Profiles

Jackie Leung

UTAS Home Dr Jacqueline Leung

Jacqueline Leung

Bill Gole Postdoctoral Research Fellow
Wicking Dementia Research & Education Centre

Room 415 (Level 4) , Medical Science 1

+61 3 6226 2687 (phone)

Jaqueline.Leung@utas.edu.au

Career summary

Qualifications

  • PhD, University of Tasmania, Australia, 2012, The Role of Metallothionein I/II in promoting axonal sprouting in both central nervous system and peripheral nervous system
  • BBiotech (1st Class Hons), University of Tasmania, 2005, The response of Olfactory ensheathing cells towards microorganisms

Languages (other than English)

  • Cantonese (fluent)
  • Mandarin (fluent)

Memberships

Professional practice

  • The Golden Key International Honours Society
  • Australia Neuroscience Society
  • Society for Neuroscience

Teaching

Neuroscience, Biochemistry, Human Biology

View more on Dr Jacqueline Leung in WARP

Expertise

  • Molecular Biology
  • Neuroscience
  • Motor Neuron Diseases
  • Dementia Research
  • Medical Research

Awards

  • The Adam J Berry Memorial Fund (Australia Academy of Science) in conjunction with The Foundation for the National Institutes of Health, USA
  • Finalist in the TEMCO Science and Technology Award (Part of 2012/2013 Southern Cross Young Achiever Awards)
  • Bill Gole Postdoctoral Research Fellowship from the Motor Neuron Disease Research Australia
  • Project Grant from the Alzheimer's Australia Dementia Research Fund
  • Research Enhancement Grant Scheme (REGS) from the University of Tasmania

Current projects

  1. The Role of Oligodendrocytes in Amyotrophic Lateral Sclerosis
  2. The Role of Oligodendrocytes in Frontal Temporal Lobar Dementia

Fields of Research

  • Central nervous system (320903)
  • Cellular nervous system (320902)
  • Neurology and neuromuscular diseases (320905)
  • Peripheral nervous system (320906)
  • Clinical sciences (320299)
  • Neurosciences (320999)
  • Cell development, proliferation and death (310102)
  • Gene and molecular therapy (320601)
  • Ophthalmology (321201)
  • Gene expression (incl. microarray and other genome-wide approaches) (310505)

Research Objectives

  • Clinical health (200199)
  • Expanding knowledge in the environmental sciences (280111)
  • Expanding knowledge in the biological sciences (280102)

Publications

Total publications

12

Journal Article

(11 outputs)
YearCitationAltmetrics
2020Chen J, Lin F-L, Leung JYK, Tu L, Wang J-H, et al., 'A drug-tunable Flt23k gene therapy for controlled intervention in retinal neovascularization', Angiogenesis, (September) pp. 1-14. ISSN 0969-6970 (2020) [Refereed Article]

DOI: 10.1007/s10456-020-09745-7 [eCite] [Details]

Co-authors: Lin F-L; Chuang Y-F; Hewitt AW; Liu G-S

Tweet

2018Leung JYK, Bennett WR, King AE, Chung RS, 'The impact of metallothionein-II on microglial response to tumor necrosis factor-alpha (TNFα) and downstream effects on neuronal regeneration', Journal of Neuroinflammation, 15, (1) pp. 1-9. ISSN 1742-2094 (2018) [Refereed Article]

DOI: 10.1186/s12974-018-1070-3 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Bennett WR; King AE; Chung RS

Tweet

2012Leung JYK, Bennett WR, Herbert RP, West AK, Lee PR, et al., 'Metallothionein promotes regenerative axonal sprouting of dorsal root ganglion neurons after physical axotomy', Cellular and Molecular Life Sciences, 69, (5) pp. 809-817. ISSN 1420-9071 (2012) [Refereed Article]

DOI: 10.1007/s00018-011-0790-7 [eCite] [Details]

Citations: Scopus - 12Web of Science - 12

Co-authors: Bennett WR; Herbert RP; West AK; Chuah MI; Chung RS

Tweet

2012Ng JMJ, Chen MJ, Leung JYK, Peng ZF, Manikandan J, et al., 'Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro', Journal of Cellular and Molecular Medicine, 16, (4) pp. 789-811. ISSN 1582-4934 (2012) [Refereed Article]

