Profiles

Jane Alty

UTAS Home A/Professor Jane Alty

Jane Alty

Associate Professor of Neurology, UTAS Co-Director of the ISLAND Clinic, UTAS Staff Specialist in Neurology and Stroke (Royal Hobart Hospital)
Wicking Dementia Research and Education Centre & School of Medicine

Medical Sciences 1, Level 4 , Hobart CBD Campuses

+61 (0)4 7373 2562 (phone)

jane.alty@utas.edu.au

Associate Professor Jane Alty is a Neurology clinician, researcher and educator. Her work addresses University strategies to build a healthier Tasmania and has national and international impact. Her goal is to transform the health of adults in Tasmania and globally - through research to detect the critical earliest stages of degenerative brain disorders and through teaching to improve health literacy and clinical care.

Jane is an early career researcher at the Wicking Dementia Research and Education Centre and the School of Medicine, and a Neurology Staff Specialist at the Royal Hobart Hospital. Her inter-disciplinary research focuses on applying Artificial-Intelligence (AI) methods, and other computer science approaches,  to solve medical problems. In particular, her research aims to  develop digital biomarkers that will help with early detection, accurate monitoring and prevention of Parkinson’s disease and Alzheimer's disease – the two most common neurodegenerative disorders. She has a particular interest in developing population-level low-cost tests that help detect the prodromal phase of Parkinson’s, (including REM sleep behaviour disorder) and the pre-clinical phase of Alzheimer’s – as these phases offer the best chance for interventions aimed at stopping further progression.

Biography

Jane is from the UK and qualified in Medicine from the University of Cambridge, UK. She completed 4 years of medical training in Cambridge, Manchester, London and Leeds and, after passing her professional postgraduate physician exams (MRCP), she undertook 5 years of specialist neurology training in Leeds and York. She completed a 6-month Movement Disorders Fellowship at Monash Medical Centre in 2007 and also took time out of her clinical neurology training to complete a 2-year period of AI-neuroscience research in Parkinson’s at the University of York; she was subsequently conferred a Doctorate of Medicine for her thesis on “Objective evaluation of Parkinson’s disease bradykinesia”.  Her research made significant contributions to the commercialization of 3 medical devices (that have since been used in phase 3 clinical trials and also in clinical monitoring) and Jane was appointed as Medical Advisor the subsequent spin out company, ClearSky Medical Diagnostics.

She was appointed Consultant Neurologist at the Leeds Teaching Hospital NHS Trust in 2013 and led specialist clinics in complex Parkinson’s disease, tremor, functional movement disorders and dystonia, including administering botulinum toxin injections and referral for advanced therapies such as deep brain stimulation surgery. She was local PI for several clinical trials in Parkinson’s disease and related disorders. In her clinical roles., Jane won a number of prizes for quality improvement projects, Clinical Excellence Awards, innovation for new devices and also national patient safety awards.

In 2019, Jane was actively recruited to UTAS as an academic neurologist. She is now the Co-Director of the UTAS ISLAND Cognitive Clinic, a one-stop interdisciplinary research cognitive clinic that provides a State-wide diagnostic service for adults with cognitive symptoms in Tasmania. She also runs a specialist Parkinson’s disease and movement disorders clinic at the Royal Hobart Hospital. She is a member of the Steering Committee for The ISLAND Project - the largest dementia prevention study in the world with >14,000 participants. In 2020, she was awarded a 5-year NHMRC Idea grant (2021-25) to develop new digital biomarkers of pre-clinical Alzheimer’s disease and now leads the TAS Test project, working with an interdisciplinary group of researchers in neuroscience, computer science and psychology. She was also awarded a 3 year Major Project Grant by the Royal Hobart Hospital Research Foundation (2022-24) and leads a team of researchers and clinicians to develop a mobile phone TapTalkTest for quick cognitive screening in clinical and research settings.

Career summary

Qualifications

Degree

University

Country

Date Awarded

FRACP

Royal Australasian College of Physicians

Australia

2021

FRCP

Royal College of Physicians London

UK

2017

MD

University of York

UK

2014

MRCP

Royal College of Physicians London

UK

2003

MA (Cantab.)

University of Cambridge

UK

2001

MB BChir (Distinction)

University of Cambridge

UK

1999

BA (Hons)

University of Cambridge

UK

1997

Memberships

Professional practice

Royal College of Physicians, London, UK

Royal Australasian College of Physicians

Australian and New Zealand Association of Neurologists

Association of British Neurologists

Australasian Cognitive Neurology Association

Functional Neurological Disorders Society

Australian Dementia Network

Administrative expertise

Elected secretary of the Australasian Cognitive Neurology Association

Elected academic staff member on the University of Tasmania Academic Senate

Teaching

Teaching expertise

Associate Professor Jane Alty is a passionate teacher with 15 years of clinical teaching experience, underpinned by professional training in learning theory. She teaches clinical skills and Neurology to medical students, through bedside and small-group formats. She has also created new teaching materials on clinically relevant neurobiology, and the diagnostic process of dementia, for the Masters of Dementia course (CAD 602). Jane previously designed the curriculum, created the content and led the delivery of a UK-wide ‘Leeds dystonia’ neurology course for clinicians that ran 5 times, and her teaching was consistently rated as ‘excellent’ or ‘very good’. Jane also has experience of teaching a range of students in Europe, Africa and Australia where she often uses case-based learning theory to navigate the challenges of language and cultural differences. For example, in 2018, she  was selected by the Royal College of Physicians London as one of only two UK Neurologists to provide a one-week postgraduate Neurology course in Rwanda for doctors from East Africa.

View more on AssocProf Jane Alty in WARP

Expertise

Parkinson’s disease.  Alzheimer’s disease.  Biomarkers.  Early detection, Artificial Intelligence, motor-cognitive., computer vision

Current projects

Jane’s research interests focus on developing simple accessible tests that can be accessed by people around the world to detect the earliest stages of Alzheimer’s disease and Parkinson’s disease. She brings together her clinical training in Neurology with her research interests in computer science and bioengineering to develop low-cost population-level tests. She is particularly interested in using home computers and smartphones as these are so easy to access for most people around the world. Her research also focuses on developing precise technologies that can track the progression of these conditions, as well as measure motor features related to tremor, dystonia, speech, cognitive impairment and gait.

Jane is currently leading 4 research projects based at UTAS and also has several international collaborations with other research groups:

  1. TAS Test Project

    Did you know that hand movement patterns subtly change in the earliest stages of dementia, 10-20 years before any memory or thinking symptoms? This means that if we can accurately measure hand movement changes, we may be able to predict who is at high risk of dementia much earlier than current tests. This is the concept behind TAS Test - a new type of computer test that is being developed by researchers at the University of Tasmania. Jane has brought together a large team of researchers form the Wicking Dementia Centre, School of ICT and psychology to develop a unique measure of dementia risk that is designed to be completed at home. So far, we have assessed more than 3,000 people’s hand movements and have shown that certain features of movement are predictive of dementia risk.

  2. TapTalkTest Project

    Alzheimer’s disease (AD) causes 70% of all dementia. It starts damaging the brain >10 years before memory problems begin. To reduce dementia incidence, we must detect AD earlier. With 200 patients and 3,000 research participants, we will develop a new smartphone test that detects early AD through hand movement and speech analysis. Jane is leading a team that brings together software development with new rapid motor-cognitive assessments. Our proposed test will non-invasively detect AD pathology, enabling people with early-stage AD to be proactive before their brain is irreparably damaged - to commence intense risk modification (that can slow/prevent 40% dementia) and to enter drug trials. It will also facilitate earlier diagnosis of dementia, which reduces hospital admissions and costs. Using our national and international networks for upscaling, the outcomes of this project will have global impact to transform dementia prevention. The new test will be compared to current pen and paper cognitive tests, and to blood biomarkers, in hospital and outpatient settings.

