Current Opinion in Neurobiology. She also contributes review papers and book chapters in the field of neuroplasticity. She reviews grant applications for the NHMRC the Alzheimer's Association Australia and is a reviewer for a range of journals including Advances in Optics and Photonics and is a guest editor for a special edition of the Journal of Chemical Neuroanatomy.

Total publications

53

Highlighted publications

(4 outputs)
YearTypeCitationAltmetrics
2013Journal ArticleCanty A, Huang L, Jackson JS, Little GE, Knott G, et al., 'In-vivo single neuron axotomy triggers axon regeneration to restore synaptic density in specific cortical circuits', Nature Communications , 4 Article 2038. ISSN 2041-1723 (2013) [Refereed Article]

DOI: 10.1038/ncomms3038 [eCite] [Details]

Citations: Scopus - 27Web of Science - 40

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2013Journal ArticleCanty A, Teles-Grilo Ruivo LM, Nesarajah C, Song S, Jackson JS, et al., 'Synaptic elimination and protection after minimal injury depend on cell type and their prelesion structural dynamics in the adult cerebral cortex', Journal of Neuroscience, 33, (25) pp. 10374-83. ISSN 0270-6474 (2013) [Refereed Article]

DOI: 10.1523/JNEUROSCI.0254-13.2013. [eCite] [Details]

Citations: Scopus - 9Web of Science - 10

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2007Journal ArticleBerghuis P, Rajnicek AM, Morozov YM, Ross RA, Mulder J, et al., 'Hardwiring the bain: Endocannabinoids shape neuronal connectivity', Science, 316, (5828) pp. 1212-1216. ISSN 0036-8075 (2007) [Refereed Article]

DOI: 10.1126/science.1137406 [eCite] [Details]

Citations: Scopus - 243Web of Science - 230

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2006Journal ArticleCanty A, Greferath U, Turnley AM, Murphy M, 'Eph tyrosine kinase receptor EphA4 is required for the topographic mapping of the corticospical tract', National Academy of Sciences of The United States of America. Proceedings, 103, (42) pp. 15629-15634. ISSN 0027-8424 (2006) [Refereed Article]

DOI: 10.1073/pnas.0607350103 [eCite] [Details]

Citations: Scopus - 17Web of Science - 17

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Journal Article

(21 outputs)
YearCitationAltmetrics
2016Puri R, Hinder MR, Canty AJ, Summers JJ, 'Facilitatory non-invasive brain stimulation in older adults: the effect of stimulation type and duration on the induction of motor cortex plasticity', Experimental brain research, 234 pp. 3411-3423. ISSN 0014-4819 (2016) [Refereed Article]

DOI: 10.1007/s00221-016-4740-3 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Puri R; Hinder MR; Summers JJ

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2016Vickers J, Mitew S, Woodhouse A, Fernandez-Martos CM, Kirkcaldie MTK, et al., 'Defining the earliest pathological changes of Alzheimer's disease', Current Alzheimer research, 13 pp. 281-287. ISSN 1567-2050 (2016) [Refereed Article]

DOI: 10.2174/1567205013666151218150322 [eCite] [Details]

Citations: Web of Science - 3

Co-authors: Vickers J; Mitew S; Woodhouse A; Fernandez-Martos CM; Kirkcaldie MTK; McCormack GH; King AE

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2016Tang AD, Lowe AS, Garrett AR, Woodward R, Bennett W, et al., 'Construction and Evaluation of Rodent-Specific rTMS Coils', Frontiers in Neural Circuits, 10 Article 47. ISSN 1662-5110 (2016) [Refereed Article]

DOI: 10.3389/fncir.2016.00047 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Bennett W; Garry MI; Hinder MR; Summers JJ

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2015Goldberg LR, Canty A, 'Quality assurance in online learning: The contribution of computational linguistics analysis to criterion referenced assessment', eLearning Papers, (40) pp. 1-5. ISSN 1887-1542 (2015) [Refereed Article]

