Profiles
Brad Sutherland
Brad Sutherland
Associate Professor
Room MS2, Level 4, 437a , Medical Sciences Precinct
+61 3 6226 7634 (phone)
Associate Professor Brad Sutherland is an NHMRC Boosting Dementia Fellow in the Discipline of Medical Sciences, Tasmanian School of Medicine in the College of Health and Medicine. His main research interests focus on the regulation of the microvascular system, how it is controlled at the cellular and molecular level, and how this becomes dysfunctional in diseases such as stroke and dementia. He also teaches Neuroscience and Physiology into a number of units as part of the BMedRes degree.
Biography
Brad completed his PhD at the University of Otago (Dunedin, New Zealand) where he investigated the activation of inflammatory pathways in the brain after stroke. After a small stint as a Teaching Fellow in Pharmacology & Toxicology (University of Otago), he took up a Post-doctoral Research Fellowship with the Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford (Oxford, UK). During his time in Oxford, he formed an interest in the regulation of blood flow in the brain in health and disease. This led to studies investigating the interaction between brain tissue and the blood vessels, the signalling mechanisms that controlled energy delivery to the brain, and how these were disrupted in conditions such as stroke.
In mid-2016, Brad arrived at the University of Tasmania to continue his research into cerebral blood flow and brain diseases such as stroke and dementia. He continues to use a wide range of in vitro and in vivo models to assess mechanisms of neurovascular regulation and models of disease.
Career summary
Qualifications
Degree | Thesis title | University | Country | Date |
|---|---|---|---|---|
PhD | Heme oxygenase and the use of tin protoporphyrin in hypoxia-ischaemia-induced brain damage: mechanisms of action | University of Otago | New Zealand | 2009 |
BSc (1st Class Hons) | The neuroprotective effect of epigallocatechin gallate following hypoxia-ischaemia-induced brain damage and its mechanisms of action | University of Otago | New Zealand | 2004 |
Memberships
Professional practice
- The International Society for Cerebral Blood Flow and Metabolism (ISCBFM)
- Australasian Neuroscience Society (ANS)
- Australian Society for Medical Research (ASMR)
- NHMRC National Institute for Dementia Research (NNIDR)
Teaching
Pharmacology, Neuroscience, Neurological diseases, Biochemistry, Physiology, Neuropathology
Teaching expertise
Brad’s expertise is in the teaching of undergraduate Pharmacology, Neuroscience and Physiology. He also has experience in teaching Biochemistry and Neuropathology and coordinating Pharmacology units. He has also supervised both undergraduate and postgraduate research projects.
Teaching responsibility
Brad regularly contributes to the teaching of:
- Pharmacology (CSA230, CSA232, CSA234)
- Pharmacology (CSA231, CSA233, CSA235)
- Neuroscience A (CHP311)
- Neuroscience B (CHP312)
- Applied Physiology (CHP330)
- Research Project in Health and Disease (CBA344)
View more on AssocProf Brad Sutherland in WARP
Expertise
Over many years, Brad has developed skills in a range of techniques to investigate blood flow in the brain, and to perform in vitro and in vivo experiments. Specifically, he has experience with multiple stroke models including intraluminal filament middle cerebral artery occlusion (MCAO) model and hypoxia-ischaemia model. He also uses in vitro models of stroke on primary cells or cell lines in culture by exposing cells to oxygen and glucose deprivation. He uses a number of transgenic mouse lines to answer biological questions and employs a range of techniques including light, epifluorescence, confocal and two-photon microscopy, immunohistochemistry, histology, molecular biology, and animal behaviour. He also has experience with animal MRI. These techniques can be utilised to investigate the biological basis of a range of neurological disorders.
Research Themes
Brad’s research aligns to the University’s research theme of Better Health. His research interests include understanding how blood flow is regulated in the brain, identifying how vascular dysfunction can lead to multiple brain diseases such as stroke, dementia and other neurodegenerative diseases. He also focuses on the discovery of novel therapeutic targets that can prevent vascular dysfunction to stop disease progression in the brain. He utilises a wide range of in vitro and in vivo models to assess brain function and brain disease.
Blood flow in the brain is controlled by the neurovascular unit, which is a complex interplay of cells that communicate in order to increase blood - and therefore energy – supply in areas where brain activity is occurring. This is a tightly coupled process that uses complex paracrine signalling mechanisms and is prone to injury in disease. Brad is currently investigating the role of multiple cell types in the neurovascular unit and the mechanisms by which neurovascular dysfunction can occur.
Recently, Brad has developed an interest in the microcirculation, specifically a cell type called pericytes which exclusively reside on capillaries. These cells are involved in many brain processes including regulating blood flow in the brain and maintenance of the blood-brain barrier and may contribute to injury and repair of a number of diseases. Brad’s ongoing studies are examining mechanisms of pericyte dysfunction following stroke and dementia.
