Profiles
David Gell
Dave Gell
Postdoctoral Research Fellow
Medical Science 2 , Hobart CBD Campuses
+61 6226 4608 (phone)
Dr Dave Gell is a Research Fellow at the School of Medicine in the College of Health and Medicine. He is a structural biologist.
Biography
Dave studied Natural Sciences at the University of Cambridge. He received his PhD in 2000, on molecular mechanisms of mammalian DNA repair, from the University of Cambridge, under supervision of Professor Stephen Jackson. He carried out postdoctoral work with Professor Joel Mackay at the University of Sydney (2000–2010), where he trained in structural biology and physical biochemistry. Dave combines molecular biology, biochemistry and structural biology to understand protein function.
Career summary
Qualifications
- PhD, University of Cambridge, UK, 2000. Thesis: Molecular analysis of DNA-dependent protein kinase
- MA (Natural Sciences), University of Cambridge, UK. 1993
Memberships
Professional practice
- Australian and New Zealand Society for Magnetic Resonance (current)
- Melbourne Protein Group (current)
- Tasmanian State Representative of the Australian Society for Biochemistry and Molecular Biology (past)
Administrative expertise
- Unit co-ordinator for Human Genetics (CEA301) and Population Health (CEA200) (2013)
- Postgraduate coordinator for Menzies Institute for Medical Research (2011-2013)
Teaching
Protein Structure, Biochemistry, Molecular Biology, Structural Biology, Haemoglobin, Protein Function, Cell Biology
Teaching responsibility
Dr Gell currently teaches:
- Biochemistry A (Pharmacy)(CBA221)
- Molecular Biology and Protein Biochemistry (CBA341)
- Biochemistry: Metabolism and Nutrition (CBA260)
- Research Project in Health and Disease (CBA344)
Research Invitations
Recent speaker invitations:
- Nov 2014 Queensland Protein Group (Brisbane)
- Sept 2014 Combio 2014 Conference (Canberra)
- April 2013 University of Wollongong, School of Chemistry (Wollongong)
View more on Dr David Gell in WARP
Expertise
- Protein function
- Protein structure
- Structural biology
- Metalloproteins
- Nuclear magnetic resonance
- X-ray crystallography
- Physical biochemistry
- Protein engineering
- Haemoglobin
Research Themes
David's research aligns to the University's research theme of Better Health. His research has contributed to understanding how haemoglobin is made in developing red blood cells, and how some pathogenic bacteria can steal iron from human haemoglobin in order to support infection. He is currently engineering proteins with customised functions that can be used to mark and/or control the function of neurons with Dr John Lin, in order to understand brain function and dysfunction.
Collaboration
Dr Gell has collaborations with Mitchell Weiss (Children's Hospital of Philadelphia, USA) and Robert Clubb (UCLA, USA), Joel Mackay (University of Sydney), and Mitchell Guss (University of Sydney) have advanced understand of how haemoglobin is made in developing red blood cells, and the structure and function of haemoglobin-scavenging receptors in pathogenic Staphylococcus aureus.
Awards
- ARC Australian Research Fellow (ARF) (2007-11)
- Australian Society for Biochemistry and Molecular Biology Edman award (2004)
- ARC Australian Post Doctoral Fellow (APD) (2003-05)
- Wellcome Trust International Prize Travelling Post Doctoral Research Fellow (2001-02)
Current projects
- Optogenetic approaches to measure and control neuronal function
- Structure and function of haemoglobin-binding and haem-scavenging proteins in pathogenic bacteria
Fields of Research
- Structural biology (incl. macromolecular modelling) (310112)
- Medical bacteriology (320701)
- Enzymes (310106)
- Medical biotechnology diagnostics (incl. biosensors) (320602)
- Medical biochemistry - proteins and peptides (incl. medical proteomics) (320506)
- Cellular nervous system (320902)
- Cell development, proliferation and death (310102)
- Neurology and neuromuscular diseases (320905)
- Central nervous system (320903)
- Biochemistry and cell biology (310199)
- Crop and pasture protection (incl. pests, diseases and weeds) (300409)
- Epidemiology (420299)
- Haematology (320102)
- Bacteriology (310701)
- Clinical pharmacology and therapeutics (321402)
- Social geography (440610)
- Signal transduction (310111)
- Infectious diseases (320211)
- Medical biochemistry and metabolomics (320599)
- Synthetic biology (310113)
- Human impacts of climate change and human adaptation (410103)
- Biologically active molecules (340401)
- Cell metabolism (310103)
- Cell neurochemistry (310104)
- Plant biology (310899)
- Medical molecular engineering of nucleic acids and proteins (320603)
- Separation science (340109)
- Transition metal chemistry (340211)
Research Objectives
- Expanding knowledge in the biological sciences (280102)
- Clinical health (200199)
- Diagnosis of human diseases and conditions (200101)
- Expanding knowledge in the health sciences (280112)
- Prevention of human diseases and conditions (200104)
- Human pharmaceutical treatments (240803)
- Treatment of human diseases and conditions (200105)
- Sugar (260607)
- Preventive medicine (200412)
- Climate change adaptation measures (excl. ecosystem) (190101)
- Health education and promotion (200203)
- Expanding knowledge in the chemical sciences (280105)
- Human pharmaceutical products (240899)
- Expanding knowledge in the environmental sciences (280111)
- Evaluation of health and support services (200299)
Publications
Dr Gell regularly reviews manuscripts for journals including Journal of Molecular Biology, Biochemistry, Journal of the America Chemical Society (JACS), Blood, European Biophysics Journal, Journal of neurochemistry and Biochimica et Biophysica Acta (BBA).
