Profiles

Jason A Smith

UTAS Home Assoc Prof Jason A Smith
Jason Smith

Jason A Smith

Head of Discipline, Chemistry

Room 204 , Chemistry Building

+61 3 6226 2182 (phone)

+61 3 6226 2858 (fax)

Jason.Smith@utas.edu.au

Dr Jason A Smith is a Senior Lecturer in Chemistry and carries out research in the area of Organic Chemistry, designing and synthesising new molecules for Drug Discovery.  He studies the role of organic molecules in living systems, such as determining the role of plant hormones in plant health and crop yield. Organic Chemistry plays a major role in improving society by developing new drugs to combat disease and understanding chemical processes of plants to improve food security.

Biography

Jason is a graduate of Flinders University of South Australia where he obtained both his BSc (Hons) and PhD. He has carried out post-doctoral research at Texas A&M (with Nobel Laureate Prof Sir Derek HR Barton) and at Australian National University (Prof Martin Banwell). In 1999 he received an AMRAD postdoctoral award and the RACI Athel Beckwith Lectureship in 2005.

Career summary

Qualifications

  • PhD: Flinders University (1997)
  • BSc (Hons): Flinders University (1993)
  • BSc: Flinders University (1992)

Memberships

Committee associations

  • Royal Australian Chemical Institute

Teaching

Organic Chemistry, Medicinal Chemistry, Natural Products, Reaction Mechanisms, Spectroscopy, Biosynthesis

Teaching expertise

Jason's area of teaching is in organic chemistry and includes the structure, shape and reactivity of organic molecules and methods for determining chemical structure.  The role and connections of organic chemistry to other disciplines is highlighted in pharmaceutical sciences, medical applications, drug design and the role of organic molecules in nature and how nature produces important compounds.

Teaching responsibility

General organic chemistry and biosynthesis of alkaloids

View more on AssocProf Jason Smith in WARP

Expertise

Jason's research activities focus on the development of new synthetic methodology and its application to the synthesis of biologically active or structurally complex molecules. This includes exploiting pyrrole as a molecular template for the rapid construction of alkaloids. Other research areas involve the development of new methods for carrying out demanding organic transformations, the determination of organic reaction mechanisms, applications in biosynthesis and the synthesis of potential drug candidates for particular diseases.  A recent development in our laboratories has been the development of pressured hot water extraction (PHWE) for natural product isolation.  Jason also has an active research program on the synthesis and roles of plant hormones.

Awards

  • AMRAD postdoctoral award – 1999
  • RACI Athel Beckwith Lectureship - 2005

Current projects

Fields of Research

  • Organic Chemical Synthesis (030503)
  • Natural Products Chemistry (030502)
  • Plant Physiology (060705)
  • Pharmaceutical Sciences (111504)
  • Organic Chemistry (030599)
  • Transition Metal Chemistry (030207)
  • Separation Science (030108)
  • Free Radical Chemistry (030501)
  • Chemical Sciences (039999)
  • Physical Organic Chemistry (030505)
  • Biologically Active Molecules (030401)
  • Structural Biology (incl. Macromolecular Modelling) (060112)
  • Medical Bacteriology (110801)
  • Plant Developmental and Reproductive Biology (060703)
  • Catalysis and Mechanisms of Reactions (030601)
  • Medicinal and Biomolecular Chemistry (030499)
  • Neurology and Neuromuscular Diseases (110904)
  • Forestry Pests, Health and Diseases (070505)
  • Organometallic Chemistry (039904)
  • Instrumental Methods (excl. Immunological and Bioassay Methods) (030105)
  • Horticultural Crop Protection (Pests, Diseases and Weeds) (070603)
  • Oenology and Viticulture (070604)
  • Infectious Diseases (110309)
  • Genomics (060408)
  • Complementary and Alternative Medicine (110499)
  • Pharmacology and Pharmaceutical Sciences (111599)
  • Algebra and Number Theory (010101)
  • Ophthalmology (111301)
  • Basic Pharmacology (111501)
  • Tree Nutrition and Physiology (070508)
  • Invertebrate Biology (060808)
  • Aquaculture (070401)
  • Analytical Chemistry (030199)
  • Industrial Chemistry (039903)
  • Medical Biotechnology (100499)
  • Clinical Pharmacology and Therapeutics (111502)
  • Medical Virology (110804)
  • Crop and Pasture Biochemistry and Physiology (070303)
  • Characterisation of Biological Macromolecules (030403)
  • Immunological and Bioassay Methods (030104)
  • Analytical Spectrometry (030101)
  • Conservation and Biodiversity (050202)
  • Main Group Metal Chemistry (030204)
  • Plant Cell and Molecular Biology (060702)
  • f-Block Chemistry (030202)
  • Soil Physics (050305)

Research Objectives

  • Expanding Knowledge in the Chemical Sciences (970103)
  • Infectious Diseases (920109)
  • Human Pharmaceutical Products (860899)
  • Human Pharmaceutical Treatments (e.g. Antibiotics) (860803)
  • Expanding Knowledge in the Biological Sciences (970106)
  • Hardwood Plantations (820101)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Expanding Knowledge in the Environmental Sciences (970105)
  • Plant Production and Plant Primary Products (829999)
  • Environmentally Sustainable Plant Production (829899)
  • Organic Industrial Chemicals (excl. Resins, Rubber and Plastics) (860604)
  • Preventive Medicine (920412)
  • Clinical Health (Organs, Diseases and Abnormal Conditions) (920199)
  • Control of Animal Pests, Diseases and Exotic Species in Farmland, Arable Cropland and Permanent Cropland Environments (960403)
  • Renewable Energy (850599)
  • Air Force (810101)
  • Hearing, Vision, Speech and Their Disorders (920107)
  • Industrial Chemicals and Related Products (860699)
  • Summer Grains and Oilseeds (820499)
  • Rice (820402)
  • Environment (969999)
  • Control of Pests, Diseases and Exotic Species in Urban and Industrial Environments (960411)
  • Grain Legumes (820503)
  • Wine Grapes (820306)
  • Horticultural Crops (820299)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Animal Protection Chemicals (860701)
  • Nervous System and Disorders (920111)
  • Scientific Instruments (861503)
  • Veterinary Pharmaceutical Treatments (e.g. Antibiotics) (860903)
  • Bakery Products (860101)
  • Fisheries - Aquaculture (830199)
  • Environmentally Sustainable Manufacturing (869899)
  • Vegetables (820215)
  • Industrial Instruments (861501)
  • Cancer and Related Disorders (920102)
  • Diagnostic Methods (920203)
  • Respiratory System and Diseases (incl. Asthma) (920115)
  • Environmentally Sustainable Mineral Resource Activities (849899)

Publications

Total publications

87

Highlighted publications

(9 outputs)
YearTypeCitationAltmetrics
2015Journal ArticleJust J, Deans BJ, Olivier WJ, Paull B, Bissember AC, et al., 'New method for the rapid extraction of natural products: efficient isolation of shikimic acid from star anise', Organic Letters, 17, (10) pp. 2428-2430. ISSN 1523-7060 (2015) [Refereed Article]

DOI: 10.1021/acs.orglett.5b00936 [eCite] [Details]

Citations: Scopus - 34Web of Science - 33

Co-authors: Just J; Deans BJ; Olivier WJ; Paull B; Bissember AC

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2015Journal ArticleJust J, Jordan TB, Paull B, Bissember AC, Smith JA, 'Practical isolation of polygodial from Tasmannia lanceolata: a viable scaffold for synthesis', Organic and Biomolecular Chemistry, 13, (46) pp. 11200-11207. ISSN 1477-0520 (2015) [Refereed Article]

DOI: 10.1039/c5ob01573a [eCite] [Details]

Citations: Scopus - 25Web of Science - 25

Co-authors: Just J; Jordan TB; Paull B; Bissember AC

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2013Journal ArticleHoward JK, Hyland CJT, Just J, Smith JA, 'Controlled oxidation of pyrroles: synthesis of highly functionalized γ-lactams', Organic Letters, 15, (7) pp. 1714-1717. ISSN 1523-7060 (2013) [Refereed Article]

DOI: 10.1021/ol400491p [eCite] [Details]