Collaboration
Brad is actively involved in a number of collaborations. Locally, Brad works closely with Prof David Howells, Dr Dino Premilovac and Prof Lisa Foa within the School of Medicine, A/Prof Kaylene Young in the Menzies and A/Prof Anna King and A/Prof Alison Canty in the Wicking. At a national level, Brad is a fellow of the NHMRC National Institute for Dementia Research which networks across the leading researchers in Dementia across Australia. He is also a member of StrokeCore which is a consortium of pre-clinical stroke researchers within Australia. Internationally, Brad continues to collaborate with Prof Alastair Buchan, A/Prof James Kennedy, A/Prof Nicola Sibson, A/Prof Gabriele De Luca and Dr Karl Morten from the University of Oxford (UK) on a range of stroke, Alzheimer’s disease and metabolism-related projects. He has also collaborated on blood flow-related projects with Prof David Attwell (University College London, UK), Prof Brian MacVicar (University of British Columbia, Canada), Prof Martin Lauritzen (University of Copenhagen, Denmark), Dr Clare Howarth (University of Sheffield, UK), Dr Chris Martin (University of Sheffield, UK) and Dr Catherine Hall (University of Sussex, UK).
Fields of Research
- Central nervous system (320903)
- Systems physiology (320803)
- Cellular nervous system (320902)
- Cardiology (incl. cardiovascular diseases) (320101)
- Basic pharmacology (321401)
- Signal transduction (310111)
- Neurology and neuromuscular diseases (320905)
- Cellular interactions (incl. adhesion, matrix, cell wall) (310105)
- Sensory systems (320907)
- Cell physiology (320801)
- Foetal development and medicine (321501)
- Cell neurochemistry (310104)
- Respiratory diseases (320103)
- Autonomic nervous system (320901)
- Nanomedicine (320604)
- Obstetrics and gynaecology (321502)
- Animal physiology - cell (310909)
- Ophthalmology (321201)
- Exercise physiology (420702)
- Cell development, proliferation and death (310102)
- Gene expression (incl. microarray and other genome-wide approaches) (310505)
- Neurosciences (320999)
- Cancer cell biology (321101)
- Animal physiology - systems (310910)
Research Objectives
- Clinical health (200199)
- Expanding knowledge in the health sciences (280112)
- Expanding knowledge in the biological sciences (280102)
- Neonatal and child health (200506)
- Expanding knowledge in the biomedical and clinical sciences (280103)
- Treatment of human diseases and conditions (200105)
Publications
Dr Sutherland publishes regularly in high impact journals. He has more than 35 peer-reviewed papers including papers in Nature, Brain and Journal of Cerebral Blood Flow and Metabolism. He reviews grant applications for a number of granting bodies as well papers for a wide range of neuroscience journals.
Total publications
51
Journal Article
(45 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2021 | Foster CG, Landowski LM, Sutherland BA, Howells DW, 'Differences in fatigue-like behavior in the lipopolysaccharide and poly I:C inflammatory animal models', Physiology and Behavior, 232 pp. 1-10. ISSN 0031-9384 (2021) [Refereed Article] DOI: 10.1016/j.physbeh.2021.113347 [eCite] [Details] Co-authors: Foster CG; Landowski LM; Howells DW | |
| 2020 | Beard DJ, Brown L, Sutherland BA, 'The rise of pericytes in neurovascular research', Journal of Cerebral Blood Flow & Metabolism Article Epub ahead of print. ISSN 0271-678X (2020) [Refereed Article] DOI: 10.1177/0271678X20958497 [eCite] [Details] Citations: Scopus - 1Web of Science - 1 Co-authors: Brown L | |
| 2020 | Courtney JM, Sutherland BA, 'Harnessing the stem cell properties of pericytes to repair the brain', Neural regeneration research, 15, (6) pp. 1021-1022. ISSN 1673-5374 (2020) [Refereed Article] DOI: 10.4103/1673-5374.270301 [eCite] [Details] Citations: Scopus - 2Web of Science - 1 Co-authors: Courtney JM | |
| 2020 | Foo LS, Larkin JR, Sutherland BA, Ray KJ, Yap W-S, et al., 'Study of common quantification methods of amide proton transfer magnetic resonance imaging for ischemic stroke detection', Magnetic Resonance in Medicine, 85, (4) pp. 2188-2200. ISSN 0740-3194 (2020) [Refereed Article] | |
| 2020 | Landowski LM, Niego B, Sutherland BA, Hagemeyer CE, Howells DW, 'Applications of Nanotechnology in the Diagnosis and Therapy of Stroke', Seminars in Thrombosis and Hemostasis, 46, (5) pp. 592-605. ISSN 0094-6176 (2020) [Refereed Article] DOI: 10.1055/s-0039-3399568 [eCite] [Details] Citations: Scopus - 4Web of Science - 3 Co-authors: Landowski LM; Howells DW | |
| 2020 | Premilovac D, Blackwood SJ, Ramsay C, Keske MA, Howells DW, et al., 'Transcranial contrast-enhanced ultrasound in the rat brain reveals substantial hyperperfusion acutely post-stroke', Journal of Cerebral Blood Flow and Metabolism pp. 1-15. ISSN 0271-678X (2020) [Refereed Article] DOI: 10.1177/0271678X20905493 [eCite] [Details] Co-authors: Premilovac D; Howells DW | |