[eCite] [Details]

Co-authors: Goldberg LR

2015Jackson J, Canty AJ, Huang L, De Paola V, 'Laser-mediated microlesions in mouse neocortex to investigate neuronal degeneration and regeneration', Current Protocols in Neuroscience, 73 Article 2.24. ISSN 1934-8584 (2015) [Refereed Article]

DOI: 10.1002/0471142301.ns0224s73 [eCite] [Details]

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2014Hinder MR, Goss EL, Fujiyama H, Canty AJ, Garry MI, et al., 'Inter- and intra-individual variability following intermittent theta burst stimulation: implications for rehabilitation and recovery', Brain Stimulation, 7, (3) pp. 365-371. ISSN 1935-861X (2014) [Refereed Article]

DOI: 10.1016/j.brs.2014.01.004 [eCite] [Details]

Citations: Scopus - 35Web of Science - 35

Co-authors: Hinder MR; Goss EL; Fujiyama H; Garry MI; Summers JJ

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2013Canty A, Huang L, Jackson JS, Little GE, Knott G, et al., 'In-vivo single neuron axotomy triggers axon regeneration to restore synaptic density in specific cortical circuits', Nature Communications , 4 Article 2038. ISSN 2041-1723 (2013) [Refereed Article]

DOI: 10.1038/ncomms3038 [eCite] [Details]

Citations: Scopus - 27Web of Science - 40

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2013Canty A, Teles-Grilo Ruivo LM, Nesarajah C, Song S, Jackson JS, et al., 'Synaptic elimination and protection after minimal injury depend on cell type and their prelesion structural dynamics in the adult cerebral cortex', Journal of Neuroscience, 33, (25) pp. 10374-83. ISSN 0270-6474 (2013) [Refereed Article]

DOI: 10.1523/JNEUROSCI.0254-13.2013. [eCite] [Details]

Citations: Scopus - 9Web of Science - 10

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2012Liu Yao, Staal JA, Canty AJ, Kirkcaldie MTK, King AE, et al., 'Cytoskeletal changes during development and aging in the cortex of neurofilament light protein knockout mice', The Journal of Comparative Neurology, 521, (8) pp. 1817-1827. ISSN 0021-9967 (2012) [Refereed Article]

DOI: 10.1002/cne.23261 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Liu Yao; Staal JA; Kirkcaldie MTK; King AE; Bibari O; Mitew ST; Dickson TC; Vickers JC

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2011Brown KM, Barrionuevo G, Canty AJ, De Paola V, Hirsch JA, et al., 'The DIADEM Data Sets: Representative Light Microscopy Images of Neuronal Morphology to Advance Automation of Digital Reconstructions', Neuroinformatics, 9, (2-3) pp. 143-157. ISSN 1539-2791 (2011) [Refereed Article]

DOI: 10.1007/s12021-010-9095-5 [eCite] [Details]

Citations: Scopus - 58Web of Science - 47

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2011Canty AJ, De Paola V, 'Axonal Reconstructions Going Live', Neuroinformatics, 9, (2-3) pp. 129-131. ISSN 1539-2791 (2011) [Refereed Article]

DOI: 10.1007/s12021-011-9112-3 [eCite] [Details]

Citations: Scopus - 1Web of Science - 4

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2009Canty A, Dietze J, Harvey M, Enomoto H, Milbrandt J, et al., 'Regionalized loss of Parvalbumin interneurons in the cerebral cortex of mice lacking RET-independent GFRα 1', Journal of Neuroscience, 29, (34) pp. 10695-10705. ISSN 0270-6474 (2009) [Refereed Article]

DOI: 10.1523/JNEUROSCI.2658-09.2009 [eCite] [Details]

Citations: Scopus - 30Web of Science - 32

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2008Canty A, Murphy M, 'Molecular mechanisms of axon guidance in the developing corticospinal tract', Progress in Neurobiology, 85, (2) pp. 214-235. ISSN 0301-0082 (2008) [Refereed Article]