Citations: Scopus - 18Web of Science - 17

Co-authors: Howard JK; Hyland CJT; Just J

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2010Journal ArticleTivendale ND, Davies NW, Molesworth PP, Davidson SE, Smith JA, et al., 'Reassessing the role of N-Hydroxytryptamine in auxin biosynthesis', Plant Physiology, 154, (4) pp. 1957-1965. ISSN 0032-0889 (2010) [Refereed Article]

DOI: 10.1104/pp.110.165803 [eCite] [Details]

Citations: Scopus - 48Web of Science - 45

Co-authors: Tivendale ND; Davies NW; Molesworth PP; Davidson SE; Lowe EK; Reid JB; Ross JJ

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2008Journal ArticleAmos RIJ, Gourlay BS, Schiesser CH, Smith Jason, Yates BF, 'A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid', Chemical Communications, 2008, (14) pp. 1695-1697. ISSN 1359-7345 (2008) [Refereed Article]

DOI: 10.1039/b719570b [eCite] [Details]

Citations: Scopus - 30Web of Science - 27

Co-authors: Amos RIJ; Gourlay BS; Yates BF

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2008Journal ArticleGourlay BS, Ryan JH, Smith Jason, 'Knorr-Rabe partial reduction of pyrroles: Application to the synthesis of indolizidine alkaloids', Beilstein Journal of Organic Chemistry, 4, (3) EJ ISSN 1860-5397 (2008) [Refereed Article]

DOI: 10.1186/1860-5397-4-3 [eCite] [Details]

Citations: Scopus - 8Web of Science - 12

Co-authors: Gourlay BS

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2006Journal ArticleBolton K, Canty AJ, Deverell JA, Guijt RM, Hilder EF, et al., 'Macroporous monolith supports for continuous flow capillary microreactors', Tetrahedron Letters, 47, (52) pp. 9321-9324. ISSN 0040-4039 (2006) [Refereed Article]

DOI: 10.1016/j.tetlet.2006.10.113 [eCite] [Details]

Citations: Scopus - 41Web of Science - 37

Co-authors: Bolton K; Canty AJ; Deverell JA; Guijt RM; Hilder EF; Rodemann T

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2006Journal ArticleGourlay BS, Molesworth PP, Ryan JH, Smith JA, 'A new and high yielding synthesis of unstable pyrroles via a modified Clauson-Kaas reaction', Tetrahedron Letters, 47, (5) pp. 799-801. ISSN 0040-4039 (2006) [Refereed Article]

DOI: 10.1016/j.tetlet.2005.11.104 [eCite] [Details]

Citations: Scopus - 37Web of Science - 38

Co-authors: Gourlay BS; Molesworth PP

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2006Journal ArticleSmith JA, Ng M, White J, 'The regioselective synthesis of aryl pyrroles', Organic and Biomolecular Chemistry, 4, (12) pp. 2477-2482. ISSN 1477-0520 (2006) [Refereed Article]

DOI: 10.1039/b604692d [eCite] [Details]

Citations: Scopus - 36Web of Science - 38

Co-authors: Ng M

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Journal Article

(72 outputs)
YearCitationAltmetrics
2020Deans BJ, Just J, Tedone L, Kilah NL, Jordan GJ, et al., 'Distinct drimane chemotypes in Tasmanian Mountain Pepper (Tasmannia lanceolata): Differences in the profiles of pungent leaf phytochemicals associated with altitudinal cline', Journal of Agricultural and Food Chemistry, 68 pp. 315−322. ISSN 1520-5118 (2020) [Refereed Article]

DOI: 10.1021/acs.jafc.9b05703 [eCite] [Details]

Co-authors: Deans BJ; Just J; Tedone L; Kilah NL; Jordan GJ; Bissember AC

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2019Chipman A, Farshadfar K, Smith JA, Yates BF, Ariafard A, 'DFT-based comparison between mechanistic aspects of amine and alcohol oxidation mediated by IBX', Journal of Organic Chemistry, 85, (2) pp. 515-525. ISSN 0022-3263 (2019) [Refereed Article]

DOI: 10.1021/acs.joc.9b02583 [eCite] [Details]

Co-authors: Chipman A; Yates BF; Ariafard A

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2019Turner DN, Just J, Dasari R, Smith JA, Bissember AC, et al., 'Activity of natural and synthetic polygodial derivatives against Trypanosoma cruzi amastigotes, trypomastigotes and epimastigotes', Natural Product Research pp. 1-4. ISSN 1478-6419 (2019) [Refereed Article]

DOI: 10.1080/14786419.2019.1597350 [eCite] [Details]

Co-authors: Just J; Bissember AC

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2019Woolley KL, Nadikudi M, Koupaei MN, Corban M, McCartney P, et al., 'Amide linked redox-active naphthoquinones for the treatment of mitochondrial dysfunction', MedChemComm, 10, (3) pp. 399-412. ISSN 2040-2511 (2019) [Refereed Article]

DOI: 10.1039/c8md00582f [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Woolley KL; Nadikudi M; Corban M; Bissember AC; Lewis TW; Gueven N

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2018De La Chapa J, Singha PK, Sallaway M, Self K, Nasreldin R, et al., 'Novel polygodial analogs P3 and P27: Efficacious therapeutic agents disrupting mitochondrial function in oral squamous cell carcinoma', International Journal of Oncology, 53, (6) pp. 2627-2636. ISSN 1019-6439 (2018) [Refereed Article]

DOI: 10.3892/ijo.2018.4585 [eCite] [Details]

Citations: Scopus - 1Web of Science - 2

Co-authors: Just J; Bissember AC

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2018Deans BJ, Kilah NL, Jordan GJ, Bissember AC, Smith JA, 'Arbutin derivatives isolated from ancient proteaceae: potential phytochemical markers present in Bellendena, Cenarrhenes, and Persoonia Genera', Journal of Natural Products, 81, (5) pp. 1241-1251. ISSN 0163-3864 (2018) [Refereed Article]

DOI: 10.1021/acs.jnatprod.7b01038 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

Co-authors: Deans BJ; Kilah NL; Jordan GJ; Bissember AC

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2018Deans BJ, Olivier WJ, Girbino D, Bissember AC, Smith JA, 'Extraction of carboxylic acid-containing diterpenoids from Dodonaea viscosa via pressurised hot water extraction', Fitoterapia, 126 pp. 65-68. ISSN 0367-326X (2018) [Refereed Article]

DOI: 10.1016/j.fitote.2017.10.008 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Deans BJ; Olivier WJ; Bissember AC

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2018Deans BJ, Skierka BE, Karagiannakis BW, Vuong D, Lacey E, et al., 'Siliquapyranone: a tannic acid Tetrahydropyran-2-one isolated from the leaves of carob (Ceratonia siliqua) by pressurised hot water extraction', Australian Journal of Chemistry, 71, (9) pp. 702-707. ISSN 0004-9425 (2018) [Refereed Article]

DOI: 10.1071/CH18265 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Deans BJ; Skierka BE; Bissember AC

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2018Deans BJ, Tedone L, Bissember AC, Smith JA, 'Phytochemical profile of the rare, ancient clone Lomatia tasmanica and comparison to other endemic Tasmanian species L. tinctoria and L. polymorpha', Phytochemistry, 153 pp. 74-78. ISSN 0031-9422 (2018) [Refereed Article]

DOI: 10.1016/j.phytochem.2018.05.019 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Deans BJ; Tedone L; Bissember AC

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2018Deans BJ, de Salas M, SMith JA, Bissember AC, 'Natural products isolated from endemic Tasmanian vascular plants', Australian Journal of Chemistry, 71, (10) pp. 756-767. ISSN 0004-9425 (2018) [Refereed Article]

DOI: 10.1071/CH18283 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Deans BJ; de Salas M; Bissember AC

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2018Ho CC, Deans BJ, Just J, Warr GG, Wilkinson S, et al., 'Employing pressurized hot water extraction (PHWE) to explore natural products chemistry in the undergraduate laboratory', Journal of Visualized Experiments, 141 Article e58195. ISSN 1940-087X (2018) [Refereed Article]

DOI: 10.3791/58195 [eCite] [Details]