| 2020 | Sutherland BA, Hadley G, Alexopoulou Z, Lodge TA, Neuhaus AA, et al., 'Growth differentiation factor-11 causes neurotoxicity during ischemia in vitro', Frontiers in Neurology pp. 1-8. ISSN 1664-2295 (2020) [Refereed Article] DOI: 10.3389/fneur.2020.01023 [eCite] [Details] Citations: Web of Science - 38 | |
| 2019 | Attrill E, Ramsay C, Ross R, Richards S, Sutherland BA, et al., 'Metabolic-vascular coupling in skeletal muscle: a potential role for capillary pericytes?', Clinical and Experimental Pharmacology and Physiology, 47, (3) pp. 520-528. ISSN 0305-1870 (2019) [Refereed Article] DOI: 10.1111/1440-1681.13208 [eCite] [Details] Citations: Scopus - 1Web of Science - 1 Co-authors: Ross R; Richards S; Premilovac D | |
| 2019 | Beard DJ, Hadley G, Thurley N, Howells DW, Sutherland BA, et al., 'The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies', International journal of stroke, 14, (2) pp. 137-145. ISSN 1747-4930 (2019) [Refereed Article] DOI: 10.1177/1747493018816503 [eCite] [Details] Citations: Scopus - 5Web of Science - 3 Co-authors: Howells DW | |
| 2019 | Brown LS, Foster CG, Courtney JM, King NE, Howells DW, et al., 'Pericytes and Neurovascular Function in the Healthy and Diseased Brain', Frontiers in cellular neuroscience pp. 1-9. ISSN 1662-5102 (2019) [Refereed Article] DOI: 10.3389/fncel.2019.00282 [eCite] [Details] Citations: Scopus - 42Web of Science - 40 Co-authors: Brown LS; Foster CG; Courtney JM; King NE; Howells DW | |
| 2019 | Hadley G, Beard DJ, Alexopoulou Z, Sutherland BA, Buchan AM, 'Investigation of the novel mTOR inhibitor AZD2014 in neuronal ischemia', Neuroscience Letters, 706 pp. 223-230. ISSN 0304-3940 (2019) [Refereed Article] DOI: 10.1016/j.neulet.2019.05.023 [eCite] [Details] Citations: Scopus - 2Web of Science - 2 | |
| 2019 | Hadley G, Beard DJ, Couch Y, Neuhaus AA, Adriaanse BA, et al., 'Rapamycin in ischemic stroke: old drug, new tricks?', Journal of Cerebral Blood Flow and Metabolism, 39, (1) pp. 20-35. ISSN 0271-678X (2019) [Refereed Article] DOI: 10.1177/0271678X18807309 [eCite] [Details] Citations: Scopus - 8Web of Science - 7 | |
| 2019 | Landowski LM, Niego B, Sutherland BA, Hagemeyer CE, Howells D, 'Applications of nanotechnology in the diagnosis and therapy of stroke', Seminars in Thrombosis and Hemostasis ISSN 0094-6176 (2019) [Refereed Article] DOI: 10.1055/s-0039-3399568 [eCite] [Details] Citations: Scopus - 4Web of Science - 3 Co-authors: Landowski LM; Howells D | |
| 2018 | Hadley G, Neuhaus AA, Couch Y, Beard DJ, Adriaanse BA, et al., 'The role of the endoplasmic reticulum stress response following cerebral ischemia', International journal of stroke, 13, (4) pp. 379-390. ISSN 1747-4930 (2018) [Refereed Article] DOI: 10.1177/1747493017724584 [eCite] [Details] Citations: Scopus - 10Web of Science - 10 | |
| 2017 | Howarth C, Sutherland BA, Choi HB, Martin C, Lind BL, et al., 'A critical role for astrocytes in hypercapnic vasodilation in brain', Journal of Neuroscience, 37, (9) pp. 2403-2414. ISSN 0270-6474 (2017) [Refereed Article] DOI: 10.1523/JNEUROSCI.0005-16.2016 [eCite] [Details] Citations: Scopus - 24Web of Science - 25 | |
| 2017 | Neuhaus AA, Couch Y, Sutherland BA, Buchan AM, 'Novel method to study pericyte contractility and responses to ischaemia in vitro using electrical impedance', Journal of Cerebral Blood Flow and Metabolism, 37, (6) pp. 2013-2024. ISSN 0271-678X (2017) [Refereed Article] DOI: 10.1177/0271678X16659495 [eCite] [Details] Citations: Scopus - 19Web of Science - 20 | |
| 2017 | Percie du Sert N, Alfieri A, Allan SM, Carswell HV, Deuchar GA, et al., 'The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)', Journal of Cerebral Blood Flow and Metabolism, 37, (11) pp. 3488-3517. ISSN 0271-678X (2017) [Refereed Article] DOI: 10.1177/0271678X17709185 [eCite] [Details] Citations: Scopus - 50Web of Science - 41 | |
| 2017 | Sutherland BA, Fordsmann JC, Martin C, Neuhaus AA, Witgen BM, et al., 'Multi-modal assessment of neurovascular coupling during cerebral ischaemia and reperfusion using remote middle cerebral artery occlusion', Journal of Cerebral Blood Flow and Metabolism, 37, (7) pp. 2494-2508. ISSN 1559-7016 (2017) [Refereed Article] DOI: 10.1177/0271678X16669512 [eCite] [Details] Citations: Scopus - 6Web of Science - 4 | |
| 2016 | Sutherland BA, Neuhaus AA, Couch Y, Balami JS, DeLuca GC, et al., 'The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke', Journal of cerebral blood flow and metabolism, 36, (2) pp. 363-369. ISSN 0271-678X (2016) [Refereed Article] DOI: 10.1177/0271678X15606722 [eCite] [Details] Citations: Scopus - 30Web of Science - 30 | |
