Profiles
Raj Eri
Raj Eri
Associate Professor, Laboratory Medicine and Human Bioscience
Room 115 , C
Dr Eri was awarded a PhD in molecular biology by the University of Queensland in 2001 and continued to be a post-doc/senior scientist both in Australia and USA in the area of gut inflammation and immunology. In December 2010, he joined the University of Tasmania and established his independent group investigating topics in mucosal biology, establishing a national, and an emerging international, reputation in this area. Dr Eri also coordinates and teaches in the fields of immunology and biochemistry. Dr Eri's specific expertise includes simulation - to create virtual laboratories, technology enhanced learning, teaching-research nexus.
Dr Eri's research interests include the role of inflammasomes on bowel diseases and bowel cancer, early stage carcinogenesis pathways in colorectal cancer and the role of cytokines in inflammatory bowel disease (IBD) pathogenesis. His current research projects include inflammasomes in IBD, CCR6 in IBD pathogenesis, colorectal cancer pathways, heparin as anti-inflammatory agent in colitis, the role of bitter melon as anti-ER stress agent, and epidemiology of IBD in Tasmania.
Biography
CIA Eri (DVM, PhD) is a veterinarian turned biomedical scientist with an emerging international reputation in the field of mucosal biology/immunology. His research interests include understanding the role of inflammasomes, chemokines (CCR6 and CCL20), IL-23/TH17 pathways in both murine and human IBD. Additionally, Dr Eri conducts research into the efficacy of natural products (bitter melon, raw banana, yogurt) in the treatment of IBD and a number pf pre-clinical studies are being carried in that direction.
His recent research interests include colorectal cancer and respiratory diseases such as asthma and COPD. Previously he was a senior research officer at the Mater Medical Research Institute (MMRI, now TRI, Brisbane). During this time he was chief investigator on 3 NHMRC and 1 Queensland Cancer Fund applications and was instrumental in providing ground breaking identification of ER stress in the pathogenesis of IBD. His PhD was awarded in 2001 from the University of Queensland and the initial post-doctoral work in mucosal immunology area was conducted in UCLA, USA. Since 2011, Dr Eri has established an independent laboratory at UTAS. Even as a 40:40:20 academic at UTAS, he has maintained a very productive research career as evidenced from publications (20), grants (6) and graduate students (5) during that period. The collective impact of CIA Eri's contribution is highlighted by numerous worldwide collaborations with clinicians and researchers, invitations to speak at international meetings, invited reviews, as well as editorial and refereeing work. To cite a few examples, he was invited to edit an edition of Frontiers in Immunology, organised and chaired sessions at Gastroenterological Society of Australia (GESA) annual meetings, invited to speak at a number of conferences in Australia. He published in prestigious journals (PLoS medicine, J Exp Med, Gut, BMJ). His work is widely cited (a total of ~ 1500 citations) with an average of more than 26 citations/paper and more than 350 citations for the highest cited paper.
Career summary
Qualifications
- PhD, University of Queensland, Australia, 2001
- M V Sc, TN Veterinary and Animal Sciences University, India, 1994
- B V Sc, TN Veterinary and Animal Sciences University, India, 1990
- Grad Cert T&L, University of Tasmania, 2012
Languages (other than English)
- Hindi
- Tamil
- Esperanto
- Telugu
- Kannada
Memberships
Professional practice
- Australian Society for Medical Research (ASMR)- President-Tasmania: Three years of organizing Medical Research Week in Tasmania
- NHMRC grants assessor: NHMRC has requested to review project grants for 2010-13. So far, assessed 6 grants
- Manuscript Reviewer: 10 Journals including American Journal of Physiology (Gastro), Journal of Cellular Biochemistry, PLoS One etc.
- MMRI student committee member: specially in-charge of recruitment: Organised MMRI student open days and also attended recruitment expos at UQ, QUT to attract students
- MMRI seminar series coordinator: Arranged speakers every week for MMRI seminar series and coordinated the seminars- 2008
- MMRI science week committee member: Part of national science week celebrations educating students and public from various parts of Queensland through public lectures – 2008-09
- MMRI statistical task force member: Part of the committee that decides on statistical requirements for the institute
- ASMR Queensland Premier's Award Committee member: Organising member for the prestigious awards for the last 4 years
- Australasian Society for Immunology (ASI): Member for organising the national conference for 2009 at the Gold Coast
- Organising Committee member for ASI-FIMSA: an advanced course in immunology 2009
Administrative expertise
- Managed NHMRC research project as CIA
- Graduate research coordination
Teaching
Teaching expertise
Raj has a strong commitment to strategies that bridge research and teaching by incorporating research principles into classroom teaching. He has introduced adaptive eLearning methods to augment student skills for better learning outcomes. His determination to motivate students to be independent learners has proven his excellence in teaching as evidenced by SETL/eVALUate/feedback from students and peers.
Raj has also been involved in a number of educational research projects (including investigator in 3 TDGs) & published 4 papers so far. He has an active commitment to the Tasmanian community.
Teaching responsibility
- Biochemistry (CXA125)
- Immunology (MLS) (CXA211)
- Immunology (CXA321)
View more on AssocProf Raj Eri in WARP
Expertise
- Chronic Inflammation
- ER stress
- Pathogenesis of inflammatory Bowel Disease
- Gut Health
- Pre-clinical models of gut health
- Inflammasomes
Research Themes
Raj's research aligns to the University's research theme of Better Health. He has significant expertise in the fields of colitis and IBD that includes a multitude of animal models of colitis. Furthermore he was the first to describe the ER stress induced molecular pathology of a novel murine model of spontaneous colitis-Winnie. All the clinical, histological, immunological and immuno-histochemical methods have been optimised and being in current use in his research laboratory.
Overall, Raj has published over 25 papers and reviews in this specific field in high ranking journals in the areas of the role of ER stress, the pre-clinical efficacy of a number of food products/peptides/cytokines for the treatment of colitis.
Raj was specifically recruited to UTAS as a 'research active' academic. He has established a mucosal biology laboratory and already recruited many Honours/PhD students in his projects. He is trying to establish a niche for himself in the mucosal immunology area and is uniquely positioned as only one of a very few dedicated mucosal immunology researchers in Australia. His vision is to conduct high-quality research in the areas of chronic intestinal inflammation & colorectal cancer and contribute towards a better understanding of IBD pathogenesis and treatment. Furthermore, he would also like to conduct basic research in the area cell stress and apoptosis specifically in the intestinal epithelial cells. In addition to his science research, Raj has a keen interest in educational research as well. To this end, he currently holds a teaching development grant from UTAS.
Collaboration
- Prof Heinrich Korner - MRIT and University of Tasmania
- Assoc Prof Nuri Guven - School of Pharmacy, University of Tasmania
- Dr Rahul Patel - School of Pharmacy, University of Tasmania
- Dr Lana Shabala - School of Agriculture, University of Tasmania
- Dr Christine Booth - DSTO, Scottsdale
- Dr Kulmira Nurgali - Victoria University, Melbourne
- Drs Brent Mitchell, Scott Fanning, Ray Wilson - Launceston General Hospital
- Dr Prathiba Nerurkar - University of Hawaii, U.S.A.
- Dr Marcello Chieppa - Bari University, Italy
- Prof Mike McGuckin - Mater Medical Research Institute/TRI, University of Queensland, Brisbane
Awards
- Winner, rapid Research, UTAS, 2012
- Finalist, Queensland Premier's Award for Medical Research, Senior category, 2010
- UQ Reginald Ferguson fellowship in Gastroenterology Research, 2007
- UQ Reginald Ferguson fellowship in Gastroenterology Research, 2006
- Indiana University post-doctoral fellowship, USA, 2004
- Queensland Protein Group best oral presentation award, 2000
- Finalist, Young Investigator Award, Gastroenterology Week, Sydney, 2002
- QIMR cancer unit PhD scholarship, 1999
- Best Thesis Award - MVSc thesis - Veterinary Medicine, 1996
Current projects
- The hierarchial activation of inflammasomes in chronic colitis
Inflammasomes are protein complexes that are implicated in initiation of many diseases including inflammatory bowel disease (IBD). In my laboratory, we have characterised a mouse model that develops spontaneous colitis similar to human colitis. We have a strong indication from human studies that specific inflammasomes are activated in IBD. In this mouse model, we want to explore functional studies as to how inflammasome contributes to pathogenesis of IBD. - Characterisation of flat dysplasia in colitis associated colorectal cancer
Patients with ulcerative colitis are at increased risk of developing colorectal cancer. Colitis-associated colorectal cancer (CACC) progresses through similar stepwise gene mutations observed in sporadic cancers, but the sequence in which they occur is reversed. Understanding the transition from colitis to tumour requires relevant animal models. Colonic carcinogenesis has been modelled using genotoxic carcinogens such as azoxymethane. We hypothesise that exacerbation of pre-existing chronic colitis in a Muc2 mutant (Winnie) mouse strain with dextran sulphate sodium (DSS) would induce colorectal tumorigenesis. - CCR6 deficiency aggravates colitis in a spontaneous colitis model
Chemokine receptor 6 (CCR6) and its ligand CCL20 is implicated to play a major role in IBD pathogenesis. The CCR6/CCL20 axis is involved in both immune regulation and activation. CCR6 is expressed by both pro-inflammatory cells and regulatory T cells elucidate the dual role of the receptor. The contradictory role of CCR6/CCL20 in inflammation/homeostasis requires further research.