In total he has over 30 original research articles and several reviews and book chapters that together have received over 2000 citations. The high quality of Dr Gell's work has been recognised by publications in Cell (2004),J Clin Invest (2004, 2007) and Nature (2005).
In addition Dr Gell has a UK patent GB2351494, registered to Kudos Pharmaceuticals (2000), Interactions of Ku polypeptides and application thereof .
Total publications
59
Highlighted publications
(5 outputs)| Year | Type | Citation | Altmetrics |
|---|---|---|---|
| 2015 | Journal Article | Dickson CF, Jacques DA, Clubb RT, Guss JM, Gell DA, 'The structure of haemoglobin bound to the haemoglobin receptor IsdH from Staphylococcus aureus shows disruption of the native α-globin haem pocket', Acta Crystallographica. Section D: Biological Crystallography, 71 pp. 1295-1306. ISSN 0907-4449 (2015) [Refereed Article] DOI: 10.1107/S1399004715005817 [eCite] [Details] Citations: Scopus - 18Web of Science - 17 Co-authors: Dickson CF | |
| 2014 | Journal Article | Dickson CF, Kumar KK, Jacques DA, Malmirchegini GR, Spirig T, et al., 'Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus', Journal of Biological Chemistry, 289, (10) pp. 6728-6738. ISSN 0021-9258 (2014) [Refereed Article] DOI: 10.1074/jbc.M113.545566 [eCite] [Details] Citations: Scopus - 39Web of Science - 37 Co-authors: Dickson CF | |
| 2011 | Journal Article | Kumar KK, Jacques DA, Pishchany G, Caradoc-Davies T, Spirig T, et al., 'Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH', Journal of Biological Chemistry, 286, (44) pp. 38439-38447. ISSN 0021-9258 (2011) [Refereed Article] DOI: 10.1074/jbc.M111.287300 [eCite] [Details] Citations: Scopus - 49Web of Science - 51 Co-authors: Dickson CF | |
| 2005 | Journal Article | Feng L, Zhou S, Gu L, Gell DA, Mackay JP, et al., 'Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem', Nature: International Weekly Journal of Science, 435, (7042) pp. 697-701. ISSN 0028-0836 (2005) [Refereed Article] DOI: 10.1038/nature03609 [eCite] [Details] Citations: Scopus - 94Web of Science - 92 | |
| 2004 | Journal Article | Feng L, Gell DA, Zhou S, Gu L, Kong Y, et al., 'Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin', Cell, 119, (5) pp. 629-640. ISSN 0092-8674 (2004) [Refereed Article] DOI: 10.1016/j.cell.2004.11.025 [eCite] [Details] Citations: Scopus - 135Web of Science - 125 |
Journal Article
(52 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2021 | Atto B, Kunde D, Gell DA, Tristram S, 'Haemophilin-producing strains of Haemophilus haemolyticus protect respiratory epithelia from NTHi colonisation and internalisation', Pathogens, 10, (1) Article 29. ISSN 2076-0817 (2021) [Refereed Article] DOI: 10.3390/pathogens10010029 [eCite] [Details] Citations: Scopus - 2Web of Science - 2 Co-authors: Atto B; Kunde D; Tristram S | |
| 2021 | Atto B, Kunde D, Gell DA, Tristram S, 'Oropharyngeal carriage of hpl-containing Haemophilus haemolyticus predicts lower prevalence and density of NTHi colonisation in healthy adults', Pathogens, 10, (5) pp. 1-9. ISSN 2076-0817 (2021) [Refereed Article] DOI: 10.3390/pathogens10050577 [eCite] [Details] Citations: Scopus - 1Web of Science - 1 Co-authors: Atto B; Kunde D; Tristram S | |
| 2020 | Atto B, Latham R, Kunde D, Gell DA, Tristram S, 'In vitro anti-NTHi activity of haemophilin-producing strains of Haemophilus haemolyticus', Pathogens, 9, (4) Article 243. ISSN 2076-0817 (2020) [Refereed Article] DOI: 10.3390/pathogens9040243 [eCite] [Details] Citations: Scopus - 5Web of Science - 5 Co-authors: Atto B; Latham R; Kunde D; Tristram S | |
| 2019 | Latham RD, Torrado M, Atto B, Walshe JL, Wilson R, et al., 'A heme-binding protein produced by Haemophilus haemolyticus inhibits non-typeable Haemophilus influenzae', Molecular Microbiology, 113, (2) pp. 381-398. ISSN 0950-382X (2019) [Refereed Article] DOI: 10.1111/mmi.14426 [eCite] [Details] Citations: Scopus - 10Web of Science - 10 Co-authors: Latham RD; Atto B; Wilson R; Tristram S | |
| 2018 | Gao J-L, Kwan AH, Yammine A, Zhou X, Trewhella J, et al., 'Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis', Nature Communications, 9 Article 4097. ISSN 2041-1723 (2018) [Refereed Article] DOI: 10.1038/s41467-018-06470-0 [eCite] [Details] Citations: Scopus - 14Web of Science - 14 Co-authors: Horne J | |
| 2018 | Gell DA, 'Structure and function of haemoglobins', Blood Cells, Molecules, and Diseases, 70 pp. 13-42. ISSN 1079-9796 (2018) [Refereed Article] DOI: 10.1016/j.bcmd.2017.10.006 [eCite] [Details] Citations: Scopus - 83Web of Science - 73 | |
