Profiles

Anthony Cook

UTAS Home Dr Anthony Cook

Anthony Cook

Senior Lecturer
Wicking Dementia Research & Education Centre

Room 417a, Medical Science 1 (MS1), Hobart CBD Campuses

+61 3 6226 6964 (phone)

Anthony.Cook@utas.edu.au

Dr Cook is a Senior Lecturer within the Wicking Dementia Research and Education Centre. He research interests lie in developing and utilising human cell-based models of neurodegenerative diseases to uncover molecular pathways that contribute to disease onset and progression.

Career summary

Qualifications

  • PhD, University of Queensland, Australia. 2004 Thesis: Models of Human Neural Crest Cell Differentiation in Vitro
  • Graduate Certificate in University Learning and Teaching, University of Tasmania, Australia. 2015
  • BSc Hons (1st Class), University of Queensland, Australia 2000 Thesis: Homeobox Gene Expression in Merkel Cell Carcinoma
  • BSc, University of Queensland, Australia. 1999

Biography

Dr Cook completed his BSc and BSc (Hons, First Class) degrees in 1999 and 2000 respectively, at The University of Queensland (UQ), majoring in biochemistry for each. He subsequently undertook research studies towards the degree of Doctor of Philosophy in Assoc Prof Rick Sturm's laboratory within the Institute for Molecular Bioscience at UQ, and was awarded a PhD in the Field of Molecular Biology/Biochemistry in 2004. His thesis was awarded the Dean's commendation for Outstanding Research Higher Degree Theses 2004.

Since completion of his PhD, Dr Cook has been employed as a post-doctoral scientist at UQ, Griffith University (Queensland, Australia) and the University of Tasmania (UTas).  From 2010 - June 2015, he was the employed as a Lecturer in Human Biological Science within the School of Health Sciences, and from July 2015 as a Senior Lecturer within the Wicking Dementia Research and Education Centre at The University of Tasmania, where he developed an extensive teaching portfolio that includes cell biology, biochemistry/ molecular biology, and molecular genetics at all undergraduate levels.

Research Themes

Dr Cook's research aligns to the University's Better Health research theme. His research interests include development of human cell-based models of disease that facilitate studying the underlying biology of disease onset or progression. These interests stem from solid doctoral and post-doctoral training in the development of human cell-based models to study the molecular and cellular biology of genetic traits and disease mechanisms (natural variation in pigmentation, and Parkinson's disease [PD], respectively). Since joining the University of Tasmania, Dr Cook has focused his research on human stem cell-based models of two age-related chronic neurodegenerative diseases: dementia, and the blinding eye disease glaucoma. By directly studying the biology of human cells from people with disease, Dr Cook's research will help to identify new possibilities for prevention or treatment, and which may ultimately translate to improved healthcare outcomes.

Memberships

Professional practice

  • Member, Association for Research in Vision and Ophthalmology
  • Member, Australian Society for Stem Cell Research
  • Member, Australian Society for Medical Research
  • Member, Molecular and Experimental Pathology Society of Australia

Committee associations

  • Member, Institutional Biosafety Committee, University of Tasmania (2011 - present)
  • Co-ordinator, Undergraduate Research Opportunity Program (UROP), School of Health Sciences, University of Tasmania (2013-2014)

Other

  • Convenor, Medical Research Week Gala Dinner, Australian Society for Medical Research (Tasmanian Branch), for 2011, 2012 and 2014.

Teaching

Cell biology, biochemistry, molecular biology, molecular genetics, dementia, neurobiology, neuroscience

Teaching expertise

Dr Cook has a teaching portfolio that includes design, delivery and assessment within Units encompassing cell biology, biochemistry and molecular biology, and molecular genetics at all undergraduate levels, and in flexible delivery modes (face-to-face and fully online). Furthermore, he has taught these topics to students undertaking health-related degrees in fields other than with biochemistry/molecular biology majors, including biomedical science (pathology), exercise science, and dementia studies. He is interested in pedagogical approaches to teaching and learning that are inquiry driven and which teach science as science is practiced.

Teaching responsibility

Dr Cook acts as co-ordinator for several Units within the Bachelor of Dementia Care, including Advanced Topics in Neurobiology of Dementia (CAD302).

Research Appointments

Dr Cook was a participant in the Theo Murphy High Flyers Think Tank 2015 on the topic the Stem Cell Revolution – lessons and imperatives for Australia, an event organised by the Australian Academy of Science.

View more on Dr Tony Cook in WARP

Expertise

  • Modelling of human disease and phenotypic traits using donor-specific cell lines
  • Mammalian cell culture techniques (including establishing primary cell cultures, and in maintenance and differentiation of stem cell cultures)
  • Cell and molecular biology  techniques

Collaboration

Dr Cook has active collaborations with other scientists within the Wicking Dementia Research and Education Centre, with the Faculty of Health at the University of Tasmania, with Tasmanian-based ophthalmologists, and nationally with stem cell researchers.