| 2015 | Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM, 'Reply: Intravenous thrombolysis for ischaemic strokes: a call for reappraisal', Brain, 138, (4) pp. e342. ISSN 0006-8950 (2015) [Letter or Note in Journal] | |
| 2015 | Balami JS, Sutherland BA, Edmunds LD, Grunwald IQ, Neuhaus AA, et al., 'A systematic review and meta-analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke', International journal of stroke, 10, (8) pp. 1168-1178. ISSN 1747-4930 (2015) [Refereed Article] DOI: 10.1111/ijs.12618 [eCite] [Details] Citations: Scopus - 61Web of Science - 64 | |
| 2015 | Buchan AM, Karbalai HG, Sutherland BA, 'The future of stroke therapy must not be mired by past arguments', The Lancet, 386, (9994) pp. 654. ISSN 0140-6736 (2015) [Letter or Note in Journal] | |
| 2015 | Redzic ZB, Rabie T, Sutherland BA, Buchan AM, 'Differential effects of paracrine factors on the survival of cells of the neurovascular unit during oxygen glucose deprivation', International journal of stroke, 10, (3) pp. 407-414. ISSN 1747-4930 (2015) [Refereed Article] DOI: 10.1111/ijs.12197 [eCite] [Details] Citations: Scopus - 15Web of Science - 14 | |
| 2014 | Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM, 'Reply: Thrombolysis in acute ischaemic stroke', Brain, 137, (1) pp. e282. ISSN 0006-8950 (2014) [Letter or Note in Journal] | |
| 2014 | Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, et al., 'Capillary pericytes regulate cerebral blood flow in health and disease', Nature, 508, (7494) pp. 55-60. ISSN 0028-0836 (2014) [Refereed Article] DOI: 10.1038/nature13165 [eCite] [Details] Citations: Scopus - 763Web of Science - 755 | |
| 2014 | Neuhaus AA, Rabie T, Sutherland BA, Papadakis M, Hadley G, et al., 'Importance of preclinical research in the development of neuroprotective strategies for ischemic stroke', JAMA neurology, 71, (5) pp. 634-639. ISSN 2168-6149 (2014) [Refereed Article] DOI: 10.1001/jamaneurol.2013.6299 [eCite] [Details] Citations: Scopus - 40Web of Science - 35 | |
| 2014 | Sutherland BA, Buchan AM, 'The life of Bo K. Siesjo, MD, PhD, 1930-2013', International Journal of Stroke, 9, (1) pp. 2-4. ISSN 1747-4930 (2014) [Letter or Note in Journal] | |
| 2013 | Balami JS, Chen R, Sutherland BA, Buchan AM, 'Thrombolytic Agents for Acute Ischaemic Stroke Treatment: The Past, Present and Future', CNS & neurological disorders drug targets, 12, (2) pp. 145-154. ISSN 1871-5273 (2013) [Refereed Article] DOI: 10.2174/18715273113129990057 [eCite] [Details] Citations: Scopus - 24Web of Science - 14 | |
| 2013 | Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM, 'The exact science of stroke thrombolysis and the quiet art of patient selection', Brain, 136, (Pt 12) pp. 3528-3553. ISSN 0006-8950 (2013) [Refereed Article] DOI: 10.1093/brain/awt201 [eCite] [Details] Citations: Scopus - 46Web of Science - 45 | |
| 2013 | Balami JS, Sutherland BA, Buchan AM, 'Complications Associated with Recombinant Tissue Plasminogen Activator Therapy for Acute Ischaemic Stroke', CNS & neurological disorders drug targets, 12, (2) pp. 155-169. ISSN 1871-5273 (2013) [Refereed Article] DOI: 10.2174/18715273112119990050 [eCite] [Details] Citations: Scopus - 31Web of Science - 27 | |
| 2013 | Sutherland BA, Buchan AM, 'Alteplase treatment does not increase brain injury after mechanical middle cerebral artery occlusion in the rat', Journal of Cerebral Blood Flow and Metabolism, 33, (11) pp. e1-7. ISSN 0271-678X (2013) [Refereed Article] DOI: 10.1038/jcbfm.2013.148 [eCite] [Details] Citations: Scopus - 15Web of Science - 1 | |
| 2013 | Sutherland BA, Harrison JC, Nair SM, Sammut IA, 'Inhalation gases or gaseous mediators as neuroprotectants for cerebral ischaemia', Current drug targets, 14, (1) pp. 56-73. ISSN 1389-4501 (2013) [Refereed Article] DOI: 10.2174/1389450111314010007 [eCite] [Details] Citations: Web of Science - 11 | |
| 2012 | Minnerup J, Sutherland BA, Buchan AM, Kleinschnitz C, 'Neuroprotection for Stroke: Current Status and Future Perspectives', International journal of molecular sciences, 13, (9) pp. 11753-11772. ISSN 1422-0067 (2012) [Refereed Article] DOI: 10.3390/ijms130911753 [eCite] [Details] Citations: Scopus - 122Web of Science - 111 | |
| 2012 | Sutherland BA, Minnerup J, Balami JS, Arba F, Buchan AM, et al., 'Neuroprotection for ischaemic stroke: Translation from the bench to the bedside', International Journal of Stroke, 7, (5) pp. 407-418. ISSN 1747-4930 (2012) [Refereed Article] DOI: 10.1111/j.1747-4949.2012.00770.x [eCite] [Details] Citations: Scopus - 178Web of Science - 167 | |
| 2011 | Nair SM, Rahman RM, Clarkson AN, Sutherland BA, Taurin S, et al., 'Melatonin treatment following stroke induction modulates L-arginine metabolism', Journal of Pineal Research, 51, (3) pp. 313-23. ISSN 0742-3098 (2011) [Refereed Article] DOI: 10.1111/j.1600-079X.2011.00891.x [eCite] [Details] Citations: Scopus - 21Web of Science - 19 | |