Co-authors: Ho CC; Deans BJ; Just J; Bissember AC

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2018Ho CC, Olding A, Smith JA, Bissember AC, 'Nuances in fundamental Suzuki−Miyaura cross-couplings employing [Pd(PPh3)4]: poor reactivity of aryl Iodides at lower temperatures', Organometallics, 37, (11) pp. 1745-1750. ISSN 0276-7333 (2018) [Refereed Article]

DOI: 10.1021/acs.organomet.8b00189 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Ho CC; Olding A; Bissember AC

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2018Hyland IK, O'Toole RF, Smith JA, Bissember AC, 'Progress in the development of Platelet-Activating Factor Receptor (PAFr) antagonists and applications in the treatment of inflammatory diseases', ChemMedChem, 13, (18) pp. 1873-1884. ISSN 1860-7179 (2018) [Refereed Article]

DOI: 10.1002/cmdc.201800401 [eCite] [Details]

Citations: Scopus - 6Web of Science - 5

Co-authors: Hyland IK; O'Toole RF; Bissember AC

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2018Olivier WJ, Gardiner MG, Bissember AC, Smith JA, 'Brønsted acid-mediated annulations of pyrroles featuring N-tethered α,β-unsaturated ketones and esters: total syntheses of (±)-tashiromine and (±)-indolizidine 209I', Tetrahedron, 74, (38) pp. 5436-5441. ISSN 0040-4020 (2018) [Refereed Article]

DOI: 10.1016/j.tet.2018.04.067 [eCite] [Details]

Citations: Scopus - 2Web of Science - 1

Co-authors: Olivier WJ; Gardiner MG; Bissember AC

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2018Olivier WJ, Smith JA, Bissember AC, 'Methods for the synthesis of annulated pyrroles via cyclisation strategies', Organic and Biomolecular Chemistry, 16, (8) pp. 1216-1226. ISSN 1477-0520 (2018) [Refereed Article]

DOI: 10.1039/C7OB03144K [eCite] [Details]

Citations: Scopus - 20Web of Science - 17

Co-authors: Olivier WJ; Bissember AC

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2018Pullen R, Olding A, SMith JA, Bissember AC, 'Capstone laboratory experiment investigating key features of palladium-catalyzed Suzuki-Miyaura cross-coupling reactions', Journal of Chemical Education pp. 1-5. ISSN 0021-9584 (2018) [Refereed Article]

DOI: 10.1021/acs.jchemed.7b00964 [eCite] [Details]

Citations: Scopus - 5Web of Science - 6

Co-authors: Pullen R; Olding A; Bissember AC

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2018Rihak KJ, Bissember AC, Smith JA, 'Polygodial: a viable natural product scaffold for the rapid synthesis of novel polycyclic pyrrole and pyrrolidine derivatives', Tetrahedron, 74, (12) pp. 1167-1174. ISSN 0040-4020 (2018) [Refereed Article]

DOI: 10.1016/j.tet.2017.10.015 [eCite] [Details]

Citations: Scopus - 6Web of Science - 5

Co-authors: Rihak KJ; Bissember AC

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2017Deans BJ, Just J, Chhetri J, Burt LK, Smith JN, et al., 'Pressurized hot water extraction as a viable bioprospecting tool: isolation of coumarin natural products from previously unexamined Correa (Rutaceae) species', ChemistrySelect, 2, (8) pp. 2439-2443. ISSN 2365-6549 (2017) [Refereed Article]

DOI: 10.1002/slct.201602006 [eCite] [Details]

Citations: Scopus - 9Web of Science - 9

Co-authors: Deans BJ; Just J; Chhetri J; Burt LK; Smith JN; Kilah NL; Guven N; Bissember AC

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2017Kunde DA, Chong WC, Nerurkar PV, Ahuja KDK, Just J, et al., 'Bitter melon protects against ER stress in LS174T colonic epithelial cells', BMC Alternative Medicine, 17 Article 2. ISSN 1472-6882 (2017) [Refereed Article]

DOI: 10.1186/s12906-016-1522-1 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Kunde DA; Chong WC; Ahuja KDK; Just J; Guven N; Eri RD

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2016Cook SD, Nichols DS, Smith J, Chourey PS, McAdam EL, et al., 'Auxin biosynthesis: are the indole-3-acetic acid and phenylacetic acid biosynthesis pathways mirror images?', Plant Physiology, 171, (2) pp. 1230-1241. ISSN 0032-0889 (2016) [Refereed Article]

DOI: 10.1104/pp.16.00454 [eCite] [Details]

Citations: Scopus - 19Web of Science - 20

Co-authors: Cook SD; Nichols DS; McAdam EL; Quittenden L; Ross JJ

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2016Deans BJ, Bissember AC, Smith JA, 'Practical Isolation of Asperuloside from Coprosma quadrifida via Rapid Pressurised Hot Water Extraction', Australian Journal of Chemistry, 69, (11) pp. 1219-1222. ISSN 0004-9425 (2016) [Refereed Article]

DOI: 10.1071/CH15743 [eCite] [Details]

Citations: Scopus - 10Web of Science - 10

Co-authors: Deans BJ; Bissember AC

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2016Foo E, Blake SN, Fisher BJ, Smith JA, Reid JB, 'The role of strigolactones during plant interactions with the pathogenic fungus Fusarium oxysporum', Planta, 243, (6) pp. 1387-1396. ISSN 0032-0935 (2016) [Refereed Article]

DOI: 10.1007/s00425-015-2449-3 [eCite] [Details]

Citations: Scopus - 16Web of Science - 15

Co-authors: Foo E; Blake SN; Fisher BJ; Reid JB

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2016Howard JK, Rihak KJ, Bissember AC, Smith JA, 'The oxidation of pyrrole', Chemistry - An Asian Journal, 11, (2) pp. 155-167. ISSN 1861-4728 (2016) [Refereed Article]

DOI: 10.1002/asia.201500659 [eCite] [Details]

Citations: Scopus - 21Web of Science - 22

Co-authors: Howard JK; Rihak KJ; Bissember AC

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2016Howard JK, Rihak KJ, Hyland CJT, Bissember AC, Smith JA, 'Visible light dye-photosensitised oxidation of pyrroles using a simple LED photoreactor', Organic and Biomolecular Chemistry, 14, (37) pp. 8873-8880. ISSN 1477-0520 (2016) [Refereed Article]

DOI: 10.1039/c6ob01719c [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Howard JK; Rihak KJ; Hyland CJT; Bissember AC

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2016Just J, Bunton GL, Deans BJ, Murray NL, Bissember AC, et al., 'Extraction of Eugenol from Cloves Using an Unmodified Household Espresso Machine: An Alternative to Traditional Steam-Distillation', Journal of Chemical Education, 93, (1) pp. 213-216. ISSN 0021-9584 (2016) [Refereed Article]

DOI: 10.1021/acs.jchemed.5b00476 [eCite] [Details]

Citations: Scopus - 20Web of Science - 22

Co-authors: Just J; Bunton GL; Deans BJ; Bissember AC

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2016Olivier WJ, Kilah NL, Horne J, Bissember AC, Smith JA, 'ent-Labdane Diterpenoids from Dodonaea viscosa', Journal of Natural Products, 79, (12) pp. 3117-3126. ISSN 0163-3864 (2016) [Refereed Article]

DOI: 10.1021/acs.jnatprod.6b00858 [eCite] [Details]

Citations: Scopus - 5Web of Science - 6

Co-authors: Olivier WJ; Kilah NL; Horne J; Bissember AC

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2016Quarrell SR, Davies NW, Walker PW, Corkrey R, Smith JA, et al., 'Identification of the putative aggregation pheromone components emitted by the European earwig, Forficula auricularia', Chemoecology, 26, (5) pp. 173-186. ISSN 0937-7409 (2016) [Refereed Article]

DOI: 10.1007/s00049-016-0216-y [eCite] [Details]

Citations: Scopus - 4Web of Science - 3

Co-authors: Quarrell SR; Davies NW; Walker PW; Corkrey R; Allen GR

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2015Abel S-AG, Olivier WJ, Pederson RL, Bissember AC, Smith JA, 'Complete stereocontrol in the synthesis of harmonine and novel analogues facilitated by a Grubbs Z-selective cross-metathesis catalysis', Australian Journal of Chemistry, 68, (12) pp. 1815-1820. ISSN 0004-9425 (2015) [Refereed Article]