DOI: 10.1016/j.pneurobio.2008.02.001 [eCite] [Details]

Citations: Scopus - 48Web of Science - 43

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2007Berghuis P, Rajnicek AM, Morozov YM, Ross RA, Mulder J, et al., 'Hardwiring the bain: Endocannabinoids shape neuronal connectivity', Science, 316, (5828) pp. 1212-1216. ISSN 0036-8075 (2007) [Refereed Article]

DOI: 10.1126/science.1137406 [eCite] [Details]

Citations: Scopus - 243Web of Science - 230

Tweet

2006Canty A, Greferath U, Turnley AM, Murphy M, 'Eph tyrosine kinase receptor EphA4 is required for the topographic mapping of the corticospical tract', National Academy of Sciences of The United States of America. Proceedings, 103, (42) pp. 15629-15634. ISSN 0027-8424 (2006) [Refereed Article]

DOI: 10.1073/pnas.0607350103 [eCite] [Details]

Citations: Scopus - 17Web of Science - 17

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2003Canty A, 'Will Superman ever fly again?', Traffic: An Interdisciplinary Postgraduate Journal, 2 pp. 121-138. ISSN 1447-2538 (2003) [Refereed Article]

[eCite] [Details]

2002Allen JP, Canty A, Schultz S, Humphrey PP, Emson PC, et al., 'Identification of cells expressing somatostatin receptor 2 in the gastrointestinal tract of Sstr2 knockout/lacZ knockin mice', The Journal of Comparative Neurology, 454, (3) pp. 329-340. ISSN 0021-9967 (2002) [Refereed Article]

DOI: 10.1002/cne.10466 [eCite] [Details]

Citations: Scopus - 49Web of Science - 45

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2002Greferath U, Canty A, Messenger J, Murphy M, 'Developmental expression of EphA4-tyrosine kinase receptor in the mouse brain and spinal cord', Mechanisms of Development, 119, (Supplement 1) pp. S231-238. ISSN 0925-4773 (2002) [Refereed Article]

DOI: 10.1016/S0925-4773(03)00122-9 [eCite] [Details]

Citations: Scopus - 22Web of Science - 18

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2001King CE, Canty A, Vickers JC, 'Alteration in neurofilaments associated with reactive brain changes and axonal sprouting following acute physical injury to the rat neocortex', Neuropathology and Applied Neurobiology, 27, (2) pp. 115-126. ISSN 0305-1846 (2001) [Refereed Article]

DOI: 10.1046/j.1365-2990.2001.00317.x [eCite] [Details]

Citations: Scopus - 49Web of Science - 48

Co-authors: King CE; Vickers JC

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2001Young HM, Hearn CJ, Farlie PG, Canty A, Thomas PQ, et al., 'GDNF is a chemoattractant for enteric neural cells', Developmental Biology: An International Journal, 229, (2) pp. 503-516. ISSN 0012-1606 (2001) [Refereed Article]

DOI: 10.1006/dbio.2000.0100 [eCite] [Details]

Citations: Scopus - 211Web of Science - 192

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1999Young HM, Ciampoli D, Hsuan J, Canty A, 'Expression of Ret-, p75(NTR)-, Phox2a-, Phox2b-, and tyrosine hydroxylase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut', Developmental Dynamics, 216, (2) pp. 137-152. ISSN 1058-8388 (1999) [Refereed Article]

DOI: 10.1002/(SICI)1097-0177(199910)216:2<137::AID-DVDY5>3.0.CO;2-6 [eCite] [Details]

Citations: Web of Science - 138

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Chapter in Book

(1 outputs)
YearCitationAltmetrics
2016Grillo F, Canty AJ, Bloomfield P, De Paola V, 'In Vivo Visualization of Single Axons and Synaptic Remodeling in Normal and Pathological Conditions', Axons and Brain Architecture, Academic Press, KS Rockland (ed), United States, pp. 223-244. ISBN 978-0-12-801393-9 (2016) [Research Book Chapter]