Fields of Research
- Genetic immunology (310507)
- Pharmaceutical sciences (321405)
- Gastroenterology and hepatology (320209)
- Cell development, proliferation and death (310102)
- Animal physiology - systems (310910)
- Cellular immunology (320404)
- Respiratory diseases (320103)
- Immunology (320499)
- Medical bacteriology (320701)
- Cell neurochemistry (310104)
- Nutritional science (321004)
- Pharmacology and pharmaceutical sciences (321499)
- Ophthalmology and optometry (321299)
- Innate immunity (320407)
- Nutrition and dietetics (321099)
- Higher education (390303)
- Signal transduction (310111)
- Cancer cell biology (321101)
- Cell metabolism (310103)
- Biochemistry and cell biology (310199)
- Central nervous system (320903)
- Metabolic medicine (320507)
- Rheumatology and arthritis (320223)
- Microbial ecology (310703)
- Community child health (420601)
- Mental health services (420313)
- Animal physiology - cell (310909)
- Solid tumours (321111)
- Chemotherapy (321105)
- Haematological tumours (321106)
- Food properties (incl. characteristics and health benefits) (321002)
- Haematology (320102)
- Clinical pharmacology and therapeutics (321402)
- Health and community services (420305)
- Science, technology and engineering curriculum and pedagogy (390113)
- Fine arts (360602)
- Bacteriology (310701)
- Bioprocessing, bioproduction and bioproducts (310602)
- Aboriginal and Torres Strait Islander public health and wellbeing (450417)
- Educational technology and computing (390405)
- Proteomics and metabolomics (310205)
- Education assessment and evaluation (390402)
- Occupational and workplace health and safety (350505)
- Vision science (321204)
- Infectious agents (310702)
- Health services and systems (420399)
- Cardiology (incl. cardiovascular diseases) (320101)
- Traditional, complementary and integrative medicine (420899)
- Medical biochemistry and metabolomics (320599)
- Receptors and membrane biology (310110)
- Clinical microbiology (320203)
- Psychiatry (incl. psychotherapy) (320221)
- Geriatrics and gerontology (320210)
- Animal physiology - biophysics (310908)
- Exercise physiology (420702)
- Epigenetics (incl. genome methylation and epigenomics) (310504)
- Genomics (310509)
- Genetics (310599)
- Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies) (320402)
- Traditional Chinese medicine and treatments (420803)
- Cellular nervous system (320902)
- Health promotion (420603)
- Behavioural neuroscience (520202)
- Visual arts (360699)
- Health care administration (420306)
- Human information interaction and retrieval (461003)
- Clinical pharmacy and pharmacy practice (321403)
- Clinical neuropsychology (520301)
- Health surveillance (420310)
- Sport and exercise nutrition (321006)
- Cognition (520401)
- Medical biochemistry - nucleic acids (320505)
- Cell physiology (320801)
- Sports science and exercise (420799)
- Food nutritional balance (300603)
- Pharmacogenomics (321406)
- Medical biotechnology (320699)
- Infectious diseases (320211)
- Cancer genetics (321103)
- Food engineering (400405)
- Tumour immunology (320409)
Research Objectives
- Clinical health (200199)
- Diagnosis of human diseases and conditions (200101)
- Expanding knowledge in the health sciences (280112)
- Treatment of human diseases and conditions (200105)
- Other health (209999)
- Prevention of human diseases and conditions (200104)
- Expanding knowledge in the biological sciences (280102)
- Public health (excl. specific population health) (200499)
- Human pharmaceutical treatments (240803)
- Human pharmaceutical products (240899)
- Disease distribution and transmission (incl. surveillance and response) (200404)
- Learner and learning (160199)
- Human biological preventatives (240801)
- Expanding knowledge in the biomedical and clinical sciences (280103)
- Health status (incl. wellbeing) (200407)
- Workforce transition and employment (160206)
- Expanding knowledge in the environmental sciences (280111)
- The creative arts (130103)
- Teaching and instruction technologies (160304)
- Efficacy of medications (200102)
- Mental health services (200305)
- Injury prevention and control (200408)
- Nursing (200307)
- Neonatal and child health (200506)
- Preventive medicine (200412)
- Plant extracts (241403)
- Other education and training (169999)
- Higher education (160102)
- Nutraceuticals and functional foods (241308)
- Personnel (140110)
- Social structure and health (200207)
- Expanding knowledge in psychology (280121)
- Health education and promotion (200203)
- Health inequalities (200204)
- Women's and maternal health (200509)
- Nutrition (200410)
- Emerging defence technologies (140104)
- Aboriginal and Torres Strait Islander determinants of health (210301)
Publications
The collective impact of CIA Eri's contribution is highlighted by numerous worldwide collaborations with clinicians and researchers, invitations to speak at international meetings, invited reviews, as well as editorial and refereeing work. To cite a few examples, he was invited to edit an edition of Frontiers in Immunology, organised and chaired sessions at Gastroenterological Society of Australia (GESA) annual meetings, invited to speak at a number of conferences in Australia. He published in prestigious journals (PLoS medicine, J Exp Med, Gut, BMJ). His work is widely cited (a total of ~ 1500 citations) with an average of more than 26 citations/paper and more than 350 citations for the highest cited paper.
Total publications
121
Highlighted publications
(7 outputs)| Year | Type | Citation | Altmetrics |
|---|---|---|---|
| 2015 | Journal Article | Wang R, Hasnain SZ, Tong H, Das I, Che-Hao Chen A, et al., 'Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model', Inflammatory Bowel Diseases, 21, (5) pp. 973-84. ISSN 1078-0998 (2015) [Refereed Article] DOI: 10.1097/MIB.0000000000000353 [eCite] [Details] Citations: Scopus - 24Web of Science - 23 | |
| 2014 | Journal Article | Alkadhi S, Kunde D, Cheluvappa R, Randall-Demllo S, Eri R, 'The murine appendiceal microbiome is altered in spontaneous colitis and its pathological progression', Gut pathogens, 6 Article 25. ISSN 1757-4749 (2014) [Refereed Article] DOI: 10.1186/1757-4749-6-25 [eCite] [Details] Citations: Scopus - 31Web of Science - 30 Co-authors: Kunde D; Randall-Demllo S | |
| 2013 | Journal Article | Das I, Png CW, Oancea I, Hasnain SZ, Lourie R, et al., 'Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins', The Journal of Experimental Medicine, 210, (6) pp. 1201-1216. ISSN 0022-1007 (2013) [Refereed Article] DOI: 10.1084/jem.20121268 [eCite] [Details] Citations: Scopus - 64Web of Science - 64 | |
| 2013 | Journal Article | Oancea I, Png CW, Das I, Lourie R, Winkler I, et al., 'A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity', Gut: An International Journal of Gastroenterology and Hepatology, 62, (4) pp. 594-605. ISSN 0017-5749 (2013) [Refereed Article] DOI: 10.1136/gutjnl-2012-302274 [eCite] [Details] Citations: Scopus - 42Web of Science - 42 | |
| 2008 | Journal Article | Eri RD, Heazlewood CK, Cook MC, Price GR, Tauro SB, et al., 'Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis', PLoS Med, 5, (3) pp. E54. ISSN 1549-1676 (2008) [Refereed Article] DOI: 10.1371/journal.pmed.0050054 [eCite] [Details] Citations: Scopus - 535Web of Science - 507 | |
| 2005 | Journal Article | Fukata M, Michelsen KS, Eri RD, Thomas LS, Hu B, et al., 'Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis', American Journal of Physiology: Gastrointestinal and Liver Physiology, 288, (5) pp. 1055-1065. ISSN 0193-1857 (2005) [Refereed Article] DOI: 10.1152/ajpgi.00328.2004 [eCite] [Details] Citations: Scopus - 418Web of Science - 381 | |
| 1999 | Journal Article | Eri RD, Arnold J, Hinman V, Green K, Jones M, et al., 'Hemps, a novel EGF-like protein plays a central role in ascidian metamorphosis', Development (Cambridge), 126, (24) pp. 5809-5818 . ISSN 0950-1991 (1999) [Refereed Article] Citations: Web of Science - 57 |
Journal Article
(94 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2021 | Ahmad T, Eapen MS, Ishaq M, Park AY, Karpiniec SS, et al., 'Anti-inflammatory activity of fucoidan extracts in vitro', Marine Drugs, 19, (12) Article 702. ISSN 1660-3397 (2021) [Refereed Article] DOI: 10.3390/md19120702 [eCite] [Details] Citations: Scopus - 8 Co-authors: Ahmad T; Eapen MS; Ishaq M; Sohal SS; Guven N; Caruso V | |
| 2021 | Chong WC, Chellappan DK, Shukla SD, Peterson GM, Patel RP, et al., 'An appraisal of the current scenario in vaccine research for COVID-19', Viruses, 13 pp. 1-18. ISSN 1999-4915 (2021) [Refereed Article] DOI: 10.3390/v13071397 [eCite] [Details] Citations: Scopus - 3Web of Science - 3 Co-authors: Shukla SD; Peterson GM; Patel RP; Shastri MD | |
| 2021 | De Santis S, Liso M, Vacca M, Verna G, Cavalcanti E, et al., 'Dysbiosis triggers ACF development in genetically predisposed subjects', Cancers, 13, (2) pp. 1-21. ISSN 2072-6694 (2021) [Refereed Article] DOI: 10.3390/cancers13020283 [eCite] [Details] Citations: Scopus - 5Web of Science - 5 | |
| 2021 | Eri R, Gudimetla P, Star S, Rowlands J, Girgla A, 'Digital resilience in higher education in response to COVID-19 pandemic: student perceptions from Asia and Australia', Journal of University Teaching and Learning Practice, 18, (5) Article 7. ISSN 1449-9789 (2021) [Refereed Article] Co-authors: Rowlands J; Girgla A | |
| 2021 | Gueven N, Ravishankar P, Eri RD, Rybalka E, 'Idebenone: when an antioxidant is not an antioxidant', Redox Biology, 38 Article 101812. ISSN 2213-2317 (2021) [Refereed Article] DOI: 10.1016/j.redox.2020.101812 [eCite] [Details] Citations: Scopus - 16Web of Science - 13 Co-authors: Gueven N; Ravishankar P | |