DOI: 10.1111/j.1582-4934.2011.01361.x [eCite] [Details]

Citations: Scopus - 9Web of Science - 7

Co-authors: Ng JMJ; Chuah MI; West AK; Vickers JC; Cheung NS; Chung RS

Tweet

2011Hale DM, Ray S, Leung JY, Holloway AF, Chung RS, et al., 'Olfactory ensheathing cells moderate nuclear factor kappaB translocation in astrocytes ', Molecular and Cellular Neuroscience, 46, (1) pp. 213-221. ISSN 1044-7431 (2011) [Refereed Article]

DOI: 10.1016/j.mcn.2010.09.004 [eCite] [Details]

Citations: Scopus - 9Web of Science - 8

Co-authors: Hale DM; Ray S; Holloway AF; Chung RS; West AK; Chuah MI

Tweet

2011West AK, Leung JYK, Chung RS, 'Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins', Journal of Biological Inorganic Chemistry, 16, (7) pp. 1115-1122. ISSN 0949-8257 (2011) [Refereed Article]

DOI: 10.1007/s00775-011-0817-4 [eCite] [Details]

Citations: Scopus - 18Web of Science - 20

Co-authors: West AK; Chung RS

Tweet

2010Leung YKJ, Pankhurst M, Dunlop SA, Ray S, Dittmann J, et al., 'Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways ', Experimental Neurology: A Journal of Neuroscience Research, 221, (1) pp. 98-106. ISSN 0014-4886 (2010) [Refereed Article]

DOI: 10.1016/j.expneurol.2009.10.006 [eCite] [Details]

Citations: Scopus - 43Web of Science - 45

Co-authors: Pankhurst M; Ray S; Dittmann J; Eaton ED; Chuah MI; West AK; Chung RS

Tweet

2009Chung RS, Leung YK, Butler CW, Chen Y, Eaton ED, et al., 'Metallothionein Treatment Attenuates Microglial Activation and Expression of Neurotoxic Quinolinic Acid Following Traumatic Brain Injury ', Neurotoxicity Research: An International Journal on Processes and Mechanisms in Neurodegeneration, Apoptosis, Neuroprotection and Regeneration, 15, (4) pp. 381-389. ISSN 1029-8428 (2009) [Refereed Article]

DOI: 10.1007/s12640-009-9044-y [eCite] [Details]

Citations: Scopus - 21Web of Science - 20

Co-authors: Chung RS; Butler CW; Eaton ED; Pankhurst MW; West AK

Tweet

2008Chung RS, Penkowa M, Dittmann J, King CE, Bartlett C, et al., 'Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury', Journal of Biological Chemistry, 283, (22) pp. 15349-15358. ISSN 0021-9258 (2008) [Refereed Article]

DOI: 10.1074/jbc.M708446200 [eCite] [Details]

Citations: Scopus - 122Web of Science - 112

Co-authors: Chung RS; Dittmann J; King CE; Walker AK; Fung SJ; Chuah MI; Vickers JC; West AK

Tweet

2008Leung JY, Chapman JA, Harris JA, Hale DM, Chung RS, et al., 'Olfactory ensheathing cells are attracted to, and can endocytose, bacteria', Cellular and Molecular Life Sciences, 65, (17) pp. 2732-2739. ISSN 1420-682X (2008) [Refereed Article]

DOI: 10.1007/s00018-008-8184-1 [eCite] [Details]

Citations: Scopus - 52Web of Science - 48

Co-authors: Chapman JA; Harris JA; Hale DM; Chung RS; West AK; Chuah MI

Tweet

2007Chung RS, Fung SJ, *Leung YK, Walker AK, McCormack GH, et al., 'Metallothionein expression by NG2 glial cells following CNS injury', Cellular and Molecular Life Sciences, 64, (19-20) pp. 2716-2722. ISSN 1420-682X (2007) [Refereed Article]

DOI: 10.1007/s00018-007-7267-8 [eCite] [Details]