  3. ISLAND Clinic

    Jane is the Co-Director of the ISLAND Clinic and lead for research. The ISLAND Clinic is the diagnostic and research Tasmanian Dementia and Cognition Clinic and operates under the Wicking Dementia Research and Education Centre programs. It is one of a suite of specialist clinics that are affiliated with the Australian Dementia Network (ADNet), an initiative funded by the National Health and Medical Research Council that seeks to build a national Clinical Quality Registry, harmonise operations and data collection through cognitive clinics, and build capacity for clinical trials in dementia nationally.

    The ISLAND Clinic’s primary aim is to provide timely and expert interdisciplinary assessment, diagnosis, support, referral and information for Tasmanians with cognitive symptoms referred by their GP and to build up a research database to enable better understanding of cognitive impairment and dementia. To achieve this, The ISLAND Clinic uses a person-centred process involving an interdisciplinary team of clinicians including a neurologist, geriatricians, neuropsychologist, GP, neuro-radiologist, nursing and allied health professionals. The ISLAND Clinic offers a ‘one-stop’ bulk-billed diagnostic clinic with all assessments and diagnostic discussion on one day (except for the MRI brain scan that will typically be arranged about a week before clinic).

    All clients will be requested to sign a consent form to enable their medical information to be stored securely on the Wicking database – for the purposes of ongoing clinical care and research. Participants are also invited to provide blood samples and undertake additional research tests to help develop new biomarkers of dementia risk. Our participation in ADNeT requires a minimum dataset of anonymised data will be collected for this purpose and passed onto the national study coordinators.

  4. REM Sleep Behaviour Disorder

REM sleep behaviour disorder (RBD) is associated with significantly increased risk of dementia and other neurodegenerative diseases in the future. It is characterised by people kicking their arms and legs out whilst dreaming. The progression of this disorder in an older adult population is not fully understood and it is also unclear whether changes in thinking, movement and sense of smell may increase the risk of people with RBD developing a neurodegenerative disorder. This research project will identify the prevalence of RBD in older Tasmanians, and then explore different aspects of their brain function that may be associated with increased risk of dementia.  Identifying RBD early will provide opportunities to enrol people in risk reduction research and drug trials to try and prevent progression. This project aims to identify the prevalence of RBD, sleep rhythm regulation, olfactory function and associated cognitive and motor profiles in older participants within the Tasmanian community, develop a scalable online screening test to detect RBD at an early stage, before significant cognitive symptoms and track the cognitive, motor and olfactory functions of people with RBD over time to better understand what features of RBD put people at higher risk of dementia.

Fields of Research

  • Neurology and neuromuscular diseases (320905)
  • Central nervous system (320903)
  • Geriatrics and gerontology (320210)
  • Computer vision (460304)
  • Preventative health care (420605)
  • Cognitive neuroscience (520203)
  • Health services and systems (420399)
  • Health management (420309)
  • Applications in health (460102)
  • Health promotion (420603)
  • Radiology and organ imaging (320222)
  • Aged health care (420301)
  • Digital health (420302)
  • Neurosciences (320999)
  • Implementation science and evaluation (420312)
  • Cardiology (incl. cardiovascular diseases) (320101)
  • Epidemiology (420299)
  • Artificial life and complex adaptive systems (460201)
  • Diagnostic radiography (320206)
  • Health informatics and information systems (420308)
  • Evolutionary computation (460203)
  • Clinical sciences (320299)
  • Peripheral nervous system (320906)
  • Oral and maxillofacial surgery (320305)
  • People with disability (420318)
  • Sensory systems (320907)
  • Medical biotechnology (320699)
  • Primary health care (420319)
  • Behavioural neuroscience (520202)
  • Artificial intelligence (460299)
  • Cognition (520401)
  • Speech recognition (460212)
  • Exercise physiology (420702)
  • Physiotherapy (420106)
  • Human-computer interaction (460806)
  • Clinical neuropsychology (520301)
  • Sensor technology (incl. chemical aspects) (340108)
  • Analytical biochemistry (310101)
  • Behavioural epidemiology (420201)
  • Health surveillance (420310)
  • Virtual and mixed reality (460708)
  • Epidemiological modelling (420205)
  • Satisfiability and optimisation (460210)
  • Motor control (420703)
  • Intensive care (320212)
  • Deep learning (461103)
  • Computational neuroscience (incl. mathematical neuroscience and theoretical neuroscience) (320904)

Research Objectives

  • Diagnosis of human diseases and conditions (200101)
  • Clinical health (200199)
  • Treatment of human diseases and conditions (200105)
  • Preventive medicine (200412)
  • Artificial intelligence (220403)
  • Health related to ageing (200502)
  • Health education and promotion (200203)
  • Mental health (200409)
  • Prevention of human diseases and conditions (200104)
  • Behaviour and health (200401)
  • Efficacy of medications (200102)
  • Evaluation of health outcomes (200202)
  • Evaluation of health and support services (200299)
  • Allied health therapies (excl. mental health services) (200301)
  • Human-computer interaction (220407)
  • Health policy evaluation (200205)
  • Migrant health (200505)
  • Outpatient care (200308)
  • Languages and linguistics (130202)
  • Palliative care (200309)
  • Expanding knowledge in the health sciences (280112)
  • Telehealth (200208)
  • Health related to specific ethnic groups (200503)
  • Injury prevention and control (200408)
  • Public health (excl. specific population health) (200499)
  • Exercise (130601)
  • Other health (209999)
  • Primary care (200310)
  • Health inequalities (200204)
  • Expanding knowledge in psychology (280121)
  • Health system performance (incl. effectiveness of programs) (200206)
  • Expanding knowledge in the information and computing sciences (280115)
  • Information systems, technologies and services (220499)

Publications

Jane has published throughout her career, despite clinical commitments and career disruptions. She is classed as an Early Career Researcher with < 5 FTE years since completing her MD (allowing for career disruptions). She has published 73 peer-reviewed journal papers (46 in the last 5 years; 47% as first/senior author) with more than 1,200 citations and her Google Scholar h index is 19. Jane is also lead author on two medical textbooks and has also published a documentary ‘Tremulous Hands’ on tremor and Parkinson’s (available on YouTube), two book chapter and multiple conference abstracts.

For a full list of Associate Professor Jane Alty’s publications, please see: ORCID iD: https://orcid.org/0000-0002-5456-8676.

Total publications

95

Highlighted publications

(4 outputs)
YearTypeCitationAltmetrics
2020Journal ArticleAlty J, Farrow M, Lawler K, 'Exercise and dementia prevention', Practical Neurology, 20, (3) pp. 234-240. ISSN 1474-7758 (2020) [Refereed Article]

DOI: 10.1136/practneurol-2019-002335 [eCite] [Details]

Citations: Scopus - 27Web of Science - 23

Co-authors: Farrow M; Lawler K

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2020Journal ArticleWilliams S, Zhao Z, Hafeez A, Wong DC, Relton SD, et al., 'The discerning eye of computer vision: can it measure Parkinson's finger tap bradykinesia?', Journal of The Neurological Sciences, 416 Article 117003. ISSN 0022-510X (2020) [Refereed Article]

DOI: 10.1016/j.jns.2020.117003 [eCite] [Details]

Citations: Scopus - 23Web of Science - 22

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2017Journal ArticleAlty J, Cosgrove J, Thorpe D, Kempster P, 'How to use pen and paper tasks to aid tremor diagnosis in the clinic', Practical Neurology, 17, (6) pp. 456-463. ISSN 1474-7758 (2017) [Refereed Article]

DOI: 10.1136/practneurol-2017-001719 [eCite] [Details]

Citations: Scopus - 23

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2013BookAlty J, Hoey E, 'Practical Ultrasound: An Illustrated Guide', CRC Press, United Kingdom, pp. 295. ISBN 9781444168297 (2013) [Authored Other Book]

[eCite] [Details]

Journal Article

(65 outputs)
YearCitationAltmetrics
2023Begley R, Farrell L, Alty J, Lyttle N, Curran D, et al., 'Clinicians' implicit and explicit attitudes about the legitimacy of functional neurological disorders correlate with referral decisions', British Journal of Health Psychology ISSN 2044-8287 (2023) [Refereed Article]

