Profiles

Raj Eri

Associate Professor Raj Eri

Raj Eri

Associate Professor, Laboratory Medicine and Human Bioscience

Room 115 , C

+ 61 3 6324 5467 (phone)

+ 61 3 6324 5555 (fax)

Raj.Eri@utas.edu.au

Dr Eri was awarded a PhD in molecular biology by the University of Queensland in 2001 and continued to be a post-doc/senior scientist both in Australia and USA in the area of gut inflammation and immunology. In December 2010, he joined the University of Tasmania and established his independent group investigating topics in mucosal biology, establishing a national, and an emerging international, reputation in this area. Dr Eri also coordinates and teaches in the fields of immunology and biochemistry. Dr Eri's specific expertise includes simulation - to create virtual laboratories, technology enhanced learning, teaching-research nexus.

Dr Eri's research interests include the role of inflammasomes on bowel diseases and bowel cancer, early stage carcinogenesis pathways in colorectal cancer and the role of cytokines in inflammatory bowel disease (IBD) pathogenesis. His current research projects include inflammasomes in IBD, CCR6 in IBD pathogenesis, colorectal cancer pathways, heparin as anti-inflammatory agent in colitis, the role of bitter melon as anti-ER stress agent, and epidemiology of IBD in Tasmania.

Biography

CIA Eri (DVM, PhD) is a veterinarian turned biomedical scientist with an emerging international reputation in the field of mucosal biology/immunology. His research interests include understanding the role of inflammasomes, chemokines (CCR6 and CCL20), IL-23/TH17 pathways in both murine and human IBD. Additionally, Dr Eri conducts research into the efficacy of natural products (bitter melon, raw banana, yogurt) in the treatment of IBD and a number pf pre-clinical studies are being carried in that direction.

His recent research interests include colorectal cancer and respiratory diseases such as asthma and COPD. Previously he was a senior research officer at the Mater Medical Research Institute (MMRI, now TRI, Brisbane). During this time he was chief investigator on 3 NHMRC and 1 Queensland Cancer Fund applications and was instrumental in providing ground breaking identification of ER stress in the pathogenesis of IBD. His PhD was awarded in 2001 from the University of Queensland and the initial post-doctoral work in mucosal immunology area was conducted in UCLA, USA. Since 2011, Dr Eri has established an independent laboratory at UTAS. Even as a 40:40:20 academic at UTAS, he has maintained a very productive research career as evidenced from publications (20), grants (6) and graduate students (5) during that period. The collective impact of CIA Eri's contribution is highlighted by numerous worldwide collaborations with clinicians and researchers, invitations to speak at international meetings, invited reviews, as well as editorial and refereeing work. To cite a few examples, he was invited to edit an edition of Frontiers in Immunology, organised and chaired sessions at Gastroenterological Society of Australia (GESA) annual meetings, invited to speak at a number of conferences in Australia. He published in prestigious journals (PLoS medicine, J Exp Med, Gut, BMJ). His work is widely cited (a total of ~ 1500 citations) with an average of more than 26 citations/paper and more than 350 citations for the highest cited paper.

Career summary

Qualifications

PhD, University of Queensland, Australia, 2001
M V Sc, TN Veterinary and Animal Sciences University, India, 1994
B V Sc, TN Veterinary and Animal Sciences University, India, 1990
Grad Cert T&L, University of Tasmania, 2012

Languages (other than English)

Hindi
Tamil
Esperanto
Telugu
Kannada

Memberships

Professional practice

Australian Society for Medical Research (ASMR)- President-Tasmania: Three years of organizing Medical Research Week in Tasmania
NHMRC grants assessor: NHMRC has requested to review project grants for 2010-13. So far, assessed 6 grants
Manuscript Reviewer: 10 Journals including American Journal of Physiology (Gastro), Journal of Cellular Biochemistry, PLoS One etc.
MMRI student committee member: specially in-charge of recruitment: Organised MMRI student open days and also attended recruitment expos at UQ, QUT to attract students
MMRI seminar series coordinator: Arranged speakers every week for MMRI seminar series and coordinated the seminars- 2008
MMRI science week committee member: Part of national science week celebrations educating students and public from various parts of Queensland through public lectures – 2008-09
MMRI statistical task force member: Part of the committee that decides on statistical requirements for the institute
ASMR Queensland Premier's Award Committee member: Organising member for the prestigious awards for the last 4 years
Australasian Society for Immunology (ASI): Member for organising the national conference for 2009 at the Gold Coast
Organising Committee member for ASI-FIMSA: an advanced course in immunology 2009

Administrative expertise

Managed NHMRC research project as CIA
Graduate research coordination

Teaching

Teaching expertise

Raj has a strong commitment to strategies that bridge research and teaching by incorporating research principles into classroom teaching. He has introduced adaptive eLearning methods to augment student skills for better learning outcomes. His determination to motivate students to be independent learners has proven his excellence in teaching as evidenced by SETL/eVALUate/feedback from students and peers.

Raj has also been involved in a number of educational research projects (including investigator in 3 TDGs) & published 4 papers so far. He has an active commitment to the Tasmanian community.

Teaching responsibility

View more on AssocProf Raj Eri in WARP

Expertise

Chronic Inflammation
ER stress
Pathogenesis of inflammatory Bowel Disease
Gut Health
Pre-clinical models of gut health
Inflammasomes

Research Themes

Raj's research aligns to the University's research theme of Better Health. He has significant expertise in the fields of colitis and IBD that includes a multitude of animal models of colitis. Furthermore he was the first to describe the ER stress induced molecular pathology of a novel murine model of spontaneous colitis-Winnie. All the clinical, histological, immunological and immuno-histochemical methods have been optimised and being in current use in his research laboratory.

Overall, Raj has published over 25 papers and reviews in this specific field in high ranking journals in the areas of the role of ER stress, the pre-clinical efficacy of a number of food products/peptides/cytokines for the treatment of colitis.

Raj was specifically recruited to UTAS as a 'research active' academic. He has established a mucosal biology laboratory and already recruited many Honours/PhD students in his projects. He is trying to establish a niche for himself in the mucosal immunology area and is uniquely positioned as only one of a very few dedicated mucosal immunology researchers in Australia. His vision is to conduct high-quality research in the areas of chronic intestinal inflammation & colorectal cancer and contribute towards a better understanding of IBD pathogenesis and treatment. Furthermore, he would also like to conduct basic research in the area cell stress and apoptosis specifically in the intestinal epithelial cells. In addition to his science research, Raj has a keen interest in educational research as well. To this end, he currently holds a teaching development grant from UTAS.

Collaboration

Prof Heinrich Korner - MRIT and University of Tasmania
Assoc Prof Nuri Guven - School of Pharmacy, University of Tasmania
Dr Rahul Patel - School of Pharmacy, University of Tasmania
Dr Lana Shabala - School of Agriculture, University of Tasmania
Dr Christine Booth - DSTO, Scottsdale
Dr Kulmira Nurgali - Victoria University, Melbourne
Drs Brent Mitchell, Scott Fanning, Ray Wilson - Launceston General Hospital
Dr Prathiba Nerurkar - University of Hawaii, U.S.A.
Dr Marcello Chieppa - Bari University, Italy
Prof Mike McGuckin - Mater Medical Research Institute/TRI, University of Queensland, Brisbane

Awards

Winner, rapid Research, UTAS, 2012
Finalist, Queensland Premier's Award for Medical Research, Senior category, 2010
UQ Reginald Ferguson fellowship in Gastroenterology Research, 2007
UQ Reginald Ferguson fellowship in Gastroenterology Research, 2006
Indiana University post-doctoral fellowship, USA, 2004
Queensland Protein Group best oral presentation award, 2000
Finalist, Young Investigator Award, Gastroenterology Week, Sydney, 2002
QIMR cancer unit PhD scholarship, 1999
Best Thesis Award - MVSc thesis - Veterinary Medicine, 1996

Current projects

The hierarchial activation of inflammasomes in chronic colitis
Inflammasomes are protein complexes that are implicated in initiation of many diseases including inflammatory bowel disease (IBD). In my laboratory, we have characterised a mouse model that develops spontaneous colitis similar to human colitis. We have a strong indication from human studies that specific inflammasomes are activated in IBD. In this mouse model, we want to explore functional studies as to how inflammasome contributes to pathogenesis of IBD.
Characterisation of flat dysplasia in colitis associated colorectal cancer
Patients with ulcerative colitis are at increased risk of developing colorectal cancer. Colitis-associated colorectal cancer (CACC) progresses through similar stepwise gene mutations observed in sporadic cancers, but the sequence in which they occur is reversed. Understanding the transition from colitis to tumour requires relevant animal models. Colonic carcinogenesis has been modelled using genotoxic carcinogens such as azoxymethane. We hypothesise that exacerbation of pre-existing chronic colitis in a Muc2 mutant (Winnie) mouse strain with dextran sulphate sodium (DSS) would induce colorectal tumorigenesis.
CCR6 deficiency aggravates colitis in a spontaneous colitis model
Chemokine receptor 6 (CCR6) and its ligand CCL20 is implicated to play a major role in IBD pathogenesis. The CCR6/CCL20 axis is involved in both immune regulation and activation. CCR6 is expressed by both pro-inflammatory cells and regulatory T cells elucidate the dual role of the receptor. The contradictory role of CCR6/CCL20 in inflammation/homeostasis requires further research.