Current projects

  1. Stem cell derived models of age-related degenerative diseases:
    1. Dementia In this project, we are using donor-specific cells derived from participants from the Tasmanian Healthy Brain Project.  Induced pluripotent stem cells (iPSCs) corresponding to each donor are matured into neurons in the laboratory for molecular charaterisation and functional assays.  This work is collaboration involving a large number of researchers within the wicking Dementia Research and Education Centre, and other local and national scientists.
    2. Glaucoma In this project, we are investigating the cellular and molecular changes that occur within various cell types within the eye, including retinal ganglion cells, astrocytes, and trabecular meshwork cells, that contribute to the blinding disease glaucoma. This work is being done in collaboration with Assoc. Prof. Alex Hewitt (School of Medicine, UTas / Menzies) and Dr Alice Pebay (Centre for Eye Research Australia).
  2. Molecular analysis of clinical samples obtained from glaucoma patients during surgical treatment for advanced disease. This involves collection of aqueous humor for cytokine and growth factor profiling. This work is being done in collaboration with Dr Tze'Yo Toh, a glaucoma and cataract specialist at the Launceston Eye Institute.

Fields of Research

  • Cancer Genetics (111203)
  • Cell Development, Proliferation and Death (060103)
  • Optometry and Ophthalmology (111399)
  • Cellular Nervous System (110902)
  • Cell Metabolism (060104)
  • Ophthalmology (111301)
  • Epigenetics (incl. Genome Methylation and Epigenomics) (060404)
  • Signal Transduction (060111)
  • Biochemistry and Cell Biology (060199)
  • Medical Biochemistry and Metabolomics (110199)
  • Animal Physiology - Systems (060603)
  • Molecular Medicine (030405)
  • Neurosciences (110999)
  • Regenerative Medicine (incl. Stem Cells and Tissue Engineering) (100404)
  • Education Assessment and Evaluation (130303)
  • Central Nervous System (110903)
  • Cancer Cell Biology (111201)
  • Nutrition and Dietetics (111199)
  • Vision Science (111303)
  • Neurology and Neuromuscular Diseases (110904)
  • Nutritional Physiology (111103)
  • Genetic Immunology (060406)
  • Nanotoxicology, Health and Safety (100713)
  • Science, Technology and Engineering Curriculum and Pedagogy (130212)
  • Gastroenterology and Hepatology (110307)
  • Sensory Systems (110906)
  • Cell Neurochemistry (060105)
  • Animal Physiology - Cell (060602)
  • Cellular Immunology (110704)
  • Genomics (060408)
  • Animal Immunology (060804)
  • Cell Physiology (111601)

Research Objectives

  • Neurodegenerative Disorders Related to Ageing (920112)
  • Cancer and Related Disorders (920102)
  • Hearing, Vision, Speech and Their Disorders (920107)
  • Digestive System Disorders (920105)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Clinical Health (Organs, Diseases and Abnormal Conditions) (920199)
  • Nervous System and Disorders (920111)
  • Inherited Diseases (incl. Gene Therapy) (920110)
  • Education and Training (939999)
  • Flora, Fauna and Biodiversity at Regional or Larger Scales (960805)
  • Health (929999)
  • Public Health (excl. Specific Population Health) (920499)
  • Learner and Learning Achievement (930101)
  • Diagnostic Methods (920203)
  • Health Status (e.g. Indicators of Well-Being) (920408)
  • Immune System and Allergy (920108)
  • Aboriginal and Torres Strait Islander Health - Determinants of Health (920301)

Publications

All of Dr Cook's papers have been published in peer-reviewed international journals that are well-regarded journals in their area of research. His publication record reflects his skills and experience in development of novel human cell culture models, and their use to model human diseases and phenotypic traits.

Total publications

40

Highlighted publications

(4 outputs)
YearTypeCitationAltmetrics
2015Journal ArticleAshworth Briggs EL, Toh TY, Eri RD, Hewitt A, Cook AL, 'TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients', Molecular Vision, 21 pp. 1162-1172. ISSN 1090-0535 (2015) [Refereed Article]

[eCite] [Details]

Co-authors: Ashworth Briggs EL; Eri RD; Hewitt A

2010Journal ArticleMatigian N, Abrahamsen G, Sutharsan R, Cook AL, Vitale AM, et al., 'Disease-specific, neurosphere-derived cells as models for brain disorders', Disease models & mechanisms, 3, (11) pp. 785-798. ISSN 1754-8403 (2010) [Refereed Article]

DOI: 10.1242/dmm.005447 [eCite] [Details]