[eCite] [Details]

2023Bramich S, Verdi K, Salmon K, Noyce A, Alty J, 'REM sleep behaviour disorder: the importance of early identification', British Journal of General Practice ISSN 0960-1643 (In Press) [Refereed Article]

[eCite] [Details]

Co-authors: Bramich S; Salmon K

2022Alty JE, Bai Q, Li R, Lawler K, St George RJ, et al., 'The TAS Test project: a prospective longitudinal validation of new online motor-cognitive tests to detect preclinical Alzheimer's disease and estimate 5-year risks of cognitive decline and dementia', BMC Neurology, 22 Article 266. ISSN 1471-2377 (2022) [Refereed Article]

DOI: 10.1186/s12883-022-02772-5 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Bai Q; Li R; Lawler K; St George RJ; Hill E; Bindoff A; Garg S; Wang X; Huang G; Zhang K; Rudd KD; Bartlett L; Goldberg LR; Collins JM; Hinder MR; King AE; Vickers JC

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2022Alty JE, Bindoff A, Stuart K, Hill E, Collins J, et al., 'Sex-specific protective effects of cognitive reserve on age-related cognitive decline: A 5-Year prospective cohort study', Neurology ISSN 0028-3878 (2022) [Refereed Article]

DOI: 10.1212/WNL.0000000000201369 [eCite] [Details]

Co-authors: Bindoff A; Stuart K; Hill E; Collins J; King A; Vickers J

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2022Bartlett L, Doherty K, Farrow M, Kim S, Hill E, et al., 'Island Study Linking Aging and Neurodegenerative Disease (ISLAND) targeting dementia risk reduction: protocol for a prospective web-based cohort study', JMIR Research Protocols, 11, (3) Article e34688. ISSN 1929-0748 (2022) [Refereed Article]

DOI: 10.2196/34688 [eCite] [Details]

Citations: Scopus - 1Web of Science - 3

Co-authors: Bartlett L; Doherty K; Farrow M; Kim S; Hill E; King A; Eccleston C; Kitsos A; Bindoff A; Vickers JC

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2022Bramich S, King A, Kuruvilla M, Naismith SL, Noyce A, et al., 'Isolated REM sleep behaviour disorder: current diagnostic procedures and emerging new technologies', Journal of Neurology, 269, (9) pp. 4684-4695. ISSN 0340-5354 (2022) [Refereed Article]

DOI: 10.1007/s00415-022-11213-9 [eCite] [Details]

Co-authors: Bramich S; King A; Kuruvilla M; Naismith SL

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2022Costa S, St George RJ, McDonald JS, Wang X, Alty J, 'Diagnostic accuracy of the overlapping infinity loops, wire cube, and clock drawing tests in subjective cognitive decline, mild cognitive impairment and dementia', Geriatrics, 7, (4) Article 72. ISSN 2308-3417 (2022) [Refereed Article]

DOI: 10.3390/geriatrics7040072 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: St George RJ; McDonald JS; Wang X

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2022Day JO, Smith S, Noyce AJ, Alty J, Jeffery A, et al., 'Challenges of incorporating digital health technology outcomes in a clinical trial: experiences from PD STAT', Journal of Parkinson's Disease, 12, (5) pp. 1605-1609. ISSN 1877-7171 (2022) [Refereed Article]

DOI: 10.3233/JPD-223162 [eCite] [Details]

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2022Huang G, Tran SN, Bai Q, Alty J, 'Real-time automated detection of older adults' hand gestures in home and clinical settings', Neural Computing and Applications pp. 1-14. ISSN 0941-0643 (2022) [Refereed Article]

DOI: 10.1007/s00521-022-08090-8 [eCite] [Details]

Co-authors: Huang G; Tran SN; Bai Q

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2022Khan S, Sowemimo N, Alty J, Cosgrove J, 'Increased knowledge of adult-onset dystonia amongst medical students via brief video education: a systematic review and cohort study', Geriatrics, 7, (3) Article 58. ISSN 2308-3417 (2022) [Refereed Article]

DOI: 10.3390/geriatrics7030058 [eCite] [Details]

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2022Khan S, Vital EM, Patil A, Currie S, Backouse O, et al., 'Systemic lupus erythematosus-induced intracranial hypertension: rare but important', Practical Neurology, 22 pp. 425-426. ISSN 1474-7758 (2022) [Refereed Article]

DOI: 10.1136/practneurol-2022-003424 [eCite] [Details]

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2022Li R, St George RJ, Wang X, Lawler K, Hill E, et al., 'Moving towards intelligent telemedicine: Computer vision measurement of human movement', Computers in Biology and Medicine, 147 Article 105776. ISSN 0010-4825 (2022) [Refereed Article]

DOI: 10.1016/j.compbiomed.2022.105776 [eCite] [Details]

Citations: Web of Science - 1

Co-authors: Li R; St George RJ; Wang X; Lawler K; Hill E; Garg S; Bai Q

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2022Li R, Wang X, Lawler K, Garg S, Bai Q, et al., 'Applications of artificial intelligence to aid early detection of dementia: a scoping review on current capabilities and future directions', Journal of Biomedical Informatics, 127 Article 104030. ISSN 1532-0464 (2022) [Refereed Article]

DOI: 10.1016/j.jbi.2022.104030 [eCite] [Details]

Citations: Scopus - 7Web of Science - 5

Co-authors: Li R; Wang X; Lawler K; Garg S; Bai Q

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2022Merl H, Doherty KV, Alty J, Salmon K, 'Truth, hope and the disclosure of a dementia diagnosis: a scoping review of the ethical considerations from the perspective of the person, carer and clinician', Dementia, 21, (3) pp. 1050-1068. ISSN 1471-3012 (2022) [Refereed Article]

DOI: 10.1177/14713012211067882 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Merl H; Doherty KV; Salmon K

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2022Newby R, Muhamed S, Alty J, Cosgrove J, Jamieson S, et al., 'Geste antagoniste effects on motor performance in dystonia a kinematic study', Movement Disorders Clinical Practice, 9, (6) pp. 759-764. ISSN 0885-3185 (2022) [Refereed Article]

DOI: 10.1002/mdc3.13505 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2022Wang Xinyi, St George RJ, Bai Q, Tran S, Alty J, 'New horizons in late-onset essential tremor: a pre-cognitive biomarker of dementia?', Age and Ageing, 51, (7) pp. 1-8. ISSN 0002-0729 (2022) [Refereed Article]

DOI: 10.1093/ageing/afac135 [eCite] [Details]

Co-authors: Wang Xinyi; St George RJ; Bai Q; Tran S

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2022Wang Xinyi, St George RJ, Bai Q, Tran SN, Alty J, 'Differences in clinical manifestations of late onset, compared to earlier onset essential tremor: a scoping review', Journal of the neurological sciences, 440 pp. 1-5. ISSN 0022-510X (2022) [Refereed Article]

DOI: 10.1016/j.jns.2022.120336 [eCite] [Details]

Co-authors: Wang Xinyi; St George RJ; Bai Q; Tran SN

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2022Williams S, Southall C, Haley S, Dhafari TB, Kemp S, et al., 'To the emergency room and back again: circular healthcare pathways for acute functional neurological disorders', Journal of the Neurological Sciences, 437 Article 120251. ISSN 0022-510X (2022) [Refereed Article]

DOI: 10.1016/j.jns.2022.120251 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2021Alissa M, Lones MA, Cosgrove J, Alty JE, Jamieson S, et al., 'Parkinson's disease diagnosis using convolutional neural networks and figure-copying tasks', Neural Computing and Applications ISSN 0941-0643 (2021) [Refereed Article]

DOI: 10.1007/s00521-021-06469-7 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