| 2021 | Ishaq M, Tran DT, Wu Y, Nowak K, Deans BJ, et al., 'Asperuloside enhances taste perception and prevents weight gain in high-fat fed mice', Frontiers in Endocrinology, 12 pp. 1-11. ISSN 1664-2392 (2021) [Refereed Article] DOI: 10.3389/fendo.2021.615446 [eCite] [Details] Citations: Scopus - 2Web of Science - 2 Co-authors: Ishaq M; Tran DT; Wu Y; Deans BJ; Southam B; Vicenzi S; Randall C; Yang C; Tan E; Ahmad T; Shastri M; Bleasel M; Scowen P; Jacobson G; Bissember AC; Smith JA; Canales J; Iglesias M; Guven N; Caruso V | |
| 2021 | Shastri S, Shinde TS, Woolley KL, Smith JA, Gueven N, et al., 'Short-chain naphthoquinone protects against both acute and spontaneous chronic murine colitis by alleviating inflammatory responses', Frontiers in Pharmacology, 12 pp. 1-16. ISSN 1663-9812 (2021) [Refereed Article] DOI: 10.3389/fphar.2021.709973 [eCite] [Details] Citations: Scopus - 1Web of Science - 1 Co-authors: Shinde TS; Woolley KL; Smith JA; Gueven N | |
| 2021 | Tran DT, Myers S, McGowan C, Henstridge D, Eri R, et al., '1-deoxysphingolipids, early predictors of type 2 diabetes, compromise the functionality of skeletal myoblasts', Frontiers in Endocrinology, 12 Article 772925. ISSN 1664-2392 (2021) [Refereed Article] DOI: 10.3389/fendo.2021.772925 [eCite] [Details] Citations: Scopus - 1 Co-authors: Tran DT; Myers S; McGowan C; Henstridge D; Sonda S; Caruso V | |
| 2020 | Beckett JM, Singh NK, Phillips J, Kalpurath K, Taylor K, et al., 'Anti-heartburn effects of sugar cane flour: A double-blind, randomized, placebo-controlled study', Nutrients, 12 pp. 1-9. ISSN 2072-6643 (2020) [Refereed Article] DOI: 10.3390/nu12061813 [eCite] [Details] Citations: Scopus - 1Web of Science - 1 Co-authors: Beckett JM; Singh NK; Stanley RA | |
| 2020 | Clarke LJ, Jones PJ, Ammitzboll H, Barmuta LA, Breed MF, et al., 'Mainstreaming microbes across biomes', Bioscience, 70, (7) pp. 589-596. ISSN 0006-3568 (2020) [Refereed Article] DOI: 10.1093/biosci/biaa057 [eCite] [Details] Citations: Scopus - 5Web of Science - 5 Co-authors: Clarke LJ; Jones PJ; Ammitzboll H; Barmuta LA; Charleston M; Dakwa V; Fountain-Jones NM; Kendal D; Sow SLS; Vemuri R; Flies EJ | |
| 2020 | Gundamaraju R, Lu W, Azimi I, Eri R, Sohal SS, 'Endogenous anti-cancer candidates in GPCR, ER stress, and EMT', Biomedicines, 8, (10) pp. 1-13. ISSN 2227-9059 (2020) [Refereed Article] DOI: 10.3390/biomedicines8100402 [eCite] [Details] Citations: Scopus - 5Web of Science - 5 Co-authors: Lu W; Azimi I; Sohal SS | |
| 2020 | Guven N, Spring KJ, Holmes S, Ahuja K, Eri R, et al., 'Micro RNA expression after ingestion of fucoidan; a clinical study', Marine Drugs, 18, (3) pp. 1-11. ISSN 1660-3397 (2020) [Refereed Article] DOI: 10.3390/md18030143 [eCite] [Details] Citations: Scopus - 9Web of Science - 8 Co-authors: Guven N; Holmes S; Ahuja K | |
| 2020 | Liso M, De Santis S, Verna G, Dicarlo M, Calasso M, et al., 'A specific mutation in Muc2 determines early dysbiosis in colitis-prone Winnie mice', Inflammatory Bowel Diseases, 26, (4) pp. 546-556. ISSN 1078-0998 (2020) [Refereed Article] DOI: 10.1093/ibd/izz279 [eCite] [Details] Citations: Scopus - 19Web of Science - 20 | |
| 2020 | Ngui IQH, Perera AP, Eri R, 'Does NLRP3 inflammasome and aryl hydrocarbon receptor play an interlinked role in bowel inflammation and colitis-associated colorectal cancer?', Molecules, 25, (10) pp. 1-25. ISSN 1420-3049 (2020) [Refereed Article] DOI: 10.3390/molecules25102427 [eCite] [Details] Citations: Scopus - 12Web of Science - 9 Co-authors: Perera AP | |
| 2020 | Ranasinghe R, Fernando R, Perera AP, Shastri M, Basheer W, et al., 'Ccr6 Deficiency attenuates spontaneous chronic colitis in Winnie', Gastrointestinal Disorders, 2 pp. 27-47. ISSN 2624-5647 (2020) [Refereed Article] DOI: 10.3390/gidisord2010004 [eCite] [Details] Co-authors: Perera AP; Shastri M; Basheer W; Scowen P; Pinfold T | |
| 2020 | Sahakian L, Filippone RT, Stavely R, Robinson AM, Yan XS, et al., 'Inhibition of APE1/Ref-1 redox signaling alleviates intestinal dysfunction and damage to myenteric neurons in a mouse model of spontaneous chronic colitis', Inflammatory Bowel Diseases, 27, (3) pp. 388-406. ISSN 1078-0998 (2020) [Refereed Article] DOI: 10.1093/ibd/izaa161 [eCite] [Details] Citations: Scopus - 7Web of Science - 7 | |
| 2020 | Shastri MD, Chong WC, Vemuri R, Martoni CJ, Adhikari S, et al., 'Streptococcus thermophilus UASt-09 upregulates goblet cell activity in colonic epithelial cells to a greater degree than other probiotic strains', Microorganisms, 8, (11) pp. 1-15. ISSN 2076-2607 (2020) [Refereed Article] DOI: 10.3390/microorganisms8111758 [eCite] [Details] Citations: Scopus - 3Web of Science - 2 Co-authors: Shastri MD; Chong WC; Vemuri R; Kunde D; Tristram SG | |
| 2020 | Shastri S, Shinde TS, Perera AP, Gueven N, Eri R, 'Idebenone protects against spontaneous chronic murine colitis by alleviating endoplasmic reticulum stress and inflammatory response', Biomedicines, 8, (10) Article 384. ISSN 2227-9059 (2020) [Refereed Article] DOI: 10.3390/biomedicines8100384 [eCite] [Details] Citations: Scopus - 5Web of Science - 4 Co-authors: Shinde TS; Perera AP; Gueven N | |
| 2020 | Shastri S, Shinde TS, Sohal SS, Gueven N, Eri R, 'Idebenone Protects against Acute Murine Colitis via Antioxidant and Anti-Inflammatory Mechanisms', International Journal of Molecular Sciences, 21, (2) pp. 1-21. ISSN 1422-0067 (2020) [Refereed Article] DOI: 10.3390/ijms21020484 [eCite] [Details] Citations: Scopus - 17Web of Science - 17 Co-authors: Shinde TS; Sohal SS; Gueven N | |
| 2020 | Shinde TS, Hansbro PM, Sohal SS, Dingle P, Eri R, et al., 'Microbiota modulating nutritional approaches to countering the effects of viral respiratory infections including SARS-CoV-2 through promoting metabolic and immune fitness with probiotics and plant bioactives', Microorganisms, 8, (6) Article 921. ISSN 2076-2607 (2020) [Refereed Article] DOI: 10.3390/microorganisms8060921 [eCite] [Details] Citations: Scopus - 37Web of Science - 35 Co-authors: Shinde TS; Sohal SS; Stanley R | |
| 2020 | Shinde TS, Perera AP, Vemuri R, Gondalia SV, Beale DJ, et al., 'Synbiotic supplementation with prebiotic green banana resistant starch and probiotic Bacillus coagulans spores ameliorates gut inflammation in mouse model of inflammatory bowel diseases', European Journal of Nutrition, 59, (8) pp. 3669-3689. ISSN 1436-6207 (2020) [Refereed Article] DOI: 10.1007/s00394-020-02200-9 [eCite] [Details] Citations: Scopus - 26Web of Science - 26 Co-authors: Shinde TS; Perera AP; Vemuri R; Basheer W; Southam B; Stanley R | |
| 2020 | Shinde TS, Vemuri R, Shastri Sonia, Perera AP, Gondalia SV, et al., 'Modulating the microbiome and immune responses using whole plant fibre in synbiotic combination with fibre-digesting probiotic attenuates chronic colonic inflammation in spontaneous colitic mice model of IBD', Nutrients, 12, (8) pp. 1-26. ISSN 2072-6643 (2020) [Refereed Article] DOI: 10.3390/nu12082380 [eCite] [Details] Citations: Scopus - 8Web of Science - 8 Co-authors: Shinde TS; Vemuri R; Perera AP; Stanley R | |
| 2020 | Vemuri R, Shankar EM, Chieppa M, Eri R, Kavanagh K, 'Beyond just bacteria: Functional biomes in the gut ecosystem including virome, mycobiome, archaeome and helminths', Microorganisms, 8, (4) pp. 1-24. ISSN 2076-2607 (2020) [Refereed Article] DOI: 10.3390/microorganisms8040483 [eCite] [Details] Citations: Scopus - 43Web of Science - 38 | |
| 2019 | Corban M, Ambrose M, Pagnon JC, Stringer D, Karpiniec S, et al., 'Pathway analysis of fucoidan activity using a yeast gene deletion library screen', Marine drugs, 17, (1) Article 54. ISSN 1660-3397 (2019) [Refereed Article] DOI: 10.3390/md17010054 [eCite] [Details] Citations: Scopus - 8Web of Science - 8 Co-authors: Corban M; Ambrose M; Pagnon JC; Fitton JH; Gueven N | |
| 2019 | Eri R, Gudimetla P, Vemuri R, 'Beyond the technical skills: a case for internationalization of graduate attributes in PhD programs', Universal Journal of Educational Research, 7, (3) pp. 766-771. ISSN 2332-3205 (2019) [Refereed Article] | |
| 2019 | Flies EJ, Mavoa S, Zosky GR, Mantzioris E, Williams C, et al., 'Urban-associated diseases: candidate diseases, environmental risk factors, and a path forward', Environment International, 133, (Part A) Article 105187. ISSN 0160-4120 (2019) [Refereed Article] DOI: 10.1016/j.envint.2019.105187 [eCite] [Details] Citations: Scopus - 48Web of Science - 41 Co-authors: Flies EJ; Zosky GR; Brook BW; Buettel JC | |
| 2019 | Gundamaraju R, Vemuri R, Chong WC, Bulmer AC, Eri R, 'Bilirubin attenuates ER Stress-Mediated Inflammation, escalates Apoptosis and reduces Proliferation in the LS174T Colonic Epithelial Cell Line', International journal of medical sciences, 16, (1) pp. 135-144. ISSN 1449-1907 (2019) [Refereed Article] DOI: 10.7150/ijms.29134 [eCite] [Details] Citations: Scopus - 12Web of Science - 12 Co-authors: Vemuri R; Chong WC | |
| 2019 | Ranson N, Veldhuis M, Mitchell B, Fanning S, Cook AL, et al., 'NLRP3-dependent and -independent processing of interleukin (IL)-1β in active ulcerative colitis', International Journal of Molecular Sciences, 20, (1) pp. 1-15. ISSN 1422-0067 (2019) [Refereed Article] DOI: 10.3390/ijms20010057 [eCite] [Details] Citations: Scopus - 37Web of Science - 36 Co-authors: Ranson N; Cook AL; Kunde D | |
| 2019 | Shinde TS, Perera AP, Vemuri R, Gondalia SV, Karpe AV, et al., 'Synbiotic supplementation containing whole plant sugar cane Fibre and probiotic spores potentiates protective synergistic effects in mouse model of IBD', Nutrients, 11, (4) Article 818. ISSN 2072-6643 (2019) [Refereed Article] DOI: 10.3390/nu11040818 [eCite] [Details] Citations: Scopus - 37Web of Science - 35 Co-authors: Shinde TS; Perera AP; Vemuri R; Shastri M; Southam BT; Stanley R | |