Citations: Scopus - 90Web of Science - 83

Tweet

2009Journal ArticleCook AL, Chen W, Thurber AE, Smit DJ, Smith AG, et al., 'Analysis of cultured human melanocytes based on polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5 and OCA2/P loci', The Journal of Investigative Dermatology: An International Journal for Research in Cutaneous Biology, 129, (2) pp. 392-405. ISSN 0022-202X (2009) [Refereed Article]

DOI: 10.1038/jid.2008.211 [eCite] [Details]

Citations: Scopus - 61Web of Science - 53

Tweet

2003Journal ArticleCook AL, Donatien PD, Smith AG, Murphy M, Jones MK, et al., 'Human Melanoblasts in Culture: Expression of BRN2 and Synergistic Regulation by Fibroblast Growth Factor-2, Stem Cell Factor and Endothelin-3', The Journal of Investigative Dermatology: An International Journal for Research in Cutaneous Biology, 121, (5) pp. 1150-1159. ISSN 0022-202X (2003) [Refereed Article]

DOI: 10.1046/j.1523-1747.2003.12562.x [eCite] [Details]

Citations: Scopus - 63Web of Science - 57

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Journal Article

(31 outputs)
YearCitationAltmetrics
2016Gill KP, Hung SSC, Sharov A, Lo CY, Needham K, et al., 'Enriched retinal ganglion cells derived from human embryonic stem cells', Scientific Reports, 6 Article 30552. ISSN 2045-2322 (2016) [Refereed Article]

DOI: 10.1038/srep30552 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Hewitt AW

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2016Hewitt AW, Cook AL, Pebay A, 'Peeking into the molecular trove of discarded surgical specimens', Clinical and Experimental Ophthalmology, 44, (8) pp. 661-662. ISSN 1442-6404 (2016) [Letter or Note in Journal]

DOI: 10.1111/ceo.12837 [eCite] [Details]

Co-authors: Hewitt AW

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2016Murtaza M, Shan J, Matigian N, Todorovic M, Cook AL, et al., 'Rotenone Susceptibility Phenotype in Olfactory Derived Patient Cells as a Model of Idiopathic Parkinson's Disease', PloS one, 11, (4) Article e0154544. ISSN 1932-6203 (2016) [Refereed Article]

DOI: 10.1371/journal.pone.0154544 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2016Randall-Demllo S, Fernando R, Brain T, Sohal SS, Cook AL, et al., 'Characterisation of colonic dysplasia-like epithelial atypia in murine colitis', World journal of gastroenterology, 22, (37) pp. 8334-8348. ISSN 1007-9327 (2016) [Refereed Article]

DOI: 10.3748/wjg.v22.i37.8334 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Randall-Demllo S; Sohal SS; Guven N; Kunde A; Eri R

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2016McCaughey T, Chen CY, De Smit E, Rees G, Fenwick E, et al., 'Participant understanding and recall of informed consent for induced pluripotent stem cell biobanking', Cell and Tissue Banking, 17, (3) pp. 449-456. ISSN 1389-9333 (2016) [Refereed Article]

DOI: 10.1007/s10561-016-9563-8 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Mackey DA; Hewitt AW

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2015Cook AL, Snow ET, Binns HA, Cook PS, 'Self-reported Student Confidence in Troubleshooting Ability Increases After Completion of an Inquiry-Based PCR Practical', Biochemistry and Molecular Biology Education, 43, (5) pp. 316-323. ISSN 1470-8175 (2015) [Refereed Article]

DOI: 10.1002/bmb.20881 [eCite] [Details]

Co-authors: Snow ET; Binns HA; Cook PS

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2015Ashworth Briggs EL, Toh TY, Eri RD, Hewitt A, Cook AL, 'TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients', Molecular Vision, 21 pp. 1162-1172. ISSN 1090-0535 (2015) [Refereed Article]

[eCite] [Details]

Co-authors: Ashworth Briggs EL; Eri RD; Hewitt A

2014Herbert KJ, Cook AL, Snow ET, 'SIRT1 modulates miRNA processing defects in p53-mutated human keratinocytes', Journal of Dermatological Science, 74, (2) pp. 142-149. ISSN 0923-1811 (2014) [Refereed Article]

DOI: 10.1016/j.jdermsci.2014.01.008 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

Co-authors: Herbert KJ; Snow ET

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2014Herbert KJ, Cook AL, Snow ET, 'SIRT1 inhibition restores apoptotic sensitivity in p53-mutated human keratinocytes', Toxicology and Applied Pharmacology, 277, (3) pp. 288-297. ISSN 0041-008X (2014) [Refereed Article]

DOI: 10.1016/j.taap.2014.04.001 [eCite] [Details]