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2021Bindoff AD, Summers MJ, Hill E, Alty J, Vickers JC, 'Studying at university in later life slows cognitive decline: A long-term prospective study', Alzheimer's & Dementia: Translational Research & Clinical Interventions pp. 1-10. ISSN 2352-8737 (2021) [Refereed Article]

DOI: 10.1002/trc2.12207 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Bindoff AD; Hill E; Vickers JC

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2021Collins JM, Hill E, Bindoff A, King AE, Alty J, et al., 'Association Between Components of Cognitive Reserve and Serum BDNF in Healthy Older Adults', Frontiers in Aging Neuroscience, 13 pp. 1-9. ISSN 1663-4365 (2021) [Refereed Article]

DOI: 10.3389/fnagi.2021.725914 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Collins JM; Hill E; Bindoff A; King AE; Summers MJ; Vickers JC

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2021Cosgrone J, Hinder MR, St George RJ, Picardi C, Smith SL, et al., 'Significant cognitive decline in Parkinson's disease exacerbates the reliance on visual feedback during upper limb reaches', Neuropsychologia, 157 Article 107885. ISSN 0028-3932 (2021) [Refereed Article]

DOI: 10.1016/j.neuropsychologia.2021.107885 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Hinder MR; St George RJ

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2021Dosanjh M, Alty J, Martin C, Latchford G, Graham CD, 'What is it like to live with a functional movement disorder? An interpretative phenomenological analysis of illness experiences from symptom onset to post-diagnosis', British Journal of Health Psychology, 26, (2) pp. 325-342. ISSN 1359-107X (2021) [Refereed Article]

DOI: 10.1111/bjhp.12478 [eCite] [Details]

Citations: Scopus - 5Web of Science - 6

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2021Hill E, Alty J, Bartlett L, Goldberg L, Park M, et al., 'Automated analysis of propositional idea density in older adults', Cortex, 145 pp. 264-272. ISSN 0010-9452 (2021) [Refereed Article]

DOI: 10.1016/j.cortex.2021.09.018 [eCite] [Details]

Citations: Scopus - 1

Co-authors: Hill E; Bartlett L; Goldberg L; Park M; Yeom S; Vickers J

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2021Morgan J, Bindoff A, Doherty K, Vickers J, Alty J, 'Are tomorrow's doctors prepared to prevent dementia? A cross-sectional study of Tasmanian medical students' knowledge of dementia risk factors', Journal of Clinical Neuroscience ISSN 0967-5868 (2021) [Refereed Article]

DOI: 10.1016/j.jocn.2021.11.005 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Morgan J; Bindoff A; Doherty K; Vickers J

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2021Tucker H, Osei-Poku F, Ashton D, Lally R, Jesuthasan A, et al., 'Management of secondary poor response to botulinum toxin in cervical dystonia: a multicenter audit', Movement Disorders Clinical Practice, 8, (4) pp. 541-545. ISSN 2330-1619 (2021) [Refereed Article]

DOI: 10.1002/mdc3.13181 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2021Varma P, Narayan L, Alty J, Painter V, Padmakumar C, 'An innovative personalised management program for older adults with Parkinson's disease: new concepts and future directions', Journal of Personalized Medicine, 11, (1) Article 43. ISSN 2075-4426 (2021) [Refereed Article]

DOI: 10.3390/jpm11010043 [eCite] [Details]

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2021Wang X, Garg S, Tran SN, Bai Q, Alty J, 'Hand tremor detection in videos with cluttered background using neural network based approaches', Health Information Science and Systems, 9, (1) pp. 1-14. ISSN 2047-2501 (2021) [Refereed Article]

DOI: 10.1007/s13755-021-00159-3 [eCite] [Details]

Citations: Scopus - 4Web of Science - 5

Co-authors: Wang X; Garg S; Tran SN; Bai Q

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2021Williams S, Fang H, Relton SD, Wong DC, Alam T, et al., 'Accuracy of smartphone video for contactless measurement of hand tremor frequency', Movement Disorders Clinical Practice, 8, (1) pp. 69-75. ISSN 2330-1619 (2021) [Refereed Article]

DOI: 10.1002/mdc3.13119 [eCite] [Details]

Citations: Scopus - 9Web of Science - 10

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2020Alty J, Farrow M, Lawler K, 'Exercise and dementia prevention', Practical Neurology, 20, (3) pp. 234-240. ISSN 1474-7758 (2020) [Refereed Article]

DOI: 10.1136/practneurol-2019-002335 [eCite] [Details]

Citations: Scopus - 27Web of Science - 23

Co-authors: Farrow M; Lawler K

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2020Britton D, Alty JE, Mannion CJ, 'Oromandibular dystonia: a diagnosis not to miss', British Journal of Oral and Maxillofacial Surgery, 58, (5) pp. 520-524. ISSN 0266-4356 (2020) [Refereed Article]

DOI: 10.1016/j.bjoms.2020.02.018 [eCite] [Details]

Citations: Scopus - 8Web of Science - 5

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2020Corrado J, Jackson O, Baxandall D, Robson J, Duggan-Carter P, et al., 'Get Parkinson's medications on time: the Leeds QI project', Age and Ageing, 49, (5) pp. 865-872. ISSN 0002-0729 (2020) [Refereed Article]

DOI: 10.1093/ageing/afaa142 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2020Williams S, Fang H, Relton SD, Graham CD, Alty JE, 'Seeing the unseen: could Eulerian video magnification aid clinician detection of subclinical Parkinson's tremor?', Journal of Clinical Neuroscience, 81 pp. 101-104. ISSN 0967-5868 (2020) [Refereed Article]

DOI: 10.1016/j.jocn.2020.09.046 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2020Williams S, Relton SD, Fang H, Alty J, Qahwaji R, et al., 'Supervised classification of bradykinesia in Parkinson's disease from smartphone videos', Artificial Intelligence in Medicine, 110 Article 101966. ISSN 0933-3657 (2020) [Refereed Article]

DOI: 10.1016/j.artmed.2020.101966 [eCite] [Details]

Citations: Scopus - 12Web of Science - 8

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2020Williams S, Zhao Z, Hafeez A, Wong DC, Relton SD, et al., 'The discerning eye of computer vision: can it measure Parkinson's finger tap bradykinesia?', Journal of The Neurological Sciences, 416 Article 117003. ISSN 0022-510X (2020) [Refereed Article]

DOI: 10.1016/j.jns.2020.117003 [eCite] [Details]

Citations: Scopus - 23Web of Science - 22

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2019Khan S, Sivakumar G, Currie S, Alty J, 'Multiple system atrophy mimicked by multi-organ pathology', Practical Neurology ISSN 1474-7758 (2019) [Contribution to Refereed Journal]

DOI: 10.1136/practneurol-2019-002233 [eCite] [Details]

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2019Nagao K, Ding C, Ganga G, Alty JE, Clissold BG, et al., 'Inferring the long duration response to levodopa in Parkinson's disease', Parkinsonism and Related Disorders, 60 pp. 133-137. ISSN 1353-8020 (2019) [Refereed Article]

DOI: 10.1016/j.parkreldis.2018.09.002 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

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2019Smith N, Kimberger K, Parrish C, Currie S, Butterworth S, et al., 'Multiple plasmacytoma with multiple neurological presentations: A difficult case', Practical Neurology, 19, (6) pp. 511-517. ISSN 1474-7758 (2019) [Contribution to Refereed Journal]

DOI: 10.1136/practneurol-2019-002205 [eCite] [Details]

Citations: Web of Science - 3

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2019Thorpe DE, Alty JE, Kempster PA, 'Health at the writing desk of John Ruskin: a study of handwriting and illness', Medical Humanities, 46, (1) pp. 31-45. ISSN 1468-215X (2019) [Refereed Article]

DOI: 10.1136/medhum-2018-011600 [eCite] [Details]

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2019Williams S, Shepherd S, Fang H, Alty J, O'Gorman P, et al., 'Computer vision of smartphone video has potential to detect functional tremor', Journal of the Neurological Sciences, 401 pp. 27-28. ISSN 0022-510X (2019) [Letter or Note in Journal]