Citations: Scopus - 12Web of Science - 12

Co-authors: Chung RS; Fung SJ; Walker AK; McCormack GH; Chuah MI; Vickers JC; West AK

Tweet

Conference Publication

(1 outputs)
YearCitationAltmetrics
2008Leung JY, Chapman JA, Harris JA, Chung RS, West AK, et al., 'Olfactory ensheathing cells are attracted to, and are capable of phagocytosing bacteria', Proceedings of the Australian Neuroscience Society, 27-30 January 2008, Hobart, Tasmania (2008) [Conference Extract]

[eCite] [Details]

Co-authors: Chapman JA; Harris JA; Chung RS; West AK; Chuah MI

Grants & Funding

  • Bill Gole Postdoctoral Research Fellowship from the Motor Neuron Disease Research Australia (three year postdoctoral fellowship to undertake research in the Wicking Centre)
  • Project Grant from the Alzheimer's Australia Dementia Research Fund (1 year project funding on the role of oligodendrocytes in Frontal Temporal Lobar Dementia)
  • Research Enhancement Grant Scheme (REGS) from the University of Tasmania (1 year project funding on the role of oligodendrocytes in Amyotrophic Lateral Sclerosis)

Funding Summary

Number of grants

7

Total funding

$1,526,541

Projects

HDAC6 inhibition to rescue axon degeneration in ALS (2019 - 2022)$997,046
Description
We will test an HDAC6 inhibitor in models of ALS. We will investigate the HDA6 inhibitor activity of novel compounds
Funding
FightMND ($997,046)
Scheme
Grant - Drug Development Grant
Administered By
University of Tasmania
Research Team
King AE; Cook AL; Guven N; Van Den Bosch L; Dickson TC; Blizzard C; Vickers JC; Smith JA; Alty JE; Leung JY; Perry SE
Period
2019 - 2022
Towards Axon Protection in ALS (2018)$98,470
Description
Nerve cells communicate with each other and their targets, such as muscle, via long processes called axons. In motor neuron disease these nerve cell processes degenerate and are lost, resulting in a loss of movement. Several mechanisms or axon degeneration have been recently identified, but we dont know which of these mechanisms is involved in motor neuron disease. In this project, we will use two models to determine which mechanisms of axon degeneration are involved in nerve process loss in motor neuron disease. This will allow us to determine which molecules to target for therapeutic intervention.
Funding
Motor Neurone Disease Research Institute of Australia Inc ($98,470)
Scheme
Grant-In-Aid
Administered By
University of Tasmania
Research Team
King AE; Perry SE; Leung JY
Year
2018
Targeting dysregulated miRNAs and transforming growth factor-B-activated kinase 1 (TAK1) to stop the growth of leaky blood vessels in diabetic eyes (2018)$24,540
Description
Vision loss from diabetic retinopathy is a global clinical and public health concern, significantlyimpacting the quality of life of patients. Whilst therapies such as anti-VEGF (antibody-basedmedications) have been a breakthrough in the management of vision-threatening stages ofdiabetic retinopathy, significant irreversible retinal damage can already have occurred by thisstage. Here we seek support to develop the novel therapeutic strategies targeting critical generegulator (microRNAs, short non-coding RNAs), that combat the earliest pathological cascadesthat predispose to blindness in those with diabetes. Success in this project will provide theimpetus to pursue novel treatments that target the earliest pathological steps in the developmentof diabetic retinopathy. This has important implications for preventing vision loss in asubstantial number of people at risk from diabetic retinopathy.
Funding
University of Tasmania ($24,540)
Scheme
Grant- Research Enhancement Program
Administered By
University of Tasmania
Research Team
Liu G; Bui B; Leung JY; Dusting G
Year
2018
Identifying the role of oligodendrocytes in disease onset and the progression in Amyotrophic Lateral Sclerosis (2017)$99,923
Description