| 2019 | Shinde TS, Vemuri R, Shastri MD, Perera AP, Tristram S, et al., 'Probiotic Bacillus coagulans MTCC 5856 spores exhibit excellent in-vitro functional efficacy in simulated gastric survival, mucosal adhesion and immunomodulation', Journal of Functional Foods, 52 pp. 100-108. ISSN 1756-4646 (2019) [Refereed Article] DOI: 10.1016/j.jff.2018.10.031 [eCite] [Details] Citations: Scopus - 22Web of Science - 22 Co-authors: Shinde TS; Vemuri R; Shastri MD; Perera AP; Tristram S; Stanley R | |
| 2019 | Shukla SD, Shastri MD, Chong WC, Dua K, Budden KF, et al., 'Microbiome-focused asthma management strategies', Current Opinion in Pharmacology, 46 pp. 143-149. ISSN 1471-4892 (2019) [Refereed Article] DOI: 10.1016/j.coph.2019.06.003 [eCite] [Details] Citations: Scopus - 7Web of Science - 9 Co-authors: Shastri MD; Mahmood MQ; Patel RP; Peterson GM | |
| 2019 | Vemuri R, Gundamaraju R, Shinde TS, Perera AP, Basheer W, et al., 'Lactobacillus acidophilus DDS-1 modulates intestinal-specific microbiota, short-chain fatty acid and immunological profiles in aging mice', Nutrients, 11, (6) pp. 1-23. ISSN 2072-6643 (2019) [Refereed Article] DOI: 10.3390/nu11061297 [eCite] [Details] Citations: Scopus - 34Web of Science - 31 Co-authors: Vemuri R; Shinde TS; Perera AP; Basheer W; Southam B; Tristram S; Ahuja KDK | |
| 2019 | Wilson R, Gundamaraju R, Vemuri R, Angelucci C, Geraghty D, et al., 'Identification of key pro-survival proteins in isolated colonic goblet cells of Winnie, a murine model of spontaneous colitis', Inflammatory Bowel Diseases, 26, (1) pp. 80-92. ISSN 1536-4844 (2019) [Refereed Article] DOI: 10.1093/ibd/izz179 [eCite] [Details] Citations: Scopus - 4Web of Science - 4 Co-authors: Wilson R; Vemuri R; Angelucci C; Geraghty D; Guven N | |
| 2019 | Yong YK, Tan HY, Saeidi A, Wong WF, Vignesh R, et al., 'Immune biomarkers for diagnosis and treatment monitoring of tuberculosis: Current developments and future prospects', Frontiers in Microbiology, 10 pp. 1-18. ISSN 1664-302X (2019) [Refereed Article] DOI: 10.3389/fmicb.2019.02789 [eCite] [Details] Citations: Scopus - 30Web of Science - 28 | |
| 2018 | Ashworth Briggs EL, Toh T, Eri R, Hewitt AW, Cook AL, 'Uteroglobin and FLRG concentrations in aqueous humor are associated with age in primary open angle glaucoma patients', BMC Ophthalmology, 18, (1) pp. 1-8. ISSN 1471-2415 (2018) [Refereed Article] DOI: 10.1186/s12886-018-0723-4 [eCite] [Details] Citations: Scopus - 4Web of Science - 2 Co-authors: Ashworth Briggs EL; Hewitt AW; Cook AL | |
| 2018 | Gundamaraju R, Vemuri R, Chong WC, Myers S, Norouzi S, et al., 'Interplay between Endoplasmic Reticular Stress and Survivin in Colonic Epithelial Cells', Cells, 7, (10) Article 171. ISSN 2073-4409 (2018) [Refereed Article] DOI: 10.3390/cells7100171 [eCite] [Details] Citations: Scopus - 12Web of Science - 10 Co-authors: Vemuri R; Chong WC; Myers S; Norouzi S; Shastri MD | |
| 2018 | Perera AP, Fernando R, Shinde TS, Gundamaraju R, Southam B, et al., 'MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice', Scientific Reports, 8 Article 8618. ISSN 2045-2322 (2018) [Refereed Article] DOI: 10.1038/s41598-018-26775-w [eCite] [Details] Citations: Scopus - 146Web of Science - 143 Co-authors: Perera AP; Shinde TS; Southam B; Sohal SS; Kunde D | |
| 2018 | Perera AP, Sajnani K, Dickinson J, Eri R, Korner H, 'NLRP3 inflammasome in colitis and colitis-associated colorectal cancer', Mammalian Genome, 29, (11-12) pp. 817-830. ISSN 0938-8990 (2018) [Refereed Article] DOI: 10.1007/s00335-018-9783-2 [eCite] [Details] Citations: Scopus - 28Web of Science - 25 Co-authors: Perera AP; Dickinson J; Korner H | |
| 2018 | Ranasinghe R, Eri R, 'Pleiotropic immune functions of chemokine receptor 6 in health and disease', Medicines, 5, (3) Article 69. ISSN 2305-6320 (2018) [Refereed Article] | |
| 2018 | Ranson N, Veldhuis M, Mitchell B, Fanning S, Cook AL, et al., 'Nod-like receptor pyrin-containing protein 6 (NLRP6) is up-regulated in ileal Crohn's disease and differentially expressed in goblet cells', Cellular and Molecular Gastroenterology and Hepatology, 6, (1) pp. 110-112. ISSN 2352-345X (2018) [Refereed Article] DOI: 10.1016/j.jcmgh.2018.03.001 [eCite] [Details] Citations: Scopus - 15Web of Science - 15 Co-authors: Ranson N; Cook AL; Kunde D | |
| 2018 | Shastri MD, Shukla SD, Chong WC, Dua K, Peterson GM, et al., 'Role of oxidative stress in the pathology and management of human tuberculosis', Oxidative Medicine and Cellular Longevity, 2018 Article 7695364. ISSN 1942-0900 (2018) [Refereed Article] DOI: 10.1155/2018/7695364 [eCite] [Details] Citations: Scopus - 64Web of Science - 60 Co-authors: Shastri MD; Peterson GM; Patel RP; O'Toole RF | |
| 2018 | Vemuri R, Gundamaraju R, Shastri MD, Shukla SD, Kalpurath K, et al., 'Gut microbial changes, interactions, and their implications on human lifecycle: An ageing perspective', BioMed Research International, 2018 Article 4178607. ISSN 2314-6133 (2018) [Refereed Article] DOI: 10.1155/2018/4178607 [eCite] [Details] Citations: Scopus - 57Web of Science - 60 Co-authors: Vemuri R; Shastri MD; Shukla SD; Tristram S; Ahuja K | |
| 2018 | Vemuri R, Shinde TS, Gundamaraju R, Gondalia SV, Karpe AV, et al., 'Lactobacillus acidophilus DDS-1 modulates the gut microbiota and improves metabolic profiles in aging mice', Nutrients, 10, (9) Article 1255. ISSN 2072-6643 (2018) [Refereed Article] DOI: 10.3390/nu10091255 [eCite] [Details] Citations: Scopus - 42Web of Science - 42 Co-authors: Vemuri R; Shinde TS | |
| 2018 | Vemuri R, Shinde TS, Shastri MD, Perera AP, Tristram S, et al., 'A human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics', International Journal of Medical Sciences, 15, (9) pp. 840-848. ISSN 1449-1907 (2018) [Refereed Article] DOI: 10.7150/ijms.25004 [eCite] [Details] Citations: Scopus - 23Web of Science - 22 Co-authors: Vemuri R; Shinde TS; Shastri MD; Perera AP; Tristram S; Ahuja KDK | |
| 2018 | Vemuri R, Sylvia KE, Klein SL, Forster SC, Plebanski M, et al., 'The microgenderome revealed: sex differences in bidirectional interactions between the microbiota, hormones, immunity and disease susceptibility', Seminars in Immunopathology, 41, (2) pp. 265-275. ISSN 1863-2297 (2018) [Refereed Article] DOI: 10.1007/s00281-018-0716-7 [eCite] [Details] Citations: Scopus - 87Web of Science - 86 Co-authors: Vemuri R; Plebanski M; Flanagan KL | |
| 2017 | Cheluvappa R, Scowen P, Eri R, 'Ethics of animal research in human disease remediation, its institutional teaching; and alternatives to animal experimentation', Pharmacology Research and Perspectives, 5, (4) pp. 1-14. ISSN 2052-1707 (2017) [Refereed Article] DOI: 10.1002/prp2.332 [eCite] [Details] Citations: Scopus - 41Web of Science - 36 Co-authors: Scowen P | |
| 2017 | De Santis S, Kunde D, Galleggiante V, Liso M, Scandiffio L, et al., 'TNFα deficiency results in increased IL-1β in an early onset of spontaneous murine colitis', Cell Death and Disease, 8, (8) pp. 1-7. ISSN 2041-4889 (2017) [Refereed Article] DOI: 10.1038/cddis.2017.397 [eCite] [Details] Citations: Scopus - 16Web of Science - 17 Co-authors: Kunde D | |
| 2017 | Gundamaraju R, Vemuri R, Eri R, Ishiki HM, Coy-Barrera E, et al., 'Metabolomics as a functional tool in screening gastro intestinal diseases: Where are we in High Throughput Screening?', Combinatorial Chemistry and High Throughput Screening, 20, (3) pp. 247-254. ISSN 1386-2073 (2017) [Refereed Article] DOI: 10.2174/1386207319666161220122903 [eCite] [Details] Citations: Scopus - 4Web of Science - 4 Co-authors: Vemuri R | |
| 2017 | Kunde DA, Chong WC, Nerurkar PV, Ahuja KDK, Just J, et al., 'Bitter melon protects against ER stress in LS174T colonic epithelial cells', BMC Alternative Medicine, 17 Article 2. ISSN 1472-6882 (2017) [Refereed Article] DOI: 10.1186/s12906-016-1522-1 [eCite] [Details] Citations: Scopus - 12Web of Science - 11 Co-authors: Kunde DA; Chong WC; Ahuja KDK; Just J; Smith JA; Guven N | |
| 2017 | Perera AP, Kunde D, Eri R, 'NLRP3 inhibitors as potential therapeutic agents for treatment of inflammatory bowel disease', Current Pharmaceutical Design, 23, (16) pp. 2321-2327. ISSN 1381-6128 (2017) [Refereed Article] DOI: 10.2174/1381612823666170201162414 [eCite] [Details] Citations: Scopus - 35Web of Science - 28 Co-authors: Perera AP; Kunde D | |
| 2017 | Robinson AM, Rahman AA, Carbone SE, Randall-Demllo S, Filippone R, et al., 'Alterations of colonic function in the Winnie mouse model of spontaneous chronic colitis', AJP: Gastrointestinal and Liver Physiology, 312, (1) pp. G85-G102. ISSN 1522-1547 (2017) [Refereed Article] DOI: 10.1152/ajpgi.00210.2016 [eCite] [Details] Citations: Scopus - 24Web of Science - 24 Co-authors: Randall-Demllo S | |
| 2017 | Shastri S, Vemuri R, Guven N, Shastri MD, Eri R, 'Molecular mechanisms of intestinal inflammation leading to colorectal cancer', AIMS Biophysics, 4, (1) pp. 152-177. ISSN 2377-9098 (2017) [Refereed Article] DOI: 10.3934/biophy.2017.1.152 [eCite] [Details] Citations: Scopus - 3Web of Science - 2 Co-authors: Vemuri R; Guven N; Shastri MD | |
| 2017 | Vemuri RC, Gundamaraju R, Shinde TS, Eri R, 'Therapeutic interventions for gut dysbiosis and related disorders in the elderly: Antibiotics, probiotics or faecal microbiota transplantation?', Beneficial Microbes, 8, (2) pp. 179-192. ISSN 1876-2883 (2017) [Refereed Article] DOI: 10.3920/BM2016.0115 [eCite] [Details] Citations: Scopus - 38Web of Science - 38 Co-authors: Vemuri RC; Shinde TS | |
| 2016 | Booth C, Cheluvappa R, Bellinson Z, Maguire D, Zimitat C, et al., 'Empirical evaluation of a virtual laboratory approach to teach lactate dehydrogenase enzyme kinetics', Annals of Medicine and Surgery, 8 pp. 6-13. ISSN 2049-0801 (2016) [Refereed Article] DOI: 10.1016/j.amsu.2016.04.019 [eCite] [Details] Citations: Scopus - 11Web of Science - 8 Co-authors: Booth C; Zimitat C | |