DOI: 10.1016/j.jns.2019.04.016 [eCite] [Details]

Citations: Scopus - 4Web of Science - 3

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2018Cosgrove J, Alty JE, 'Cognitive deficits in Parkinson's disease: current perspectives', Journal of Parkinsonism and Restless Legs Syndrome, 8 pp. 1-11. ISSN 1927-7725 (2018) [Refereed Article]

DOI: 10.2147/JPRLS.S125064 [eCite] [Details]

Citations: Web of Science - 1

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2018Gao C, Smith S, Lones M, Jamieson S, Alty J, et al., 'Objective assessment of bradykinesia in Parkinson's disease using evolutionary algorithms: Clinical validation', Translational Neurodegeneration, 7, (18) ISSN 2047-9158 (2018) [Refereed Article]

DOI: 10.1186/s40035-018-0124-x [eCite] [Details]

Citations: Scopus - 27Web of Science - 26

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2018Williams S, Fang H, Alty J, Qahwaji R, Patel P, et al., 'A smartphone camera reveals an 'invisible' Parkinsonian tremor: A potential pre-motor biomarker?', Journal of Neurology, 265, (12) pp. 3017-3018. ISSN 0340-5354 (2018) [Letter or Note in Journal]

DOI: 10.1007/s00415-018-9060-z [eCite] [Details]

Citations: Scopus - 5Web of Science - 3

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2017Alty J, Cosgrove J, Thorpe D, Kempster P, 'How to use pen and paper tasks to aid tremor diagnosis in the clinic', Practical Neurology, 17, (6) pp. 456-463. ISSN 1474-7758 (2017) [Refereed Article]

DOI: 10.1136/practneurol-2017-001719 [eCite] [Details]

Citations: Scopus - 23

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2017Lones MA, Alty JE, Cosgrove J, Duggan-Carter P, Jamieson S, et al., 'A new evolutionary algorithm-based home monitoring device for Parkinson's dyskinesia', Journal of Medical Systems, 41, (176) pp. 1-8. ISSN 0148-5598 (2017) [Refereed Article]

DOI: 10.1007/s10916-017-0811-7 [eCite] [Details]

Citations: Scopus - 11Web of Science - 10

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2017Newby RE, Thorpe DE, Kempster PA, Alty JE, 'A history of dystonia: Ancient to modern', Movement Disorders Clinical Practice, 4, (4) pp. 478-485. ISSN 2330-1619 (2017) [Refereed Article]

DOI: 10.1002/mdc3.12493 [eCite] [Details]

Citations: Scopus - 15

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2017Shanmugarajah PD, Alty J, Lily O, Ford HL, 'Lesson of the month 2: Transient reversible amnesia in multiple sclerosis', Clinical Medicine, 17, (1) pp. 88-90. ISSN 1470-2118 (2017) [Contribution to Refereed Journal]

DOI: 10.7861/clinmedicine.17-1-88 [eCite] [Details]

Citations: Scopus - 1

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2016Alty J, Robson J, Duggan-Carter P, Jamieson S, 'What to do when people with Parkinson's disease cannot take their usual oral medications', Practical Neurology, 16, (2) pp. 122-128. ISSN 1474-7758 (2016) [Refereed Article]

DOI: 10.1136/practneurol-2015-001267 [eCite] [Details]

Citations: Scopus - 16

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2016Ding C, Ganesvaran G, Alty JE, Clissold BG, McColl CD, et al., 'Study of levodopa response in Parkinson's disease: observations on rates of motor progression', Movement Disorders, 31, (4) pp. 589-592. ISSN 0885-3185 (2016) [Refereed Article]

DOI: 10.1002/mds.26497 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

Co-authors: Srikanth V

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2016Turner AP, Lones MA, Trefzer MA, Smith SL, Jamieson S, et al., 'Using epigenetic networks for the analysis of movement associatedwith levodopa therapy for Parkinson's disease', Biosystems, 146 pp. 35-42. ISSN 0303-2647 (2016) [Refereed Article]

DOI: 10.1016/j.biosystems.2016.05.005 [eCite] [Details]

Citations: Scopus - 2Web of Science - 3

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2015Alty JE, Cosgrove J, Jamieson S, Smith SL, Possin KL, 'Which figure copy test is more sensitive for cognitive impairment in Parkinson's disease: Wire cube or interlocking pentagons?', Clinical Neurology and Neurosurgery, 139 pp. 244-246. ISSN 0303-8467 (2015) [Refereed Article]

DOI: 10.1016/j.clineuro.2015.10.019 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

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2015Cosgrove J, Alty JE, Jamieson S, 'Cognitive impairment in Parkinson's disease', Postgraduate Medical Journal, 91, (1074) pp. 212-220. ISSN 0032-5473 (2015) [Refereed Article]

DOI: 10.1136/postgradmedj-2015-133247 [eCite] [Details]

Citations: Scopus - 46Web of Science - 40

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2015Newby R, Jamieson S, Udd B, Alty J, 'When myopathy breaks the rules: A late-onset distal presentation', BMJ Case Reports, 2015 pp. bcr2015209436. ISSN 1757-790X (2015) [Contribution to Refereed Journal]

DOI: 10.1136/bcr-2015-209436 [eCite] [Details]

Citations: Scopus - 2

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2015Smith SL, Lones MA, Bedder M, Alty JE, Cosgrone J, et al., 'Computational approaches for understanding the diagnosis and treatment of Parkinson's disease', IET Systems Biology, 9, (6) pp. 226-233. ISSN 1751-8849 (2015) [Refereed Article]

DOI: 10.1049/iet-syb.2015.0030 [eCite] [Details]

Citations: Scopus - 13Web of Science - 10

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2015Thorpe DE, Alty JE, 'What type of tremor did the medieval 'Tremulous Hand of Worcester' have?', Brain, 138, (10) pp. 3123-3127. ISSN 0006-8950 (2015) [Refereed Article]

DOI: 10.1093/brain/awv232 [eCite] [Details]

Citations: Scopus - 9Web of Science - 7

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2013Ganga G, Alty JE, Clissold BG, Craig D, Reardon KA, et al., 'Longitudinal study of levodopa in Parkinson's disease: effects of the advanced disease phase', Movement Disorders, 28, (4) pp. 476-481. ISSN 0885-3185 (2013) [Refereed Article]

DOI: 10.1002/mds.25335 [eCite] [Details]

Citations: Scopus - 17Web of Science - 14

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2013Richfield EW, Jones EJS, Alty JE, 'Palliative care for Parkinson's disease: a summary of the evidence and future directions', Palliative Medicine, 27, (9) pp. 805-810. ISSN 0269-2163 (2013) [Contribution to Refereed Journal]

DOI: 10.1177/0269216313495287 [eCite] [Details]

Citations: Scopus - 60Web of Science - 52

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2011Alty JE, Kempster PA, 'A practical guide to the differential diagnosis of tremor', Postgraduate Medical Journal, 87, (1031) pp. 623-9. ISSN 0032-5473 (2011) [Contribution to Refereed Journal]

DOI: 10.1136/pgmj.2009.089623 [eCite] [Details]

Citations: Scopus - 25Web of Science - 15

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2011Wong KK, Alty JE, Goy AG, Raghav S, Reutens DC, et al., 'A randomized, double-blind, placebo-controlled trial of levetiracetam for dyskinesia in Parkinson's disease', Movement Disorders, 26, (8) pp. 1552-1555. ISSN 0885-3185 (2011) [Refereed Article]

DOI: 10.1002/mds.23687 [eCite] [Details]

Citations: Scopus - 24Web of Science - 24

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2009Alty JE, Clissold BJ, McColl CD, Reardon KA, Shiff M, et al., 'Longitudinal study of the levodopa motor response in Parkinson's disease: relationship between cognitive decline and motor function', Movement Disorders, 24, (16) pp. 2337-43. ISSN 0885-3185 (2009) [Refereed Article]

