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Matthew Kirkcaldie

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Matthew Kirkcaldie

Senior Lecturer in Neuroscience

Room 421A (Level 4), Medical Science 1

+61 3 6226 2662 (phone)

+61 3 6226 2679 (fax)

Matthew.Kirkcaldie@utas.edu.au

Dr Matthew Kirkcaldie is a Senior Lecturer in Neuroscience in the School of Medicine. His research interests include the neuronal cytoskeleton and plasticity, the pathology of Alzheimer's disease, the development, structure and function of the cerebral cortex, and the similarities between the brains of different animal species. In addition to research publications, Dr Kirkcaldie is an author of several reference works about rodent brains, and has written an introductory textbook on neuroscience which is used as the reference for a national neuroanatomy competition.

Biography

Matthew completed a BSc(hons) at the University of Tasmania in psychophysics, followed by a PhD in neuropathology in the School of Medicine. After his PhD, Matthew worked in postdoctoral research and teaching positions at the University of Newcastle and the University of New South Wales, working in plasticity, sensory electrophysiology and comparative neuroanatomy, and forming collaborations with internationally renowned neuroanatomists and neurophysiologists. He returned to Tasmania in 2007 to take on an active role in the teaching of neuroscience in the medicine and biomedical research degrees. In addition to these responsibilities he supervises graduate research students from a range of disciplines (biomed science, computer science, psychology, paramedicine) and is involved with national neuroscience education programmes.

Career summary

Qualifications

  • PhD, University of Tasmania, Australia, 2001. Thesis:  The neurofilament triplet protein and other neurochemical markers in rat neocortex
  • BSc (1st Class Hons), University of Tasmania, Australia, 1995. Thesis: Semantics, automaticity and attention

Memberships

Professional practice

  • Society for Neuroscience (USA)
  • Australasian Neuroscience Society

Administrative expertise

Dr Kirkcaldie acts as unit and year coordination in the MBBS and Bachelor of Medical Research.

Teaching

Neuroscience, neuroanatomy, brain, cortex, neocortex, sensory systems, motor control, memory, evolutionary biology, research methods, plasticity, behaviour, physiology, enteric nervous system, gastrointestinal physiology.

Teaching expertise

Dr Kirkcaldie has extensive experience in undergraduate medical education including curriculum design and accreditation both at the University of Tasmania and the University of New South Wales. Matthew has 15 years of undergraduate and graduate teaching experience in neuroscience, research methods and physiology. As a passionate science communicator, Matt also has 5 years of outreach secondary schools experience (running in-school sessions, school visits for brain dissections, and the Brain Bee competition).

Matthew has been instrumental in designing the curriculum for the current Bachelor of Medical Science degree at the University of Tasmania and is in the process of establishing a national network for neuroscience curriculum through the Australasian Neuroscience Society (ANS).

Teaching responsibility

Unit coordinator:

Units taught:

View more on Dr Matthew Kirkcaldie in WARP

Expertise

  • Cerebral cortex
  • Brain evolution
  • Comparative neuroanatomy
  • Alzheimer's disease
  • Brain development

Research Themes

Dr Kirkcaldie's work aligns with the research theme of Better Health. By understanding key similarities between the human brain and commonly used research species, he aims to improve the use of animal models of significant human diseases such as Alzheimer's and motor neuron disease (MND) or amyotrophic lateral sclerosis (ALS). One of his major current research interests is to understand potential risk factors for developing neurodegenerative diseases. His group studies the function and dysfunction of the nervous system at the cellular level, working mostly with mouse and rat models, and are currently investigating the most accurate way to measure pathology as it develops in brain tissues, as well as the response of the brain to traumatic injury.

Collaboration

Matthew has active collaborations with Professor Charles Watson (Curtin, WA) on comparative neuroanatomy, and Professor John Morley (UNSW/UWS, NSW) on sensory physiology.

Current projects

  • Characterising the effects of general anaesthesia and sedatives on the pathology of Alzheimer's disease.
  • A study of local spinal cord plasticity as a contributor to the pathology of amyotrophic lateral sclerosis (ALS).

Fields of Research

  • Neurosciences (110999)
  • Central Nervous System (110903)
  • Cellular Nervous System (110902)

Research Objectives

  • Nervous System and Disorders (920111)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Expanding Knowledge in the Medical and Health Sciences (970111)

Publications

In addition to publishing journal articles Dr Kirkcaldie has written several books and chapters, as well as co-authoring a major brain atlas (Paxinos G, Watson C, Carrive P, Kirkcaldie MTK, Ashwell KWS. Chemoarchitectonic Atlas of the Rat Brain, Academic Press 2009). His books include an introductory textbook (Watson C, Kirkcaldie MTK, Paxinos G. The Brain: An Introduction to Functional Neuroanatomy, Academic Press, 2010) as well as major chapters for The Mouse Nervous System (Watson C, Paxinos G, Puelles L (eds.), Academic Press, 2012), The Constitution of Visual Consciousness: Lessons from Binocular Rivalry (Miller SM (ed.) John Benjamins Publishing Company, 2013) and The Brain Book (Ashwell KWS (ed.) Palgrave Macmillan, 2012).