Fields of Research

Genetic immunology (310507)
Pharmaceutical sciences (321405)
Cell development, proliferation and death (310102)
Animal physiology - systems (310910)
Gastroenterology and hepatology (320209)
Cellular immunology (320404)
Respiratory diseases (320103)
Immunology (320499)
Cell neurochemistry (310104)
Nutritional science (321004)
Pharmacology and pharmaceutical sciences (321499)
Medical bacteriology (320701)
Ophthalmology and optometry (321299)
Nutrition and dietetics (321099)
Higher education (390303)
Signal transduction (310111)
Cell metabolism (310103)
Innate immunity (320407)
Biochemistry and cell biology (310199)
Rheumatology and arthritis (320223)
Microbial ecology (310703)
Community child health (420601)
Mental health services (420313)
Cancer cell biology (321101)
Animal physiology - cell (310909)
Haematological tumours (321106)
Central nervous system (320903)
Haematology (320102)
Health and community services (420305)
Clinical pharmacology and therapeutics (321402)
Infectious agents (310702)
Cardiology (incl. cardiovascular diseases) (320101)
Animal physiology - biophysics (310908)
Aboriginal and Torres Strait Islander public health and wellbeing (450417)
Traditional, complementary and integrative medicine (420899)
Fine arts (360602)
Microbiology (310799)
Occupational and workplace health and safety (350505)
Geriatrics and gerontology (320210)
Bacteriology (310701)
Science, technology and engineering curriculum and pedagogy (390113)
Cancer diagnosis (321102)
Receptors and membrane biology (310110)
Metabolic medicine (320507)
Health services and systems (420399)
Education assessment and evaluation (390402)
Vision science (321204)
Medical biochemistry and metabolomics (320599)
Exercise physiology (420702)
Epigenetics (incl. genome methylation and epigenomics) (310504)
Genomics (310509)
Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies) (320402)
Genetics (310599)
Behavioural neuroscience (520202)
Psychiatry (incl. psychotherapy) (320221)
Cellular nervous system (320902)
Health care administration (420306)
Human information interaction and retrieval (461003)
Clinical pharmacy and pharmacy practice (321403)
Visual arts (360699)
Traditional Chinese medicine and treatments (420803)
Sport and exercise nutrition (321006)
Pharmacogenomics (321406)
Food nutritional balance (300603)
Cognition (520401)
Sports science and exercise (420799)
Cell physiology (320801)
Medical biochemistry - nucleic acids (320505)
Food properties (incl. characteristics and health benefits) (321002)
Medical biotechnology (320699)
Cancer genetics (321103)
Infectious diseases (320211)
Food engineering (400405)
Tumour immunology (320409)

Research Objectives

Clinical health (200199)
Expanding knowledge in the health sciences (280112)
Diagnosis of human diseases and conditions (200101)
Public health (excl. specific population health) (200499)
Expanding knowledge in the biological sciences (280102)
Other health (209999)
Human pharmaceutical treatments (240803)
Human pharmaceutical products (240899)
Disease distribution and transmission (incl. surveillance and response) (200404)
Learner and learning (160199)
Health status (incl. wellbeing) (200407)
Preventive medicine (200412)
Other education and training (169999)
Expanding knowledge in the environmental sciences (280111)
Prevention of human diseases and conditions (200104)
Teaching and instruction technologies (160304)
Workforce transition and employment (160206)
The creative arts (130103)
Injury prevention and control (200408)
Plant extracts (241403)
Nursing (200307)
Mental health services (200305)
Neonatal and child health (200506)
Nutraceuticals and functional foods (241308)
Personnel (140110)
Social structure and health (200207)
Human biological preventatives (240801)
Women's and maternal health (200509)
Nutrition (200410)
Emerging defence technologies (140104)
Aboriginal and Torres Strait Islander determinants of health (210301)

Publications

The collective impact of CIA Eri's contribution is highlighted by numerous worldwide collaborations with clinicians and researchers, invitations to speak at international meetings, invited reviews, as well as editorial and refereeing work. To cite a few examples, he was invited to edit an edition of Frontiers in Immunology, organised and chaired sessions at Gastroenterological Society of Australia (GESA) annual meetings, invited to speak at a number of conferences in Australia. He published in prestigious journals (PLoS medicine, J Exp Med, Gut, BMJ). His work is widely cited (a total of ~ 1500 citations) with an average of more than 26 citations/paper and more than 350 citations for the highest cited paper.

Total publications

102

Highlighted publications

(7 outputs)

Year	Type	Citation
2015	Journal Article	Wang R, Hasnain SZ, Tong H, Das I, Che-Hao Chen A, et al., 'Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model', Inflammatory Bowel Diseases, 21, (5) pp. 973-84. ISSN 1078-0998 (2015) [Refereed Article] DOI: 10.1097/MIB.0000000000000353 [eCite] [Details] Citations: Scopus - 19Web of Science - 18 Tweet
2014	Journal Article	Alkadhi S, Kunde D, Cheluvappa R, Randall-Demllo S, Eri R, 'The murine appendiceal microbiome is altered in spontaneous colitis and its pathological progression', Gut pathogens, 6 Article 25. ISSN 1757-4749 (2014) [Refereed Article] DOI: 10.1186/1757-4749-6-25 [eCite] [Details] Citations: Scopus - 23Web of Science - 22 Co-authors: Kunde D; Randall-Demllo S Tweet
2013	Journal Article	Das I, Png CW, Oancea I, Hasnain SZ, Lourie R, et al., 'Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins', The Journal of Experimental Medicine, 210, (6) pp. 1201-1216. ISSN 0022-1007 (2013) [Refereed Article] DOI: 10.1084/jem.20121268 [eCite] [Details] Citations: Scopus - 57Web of Science - 57 Tweet
2013	Journal Article	Oancea I, Png CW, Das I, Lourie R, Winkler I, et al., 'A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity', Gut: An International Journal of Gastroenterology and Hepatology, 62, (4) pp. 594-605. ISSN 0017-5749 (2013) [Refereed Article] DOI: 10.1136/gutjnl-2012-302274 [eCite] [Details] Citations: Scopus - 38Web of Science - 39 Tweet
2008	Journal Article	Eri RD, Heazlewood CK, Cook MC, Price GR, Tauro SB, et al., 'Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis', PLoS Med, 5, (3) pp. E54. ISSN 1549-1676 (2008) [Refereed Article] DOI: 10.1371/journal.pmed.0050054 [eCite] [Details] Citations: Scopus - 464Web of Science - 445 Tweet
2005	Journal Article	Fukata M, Michelsen KS, Eri RD, Thomas LS, Hu B, et al., 'Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis', American Journal of Physiology: Gastrointestinal and Liver Physiology, 288, (5) pp. 1055-1065. ISSN 0193-1857 (2005) [Refereed Article] DOI: 10.1152/ajpgi.00328.2004 [eCite] [Details] Citations: Scopus - 401Web of Science - 368 Tweet
1999	Journal Article	Eri RD, Arnold J, Hinman V, Green K, Jones M, et al., 'Hemps, a novel EGF-like protein plays a central role in ascidian metamorphosis', Development (Cambridge), 126, (24) pp. 5809-5818 . ISSN 0950-1991 (1999) [Refereed Article] [eCite] [Details] Citations: Web of Science - 57

Journal Article

(82 outputs)