| 2018 | Sjodt M, Macdonald R, Marshall JD, Clayton J, Olson JS, et al., 'Energetics underlying hemin extraction from human hemoglobin by Staphylococcus aureus', Journal of Biological Chemistry, 293, (18) pp. 6942-6957. ISSN 0021-9258 (2018) [Refereed Article] DOI: 10.1074/jbc.RA117.000803 [eCite] [Details] Citations: Scopus - 17Web of Science - 17 | |
| 2018 | Wanandy T, Wilson R, Gell D, Rose HE, Gueven N, et al., 'Towards complete identification of allergens in Jack Jumper (Myrmecia pilosula) ant venom and their clinical relevance: An immunoproteomic approach', Clinical and Experimental Allergy, 48, (9) pp. 1222-1234. ISSN 1365-2222 (2018) [Refereed Article] DOI: 10.1111/cea.13224 [eCite] [Details] Citations: Scopus - 10Web of Science - 10 Co-authors: Wanandy T; Wilson R; Gueven N; Davies NW; Brown SGA | |
| 2017 | Latham RD, Gell DA, Fairbairn RL, Lyons AB, Shukla SD, et al., 'An isolate of Haemophilus haemolyticus produces a bacteriocin-like substance that inhibits the growth of nontypeable Haemophilus influenzae', International Journal of Antimicrobial Agents, 49, (4) pp. 503-506. ISSN 0924-8579 (2017) [Refereed Article] DOI: 10.1016/j.ijantimicag.2016.12.010 [eCite] [Details] Citations: Scopus - 14Web of Science - 14 Co-authors: Latham RD; Lyons AB; Shukla SD; Tristram SG | |
| 2016 | Choo JM, Cheung JK, Wisniewski JA, Steer DL, Bulach DM, et al., 'The NEAT domain-containing proteins of Clostridium perfringens bind heme', PLoS One, 11, (9) Article e0162981. ISSN 1932-6203 (2016) [Refereed Article] DOI: 10.1371/journal.pone.0162981 [eCite] [Details] Citations: Scopus - 10Web of Science - 7 | |
| 2016 | Saederup KL, Stodkilde K, Graversen JH, Dickson CF, Etzerodt A, et al., 'The Staphylococcus aureus protein IsdH inhibits host hemoglobin scavenging to promote heme acquisition by the pathogen', Journal of Biological Chemistry, 291, (46) pp. 23989-23997. ISSN 0021-9258 (2016) [Refereed Article] DOI: 10.1074/jbc.M116.755934 [eCite] [Details] Citations: Scopus - 20Web of Science - 18 Co-authors: Dickson CF | |
| 2016 | Shukla SD, Fairbairn RL, Gell DA, Latham RD, Sohal SS, et al., 'An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke', International Journal of Chronic Obstructive Pulmonary Disease, 11, (1) pp. 1647-1655. ISSN 1178-2005 (2016) [Refereed Article] DOI: 10.2147/COPD.S108698 [eCite] [Details] Citations: Scopus - 32Web of Science - 30 Co-authors: Shukla SD; Latham RD; Sohal SS; Walters EH; O'Toole RF | |
| 2015 | Dickson CF, Jacques DA, Clubb RT, Guss JM, Gell DA, 'The structure of haemoglobin bound to the haemoglobin receptor IsdH from Staphylococcus aureus shows disruption of the native α-globin haem pocket', Acta Crystallographica. Section D: Biological Crystallography, 71 pp. 1295-1306. ISSN 0907-4449 (2015) [Refereed Article] DOI: 10.1107/S1399004715005817 [eCite] [Details] Citations: Scopus - 18Web of Science - 17 Co-authors: Dickson CF | |
| 2015 | Sjodt M, Macdonald R, Spirig T, Chan AH, Dickson CF, et al., 'The PRE-derived NMR model of the 38.8-kDa tri-domain IsdH protein from Staphylococcus aureus suggests that it adaptively recognizes human hemoglobin', Journal of Molecular Biology, 428, (6) pp. 1107-1129. ISSN 0022-2836 (2015) [Refereed Article] DOI: 10.1016/j.jmb.2015.02.008 [eCite] [Details] Citations: Scopus - 18Web of Science - 19 Co-authors: Dickson CF | |
| 2014 | Dickson CF, Kumar KK, Jacques DA, Malmirchegini GR, Spirig T, et al., 'Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus', Journal of Biological Chemistry, 289, (10) pp. 6728-6738. ISSN 0021-9258 (2014) [Refereed Article] DOI: 10.1074/jbc.M113.545566 [eCite] [Details] Citations: Scopus - 39Web of Science - 37 Co-authors: Dickson CF | |
| 2014 | Kumar KK, Jacques DA, Guss JM, Gell DA, 'The structure of α-haemoglobin in complex with a haemoglobin-binding domain from Staphylococcus aureus reveals the elusive α-haemoglobin dimerization interface', Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 70, (8) pp. 1032-1037. ISSN 1744-3091 (2014) [Refereed Article] DOI: 10.1107/S2053230X14012175 [eCite] [Details] Citations: Scopus - 8Web of Science - 7 | |
| 2014 | Pishchany G, Sheldon JR, Dickson CF, Alam MT, Read TD, et al., 'IsdB-dependent hemoglobin binding is required for acquisition of heme by Staphylococcus aureus', Journal of Infectious Diseases, 209, (11) pp. 1764-1772. ISSN 0022-1899 (2014) [Refereed Article] DOI: 10.1093/infdis/jit817 [eCite] [Details] Citations: Scopus - 54Web of Science - 56 Co-authors: Dickson CF | |