| 2016 | De Santis S, Kunde D, Serino G, Galleggiante V, Caruso ML, et al., 'Secretory leukoprotease inhibitor is required for efficient quercetin-mediated suppression of TNFα secretion', Oncotarget, 7, (46) pp. 75800-75809. ISSN 1949-2553 (2016) [Refereed Article] DOI: 10.18632/oncotarget.12415 [eCite] [Details] Citations: Scopus - 32Web of Science - 29 Co-authors: Kunde D; Ranson N | |
| 2016 | Douglas T, Salter S, Iglesias M, Dowlman M, Eri R, 'The feedback process: Perspectives of first and second year undergraduate students in the disciplines of education, health science and nursing', Journal of University Teaching & Learning Practice, 13, (1) Article 3. ISSN 1449-9789 (2016) [Refereed Article] Co-authors: Douglas T; Salter S; Iglesias M; Dowlman M | |
| 2016 | Gundamaraju R, Vemuri R, Eri R, 'Overriding Elements in Colon Cancer Progression: Some Less Known Facts', Gastro, 2, (1) pp. 4-8. ISSN 2377-8369 (2016) [Contribution to Refereed Journal] DOI: 10.17140/GOJ-2-124 [eCite] [Details] Co-authors: Vemuri R | |
| 2016 | Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, et al., 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)', Autophagy, 12, (1) pp. 1-222. ISSN 1554-8627 (2016) [Refereed Article] DOI: 10.1080/15548627.2015.1100356 [eCite] [Details] Citations: Scopus - 3878Web of Science - 3260 Co-authors: Randall-Demllo S | |
| 2016 | Rahman AA, Robinson AM, Brookes SJH, Eri R, Nurgali K, 'Rectal prolapse in Winnie mice with spontaneous chronic colitis: changes in intrinsic and extrinsic innervation of the rectum', Cell and Tissue Research, 366, (2) pp. 285-299. ISSN 0302-766X (2016) [Refereed Article] DOI: 10.1007/s00441-016-2465-z [eCite] [Details] Citations: Scopus - 12Web of Science - 12 | |
| 2016 | Randall-Demllo S, Fernando R, Brain T, Sohal SS, Cook AL, et al., 'Characterisation of colonic dysplasia-like epithelial atypia in murine colitis', World Journal of Gastroenterology, 22, (37) pp. 8334-8348. ISSN 1007-9327 (2016) [Refereed Article] DOI: 10.3748/wjg.v22.i37.8334 [eCite] [Details] Citations: Scopus - 7Web of Science - 7 Co-authors: Randall-Demllo S; Sohal SS; Cook AL; Guven N; Kunde D | |
| 2016 | Robinson AM, Gondalia SV, Karpe AV, Eri R, Beale DJ, et al., 'Fecal microbiota and metabolome in a mouse model of spontaneous chronic colitis: relevance to human inflammatory bowel disease', Inflammatory Bowel Diseases, 22, (12) pp. 2767-2787. ISSN 1078-0998 (2016) [Refereed Article] DOI: 10.1097/MIB.0000000000000970 [eCite] [Details] Citations: Scopus - 31Web of Science - 30 | |
| 2015 | Ashworth Briggs EL, Toh TY, Eri RD, Hewitt A, Cook AL, 'TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients', Molecular Vision, 21 pp. 1162-1172. ISSN 1090-0535 (2015) [Refereed Article] PMID: 26539028 [eCite] [Details] Citations: Web of Science - 31 Co-authors: Ashworth Briggs EL; Hewitt A; Cook AL | |
| 2015 | Cheluvappa R, Eri R, 'Conjugate products of pyocyanin-glutathione reactions', Chemico-Biological Interactions: a journal of molecular, cellular and biochemical toxicology, 238 pp. 91-92. ISSN 0009-2797 (2015) [Letter or Note in Journal] DOI: 10.1016/j.cbi.2015.06.002 [eCite] [Details] Citations: Scopus - 1 | |
| 2015 | Cheluvappa R, Eri R, Luo AS, Grimm MC, 'Modulation of interferon activity-associated soluble molecules by appendicitis and appendectomy limits colitis-identification of novel anti-colitic targets', Journal of Interferon and Cytokine Research, 35, (2) pp. 108-115. ISSN 1079-9907 (2015) [Refereed Article] DOI: 10.1089/jir.2014.0091 [eCite] [Details] Citations: Scopus - 9Web of Science - 9 | |
| 2015 | Eapen MS, Shukla SD, Mahmood MQ, McAlinden-Volkovickas KD, Eri RD, et al., 'Current understanding of corticosteroid therapy in chronic obstructive pulmonary disease (COPD): an overview', International Journal of Medical and Biological Frontiers, 21, (1) ISSN 1081-3829 (2015) [Non Refereed Article] Co-authors: Eapen MS; Shukla SD; Mahmood MQ; McAlinden-Volkovickas KD; Walters EH; Sohal SS | |
| 2015 | Fox MJ, Ahuja KDK, Robertson IK, Ball MJ, Eri RD, 'Can probiotic yogurt prevent diarrhoea in children on antibiotics? A double-blind, randomised, placebo-controlled study', BMJ, 5, (1) Article e006474. ISSN 1756-1833 (2015) [Refereed Article] DOI: 10.1136/bmjopen-2014-006474 [eCite] [Details] Citations: Scopus - 55Web of Science - 49 Co-authors: Fox MJ; Ahuja KDK; Robertson IK; Ball MJ | |
| 2015 | Lean QY, Eri RD, Fitton JH, Patel RP, Gueven N, 'Fucoidan extracts ameliorate acute colitis', PLoS One, 10, (6) Article e0128453. ISSN 1932-6203 (2015) [Refereed Article] DOI: 10.1371/journal.pone.0128453 [eCite] [Details] Citations: Scopus - 65Web of Science - 54 Co-authors: Lean QY; Patel RP; Gueven N | |
| 2015 | Lean QY, Eri RD, Randall-Demllo S, Sohal SS, Stewart N, et al., 'Orally Administered Enoxaparin Ameliorates Acute Colitis by Reducing Macrophage-Associated Inflammatory Responses', PLoS One, 10, (7) Article e0134259. ISSN 1932-6203 (2015) [Refereed Article] DOI: 10.1371/journal.pone.0134259 [eCite] [Details] Citations: Scopus - 19Web of Science - 15 Co-authors: Lean QY; Randall-Demllo S; Sohal SS; Stewart N; Peterson GM; Guven N; Patel RP | |
| 2015 | Lean QY, Gueven N, Eri RD, Bhatia R, Sohal SS, et al., 'Heparins in ulcerative colitis: proposed and potential reasons for inconsistent clinical outcomes', Expert Review of Clinical Pharmacology, 8, (6) pp. 795-811. ISSN 1751-2433 (2015) [Refereed Article] DOI: 10.1586/17512433.2015.1082425 [eCite] [Details] Citations: Scopus - 12Web of Science - 11 Co-authors: Lean QY; Gueven N; Sohal SS; Stewart N; Peterson GM; Patel RP | |
| 2015 | Rahman AA, Robinson AM, Jovanovska V, Eri RD, Nurgali K, 'Alterations in the distal colon innervation in Winnie mouse model of spontaneous chronic colitis', Cell and Tissue Research, 362, (3) pp. 497-512. ISSN 0302-766X (2015) [Refereed Article] DOI: 10.1007/s00441-015-2251-3 [eCite] [Details] Citations: Scopus - 25Web of Science - 24 | |
| 2015 | Wang R, Hasnain SZ, Tong H, Das I, Che-Hao Chen A, et al., 'Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model', Inflammatory Bowel Diseases, 21, (5) pp. 973-84. ISSN 1078-0998 (2015) [Refereed Article] DOI: 10.1097/MIB.0000000000000353 [eCite] [Details] Citations: Scopus - 24Web of Science - 23 | |
| 2014 | Alkadhi S, Kunde D, Cheluvappa R, Randall-Demllo S, Eri R, 'The murine appendiceal microbiome is altered in spontaneous colitis and its pathological progression', Gut pathogens, 6 Article 25. ISSN 1757-4749 (2014) [Refereed Article] DOI: 10.1186/1757-4749-6-25 [eCite] [Details] Citations: Scopus - 31Web of Science - 30 Co-authors: Kunde D; Randall-Demllo S | |
| 2014 | Cheluvappa R, Eri R, Luo AS, Grimm MC, 'Endothelin and vascular remodelling in colitis pathogenesis - Appendicitis and appendectomy limit colitis by suppressing endothelin pathways', International Journal of Colorectal Disease, 29, (11) pp. 1321-1328. ISSN 0179-1958 (2014) [Refereed Article] DOI: 10.1007/s00384-014-1974-z [eCite] [Details] Citations: Scopus - 9Web of Science - 6 | |
| 2014 | Eri R, 'Peer observation of teaching: reflections of an early career academic', Universal Journal of Educational Research, 2, (9) pp. 625-631. ISSN 2332-3205 (2014) [Refereed Article] | |
| 2014 | Eri R, Cook A, Brown N, 'Reflections on the value of mapping the final theory examination in a molecular biochemistry unit', Journal of Microbiology and Biology Education, 15, (1) pp. 53-54. ISSN 1935-7885 (2014) [Refereed Article] DOI: 10.1128/jmbe.v15i1.679 [eCite] [Details] Co-authors: Cook A; Brown N | |
| 2013 | Das I, Png CW, Oancea I, Hasnain SZ, Lourie R, et al., 'Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins', The Journal of Experimental Medicine, 210, (6) pp. 1201-1216. ISSN 0022-1007 (2013) [Refereed Article] DOI: 10.1084/jem.20121268 [eCite] [Details] Citations: Scopus - 64Web of Science - 64 | |
| 2013 | Oancea I, Png CW, Das I, Lourie R, Winkler I, et al., 'A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity', Gut: An International Journal of Gastroenterology and Hepatology, 62, (4) pp. 594-605. ISSN 0017-5749 (2013) [Refereed Article] DOI: 10.1136/gutjnl-2012-302274 [eCite] [Details] Citations: Scopus - 42Web of Science - 42 | |
| 2013 | Shabala L, Walker EJ, Eklund A, Randall-Demllo S, Shabala S, et al., 'Exposure of colonic epithelial cells to oxidative and endoplasmic reticulum stress causes rapid potassium efflux and calcium influx', Cell Biochemistry and Function, 31, (7) pp. 603-611. ISSN 1099-0844 (2013) [Refereed Article] DOI: 10.1002/cbf.2946 [eCite] [Details] Citations: Scopus - 7Web of Science - 7 Co-authors: Shabala L; Walker EJ; Randall-Demllo S; Shabala S; Guven N; Cook AL | |
| 2011 | Eri RD, Adams RJ, Tran TV, Tong H, Das I, et al., 'An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity', Mucosal Immunology, 4, (3) pp. 354-364. ISSN 1933-0219 (2011) [Refereed Article] DOI: 10.1038/mi.2010.74 [eCite] [Details] Citations: Scopus - 101Web of Science - 91 | |
| 2011 | McGuckin MA, Eri RD, Das I, Lourie R, Florin TH, 'Intestinal secretory cell ER stress and inflammation', Biochemical Society Transactions, 39, (4) pp. 1081-1085. ISSN 0300-5127 (2011) [Refereed Article] DOI: 10.1042/BST0391081 [eCite] [Details] Citations: Scopus - 38Web of Science - 36 | |
| 2010 | McGuckin MA, Eri RD, Das I, Lourie R, Florin TH, 'ER stress and the unfolded protein response in intestinal inflammation', American Journal of Physiology: Gastrointestinal and Liver Physiology , 298, (6) pp. G820-G832. ISSN 0193-1857 (2010) [Refereed Article] DOI: 10.1152/ajpgi.00063.2010 [eCite] [Details] Citations: Scopus - 136Web of Science - 130 | |
| 2009 | McGuckin MA, Eri RD, Simms LA, Florin TH, Radford-Smith G, 'Intestinal barrier dysfunction in inflammatory bowel diseases', Inflamm. Bowel Dis, 15, (1) pp. 100-113. ISSN 1536-4844 (2009) [Refereed Article] DOI: 10.1002/ibd.20539 [eCite] [Details] Citations: Scopus - 441Web of Science - 414 | |