Year	Citation	Altmetrics
2021	Gueven N, Ravishankar P, Eri RD, Rybalka E, 'Idebenone: when an antioxidant is not an antioxidant', Redox Biology, 38 Article 101812. ISSN 2213-2317 (2021) [Refereed Article] DOI: 10.1016/j.redox.2020.101812 [eCite] [Details] Co-authors: Gueven N; Ravishankar P Tweet
2020	Beckett JM, Singh NK, Phillips J, Kalpurath K, Taylor K, et al., 'Anti-heartburn effects of sugar cane flour: A double-blind, randomized, placebo-controlled study', Nutrients, 12 pp. 1-9. ISSN 2072-6643 (2020) [Refereed Article] DOI: 10.3390/nu12061813 [eCite] [Details] Citations: Scopus - 1Web of Science - 1 Co-authors: Beckett JM; Singh NK; Stanley RA Tweet
2020	Clarke LJ, Jones PJ, Ammitzboll H, Barmuta LA, Breed MF, et al., 'Mainstreaming microbes across biomes', Bioscience, 70, (7) pp. 589-596. ISSN 0006-3568 (2020) [Refereed Article] DOI: 10.1093/biosci/biaa057 [eCite] [Details] Citations: Scopus - 2Web of Science - 2 Co-authors: Clarke LJ; Jones PJ; Ammitzboll H; Barmuta LA; Charleston M; Dakwa V; Fountain-Jones NM; Kendal D; Sow SLS; Vemuri R; Flies EJ Tweet
2020	Gundamaraju R, Lu W, Azimi I, Eri R, Sohal SS, 'Endogenous anti-cancer candidates in GPCR, ER stress, and EMT', Biomedicines, 8, (10) pp. 1-13. ISSN 2227-9059 (2020) [Refereed Article] DOI: 10.3390/biomedicines8100402 [eCite] [Details] Citations: Scopus - 1Web of Science - 1 Co-authors: Lu W; Azimi I; Sohal SS Tweet
2020	Guven N, Spring KJ, Holmes S, Ahuja K, Eri R, et al., 'Micro RNA expression after ingestion of fucoidan; a clinical study', Marine Drugs, 18, (3) pp. 1-11. ISSN 1660-3397 (2020) [Refereed Article] DOI: 10.3390/md18030143 [eCite] [Details] Citations: Scopus - 3Web of Science - 2 Co-authors: Guven N; Holmes S; Ahuja K Tweet
2020	Liso M, De Santis S, Verna G, Dicarlo M, Calasso M, et al., 'A specific mutation in Muc2 determines early dysbiosis in colitis-prone Winnie mice', Inflammatory Bowel Diseases, 26, (4) pp. 546-556. ISSN 1078-0998 (2020) [Refereed Article] DOI: 10.1093/ibd/izz279 [eCite] [Details] Citations: Scopus - 7Web of Science - 8 Tweet
2020	Ngui IQH, Perera AP, Eri R, 'Does NLRP3 inflammasome and aryl hydrocarbon receptor play an interlinked role in bowel inflammation and colitis-associated colorectal cancer?', Molecules, 25, (10) pp. 1-25. ISSN 1420-3049 (2020) [Refereed Article] DOI: 10.3390/molecules25102427 [eCite] [Details] Citations: Scopus - 5Web of Science - 3 Co-authors: Perera AP Tweet
2020	Ranasinghe R, Fernando R, Perera AP, Shastri M, Basheer W, et al., 'Ccr6 Deficiency attenuates spontaneous chronic colitis in Winnie', Gastrointestinal Disorders, 2 pp. 27-47. ISSN 2624-5647 (2020) [Refereed Article] DOI: 10.3390/gidisord2010004 [eCite] [Details] Co-authors: Perera AP; Shastri M; Basheer W; Scowen P; Pinfold T Tweet
2020	Sahakian L, Filippone RT, Stavely R, Robinson AM, Yan XS, et al., 'Inhibition of APE1/Ref-1 redox signaling alleviates intestinal dysfunction and damage to myenteric neurons in a mouse model of spontaneous chronic colitis', Inflammatory Bowel Diseases, 27, (3) pp. 388-406. ISSN 1078-0998 (2020) [Refereed Article] DOI: 10.1093/ibd/izaa161 [eCite] [Details] Citations: Scopus - 1Web of Science - 59 Tweet
2020	Shastri MD, Chong WC, Vemuri R, Martoni CJ, Adhikari S, et al., 'Streptococcus thermophilus UASt-09 upregulates goblet cell activity in colonic epithelial cells to a greater degree than other probiotic strains', Microorganisms, 8, (11) pp. 1-15. ISSN 2076-2607 (2020) [Refereed Article] DOI: 10.3390/microorganisms8111758 [eCite] [Details] Co-authors: Shastri MD; Chong WC; Vemuri R; Kunde D; Tristram SG Tweet
2020	Shastri S, Shinde T, Perera AP, Gueven N, Eri R, 'Idebenone protects against spontaneous chronic murine colitis by alleviating endoplasmic reticulum stress and inflammatory response', Biomedicines, 8, (10) Article 384. ISSN 2227-9059 (2020) [Refereed Article] DOI: 10.3390/biomedicines8100384 [eCite] [Details] Citations: Scopus - 1Web of Science - 1 Co-authors: Perera AP; Gueven N Tweet
2020	Shastri S, Shinde T, Sohal SS, Gueven N, Eri R, 'Idebenone Protects against Acute Murine Colitis via Antioxidant and Anti-Inflammatory Mechanisms', International Journal of Molecular Sciences, 21, (2) pp. 1-21. ISSN 1422-0067 (2020) [Refereed Article] DOI: 10.3390/ijms21020484 [eCite] [Details] Citations: Scopus - 4Web of Science - 5 Co-authors: Sohal SS; Gueven N Tweet
2020	Shinde T, Hansbro PM, Sohal SS, Dingle P, Eri R, et al., 'Microbiota modulating nutritional approaches to countering the effects of viral respiratory infections including SARS-CoV-2 through promoting metabolic and immune fitness with probiotics and plant bioactives', Microorganisms, 8, (6) Article 921. ISSN 2076-2607 (2020) [Refereed Article] DOI: 10.3390/microorganisms8060921 [eCite] [Details] Citations: Scopus - 19Web of Science - 17 Co-authors: Sohal SS; Stanley R Tweet
2020	Shinde T, Perera AP, Vemuri R, Gondalia SV, Beale DJ, et al., 'Synbiotic supplementation with prebiotic green banana resistant starch and probiotic Bacillus coagulans spores ameliorates gut inflammation in mouse model of inflammatory bowel diseases', European Journal of Nutrition, 59, (8) pp. 3669-3689. ISSN 1436-6207 (2020) [Refereed Article] DOI: 10.1007/s00394-020-02200-9 [eCite] [Details] Citations: Scopus - 10Web of Science - 11 Co-authors: Perera AP; Vemuri R; Basheer W; Southam B; Stanley R Tweet
2020	Vemuri R, Shankar EM, Chieppa M, Eri R, Kavanagh K, 'Beyond just bacteria: Functional biomes in the gut ecosystem including virome, mycobiome, archaeome and helminths', Microorganisms, 8, (4) pp. 1-24. ISSN 2076-2607 (2020) [Refereed Article] DOI: 10.3390/microorganisms8040483 [eCite] [Details] Citations: Scopus - 21Web of Science - 16 Tweet
2019	Corban M, Ambrose M, Pagnon J, Stringer D, Karpiniec S, et al., 'Pathway analysis of fucoidan activity using a yeast gene deletion library screen', Marine drugs, 17, (1) Article 54. ISSN 1660-3397 (2019) [Refereed Article] DOI: 10.3390/md17010054 [eCite] [Details] Citations: Scopus - 5Web of Science - 5 Co-authors: Corban M; Ambrose M; Fitton JH; Gueven N Tweet
2019	Eri R, Gudimetla P, Vemuri R, 'Beyond the technical skills: a case for internationalization of graduate attributes in PhD programs', Universal Journal of Educational Research, 7, (3) pp. 766-771. ISSN 2332-3205 (2019) [Refereed Article] DOI: 10.13189/ujer.2019.070316 [eCite] [Details] Tweet
2019	Flies EJ, Mavoa S, Zosky GR, Mantzioris E, Williams C, et al., 'Urban-associated diseases: candidate diseases, environmental risk factors, and a path forward', Environment International, 133, (Part A) Article 105187. ISSN 0160-4120 (2019) [Refereed Article] DOI: 10.1016/j.envint.2019.105187 [eCite] [Details] Citations: Scopus - 21Web of Science - 16 Co-authors: Flies EJ; Zosky GR; Brook BW; Buettel JC Tweet
2019	Gundamaraju R, Vemuri R, Chong WC, Bulmer AC, Eri R, 'Bilirubin attenuates ER Stress-Mediated Inflammation, escalates Apoptosis and reduces Proliferation in the LS174T Colonic Epithelial Cell Line', International journal of medical sciences, 16, (1) pp. 135-144. ISSN 1449-1907 (2019) [Refereed Article] DOI: 10.7150/ijms.29134 [eCite] [Details] Citations: Scopus - 9Web of Science - 9 Co-authors: Vemuri R; Chong WC Tweet
2019	Ranson N, Veldhuis M, Mitchell B, Fanning S, Cook AL, et al., 'NLRP3-dependent and -independent processing of interleukin (IL)-1β in active ulcerative colitis', International Journal of Molecular Sciences, 20, (1) pp. 1-15. ISSN 1422-0067 (2019) [Refereed Article] DOI: 10.3390/ijms20010057 [eCite] [Details] Citations: Scopus - 18Web of Science - 15 Co-authors: Ranson N; Cook AL; Kunde D Tweet
2019	Shinde T, Perera AP, Vemuri R, Gondalia SV, Karpe AV, et al., 'Synbiotic supplementation containing whole plant sugar cane Fibre and probiotic spores potentiates protective synergistic effects in mouse model of IBD', Nutrients, 11, (4) Article 818. ISSN 2072-6643 (2019) [Refereed Article] DOI: 10.3390/nu11040818 [eCite] [Details] Citations: Scopus - 23Web of Science - 23 Co-authors: Perera AP; Vemuri R; Shastri M; Southam BT; Stanley R Tweet
2019	Shinde T, Vemuri R, Shastri MD, Perera AP, Tristram S, et al., 'Probiotic Bacillus coagulans MTCC 5856 spores exhibit excellent in-vitro functional efficacy in simulated gastric survival, mucosal adhesion and immunomodulation', Journal of Functional Foods, 52 pp. 100-108. ISSN 1756-4646 (2019) [Refereed Article] DOI: 10.1016/j.jff.2018.10.031 [eCite] [Details] Citations: Scopus - 14Web of Science - 11 Co-authors: Vemuri R; Shastri MD; Perera AP; Tristram S; Stanley R Tweet
2019	Shukla SD, Shastri MD, Chong WC, Dua K, Budden KF, et al., 'Microbiome-focused asthma management strategies', Current Opinion in Pharmacology, 46 pp. 143-149. ISSN 1471-4892 (2019) [Refereed Article] DOI: 10.1016/j.coph.2019.06.003 [eCite] [Details] Citations: Scopus - 5Web of Science - 5 Co-authors: Shastri MD; Mahmood MQ; Patel RP; Peterson GM Tweet
2019	Vemuri R, Gundamaraju R, Shinde T, Perera AP, Basheer W, et al., 'Lactobacillus acidophilus DDS-1 modulates intestinal-specific microbiota, short-chain fatty acid and immunological profiles in aging mice', Nutrients, 11, (6) pp. 1-23. ISSN 2072-6643 (2019) [Refereed Article] DOI: 10.3390/nu11061297 [eCite] [Details] Citations: Scopus - 15Web of Science - 14 Co-authors: Vemuri R; Perera AP; Basheer W; Southam B; Tristram S; Ahuja KDK Tweet
2019	Wilson R, Gundamaraju R, Vemuri R, Angelucci C, Geraghty D, et al., 'Identification of key pro-survival proteins in isolated colonic goblet cells of Winnie, a murine model of spontaneous colitis', Inflammatory Bowel Diseases, 26, (1) pp. 80-92. ISSN 1536-4844 (2019) [Refereed Article] DOI: 10.1093/ibd/izz179 [eCite] [Details] Citations: Scopus - 2Web of Science - 16 Co-authors: Wilson R; Vemuri R; Angelucci C; Geraghty D; Guven N Tweet
2018	Ashworth Briggs EL, Toh T, Eri R, Hewitt AW, Cook AL, 'Uteroglobin and FLRG concentrations in aqueous humor are associated with age in primary open angle glaucoma patients', BMC Ophthalmology, 18, (1) pp. 1-8. ISSN 1471-2415 (2018) [Refereed Article] DOI: 10.1186/s12886-018-0723-4 [eCite] [Details] Citations: Scopus - 1Web of Science - 1 Co-authors: Ashworth Briggs EL; Hewitt AW; Cook AL Tweet