| 2013 | Cordina NM, Liew CK, Gell DA, Fajer PG, MacKay JP, et al., 'Effects of calcium binding and the hypertrophic cardiomyopathy A8V mutation on the dynamic equilibrium between closed and open conformations of the regulatory N-domain of isolated cardiac troponin C', Biochemistry, 52, (11) pp. 1950-1962. ISSN 0006-2960 (2013) [Refereed Article] DOI: 10.1021/bi4000172 [eCite] [Details] Citations: Scopus - 27Web of Science - 25 | |
| 2013 | Dickson CF, Rich AM, D'Avigdor WMH, Collins DAT, Lowry JA, et al., 'α-Hemoglobin-stabilizing Protein (AHSP) perturbs the proximal heme pocket of oxy-α-hemoglobin and weakens the iron-oxygen bond', Journal of Biological Chemistry, 288, (27) pp. 19986-20001. ISSN 0021-9258 (2013) [Refereed Article] DOI: 10.1074/jbc.M112.437509 [eCite] [Details] Citations: Scopus - 13Web of Science - 13 Co-authors: Dickson CF | |
| 2013 | Spirig T, Malmirchegini GR, Zhang J, Robson SA, Sjodt M, et al., 'Staphylococcus aureus uses a novel multidomain receptor to break apart human hemoglobin and steal its heme', Journal of Biological Chemistry, 288, (2) pp. 1065-1078. ISSN 0021-9258 (2013) [Refereed Article] DOI: 10.1074/jbc.M112.419119 [eCite] [Details] Citations: Scopus - 44Web of Science - 44 Co-authors: Dickson CF | |
| 2013 | Thom CS, Dickson CF, Gell DA, Weiss MJ, 'Hemoglobin variants: biochemical properties and clinical correlates', Cold Spring Harbor Perspectives in Medicine, 3, (3) pp. 1-22. ISSN 2157-1422 (2013) [Refereed Article] DOI: 10.1101/cshperspect.a011858 [eCite] [Details] Citations: Scopus - 160Web of Science - 138 Co-authors: Dickson CF | |
| 2012 | Cordina NM, Liew CK, Gell DA, Fajer PG, Mackay JP, et al., 'Interdomain orientation of cardiac Troponin C characterized by paramagnetic relaxation enhancement NMR reveals a compact state', Protein Science, 21, (9) pp. 1376-1387. ISSN 1469-896X (2012) [Refereed Article] DOI: 10.1002/pro.2124 [eCite] [Details] Citations: Scopus - 15Web of Science - 14 | |
| 2012 | Khandros E, Mollan TL, Yu X, Wang X, Yao Y, et al., 'Insights into Hemoglobin Assembly through in Vivo Mutagenesis of α-Hemoglobin Stabilizing Protein', Journal of Biological Chemistry, 287, (14) pp. 11325-11337. ISSN 0021-9258 (2012) [Refereed Article] DOI: 10.1074/jbc.M111.313205 [eCite] [Details] Citations: Scopus - 19Web of Science - 18 | |
| 2012 | Pankhurst MW, Gell DA, Butler CW, Kirkcaldie MTK, West AK, et al., 'Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury', Pl o S One, 7, (2) Article e31185. ISSN 1932-6203 (2012) [Refereed Article] DOI: 10.1371/journal.pone.0031185 [eCite] [Details] Citations: Scopus - 14Web of Science - 12 Co-authors: Pankhurst MW; Butler CW; Kirkcaldie MTK; West AK; Chung RS | |
| 2011 | Kumar KK, Jacques DA, Pishchany G, Caradoc-Davies T, Spirig T, et al., 'Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH', Journal of Biological Chemistry, 286, (44) pp. 38439-38447. ISSN 0021-9258 (2011) [Refereed Article] DOI: 10.1074/jbc.M111.287300 [eCite] [Details] Citations: Scopus - 49Web of Science - 51 Co-authors: Dickson CF | |
| 2010 | Kumar KK, Dickson CF, Weiss MJ, Mackay JP, Gell DA, 'AHSP (α-haemoglobin-stabilizing protein) stabilizes apo-α-haemoglobin in a partially folded state', Biochemical Journal, 432, (2) pp. 275-282. ISSN 0264-6021 (2010) [Refereed Article] DOI: 10.1042/BJ20100642 [eCite] [Details] Citations: Scopus - 13Web of Science - 13 Co-authors: Dickson CF | |
| 2010 | Schwalbe M, Dutta K, Libich DS, Venugopal H, Claridge JK, et al., 'Two-state conformational equilibrium in the Par-4 leucine zipper domain', Proteins: Structure, Function, and Genetics, 78, (11) pp. 2433-2449. ISSN 0887-3585 (2010) [Refereed Article] DOI: 10.1002/prot.22752 [eCite] [Details] Citations: Scopus - 6Web of Science - 6 | |
| 2010 | Tao L, Xu J, Gell D, Davis TP, 'Synthesis, Characterization, and Bioactivity of Mid-Functional PolyHPMA-Lysozyme Bioconjugates ', Macromolecules, 43, (8) pp. 3721-3727. ISSN 0024-9297 (2010) [Refereed Article] DOI: 10.1021/ma100142w [eCite] [Details] Citations: Scopus - 51Web of Science - 50 | |
| 2009 | Gell DA, Feng L, Zhou S, Jeffrey PD, Bendak K, et al., 'A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin', Journal of Biological Chemistry, 284, (43) pp. 29462-29469. ISSN 0021-9258 (2009) [Refereed Article] DOI: 10.1074/jbc.M109.027045 [eCite] [Details] Citations: Scopus - 18Web of Science - 17 | |
| 2007 | Yu X, Kong Y, Dore LC, Abdulmalik O, Katein AM, et al., 'An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis', Journal of Clinical Investigation, 117, (7) pp. 1856-1865. ISSN 0021-9738 (2007) [Refereed Article] DOI: 10.1172/JCI31664 [eCite] [Details] Citations: Scopus - 93Web of Science - 91 | |