DOI: 10.1016/B978-0-12-801393-9.00011-6 [eCite] [Details]

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Conference Publication

(31 outputs)
YearCitationAltmetrics
2017Goldberg LR, Westbury J, Canty A, McInerney F, Vickers JC, et al., 'The Bachelor of Dementia Care: Education as an essential intervention in building dementia literacy', 32nd International Conference of Alzheimer's Disease International, 26-29 April 2017, Kyoto, Japan (2017) [Conference Extract]

[eCite] [Details]

Co-authors: Goldberg LR; Westbury J; McInerney F; Vickers JC; Robinson AL

2016Goldberg LM, Carr AR, Canty A, Klekociuk SZ, Ward D, et al., 'Making Neuroscience Important and Relevant: Online Learning in an Innovative Bachelor of Dementia Care Program', E-Learning, E-Education, and Online Training, 16-18, 2015, Novedrate, Italy, pp. 84-91. ISBN 978-3-319-28882-6 (2016) [Refereed Conference Paper]

DOI: 10.1007/978-3-319-28883-3 [eCite] [Details]

Co-authors: Goldberg LM; Carr AR; Klekociuk SZ; Ward D; Landowski LM; King Carolyn; McInerney F; Vickers JC

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2015Canty A, Goldberg LR, Ziebell JM, Ceperkovic H, 'Meeting the challenge of designing and delivering an entry level unit of study to engage and inspire adult learners in online neuroscience education in a Bachelor of Dementia Care', ICERI2015 Proceedings, 18-20 November, 2015, Seville, Spain, pp. 3941-3951. ISBN 978-84-608-2657-6 (2015) [Non Refereed Conference Paper]

[eCite] [Details]

Co-authors: Goldberg LR; Ziebell JM; Ceperkovic H

2015Tang G, Garrett A, Woodward R, Bennett WR, Hadrill CE, et al., 'Construction and evaluation of rodent-specific TMS coils', 1st International Brain Stimulation Conference, 2-4 March, 2015, Singapore (2015) [Conference Extract]

[eCite] [Details]

Co-authors: Bennett WR; Hadrill CE; Garry MI; Hinder MR; Summers JJ

2015Canty A, 'Chair for session: Experiences in Health Sciences Education', ICERI2015: 8th International Conference of Education, Research and Innovation, 16-18 November, 2015, Seville, Spain (2015) [Chair National Conference]

[eCite] [Details]

2015Tang A, Bennett WR, Garry MI, Hinder MR, Summers JJ, et al., 'Investigating the mechanisms of repetitive transcranial magnetic stimulation using motor learning paradigms and in vivo 2 photon imaging', 1st International Brain Stimulation Conference, 2-4 March, 2015, Singapore (2015) [Conference Extract]

[eCite] [Details]

Co-authors: Bennett WR; Garry MI; Hinder MR; Summers JJ

2014Canty A, Burke KF, Carr AR, Ceperkovic H, Elliott Kate-Ellen, et al., 'Online Learning and Aspirations in the Bachelor of Dementia Care degree', Aspirations Matter 2014, 5th December, 2014, Launceston, Tasmania (2014) [Conference Extract]

[eCite] [Details]

Co-authors: Burke KF; Carr AR; Ceperkovic H; Elliott Kate-Ellen; Goldberg LR; Grace A; Jestrimski JW; Kleinig KL; Landowski LM; Minstrell ML; Price AD

2013Kelder J, Canty A, Carr A, Skalicky J, Walls J, et al., 'A learning place where a high-risk student cohort can succeed: curriculum, assessment and teacher recruitment', Research and Development in Higher Education: The place of learning and teaching Volume 36, 1-4 July 2013, Auckland, New Zealand, pp. 253-265. ISBN 0 908557 93 0 (2013) [Refereed Conference Paper]