Citations: Scopus - 11Web of Science - 11

Co-authors: Herbert KJ; Snow ET

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2014Herbert KJ, Holloway A, Cook AL, Chin SP, Snow ET, 'Arsenic exposure disrupts epigenetic regulation of SIRT1 in human keratinocytes', Toxicology and Applied Pharmacology, 281, (1) pp. 136-145. ISSN 0041-008X (2014) [Refereed Article]

DOI: 10.1016/j.taap.2014.09.012 [eCite] [Details]

Citations: Scopus - 8Web of Science - 6

Co-authors: Herbert KJ; Holloway A; Chin SP; Snow ET

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2014Eri R, Cook A, Brown N, 'Reflections on the value of mapping the final theory examination in a molecular biochemistry unit', Journal of Microbiology and Biology Education, 15, (1) pp. 53-54. ISSN 1935-7885 (2014) [Refereed Article]

DOI: 10.1128/jmbe.v15i1.679 [eCite] [Details]

Co-authors: Eri R; Brown N

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2013Osmond-McLeod MJ, McLeod RIW, Oytam Y, McCall MJ, Feltis B, et al., 'Surface coatings of ZnO nanoparticles mitigate differentially a host of transcriptional, protein and signalling responses in primary human olfactory cells', Particle and Fibre Toxicology, 10, (54) pp. 1-18. ISSN 1743-8977 (2013) [Refereed Article]

DOI: 10.1186/1743-8977-10-54 [eCite] [Details]

Citations: Scopus - 16Web of Science - 14

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2013Shabala L, Walker EJ, Eklund A, Randall-Demllo S, Shabala S, et al., 'Exposure of colonic epithelial cells to oxidative and endoplasmic reticulum stress causes rapid potassium efflux and calcium influx', Cell Biochemistry and Function, 31, (7) pp. 603-611. ISSN 1099-0844 (2013) [Refereed Article]

DOI: 10.1002/cbf.2946 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Shabala L; Walker EJ; Randall-Demllo S; Shabala S; Guven N; Eri RD

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2011Beaumont KA, Hamilton NA, Moores MT, Cairncross O, Cook AL, et al., 'The Recycling Endosome Protein Rab17 Regulates Melanocytic Filopodia Formation and Melanosome Trafficking', Traffic: The International Journal of Intracellular Transport, 12, (5) pp. 627-43. ISSN 1398-9219 (2011) [Refereed Article]

DOI: 10.1111/j.1600-0854.2011.01172.x [eCite] [Details]

Citations: Scopus - 32Web of Science - 34

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2011Boyle GM, Woods SL, Bonazzi VF, Stark MS, Hacker E, et al., 'Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor', Pigment Cell & Melanoma Research, 24, (3) pp. 525-537. ISSN 1755-148X (2011) [Refereed Article]

DOI: 10.1111/j.1755-148X.2011.00849.x [eCite] [Details]

Citations: Scopus - 81Web of Science - 81

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2011Cook AL, Vitale AM, Ravishankar S, Matigian N, Sutherland GT, et al., 'NRF2 Activation Restores Disease Related Metabolic Deficiencies in Olfactory Neurosphere-Derived Cells from Patients with Sporadic Parkinson's Disease', PLoS ONE, 6, (7) Article E21907. ISSN 1932-6203 (2011) [Refereed Article]

DOI: 10.1371/journal.pone.0021907 [eCite] [Details]

Citations: Scopus - 43Web of Science - 38

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2010Matigian N, Abrahamsen G, Sutharsan R, Cook AL, Vitale AM, et al., 'Disease-specific, neurosphere-derived cells as models for brain disorders', Disease models & mechanisms, 3, (11) pp. 785-798. ISSN 1754-8403 (2010) [Refereed Article]

DOI: 10.1242/dmm.005447 [eCite] [Details]

Citations: Scopus - 90Web of Science - 83

Tweet

2010Stark MS, Tyagi S, Nancarrow DJ, Boyle GM, Cook AL, et al., 'Characterization of the Melanoma miRNAome by Deep Sequencing', PLoS One, 5:e9685, (3) ISSN 1932-6203 (2010) [Refereed Article]

DOI: 10.1371/journal.pone.0009685 [eCite] [Details]

Citations: Scopus - 132Web of Science - 125

Tweet

2009Cook AL, Chen W, Thurber AE, Smit DJ, Smith AG, et al., 'Analysis of cultured human melanocytes based on polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5 and OCA2/P loci', The Journal of Investigative Dermatology: An International Journal for Research in Cutaneous Biology, 129, (2) pp. 392-405. ISSN 0022-202X (2009) [Refereed Article]

DOI: 10.1038/jid.2008.211 [eCite] [Details]