2018	Gundamaraju R, Vemuri R, Chong WC, Myers S, Norouzi S, et al., 'Interplay between Endoplasmic Reticular Stress and Survivin in Colonic Epithelial Cells', Cells, 7, (10) Article 171. ISSN 2073-4409 (2018) [Refereed Article] DOI: 10.3390/cells7100171 [eCite] [Details] Citations: Web of Science - 7 Co-authors: Vemuri R; Chong WC; Myers S; Norouzi S; Shastri MD Tweet
2018	Perera AP, Fernando R, Shinde T, Gundamaraju R, Southam B, et al., 'MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice', Scientific Reports, 8 Article 8618. ISSN 2045-2322 (2018) [Refereed Article] DOI: 10.1038/s41598-018-26775-w [eCite] [Details] Citations: Scopus - 101Web of Science - 99 Co-authors: Perera AP; Southam B; Sohal SS; Kunde D Tweet
2018	Perera AP, Sajnani K, Dickinson J, Eri R, Korner H, 'NLRP3 inflammasome in colitis and colitis-associated colorectal cancer', Mammalian Genome, 29, (11-12) pp. 817-830. ISSN 0938-8990 (2018) [Refereed Article] DOI: 10.1007/s00335-018-9783-2 [eCite] [Details] Citations: Scopus - 19Web of Science - 3 Co-authors: Perera AP; Dickinson J; Korner H Tweet
2018	Ranasinghe R, Eri R, 'Pleiotropic immune functions of chemokine receptor 6 in health and disease', Medicines, 5, (3) Article 69. ISSN 2305-6320 (2018) [Refereed Article] DOI: 10.3390/medicines5030069 [eCite] [Details] Tweet
2018	Ranson N, Veldhuis M, Mitchell B, Fanning S, Cook AL, et al., 'Nod-like receptor pyrin-containing protein 6 (NLRP6) is up-regulated in ileal Crohn's disease and differentially expressed in goblet cells', Cellular and Molecular Gastroenterology and Hepatology, 6, (1) pp. 110-112. ISSN 2352-345X (2018) [Refereed Article] DOI: 10.1016/j.jcmgh.2018.03.001 [eCite] [Details] Citations: Scopus - 10Web of Science - 10 Co-authors: Ranson N; Cook AL; Kunde D Tweet
2018	Shastri MD, Shukla SD, Chong WC, Dua K, Peterson GM, et al., 'Role of oxidative stress in the pathology and management of human tuberculosis', Oxidative Medicine and Cellular Longevity, 2018 Article 7695364. ISSN 1942-0900 (2018) [Refereed Article] DOI: 10.1155/2018/7695364 [eCite] [Details] Citations: Scopus - 32Web of Science - 33 Co-authors: Shastri MD; Peterson GM; Patel RP; O'Toole RF Tweet
2018	Vemuri R, Gundamaraju R, Shastri MD, Shukla SD, Kalpurath K, et al., 'Gut microbial changes, interactions, and their implications on human lifecycle: An ageing perspective', BioMed Research International, 2018 Article 4178607. ISSN 2314-6133 (2018) [Refereed Article] DOI: 10.1155/2018/4178607 [eCite] [Details] Citations: Scopus - 36Web of Science - 39 Co-authors: Vemuri R; Shastri MD; Shukla SD; Tristram S; Ahuja K Tweet
2018	Vemuri R, Shinde T, Gundamaraju R, Gondalia SV, Karpe AV, et al., 'Lactobacillus acidophilus DDS-1 modulates the gut microbiota and improves metabolic profiles in aging mice', Nutrients, 10, (9) Article 1255. ISSN 2072-6643 (2018) [Refereed Article] DOI: 10.3390/nu10091255 [eCite] [Details] Citations: Scopus - 21Web of Science - 21 Co-authors: Vemuri R Tweet
2018	Vemuri R, Shinde T, Shastri MD, Perera AP, Tristram S, et al., 'A human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics', International Journal of Medical Sciences, 15, (9) pp. 840-848. ISSN 1449-1907 (2018) [Refereed Article] DOI: 10.7150/ijms.25004 [eCite] [Details] Citations: Scopus - 15Web of Science - 15 Co-authors: Vemuri R; Shastri MD; Perera AP; Tristram S; Ahuja KDK Tweet
2018	Vemuri R, Sylvia KE, Klein SL, Forster SC, Plebanski M, et al., 'The microgenderome revealed: sex differences in bidirectional interactions between the microbiota, hormones, immunity and disease susceptibility', Seminars in Immunopathology, 41, (2) pp. 265-275. ISSN 1863-2297 (2018) [Refereed Article] DOI: 10.1007/s00281-018-0716-7 [eCite] [Details] Citations: Scopus - 53Web of Science - 51 Co-authors: Vemuri R; Plebanski M; Flanagan KL Tweet
2017	De Santis S, Kunde D, Galleggiante V, Liso M, Scandiffio L, et al., 'TNFα deficiency results in increased IL-1β in an early onset of spontaneous murine colitis', Cell Death and Disease, 8, (8) pp. 1-7. ISSN 2041-4889 (2017) [Refereed Article] DOI: 10.1038/cddis.2017.397 [eCite] [Details] Citations: Scopus - 9Web of Science - 9 Co-authors: Kunde D Tweet
2017	Kunde DA, Chong WC, Nerurkar PV, Ahuja KDK, Just J, et al., 'Bitter melon protects against ER stress in LS174T colonic epithelial cells', BMC Alternative Medicine, 17 Article 2. ISSN 1472-6882 (2017) [Refereed Article] DOI: 10.1186/s12906-016-1522-1 [eCite] [Details] Citations: Scopus - 7Web of Science - 7 Co-authors: Kunde DA; Chong WC; Ahuja KDK; Just J; Smith JA; Guven N Tweet
2017	Perera AP, Kunde D, Eri R, 'NLRP3 inhibitors as potential therapeutic agents for treatment of inflammatory bowel disease', Current Pharmaceutical Design, 23, (16) pp. 2321-2327. ISSN 1381-6128 (2017) [Refereed Article] DOI: 10.2174/1381612823666170201162414 [eCite] [Details] Citations: Scopus - 28Web of Science - 19 Co-authors: Perera AP; Kunde D Tweet
2017	Robinson AM, Rahman AA, Carbone SE, Randall-Demllo S, Filippone R, et al., 'Alterations of colonic function in the Winnie mouse model of spontaneous chronic colitis', AJP: Gastrointestinal and Liver Physiology, 312, (1) pp. G85-G102. ISSN 1522-1547 (2017) [Refereed Article] DOI: 10.1152/ajpgi.00210.2016 [eCite] [Details] Citations: Scopus - 17Web of Science - 15 Co-authors: Randall-Demllo S Tweet
2017	Vemuri RC, Gundamaraju R, Shinde T, Eri R, 'Therapeutic interventions for gut dysbiosis and related disorders in the elderly: Antibiotics, probiotics or faecal microbiota transplantation?', Beneficial Microbes, 8, (2) pp. 179-192. ISSN 1876-2883 (2017) [Refereed Article] DOI: 10.3920/BM2016.0115 [eCite] [Details] Citations: Scopus - 28Web of Science - 28 Co-authors: Vemuri RC Tweet
2016	Booth C, Cheluvappa R, Bellinson Z, Maguire D, Zimitat C, et al., 'Empirical evaluation of a virtual laboratory approach to teach lactate dehydrogenase enzyme kinetics', Annals of Medicine and Surgery, 8 pp. 6-13. ISSN 2049-0801 (2016) [Refereed Article] DOI: 10.1016/j.amsu.2016.04.019 [eCite] [Details] Citations: Scopus - 8Web of Science - 5 Co-authors: Booth C; Zimitat C Tweet
2016	De Santis S, Kunde D, Serino G, Galleggiante V, Caruso ML, et al., 'Secretory leukoprotease inhibitor is required for efficient quercetin-mediated suppression of TNFα secretion', Oncotarget, 7, (46) pp. 75800-75809. ISSN 1949-2553 (2016) [Refereed Article] DOI: 10.18632/oncotarget.12415 [eCite] [Details] Citations: Scopus - 24Web of Science - 22 Co-authors: Kunde D; Ranson N Tweet
2016	Douglas T, Salter S, Iglesias M, Dowlman M, Eri R, 'The feedback process: Perspectives of first and second year undergraduate students in the disciplines of education, health science and nursing', Journal of University Teaching & Learning Practice, 13, (1) Article 3. ISSN 1449-9789 (2016) [Refereed Article] [eCite] [Details] Citations: Web of Science - 8 Co-authors: Douglas T; Salter S; Iglesias M; Dowlman M Tweet
2016	Gundamaraju R, Vemuri R, Eri R, 'Overriding Elements in Colon Cancer Progression: Some Less Known Facts', Gastro, 2, (1) pp. 4-8. ISSN 2377-8369 (2016) [Contribution to Refereed Journal] DOI: 10.17140/GOJ-2-124 [eCite] [Details] Co-authors: Vemuri R Tweet
2016	Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, et al., 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)', Autophagy, 12, (1) pp. 1-222. ISSN 1554-8627 (2016) [Refereed Article] DOI: 10.1080/15548627.2015.1100356 [eCite] [Details] Citations: Scopus - 3280Web of Science - 3758 Co-authors: Randall-Demllo S Tweet
2016	Rahman AA, Robinson AM, Brookes SJH, Eri R, Nurgali K, 'Rectal prolapse in Winnie mice with spontaneous chronic colitis: changes in intrinsic and extrinsic innervation of the rectum', Cell and Tissue Research, 366, (2) pp. 285-299. ISSN 0302-766X (2016) [Refereed Article] DOI: 10.1007/s00441-016-2465-z [eCite] [Details] Citations: Scopus - 9Web of Science - 9 Tweet
2016	Randall-Demllo S, Fernando R, Brain T, Sohal SS, Cook AL, et al., 'Characterisation of colonic dysplasia-like epithelial atypia in murine colitis', World Journal of Gastroenterology, 22, (37) pp. 8334-8348. ISSN 1007-9327 (2016) [Refereed Article] DOI: 10.3748/wjg.v22.i37.8334 [eCite] [Details] Citations: Scopus - 7Web of Science - 7 Co-authors: Randall-Demllo S; Sohal SS; Cook AL; Guven N; Kunde D Tweet
2016	Robinson AM, Gondalia SV, Karpe AV, Eri R, Beale DJ, et al., 'Fecal microbiota and metabolome in a mouse model of spontaneous chronic colitis: relevance to human inflammatory bowel disease', Inflammatory Bowel Diseases, 22, (12) pp. 2767-2787. ISSN 1078-0998 (2016) [Refereed Article] DOI: 10.1097/MIB.0000000000000970 [eCite] [Details] Citations: Scopus - 22Web of Science - 21 Tweet
2015	Ashworth Briggs EL, Toh TY, Eri RD, Hewitt A, Cook AL, 'TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients', Molecular Vision, 21 pp. 1162-1172. ISSN 1090-0535 (2015) [Refereed Article] PMID: 26539028 [eCite] [Details] Citations: Web of Science - 23 Co-authors: Ashworth Briggs EL; Hewitt A; Cook AL Tweet
2015	Cheluvappa R, Eri R, 'Conjugate products of pyocyanin-glutathione reactions', Chemico-Biological Interactions: a journal of molecular, cellular and biochemical toxicology, 238 pp. 91-92. ISSN 0009-2797 (2015) [Letter or Note in Journal] DOI: 10.1016/j.cbi.2015.06.002 [eCite] [Details] Citations: Scopus - 1 Tweet
2015	Cheluvappa R, Eri R, Luo AS, Grimm MC, 'Modulation of interferon activity-associated soluble molecules by appendicitis and appendectomy limits colitis-identification of novel anti-colitic targets', Journal of Interferon and Cytokine Research, 35, (2) pp. 108-115. ISSN 1079-9907 (2015) [Refereed Article] DOI: 10.1089/jir.2014.0091 [eCite] [Details] Citations: Scopus - 8Web of Science - 8 Tweet
2015	Eapen MS, Shukla SD, Mahmood MQ, McAlinden-Volkovickas KD, Eri RD, et al., 'Current understanding of corticosteroid therapy in chronic obstructive pulmonary disease (COPD): an overview', International Journal of Medical and Biological Frontiers, 21, (1) ISSN 1081-3829 (2015) [Non Refereed Article] [eCite] [Details] Co-authors: Eapen MS; Shukla SD; Mahmood MQ; McAlinden-Volkovickas KD; Walters EH; Sohal SS