DOI: 10.1071/CH15397 [eCite] [Details]

Citations: Scopus - 3Web of Science - 1

Co-authors: Abel S-AG; Olivier WJ; Bissember AC

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2015Bromhead LJ, Smith J, McErlean CSP, 'Chemistry of the synthetic strigolactone mimic GR24', Australian Journal of Chemistry, 68, (8) pp. 1221-1227. ISSN 0004-9425 (2015) [Refereed Article]

DOI: 10.1071/CH15298 [eCite] [Details]

Citations: Scopus - 2Web of Science - 3

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2015Guven N, Woolley K, Smith J, 'Border between natural product and drug: comparison of the related benzoquinones idebenone and coenzyme Q10', Redox Biology, 4 pp. 289-295. ISSN 2213-2317 (2015) [Refereed Article]

DOI: 10.1016/j.redox.2015.01.009 [eCite] [Details]

Citations: Scopus - 43Web of Science - 40

Co-authors: Guven N; Woolley K

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2015Just J, Deans BJ, Olivier WJ, Paull B, Bissember AC, et al., 'New method for the rapid extraction of natural products: efficient isolation of shikimic acid from star anise', Organic Letters, 17, (10) pp. 2428-2430. ISSN 1523-7060 (2015) [Refereed Article]

DOI: 10.1021/acs.orglett.5b00936 [eCite] [Details]

Citations: Scopus - 34Web of Science - 33

Co-authors: Just J; Deans BJ; Olivier WJ; Paull B; Bissember AC

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2015Just J, Jordan TB, Paull B, Bissember AC, Smith JA, 'Practical isolation of polygodial from Tasmannia lanceolata: a viable scaffold for synthesis', Organic and Biomolecular Chemistry, 13, (46) pp. 11200-11207. ISSN 1477-0520 (2015) [Refereed Article]

DOI: 10.1039/c5ob01573a [eCite] [Details]

Citations: Scopus - 25Web of Science - 25

Co-authors: Just J; Jordan TB; Paull B; Bissember AC

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2015Tivendale ND, Davies NW, Horne J, Ross JJ, Smith JA, 'Analysis of the enol-keto tautomers of indole-3-pyruvic acid', Australian Journal of Chemistry, 68, (2) pp. 345-348. ISSN 0004-9425 (2015) [Refereed Article]

DOI: 10.1071/CH14343 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Tivendale ND; Davies NW; Horne J; Ross JJ

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2014Abel SAG, Eglinton MO, Howard JK, Hunt DJ, Prager RH, et al., 'Synthesis of heterocyclic-fused imidazoles by pyrolysis of N-heterocyclic isoxazol-5(2H)-ones', Australian Journal of Chemistry, 67, (9) pp. 1228-1233. ISSN 0004-9425 (2014) [Refereed Article]

DOI: 10.1071/CH14119 [eCite] [Details]

Citations: Scopus - 2Web of Science - 3

Co-authors: Abel SAG; Howard JK

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2014Deans RM, Gardiner MG, Horne J, Hung AC, Hyland CJT, et al., 'Isolation and characterization of 1β-Acetoxypolygodial from Tasmannia Lanceolata', Asian Journal of Organic Chemistry, 3, (11) pp. 1193-1196. ISSN 2193-5807 (2014) [Refereed Article]

DOI: 10.1002/ajoc.201402105 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Deans RM; Gardiner MG; Horne J; Hung AC; Hyland CJT; Just J

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2014Howard JK, Amin C, Lainhart B, Smith JA, Rimington J, et al., 'Synthesis of nitrogen-substituted methylenecyclopropanes by strain-driven overman rearrangement of cyclopropenylmethyl trichloroacetimidates', The Journal of Organic Chemistry, 79, (17) pp. 8462-8468. ISSN 0022-3263 (2014) [Refereed Article]

DOI: 10.1021/jo501423u [eCite] [Details]

Citations: Scopus - 13Web of Science - 12

Co-authors: Howard JK

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2013Amos RIJ, Gourlay BS, Yates BF, Schiesser CH, Lewis TW, et al., 'Mechanistic investigation of the oxidation of hydrazides: implications for the activation of the TB drug isoniazid', Organic and Biomolecular Chemistry, 11, (1) pp. 170-176. ISSN 1477-0520 (2013) [Refereed Article]

DOI: 10.1039/c2ob26419f [eCite] [Details]

Citations: Scopus - 11Web of Science - 10

Co-authors: Amos RIJ; Gourlay BS; Yates BF; Lewis TW

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2013Ferrins L, Rahmani R, Sykes ML, Jones AJ, Avery VM, et al., '3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis', European Journal of Medicinal Chemistry, 66 pp. 450-465. ISSN 0223-5234 (2013) [Refereed Article]

DOI: 10.1016/j.ejmech.2013.05.007 [eCite] [Details]

Citations: Scopus - 20Web of Science - 20

Co-authors: Hyland C

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2013Howard JK, Hyland CJT, Just J, Smith JA, 'Controlled oxidation of pyrroles: synthesis of highly functionalized γ-lactams', Organic Letters, 15, (7) pp. 1714-1717. ISSN 1523-7060 (2013) [Refereed Article]

DOI: 10.1021/ol400491p [eCite] [Details]

Citations: Scopus - 18Web of Science - 17

Co-authors: Howard JK; Hyland CJT; Just J

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2012Ross JJ, Tivendale ND, Davidson SE, Reid JB, Davies NW, et al., 'A mutation affecting the synthesis of 4-chloroindole-3-acetic acid', Plant Signalling & Behavior, 7, (12) pp. 1533-1536. ISSN 1559-2316 (2012) [Refereed Article]

DOI: 10.4161/psb.22319 [eCite] [Details]

Citations: Scopus - 1

Co-authors: Ross JJ; Tivendale ND; Davidson SE; Reid JB; Davies NW; Quittenden LJ

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2012Tivendale ND, Davidson SE, Davies NW, Smith JA, Dalmais M, et al., 'Biosynthesis of the halogenated auxin, 4-chloroindole-3-acetic acid', Plant Physiology, 159, (3) pp. 1055-1063. ISSN 0032-0889 (2012) [Refereed Article]

DOI: 10.1104/pp.112.198457 [eCite] [Details]

Citations: Scopus - 37Web of Science - 37

Co-authors: Tivendale ND; Davidson SE; Davies NW; Quittenden LJ; Sutton L; Bala RK; Horne J; Reid JB; Ross JJ

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2011Amos RIJ, Smith JA, Yates BF, Schiesser CH, 'Acyl radical addition to benzene and related systems - a computational study', Tetrahedron, 66, (38) pp. 7600-7604. ISSN 0040-4020 (2011) [Refereed Article]

DOI: 10.1016/j.tet.2010.07.041 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Amos RIJ; Yates BF

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2011Deverell JA, Rodemann T, Smith JA, Canty AJ, Guijt RM, 'UV initiated formation of polymer monoliths in glass and polymer microreactors', Sensors and Actuators B, 155, (1) pp. 388-396. ISSN 0925-4005 (2011) [Refereed Article]

DOI: 10.1016/j.snb.2010.11.020 [eCite] [Details]

Citations: Scopus - 29Web of Science - 28

Co-authors: Deverell JA; Rodemann T; Canty AJ; Guijt RM

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2011You HT, Grosse AC, Howard JK, Hyland CJT, Just J, et al., 'Chemoselective reduction of 2-acyl-N-sulfonylpyrroles: Synthesis of 3-pyrrolines and 2-alkylpyrroles', Organic & Biomolecular Chemistry, 9, (10) pp. 3948-3953. ISSN 1477-0520 (2011) [Refereed Article]

DOI: 10.1039/c1ob05111c [eCite] [Details]

Citations: Scopus - 11Web of Science - 10

Co-authors: Grosse AC; Howard JK; Hyland CJT; Just J; Molesworth PP

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2010Davies NW, Smith JA, Molesworth PP, Ross JJ, 'Hydrogen/deuterium exchange on aromatic rings during atmospheric pressure chemical ionization mass spectrometry ', Rapid Communications in Mass Spectrometry, 24, (7) pp. 1105-1110. ISSN 1097-0231 (2010) [Refereed Article]