[eCite] [Details]

Co-authors: Kelder J; Carr A; Skalicky J; Walls J; Robinson A; Vickers J

2012Canty A, Huang L, Jackson J, De Paola V, 'Observing axonal degeneration following laser mediated micro-lesion in the living brain', Australian Neuroscience Society Annual Meeting, Brisbane (2012) [Conference Extract]

[eCite] [Details]

2012Canty A, Huang L, Jackson J, Ruivo L, Little G, et al., 'In vivo 2-photon imaging of axonal regeneration and synaptic remodeling after laser-mediated micro lesions in the adult brain', Society for Neuroscience Annual Meeting, New Orleans (2012) [Conference Extract]

[eCite] [Details]

2012Canty A, Andrews SM, Carew TP, Kelder JC, King CE, et al., 'Associate Degree in Dementia Care: Sustaining a course and maintaining the students', Teaching Matters, 4 Dec, Launceston (2012) [Conference Extract]

[eCite] [Details]

Co-authors: Andrews SM; Carew TP; Kelder JC; King CE; McInerney F; Robinson AL; Skalicky JL; Vickers JC; Walls JT

2011Canty A, 'Axonal pathology in vivo', Wicking Dementia Research and Education, 22-24 June, Hobart (2011) [Conference Extract]

[eCite] [Details]

2011Canty A, 'In vivo imaging of axonal degeneration', 2nd Annual Australian Neurotrauma meeting, Hobart (2011) [Conference Extract]

[eCite] [Details]

2010Canty A, 'Through the looking glass - observations of lesioned cortical axons using in vivo 2-photon microscopy', National Neural Injury and Regeneration Symposium, Hobart (2010) [Conference Extract]

[eCite] [Details]

2010Canty A, 'In vivo 2-photon imaging of laser-mediated microlesions in the adult brain', International 2nd Imperial College Imaging Event, London (2010) [Conference Extract]

[eCite] [Details]

2010Canty A, Huang L, De Paola V, 'In vivo 2-photon imaging of laser-mediated microlesions in the adult brain', Australian Neuroscience Society Annual Meeting, Sydney (2010) [Conference Extract]

[eCite] [Details]

2010Canty A, Huang LH, De Paola V, 'In vivo 2-photon imaging of laser-mediated microlesions in the adult brain', International 7th FENS Forum of European Neuroscience, Amsterdam, The Netherlands (2010) [Conference Extract]

[eCite] [Details]

2009Canty A, 'Imaging synaptic plasticity in the adult living brain', International 1st Imperial College Imaging Event, London (2009) [Conference Extract]

[eCite] [Details]

2009Canty A, De Paola V, 'In vivo 2-photon imaging of laser-mediated microlesions in the adult brain', International British Neuroscience Association 20th National Meeting, Liverpool, UK (2009) [Conference Extract]

[eCite] [Details]

2007Canty A, Dietze J, Harvey M, Roland P, Ibanez F, 'Role of the GDNF-GFRa1 signalling system in the development and function of cortical parvalbumin interneurons', International Gordon Research Conference: Neurotrophic Factors, Rhode Island, USA (2007) [Conference Extract]

[eCite] [Details]

2007Canty A, Harvey M, Dietze J, Ibanez C, 'GDNF and GFRa1 contribute to sub populations of GABAergic interneurons in the adult cortex', International NeuroNE EU Consortium Annual Meeting, Barcelona (2007) [Conference Extract]

[eCite] [Details]

2007Canty A, Harvey M, Roland P, Dietze J, Ibanez CF, 'Role of the GDNF-GFRa1 signalling system in the development and function of cortical parvalbumin interneurons', International Society for Neuroscience Annual Meeting, San Diego (2007) [Conference Extract]

[eCite] [Details]

2006Canty A, Harvey M, Ibanez C, 'GFRa1 and GDNF - how do they contribute to the network of cortical interneurons?', International Extracellular mediators and intracellular pathways determining axon growth and cell survival/death, Como, Italy (2006) [Conference Extract]