| 2006 | Gell DA, Westman BJ, Gorman D, Liew C, Welch JJ, et al., 'A novel haem-binding interface in the 22 kDa haem-binding protein p22HBP', Journal of Molecular Biology, 362, (2) pp. 287-297. ISSN 0022-2836 (2006) [Refereed Article] DOI: 10.1016/j.jmb.2006.07.010 [eCite] [Details] Citations: Scopus - 8Web of Science - 8 | |
| 2005 | Feng L, Zhou S, Gu L, Gell DA, Mackay JP, et al., 'Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem', Nature: International Weekly Journal of Science, 435, (7042) pp. 697-701. ISSN 0028-0836 (2005) [Refereed Article] DOI: 10.1038/nature03609 [eCite] [Details] Citations: Scopus - 94Web of Science - 92 | |
| 2005 | Weiss MJ, Zhou S, Feng L, Gell DA, Mackay JP, et al., 'Role of alpha hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia', New York Academy of Sciences. Annals, 1054, (1) pp. 103-117. ISSN 0077-8923 (2005) [Refereed Article] DOI: 10.1196/annals.1345.013 [eCite] [Details] Citations: Scopus - 41Web of Science - 38 | |
| 2004 | Feng L, Gell DA, Zhou S, Gu L, Kong Y, et al., 'Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin', Cell, 119, (5) pp. 629-640. ISSN 0092-8674 (2004) [Refereed Article] DOI: 10.1016/j.cell.2004.11.025 [eCite] [Details] Citations: Scopus - 135Web of Science - 125 | |
| 2004 | Kong Y, Zhou S, Kihm AJ, Katein AM, Yu X, et al., 'Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia', Journal of Clinical Investigation, 114, (10) pp. 1457-1466. ISSN 0021-9738 (2004) [Refereed Article] DOI: 10.1172/JCI200421982 [eCite] [Details] Citations: Scopus - 110Web of Science - 125 | |
| 2003 | Kwan AH, Gell DA, Verger A, Crossley M, Matthews JM, et al., 'Engineering a protein scaffold from a PHD finger', Structure, 11, (7) pp. 803-813. ISSN 0969-2126 (2003) [Refereed Article] DOI: 10.1016/S0969-2126(03)00122-9 [eCite] [Details] Citations: Scopus - 53Web of Science - 52 | |
| 2002 | Gell D, Kong Y, Eaton SA, Weiss MJ, Mackay JP, 'Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein', Journal of Biological Chemistry, 277, (43) pp. 40602-40609. ISSN 0021-9258 (2002) [Refereed Article] DOI: 10.1074/jbc.M206084200 [eCite] [Details] Citations: Scopus - 100Web of Science - 88 | |
| 2002 | Kowalski K, Liew CK, Matthews JM, Gell DA, Crossley M, et al., 'Characterization of the conserved interaction between GATA and FOG family proteins', Journal of Biological Chemistry, 277, (38) pp. 35720-35729. ISSN 0021-9258 (2002) [Refereed Article] DOI: 10.1074/jbc.M204663200 [eCite] [Details] Citations: Scopus - 21Web of Science - 18 | |
| 2002 | Sharpe BK, Matthews JM, Kwan AH, Newton A, Gell DA, et al., 'A new zinc binding fold underlines the versatility of zinc binding modules in protein evolution ', Structure, 10, (5) pp. 639-648. ISSN 0969-2126 (2002) [Refereed Article] DOI: 10.1016/S0969-2126(02)00757-8 [eCite] [Details] Citations: Scopus - 22Web of Science - 20 | |
| 2002 | Westman BJ, Mackay JP, Gell D, 'Ikaros: a key regulator of haematopoiesis', International Journal of Biochemistry and Cell Biology, 34, (10) pp. 1304-1307. ISSN 1357-2725 (2002) [Refereed Article] DOI: 10.1016/S1357-2725(02)00070-5 [eCite] [Details] Citations: Scopus - 27Web of Science - 23 | |
| 2001 | Herceg Z, Hulla W, Gell D, Cuenin C, Lleonart M, et al., 'Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression', Nature Genetics, 29, (2) pp. 206-211. ISSN 1061-4036 (2001) [Refereed Article] DOI: 10.1038/ng725 [eCite] [Details] Citations: Scopus - 105Web of Science - 103 | |
| 2000 | Errami A, Overkamp WJ, He DM, Friedl AA, Gell DA, et al., 'A new X-ray sensitive CHO cell mutant of ionizing radiation group 7,XR-C2, that is defective in DSB repair but has only a mild defect in V(D)J recombination ', Mutation Research - DNA Repair, 461, (1) pp. 59-69. ISSN 0921-8777 (2000) [Refereed Article] DOI: 10.1016/S0921-8777(00)00038-0 [eCite] [Details] Citations: Scopus - 15Web of Science - 15 | |
| 1999 | Gell D, Jackson SP, 'Mapping of protein-protein interactions within the DNA-dependent protein kinase complex', Nucleic Acids Research, 27, (17) pp. 3494-3502. ISSN 0305-1048 (1999) [Refereed Article] DOI: 10.1093/nar/27.17.3494 [eCite] [Details] Citations: Scopus - 183Web of Science - 173 | |
| 1998 | Priestley A, Beamish HJ, Gell D, Amatucci AG, Muhlmann-Diaz MC, et al., 'Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20', Nucleic Acids Research, 26, (8) pp. 1965-1973. ISSN 0305-1048 (1998) [Refereed Article] DOI: 10.1093/nar/26.8.1965 [eCite] [Details] Citations: Scopus - 77Web of Science - 75 | |