Total publications

41

Highlighted publications

(8 outputs)
YearTypeCitationAltmetrics
2013Journal ArticleMitew S, Kirkcaldie MTK, Dickson TC, Vickers JC, 'Altered synapses and gliotransmission in Alzheimer's disease and AD model mice', Neurobiology of Aging, 34, (10) pp. 2341-2351. ISSN 0197-4580 (2013) [Refereed Article]

DOI: 10.1016/j.neurobiolaging.2013.04.010 [eCite] [Details]

Citations: Scopus - 75Web of Science - 74

Co-authors: Mitew S; Dickson TC; Vickers JC

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2011Chapter in BookKirkcaldie MTK, 'Neocortex', The Mouse Nervous System, Academic Press, C Watson, G Paxinos and L Puelles (ed), San Diego, pp. 52 - 111. ISBN 9780123694973 (2011) [Research Book Chapter]

DOI: 10.1016/B978-0-12-369497-3.10004-4 [eCite] [Details]

Citations: Scopus - 14

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2010Journal ArticleMitew S, Kirkcaldie MTK, Halliday G, Shepherd CE, Vickers JC, et al., 'Focal demyelination in Alzheimer's disease and transgenic mouse models', Acta Neuropathologica, 119, (5) pp. 567-577. ISSN 0001-6322 (2010) [Refereed Article]

DOI: 10.1007/s00401-010-0657-2 [eCite] [Details]

Citations: Scopus - 74Web of Science - 64

Co-authors: Mitew S; Vickers JC; Dickson TC

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2010BookWatson CRR, Kirkcaldie MTK, Paxinos G, 'The Brain: An Introduction to Functional Neuroanatomy', Elsevier, Tokyo, pp. 215. ISBN 978-0-12-373889-9 (2010) [Authored Other Book]

[eCite] [Details]

2009BookPaxinos G, Watson C, Carrive P, Kirkcaldie MTK, Ashwell K, 'Chemoarchitectonic Atlas of the Rat Brain', Elsevier, USA, pp. 375. ISBN 978-0-12-374237-7 (2009) [Authored Research Book]

[eCite] [Details]

2007Journal ArticleKirkcaldie MTK, Kitchener PD, 'When brains expand: mind and the evolution of cortex', Acta Neuropsychiatrica, 19, (3) pp. 139-148. ISSN 0924-2708 (2007) [Refereed Article]

DOI: 10.1111/j.1601-5215.2007.00204.x [eCite] [Details]

Citations: Scopus - 11Web of Science - 10

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2002Journal ArticleKirkcaldie MTK, Dickson TC, King CE, Grasby DJ, Riederer BM, et al., 'Neurofilament triplet proteins are restricted to a subset of neurons in the rat neocortex', Journal of Chemical Neuroanatomy, 24, (3) pp. 163-171. ISSN 0891-0618 (2002) [Refereed Article]

DOI: 10.1016/S0891-0618(02)00043-1 [eCite] [Details]

Citations: Scopus - 58Web of Science - 55

Co-authors: Dickson TC; King CE; Vickers JC

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1997Journal ArticleKirkcaldie MTK, Pridmore S, Pascual-Leone A, 'Transcranial magnetic stimulation as therapy for depression and other disorders', Australian and New Zealand Journal of Psychiatry, 31, (2) pp. 264-272. ISSN 0004-8674 (1997) [Refereed Article]

DOI: 10.3109/00048679709073830 [eCite] [Details]

Citations: Scopus - 42Web of Science - 41

Co-authors: Pridmore S

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Journal Article

(23 outputs)
YearCitationAltmetrics
2019Collins JM, King AE, Woodhouse A, Kirkcaldie MTK, Vickers JC, 'Age moderates the effects of traumatic brain injury on beta-amyloid plaque load in APP/PS1 mice', Journal of Neurotrauma, 36, (11) pp. 1876-1889. ISSN 0897-7151 (2019) [Refereed Article]

DOI: 10.1089/neu.2018.5982 [eCite] [Details]

