Molecular mechanisms of treatment response - The Brettingham-Moore Group
Our research involves profiling the mechanisms involved in cancer treatment resistance with the aim of identifying predictive markers of response.
We are interested in why some patients are resistant to cancer therapies. Using a prostate cancer cell line model we are profiling the differences between resistant and sensitive cells to determine the mechanisms of treatment resistance and the epigenetic mechanisms involved in DNA repair.
Expertise
- Epigenetics
- Cancer Genetics & Cell Biology
- Gene Expression
- Molecular Targets
- Radiation Therapy
- Genome Structure and Regulation
Projects
The impact of repeated DNA damage on the molecular profile of prostate cancer cells.
This project is investigating how prostate cancer cells are altered by exposure to repeated DNA damage. The proliferative and invasive capacity of the cells and their altered transcriptional programs are being characterised to identify molecular drivers of resistance to treatment and metastasis.
Investigating the role of DNA methylation in response to DNA damage.
Profiling stable DNA methylation changes in prostate cancer cells to determine the epigenetic impact of DNA damage and repair
Epigenetic mechanisms in DNA repair.
In this project protein localisation to double strand breaks will be characterised along with chromatin remodelling events.
Group Leader(s)
Affiliation
Biomedical Sciences
School of Medicine
Contact
Email: kate.brettinghammoore@utas.edu.au
Group members
Dayna Challis
Matthew Davis
Additional Information
Please contact Kate via email if you are interested in PhD or Honours projects kate.brettinghammoore@utas.edu.au