| 2011 | Rivers JR, Sutherland BA, Ashton JC, 'Characterization of a rat hypoxia-ischemia model where duration of hypoxia is determined by seizure activity', Journal of Neuroscience Methods, 197, (1) pp. 92-96. ISSN 0165-0270 (2011) [Refereed Article] DOI: 10.1016/j.jneumeth.2011.02.002 [eCite] [Details] Citations: Scopus - 7Web of Science - 6 | |
| 2011 | Sutherland BA, Papadakis M, Chen R-L, Buchan AM, 'Cerebral blood flow alteration in neuroprotection following cerebral ischaemia', The Journal of physiology, 589, (17) pp. 4105-14. ISSN 0022-3751 (2011) [Refereed Article] DOI: 10.1113/jphysiol.2011.209601 [eCite] [Details] Citations: Scopus - 40Web of Science - 38 | |
| 2011 | Sutherland BA, Shaw OM, Clarkson AN, Winburn IC, Errington AC, et al., 'Tin Protoporphyrin Provides Protection Following Cerebral Hypoxia-Ischemia: Involvement of Alternative Pathways', Journal of neuroscience research, 89 pp. 1284-1294. ISSN 0360-4012 (2011) [Refereed Article] DOI: 10.1002/jnr.22661 [eCite] [Details] Citations: Scopus - 6Web of Science - 6 | |
| 2010 | Harston GWJ, Sutherland BA, Kennedy J, Buchan AM, 'The contribution of L-arginine to the neurotoxicity of recombinant tissue plasminogen activator following cerebral ischemia: a review of rtPA neurotoxicity', Journal of Cerebral Blood Flow and Metabolism, 30, (11) pp. 1804-1816. ISSN 0271-678X (2010) [Refereed Article] DOI: 10.1038/jcbfm.2010.149 [eCite] [Details] Citations: Scopus - 33Web of Science - 35 | |
| 2009 | Sutherland BA, Rahman RM, Clarkson AN, Shaw OM, Nair SM, et al., 'Cerebral heme oxygenase 1 and 2 spatial distribution is modulated following injury from hypoxia-ischemia and middle cerebral artery occlusion in rats', Neuroscience Research, 65, (4) pp. 326-334. ISSN 0168-0102 (2009) [Refereed Article] DOI: 10.1016/j.neures.2009.08.007 [eCite] [Details] Citations: Scopus - 27Web of Science - 25 | |
| 2007 | Ashton JC, Rahman RM, Nair SM, Sutherland BA, Glass M, et al., 'Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain', Neuroscience letters, 412, (2) pp. 114-117. ISSN 0304-3940 (2007) [Refereed Article] DOI: 10.1016/j.neulet.2006.10.053 [eCite] [Details] Citations: Scopus - 103Web of Science - 95 | |
| 2006 | Sutherland BA, Rahman RM, Appleton I, 'Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration', Journal of Nutritional Biochemistry, 17, (5) pp. 291 - 306. ISSN 0955-2863 (2006) [Refereed Article] DOI: 10.1016/j.jnutbio.2005.10.005 [eCite] [Details] Citations: Scopus - 246Web of Science - 205 | |
| 2005 | Clarkson AN, Sutherland BA, Appleton I, 'The biology and pathology of hypoxia-ischemia: an update', Archivum immunologiae et therapiae experimentalis, 53, (3) pp. 213-225. ISSN 0004-069X (2005) [Refereed Article] PMID: 15995582 [eCite] [Details] Citations: Web of Science - 50 | |
| 2005 | Kapoor M, Clarkson AN, Sutherland BA, Appleton I, 'The role of antioxidants in models of inflammation: emphasis on L-arginine and arachidonic acid metabolism', Inflammopharmacology, 12, (5-6) pp. 505-19. ISSN 0925-4692 (2005) [Refereed Article] DOI: 10.1163/156856005774382797 [eCite] [Details] Citations: Scopus - 19 | |
| 2005 | Sutherland BA, Shaw OM, Clarkson AN, Jackson DM, Sammut IA, et al., 'Neuroprotective effects of (-)-epigallocatechin gallate after hypoxia-ischemia-induced brain damage: novel mechanisms of action', The FASEB Journal, 19, (2) pp. 258-260. ISSN 1530-6860 (2005) [Refereed Article] DOI: 10.1096/fj.04-2806fje [eCite] [Details] Citations: Scopus - 122Web of Science - 101 |
Chapter in Book
(3 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2017 | Neuhaus AA, Sutherland BA, Buchan AM, 'Targeting Pericytes and the Microcirculation for Ischemic Stroke Therapy', Neuroprotective Therapy for Stroke and Ischemic Disease, Springer International Publishing, PA Lapchack and JH Zhang (ed), Switzerland, pp. 537-556. ISBN 978-3-319-45344-6 (2017) [Research Book Chapter] | |
| 2016 | Hoyte LC, Sutherland BA, Buchan AM, 'Animal models of stroke', Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, J Stein (ed), United States, pp. 1-10. ISBN 978-0-12-809324-5 (2016) [Other Book Chapter] | |
| 2014 | Sutherland BA, Rabie T, Buchan AM, 'Laser Doppler Flowmetry to Measure Changes in Cerebral Blood Flow', Cerebral Angiogenesis Methods and Protocols, Humana Press, R Milner (ed), United Kingdom, pp. 237-248. ISBN 978-1-4939-0320-7 (2014) [Research Book Chapter] DOI: 10.1007/978-1-4939-0320-7_20 [eCite] [Details] Citations: Scopus - 5 |
Conference Publication
(1 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2014 | Sutherland BA, 'Keynote speaker: pre-clinical research the potential therapeutic opportunities for various gases including oxygen', British Hyperbaric Association Annual Meeting, 7-8 November, 2014, Hull, United Kingdom (2014) [Keynote Presentation] |