| 1998 | Taccioli GE, Amatucci AG, Beamish HJ, Gell D, Xiang XH, et al., 'Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity ', Immunity, 9, (3) pp. 355-366. ISSN 1074-7613 (1998) [Refereed Article] DOI: 10.1016/S1074-7613(00)80618-4 [eCite] [Details] Citations: Scopus - 273Web of Science - 265 | |
| 1997 | Badie C, Goodhardt M, Waugh A, Doyen N, Foray N, et al., 'A DNA double-strand break defective fibroblast cell line (180BR) derived from a radiosensitive patient represents a new mutant phenotype ', Cancer Research, 57, (20) pp. 4600-4607. ISSN 0008-5472 (1997) [Refereed Article] Citations: Web of Science - 47 | |
| 1997 | Raats JM, Gell D, Vickers L, Heasman J, Wylie C, 'Modified mRNA rescue of maternal CK1/8 mRNA depletion in Xenopus oocytes', Antisense and Nucleic Acid Drug Development, 7, (4) pp. 263-277. ISSN 1087-2906 (1997) [Refereed Article] DOI: 10.1089/oli.1.1997.7.263 [eCite] [Details] Citations: Scopus - 6Web of Science - 6 | |
| 1997 | Singleton BK, Priestley A, Steingrimsdottir H, Gell D, Blunt T, et al., 'Molecular and biochemical characterization of xrs mutants defective in Ku80', Molecular and Cellular Biology, 17, (3) pp. 1264-1273. ISSN 0270-7306 (1997) [Refereed Article] DOI: 10.1128/MCB.17.3.1264 [eCite] [Details] Citations: Scopus - 165Web of Science - 159 | |
| 1996 | Blunt T, Gell D, Fox M, Taccioli GE, Lehmann AR, et al., 'Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse ', National Academy of Sciences of The United States of America. Proceedings, 93, (19) pp. 10285-10290. ISSN 0027-8424 (1996) [Refereed Article] DOI: 10.1073/pnas.93.19.10285 [eCite] [Details] Citations: Scopus - 306Web of Science - 292 | |
| 1995 | Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, et al., 'DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product ', Cell, 82, (5) pp. 849-856. ISSN 0092-8674 (1995) [Refereed Article] DOI: 10.1016/0092-8674(95)90482-4 [eCite] [Details] Citations: Scopus - 670Web of Science - 668 | |
| 1995 | Miller RD, Hogg J, Ozaki JH, Gell D, Jackson SP, et al., 'Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus', National Academy of Sciences of The United States of America. Proceedings, 92, (23) pp. 10792-10795. ISSN 0027-8424 (1995) [Refereed Article] DOI: 10.1073/pnas.92.23.10792 [eCite] [Details] Citations: Scopus - 60Web of Science - 53 | |
| 1994 | Meadows LA, Gell D, Broadie K, Gould AP, White RA, 'The cell adhesion molecule, connectin, and the development of the Drosophila neuromuscular system', Journal of Cell Science, 107 pp. 321-328. ISSN 0021-9533 (1994) [Refereed Article] Citations: Web of Science - 53 |
Chapter in Book
(4 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2017 | Gell DA, Kwan AN, Mackay JP, 'NMR Spectroscopy in the Analysis of Protein-Protein Interactions', Modern Magnetic Resonance, Springer International Publishing, GA Webb (ed), pp. 1-34. ISBN 978-3-319-28275-6 (2017) [Other Book Chapter] | |
| 2012 | Gell DA, Grant RP, Mackay JP, 'The detection and quantitation of protein oligomerization', Advances in Experimental Medicine and Biology: Protein Dimerization and Oligomerization in Biology, Springer, JM Matthews (ed), New York, United States, pp. 19-41. ISBN 978-146143228-9 (2012) [Research Book Chapter] | |
| 2006 | Gell DA, Mackay JP, 'NMR spectroscopy in the analysis of protein-protein interactions', Modern Magnetic Resonance, Springer, GA Webb (ed), Dordrecht, The Netherlands, pp. 1321-1328. ISBN 978-1-4020-3894-5 (2006) [Research Book Chapter] | |
| 2003 | Gell DA, Crossley M, Mackay JP, 'Zinc-finger Genes', Encyclopedia of the Human Genome, John Wily & Sons Ltd, DN Cooper (ed), Chichester, pp. 823-828. ISBN 978-0-470-01618-3 (2003) [Research Book Chapter] |
Conference Publication
(3 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2019 | Atto B, Kunde D, Latham R, Gell D, Tristram S, 'Exploiting the struggle for haem: A new respiratory probiotic candidate?', Australian Society for Microbiology Annual Scientific Meeting, 30 June - 1 July, Adelaide, South Australia (2019) [Conference Extract] Co-authors: Atto B; Kunde D; Latham R; Tristram S | |
| 2018 | Latham RD, Del Rey MT, Walshe J, Atto B, Guss JM, et al., 'Haem at the interface between pathogenic and commensal bacterial species in the human respiratory tract', ComBio2018, 23-26 September, Sydney, NSW, pp. 37. (2018) [Conference Extract] Co-authors: Latham RD; Atto B; Tristram SG | |
| 2016 | Shukla SD, Fairbairn R, Gell DA, Smith JA, Walters EH, et al., 'An antagonist of the platelet-activating factor receptor inhibits streptococcus pneumoniae and non-typeable haemophilus influenzae infection of human bronchial epithelial cells exposed to cigarette smoke', Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, 1-6 April 2016, Perth, Australia (2016) [Conference Extract] Co-authors: Shukla SD; Smith JA; Walters EH; O'Toole RF |