2015	Fox MJ, Ahuja KDK, Robertson IK, Ball MJ, Eri RD, 'Can probiotic yogurt prevent diarrhoea in children on antibiotics? A double-blind, randomised, placebo-controlled study', BMJ, 5, (1) Article e006474. ISSN 1756-1833 (2015) [Refereed Article] DOI: 10.1136/bmjopen-2014-006474 [eCite] [Details] Citations: Scopus - 44Web of Science - 43 Co-authors: Fox MJ; Ahuja KDK; Robertson IK; Ball MJ Tweet
2015	Lean QY, Eri RD, Fitton JH, Patel RP, Gueven N, 'Fucoidan extracts ameliorate acute colitis', PLoS One, 10, (6) Article e0128453. ISSN 1932-6203 (2015) [Refereed Article] DOI: 10.1371/journal.pone.0128453 [eCite] [Details] Citations: Scopus - 45Web of Science - 38 Co-authors: Lean QY; Patel RP; Gueven N Tweet
2015	Lean QY, Eri RD, Randall-Demllo S, Sohal SS, Stewart N, et al., 'Orally Administered Enoxaparin Ameliorates Acute Colitis by Reducing Macrophage-Associated Inflammatory Responses', PLoS One, 10, (7) Article e0134259. ISSN 1932-6203 (2015) [Refereed Article] DOI: 10.1371/journal.pone.0134259 [eCite] [Details] Citations: Scopus - 15Web of Science - 13 Co-authors: Lean QY; Randall-Demllo S; Sohal SS; Stewart N; Peterson GM; Guven N; Patel RP Tweet
2015	Lean QY, Gueven N, Eri RD, Bhatia R, Sohal SS, et al., 'Heparins in ulcerative colitis: proposed and potential reasons for inconsistent clinical outcomes', Expert Review of Clinical Pharmacology, 8, (6) pp. 795-811. ISSN 1751-2433 (2015) [Refereed Article] DOI: 10.1586/17512433.2015.1082425 [eCite] [Details] Citations: Scopus - 9Web of Science - 8 Co-authors: Lean QY; Gueven N; Sohal SS; Stewart N; Peterson GM; Patel RP Tweet
2015	Rahman AA, Robinson AM, Jovanovska V, Eri RD, Nurgali K, 'Alterations in the distal colon innervation in Winnie mouse model of spontaneous chronic colitis', Cell and Tissue Research, 362, (3) pp. 497-512. ISSN 0302-766X (2015) [Refereed Article] DOI: 10.1007/s00441-015-2251-3 [eCite] [Details] Citations: Scopus - 19Web of Science - 18 Tweet
2015	Wang R, Hasnain SZ, Tong H, Das I, Che-Hao Chen A, et al., 'Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model', Inflammatory Bowel Diseases, 21, (5) pp. 973-84. ISSN 1078-0998 (2015) [Refereed Article] DOI: 10.1097/MIB.0000000000000353 [eCite] [Details] Citations: Scopus - 19Web of Science - 18 Tweet
2014	Alkadhi S, Kunde D, Cheluvappa R, Randall-Demllo S, Eri R, 'The murine appendiceal microbiome is altered in spontaneous colitis and its pathological progression', Gut pathogens, 6 Article 25. ISSN 1757-4749 (2014) [Refereed Article] DOI: 10.1186/1757-4749-6-25 [eCite] [Details] Citations: Scopus - 23Web of Science - 22 Co-authors: Kunde D; Randall-Demllo S Tweet
2014	Cheluvappa R, Eri R, Luo AS, Grimm MC, 'Endothelin and vascular remodelling in colitis pathogenesis - Appendicitis and appendectomy limit colitis by suppressing endothelin pathways', International Journal of Colorectal Disease, 29, (11) pp. 1321-1328. ISSN 0179-1958 (2014) [Refereed Article] DOI: 10.1007/s00384-014-1974-z [eCite] [Details] Citations: Scopus - 8Web of Science - 6 Tweet
2014	Eri R, 'Peer observation of teaching: reflections of an early career academic', Universal Journal of Educational Research, 2, (9) pp. 625-631. ISSN 2332-3205 (2014) [Refereed Article] [eCite] [Details] Tweet
2014	Eri R, Cook A, Brown N, 'Reflections on the value of mapping the final theory examination in a molecular biochemistry unit', Journal of Microbiology and Biology Education, 15, (1) pp. 53-54. ISSN 1935-7885 (2014) [Refereed Article] DOI: 10.1128/jmbe.v15i1.679 [eCite] [Details] Co-authors: Cook A; Brown N Tweet
2013	Das I, Png CW, Oancea I, Hasnain SZ, Lourie R, et al., 'Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins', The Journal of Experimental Medicine, 210, (6) pp. 1201-1216. ISSN 0022-1007 (2013) [Refereed Article] DOI: 10.1084/jem.20121268 [eCite] [Details] Citations: Scopus - 57Web of Science - 57 Tweet
2013	Oancea I, Png CW, Das I, Lourie R, Winkler I, et al., 'A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity', Gut: An International Journal of Gastroenterology and Hepatology, 62, (4) pp. 594-605. ISSN 0017-5749 (2013) [Refereed Article] DOI: 10.1136/gutjnl-2012-302274 [eCite] [Details] Citations: Scopus - 38Web of Science - 39 Tweet
2013	Shabala L, Walker EJ, Eklund A, Randall-Demllo S, Shabala S, et al., 'Exposure of colonic epithelial cells to oxidative and endoplasmic reticulum stress causes rapid potassium efflux and calcium influx', Cell Biochemistry and Function, 31, (7) pp. 603-611. ISSN 1099-0844 (2013) [Refereed Article] DOI: 10.1002/cbf.2946 [eCite] [Details] Citations: Scopus - 7Web of Science - 7 Co-authors: Shabala L; Walker EJ; Randall-Demllo S; Shabala S; Guven N; Cook AL Tweet
2011	Eri RD, Adams RJ, Tran TV, Tong H, Das I, et al., 'An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity', Mucosal Immunology, 4, (3) pp. 354-364. ISSN 1933-0219 (2011) [Refereed Article] DOI: 10.1038/mi.2010.74 [eCite] [Details] Citations: Scopus - 86Web of Science - 77 Tweet
2011	McGuckin MA, Eri RD, Das I, Lourie R, Florin TH, 'Intestinal secretory cell ER stress and inflammation', Biochemical Society Transactions, 39, (4) pp. 1081-1085. ISSN 0300-5127 (2011) [Refereed Article] DOI: 10.1042/BST0391081 [eCite] [Details] Citations: Scopus - 35Web of Science - 32 Tweet
2010	McGuckin MA, Eri RD, Das I, Lourie R, Florin TH, 'ER stress and the unfolded protein response in intestinal inflammation', American Journal of Physiology: Gastrointestinal and Liver Physiology , 298, (6) pp. G820-G832. ISSN 0193-1857 (2010) [Refereed Article] DOI: 10.1152/ajpgi.00063.2010 [eCite] [Details] Citations: Scopus - 122Web of Science - 118 Tweet
2009	McGuckin MA, Eri RD, Simms LA, Florin TH, Radford-Smith G, 'Intestinal barrier dysfunction in inflammatory bowel diseases', Inflamm. Bowel Dis, 15, (1) pp. 100-113. ISSN 1536-4844 (2009) [Refereed Article] DOI: 10.1002/ibd.20539 [eCite] [Details] Citations: Scopus - 393Web of Science - 372 Tweet
2008	Eri RD, Heazlewood CK, Cook MC, Price GR, Tauro SB, et al., 'Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis', PLoS Med, 5, (3) pp. E54. ISSN 1549-1676 (2008) [Refereed Article] DOI: 10.1371/journal.pmed.0050054 [eCite] [Details] Citations: Scopus - 464Web of Science - 445 Tweet
2008	Eri RD, Kodumudi N, Summerlin D, Srinivasan M, 'Suppression of colon inflammation by CD80 blockade: Evaluation in two murine models of inflammatory bowel disease', Inflammatory Bowel Disease, 14, (4) pp. 458-470. ISSN 1536-4844 (2008) [Refereed Article] DOI: 10.1002/ibd.20344 [eCite] [Details] Citations: Scopus - 22Web of Science - 21 Tweet
2008	O'Malley JT, Eri RD, Stritesky GL, Mathur AN, Chang HC, et al., 'STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease', Journal of Immunology, 181, (7) pp. 5062-5070. ISSN 0022-1767 (2008) [Refereed Article] DOI: 10.4049/jimmunol.181.7.5062 [eCite] [Details] Citations: Scopus - 27Web of Science - 27 Tweet
2007	Srinivasan M, Eri RD, Zunt SL, Summerlin DJ, Brand DD, et al., 'Suppression of immune responses in collagen-induced arthritis by a rationally designed CD80-binding peptide agent', Arthritis & Rheumatism, 56, (2) pp. 498-508. ISSN 1529-0131 (2007) [Refereed Article] DOI: 10.1002/art.22324 [eCite] [Details] Citations: Scopus - 13Web of Science - 12 Tweet
2006	Hume GE, Fowler EV, Lincoln D, Eri RD, Templeton D, et al., 'Angiotensinogen and transforming growth factor beta1: novel genes in the pathogenesis of Crohn's disease', Journal of Medical Genetics, 43, (10) pp. e51. ISSN 1468-6244 (2006) [Refereed Article] DOI: 10.1136/jmg.2005.040477 [eCite] [Details] Citations: Scopus - 24Web of Science - 19 Tweet
2006	Michael-Robinson JM, Pandeya N, Walsh MD, Biemer-Huttmann AE, Eri RD, et al., 'Characterization of tumour-infiltrating lymphocytes and apoptosis in colitis-associated neoplasia: comparison with sporadic colorectal cancer', The Journal of Pathology, 208, (3) pp. 381-387. ISSN 1096-9896 (2006) [Refereed Article] DOI: 10.1002/path.1895 [eCite] [Details] Citations: Scopus - 14Web of Science - 12 Tweet
2005	Fowler EV, Eri RD, Hume G, Johnstone S, Pandeya N, et al., 'GLTNFalpha and IL10 SNPs act together to predict disease behaviour in Crohn's disease', Journal of Medical Genetics, 42, (6) pp. 523-528. ISSN 1468-6244 (2005) [Refereed Article] DOI: 10.1136/jmg.2004.027425 [eCite] [Details] Citations: Scopus - 52Web of Science - 47 Tweet
2005	Fukata M, Michelsen KS, Eri RD, Thomas LS, Hu B, et al., 'Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis', American Journal of Physiology: Gastrointestinal and Liver Physiology, 288, (5) pp. 1055-1065. ISSN 0193-1857 (2005) [Refereed Article] DOI: 10.1152/ajpgi.00328.2004 [eCite] [Details] Citations: Scopus - 401Web of Science - 368 Tweet
2005	Srinivasan M, Lu D, Eri RD, Brand DD, Haque A, et al., 'CD80 binding polyproline helical peptide inhibits T cell activation', Journal of Biological Chemistry, 280, (11) pp. 10149-10155. ISSN 0021-9258 (2005) [Refereed Article] DOI: 10.1074/jbc.M409521200 [eCite] [Details] Citations: Scopus - 19Web of Science - 18 Tweet
2004	Eri RD, Jonsson JR, Pandeya N, Purdie DM, Clouston AD, et al., 'CCR5-Delta32 mutation is strongly associated with primary sclerosing cholangitis', Genes and Immunity, 6, (6) pp. 444-450. ISSN 1466-4879 (2004) [Refereed Article] DOI: 10.1038/sj.gene.6364113 [eCite] [Details] Citations: Web of Science - 42 Tweet
1999	Eri RD, Arnold J, Hinman V, Green K, Jones M, et al., 'Hemps, a novel EGF-like protein plays a central role in ascidian metamorphosis', Development (Cambridge), 126, (24) pp. 5809-5818 . ISSN 0950-1991 (1999) [Refereed Article] [eCite] [Details] Citations: Web of Science - 57
1997	Arnold J, Eri RD, Degnan B, Lavin MF, 'Novel gene containing multiple epidermal growth factor-like motifs transiently expressed in the papillae of the ascidian tadpole larvae', Developmental Dynamics, 210, (3) pp. 264-273. ISSN 1058-8388 (1997) [Refereed Article] DOI: 10.1002/(SICI)1097-0177(199711)210:3<264::AID-AJA7>3.3.CO;2-D [eCite] [Details] Citations: Web of Science - 17 Tweet