Other Public Output
(2 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2017 | Landowski LM, Sutherland BA, Eaton E, 'Science in the Pub, Brain edition: Neuropathy, Stroke and Alzheimer's Disease', Afternoons with Helen Shield, ABC Hobart radio, 5 July 2017 (2017) [Media Interview] Co-authors: Landowski LM; Eaton E | |
| 2017 | Sutherland BA, 'Interview with Helen Shield', ABC Nightlife with Helen Shield National Broadcast, 8 February 2017 (2017) [Media Interview] |
Grants & Funding
Brad has previously held grants from the Medical Research Council, John Fell Fund, Wellcome Trust Institutional Strategic Support Fund and Medical Research Fund while working at the University of Oxford (UK).
Funding Summary
Number of grants
16
Total funding
Projects
- Description
- Pericytes are cells that exclusively reside on capillaries and can actively contract or relax to modulate capillary blood flow. Pericytes also have angiogenic, stem cell and phagocytic properties that are important for brain function. In ischaemic stroke, when brain blood flow is depleted, pericytes contract and then die, leading to capillary constriction even after arterial blood flow has been restored. However, after the acute stroke period, pericytes may have an important role in brain repair. Therefore, limiting pericyte contraction acutely while promoting pericyte activity during recovery may be a novel therapeutic strategy for ischaemic stroke.Aim 1 will determine whether acute pericyte constriction of capillaries is implicated in worsening stroke outcome. We will utilise our available NG2-DsRed and PDGFRβ-Cre transgenic mouse lines to selectively kill (ablate) pericytes during acute period post-stroke while using our novel contrast-enhanced ultrasound paradigm to assess blood flow and stroke outcomes. In addition, we will use primary cell culture methods to analyse the secretome of neurons, astrocytes, microglia and endothelial cells following ischaemia and their effects on pericyte function.Aim 2 will investigate whether pericytes drive the recovery process of the brain following stroke. Through our aforementioned transgenic mouse lines, we will selectively ablate pericytes in the recovery phase to determine its influence on stroke outcome. We will use lineage tracing to track pericytes following stroke to determine whether pericytes migrate away from capillaries and differentiate into other cell types. Lastly, we will implant pericytes into the mouse brain post-stroke to promote recovery of the brain.This research will develop pericytes as a therapeutic target for both the acute and recovery phases of stroke, pioneering future ischaemic stroke treatment and providing novel approaches for other vascular diseases and brain injuries.
- Funding
- National Health & Medical Research Council ($862,943)
- Scheme
- Grant-Ideas
- Administered By
- University of Tasmania
- Research Team
- Sutherland BA; Howells DW; Clarkson A; Premilovac D
- Period
- 2021 - 2024
- Grant Reference
- 2003351
- Description
- All drugs given to patients in the setting of stroke are confounded by off-target effects those drugs have on other organs in the body. This pilot project will take advantage of our newly established transcranial ultrasound methods to establish a new way to deliver drugs specifically to the brain regions affected by stroke.
- Funding
- Royal Hobart Hospital Research Foundation ($9,543)
- Scheme
- Grant-Incubator
- Administered By
- University of Tasmania
- Research Team
- Premilovac D; Sutherland BA; Howells DW; Castley H
- Year
- 2020
- Description
- iPSCs can be differentiated into multiple cell types, including neurons and pericytes. We wish to differentiate iPSCs from the same parental lineage into pericytes, a vascular cell with roles in blood-brain barrier maintenance and regulation of cerebral blood flow. The interaction between pericytes and neurons has not been extensively studied, and these models will allow the determination of how these cells interact leading to novel research with relevance to understanding normal brain function and how this contributes to neurodegenerative diseases.
- Funding
- University of Tasmania ($9,980)
- Scheme
- Grant-Research Enhancement Program
- Administered By
- University of Tasmania
- Research Team
- Cook AL; Sutherland BA
- Year
- 2019
- Description
- There are no drugs that improve the outcomes following a stroke. We have recently identified idebenone as a neuroprotective agent during times of energy stress. This pilot project will investigate whether idebenone can be used to reduce the severity of stroke in a pre-clinical animal model.