DOI: 10.1002/rcm.4488 [eCite] [Details]

Citations: Scopus - 21Web of Science - 22

Co-authors: Davies NW; Molesworth PP; Ross JJ

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2010Kazarian AA, Smith JA, Hilder EF, Breadmore MC, Quirino JP, et al., 'Development of a novel fluorescent tag O-2-[aminoethyl]fluorescein for the electrophoretic separation of oligosaccharides ', Analytica Chimica Acta, 662, (2) pp. 206-213. ISSN 0003-2670 (2010) [Refereed Article]

DOI: 10.1016/j.aca.2010.01.011 [eCite] [Details]

Citations: Scopus - 12Web of Science - 10

Co-authors: Kazarian AA; Hilder EF; Breadmore MC; Quirino JP; Suttil J

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2010Molesworth PP, Gardiner MG, Jones R, Smith J, Tegg RS, et al., 'Synthesis and phytotoxicity of structural analogues of thaxtomin natural products', Australian Journal of Chemistry, 63, (5) pp. 813-820. ISSN 0004-9425 (2010) [Refereed Article]

DOI: 10.1071/CH10006 [eCite] [Details]

Citations: Scopus - 16Web of Science - 15

Co-authors: Molesworth PP; Gardiner MG; Jones R; Tegg RS; Wilson CR

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2010Tivendale ND, Davies NW, Molesworth PP, Davidson SE, Smith JA, et al., 'Reassessing the role of N-Hydroxytryptamine in auxin biosynthesis', Plant Physiology, 154, (4) pp. 1957-1965. ISSN 0032-0889 (2010) [Refereed Article]

DOI: 10.1104/pp.110.165803 [eCite] [Details]

Citations: Scopus - 48Web of Science - 45

Co-authors: Tivendale ND; Davies NW; Molesworth PP; Davidson SE; Lowe EK; Reid JB; Ross JJ

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2009Amos RIJ, Schiesser CH, Smith Jason, Yates BF, 'Nucleophilic Acyl Substitution of Acyl Diimides', Journal of Organic Chemistry, 74, (15) pp. 5707-5710. ISSN 0022-3263 (2009) [Refereed Article]

DOI: 10.1021/jo900923m [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Amos RIJ; Yates BF

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2009Amos RIJ, Smith Jason, Yates BF, Schiesser CH, 'Acyl radical addition to pyridine: multiorbital interactions', Tetrahedron, 65, (36) pp. 7653-7657. ISSN 0040-4020 (2009) [Refereed Article]

DOI: 10.1016/j.tet.2009.06.102 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Amos RIJ; Yates BF

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2009Goemann A, Deverell JA, Munting KF, Jones Roderick, Rodemann T, et al., 'Palladium-mediated organic synthesis using porous polymer monolith formed in situ as a continuous catalyst support structure for application in microfluidic devices', Tetrahedron, 65, (7) pp. 1450-1454. ISSN 0040-4020 (2009) [Refereed Article]

DOI: 10.1016/j.tet.2008.12.007 [eCite] [Details]

Citations: Scopus - 69Web of Science - 68

Co-authors: Goemann A; Deverell JA; Munting KF; Jones Roderick; Rodemann T; Canty AJ; Guijt RM

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2009Jones RC, Canty AJ, Deverell JA, Gardiner MG, Guijt RM, et al., 'Supported Palladium Catalysis Using a Heteroleptic 2-Methylthiomethylpyridine -N,S- Donor Motif for Mizoroki-Heck and Suzuki-Miyaura Coupling, Including Continuous Organic Monolith in Capillary Microscale Flow-Through Mode', Tetrahedron, 65, (36) pp. 7474-7481. ISSN 0040-4020 (2009) [Refereed Article]

DOI: 10.1016/j.tet.2009.07.013 [eCite] [Details]

Citations: Scopus - 35Web of Science - 36

Co-authors: Jones RC; Canty AJ; Deverell JA; Gardiner MG; Guijt RM; Rodemann T; Tolhurst V

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2009Quittenden LJ, Davies NW, Smith Jason, Molesworth PP, Tivendale N, et al., 'Auxin Biosynthesis in Pea: Characterization of the Tryptamine Pathway', Plant Physiology, 151, (3) pp. 1130-1138. ISSN 0032-0889 (2009) [Refereed Article]

DOI: 10.1104/pp.109.141507 [eCite] [Details]

Citations: Scopus - 56Web of Science - 54

Co-authors: Quittenden LJ; Davies NW; Molesworth PP; Tivendale N; Ross JJ

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2009Walker PW, Allen GR, Davies NW, Smith Jason, Molesworth PP, et al., 'Identification, Synthesis and Field Testing of (3Z,6Z,9Z)-3,6,9-Henicosatriene, a Second Bioactive Component of the Sex Pheromone of the Autumn Gum Moth, Mnesampela privata', Journal of Chemical Ecology, 35, (12) pp. 1411-1422. ISSN 0098-0331 (2009) [Refereed Article]

DOI: 10.1007/s10886-009-9717-2 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Walker PW; Allen GR; Davies NW; Molesworth PP

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2008Amos RIJ, Gourlay BS, Schiesser CH, Smith Jason, Yates BF, 'A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid', Chemical Communications, 2008, (14) pp. 1695-1697. ISSN 1359-7345 (2008) [Refereed Article]

DOI: 10.1039/b719570b [eCite] [Details]

Citations: Scopus - 30Web of Science - 27

Co-authors: Amos RIJ; Gourlay BS; Yates BF

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2008Canty AJ, Deverell JA, Goemann A, Guijt RM, Rodemann T, et al., 'Microfluidic devices for flow-through supported palladium catalysis on porous organic monolith', Australian Journal of Chemistry, 61, (8) pp. 630-633. ISSN 0004-9425 (2008) [Refereed Article]

DOI: 10.1071/CH08160 [eCite] [Details]

Citations: Scopus - 14Web of Science - 13

Co-authors: Canty AJ; Deverell JA; Goemann A; Guijt RM; Rodemann T

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2008Gourlay BS, Ryan JH, Smith Jason, 'Knorr-Rabe partial reduction of pyrroles: Application to the synthesis of indolizidine alkaloids', Beilstein Journal of Organic Chemistry, 4, (3) EJ ISSN 1860-5397 (2008) [Refereed Article]

DOI: 10.1186/1860-5397-4-3 [eCite] [Details]

Citations: Scopus - 8Web of Science - 12

Co-authors: Gourlay BS

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2007Gardiner MG, Jones RC, Mason CM, Smith JA, Wise LE, '(RS)-2-(3,4-Methylenedioxyphenyl)-5-phenyl-3,6-dihydro-2H-pyran', Acta Crystallographica Section E, 63, (2) pp. O955-O957. ISSN 1600-5368 (2007) [Refereed Article]

DOI: 10.1107/S1600536807003194 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Gardiner MG; Jones RC; Mason CM; Wise LE

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2007Gardiner MG, Jones RC, Ng M, Smith JA, 'Methyl 4-chloro-3,5-di-p-tolyl-1H-pyrrole-2-carboxylate dichloromethane hemisolvate', Acta Crystallographica Section E, 63, (1) pp. O197-O199. ISSN 1600-5368 (2007) [Refereed Article]

DOI: 10.1107/S1600536806052202 [eCite] [Details]

Co-authors: Gardiner MG; Jones RC; Ng M

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2007Gardiner MG, Jones RC, Ng M, Smith JA, 'Methyl 4-p-tolyl-1H-pyrrole-2-carboxylate', Acta Crystallographica Section E, 63, (2) pp. O470-O471. ISSN 1600-5368 (2007) [Refereed Article]

DOI: 10.1107/S1600536806055103 [eCite] [Details]

Citations: Scopus - 16Web of Science - 15

Co-authors: Gardiner MG; Jones RC; Ng M

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2006Banwell MG, Goodwin TE, Ng M, Smith JA, Wong DJ, 'Palladium-Catalysed Cross-Coupling and Related Reactions Involving Pyrroles', European Journal of Organic Chemistry, 2006, (14) pp. 3043-3060. ISSN 1434-193X (2006) [Refereed Article]