Chapter in Book

(3 outputs)

Year	Citation	Altmetrics
2016	Lean QY, Gueven N, Eri RD, Peterson GM, Patel RP, 'Non-Anticoagulant Oligosaccharides of Enoxaparin Relieve Chemical-Induced Acute Colitis', Advances in Medicine and Biology, Nova Science Publishers, LV Berhardt (ed), United States, pp. 87-104. ISBN 978-1-63483-988-4 (2016) [Research Book Chapter] [eCite] [Details] Co-authors: Lean QY; Gueven N; Peterson GM; Patel RP Tweet
2015	Eapen MS, Shukla SD, Mahmood MQ, McAlinden-Volkovickas KD, Eri RD, et al., 'Role of corticosteroids in chronic obstructive pulmonary disease (COPD)', Corticosteroids and Steroid Therapy: New Research, Nova Science Publishers, C Adkins (ed), United Kingdom, pp. 1-40. ISBN 978-1634823081 (2015) [Research Book Chapter] [eCite] [Details] Co-authors: Eapen MS; Shukla SD; Mahmood MQ; McAlinden-Volkovickas KD; Walters EH; Sohal SS Tweet
2012	Eri RD, McGuckin MA, Wadley R, 'T cell transfer model of colitis: a great tool to assess the contribution of T cells in chronic intestinal inflammation', Leucocytes: Methods and Protocols, Methods in Molecular Biology, Humana Press, Robert B. Ashman (ed), United States, pp. 261-275. ISBN 978-1-61779-526-8 (2012) [Research Book Chapter] DOI: 10.1007/978-1-61779-527-5_19 [eCite] [Details] Citations: Scopus - 31 Tweet

Year

Citation

Altmetrics

2016

Lean QY, Gueven N, Eri RD, Peterson GM, Patel RP, 'Non-Anticoagulant Oligosaccharides of Enoxaparin Relieve Chemical-Induced Acute Colitis', Advances in Medicine and Biology, Nova Science Publishers, LV Berhardt (ed), United States, pp. 87-104. ISBN 978-1-63483-988-4 (2016) [Research Book Chapter]

[eCite] [Details]

Co-authors: Lean QY; Gueven N; Peterson GM; Patel RP

2015

Eapen MS, Shukla SD, Mahmood MQ, McAlinden-Volkovickas KD, Eri RD, et al., 'Role of corticosteroids in chronic obstructive pulmonary disease (COPD)', Corticosteroids and Steroid Therapy: New Research, Nova Science Publishers, C Adkins (ed), United Kingdom, pp. 1-40. ISBN 978-1634823081 (2015) [Research Book Chapter]

[eCite] [Details]

Co-authors: Eapen MS; Shukla SD; Mahmood MQ; McAlinden-Volkovickas KD; Walters EH; Sohal SS

2012

Eri RD, McGuckin MA, Wadley R, 'T cell transfer model of colitis: a great tool to assess the contribution of T cells in chronic intestinal inflammation', Leucocytes: Methods and Protocols, Methods in Molecular Biology, Humana Press, Robert B. Ashman (ed), United States, pp. 261-275. ISBN 978-1-61779-526-8 (2012) [Research Book Chapter]

DOI: 10.1007/978-1-61779-527-5_19 [eCite] [Details]

Citations: Scopus - 31

Review

(12 outputs)

Year	Citation	Altmetrics
2019	Ranasinghe R, Eri R, 'CCR6-CCL20-Mediated Immunologic Pathways in Inflammatory Bowel Disease', Gastrointestinal Disorders, 1, (1) pp. 15-29. ISSN 2624-5647 (2019) [Review Several Works] DOI: 10.3390/gidisord1010003 [eCite] [Details] Tweet
2019	Ranasinghe R, Eri R, 'CCR6-CCL20 Axis in IBD: What Have We Learnt in the Last 20 Years?', Gastrointestinal Disorders, 1 pp. 57-74. ISSN 2624-5647 (2019) [Review Several Works] DOI: 10.3390/gidisord1010006 [eCite] [Details] Tweet
2018	Ranasinghe R, Eri R, 'Modulation of the CCR6-CCL20 Axis: A Potential Therapeutic Target in Inflammation and Cancer', Medicina, 54, (5) pp. 1-12. ISSN 1010-660X (2018) [Review Several Works] DOI: 10.3390/medicina54050088 [eCite] [Details] Citations: Scopus - 13Web of Science - 11 Tweet
2018	Ranson N, Kunde D, Eri R, 'Regulation and sensing of inflammasomes and their impact on intestinal health', International Journal of Molecular Sciences, 18, (11) pp. 1-19. ISSN 1661-6596 (2018) [Substantial Review] DOI: 10.3390/ijms18112379 [eCite] [Details] Citations: Scopus - 14Web of Science - 14 Co-authors: Ranson N; Kunde D Tweet
2017	Chong WC, Shastri MD, Eri R, 'Endoplasmic reticulum stress and oxidative stress: A vicious nexus implicated in bowel disease pathophysiology', International Journal of Molecular Sciences, 18 (4) Article 771. ISSN 1661-6596 (2017) [Substantial Review] DOI: 10.3390/ijms18040771 [eCite] [Details] Citations: Scopus - 96Web of Science - 90 Co-authors: Chong WC; Shastri MD Tweet
2017	Vemuri R, Gundamaraju R, Eri R, 'Role of lactic acid probiotic bacteria in IBD', Current Pharmaceutical Design, 23, (16) pp. 2352-2355. ISSN 1381-6128 (2017) [Review Several Works] DOI: 10.2174/1381612823666170207100025 [eCite] [Details] Citations: Scopus - 14Web of Science - 13 Co-authors: Vemuri R Tweet
2013	Basheer W, Kunde DA, Eri RD, 'Role of Chemokine Ligand CCL20 and its Receptor CCR6 in lntestinal Inflammation', Immunology and Infectious Diseases, 1, (2) pp. 30-37. ISSN 2333-2719 (2013) [Substantial Review] DOI: 10.13189/iid.2013.010203 [eCite] [Details] Co-authors: Basheer W; Kunde DA Tweet
2013	Eri RD, Chieppa M, 'Messages from the inside. The dynamic environment that favors intestinal homeostasis', Frontiers in Immunology, 4 pp. 1-7. ISSN 1664-3224 (2013) [Substantial Review] DOI: 10.3389/fimmu.2013.00323 [eCite] [Details] Citations: Scopus - 16Web of Science - 15 Tweet
2013	Fox M, Ahuja KDK, Eri RD, 'Efficacy of probiotics in the prevention of antibiotic-associated diarrhoea (AAD) in children - a review', International Journal of Probiotics and Prebiotics, 8, (2/3) pp. 61-66. ISSN 1555-1431 (2013) [Substantial Review] [eCite] [Details] Co-authors: Fox M; Ahuja KDK
2013	Lee AYS, Eri RD, Lyons AB, Grimm MC, Korner H, 'CC chemokine ligand 20 and its cognate receptor CCR6 in mucosal T cell immunology and inflammatory bowel disease: odd couple or axis of evil?', Frontiers in Immunology, 4, (194) pp. 1-7. ISSN 1664-3224 (2013) [Substantial Review] DOI: 10.3389/fimmu.2013.00194 [eCite] [Details] Citations: Scopus - 55Web of Science - 56 Co-authors: Lee AYS; Lyons AB; Korner H Tweet
2013	Randall-Demllo S, Chieppa M, Eri RD, 'Intestinal epithelium and autophagy: partners in gut homeostasis', Frontiers in Immunology, 4 pp. 1-14. ISSN 1664-3224 (2013) [Substantial Review] DOI: 10.3389/fimmu.2013.00301 [eCite] [Details] Citations: Scopus - 62Web of Science - 66 Co-authors: Randall-Demllo S Tweet
2013	Ranson NM, Eri RD, 'The Role of Inflammasomes in Intestinal Inflammation', American Journal of Medical and Biological Research, 1, (3) pp. 64-76. ISSN 2328-4080 (2013) [Substantial Review] DOI: 10.12691/ajmbr-1-3-3 [eCite] [Details] Co-authors: Ranson NM Tweet