Grants & Funding
Over his research career Dr Gell has been lead or co-CI on National Competitive Grants projects worth >$2.5M (since 2002). He has won ~ $60,000 from competitive internal schemes. In 2011, he played a steering role as a CI in a successful ARC LIEF grant ($630,000) for a 600 MHz NMR spectrometer at the University of Tasmania.
Funding Summary
Number of grants
14
Total funding
Projects
- Description
- Funding to continue research on the development of the GreyScan TVD-1 system for trace virus detection. A first round of research supported by CSIRO innovations connection funding has completed. Additional work is required to continue the research required for product scope and development.
- Funding
- GreyScan Pty Ltd ($146,415)
- Scheme
- Contract Research
- Administered By
- University of Tasmania
- Research Team
- Breadmore MC; Gell DA; King AE; Flies AS; Wilson CR; Flies E; Liu G
- Year
- 2021
- Description
- Recently, proteins have been identified in the blood that can act as indicators that a person is at risk of developing dementia or neurodegenerative disease. This opens a window of opportunity for early intervention and preventative strategies. At present these proteins need to be measured using equipment not available to health professionals and the current methods use antibodies as biosensors. Antibodies are unstable, difficult to produce and expensive, and therefore not suited for wide-spread distribution of detection devices. Aptamers are single-stranded oligonucleotide (DNA or RNA) molecules, which can bind to target molecules with high affinity and specificity. They are ideal for use as biosensors in point-of-care devices as they are stable at room temperature and are cheap to produce. Our goal is to develop biomarker detection devices that are suitable for population-based screening. This project will develop aptamers to key biomarker indicators of brain health such as neurofilament light chain and tau.
- Funding
- Perpetual Trustees ($119,386)
- Scheme
- Grant-Trust Fund
- Administered By
- University of Tasmania
- Research Team
- King AE; Breadmore MC; Gell DA; Collins J; Shigdar S
- Year
- 2021
- Description
- With GreyScan will repurpose the ETD-100 trace explosives system to detect viruses and create a new product range, TVD 1
- Funding
- GreyScan Pty Ltd ($259,020)
- Scheme
- Contract Research
- Administered By
- University of Tasmania
- Research Team
- Breadmore MC; King AE; Karupiah G; Flies AS; Wilson CR; Flies E; Gell DA
- Year
- 2020
- Description
- Neutrophin signalling is important in learning and memory, neural development and neuronal regeneration. The importance of neurotrophin factors has been highlighted by their therapeutic potential as treatments of neurological disorders and neural injury. The neurotrophin factor BDNF, acting through TrkB receptor, has crucial roles in memory formation. TrkB receptor is a tyrosine receptor kinase that can activate multiple intracellular signalling cascades, named ERK, AKT and PLCgamma pathways. We have successfully generated an optogenetic tool that can mimic the activation of TrkB receptor, leading to the activation of these cascades. We have also generated modified versions that activate ERK and AKT but not PLCgamma, or activates PLCgamma without direct activation of ERK and AKT. Our preliminary results demonstrate that AMPA-type glutamate receptors are upregulated on the neuronal membrane after the activation of our optogenetic TrkB tool, similar to that observed with long-term potentiation (LTP). LTP is believed to be the cellular event of learning, hence our tool could potentially enhance learning in behaving animals. This proposal will utilise these tools to investigate the roles of the different signalling pathways associated with TrkB receptor on LTP induction and maintenance, understand the effects of TrkB signalling on presynaptic release and correlate these findings to the effects on learning in behaving animals. We will also develop novel intracellular nanobodies towards TrkB that would permit manipulation at the correct subcellular localisation by locating our tools to the endogenous TrkB receptors. These novel optogenetic tools will provide novel insights into the important process of learning and memory formation. This knowledge will have important implication for the utilisation of BDNF as therapeutic agents and building a new cellular model of learning and memory formation.