DOI: 10.1002/ejoc.200500911 [eCite] [Details]

Citations: Scopus - 86Web of Science - 85

Co-authors: Ng M

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2006Bolton K, Canty AJ, Deverell JA, Guijt RM, Hilder EF, et al., 'Macroporous monolith supports for continuous flow capillary microreactors', Tetrahedron Letters, 47, (52) pp. 9321-9324. ISSN 0040-4039 (2006) [Refereed Article]

DOI: 10.1016/j.tetlet.2006.10.113 [eCite] [Details]

Citations: Scopus - 41Web of Science - 37

Co-authors: Bolton K; Canty AJ; Deverell JA; Guijt RM; Hilder EF; Rodemann T

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2006Gourlay BS, Little I, Ryan JH, Smith JA, 'A General and Efficient Approach to the Proposed Structures of Frog Toxins: The 5-Alkylindolizidines', Natural Product Communications, 1, (10) pp. 831-837. ISSN 1934-578X (2006) [Refereed Article]

[eCite] [Details]

Citations: Scopus - 5Web of Science - 4

Co-authors: Gourlay BS; Little I

2006Gourlay BS, Molesworth PP, Ryan JH, Smith JA, 'A new and high yielding synthesis of unstable pyrroles via a modified Clauson-Kaas reaction', Tetrahedron Letters, 47, (5) pp. 799-801. ISSN 0040-4039 (2006) [Refereed Article]

DOI: 10.1016/j.tetlet.2005.11.104 [eCite] [Details]

Citations: Scopus - 37Web of Science - 38

Co-authors: Gourlay BS; Molesworth PP

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2006Hutchinson J, Hilder EF, Shellie RA, Smith JA, Haddad PR, 'Towards high capacity latex-coated porous polymer monoliths as ion-exchange stationary phases', Analyst, 131, (2) pp. 215-221. ISSN 0003-2654 (2006) [Refereed Article]

DOI: 10.1039/b511398a [eCite] [Details]

Citations: Scopus - 77Web of Science - 75

Co-authors: Hutchinson J; Hilder EF; Shellie RA; Haddad PR

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2006Smith JA, Ng M, White J, 'The regioselective synthesis of aryl pyrroles', Organic and Biomolecular Chemistry, 4, (12) pp. 2477-2482. ISSN 1477-0520 (2006) [Refereed Article]

DOI: 10.1039/b604692d [eCite] [Details]

Citations: Scopus - 36Web of Science - 38

Co-authors: Ng M

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2005Amos RIJ, Gourlay BS, Molesworth PP, Smith JA, Sprod OR, 'Annulation of pyrrole: application to the synthesis of indolizidine alkaloids', Tetrahedron, 61, (34) pp. 8226-8230. ISSN 0040-4020 (2005) [Refereed Article]

DOI: 10.1016/j.tet.2005.06.026 [eCite] [Details]

Citations: Scopus - 55Web of Science - 50

Co-authors: Amos RIJ; Gourlay BS; Molesworth PP; Sprod OR

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2003Banwell MG, Edwards AJ, Jolliffe KA, Smith JA, Hamel E, et al., 'Total synthesis of (±)-rhazinal, an alkaloid spindle toxin from Kopsia teoi', Organic and Biomolecular Chemistry, 1, (2) pp. 296-305. ISSN 1477-0520 (2003) [Refereed Article]

DOI: 10.1039/b209992f [eCite] [Details]

Citations: Scopus - 65Web of Science - 65

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2002Banwell MG, Coster MJ, Karunaratne OP, Smith JA, 'A chemoenzymatic synthesis of the styryllactone (+)-goniodiol', Royal Society of Chemistry, Perkin Transactions I, (14) pp. 1622-1624. ISSN 1470-4358 (2002) [Refereed Article]

DOI: 10.1039/b205230j [eCite] [Details]

Citations: Web of Science - 19

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2002Banwell MG, Smith JA, 'Exploiting multiple nucleophilic sites on pyrrole for the assembly of polyheterocyclic frameworks: application to a formal total synthesis of (+/-)-aspidospermidine', Journal of the Chemical Society, Perkins Transactions I, (23) pp. 2613-1618. ISSN 1470-4358 (2002) [Refereed Article]

DOI: 10.1039/b208821e [eCite] [Details]

Citations: Web of Science - 36

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2001Banwell MG, Smith JA, 'A mild one-pot method for the conversion of carboxylic acids into the corresponding weinreb amides', Synthetic Communications, 31, (13) pp. 2011-2019. ISSN 0039-7911 (2001) [Refereed Article]

DOI: 10.1081/SCC-100104418 [eCite] [Details]

Citations: Scopus - 25Web of Science - 23

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2000Banwell MG, Edwards AJ, Smith JA, Hamel E, Verdier-Pinard P, 'Convergent synthesis and preliminary biological evaluation of (+/-)-B-norrhazinal', Journal of the Royal Society of Chemistry, Perkin Transactions I, (10) pp. 1497-1499. ISSN 1470-4358 (2000) [Refereed Article]

DOI: 10.1039/b001731k [eCite] [Details]

Citations: Web of Science - 22

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Chapter in Book

(9 outputs)
YearCitationAltmetrics
2017Meyer AG, Bissember AC, Hyland C, Smith JA, Williams CC, et al., 'Chapter 7: Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier Ltd., GW Gribble, JA Joule (ed), Netherlands, pp. 579-633. ISBN 9780081023105 (2017) [Research Book Chapter]

DOI: 10.1016/B978-0-08-102310-5.00016-3 [eCite] [Details]

Citations: Scopus - 4

Co-authors: Bissember AC; Abel SAG

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2016Meyer AG, Smith JA, Hyland C, Williams CC, Bissember AC, et al., 'Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier, GW Gribble & JA Joule (ed), Amsterdam, Netherlands, pp. 579-622. ISBN 9780081007556 (2016) [Research Book Chapter]

DOI: 10.1016/B978-0-08-100755-6.00016-8 [eCite] [Details]

Citations: Scopus - 4

Co-authors: Bissember AC; Nicholls TP

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2015Ryan JH, Smith JA, Hyland C, Meyer AG, Williams CC, et al., 'Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier, GW Gribble, JA Joule (ed), Amsterdam, The Netherlands, pp. 531-573. ISBN 978-0-08-100024-3 (2015) [Research Book Chapter]

DOI: 10.1016/B978-0-08-100024-3.00016-7 [eCite] [Details]

Citations: Scopus - 7

Co-authors: Bissember AC; Just J

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2014Ryan JH, Smith JA, Hyland C, Meyer AG, Williams CC, et al., 'Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier, GW Gribble, JA Joule (ed), Amsterdam, The Netherlands, pp. 521-571. ISBN 978-0-08-100017-5 (2014) [Research Book Chapter]

DOI: 10.1016/B978-0-08-100017-5.00016-9 [eCite] [Details]

Citations: Scopus - 4

Co-authors: Bissember AC; Just J

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2013Ryan JH, Hyland C, Just J, Meyer AG, Smith JA, et al., 'Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier, GW Gribble, JA Joule (ed), Oxford, United Kingdom, pp. 455-497. ISBN 978-0-08-099406-2 (2013) [Research Book Chapter]

DOI: 10.1016/B978-0-08-099406-2.00017-0 [eCite] [Details]

Citations: Scopus - 11

Co-authors: Just J

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2012Ryan JH, Hyland C, Meyer AG, Smith JA, Yin J, 'Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier, GW Gribble, JA Joule (ed), Oxford, United Kingdom, pp. 493-536. ISBN 978-0-08-096807-0 (2012) [Research Book Chapter]

DOI: 10.1016/B978-0-08-096807-0.00016-6 [eCite] [Details]

Citations: Scopus - 18

Co-authors: Hyland C

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2011Smith JA, Molesworth PP, Hyland CJT, Ryan JH, 'Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier, GW Gribble, JA Joule (ed), Amsterdam, pp. 491-536. ISBN 978-0-08-096685-4 (2011) [Research Book Chapter]

[eCite] [Details]