DOI: 10.1002/mds.22800 [eCite] [Details]

Citations: Scopus - 13Web of Science - 8

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2008Alty JE, Ford HL, 'Multi-system complications of hypothermia: a case of recurrent episodic hypothermia with a review of the pathophysiology of hypothermia', Postgraduate Medical Journal, 84, (992) pp. 282-286. ISSN 0032-5473 (2008) [Contribution to Refereed Journal]

DOI: 10.1136/pgmj.2007.066050 [eCite] [Details]

Citations: Scopus - 21Web of Science - 18

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2008Alty JE, Kempster P, Raghav S, 'Cluster-like headache secondary to trigeminal meningioma', Neuroscience, 70, (20) ISSN 0306-4522 (2008) [Contribution to Refereed Journal]

DOI: 10.1212/01.wnl.0000312286.64144.2e [eCite] [Details]

Citations: Scopus - 7Web of Science - 7

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2008Kempster PA, Alty JE, 'John Ruskin's relapsing encephalopathy', Brain, 131, (9) pp. 2520-2525. ISSN 0006-8950 (2008) [Refereed Article]

DOI: 10.1093/brain/awn019 [eCite] [Details]

Citations: Scopus - 7Web of Science - 6

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2007Alty JE, Monaghan TM, Bamford JM, 'A patient with neuro-Behcet's disease is successfully treated with etanercept: Further evidence for the value of TNFα blockade', Clinical Neurology and Neurosurgery, 109, (3) pp. 279-281. ISSN 0303-8467 (2007) [Contribution to Refereed Journal]

DOI: 10.1016/j.clineuro.2006.11.002 [eCite] [Details]

Citations: Scopus - 44Web of Science - 36

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2005Khattar RS, Fox DJ, Alty JE, Arora A, 'Pulmonary artery dissection: An emerging cardiovascular complication in surviving patients with chronic pulmonary hypertension', Heart, 91, (2) pp. 142-145. ISSN 1355-6037 (2005) [Contribution to Refereed Journal]

DOI: 10.1136/hrt.2004.045799 [eCite] [Details]

Citations: Scopus - 68Web of Science - 61

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Book

(3 outputs)
YearCitationAltmetrics
2013Alty J, Hoey E, 'Practical Ultrasound: An Illustrated Guide', CRC Press, United Kingdom, pp. 295. ISBN 9781444168297 (2013) [Authored Other Book]

[eCite] [Details]

2011Hoey E, Alty J, Mankad K, 'Clinical Ultrasound: Case Reviews', Anshan Ltd, United Kingdom, pp. 230. ISBN 9781848290495 (2011) [Authored Other Book]

[eCite] [Details]

2006Alty J, Hoey E, 'Practical Ultrasound: An Illustrated Guide', Hodder Education Publishers, United Kingdom, pp. 256. ISBN 978-1853156038 (2006) [Authored Other Book]

[eCite] [Details]

Chapter in Book

(2 outputs)
YearCitationAltmetrics
2022Hurta M, Drahosova M, Sekanina L, Smith SL, Alty JE, 'Evolutionary Design of Reduced Precision Levodopa-Induced Dyskinesia Classifiers', Genetic Programming (Lecture Notes in Computer Science, vol 13223), Springer, Cham, E Medvet, G Pappa, and B Xue (ed), Switzerland, pp. 85-101. ISBN 978-3-031-02055-1 (2022) [Research Book Chapter]

DOI: 10.1007/978-3-031-02056-8_6 [eCite] [Details]

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2015Alty J, Cosgrove J, 'Neurological and neurosurgical complications of alcohol', ABC in Alcohol, Wiley-Blackwell Publishing Ltd., A McCune (ed), United Kingdom, pp. 64-68. ISBN 978-1-118-54479-2 (2015) [Other Book Chapter]

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Conference Publication

(21 outputs)
YearCitationAltmetrics
2022Alty J, Salmon K, Lawler K, McDonald S, Stuart K, et al., 'The ISLAND clinic: first year outcomes of a new state-wide one-stop' cognitive clinic in Tasmania', ADRF - Australian Dementia Research Forum, 30-31 May 2022, Online (2022) [Conference Extract]

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Co-authors: Salmon K; Lawler K; McDonald S; Stuart K; Cleary A; Beaumont M; Radfar N; Collins J; Ma WJ; King A; Vickers J

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2022Alty JE, 'Diagnosis of Parkinson's disease', Coalface Geriatrics Conference, 31 Aug - 3 Sept 2022, Newcastle, Australia (2022) [Plenary Presentation]

[eCite] [Details]

2022Alty JE, 'Tremors: a practical approach', Coalface Geriatrics Conference, 31 Aug - 3 Sept 2022, Newcastle, Australia (2022) [Plenary Presentation]

[eCite] [Details]

2022Costa S, St George RJ, McDonald S, Wang X, Alty J, 'Diagnostic accuracy of the overlapping infinity loops, wire cube, and clock drawing tests in subjective cognitive impairment, mild cognitive impairment and dementia', Australian Dementia Research Forum 2022 (ADFR), 30-31 May 2022, Online (2022) [Conference Extract]

[eCite] [Details]

Co-authors: St George RJ; McDonald S; Wang X

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2022Khan S, Williams S, Cosgrove J, Bamford J, Alty J, 'Widening the phenotype of FXTAS in females: Spasmodic dysphonia in two patients', Movement Disorders ISSN 0885-3185 (2022) [Conference Extract]

[eCite] [Details]

2022Lin X, Wallis K, Brodaty H, Kain B, Cooper S, et al., 'Patients' and carers' experience of dementia and memory services: Early findings from the Australian Dementia Network (ADNeT) Registry', Australian Dementia Research Forum 2022 (ADFR), 30-31 May 2022, Online (2022) [Conference Extract]

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2022Sosa J, Perry S, Alty J, Hogg D, 'Of Mice and Pose: 2D Mouse Pose Estimation from Unlabelled Video Frames using Synthetic Data', CV4Animals: Computer Vision for Animal Behavior Tracking and Modeling, 19 - 24 June 2022, New Orleans, United States (2022) [Conference Extract]

[eCite] [Details]

Co-authors: Perry S

2021Abela M, Maxwell H, Alty JE, Lawler K, Bindoff AD, et al., 'Physical activity for dementia risk reduction - not as easy as it sounds', 2021 Australian Dementia Forum, 31 May - 1 June 2021, online (2021) [Conference Extract]

[eCite] [Details]

Co-authors: Abela M; Maxwell H; Lawler K; Bindoff AD; Farrow M

2021Alty J, Bai Q, St George RJ, Bindoff A, Li R, et al., 'TasTest: moving towards a digital screening test for pre-clinical Alzheimer's disease', Biomarkers ISSN 1354-750X (2021) [Conference Extract]

DOI: 10.1002/alz.058732 [eCite] [Details]

Co-authors: Bai Q; St George RJ; Bindoff A; Li R; Lawler K; Hill E; Garg G; Bartlett L; King AE; Vickers JC

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2021Hill E, Collins J, Bindoff A, King A, Alty J, et al., 'Increased age and higher levels of cognitive reserve are associated with lower serum BDNF levels in healthy older adults', Australian Dementia Forum 2021, 31 May - 1 June, virtual (2021) [Conference Extract]

[eCite] [Details]

Co-authors: Hill E; Collins J; Bindoff A; King A; Summers M; Vickers J

2020Bartlett L, Doherty K, Farrow M, Bindoff A, Kim S, et al., 'Poster - The island study linking ageing and neurodegenerative disease (ISLAND): a longitudinal public health research program targeting dementia risk reduction', 2020 Alzheimer's Association International Conference, 26-30 July 2020, Online (2020) [Conference Extract]

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Co-authors: Bartlett L; Doherty K; Farrow M; Bindoff A; Kim S; Eccleston C; Hill E; King E; Vickers JC