Neurons have been the main focus of research and the target of therapeutic development in Amyotrophic Lateral Sclerosis (ALS). Previous studies have display evidence showing the potential involvement of other non-neuronal cells in the disease progression including astrocytes, microglia and oligodendrocytes. Although loss of myelin and oligodendrocyte degeneration has been identified, it has been mostly regarded as a secondary event occurring as a response to the degeneration of axons. Our recent studies have shown evidence supporting the potential active role ofTDP43 (TAR-DNA-binding protein 43) in oligodendrocytes development in vitro. These results suggested that alteration of TDP43 expression could induced oligodendrocytes pathology in ALS and is possible to have an active contribution to disease progress in ALS as well as the onset of the disease.
Funding
Motor Neurone Disease Research Institute of Australia Inc ($99,923)
Scheme
Grant-In-Aid
Administered By
University of Tasmania
Research Team
Leung JY; King AE
Year
2017
Investigating the role of oligodendrocytes in frontotemporal lobar dementia (FTLD) (2015)$50,000
Description
Current research on frontotemporal-lobar dementia (FTLD) is focused on the detrimental effect of the pathological proteins in neurons. However, in FTLD, protein aggregates are also found in oligodendrocytes, which are responsible for myelinating and supporting axons. FTLD has a strong genetic and pathological links with Amyotrophic Lateral Sclerosis (ALS), the most common form of motor neuron disease. In ALS there is now substantial evidences suggesting that oligodendrocyte degeneration is involved in disease pathogenesis potentially as a primary pathologic mechanism. Both FTLD and ALS share the common pathologic protein, TDP-43, which is found to aggregate in oligodendrocytes, hence it is feasible to suggest a role for oligodendrocyte dysfunction in FTLD. Studies in ALS tissue and mouse models have suggested that defects in the differentiation and maturation of oligodendrocytes as well as their ability to myelinate axons may contribute to the disease. This proposed study aims to establish the role of oligodendrocyte dyfunction in FTLD with a focus on determining the potential role of TDP-43 in the differentiation and remyelination process of oligodendrocytes. This will allow us to have a better understanding in the pathogenesis of FTLD as well as identifying new therapeutic targets for treatments.
Funding
Dementia Australia Research Foundation Ltd ($50,000)
Scheme
Grant-Dementia Grants Program
Administered By
University of Tasmania
Research Team
Leung JY; King AE
Year
2015
Investigating the role of oligodendrocytes in Amyotrophic Lateral Sclerosis (ALS) (2015)$16,562
Funding
University of Tasmania ($16,562)
Scheme
Grant-Research Enhancement (REGS)
Administered By
University of Tasmania
Research Team
Leung JY
Year
2015
Investigating the role of oligodendrocytes in Amyotrophic Lateral Sclerosis (2014 - 2016)$240,000
Description
Amyotrophic Lateral Sclerosis (ALS) is characterized by the progressive loss of motor neurons in brain and spinal cord. The axons (longest processes of neurons) of the motor neurons are mostly wrapped by the oligodendrocytes that produce myelin, an insulating layer that allows rapid conduction of the neuronal signal. The oligodendrocytes were also recently been identified to play an import role in providing metabolic support to these axons. Recent evidences in ALS research have suggested that oligodendrocytes might have an active role in both disease onset and disease progression in ALS. This study will focus on understanding the role of oligodendrocytes in ALS and allow us to uncover specific mechanisms in the involvement of oligodendrocytes in ALS. The results collected from this study will contribute to a greater understanding of disease processes in ALS, as well as establishing new therapeutic targets in ALS treatments.
Funding
Motor Neurone Disease Research Institute of Australia Inc ($240,000)
Scheme
Fellowship-Bill Gole MND Research
Administered By
University of Tasmania
Research Team
Leung JY
Period
2014 - 2016

Research Supervision

Currently supervising one honours student due to complete end of 2015, the honours project is working on the role of oligodendrocytes in neurodegenerative diseases, which involves cell cultures and live imaging techniques.

Current

3

Current

DegreeTitleCommenced
PhDOligodendrocyte Dysfunction in Dementia and Alzheimers Disease2016
PhDInvestigating Mechanisms of Axon Degeneration and Protection in Neurological Disease2017
PhDCRISPR-RNA Editing of VEGF to Block Ocular Angiogenesis2021