| 2008 | Eri RD, Heazlewood CK, Cook MC, Price GR, Tauro SB, et al., 'Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis', PLoS Med, 5, (3) pp. E54. ISSN 1549-1676 (2008) [Refereed Article] DOI: 10.1371/journal.pmed.0050054 [eCite] [Details] Citations: Scopus - 535Web of Science - 507 | |
| 2008 | Eri RD, Kodumudi N, Summerlin D, Srinivasan M, 'Suppression of colon inflammation by CD80 blockade: Evaluation in two murine models of inflammatory bowel disease', Inflammatory Bowel Disease, 14, (4) pp. 458-470. ISSN 1536-4844 (2008) [Refereed Article] DOI: 10.1002/ibd.20344 [eCite] [Details] Citations: Scopus - 22Web of Science - 21 | |
| 2008 | O'Malley JT, Eri RD, Stritesky GL, Mathur AN, Chang HC, et al., 'STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease', Journal of Immunology, 181, (7) pp. 5062-5070. ISSN 0022-1767 (2008) [Refereed Article] DOI: 10.4049/jimmunol.181.7.5062 [eCite] [Details] Citations: Scopus - 30Web of Science - 29 | |
| 2007 | Srinivasan M, Eri RD, Zunt SL, Summerlin DJ, Brand DD, et al., 'Suppression of immune responses in collagen-induced arthritis by a rationally designed CD80-binding peptide agent', Arthritis & Rheumatism, 56, (2) pp. 498-508. ISSN 1529-0131 (2007) [Refereed Article] DOI: 10.1002/art.22324 [eCite] [Details] Citations: Scopus - 13Web of Science - 12 | |
| 2006 | Hume GE, Fowler EV, Lincoln D, Eri RD, Templeton D, et al., 'Angiotensinogen and transforming growth factor beta1: novel genes in the pathogenesis of Crohn's disease', Journal of Medical Genetics, 43, (10) pp. e51. ISSN 1468-6244 (2006) [Refereed Article] DOI: 10.1136/jmg.2005.040477 [eCite] [Details] Citations: Scopus - 25Web of Science - 20 | |
| 2006 | Michael-Robinson JM, Pandeya N, Walsh MD, Biemer-Huttmann AE, Eri RD, et al., 'Characterization of tumour-infiltrating lymphocytes and apoptosis in colitis-associated neoplasia: comparison with sporadic colorectal cancer', The Journal of Pathology, 208, (3) pp. 381-387. ISSN 1096-9896 (2006) [Refereed Article] DOI: 10.1002/path.1895 [eCite] [Details] Citations: Scopus - 17Web of Science - 15 | |
| 2005 | Fowler EV, Eri RD, Hume G, Johnstone S, Pandeya N, et al., 'GLTNFalpha and IL10 SNPs act together to predict disease behaviour in Crohn's disease', Journal of Medical Genetics, 42, (6) pp. 523-528. ISSN 1468-6244 (2005) [Refereed Article] DOI: 10.1136/jmg.2004.027425 [eCite] [Details] Citations: Scopus - 52Web of Science - 47 | |
| 2005 | Fukata M, Michelsen KS, Eri RD, Thomas LS, Hu B, et al., 'Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis', American Journal of Physiology: Gastrointestinal and Liver Physiology, 288, (5) pp. 1055-1065. ISSN 0193-1857 (2005) [Refereed Article] DOI: 10.1152/ajpgi.00328.2004 [eCite] [Details] Citations: Scopus - 418Web of Science - 381 | |
| 2005 | Srinivasan M, Lu D, Eri RD, Brand DD, Haque A, et al., 'CD80 binding polyproline helical peptide inhibits T cell activation', Journal of Biological Chemistry, 280, (11) pp. 10149-10155. ISSN 0021-9258 (2005) [Refereed Article] DOI: 10.1074/jbc.M409521200 [eCite] [Details] Citations: Scopus - 20Web of Science - 19 | |
| 2004 | Eri RD, Jonsson JR, Pandeya N, Purdie DM, Clouston AD, et al., 'CCR5-Delta32 mutation is strongly associated with primary sclerosing cholangitis', Genes and Immunity, 6, (6) pp. 444-450. ISSN 1466-4879 (2004) [Refereed Article] DOI: 10.1038/sj.gene.6364113 [eCite] [Details] Citations: Web of Science - 45 | |
| 1999 | Eri RD, Arnold J, Hinman V, Green K, Jones M, et al., 'Hemps, a novel EGF-like protein plays a central role in ascidian metamorphosis', Development (Cambridge), 126, (24) pp. 5809-5818 . ISSN 0950-1991 (1999) [Refereed Article] Citations: Web of Science - 57 | |
| 1997 | Arnold J, Eri RD, Degnan B, Lavin MF, 'Novel gene containing multiple epidermal growth factor-like motifs transiently expressed in the papillae of the ascidian tadpole larvae', Developmental Dynamics, 210, (3) pp. 264-273. ISSN 1058-8388 (1997) [Refereed Article] DOI: 10.1002/(SICI)1097-0177(199711)210:3<264::AID-AJA7>3.3.CO;2-D [eCite] [Details] Citations: Web of Science - 17 |
Chapter in Book
(3 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2016 | Lean QY, Gueven N, Eri RD, Peterson GM, Patel RP, 'Non-Anticoagulant Oligosaccharides of Enoxaparin Relieve Chemical-Induced Acute Colitis', Advances in Medicine and Biology, Nova Science Publishers, LV Berhardt (ed), United States, pp. 87-104. ISBN 978-1-63483-988-4 (2016) [Research Book Chapter] Co-authors: Lean QY; Gueven N; Peterson GM; Patel RP | |
| 2015 | Eapen MS, Shukla SD, Mahmood MQ, McAlinden-Volkovickas KD, Eri RD, et al., 'Role of corticosteroids in chronic obstructive pulmonary disease (COPD)', Corticosteroids and Steroid Therapy: New Research, Nova Science Publishers, C Adkins (ed), United Kingdom, pp. 1-40. ISBN 978-1634823081 (2015) [Research Book Chapter] Co-authors: Eapen MS; Shukla SD; Mahmood MQ; McAlinden-Volkovickas KD; Walters EH; Sohal SS | |
| 2012 | Eri RD, McGuckin MA, Wadley R, 'T cell transfer model of colitis: a great tool to assess the contribution of T cells in chronic intestinal inflammation', Leucocytes: Methods and Protocols, Methods in Molecular Biology, Humana Press, Robert B. Ashman (ed), United States, pp. 261-275. ISBN 978-1-61779-526-8 (2012) [Research Book Chapter] DOI: 10.1007/978-1-61779-527-5_19 [eCite] [Details] Citations: Scopus - 38 |
Review
(12 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2019 | Ranasinghe R, Eri R, 'CCR6-CCL20-Mediated Immunologic Pathways in Inflammatory Bowel Disease', Gastrointestinal Disorders, 1, (1) pp. 15-29. ISSN 2624-5647 (2019) [Review Several Works] DOI: 10.3390/gidisord1010003 [eCite] [Details] Citations: Web of Science - 4 | |
| 2019 | Ranasinghe R, Eri R, 'CCR6-CCL20 Axis in IBD: What Have We Learnt in the Last 20 Years?', Gastrointestinal Disorders, 1 pp. 57-74. ISSN 2624-5647 (2019) [Review Several Works] DOI: 10.3390/gidisord1010006 [eCite] [Details] Citations: Web of Science - 4 | |
| 2018 | Ranasinghe R, Eri R, 'Modulation of the CCR6-CCL20 Axis: A Potential Therapeutic Target in Inflammation and Cancer', Medicina, 54, (5) pp. 1-12. ISSN 1010-660X (2018) [Review Several Works] DOI: 10.3390/medicina54050088 [eCite] [Details] Citations: Scopus - 32Web of Science - 30 | |
| 2018 | Ranson N, Kunde D, Eri R, 'Regulation and sensing of inflammasomes and their impact on intestinal health', International Journal of Molecular Sciences, 18, (11) pp. 1-19. ISSN 1661-6596 (2018) [Substantial Review] DOI: 10.3390/ijms18112379 [eCite] [Details] Citations: Scopus - 20Web of Science - 15 Co-authors: Ranson N; Kunde D | |
| 2017 | Chong WC, Shastri MD, Eri R, 'Endoplasmic reticulum stress and oxidative stress: A vicious nexus implicated in bowel disease pathophysiology', International Journal of Molecular Sciences, 18 (4) Article 771. ISSN 1661-6596 (2017) [Substantial Review] DOI: 10.3390/ijms18040771 [eCite] [Details] Citations: Scopus - 136Web of Science - 118 Co-authors: Chong WC; Shastri MD | |
| 2017 | Vemuri R, Gundamaraju R, Eri R, 'Role of lactic acid probiotic bacteria in IBD', Current Pharmaceutical Design, 23, (16) pp. 2352-2355. ISSN 1381-6128 (2017) [Review Several Works] DOI: 10.2174/1381612823666170207100025 [eCite] [Details] Citations: Scopus - 24Web of Science - 20 Co-authors: Vemuri R | |
| 2013 | Basheer W, Kunde DA, Eri RD, 'Role of Chemokine Ligand CCL20 and its Receptor CCR6 in lntestinal Inflammation', Immunology and Infectious Diseases, 1, (2) pp. 30-37. ISSN 2333-2719 (2013) [Substantial Review] DOI: 10.13189/iid.2013.010203 [eCite] [Details] Co-authors: Basheer W; Kunde DA | |
| 2013 | Eri RD, Chieppa M, 'Messages from the inside. The dynamic environment that favors intestinal homeostasis', Frontiers in Immunology, 4 pp. 1-7. ISSN 1664-3224 (2013) [Substantial Review] DOI: 10.3389/fimmu.2013.00323 [eCite] [Details] Citations: Scopus - 21Web of Science - 20 | |
| 2013 | Fox M, Ahuja KDK, Eri RD, 'Efficacy of probiotics in the prevention of antibiotic-associated diarrhoea (AAD) in children - a review', International Journal of Probiotics and Prebiotics, 8, (2/3) pp. 61-66. ISSN 1555-1431 (2013) [Substantial Review] Co-authors: Fox M; Ahuja KDK | |
| 2013 | Lee AYS, Eri RD, Lyons AB, Grimm MC, Korner H, 'CC chemokine ligand 20 and its cognate receptor CCR6 in mucosal T cell immunology and inflammatory bowel disease: odd couple or axis of evil?', Frontiers in Immunology, 4, (194) pp. 1-7. ISSN 1664-3224 (2013) [Substantial Review] DOI: 10.3389/fimmu.2013.00194 [eCite] [Details] Citations: Scopus - 65Web of Science - 66 Co-authors: Lee AYS; Lyons AB; Korner H | |
| 2013 | Randall-Demllo S, Chieppa M, Eri RD, 'Intestinal epithelium and autophagy: partners in gut homeostasis', Frontiers in Immunology, 4 pp. 1-14. ISSN 1664-3224 (2013) [Substantial Review] DOI: 10.3389/fimmu.2013.00301 [eCite] [Details] Citations: Scopus - 80Web of Science - 76 Co-authors: Randall-Demllo S | |
| 2013 | Ranson NM, Eri RD, 'The Role of Inflammasomes in Intestinal Inflammation', American Journal of Medical and Biological Research, 1, (3) pp. 64-76. ISSN 2328-4080 (2013) [Substantial Review] DOI: 10.12691/ajmbr-1-3-3 [eCite] [Details] Co-authors: Ranson NM |
Conference Publication
(9 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2022 | Ahmad T, Ishaq M, Eapen M, Singh Neeraj, Park A, et al., 'Fucoidan as an inhibitor of pro-inflammatory cytokines: potential candidate for treating inflammatory-related conditions', FASEB Journal, April 2-5 2022, Philidephia ISSN 1530-6860 (2022) [Conference Extract] DOI: 10.1096/fasebj.2022.36.S1.L7837 [eCite] [Details] Co-authors: Ahmad T; Ishaq M; Eapen M; Singh Neeraj; Park A; Karpiniec S; Stringer D; Fitton H; Caruso V | |