Citations: Scopus - 61Web of Science - 53

Tweet

2009Flammiger A, Besch R, Cook AL, Maier T, Sturm RA, et al., 'SOX9 and SOX10 but Not BRN2 Are Required for Nestin Expression in Human Melanoma Cells', The Journal of Investigative Dermatology: An International Journal for Research in Cutaneous Biology, 129, (4) pp. 945-953. ISSN 0022-202X (2009) [Refereed Article]

DOI: 10.1038/jid.2008.316 [eCite] [Details]

Citations: Scopus - 33Web of Science - 30

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2008Beaumont KA, Shekar SN, Cook AL, Duffy DL, Sturm RA, 'Red hair is the null phenotype of MC1R', Human Mutation, 29, (8) pp. E88-E94. ISSN 1098-1004 (2008) [Refereed Article]

DOI: 10.1002/humu.20788 [eCite] [Details]

Citations: Scopus - 51

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2008Smith AG, Beaumont KA, Smit DJ, Thurber AE, Cook AL, et al., 'PPAR gamma agonists attenuate proliferation and modulate Wnt/a-catenin signalling in melanoma cells', International Journal of Biochemistry and Cell Biology, 41, (4) pp. 844-852. ISSN 1357-2725 (2008) [Refereed Article]

DOI: 10.1016/j.biocel.2008.08.037 [eCite] [Details]

Citations: Scopus - 22Web of Science - 15

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2007Newton RL, Cook AL, Roberts DW, Leonard JH, Sturm RA, 'Post-transcriptional regulation of melanin biosynthetic enzymes by cAMP and resveratrol in human melanocytes', Journal of Investigative Dermatology, 127, (9) pp. 2216-2227. ISSN 0022-202X (2007) [Refereed Article]

DOI: 10.1038/sj.jid.5700840 [eCite] [Details]

Citations: Scopus - 58Web of Science - 54

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2005Cook AL, Smith AG, Smit DJ, Leonard JH, Sturm RA, 'Co-expression of SOX9 and SOX10 during melanocytic differentiation in vitro. Experimental Cell Research', Experimental Cell Research, 308, (1) pp. 222-235. ISSN 0014-4827 (2005) [Refereed Article]

DOI: 10.1016/j.yexcr.2005.04.019 [eCite] [Details]

Citations: Scopus - 47Web of Science - 44

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2004Ven Gele M, Boyle GM, Cook AL, Vandesompele J, Boonefaes T, et al., 'Gene expression profiling reveals distinct expression patterns for Classic versus Variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small cell lung carcinoma', Oncogene, 23, (15) pp. 2732-2742. ISSN 0950-9232 (2004) [Refereed Article]

DOI: 10.1038/sj.onc.1207421 [eCite] [Details]

Citations: Scopus - 44Web of Science - 34

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2003Cook AL, Donatien PD, Smith AG, Murphy M, Jones MK, et al., 'Human Melanoblasts in Culture: Expression of BRN2 and Synergistic Regulation by Fibroblast Growth Factor-2, Stem Cell Factor and Endothelin-3', The Journal of Investigative Dermatology: An International Journal for Research in Cutaneous Biology, 121, (5) pp. 1150-1159. ISSN 0022-202X (2003) [Refereed Article]

DOI: 10.1046/j.1523-1747.2003.12562.x [eCite] [Details]

Citations: Scopus - 63Web of Science - 57

Tweet

2003Leonard JH, Marks LH, Chen W, Cook AL, Boyle GM, et al., 'Screening of human primary melanocytes of defined melanocortin-1 receptor genotype: pigmentation marker, ultrastructural and UV-survival studies', Pigment Cell & Melanoma Research, 16, (3) pp. 198-207. ISSN 1755-148X (2003) [Refereed Article]

DOI: 10.1034/j.1600-0749.2003.00033.x [eCite] [Details]

Citations: Scopus - 37Web of Science - 36

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2002Leonard JH, Cook AL, Van Gele M, Boyle GM, Inglis KJ, et al., 'Proneural and Proneuroendocrine Transcription Factor Expression In Cutaneous Mechanoreceptor (Merkel) Cells and Merkel Cell Carcinoma', International Journal of Cancer, 101, (2) pp. 103-110. ISSN 1097-0215 (2002) [Refereed Article]

DOI: 10.1002/ijc.10554 [eCite] [Details]

Citations: Scopus - 57Web of Science - 59

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2001Cook AL, Pollock PM, Welch J, Walsh MD, Bowman RV, et al., 'CDKN2A is not the principle target of deletions on the short arm of chromosome 9 in neuroendocrine (Merkel cell) carcinoma of the skin', International Journal of Cancer, 93, (3) pp. 361-367. ISSN 1097-0215 (2001) [Refereed Article]

DOI: 10.1002/ijc.1352 [eCite] [Details]