[eCite] [Details]

2006Canty A, Ibanez C, 'GFR-alpha1 signalling in the generation of cortical interneurons', International Axon Degeneration and Regeneration Workshop, Cambirdge, UK (2006) [Conference Extract]

[eCite] [Details]

2006Canty A, Ibanez C, 'GFR-alpha1 signalling in the MGE', International NeuroNE EU Consortium Annual Meeting, London (2006) [Conference Extract]

[eCite] [Details]

2005Canty A, Ibanez C, 'GFR-alpha1 signalling in the generation of cortical interneurons', International EU GDNF Consortium Meeting, London (2005) [Conference Extract]

[eCite] [Details]

2004Canty A, Greferath U, Murphy M, 'EphA4 in the developing corticospinal tract - what's going on?', National Australian Neuroscience Society Annual Meeting, Melbourne (2004) [Conference Extract]

[eCite] [Details]

2003Canty A, Greferath U, Murphy M, 'The role of the EphA4 receptor in the developing corticospinal tract', International Keystone Symposium: Axonal Connections-Molecular Cues for Development and Regeneration, New Mexico, USA (2003) [Conference Extract]

[eCite] [Details]

2002Canty A, Greferath U, Murphy M, 'The function of AphA4 in the developing corticospinal tract', National 3rd Asia Pacific Symposium on Neural Regeneration, Perth, WA (2002) [Conference Extract]

[eCite] [Details]

1999Canty A, King CE, Vickers JC, 'Relationship of the response of non-neuronal cells to the axonal changes that follow physical injury to the rodent neocortex', National Australian Neuroscience Society Annual Meeting, Hobart (1999) [Conference Extract]

[eCite] [Details]

Co-authors: King CE; Vickers JC

1999Canty A, King CE, Vickers JC, 'The neuronal response to physical injury', National Australian Society of Medical Research Annual Meeting, Hobart (1999) [Conference Extract]

[eCite] [Details]

Co-authors: King CE; Vickers JC

Grants & Funding

Alison currently holds two NHMRC project grants - The mechanisms of repetitive trans-cranial magnetic stimulation: a translational approach (CIB, #S0020364) and Axon degeneration and axon protection in CNS disease and injury (CIC, # K0022166). She was also the recipient of a University of Tasmania Research Enhancement Scheme grant in 2014, and a range of conference travel grants.