| 2021 | Eri RD, 'Biosimilars in inflammatory bowel disease: copycats or genuine replacements?', The Biomedical & Life Sciences Collection, Henry Stewart Talks, 28 April 2021, online ISSN 2056-452X (2021) [Non Refereed Conference Paper] | |
| 2017 | Kunde D, Ranson N, Chieppa M, Eri RD, 'W65 - The NLRP3 Inflammasome is Differentially Activated During Active Ulcerative Colitis and Crohn's Disease', 18th International Congress of Mucosal Immunology (ICMI), 19 - 22 July 2017, Washington DC (2017) [Conference Extract] Co-authors: Kunde D; Ranson N | |
| 2017 | Shinde TS, Tristram SG, Stanley RA, Eri RD, 'Survival, adhesion and immunomodulatory efficacy of spore-forming probiotic Bacillus coagulans', Australian Society for Microbiology National Scientific Meeting, Hobart 2017, 2-5 July, Hobart, Tasmania (2017) [Conference Extract] Co-authors: Shinde TS; Tristram SG; Stanley RA | |
| 2016 | Perera AP, Ranson N, Sohal SS, Eri RD, 'Major Role of NLRP3 Inflammasome in Colitis Progression', International Congress of Immunology (ICI), 21 - 26 August, Melbourne, Australia (2016) [Conference Extract] Co-authors: Perera AP; Ranson N; Sohal SS | |
| 2016 | Ranson N, Kunde D, Eri R, 'Inflammasomes and Intestinal Inflammation', International Congress of Immunology (ICI), 21 - 26 August, Melbourne, Australia (2016) [Conference Extract] Co-authors: Ranson N; Kunde D | |
| 2015 | Eri RD, Ranson N, 'Hierarchical Inflammasome Activation In The Inflammatory Bowel Diseases', 17th International Congress of Mucosal Immunology (ICMI), 14 - 18 July, Berlin, Germany (2015) [Conference Extract] Co-authors: Ranson N | |
| 2014 | Cook AL, Ashworth Briggs EL, Toh T, Eri RD, Hewitt A, 'Defining conditions to direct human pluripotent stem cells towards the glaucoma-affected trabecular meshwork cell lineage', 2014 Australian Health and Medical Research Congress (AHMRC), 16-19 November, 2014, Melbourne, Australia (2014) [Conference Extract] Co-authors: Cook AL; Ashworth Briggs EL; Hewitt A | |
| 2014 | Fox MJ, Ahuja KDK, Robertson IK, Ball MJ, Eri RD, 'Probiotic yoghurt and incidence of diarrhoea in children: a double blind, randomised, controlled trial', Thirty-Eighth Annual Scientific Meeting of The Nutrition Society of Australia, 26 - 28 November, 2014, Hobart, Tasmania (2014) [Conference Extract] Co-authors: Fox MJ; Ahuja KDK; Robertson IK; Ball MJ |
Patent
(1 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2019 | Eri RD, Edwards G, Taylor KJN, Stanley RA, Shinde TS, 'Preparation for the Treatment of Inflammatory Bowel Disease using a Whole Plant Fibre Extract from Sugar Cane' (2019) [Patent] Co-authors: Stanley RA; Shinde TS |
Major Creative Work
(1 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2016 | Bywaters MC, Lehman K, Eri R, Huang T, Fan F, 'Navigating the internal landscape: an artistic interpretation of disease', University of Tasmania, Academy Gallery - Launceston and Makers Space - Burnie, 500, pp. 8 (2016) [Other Exhibition] Co-authors: Bywaters MC; Lehman K; Huang T |
Other Public Output
(1 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2014 | Simpson H, Duers L, Rankin J, McFadyen J, Campbell SJ, et al., 'Health Benchmarking Project Final Report', University of Tasmania and University of the West of Scotland, pp. 1-45. (2014) [Government or Industry Research] Co-authors: Campbell SJ; Stirling CM; Walsh K; Ford K; Geraghty DP; Williams AD; Robinson AL; Miller AB; Cross M; McKay AJ; Sondermeyer J; Elmer SL; Cooper JF; Booth S |
Grants & Funding
Funding Summary
Number of grants
28
Total funding
Projects
- Description
- Cancer is the leading cause of mortality in Australia and is expected to account for around 50,000 deaths in 2021. Most cancer patients undergo chemotherapy treatment; however, it is associated with many complications including widespread mucositis (painful inflammation and ulcer), manifesting as pain, inflammation, bleeding, risk of infections and diarrhoea. The severity of chemotherapy induced symptoms commonly leads to complete cessation of chemotherapy, compromising the patient's cancer treatment. Prebiotic fibre and probiotics have, individually, demonstrated a tremendous potential in the treatment of gut complications. Recent preclinical studies in our laboratory using synbiotics (a combination of prebiotics and probiotics) have provided exciting evidence of their anti-inflammatory and mucosal healing effects. Such promising results have prompted us to investigate the potential benefit of synbiotics in patients receiving chemotherapy.
- Funding
- Health Food Symmetry Ltd ($29,970)
- Scheme
- Contract Research
- Administered By
- University of Tasmania
- Research Team
- Eri RD; Beckett JM
- Year
- 2022
- Description
- Cognitive dysfunction is common in people with Multiple Sclerosis (MS) and can cause significant disruption to everyday functioning and quality of life. Peculiarities in gut microbial composition and function have also been found in people with MS and there is now a recognised link between the gut microbiome and kynurenine pathway (KP) regulation, as well as KP dysregulation, increased inflammation and neuronal death. This research aims to conduct a pilot study investigating whether and to what extent a nutrition intervention (e.g., probiotics) may influence cognitive impairment in MS, by modulating KP function via the gut microbiome.
- Funding
- Multiple Sclerosis Australia ($70,000)
- Scheme
- Scholarship-Postgraduate
- Administered By
- University of Tasmania
- Research Team
- Honan CA; Eri RD; Purton T
- Period
- 2022 - 2023
- Description
- The central hypothesis to be tested by this series of clinical research is that post-traumatic stress disorder can be regulated with ketamine. The study has two parts, Part A investigates effects of Emergency Department administration of ketamine following trauma on subsequent mental health outcomes. It is hypothesised that trauma patients treated with ketamine will have better outcomes. Part B investigates patients' knowledge and attitudes to future mental health treatments with ketamine. It is hypothesised that community perceptions of ketamine treatments may be negative.Test the following aims:Aim 1: Determine the effects of ketamine on scores for PTSD, depression and anxiety in ED patients treated with ketamine as part of trauma treatments (LGH Emergency Department)Aim 2: Establish if patients' perceptions of ketamine treatments for mental health are positive or negative (North west Tasmania Psychiatry outpatients).
- Funding
- Clifford Craig Foundation ($72,726)
- Scheme
- Grant
- Administered By
- University of Tasmania
- Research Team
- Johnson OL; Murtagh L; Ravindran MA; Eri RD; Raut SB
- Period
- 2022 - 2023
- Description
- Cognitive dysfunction is common in people with Multiple Sclerosis (MS) and can cause significant disruption to everyday functioning and quality of life. Peculiarities in gut microbial composition and function have also been found in people with MS and there is now a recognised link between the gut microbiome and kynurenine pathway (KP) regulation, as well as KP dysregulation, increased inflammation and neuronal death. This research aims to examine whether cognitive dysfunction and cognitive changes over time (approximately a 4-year period, time 1 data was collected in 2016/2017) are associated with increased pro-inflammatory KP biomarkers and an aberrant gut microbiota among individuals with MS. We will also conduct a pilot study investigating whether and to what extent a nutrition intervention (e.g., probiotics) may influence cognitive impairment in MS, by modulating KP function via the gut microbiome.
- Funding
- Clifford Craig Foundation ($57,683)
- Scheme
- Grant
- Administered By
- University of Tasmania
- Research Team
- Honan CA; Eri RD; Giles L; Johnson OL; Marx W; Lim E; Ahuja KDK
- Period
- 2021 - 2022
- Funding
- Clifford Craig Foundation ($7,000)
- Scheme
- Grant
- Administered By
- Launceston General Hospital
- Research Team
- Eri RD; Flanagan K
- Year
- 2018
- Description
- Our lab has generated a novel mouse model of ulcerative colitis-induced colorectal cancer. We will investigate the molecular mechanisms involved in the transformation of colitis to colorectal cancer.
- Funding
- Cancer Council of Tasmania ($24,940)
- Scheme
- Grant-Small
- Administered By
- University of Tasmania
- Research Team
- Shastri M; Eri RD
- Year
- 2018
- Description
- Vaccine trial involving older adults in Launceston. The projects investigates the immune responses to vaccination in the elderly.
- Funding
- Launceston General Hospital ($54,437)
- Scheme
- Contract Research
- Administered By
- University of Tasmania
- Research Team
- Eri RD; Flanagan K; Byrne N
- Period
- 2017 - 2019
- Description
- Funding will be provided for two projects which utilise the KFSU product K-fibreTM. Project 1: Efficacy of K-fibre in ameliorating gut inflammation in animal model of colitis; Project 2: Efficacy of Kfibre in combating Gastroesophageal Reflux Disease Preliminary Human Clinical Study.
- Funding
- KFSU Ltd ($74,871)
- Scheme
- Contract Research
- Administered By
- University of Tasmania
- Research Team
- Eri RD; Stanley RA
- Period
- 2017 - 2018
- Description
- We propose to conduct functional study involving blockade of protein complexes called inflammasomes in inflammatory bowel disease. The project will utilise human tissue to understand therapeutic efficacy of inflammasome blocking.
- Funding
- Clifford Craig Foundation ($34,687)
- Scheme
- Grant
- Administered By
- University of Tasmania
- Research Team
- Eri RD; Kunde DA; Mitchell B; Fanning S
- Year
- 2017
- Description
- We propose to conduct functional study involving blockade of protein complexes called inflammasomes in inflammatory bowel disease. The project will utilise human tissue to understand therapeutic efficacy of inflammasome blocking.