Conference Publication

(3 outputs)

Year	Citation	Altmetrics
2017	Shinde T, Tristram SG, Stanley RA, Eri RD, 'Survival, adhesion and immunomodulatory efficacy of spore-forming probiotic Bacillus coagulans', Australian Society for Microbiology National Scientific Meeting, Hobart 2017, 2-5 July, Hobart, Tasmania (2017) [Conference Extract] [eCite] [Details] Co-authors: Tristram SG; Stanley RA
2014	Cook AL, Ashworth Briggs EL, Toh T, Eri RD, Hewitt A, 'Defining conditions to direct human pluripotent stem cells towards the glaucoma-affected trabecular meshwork cell lineage', 2014 Australian Health and Medical Research Congress (AHMRC), 16-19 November, 2014, Melbourne, Australia (2014) [Conference Extract] [eCite] [Details] Co-authors: Cook AL; Ashworth Briggs EL; Hewitt A
2014	Fox MJ, Ahuja KDK, Robertson IK, Ball MJ, Eri RD, 'Probiotic yoghurt and incidence of diarrhoea in children: a double blind, randomised, controlled trial', Thirty-Eighth Annual Scientific Meeting of The Nutrition Society of Australia, 26 - 28 November, 2014, Hobart, Tasmania (2014) [Conference Extract] [eCite] [Details] Co-authors: Fox MJ; Ahuja KDK; Robertson IK; Ball MJ

Year

Citation

Altmetrics

2017

Shinde T, Tristram SG, Stanley RA, Eri RD, 'Survival, adhesion and immunomodulatory efficacy of spore-forming probiotic Bacillus coagulans', Australian Society for Microbiology National Scientific Meeting, Hobart 2017, 2-5 July, Hobart, Tasmania (2017) [Conference Extract]

[eCite] [Details]

Co-authors: Tristram SG; Stanley RA

2014

Cook AL, Ashworth Briggs EL, Toh T, Eri RD, Hewitt A, 'Defining conditions to direct human pluripotent stem cells towards the glaucoma-affected trabecular meshwork cell lineage', 2014 Australian Health and Medical Research Congress (AHMRC), 16-19 November, 2014, Melbourne, Australia (2014) [Conference Extract]

[eCite] [Details]

Co-authors: Cook AL; Ashworth Briggs EL; Hewitt A

2014

Fox MJ, Ahuja KDK, Robertson IK, Ball MJ, Eri RD, 'Probiotic yoghurt and incidence of diarrhoea in children: a double blind, randomised, controlled trial', Thirty-Eighth Annual Scientific Meeting of The Nutrition Society of Australia, 26 - 28 November, 2014, Hobart, Tasmania (2014) [Conference Extract]

[eCite] [Details]

Co-authors: Fox MJ; Ahuja KDK; Robertson IK; Ball MJ

Major Creative Work

(1 outputs)

Year	Citation	Altmetrics
2016	Bywaters MC, Lehman K, Eri R, Huang T, Fan F, 'Navigating the internal landscape: an artistic interpretation of disease', University of Tasmania, Academy Gallery - Launceston and Makers Space - Burnie, 500, pp. 8 (2016) [Other Exhibition] [eCite] [Details] Co-authors: Bywaters MC; Lehman K; Huang T

Year

Citation

Altmetrics

2016

Bywaters MC, Lehman K, Eri R, Huang T, Fan F, 'Navigating the internal landscape: an artistic interpretation of disease', University of Tasmania, Academy Gallery - Launceston and Makers Space - Burnie, 500, pp. 8 (2016) [Other Exhibition]

[eCite] [Details]

Co-authors: Bywaters MC; Lehman K; Huang T

Other Public Output

(1 outputs)

Year	Citation	Altmetrics
2014	Simpson H, Duers L, Rankin J, McFadyen J, Campbell SJ, et al., 'Health Benchmarking Project Final Report', University of Tasmania and University of the West of Scotland, pp. 1-45. (2014) [Government or Industry Research] [eCite] [Details] Co-authors: Campbell SJ; Stirling CM; Walsh K; Ford K; Geraghty DP; Williams AD; Robinson AL; Miller AB; Cross M; McKay AJ; Sondermeyer J; Elmer SL; Cooper JF; Booth S

Year

Citation

Altmetrics

2014

Simpson H, Duers L, Rankin J, McFadyen J, Campbell SJ, et al., 'Health Benchmarking Project Final Report', University of Tasmania and University of the West of Scotland, pp. 1-45. (2014) [Government or Industry Research]

[eCite] [Details]

Co-authors: Campbell SJ; Stirling CM; Walsh K; Ford K; Geraghty DP; Williams AD; Robinson AL; Miller AB; Cross M; McKay AJ; Sondermeyer J; Elmer SL; Cooper JF; Booth S

Grants & Funding

Funding Summary

Number of grants

Total funding

$1,469,823

Projects

Cognition in multiple sclerosis: Associations with gut-brain biomarkers and exploration of cognitive symptom change in response to a nutrition intervention (2021 - 2022)$57,683

Description: Cognitive dysfunction is common in people with Multiple Sclerosis (MS) and can cause significant disruption to everyday functioning and quality of life. Peculiarities in gut microbial composition and function have also been found in people with MS and there is now a recognised link between the gut microbiome and kynurenine pathway (KP) regulation, as well as KP dysregulation, increased inflammation and neuronal death. This research aims to examine whether cognitive dysfunction and cognitive changes over time (approximately a 4-year period, time 1 data was collected in 2016/2017) are associated with increased pro-inflammatory KP biomarkers and an aberrant gut microbiota among individuals with MS. We will also conduct a pilot study investigating whether and to what extent a nutrition intervention (e.g., probiotics) may influence cognitive impairment in MS, by modulating KP function via the gut microbiome.
Funding: Clifford Craig Foundation ($57,683)
Scheme: Grant
Administered By: University of Tasmania
Research Team: Honan CA; Eri RD; Giles L; Johnson OL; Marx W; Lim E
Period: 2021 - 2022

Basic understanding of Tasmanian older adult gut microbiota (2018)$7,000

Funding: Clifford Craig Foundation ($7,000)
Scheme: Grant
Administered By: Launceston General Hospital
Research Team: Eri RD; Flanagan Katie
Year: 2018

The Role of NLRP3 Inflammasome in Colitis-associated Colorectal Cancer (2018)$24,940

Description: Our lab has generated a novel mouse model of ulcerative colitis-induced colorectal cancer. We will investigate the molecular mechanisms involved in the transformation of colitis to colorectal cancer.
Funding: Cancer Council of Tasmania ($24,940)
Scheme: Grant-Small
Administered By: University of Tasmania
Research Team: Shastri M; Eri RD
Year: 2018

Vaccine Immunomodulation Throughout the Aging Lifespan (2017 - 2019)$54,437

Description: Vaccine trial involving older adults in Launceston. The projects investigates the immune responses to vaccination in the elderly.
Funding: Launceston General Hospital ($54,437)
Scheme: Contract Research
Administered By: University of Tasmania
Research Team: Eri RD; Flanagan Katie; Byrne N
Period: 2017 - 2019

Efficacy of K-Fibre in gastrointestinal health (2017 - 2018)$74,871

Description: Funding will be provided for two projects which utilise the KFSU product K-fibreTM. Project 1: Efficacy of K-fibre in ameliorating gut inflammation in animal model of colitis; Project 2: Efficacy of Kfibre in combating Gastroesophageal Reflux Disease Preliminary Human Clinical Study.
Funding: KFSU Ltd ($74,871)
Scheme: Contract Research
Administered By: University of Tasmania
Research Team: Eri RD; Stanley RA
Period: 2017 - 2018

Can blockade of inflammasomes be a therapeutic option in inflammatory bowel disease (IBD)?- A pilot study (2017)$34,687

Description: We propose to conduct functional study involving blockade of protein complexes called inflammasomes in inflammatory bowel disease. The project will utilise human tissue to understand therapeutic efficacy of inflammasome blocking.
Funding: Clifford Craig Foundation ($34,687)
Scheme: Grant
Administered By: University of Tasmania
Research Team: Eri RD; Kunde DA; Mitchell B; Fanning S
Year: 2017

Investigation of the role of NLRP3 in inflammatory Bowel Diseases (2017 - 2018)$22,727

Description: We propose to conduct functional study involving blockade of protein complexes called inflammasomes in inflammatory bowel disease. The project will utilise human tissue to understand therapeutic efficacy of inflammasome blocking.
Funding: Gastroenterological Society of Australia ($22,727)
Scheme: Award-Takeda IBD
Administered By: University of Tasmania
Research Team: Eri RD; Veldhuis M
Period: 2017 - 2018

Developing CRISPR/Cas Library Screens for identifying Novel Cancer Therapies (2017)$63,845

Description: Our understanding of many cancers has improved dramatically over the past decade predominantly due to our ability to sequence entire genomes, at scale. Yet, we still require a better understanding of the underlying mechanisms that initiate and perpetuate cancers, as well as gene-based factors that initiate the transition from indolent to aggressive cancers with a propensity to metastasize. CRISPR/Cas is proving a robust, powerful and necessary tool in the laboratory that will undoubtedly underpin the next breakthrough in the field of cancer. As such, it is essential that we develop this capability at the University of Tasmania in a timely manner.The specific AIMS of this proposal are to:Aim 1: Establish CRISPR/Cas screening at the University of Tasmania as a tool to identify genesthat drive aggressive and metastatic cancers.Aim 2: Perform a genome-wide CRISPR/Cas negative selection (loss-of-function) screen toidentify genes essential for proliferation and survival, as well as metastatic behaviour.
Funding: University of Tasmania Foundation Inc ($63,845)
Scheme: Grant-Cancer Research
Administered By: University of Tasmania
Research Team: Taberlay PC; Hewitt A; Holloway AF; Liu G; Dickinson JL; Brettingham-Moore KH; Fitzgerald L; Eri RD; Cook AL
Year: 2017

Anti-inflammatory efficacy of Marinovas Fucoidan & interactions with microbiota (2016)$100,000

Description: Industry interaction to develop Marinovas fucoidan extracts for gut health
Funding: Department of Industry, Innovation and Science ($50,000); Marinova Pty Ltd ($50,000)
Scheme: Contract Research
Administered By: University of Tasmania
Research Team: Guven N; Eri RD; Ahuja KDK; Ball MJ; Ambrose M; Roddam LF; Zosky GR
Year: 2016