- Funding
- Royal Hobart Hospital Research Foundation ($9,962)
- Scheme
- Grant-Incubator
- Administered By
- University of Tasmania
- Research Team
- Premilovac D; Sutherland BA; Howells DW; Guven N; Castley H
- Year
- 2019
- Description
- An important action of insulin in the body is to increase blood flow through capillaries in skeletal muscles. This vascular action of insulin occurs rapidly after insulin levels in the blood rise, for example following a meal, to ensure that both insulin and glucose are delivered to muscle cells to enable glucose removal from the blood. Importantly, the vascular action of insulin is lost early in development of insulin resistance and contributes to the progression of the disease. Where and how insulin acts in the vascular tree to increase muscle blood flow remains poorly understood, with insulins potential direct effects on capillaries completely overlooked. The proposed NHMRC Ideas grant will seek to fill this gap in knowledge by demonstrating that insulin acts directly on pericytes, a contractile cell type that wrap around capillaries, to increase capillary blood flow and that these effects are lost during insulin resistance and type 2 diabetes.
- Funding
- University of Tasmania ($16,457)
- Scheme
- Grant-Research Enhancement Program
- Administered By
- University of Tasmania
- Research Team
- Premilovac D; Sutherland BA
- Year
- 2019
- Description
- One possible cause of Alzheimers disease (AD) is narrowing of small blood vessels (capillaries) within the brain, limiting blood flow and energy supply. Pericytes, a cell found only on capillaries, maintain blood flow throughout the brain. In AD, pericytes may die leading to an energy deficit and memory problems. We will test using human brains and animal models whether pericyte loss causes AD and how this is happening. Pericytes could provide a new therapy option for AD.
- Funding
- National Health & Medical Research Council ($857,283)
- Scheme
- Grant-Project
- Administered By
- University of Tasmania
- Research Team
- Sutherland BA; De Luca G
- Period
- 2019 - 2022
- Grant Reference
- 1163384
- Description
- This project aims to understand the mode of cell death induced by a stroke, and determine the capacity for already developed therapeutics to rescue these cells. By saving oligodendrocytes from death after stroke, we aim to reduce the lesion size, but also keep these critical cells in place to support nerve cell survival and function.
- Funding
- Brain Foundation ($30,000)
- Scheme
- Grant-Research
- Administered By
- University of Tasmania
- Research Team
- Cullen CL; Young Kaylene; Sutherland BA
- Year
- 2018
- Description
- This collaboration will be between imaging neuroscientists based in the Wicking DementiaResearch and Education Centre (Canty, Bennett) and a cerebral vascular biologist based inthe School of Medicine (Sutherland). This work will take two different areas of biologicalresearch, our blood vessels and our brains, and investigate how reduced blood flow caninfluence neurons within our brains after an ischemic event typical of vascular dementia.This collaboration will run across two divisions of the College of Health and Medicine: theSchool of Medicine and the Wicking Dementia Centre and include staff at different levels(D/C/B). This collaboration aligns with the University subtheme of complex disease, underthe umbrella of Better Health - investigating the complexity of mixed dementia and linking itwith cardiovascular health. Dementia is a recognised flagship of the College of Health andMedicine, and this project aims to initiate a new area of research in vascular dementia,capitalising on existing researcher strengths. Alison Canty and Brad Sutherland are leaders intheir respective fields of expertise, and seek to work together on this innovative project toestablish a new line of enquiry to determine the origins of the pathology of vasculardementia. If funded, and if successful, we would aim to recruit a HDR student to continuethis work, providing a valuable training opportunity
- Funding
- University of Tasmania ($10,000)
- Scheme
- Grant- Research Enhancement Program
- Administered By
- University of Tasmania
- Research Team
- Canty A; Sutherland BA; Bennett WR
- Year
- 2018
- Description
- Proposed PhD project investigating the role of amyoloid upon axonal dystrophies in the progression of Alzheimers disease
- Funding
- Dementia Australia Research Foundation Ltd ($90,000)
- Scheme
- Grant-Scholarship
- Administered By
- University of Tasmania
- Research Team
- Young Kaylene; Blizzard C; Cullen CL; Sutherland BA
- Period
- 2018 - 2020
- Description
- People with type 2 diabetes are four times more likely to have a stroke. Interestingly, common anti-diabetic drugs seem to improve patient outcomes following a stroke. This project will determine whether anti-diabetic drugs improve brain blood flow dynamics during and after stroke to reduce stroke severity in an animal model of type 2 diabetes.