- Funding
- Gastroenterological Society of Australia ($22,727)
- Scheme
- Award-Takeda IBD
- Administered By
- University of Tasmania
- Research Team
- Eri RD; Veldhuis M
- Period
- 2017 - 2018
- Description
- Our understanding of many cancers has improved dramatically over the past decade predominantly due to our ability to sequence entire genomes, at scale. Yet, we still require a better understanding of the underlying mechanisms that initiate and perpetuate cancers, as well as gene-based factors that initiate the transition from indolent to aggressive cancers with a propensity to metastasize. CRISPR/Cas is proving a robust, powerful and necessary tool in the laboratory that will undoubtedly underpin the next breakthrough in the field of cancer. As such, it is essential that we develop this capability at the University of Tasmania in a timely manner.The specific AIMS of this proposal are to:Aim 1: Establish CRISPR/Cas screening at the University of Tasmania as a tool to identify genesthat drive aggressive and metastatic cancers.Aim 2: Perform a genome-wide CRISPR/Cas negative selection (loss-of-function) screen toidentify genes essential for proliferation and survival, as well as metastatic behaviour.
- Funding
- University of Tasmania Foundation Inc ($63,845)
- Scheme
- Grant-Cancer Research
- Administered By
- University of Tasmania
- Research Team
- Taberlay PC; Hewitt A; Holloway AF; Liu G; Dickinson JL; Brettingham-Moore KH; Fitzgerald L; Eri RD; Cook AL
- Year
- 2017
- Description
- Industry interaction to develop Marinova's fucoidan extracts for gut health
- Funding
- Department of Industry, Innovation and Science ($50,000); Marinova Pty Ltd ($50,000)
- Scheme
- Contract Research
- Administered By
- University of Tasmania
- Research Team
- Guven N; Eri RD; Ahuja KDK; Ball MJ; Ambrose M; Roddam LF; Zosky GR
- Year
- 2016
- Description
- This project will be the first study to model early changes in inflammation-associated colitis without the need for carcinogentreatment, which mirrors the clinical situation of human colitis. The project will study the histological and biochemical changes associated with the development of colorectal cancer in this mouse model that closely resembles the development seen in humans. The project will also investigate the mirobiome changes in the progression.
- Funding
- Cancer Council of Tasmania ($28,000)
- Scheme
- Grant-Cancer Research
- Administered By
- University of Tasmania
- Research Team
- Kunde DA; Eri RD; Holloway AF
- Year
- 2016
- Description
- Small airway fibrosis is the main contributor to physiological airway obstruction in COPD. The other main airway pathology in COPD is lung cancer; up to 70% of smoking related lung cancer occurs in mild-moderate COPD. EMT may underlie both pathological features; if true this opens up major new therapeutic possibilities. We aim to investigate EMT in airways of smokers and COPD.
- Funding
- Clifford Craig Foundation ($39,206)
- Scheme
- Grant
- Administered By
- University of Tasmania
- Research Team
- Sohal SS; Chia C; Larby J; Haug G; Eri RD; Myers SA; Noor WD
- Year
- 2016
- Description
- Industry interaction to test if Marinova's fucoidan extracts mobilise stem cells.
- Funding
- Marinova Pty Ltd ($27,048)
- Scheme
- Clinical Trial
- Administered By
- University of Tasmania
- Research Team
- Guven N; Eri RD; Ahuja KDK; Patel RP
- Year
- 2015
- Description
- This project draws on latest research results from the fields of visual arts, visualisation, health and education and aims to design and evaluate artistic interaction methods. It is hypothesised that by introducing artistic interactions, users will be more engaged with the sense-making process, thus making the visualisation more effective in conveying the embedded information to the end users, in comparison with traditional reality based interactions.
- Funding
- University of Tasmania ($6,856)
- Scheme
- Grant-Cross-Disciplinary Incentive
- Administered By
- University of Tasmania
- Research Team
- Bywaters MC; Huang W; Fan S; Lehman KF; Eri RD
- Year
- 2015
- Description
- This project represents industry interaction to develop Marinova's fucoidan extract for gut health.
- Funding
- Department of Industry, Science, Energy and Resources ($50,000)
- Scheme
- Grant
- Administered By
- University of Tasmania
- Research Team
- Guven N; Davis E; Eri RD; Patel RP
- Year
- 2015
- Description
- This project aims to achieve the identification and evaluation of non-anticoagulant molecules of heparin that are responsible for the observed beneficial effects of heparin in patients with ulcerative colitis as well as to compare potential biomarkers in a preclinical muse model with ulcerative colitis patients.
- Funding
- Royal Hobart Hospital Research Foundation ($15,000)
- Scheme
- Grant-Clinical Research
- Administered By
- University of Tasmania
- Research Team
- Patel RP; Guven N; Eri RD; Bhatia R
- Year
- 2015
- Funding
- Department of Health and Human Services Tasmania ($7,000)
- Scheme
- Donation - Individual
- Administered By
- University of Tasmania
- Research Team
- Eri RD
- Year
- 2014
- Description
- Glaucoma is a degenerative disease attributed to progressive loss of neurons within the optic nerve. There is no cure for this disease, with treatment strategies predominantly focused on reducing intraocular pressure (IOP), which remains the only modifiable risk factor. IOP is generally considered to be due to inhibited outflow of aqueous humor, the fluid within the eye, through a specialised tissue known as the trabecular meshwork. The trabecular meshwork (TM) is highly fibrous, consisting of several layers of cells overlying extracellular matrix (ECM) structures. During normal ageing, increased ECM deposition occurs in the deeper layers of the trabecular meshwork, and this appears to be increased in glaucoma. It is not known how this occurs, but it has been speculated that changes in expression and activity of ECM remodelling proteins, typified by matrix metalloproteinases (MMPs) and their regulators, tissue inhibitor of metalloproteinases (TIMPs), may be responsible. Several studies have examined gene expression and the ECM structure in normal and glaucomatous trabecular meshwork, as well as the presence of MMPs and TIMPS in aqueous humor, but no study has attempted to correlate the extent of ECM deposition with MMP or TIMP activity using trabecular meshwork tissue and aqueous humor from the same patient.
- Funding
- Clifford Craig Foundation ($36,235)
- Scheme
- Grant
- Administered By
- University of Tasmania
- Research Team
- Cook AL; Toh TY; Hewitt A; Eri RD
- Year
- 2014
- Description
- The aims of the project are: to study the expression levels of different inflammation molecules and inflammasome components in ulcerative colities patients, UC-associated-colorectal patients, sporadic colorectal patients compared to controls; to identify the cell populations where different inflammasome components are localised.
- Funding
- Clifford Craig Foundation ($24,409)
- Scheme
- Grant
- Administered By
- University of Tasmania
- Research Team
- Eri RD; Lloyd D; Mitchell B; Fanning S; Ahuja KDK; Cook AL
- Year
- 2014
- Funding
- Clifford Craig Foundation ($27,273)
- Scheme
- Grant
- Administered By
- University of Tasmania
- Research Team
- Cook AL; Eri RD; Hewitt A; Toh TY
- Year
- 2013
- Funding
- Clifford Craig Foundation ($54,546)
- Scheme
- Grant
- Administered By
- University of Tasmania
- Research Team
- Eri RD; Cook AL; Mitchell B; Wilson R
- Period
- 2013 - 2014
- Funding
- Australian Rotary Health Research Fund ($54,000)
- Scheme
- Scholarship-Funding Partners
- Administered By
- University of Tasmania
- Research Team
- Eri RD; Spring K; Cook AL
- Period
- 2013 - 2015
- Funding
- University of Tasmania ($2,460)
- Scheme
- Grant-Conference Support Scheme
- Administered By
- University of Tasmania
- Research Team
- Eri RD
- Year
- 2013
- Description
- The project aims to establish and bank glaucoma patient-specific fibroblast cell lines and conduct molecular analyses on these cell lines.
- Funding
- Centre for Eye Research Aust Ltd ($10,000)
- Scheme
- Contract Research
- Administered By
- University of Tasmania
- Research Team
- Cook AL; Eri RD
- Year
- 2012
- Funding
- University of Tasmania ($2,100)
- Scheme
- Grant-Conference Support Scheme
- Administered By
- University of Tasmania
- Research Team
- Eri RD
- Year
- 2011
- Funding
- National Health & Medical Research Council ($595,500)
- Scheme
- Grant-Project
- Administered By
- Mater Medical Research Institute
- Research Team
- Eri RD; Cook M; McKenzie BS; McGuckin MA; Florin THJ
- Period
- 2010 - 2012
- Grant Reference
- 604304
Research Supervision
Current
6
Completed
11
Current
| Degree | Title | Commenced |
|---|---|---|
| PhD | Fucoidan and its Effects on Inflammation | 2017 |
| PhD | Asperuloside Enhances Taste Perception, Decreases Inflammation and Prevents Weight Gain in High-fat Fed Mice | 2018 |
| PhD | Investigation of Early Predictors in Insulin Resistance and Type 2 Diabetes Mellitus | 2018 |
| PhD | Development and Assessment of Clinically Relevant Drugs for Disruption of Fear Memory Reconsolidation in Models of Post-traumatic Stress Disorder | 2018 |
| PhD | The Role of NLRP3 Inflammasome in Colitis-associated Colorectal Cancer | 2019 |
| PhD | The Relationship Between the Gut Microbiome, Pro-Inflammatory Biomarkers and Cognitive Dysfunction in Multiple Sclerosis | 2019 |
Completed
| Degree | Title | Completed |
|---|---|---|
| PhD | Efficacy of Short-Chain Quinones in Colitis: Future therapeutic options Candidate: Sonia Shastri | 2021 |
| Masters | Multi-system Pathophysiology and Molecular Signalling in a Ccr6-Deficient Murine Model of Spontaneous Colitis Candidate: Hewausaramba Ranmali Ranasinghe | 2020 |
| PhD | Synbiotic Efficacy of Probiotic and Prebiotic Food Ingredients for Gut Health Candidate: Tanvi Sandesh Shinde | 2019 |
| PhD | Investigating the Inner World of Stressed Goblet Cell Candidate: Rohit Gundamaraju | 2019 |
| PhD | Role of NLRP3 in Colitis and Colitis Associated Colorectal Cancer Candidate: Agampodi Promoda Prasadini Perera | 2019 |
| PhD | Investigation on the Utilization of Beneficial Microbes in Modulating the Gut Microbiota and Metabolic Profiles in Ageing Candidate: Ravichandra Vemuri | 2019 |
| PhD | Aqueous Humour Protein Imbalances in Primary Open-angle Glaucoma and Their Effects on Trabecular Meshwork Cell Function Candidate: Esther Lara Ashworth Briggs | 2018 |
| PhD | Inflammasome Activity in the Inflammatory Bowel Diseases Candidate: Nicole Maree Ranson | 2018 |
| PhD | Genetic Ablation of CCR6 Confers Differential Exacerbation in a Spontaneous Colitis Model Candidate: Waheedha Fathima Basheer | 2017 |
| PhD | Investigation of Neoplastic Transition of the Colonic Epithelium in the Winnie Mouse Model of Chronic Colitis Candidate: Sarron Yael Randall-Demllo | 2017 |
| Masters | In vitro Invasive Ability of X and V Factor Dependent Haemophilus Species Across Different Cell Types Candidate: Neeraj Kumar Singh | 2016 |