Funding Summary

Number of grants

6

Total funding

$1,126,040

Projects

How do microglia-synapse dynamics change with Alzheimer's disease? (2017)$50,000
Description
This project explores the emerging role of microglia in facilitating changes to neuronal connections, synaptic plasticity or the ability of the brain to remodel throughout the lifespan in response to a changing environment. Using state of the art imaging techniques, this project will explore microglia-synapse interactions in real time, to elucidate the role microglia play in synaptic plasticty in Alzheimer's disease and throughout ageing.
Funding
Alzheimer's Australia Dementia Research Foundation ($50,000)
Scheme
Grant-Dementia Grants Program
Administered By
University of Tasmania
Research Team
Ziebell JM; Canty A; King AE
Year
2017
Axon degeneration and axon protection in CNS disease and injury (2015 - 2017)$377,077
Funding
National Health & Medical Research Council ($377,077)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
King AE; Vickers JC; Canty A
Period
2015 - 2017
Grant Reference
1085221
A Translational Approach to Understanding the Effects of Brain Stimulation (2014)$34,000
Description
Brain function is underpinned by electrical activity that is vital for communication between cells, and for establishing and maintaining normal brain structure and function. Modulation of electrical activity by repetitive trans-cranial magnetic stimulation (rTMS) is becoming widely recognised as a clinically applicable non-invasive intervention to improve and repair neural function in humans.
Funding
University of Tasmania ($34,000)
Scheme
Grant-Research Enhancement (REGS)
Administered By
University of Tasmania
Research Team
Canty A; Hinder MR
Year
2014
US Society for Neuroscience Meeting, USA November 2014 (2014)$2,500
Description
Conference presentation and attendance to the US Society for Neuroscience Meeting.
Funding
University of Tasmania ($2,500)
Scheme
Grant-Conference Support Scheme
Administered By
University of Tasmania
Research Team
Canty A
Year
2014
Axon protection in Alzheimer's disease (2014)$59,097
Description
Alzheimers disease (AD) affects approximately 11% of the population over 65 years and up to 50% of individuals over 85 years and is now the 3rd major cause of death in Australia. In the absence of effective therapeutic intervention it is imperative that we renew our research efforts along novel and innovative lines to prevent, palliate and/ or reduce this condition. One of the key features of AD is the degeneration of the long nerve processes or axons. These are susceptible to damage and this can result in nervous system disconnection and failure even in the absence of cell loss. My research focuses on understanding why axons degenerate in neurodegenerative disease with the aim of finding effective therapeutic agents to prevent this loss. Due to our lack of mechanistic insight into axon degeneration mechanisms, there are currently no therapeutic drugs that target axon degeneration, and this could be one reason to account for the failure of many therapeutic agents that provide only neuronal protection. Therefore axon protection strategies may offer promise in preventing or delaying the ongoing clinical symptoms of the disease. To address this important issue, I have developed a novel cell culture technique that uses microfluidic technology to separate neuronal axons from the soma. This allows us to probe the cellular mechanisms of axon degeneration in conditions related to AD. Using these novel in vitro techniques I have begun to unravel some of these mechanisms and identify some potential points of intervention. Specifically, I have examined axon degeneration mechanisms following excitotoxicity, which results from overstimulation of neurons. Excitotoxicity is one of the key causes of nerve cell degeneration in AD. My work has shown that excitotoxicity causes axons to degenerate and that destabilization of microtubule proteins is an early event in this degeneration. Importantly, stabilizing microtubules with drugs such as taxol and epothilone D prevents axon degeneration following excitotoxicity in our cell culture model. Taxol and epothilone D are both agents that are currently approved for use in the treatment of cancer. The next step is to test whether these agents can block axon degeneration in animal models. In order to do this I will use two models. Firstly I will use an in vivo model of axon degeneration induced by excitotoxicity. This will be used to directly confirm that microtubule stabilization with epothilone D can protect axons from degeneration following excitotoxicity in vivo. Secondly I will use a mouse model of AD which develops axon pathology and for which excitotoic mechanisms are implicated. This AD will be treated with Epothilone D and pathology examined as well as cognitive function. This project will provide preliminary data to pave the way to expanding the project by obtaining significant funding from national research funding schemes such as NHMRC.
Funding
Equity Trustees Limited ($59,097)
Scheme
Grant
Administered By
University of Tasmania
Research Team
King AE; Canty A; Fernandez-Martos CM
Year
2014
The mechanisms of repetitive transcranial magnetic stimulation: A translational approach (2013 - 2015)$603,366
Funding
National Health & Medical Research Council ($603,366)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Summers JJ; Canty A; Hinder MR; Rodger Jennifer; Garry MI
Period
2013 - 2015
Grant Reference
1050261

Research Supervision

Alison has supervised a number of undergraduate research students at the University of Melbourne, Karolinska Institute, Imperial College and the University of Tasmania. She has co-supervised two Masters students and is currently supervising one PhD Student. Alison is currently available to take on supervision of Higher Degree Research Students in the Faculty of Health.

Current

1

Completed

1

Current

DegreeTitleCommenced
PhDCharacterisation of Axonal Response to Passive and Environmentally Induced Neuroplasticty in Alzheimer's Disease2016

Completed

DegreeTitleCompleted
PhDThe Effect of Traumatic Brain Injury in Experimental Models of Alzheimers Disease
Candidate: Jessica Marie Collins
2016