- Funding
- National Health & Medical Research Council ($496,955)
- Scheme
- Grant-Ideas
- Administered By
- University of Tasmania
- Research Team
- Lin J; Gell DA
- Period
- 2020 - 2022
- Grant Reference
- 1185565
- Description
- We have discovered a strain of a harmless bacterial species that lives in the throats of healthy people that produces a novel substance that inhibits the growth of the respiratory pathogen - Haemophilus influenzae. The study involves an evaluation of the potential of this strain as a respiratory probiotic.
- Funding
- Clifford Craig Foundation ($19,000)
- Scheme
- Grant
- Administered By
- University of Tasmania
- Research Team
- Tristram SG; Kunde DA; Gell DA
- Year
- 2018
- Funding
- The Select Foundation ($8,810)
- Scheme
- Grant-Small Grants Scheme
- Administered By
- University of Tasmania
- Research Team
- Dickson CF; Gell DA
- Year
- 2012
- Funding
- National Health & Medical Research Council ($341,175)
- Scheme
- Grant-Project
- Administered By
- University of Tasmania
- Research Team
- Foa LC; Small DH; Gell DA
- Period
- 2012 - 2014
- Grant Reference
- 1024145
- Description
- This proposal seeks support for a high resolution Nuclear Magnetic Resonance spectrometer with a liquid chromatographic separation module for the Central Science Laboratory at the University of Tasmania. This will be a shared facility supporting a diversity of researchers in the broader Tasmanian scientific community. Access to recent advances in instrument technology is essential to support internationally competitive research programs into areas of Human health, plant biology and agriculture, aquaculture, food science, materials technology, separation science and chemical synthesis.
- Funding
- Australian Research Council ($630,000)
- Scheme
- Grant-Linkage Infrastructure
- Administered By
- University of Tasmania
- Research Team
- Reid JB; Hilder EF; Gell DA; McGuinness DS; Ross JJ
- Year
- 2012
- Grant Reference
- LE1210018
- Funding
- University of Tasmania ($51,000)
- Scheme
- Grant-Rising Stars Round 3
- Administered By
- University of Tasmania
- Research Team
- Gell DA
- Period
- 2011 - 2013
- Funding
- Australian Synchrotron ($1,415)
- Scheme
- Grant-Travel
- Administered By
- University of Tasmania
- Research Team
- Gell DA
- Year
- 2011
- Funding
- Menzies Institute for Medical Research ($24,000)
- Scheme
- Consultancy
- Administered By
- University of Tasmania
- Research Team
- Gell DA
- Year
- 2010
- Funding
- Australian Research Council ($240,000)
- Scheme
- Grant-Discovery Projects
- Administered By
- Australian Research Council
- Research Team
- Gell DA
- Period
- 2010 - 2011
- Grant Reference
- DP0773140
- Funding
- National Health & Medical Research Council ($392,750)
- Scheme
- Grant-Project
- Administered By
- University of Tasmania
- Research Team
- Chung RS; West AK; Gell DA; Cheung NS
- Period
- 2009 - 2011
- Grant Reference
- 544913
- Funding
- National Health & Medical Research Council ($254,250)
- Scheme
- Grant-Project
- Administered By
- National Health & Medical Research Council
- Research Team
- Gell DA; Weiss M
- Period
- 2009 - 2011
- Grant Reference
- 570876
Research Supervision
Dr Gell has successfully supervised 2 PhD candidates to completion, both of whom have gone on to secure prestigious post doctoral positions. Dr Gell currently supervises several PhD and Honours students.
Completed
7
Completed
| Degree | Title | Completed |
|---|---|---|
| PhD | Potential Therapeutic Value of Normal Throat Bacteria that Produce a Novel Inhibitory Substance for the Prevention of Respiratory Infections Candidate: Brianna Anise Atto | 2022 |
| PhD | Optogenetic Manipulation of Calcineurin Signalling Candidate: Elise Joanna Devenish | 2019 |
| PhD | Dissecting the Pharmaceutical and Immunological Aspects of Myrmecia pilosula (Jack Jumper) Ant Venom Immunotherapy Candidate: Stephanus Troy Wanandy | 2019 |
| PhD | Development of Optogenetic Approaches to Modulate Synaptic Plasticity in the Postsynaptic Cells Candidate: Agnieszka Miroslawa Zbela | 2019 |
| PhD | An Investigation of the Inhibition of Non-typeable Haemophilus influenzae, by Substances Secreted by Haemophilus haemolyticus Candidate: Roger Declan Latham | 2018 |
| PhD | The Role of the CC-Chemokine Receptor 6, CCR6, in B Cell Differentiation During the Humoral Immune Response Candidate: Jennifer Bannan | 2015 |
| PhD | Molecular Mechanisms Used by Staphylococcus Aureus to Access Iron from Human Haemoglobin Candidate: Claire Frances Dickson | 2014 |