- Funding
- Royal Hobart Hospital Research Foundation ($24,912)
- Scheme
- Grant-Minor Project
- Administered By
- University of Tasmania
- Research Team
- Premilovac D; Sutherland BA; Burgess JR; Howells DW; Foa LC; Keske MAV
- Year
- 2018
- Description
- Pericytes are contractile cells exclusively residing on the basement membrane of capillaries. These cells have been shown to control cerebralblood flow and energy supply, maintain the blood-brain barrier (BBB) and mediate beta amyloid clearance. An emerging pathologicalmechanism of Alzheimers disease (AD) is the development of vascular dysfunction leading to chronic hypoperfusion, disruption of the BBBand altered beta amyloid clearance. These symptoms are all, in part, controlled by pericytes. Therefore, the degeneration of pericytes may becritical to the development of AD and could represent a novel cellular target for AD therapy. I will utilise my strong background in pericyte andneurovascular biology to:1) Establish a link between pericyte loss and human AD pathology. I will use human post-mortem brains and immunohistochemicaltechniques to assess pericyte degradation and its association with cognitive loss as well as amyloid, tau and vascular pathology.2) Follow changes in pericyte number, coverage and function alongside the development of AD. I will use NG2-DsRed mice that havefluorescent pericytes crossed with an animal model of AD to observe how pericytes change by assessing BBB function and capillary blood flowas AD pathology develops.3) Modulate blood flow and pericyte function directly in NG2-DsRed mice to associate pericyte dysfunction with changes in cognitivebehaviour and AD progression.4) Determine the mechanism of pericyte loss in AD using human pericyte cultures and identify novel compounds that could prevent pericyte degradation and cognitive decline.This research will provide an understanding of the importance of pericyte degeneration to AD pathology and whether pericytes represent a viable target on which further pre-clinical development of pericyte-targeting drugs for AD can begin.
- Funding
- National Health & Medical Research Council ($717,709)
- Scheme
- Fellowship - Boosting Dementia Research Leadership
- Administered By
- University of Tasmania
- Research Team
- Sutherland BA
- Period
- 2018 - 2021
- Grant Reference
- APP1137776
- Description
- This project will assess how pericytes, a specific cell that may control blood flow in placenta, could contribute to restricted growth of babies during pregnancy.
- Funding
- Royal Hobart Hospital Research Foundation ($10,000)
- Scheme
- Grant-Starter
- Administered By
- University of Tasmania
- Research Team
- Sutherland BA; Dargaville PA; Edwards L
- Year
- 2018
- Description
- This project will assess how pericytes, a specific cell that may control blood flow in the brain, are affected by stroke and will identify mechanisms that could be targeted as a treatment strategy for stroke.
- Funding
- Rebecca L Cooper Medical Research Foundation ($100,000)
- Scheme
- Grant
- Administered By
- University of Tasmania
- Research Team
- Sutherland BA
- Period
- 2018 - 2019
- Description
- Fatigue can be much more than just a sense of tiredness. It is also a debilitating symptom of many diseases and disorders, hampering peoples ability to perform the simplest of daily activities. The underlying mechanism of fatigue is unknown. We hypothesise that fatigue is ultimately the result of reduced delivery of energy to the brain. We will assess how energy supply is altered in fatigued brain. A special diet (that supplies an alternative energy source for the brain) will be used to circumvent this energy deficit. We hope to establish how fatigue occurs and offer clues to a simple treatment strategy.
- Funding
- The Mason Foundation ($99,874)
- Scheme
- Grant-Judith Jane Mason & Harold Stannett Williams
- Administered By
- University of Tasmania
- Research Team
- Howells DW; Sutherland BA; Landowski LM; Eaton ED; Allan S; Morten K
- Year
- 2017
- Description
- Stroke is a leading cause of death and chronic disability. Stroke therapeutics developed in animal models fail when translated into human clinical trials, due to flaws inherent in these models. We will break through this translational roadblock by using magnetic microparticles to induce an ischemic stroke that accurately represents human disease
- Funding
- Royal Hobart Hospital Research Foundation ($442,570)
- Scheme
- Grant - Project Grant Funding
- Administered By
- University of Tasmania
- Research Team
- Landowski LM; Howells DW; Castley H; Sutherland BA; Kirkcaldie MTK
- Period
- 2017 - 2019
- Funding
- University of Tasmania ($20,000)
- Scheme
- Grant- Research Enhancement Program
- Administered By
- University of Tasmania
- Research Team
- Sutherland BA
- Year
- 2017
Research Supervision
Brad has co-supervised two PhD students and one Masters student while working at the University Oxford (UK). Brad is currently available to take on supervision of Higher Degree Research Students in the College of Health and Medicine.
Current
10
Current
| Degree | Title | Commenced |
|---|---|---|
| PhD | Pericyte Regulation of Blood Flow in the Brain and its Dysfunction Following Stroke | 2017 |
| PhD | Pericyte Dysfunction Limiting Energy Supply in Alzheimer's Disease | 2018 |
| PhD | Surgical and Anaesthetic Comorbidity in Animal Models of Stroke: A veil over effective drug development | 2018 |
| PhD | How Do Myelinating Cells Alter Brain Circuits to Facilitate Learning? | 2018 |
| PhD | Responsiveness of In Vitro and In Vivo Skeletal Muscle Pericytes to Circulating and Muscle-Derived Paracrine Vasoactive Molecules | 2018 |
| PhD | How Does Cerebral Amyloid Angiopathy Contribute Towards Vascular and Pericyte Dysfunction in Alzheimers Disease? | 2019 |
| PhD | Investigating Cerebrovascular Changes in Insulin Resistance and Type 2 Diabetes | 2019 |
| PhD | Understanding and Preventing Ischemic Injury to Human Neurons: from perinatal ischemia to adult stroke | 2020 |
| PhD | Is Pericyte-specific Neurovascular Dysfunction the Initiator of Multiple Sclerosis? | 2020 |
| PhD | Investigating the Vascular Epigenetic Changes in Alzheimers Disease | 2021 |