Co-authors: Molesworth PP; Hyland CJT

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2009Smith Jason, Molesworth PP, Ryan JH, 'Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier, G.W. Gribble and J.A. Joule (ed), Amsterdam, pp. 491-530. ISBN 978-0-08-096515-4 (2009) [Research Book Chapter]

DOI: 10.1016/S0959-6380(09)70044-3 [eCite] [Details]

Citations: Scopus - 14

Co-authors: Molesworth PP

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2009Smith Jason, Ryan JH, 'Seven-Membered Rings', Progress in Heterocyclic Chemistry, Elsevier, G.W. Gribble and J.A. Joule (ed), Amsterdam, pp. 432-458. ISBN 978-0-08-046975-1 (2009) [Research Book Chapter]

DOI: 10.1016/S0959-6380(09)70021-2 [eCite] [Details]

Citations: Scopus - 5

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Conference Publication

(5 outputs)
YearCitationAltmetrics
2009Davies NW, Walker PW, Allen GR, Smith Jason, Molesworth PP, et al., 'The Autumn Gum Moth sex pheromone - an elusive blend of alkatrienes', Proceedings of the 22nd Conference of the Australian and New Zealand Society for Mass Spectrometry ( ANZSMS22), 27-30 January 2008, Sydney Conservatorium of Music, Sydney, Australia (2009) [Conference Extract]

[eCite] [Details]

Co-authors: Davies NW; Walker PW; Allen GR; Molesworth PP

2008Canty AJ, Deverell JA, Gardiner MG, Goemann A, Guijt RM, et al., 'Miniaturising Metal Catalysis at the Micrometre Level in Capillaries and Glass Chips', IC08: Royal Australian Chemical Institute Conference of the Inorganic Division Programme and Books of Abstracts, 14-18 December 2008, University of Canterbury, Christchurch New Zealand, pp. 49. (2008) [Conference Extract]

[eCite] [Details]

Co-authors: Canty AJ; Deverell JA; Gardiner MG; Goemann A; Guijt RM; Jones Roderick; Rodemann T; Tolhurst V

2008Canty AJ, Deverell JA, Gardiner MG, Goemann A, Guijt RM, et al., 'Miniaturising organic monolith supported metal catalysis at the sub-micrometre level in capillaries and glass chip', 4th EuCheMS Conference on Nitrogen Ligands in Coordination Chemistry, Metal-Organic Chemistry, Bioinorganic Chemistry and Homogeneous Catalysis Program and Book of Abstracts, 24-28 August 2008, Garmisch-Partenkirchen, Germany, pp. 64. (2008) [Conference Extract]

[eCite] [Details]

Co-authors: Canty AJ; Deverell JA; Gardiner MG; Goemann A; Guijt RM; Jones Roderick; Rodemann T; Tolhurst V

2007Bolton KF, Canty AJ, Deverell JA, Guijt RM, Hilder EF, et al., 'Capillary Microreactor Catalysis Utilising Solid Organic Macroporous Monolith Supports', IC07: Royal Australian Chemical Institute Conference of the Inorganic Division Program and Conference Papers, 4-8 Feb 2007, Wrest Point Convention Centre, Hobart, pp. Poster 204. (2007) [Conference Extract]

[eCite] [Details]

Co-authors: Bolton KF; Canty AJ; Deverell JA; Guijt RM; Hilder EF; Rodemann T; Goemann A

2007Quittenden LJ, Davies NW, Smith JasonAlfred, Symons GM, Ross JJ, 'A compound-based approach to unraveling auxin biosynthesis in pea', The International Plant Growth Substances Association 19th Conference, Book of Abstracts, July 21-25, 2007, Puerto Vallarta, Mexico . (2007) [Conference Extract]

[eCite] [Details]

Co-authors: Quittenden LJ; Davies NW; Symons GM; Ross JJ

Other Public Output

(1 outputs)
YearCitationAltmetrics
2018Desire CT, Deans R, Shellie RA, Smith JA, Bissember AC, 'Oranges, lemons and limonene: addressing surprisingly persistent and enduring myths', Chemistry in Australia, Royal Australian Chemical Institute, Australia, February 2018, p. 35. (2018) [Magazine Article]

[eCite] [Details]