Citations: Scopus - 10Web of Science - 9

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2001Van Gele M, Leonard JH, Van Roy N, Cook AL, De Paepe A, et al., 'Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinoma', International Journal of Cancer, 92, (3) pp. 409-413. ISSN 1097-0215 (2001) [Refereed Article]

DOI: 10.1002/ijc.1209 [eCite] [Details]

Citations: Scopus - 45Web of Science - 41

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2000Leonard JH, Cook AL, Nancarrow D, Hayward N, Van Gele M, et al., 'Deletion mapping on the short arm of chromosome 1 in Merkel cell carcinoma', Cancer Detection and Prevention, 24, (6) pp. 620-627. ISSN 0361-090X (2000) [Refereed Article]

[eCite] [Details]

Citations: Web of Science - 22

Chapter in Book

(3 outputs)
YearCitationAltmetrics
2005Cook AL, Boyle GM, Leonard JH, Parsons PG, Sturm RA, 'BRN2 in melanocytic cell development, differentiation and transformation', From Melanocytes to Melanoma: The Progression of Malignancy, Humana Press Inc, Hearing, VJ, & Leong, APL (ed), Tolowa, New Jersey, pp. 149-168. ISBN 1-58829-459-5 (2005) [Research Book Chapter]

[eCite] [Details]

2003Leonard JH, Cook AL, Van Gele M, Speleman F, Sturm RA, 'Expression of developmentally regulated transcription factors in Merkel cell carcinoma', The Merkel Cell Structure-Development-Function-Cancerogenesis, Springer-Verlag, Bauman, KI, Halata, Z & Moll, I (ed), Germany, pp. 203-218. ISBN 978-3-642-05574-4 (2003) [Research Book Chapter]

[eCite] [Details]

2003Van Gele M, Boyle GM, Cook AL, Boonefaes T, Rottiers P, et al., 'Gene expression profiling reveals two distinct subtypes of Merkel Cell Carcinoma', In: The Merkel Cell Structure-Development-Function-Cancerogensesis, Springer-Verlag, Bauman, KI, Halata, Z & Moll, I (ed), Germany, pp. 195-202. ISBN 978-3-642-05574-4 (2003) [Research Book Chapter]

[eCite] [Details]

Review

(1 outputs)
YearCitationAltmetrics
2008Cook AL, Sturm RA, 'POU domain transcription factors: BRN2 as a regulator of melanocytic growth and tumourigenesis', Pigment Cell and Melanoma Research, 21, (6) pp. 611-626. (2008) [Substantial Review]

[eCite] [Details]

Conference Publication

(4 outputs)
YearCitationAltmetrics
2014Cook AL, 'Defining conditions to direct human pluripotent stem cells towards the glaucoma-affected trabecular meshwork cell lineage', Australian Health & Medical Research Congress, 16-19 November, 2014, Melbourne, Australia (2014) [Conference Extract]

[eCite] [Details]

2014Cook AL, Ashworth Briggs EL, Toh T, Eri RD, Hewitt A, 'Defining conditions to direct human pluripotent stem cells towards the glaucoma-affected trabecular meshwork cell lineage', 2014 Australian Health and Medical Research Congress (AHMRC), 16-19 November, 2014, Melbourne, Australia (2014) [Conference Extract]

[eCite] [Details]

Co-authors: Ashworth Briggs EL; Eri RD; Hewitt A

2014Keith LJ, Briggs ELA, Davidson KC, Wong RCB, Pebay A, et al., 'Defining conditions to direct human pluripotent stem cells towards the glaucoma-affected trabecular meshwork cell lineage', Narrowing the Gap Between Stem Cell Science and Cell Therapy, 9-11 November, 2014, Victoria, Australia (2014) [Conference Extract]

[eCite] [Details]

Co-authors: Keith LJ; Hewitt A

2012Cook AL, Walker EJ, Shan J, Matigian N, Wells CA, et al., 'Nrf2 dysfunction in patient-derived cell lines in a new model of sporadic Parkinsons disease', Proceedings of Keystone Symposium in Molecular and Cellular Biology, 22-27 October 2012, Tokyo, Japan (2012) [Conference Extract]

[eCite] [Details]

Co-authors: Walker EJ

Other Public Output

(1 outputs)
YearCitationAltmetrics
2015Cook AL, 'Researchers see hope for glaucoma sufferers using stem cells', The Mercury, The Mercury, AUGUST 17, 2015 (2015) [Media Interview]

[eCite] [Details]

Grants & Funding

Dr Cook has extensive research experience as a lead or co-investigator on past and current grants from NHMRC, Clifford Craig Medical Research Trust, Cancer Council Tasmania, Cancer Council Queensland, Brain Foundation, and the University of Tasmania.