Exploring the mechanisms responsible for the early transformation from chronic colitis to colorectal cancer (2016)$28,000

Description: This project will be the first study to model early changes in inflammation-associated colitis without the need for carcinogentreatment, which mirrors the clinical situation of human colitis. The project will study the histological and biochemical changes associated with the development of colorectal cancer in this mouse model that closely resembles the development seen in humans. The project will also investigate the mirobiome changes in the progression.
Funding: Cancer Council of Tasmania ($28,000)
Scheme: Grant-Cancer Research
Administered By: University of Tasmania
Research Team: Kunde DA; Eri RD; Holloway AF
Year: 2016

Epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): role in both airway fibrosis and lung cancer (2016)$39,206

Description: Small airway fibrosis is the main contributor to physiological airway obstruction in COPD. The other main airway pathology in COPD is lung cancer; up to 70% of smoking related lung cancer occurs in mild-moderate COPD. EMT may underlie both pathological features; if true this opens up major new therapeutic possibilities. We aim to investigate EMT in airways of smokers and COPD.
Funding: Clifford Craig Foundation ($39,206)
Scheme: Grant
Administered By: University of Tasmania
Research Team: Sohal SS; Chia Collin; Larby J; Haug G; Eri RD; Myers SA; Noor WD
Year: 2016

Fucoidan and stem cell mobilisation (2015)$27,048

Description: Industry interaction to test if Marinova's fucoidan extracts mobilise stem cells.
Funding: Marinova Pty Ltd ($27,048)
Scheme: Clinical Trial
Administered By: University of Tasmania
Research Team: Guven N; Eri RD; Ahuja KDK; Patel RP
Year: 2015

Making sense of biology data through artistic interactions (2015)$6,856

Description: This project draws on latest research results from the fields of visual arts, visualisation, health and education and aims to design and evaluate artistic interaction methods. It is hypothesised that by introducing artistic interactions, users will be more engaged with the sense-making process, thus making the visualisation more effective in conveying the embedded information to the end users, in comparison with traditional reality based interactions.
Funding: University of Tasmania ($6,856)
Scheme: Grant-Cross-Disciplinary Incentive
Administered By: University of Tasmania
Research Team: Bywaters MC; Huang W; Fan S; Lehman KF; Eri RD
Year: 2015

Fucoidan and gut health (2015)$100,000

Description: This project represents industry interaction to develop Marinovas fucoidan extract for gut health.
Funding: Department of Industry, Science, Energy and Resources ($50,000)
Scheme: Grant
Administered By: University of Tasmania
Research Team: Guven N; Davis E; Eri RD; Patel RP
Year: 2015

Non anticoagulant molecules of heparin for the management of ulcerative colitis (2015)$15,000

Description: This project aims to achieve the identification and evaluation of non-anticoagulant molecules of heparin that are responsible for the observed beneficial effects of heparin in patients with ulcerative colitis as well as to compare potential biomarkers in a preclinical muse model with ulcerative colitis patients.
Funding: Royal Hobart Hospital Research Foundation ($15,000)
Scheme: Grant-Clinical Research
Administered By: University of Tasmania
Research Team: Patel RP; Guven N; Eri RD; Bhatia R
Year: 2015

Investigation of carcinogenesis pathways in colitis-associated colorectal cancer (2014)$7,000

Funding: Department of Health and Human Services Tasmania ($7,000)
Scheme: Donation - Individual
Administered By: University of Tasmania
Research Team: Eri RD
Year: 2014

Extracellular matrix remodelling in the glaucomatous trabecular meshwork (2014)$36,235

Description: Glaucoma is a degenerative disease attributed to progressive loss of neurons within the optic nerve. There is no cure for this disease, with treatment strategies predominantly focused on reducing intraocular pressure (IOP), which remains the only modifiable risk factor. IOP is generally considered to be due to inhibited outflow of aqueous humor, the fluid within the eye, through a specialised tissue known as the trabecular meshwork. The trabecular meshwork (TM) is highly fibrous, consisting of several layers of cells overlying extracellular matrix (ECM) structures. During normal ageing, increased ECM deposition occurs in the deeper layers of the trabecular meshwork, and this appears to be increased in glaucoma. It is not known how this occurs, but it has been speculated that changes in expression and activity of ECM remodelling proteins, typified by matrix metalloproteinases (MMPs) and their regulators, tissue inhibitor of metalloproteinases (TIMPs), may be responsible. Several studies have examined gene expression and the ECM structure in normal and glaucomatous trabecular meshwork, as well as the presence of MMPs and TIMPS in aqueous humor, but no study has attempted to correlate the extent of ECM deposition with MMP or TIMP activity using trabecular meshwork tissue and aqueous humor from the same patient.
Funding: Clifford Craig Foundation ($36,235)
Scheme: Grant
Administered By: University of Tasmania
Research Team: Cook AL; Toh TY; Hewitt Alex; Eri RD
Year: 2014

Investigation of carcinogenesis pathways in colitis-associated colorectal cancer (2014)$24,409

Description: The aims of the project are: to study the expression levels of different inflammation molecules and inflammasome components in ulcerative colities patients, UC-associated-colorectal patients, sporadic colorectal patients compared to controls; to identify the cell populations where different inflammasome components are localised.
Funding: Clifford Craig Foundation ($24,409)
Scheme: Grant
Administered By: University of Tasmania
Research Team: Eri RD; Lloyd D; Mitchell B; Fanning S; Ahuja KDK; Cook AL
Year: 2014

The INK4 locus in glaucoma - functional assessment of the non-coding RNA gene ANRIL in patient-specific cells (2013)$27,273

Funding: Clifford Craig Foundation ($27,273)
Scheme: Grant
Administered By: University of Tasmania
Research Team: Cook AL; Eri RD; Hewitt Alex; Toh TY
Year: 2013

Understanding the role of inflammasomes in inflammatory bowel disease (IBD) (2013 - 2014)$54,546

Funding: Clifford Craig Foundation ($54,546)
Scheme: Grant
Administered By: University of Tasmania
Research Team: Eri RD; Cook AL; Mitchell B; Wilson Raymond
Period: 2013 - 2014

Investigation of carcinogenesis pathways in colitis-associated colorectal cancer (Scholarship Sarron Randall-Demllo) (2013 - 2015)$54,000

Funding: Australian Rotary Health Research Fund ($54,000)
Scheme: Scholarship-Funding Partners
Administered By: University of Tasmania
Research Team: Eri RD; Spring K; Cook AL
Period: 2013 - 2015

2013: The 16th International Congress of Mucosal Immunology (ICMI 2013) Canada 17 to 20 July 2013 (2013)$2,460

Funding: University of Tasmania ($2,460)
Scheme: Grant-Conference Support Scheme
Administered By: University of Tasmania
Research Team: Eri RD
Year: 2013

Glaucoma Fibroblast Cultures (2012)$10,000

Description: The project aims to establish and bank glaucoma patient-specific fibroblast cell lines and conduct molecular analyses on these cell lines.
Funding: Centre for Eye Research Aust Ltd ($10,000)
Scheme: Contract Research
Administered By: University of Tasmania
Research Team: Cook AL; Eri RD
Year: 2012

International Congress of Mucosal Immunology Conference - 5 to 9 July 2011, France (June 2011) (2011)$2,100

Funding: University of Tasmania ($2,100)
Scheme: Grant-Conference Support Scheme
Administered By: University of Tasmania
Research Team: Eri RD
Year: 2011

Exploring the Mechanisms of Generation of Intestinal TH17 Responses and the Mechanisms of TH17 mediated Pathology (2010 - 2012)$595,500

Funding: National Health & Medical Research Council ($595,500)
Scheme: Grant-Project
Administered By: Mater Medical Research Institute
Research Team: Eri RD; Cook M; McKenzie BS; McGuckin MA; Florin THJ
Period: 2010 - 2012
Grant Reference: 604304

Research Supervision

Current

Completed

Current

Degree	Title	Commenced
PhD	Targeting Wnt Signaling Pathway in the Treatment of Colorectal Cancer	2016
PhD	Fucoidan and its Effects on Inflammation	2017
PhD	Developing Asperuloside, a Newly Compund Important for Food Intake Reduction in Obesity	2018
PhD	Investigation of Early Predictors in Insulin Resistance and Type 2 Diabetes Mellitus	2018
PhD	Targeting Serotoninergic Systems for Modulation of Fear Associated Memories	2018
PhD	The Role of NLRP3 Inflammasome in Colitis-associated Colorectal Cancer	2019
PhD	The Relationship Between the Gut Microbiome, Pro-Inflammatory Biomarkers and Cognitive Dysfunction in Multiple Sclerosis	2019

Completed

Degree	Title	Completed
Masters	Multi-system Pathophysiology and Molecular Signalling in a Ccr6-Deficient Murine Model of Spontaneous Colitis Candidate: Hewausaramba Ranmali Ranasinghe	2020
PhD	Synbiotic Efficacy of Probiotic and Prebiotic Food Ingredients for Gut Health Candidate: Tanvi Sandesh Shinde	2019
PhD	Investigating the Inner World of Stressed Goblet Cell Candidate: Rohit Gundamaraju	2019
PhD	Role of NLRP3 in Colitis and Colitis Associated Colorectal Cancer Candidate: Agampodi Promoda Prasadini Perera	2019
PhD	Investigation on the Utilization of Beneficial Microbes in Modulating the Gut Microbiota and Metabolic Profiles in Ageing Candidate: Ravichandra Vemuri	2019
PhD	Aqueous Humour Protein Imbalances in Primary Open-angle Glaucoma and Their Effects on Trabecular Meshwork Cell Function Candidate: Esther Lara Ashworth Briggs	2018
PhD	Inflammasome Activity in the Inflammatory Bowel Diseases Candidate: Nicole Maree Ranson	2018
PhD	Genetic Ablation of CCR6 Confers Differential Exacerbation in a Spontaneous Colitis Model Candidate: Waheedha Fathima Basheer	2017
PhD	Investigation of Neoplastic Transition of the Colonic Epithelium in the Winnie Mouse Model of Chronic Colitis Candidate: Sarron Yael Randall-Demllo	2017
Masters	In vitro Invasive Ability of X and V Factor Dependent Haemophilus Species Across Different Cell Types Candidate: Neeraj Kumar Singh	2016