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2020Bartlett L, Doherty K, Farrow M, Bindoff A, Kim S, et al., 'The Island Study Linking Ageing and Neurodegenerative Disease (ISLAND): A longitudinal public health research program targeting dementia risk reduction', Alzheimer's & Dementia ISSN 1552-5260 (2020) [Conference Extract]

DOI: 10.1002/alz.045539 [eCite] [Details]

Co-authors: Bartlett L; Doherty K; Farrow M; Bindoff A; Kim S; Eccleston C; Hill E; King AE; Vickers JC

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2020Zhao Z, Fang H, Williams S, Relton SD, Alty J, et al., 'Time series clustering to examine presence of decrement in Parkinson's finger-tapping bradykinesia', 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 20-24 July 2020, Montreal, QC, Canada, pp. 780-783. ISBN 9781728119908 (2020) [Refereed Conference Paper]

DOI: 10.1109/EMBC44109.2020.9175638 [eCite] [Details]

Citations: Scopus - 1

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2019Alty J, 'Clinical examination in Parkinson's disease', World Congress in Geriatric Medicine - Back to the roots, 30 August - 3 September, Newcastle NSW, Australia (2019) [Plenary Presentation]

[eCite] [Details]

2019Alty J, Bindoff A, Stuart K, Klekociuk S, Vickers J, 'Cognitive reserve in the baseline data of Tasmanian Healthy Brain Project: No effect of age or interaction with gender', The fourth annual NHMRC National Institute for Dementia Research (NNIDR) Australian Dementia Forum, 13-14 June, Hobart, Tasmania (2019) [Conference Extract]

[eCite] [Details]

Co-authors: Bindoff A; Stuart K; Klekociuk S; Vickers J

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2019Xia T, Cosgrove J, Alty J, Jamieson S, Smith J, 'Application of classification for figure copying test in Parkinson's disease diagnosis by using cartesian genetic programming', GECCO '19 Companion, 13-17 July, Prague, Czech Republic, pp. 1855-1863. ISBN 978-1-4503- 6748-6 (2019) [Refereed Conference Paper]

DOI: 10.1145/3319619.3326822 [eCite] [Details]

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2018Muhamed SA, Newby R, Smith SL, Alty J, Jamieson S, et al., 'Objective evaluation of Bradykinesia in Parkinson's disease using evolutionary algorithms', Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018), 19-21 January, Funchal, Madeira, Portugal, pp. 63-69. ISBN 978-989-758-279-0 (2018) [Refereed Conference Paper]

DOI: 10.5220/0006601700630069 [eCite] [Details]

Citations: Scopus - 4

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2017Lones MA, Alty J, Duggan-Carter P, Turner AJ, Jamieson DRS, et al., 'Going through directional changes: evolving human movement classifiers using an event based encoding', GECCO '17: Proceedings of the Genetic and Evolutionary Computation Conference Companion, 15-19 July, Berlin, Germany, pp. 1365-1371. ISBN 978-1-4503-4939-0 (2017) [Refereed Conference Paper]

DOI: 10.1145/3067695.3082490 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2016Vallejo M, Cosgrove J, Alty JE, Jamieson S, Smith SL, et al., 'Exploring diagnostic models of Parkinson's disease with multi-objective regression', 2016 IEEE Symposium Series on Computational Intelligence (SSCI) - Proceedings, 6-9 December, Athens, Greece, pp. 1-8. ISBN 978-1-5090-4240-1 (2016) [Refereed Conference Paper]

DOI: 10.1109/SSCI.2016.7849884 [eCite] [Details]

Citations: Scopus - 2

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2015Filby A, Lewis L, Taylor M, Smith SL, Dettmar PW, et al., 'Cost effectiveness analysis of a device to monitor levodopa-induced dyskinesia in Parkinson's patients', ISPOR 18th Annual European Congress, 7-11 November, Milan, Italy, pp. A358. ISSN 1098-3015 (2015) [Conference Extract]

DOI: 10.1016/j.jval.2015.09.682 [eCite] [Details]

Citations: Web of Science - 1

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2015Lones MA, Alty JE, Duggan-Carter P, Turner AJ, Jamieson DRS, et al., 'Classification and characterisation of movement patterns during levodopa therapy for parkinson's disease', 2014 Annual Conference on Genetic and Evolutionary Computation (GECCO'14), 12-16 July, Vancouver, BC, Canada, pp. 1321-1328. ISBN 978-1-4503-2881-4 (2015) [Refereed Conference Paper]

DOI: 10.1145/2598394.2609852 [eCite] [Details]

Citations: Scopus - 5

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Major Creative Work

(1 outputs)
YearCitationAltmetrics
2017Thorpe D, Alty J, Smith SL, Austin J, Hufton S, et al., 'Tremulous Hands', University of York, United Kingdom (2017) [Broadcast]

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Other Public Output

(3 outputs)
YearCitationAltmetrics
2021Alty JE, ''Interview with Dr Jane Alty, Wicking Dementia Research and Education Centre' interview by Neil Broomfield', Print Radio Tasmania, Print Radio Tasmania, Tasmania, 15 July 2021 (2021) [Media Interview]

[eCite] [Details]

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2021Alty JE, ''Second Interview with Dr Jane Alty, Wicking Dementia Research and Education Centre' interview by Neil Broomfield', Print Radio Tasmania, Print Radio Tasmania, Australia, 25 November 2021 (2021) [Media Interview]

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2021Alty JE, 'Tassie researchers at forefront of early warning test for dementia - Newspaper interview by Sue Bailey', Sunday Tasmanian, The Mercury, Australia, 8 May 2021 (2021) [Newspaper Article]

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Grants & Funding

In her first 4 years (0.6-0.8 FTE) at the University of Tasmania,  A/Prof Alty  has been awarded more than 10 research grants of >$3.26M including as Chief Investigator A on an NHMRC Ideas grant ($899k 2021-25) and Chief Investigator A on an RHHRF Major Project grant ($446k; 2022-24). She was also the lead co-applicant for a University infrastructure grant of >$500k to build a new human movement analysis centre in Hobart.