Funding Summary

Number of grants

19

Total funding

$646,583

Projects

Investigating Batten disease-causing CLN3 mutations in patient-specific stem cells and neurons (2017)$24,898
Description
Batten disease is a rare childhood disease that results in dementia and a progressive loss of vision, and which can be due to mutation of the CLN3 gene. Using advances in stem cell technologies, we will study how the Batten disease-causing mutations in CLN3 differently affect nerve health.
Funding
Royal Hobart Hospital Research Foundation ($24,898)
Scheme
Grant-Establishment
Administered By
University of Tasmania
Research Team
Cook AL; Hewitt A; King AE; Ware T
Year
2017
CRISPR/Cas gene editing of Batten disease genes in patient-specific stem cells (2017)$51,411
Description
Batten disease is a rare childhood disease that results in dementia and a progressive loss of vision, and which can be due to mutation of the several genes, including CLN2 and CLN3. Using advances in stem cell technologies, we will study how the Batten disease-causing mutations in these genes differently affect nerve health.
Funding
Batten Disease Support and Research Association ($51,411)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Cook AL; Hewitt A; King AE; Pebay A; Grubman A
Year
2017
Investigating the utility of retinal Base-Editing (2017)$25,000
Description
The CRISPR/Cas system, used by bacteria to counter viral intrusion, can edit DNA in specific sites. The application of this technology opens the very real prospect of anticipatory cures to well-defined inherited retinal diseases and we propose to expand the pre-clinical investigation of DNA editing of cells in the retina.
Funding
Royal Hobart Hospital Research Foundation ($25,000)
Scheme
Grant-Establishment
Administered By
University of Tasmania
Research Team
Hewitt A; Liu R; Cook AL
Year
2017
CRISPR screen to identify key genes driving DFTD (2017)$33,500
Description
We will apply leading genomic techniques to identify the genes essential for the proliferation of the Tasmanian Devil Facial Tumour. By systematically disrupting each gene in the cancer, we will also identify genes which help the tumour evade the immune system.
Funding
University of Tasmania Foundation Inc ($33,500)
Scheme
Grant-Dr Eric Guiler Tasmanian Devil Research Gran
Administered By
University of Tasmania
Research Team
Hewitt A; Liu G; Woods GM; Flies AS; Cook AL
Year
2017
Using stem cells to understand glaucoma (2016)$50,000
Description
Glaucoma is the leading cause of irreversible blindness worldwide and there is currently no definitive treatment for this common disease. We have recently identified a number of genes associated with glaucoma, and we now seek to use this new genetic insight to test potentialdrug targets. This work will provide data that will lead directly to pre-clinical testing of FDAapproved drugs, and which may ultimately identify novel treatments for this devastating disease.
Funding
Ophthalmic Research Institute of Australia ($50,000)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Cook AL; Hewitt A
Year
2016
Optimisation of CRISPR/Cas gene editing in the retina. (2016 - 2017)$72,634
Description
Investigate the efficacy of single Clustered Regularly Interspersed Short Palindromic Repeat (CRISPR) and CRISPR-associated (Cas) plasmids for gene editing in the retina.Validate our novel self-destructing CRISPR/Cas system and ensure, after initial activity, no functional CRISPR/Cas protein is produced.
Funding
Bayer Pharma AG ($72,634)
Scheme
Award-Global Ophthalmology Awards
Administered By
University of Tasmania
Research Team
Hewitt A; Cook AL
Period
2016 - 2017
Towards a patient-specific stem cell model of the blinding eye disease glaucoma (2015)$71,000
Funding
Clifford Craig Foundation ($71,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Cook AL; Hewitt Alex; Pebay A; Keith LJ
Year
2015
The landscape of gene expression changes in the aqueous humor drainage pathway of glaucoma patients (2015)$36,300
Description
The aims of this project are to: 1) define the entirety of genes expressed within the trabecular meshwork samples of glaucoma patients and controls; 2) correlate glaucoma-specific trabecular meshwork gene expression signatures to clinical parameters.
Funding
Clifford Craig Foundation ($36,300)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Cook AL; Toh TY; Kunde DA; Hewitt Alex
Year
2015
Extracellular matrix remodelling in the glaucomatous trabecular meshwork (2014)$36,235
Description