Co-authors: Desire CT; Deans R; Shellie RA; Bissember AC

Grants & Funding

Funding Summary

Number of grants

24

Total funding

$2,594,329

Projects

Pre-clinical toxicity assessment to select drug development candidates against mitochondrial dysfunction (2020 - 2021)$144,300
Description
This application supports a valley of death project to generate the pre-clinical toxicity data that are required towards commercialisation of UTAS-derived novel drug candidates
Funding
National Foundation for Medical Research and Innovation ($144,300)
Scheme
Grant-Expression of Interest
Administered By
University of Tasmania
Research Team
Guven N; Smith JA; Ambrose M
Period
2020 - 2021
HDAC6 inhibition to rescue axon degeneration in ALS (2019 - 2022)$997,046
Description
We will test an HDAC6 inhibitor in models of ALS. We will investigate the HDA6 inhibitor activity of novel compounds
Funding
FightMND ($997,046)
Scheme
Grant - Drug Development Grant
Administered By
University of Tasmania
Research Team
King AE; Cook AL; Guven N; Van Den Bosch L; Dickson TC; Blizzard C; Vickers JC; Smith JA; Alty JE; Leung JY; Perry SE
Period
2019 - 2022
Isolation and synthesis of potential new therapeutic agents from Hemp (Cannabis sativa) and their biological evaluation (2018 - 2021)$105,000
Description
Cannabis and cannabis extracts have been reported to have beneficial applications to many indications including the management of seizures, pain, cancer and appetite amongst others. One problem has been the illicit nature of the material which results in lack of control of the dose and chemical profile of material which can be due to different plant varieties, growing conditions, extraction preparation and mode of delivery. This project aims to adopt a drug discovery approach to provide solid evidence for the effect of different cannabinoids by isolating the individual components for thorough evaluation of any therapeutical applications. In this way, clear dose dependant activity can be studied and protocols for the prescription of cannabinoids can be developed that are in-line with modern pharmaceutical procedures. This will also be the start point for the development of novel semi-synthetic cannabinoids that will allow us to develop structure activity relationships for different indications. This potentially extends the scope of the medicinal cannabis industry to be a raw material for the synthesis of active non-natural derivates similar to the semi-synthetic opiates.
Funding
Martha Jane Medical ($105,000)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Smith JA; Jacobson GA; Guven N; Bissember AC
Period
2018 - 2021
Acoustic liquid handling robotics for bioactive compound discovery (2017)$315,000
Description
The proposal aims to incorporate enhanced robotic liquid handling capability into the workflow of CompoundsAustralia to further accelerate world-class research towards bioactive compound discovery. Compounds Australiaconnects Australias chemists with the global bioscience research community by making available the nationalcompound collection (>670,000 compounds) in assay-ready formats. The requested equipment will support anetwork of 38 research groups from 22 organisations (academic, not-for-profit and industry), across five states.The research projects we aim to support with this equipment are diverse, but share a common emphasis on novelbioactive compound discovery to advance the understanding of complex biological phenomena.
Funding
Australian Research Council ($315,000)
Scheme
Grant-Linkage Infrastructure
Administered By
Griffith University
Research Team
Poulsen SA; Martin J; Avery V; Quinn R; Baell J; Scanlon M; Booker G; Abell A; Wang S; Karuso P; Guillemin G; Smith JA
Year
2017
Grant Reference
LE170100075
Extraction and analysis of Plant Material (2016)$3,000
Description
Extraction of plant root and analysis of compounds. Root to be extracted using pressurised hot water extraction and the major components purified by flash chromatography and characterised.
Funding
ZoeticDevelopment Group Pty Ltd ($3,000)
Scheme
Consultancy
Administered By
University of Tasmania
Research Team
Smith JA; Bissember AC
Year
2016
Synthesis of Opiate Derivatives (2015)$20,000
Funding
Tasmanian Alkaloids Pty Ltd ($20,000)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Smith JA; Bissember AC
Year
2015
Chemika impurity characterisation - ICH guidelines (2014)$8,794
Description
This project will identify degradation products that arise during routine quality control assays as part of compliance with ICH guidelines. Degradation products will be identified using a three step process of UPLC with low resolution MS and fractionation and purity testing, followed by high resolution MS (orbitrap), with subsequent NMR.
Funding
Chemika Pty ltd ($8,794)
Scheme
Consultancy
Administered By
University of Tasmania
Research Team
Jacobson GA; Davies NW; Wilson RK; Horne HJ; Smith JA
Year
2014
Scientific opinion on Patent (2014)$17,826
Funding
Griffith Hack ($17,826)
Scheme
Consultancy
Administered By
University of Tasmania
Research Team
Smith JA
Year
2014
The role of plant hormones in legume symbioses (2014 - 2016)$436,000
Description
Soil microbes can give plants access to previously unavailable but essential nutrients through symbioses. Legumes are unique as they form symbioses with both nitrogen-fixing bacteria and with mycorrhizal fungi that supply nutrients such as phosphate. This project will investigate the role of the plant hormones (small, mobile, potent growth regulators) in the formation of these symbiotic relationships across legume genera. An insight into the common and divergent roles of hormones in these symbioses is essential to provide researchers and breeders with new tools to maximise nutrient acquisition by legumes, important crops contributing an estimated A$1 billion/y to the Australian economy.
Funding
Australian Research Council ($436,000)
Scheme
Grant-Discovery Projects
Administered By
University of Tasmania
Research Team
Reid JB; Foo E; Davies NW; Smith JA
Period
2014 - 2016
Grant Reference
DP140101709
Neuroprotective function of novel short chain-quinones (2013)$9,090
Description
Most eye disorders are associated with mitochondrial dysfunction. Based on the mitochondria-protective drug idebenone, we will synthesize novel, improved neuroprotective compounds. These compounds will be tested in a microfluidics cell culture model of mechanical stress-induced neuro-degeneration to identify new treatments strategies against retinal degeneration.
Funding
Royal Hobart Hospital Research Foundation ($9,090)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
McCartney PJ; Guven N; Guijt RM; Smith JA
Year
2013
Beetle aggregation research (2012)$2,000
Funding
Hydro Tasmania ($2,000)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Allen GR; Quarrell SR; Davies NW; Smith JA
Year
2012
2012: International Conference on Organic Synthesis (ICOS 19), (2012)$700
Funding
University of Tasmania ($700)
Scheme
Grant-Conference Support Scheme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2012
Scientific Opinion on Patent (2011)$19,091
Funding
Houlihan2 ($19,091)
Scheme
Consultancy
Administered By
University of Tasmania
Research Team
Smith JA
Year
2011
June 2011: International Society of Heterocyclic Chemistry (2011)$2,497
Funding
University of Tasmania ($2,497)
Scheme
Grant-Conference Support Scheme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2011
New Methods for the Template Mediated Synthesis of Biologically Active Compounds (2009)$14,250
Funding
University of Tasmania ($14,250)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2009
Chemical Reactivity of Opiates and Synthesis of New Opiate Derivatives (2008 - 2010)$348,831
Funding
Tasmanian Alkaloids Pty Ltd ($348,831)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Smith JA
Period
2008 - 2010
Development of novel, host-directed antimalarial compounds (2008)$75,000
Funding
University of Tasmania ($75,000)
Scheme
Grant-Pre Seed
Administered By
University of Tasmania
Research Team
Foote SJ; Smith JA; McMorran BJ
Year
2008
Investigation into Synthetic Methods for the Synthesis of Biologically Active Molecules: Pyrrolidine and Proline Derivates (2007)$7,950
Funding
University of Tasmania ($7,950)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2007
The Development of New Antibiotics Targeted Towards Multi Drug Resistant Tuberculosis (2006)$12,000
Funding
University of Tasmania ($12,000)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2006
Microreactors for Organic Synthesis (2005)$15,000
Funding
University of Tasmania ($15,000)
Scheme
Grant-RCB Research Support Scheme
Administered By
University of Tasmania
Research Team
Rodemann T; Guijt RM; Smith JA
Year
2005
Synthesis of Standards for the Monitoring of Bioremediation of Hydrocarbon Fuels (2005)$1,000
Funding
Department of Environment and Energy (Cwth) ($1,000)
Scheme
Grant-Human Impacts Research Programme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2005
Investigating the Chemical Properties of Alkaloid components (2004)$7,500
Funding
Tasmanian Alkaloids Pty Ltd ($7,500)
Scheme
Consultancy
Administered By
University of Tasmania
Research Team
Smith JA
Year
2004
New Synthetic Technology for the Synthesis of Biologically Important Compounds (2004)$22,000
Funding
University of Tasmania ($22,000)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2004
Biomimetic Approach to the Synthesis of Alkaloids: Dinuclear Manganese Complexes as Mimics of Cytochrome P450 in Oxidative Phenolic Coupling (2002)$10,454
Funding
University of Tasmania ($10,454)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Smith JA
Year
2002

Research Supervision

Current

10

Completed

16

Current

DegreeTitleCommenced
PhDSynthesis and Functionalisation of Heterocyclic Molecules with Bioactive Properties2016
PhDHalogen Bonding for the Self Assembly of Helicates2016
PhDEfficient Synthesis of Complex Molecules2017
PhDDevelopment and Application of Multi-dimensional GC and GC-MS Techniques to the Investigation of the Content and Nature of Plant Extracts and Essential Oils2017
PhDSynthesis and Evaluation of New Compounds for Drug Discovery2017
PhDIsolation and Synthesis of Potential New Therapeutic Agents from Hemp (Cannabis sativa) and their Biological Evaluation2019
PhDDescriptors and Bioactivity of Leatherwood Honey: An iconic Australian honey bee product2019
MastersNatural Products Chemistry: investigating molecules with therapeutic potential and chemotaxonomic value, molecules found in the endemic plant species of Tasmania2019
PhDIsolation of Plant Secondary Metabolites of Taxonomic and Therapeutic Significance2020
PhDBioprospecting for Bioactive Compounds: Exploiting natures medicine chest2020

Completed

DegreeTitleCompleted
PhDApplications of Density Functional Theory (DFT) in Organic and Inorganic Reactions
Candidate: Ali Gouranourimi
2020
PhDSynthetic Approaches to Naturally Occurring Strigolactones and Selected Analogues
Candidate: Steven Alan Grant Abel
2020
PhDIsolation of Plant Natural Products of Potential Chemotaxonomic Significance and Medicinal Value
Candidate: Bianca Judith Deans
2019
PhDThe Mutagenic Activity of Oxazolopyridine Compounds
Candidate: Hsien Hooi Lee
2018
PhDDevelopment of a Novel Pressurised Hot Water Extraction Method and its Application in Natural Product Isolation and Synthesis
Candidate: Jeremy Just
2018
PhDApplications of the Controlled Oxidation of Pyrroles
Candidate: Kieran Josef Rihak
2018
PhDSynthesis of New Derivatives Targeting Mitochondrial Dysfunction
Candidate: Krystel Lee Woolley
2018
PhDChlorinated Auxin in the Fabaceae: Distribution, evolutionary origin and genetic aspects
Candidate: Hong Kiat Lam
2017
PhDAn Evaluation and Redevelopment of Current Laboratory Practices: An in-depth study into the differences between learning and teaching styles
Candidate: Reyne Pullen
2016
PhDNew Methods for the Synthesis of Nitrogen Containing, Biologically Relevant Small Molecules
Candidate: James Kenneth Howard
2015
MastersOxazolopyridines towards the Treatment of Human African Sleeping Sickness
Candidate: Basmah Mohammed K Almohaywi
2014
PhDThe Biosynthesis of Two Naturally-occurring Auxins in Pisum sativum L
Candidate: Nathan David Tivendale
2012
PhDA Study of the Physical Chemistry of Acyl Radicals - Formation and Reactions
Candidate: Ruth Irene Joan Amos
2010
PhDNew Synthetic Approaches to Indolizidine and Pyrrolidine Alkaloids
Candidate: Brendon Scott Gourlay
2010
PhDStudies on the Synthesis of Biologically Active, Small Molecule Natural Products
Candidate: Peter Patrick Molesworth
2010
PhDRegioselective Modification of Pyrroles - Applications Towards Lamellarins & Pyrrolidine Analogues
Candidate: Sarah Man Yee Ng
2010