Funding Summary

Number of grants

10

Total funding

$3,258,122

Projects

Detecting dementia risk by wearing a watch: Evaluation of sleep/wake patterns to identify REM sleep behaviour disorder (RBD) in Tasmania (2023)$9,700
Description
Adults with RBD have a 90% chance of developing dementia or another neurodegenerative disease (ND) within 10 years. However, RBD is difficult to diagnose. This project will evaluate 24-hour actigraphy (activity) watches for detecting probable RBD (pRBD) in Tasmania.
Funding
Royal Hobart Hospital Research Foundation ($9,700)
Scheme
Grant-Incubator
Administered By
University of Tasmania
Research Team
Alty JE; King AE; Kuruvilla M
Year
2023
Exploring clinic manifestations of late-onset Essential Tremor: a pre-cognitive biomarker of dementia? (2023)$24,966
Description
Shaking up our approach to detecting dementia: using tremor analysis to develop a new pre-cognitive test of dementia risk
Funding
Royal Hobart Hospital Research Foundation ($24,966)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Wang X; Alty JE; St George RJ; Lawler K; Ruthnam L; Collins J; Rudd KD
Year
2023
Sniffing out Dementia: Olfactory dysfunction in an at risk group of older Tasmanians (2022)$5,000
Description
Donation in support of Samantha Bramich's (PhD Student) researchThis project will characterise who is at highest risk of developing dementia in an enriched cohort of people with probable REM Sleep Behaviour Disorder (pRBD) and compare a simple smell test against an expensive-time consuming sleep study in the diagnosis of RBD. RBD is a sleep disorder that is characterised by enactment of motor behaviours throughout vivid dreaming episodes in Rapid Eye Movement (REM) sleep. It is an early clinical sign of abnormal synuclein proteins in the brain. The funding will be used to purchase approximately 100 University of Pennsylvania Smell Identification Tests (UPSIT), the gold standard validated measure of olfactory function, to be used with a sample of participants in the ISLAND Sleep Study who are found to have pRBD through a validated screening questionnaire.
Funding
Donation via University of Tasmania Foundation ($5,000)
Scheme
Donation - Individual
Administered By
University of Tasmania
Research Team
Alty JE; Kuruvilla M; Beauchamp L
Year
2022
Development of a non-invasive screening test to detect risk of Alzheimer's disease pathology (2022 - 2024)$446,957
Description
Alzheimer's disease (AD) starts damaging the brain >10 years before memory problems begin. To reduce dementia incidence, we must detect AD earlier so we can target prevention through early clinical trial recruitment and risk reduction (that could prevent 40% cases). With 10,000 available UTAS research participants and 200 patients from RHH and the community, we aim to develop a test to detect early signs of AD by analysing hand- AND speech- movements using a smartphone and machine learning algorithms.
Funding
Royal Hobart Hospital Research Foundation ($446,957)
Scheme
Grant-Major Project
Administered By
University of Tasmania
Research Team
Alty JE; Goldberg LR; Roccati E; Lawler K; Bhagwat A; Fernando N; Bartlett L; Bindoff AD; Bai Q; Vickers JC
Period
2022 - 2024
Identifying older adults in Tasmania with REM Sleep Behaviour Disorder(RBD): the crucial first step towards reducing their high risk of neurodegeneration. (2022)$24,818
Description
Adults with RBD have a 90% chance of developing dementia or other neurodegenerative disease (ND) within 10 years. However, RBD is under-recognised. This project will identify RBD prevalence in Tasmania, characterise its associated features, and offer risk reduction strategies with the long-term aim of decreasing the incidence of ND.
Funding
Royal Hobart Hospital Research Foundation ($24,818)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Bramich S; Alty JE; King AE; Kuruvilla M
Year
2022
Development and Validation of a contactless tool for measuring patient tremor (2022)$375,467
Description
To diagnose the cause of a tremor, doctors look at a patient's hands and make a visual assessment. It is difficult to make precise judgements of tremor by eye, even for experts. This means that diagnosis and treatment decisions can be inaccurate or delayed. We will address this problem by developing a contactless tool that can measure tremor in patients' hands using video. We have already developed methods that accurately measure tremor rhythm from smartphone videos. In this project, we will 1.) develop a method to measure tremor size, 2.) create an application to measure tremor size and rhythm using a smartphone or webcam video. The tool will be designed for use in face-to-face appointments or over video consultations. 3.) extend our tool so that researchers can save video data for future clinical studies.
Funding
National Institute for Health Research ($375,467)
Scheme
Grant-Invention for Innovation
Administered By
University of Manchester
Research Team
Wong D; Alty JE
Year
2022
The future in our hands: Screening for preclinical Alzheimer's disease by analysing hand movements (2021 - 2025)$899,782
Description
Global dementia prevalence is rising. Alzheimer's disease (AD), the most common cause, has devastating effects on people's quality of life. AD has a preclinical (pre-AD) period of 10-20 years when brain pathology silently progresses before any cognitive symptoms appear. Current tests for pre-AD are invasive, costly and unsuitable for screening at population level. If we can't identify people with pre-AD, we can't offer them early interventions. This hinders our strategies to reduce AD prevalence. We will develop a new scalable test (HandTest) by combining two innovative ideas: hand-movement tests to detect pre-AD >10 years before cognitive symptoms begin; and computer vision so people can self-test online at home. This unique approach builds on the recent discoveries that the posterior cingulate cortex (the first brain region to show abnormalities in pre-AD) is involved in hand-movement control, and that hand-movement patterns change in pre-AD. We will use exquisitely precise computer vision methods to automatically analyse movement data from thousands of participants, who complete the online test by simply opening and closing their hands repeatedly for 5 minutes in front of a standard computer, tablet or smartphone camera. The CI/AI team of experts in hand-movement analysis, pre-AD, computer vision, AD biomarkers and biostatistics has access to 3 well-phenotyped cohorts, >10,000 existing participants and a cutting-edge assay for a blood AD biomarker, ptau181. We will develop a HandTest algorithm to classify hand-movement data for pre-AD risk. In a longitudinal cohort we will determine HandTest's precision to prospectively predict 5-year risks of cognitive decline and AD. This is the critical first step for up-scaling HandTest nationwide via memory clinics of the Australian Dementia Network. With worldwide access to computers, tablets and smartphones increasing, HandTest is scalable globally, potentially transforming dementia prevention and management.
Funding
National Health & Medical Research Council ($899,782)
Scheme
Grant-Ideas
Administered By
University of Tasmania
Research Team
Alty JE; Vickers JC; Bai Q; Bindoff AD; Roccati E
Period
2021 - 2025
Grant Reference
2004051
A new model of shared care across Geriatric Medicine and General Surgery for older Tasmanians. (2021)$25,000
Description
Older Tasmanians undergoing emergency surgery are at high risk of complications and of subsequently needing rehabilitation or nursing home placement following discharge. We will investigate the need for a novel model of shared Geriatric/General Surgery care for older RHH patients, and measure its effect on return to pre-admission residence and in-hospital complications.
Funding
Royal Hobart Hospital Research Foundation ($25,000)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Evans T; Ferrah N; Turner RC; Jose M; Britcliffe A; Alty JE; Vickers JC; Campbell JA
Year
2021
Blood-based biomarkers for neurodegeneration dementia (2020 - 2022)$449,386
Description
This project will characterise a blood biomarker of neurodegeneration for prognostic and diagnostic value to predict cognitive decline and dementia.
Funding
Royal Hobart Hospital Research Foundation ($449,386)
Scheme
Grant-Major Project
Administered By
University of Tasmania
Research Team
Collins J; Vickers JC; King AE; Alty JE; Cooper PD
Period
2020 - 2022
HDAC6 inhibition to rescue axon degeneration in ALS (2019 - 2023)$997,046
Description
We will test an HDAC6 inhibitor in models of ALS. We will investigate the HDA6 inhibitor activity of novel compounds
Funding
FightMND ($997,046)
Scheme
Grant - Drug Development Grant
Administered By
University of Tasmania
Research Team
King AE; Cook AL; Guven N; Van Den Bosch L; Dickson TC; Blizzard C; Vickers JC; Smith JA; Alty JE; Leung JY; Perry SE
Period
2019 - 2023

Research Supervision

A/Prof Jane Alty  promotes a culture of research excellence and she is actively sought as a supervisor. Her supervision style is ‘coaching’, tailoring the level of support and structure to facilitate the student gradually developing their own research autonomy. She has a track record of successful UTAS PhD scholarship applications. She currently is primary supervisor for 4 PhD students, co-supervisors several other, and has had 3 timely completions. She has also supervised 2 Honours projects and 2 Masters projects.  A/Prof Alty welcomes enquiries from HDR candidates and is particularly interested to hear from candidates who have experience in data analysis and computer science (but these are not essential).

Current

10

Current

DegreeTitleCommenced
PhDIdentifying Pre-cognitive Biomarkers of the Earliest Stages of Dementia using Artificial Intelligence Analyses of Eye, Face and Limb Movements2019
PhDA Clinical Support Tool to Aid Delivering a Diagnosis of Dementia Well. A mixed methods study2020
PhDPost-diagnostic Support in Australian Memory Clinics2020
PhDREM Sleep Behaviour Disorder: Prevalence and cognitive characteristics2020
PhDApplying Artificial Intelligence to Identify New Tremor Biomarkers of Dementia Risk2021
PhDA brighter future for healthy ageing: developing minimally invasive Brain Health biomarkers (ISLAND Study Linking Ageing and Neurodegenerative Disease)2021
PhDMotor function and dementia: Assessing the relationships between aging, motor function and dementia2022
PhDStopping (in) Cognitive Decline: How is the ability to stop and adapt ongoing movements affected by neurocognitive disorders?2022
PhDDetecting Dementia Risk with TAS Test through Deep Learning of Hand Movement, Visuo-motor and Speech Datasets2022
PhDTongue Strength and Dementia2022