Glaucoma is a degenerative disease attributed to progressive loss of neurons within the optic nerve. There is no cure for this disease, with treatment strategies predominantly focused on reducing intraocular pressure (IOP), which remains the only modifiable risk factor. IOP is generally considered to be due to inhibited outflow of aqueous humor, the fluid within the eye, through a specialised tissue known as the trabecular meshwork. The trabecular meshwork (TM) is highly fibrous, consisting of several layers of cells overlying extracellular matrix (ECM) structures. During normal ageing, increased ECM deposition occurs in the deeper layers of the trabecular meshwork, and this appears to be increased in glaucoma. It is not known how this occurs, but it has been speculated that changes in expression and activity of ECM remodelling proteins, typified by matrix metalloproteinases (MMPs) and their regulators, tissue inhibitor of metalloproteinases (TIMPs), may be responsible. Several studies have examined gene expression and the ECM structure in normal and glaucomatous trabecular meshwork, as well as the presence of MMPs and TIMPS in aqueous humor, but no study has attempted to correlate the extent of ECM deposition with MMP or TIMP activity using trabecular meshwork tissue and aqueous humor from the same patient.
Funding
Clifford Craig Foundation ($36,235)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Cook AL; Toh TY; Hewitt Alex; Eri RD
Year
2014
Optimizing trabecular meshwork differentiation (2014)$14,500
Funding
University of Tasmania ($14,500)
Scheme
Grant-Research Enhancement (REGS)
Administered By
University of Tasmania
Research Team
Cook AL
Year
2014
Investigation of carcinogenesis pathways in colitis-associated colorectal cancer (2014)$24,409
Description
The aims of the project are: to study the expression levels of different inflammation molecules and inflammasome components in ulcerative colities patients, UC-associated-colorectal patients, sporadic colorectal patients compared to controls; to identify the cell populations where different inflammasome components are localised.
Funding
Clifford Craig Foundation ($24,409)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Eri RD; Lloyd D; Mitchell BL; Fanning S; Ahuja KDK; Cook AL
Year
2014
The INK4 locus in glaucoma - functional assessment of the non-coding RNA gene ANRIL in patient-specific cells (2013)$27,273
Funding
Clifford Craig Foundation ($27,273)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Cook AL; Eri RD; Hewitt Alex; Toh TY
Year
2013
Understanding the role of inflammasomes in inflammatory bowel disease (IBD) (2013 - 2014)$54,546
Funding
Clifford Craig Foundation ($54,546)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Eri RD; Cook AL; Mitchell BL; Wilson Raymond
Period
2013 - 2014
Investigation of carcinogenesis pathways in colitis-associated colorectal cancer (Scholarship Sarron Randall-Demllo) (2013 - 2015)$54,000
Funding
Australian Rotary Health Research Fund ($54,000)
Scheme
Scholarship-Funding Partners
Administered By
University of Tasmania
Research Team
Eri RD; Spring K; Cook AL
Period
2013 - 2015
Glaucoma Fibroblast Cultures (2012)$10,000
Description
The project aims to establish and bank glaucoma patient-specific fibroblast cell lines and conduct molecular analyses on these cell lines.
Funding
Centre for Eye Research Aust Ltd ($10,000)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Cook AL; Eri RD
Year
2012
2012: Ageing and Diseases of Ageing, Japan (2012)$1,300
Funding
University of Tasmania ($1,300)
Scheme
Grant-Conference Support Scheme
Administered By
University of Tasmania
Research Team
Cook AL
Year
2012
Epigenetic Regulation of Tumour Supressors in Skin Cancer (2012)$22,300
Funding
Cancer Council of Tasmania ($22,300)
Scheme
Grant-Small
Administered By
University of Tasmania
Research Team
Cook AL; Snow ET; Holloway AF
Year
2012
Protein recycling is disrupted in Parkinson's disease (2011)$15,277
Funding
University of Tasmania ($15,277)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Cook AL
Year
2011
Protein Recycling is Disrupted in Parkinson's Disease (2010)$22,000
Funding
Brain Foundation ($22,000)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Cook AL
Year
2010

Research Supervision

Dr Cook has successfully supervised one PhD student to completion (now at Oxford University, UK) as well as a Masters and several Honours students. He currently supervises several PhD candidates both in a primary and co-supervisory capacity. Dr Cook is interested in hearing from high performing prospective students eager to gain experience in stem cell-based approaches to modelling of neurodegenerative diseases.

Current

6

Completed

2

Current

DegreeTitleCommenced
PhDTrabecular Meshwork Dysfunction in Glaucoma using Patient-specific iPS Cells2013
PhDThe Role of Inflammasomes in the Pathogenesis of Inflammatory Bowel Disease2014
PhDUsing Pluripotent Stem Cells to Model AMD2015
PhDBioinformatics Methods to Improve Drug Discovery2015
PhDDissecting the Utility of Stem Cell Derived Tissue for Disease Modelling2015
PhDRetinal nerve Profile in Cognitive Decline and Dementia2015

Completed

DegreeTitleCompleted
PhDInvestigation of Neoplastic Transition of the Colonic Epithelium in the Winnie Mouse Model of Chronic Colitis
Candidate: Sarron Yael Randall-Demllo
2017
PhDEpigenetic mechanisms of arsenic-induced transformation in human keratinocytes
Candidate: Katharine Jane Herbert
2014