Citations: Scopus - 1Web of Science - 3

Co-authors: Collins JM; King AE; Woodhouse A; Vickers JC

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2018O'Mara AR, Collins JM, King AE, Vickers JC, Kirkcaldie MTK, 'Accurate and unbiased quantitation of Amyloid-β fluorescence images using ImageSURF', Current Alzheimer Research, 16, (2) pp. 102-108. ISSN 1567-2050 (2018) [Refereed Article]

DOI: 10.2174/1567205016666181212152622 [eCite] [Details]

Co-authors: O'Mara AR; Collins JM; King AE; Vickers JC

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2017O'Mara A, King AE, Vickers JC, Kirkcaldie MTK, 'ImageSURF: An ImageJ plugin for batch pixel-based image segmentation using random forests', Journal of Open Research Software, 5 Article 31. ISSN 2049-9647 (2017) [Refereed Article]

DOI: 10.5334/jors.172 [eCite] [Details]

Co-authors: O'Mara A; King AE; Vickers JC

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2016King AE, Woodhouse A, Kirkcaldie MTK, Vickers JC, 'Excitotoxicity in ALS: Overstimulation, or overreaction?', Experimental Neurology, 275 pp. 162-171. ISSN 0014-4886 (2016) [Refereed Article]

DOI: 10.1016/j.expneurol.2015.09.019 [eCite] [Details]

Citations: Scopus - 55Web of Science - 55

Co-authors: King AE; Woodhouse A; Vickers JC

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2016Kirkcaldie MTK, Collins JM, 'The axon as a physical structure in health and acute trauma', Journal of Chemical Neuroanatomy, 76, (Part A) pp. 9-18. ISSN 0891-0618 (2016) [Refereed Article]

DOI: 10.1016/j.jchemneu.2016.05.006 [eCite] [Details]

Citations: Scopus - 9Web of Science - 9

Co-authors: Collins JM

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2016Vickers J, Mitew S, Woodhouse A, Fernandez-Martos CM, Kirkcaldie MT, et al., 'Defining the earliest pathological changes of Alzheimer's disease', Current Alzheimer research, 13, (3) pp. 281-287. ISSN 1567-2050 (2016) [Refereed Article]

DOI: 10.2174/1567205013666151218150322 [eCite] [Details]

Citations: Scopus - 20Web of Science - 19

Co-authors: Vickers J; Mitew S; Woodhouse A; Fernandez-Martos CM; Canty AJ; McCormack GH; King AE

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2016Vickers JC, Kirkcaldie MT, Phipps A, King AE, 'Alterations in neurofilaments and the transformation of the cytoskeleton in axons may provide insight into the aberrant neuronal changes of Alzheimer's disease', Brain Research Bulletin, 126, (Pt 3) pp. 324-333. ISSN 0361-9230 (2016) [Refereed Article]

DOI: 10.1016/j.brainresbull.2016.07.012 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

Co-authors: Vickers JC; Phipps A; King AE

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2015Collins JM, King AE, Woodhouse A, Kirkcaldie MTK, Vickers JC, 'The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease', Experimental Neurology, 267 pp. 219-29. ISSN 0014-4886 (2015) [Refereed Article]

DOI: 10.1016/j.expneurol.2015.02.034 [eCite] [Details]

Citations: Scopus - 22Web of Science - 23

Co-authors: Collins JM; King AE; Woodhouse A; Vickers JC

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2015Liu Y, Atkinson RAK, Fernandez-Martos CM, Kirkcaldie MTK, Cui H, et al., 'Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse', Neurobiology of Aging: Experimental and Clinical Research, 36, (2) pp. 1151-1159. ISSN 0197-4580 (2015) [Refereed Article]

DOI: 10.1016/j.neurobiolaging.2014.10.001 [eCite] [Details]

Citations: Scopus - 7Web of Science - 6

Co-authors: Liu Y; Atkinson RAK; Fernandez-Martos CM; Vickers JC; King AE

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2014Siedler DG, Chuah MI, Kirkcaldie MTK, Vickers JC, King AE, 'Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments', Frontiers in Cellular Neuroscience, 8 Article 429. ISSN 1662-5102 (2014) [Refereed Article]

DOI: 10.3389/fncel.2014.00429 [eCite] [Details]

Citations: Scopus - 55Web of Science - 47

Co-authors: Siedler DG; Chuah MI; Vickers JC; King AE

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2013Mitew S, Kirkcaldie MTK, Dickson TC, Vickers JC, 'Altered synapses and gliotransmission in Alzheimer's disease and AD model mice', Neurobiology of Aging, 34, (10) pp. 2341-2351. ISSN 0197-4580 (2013) [Refereed Article]

DOI: 10.1016/j.neurobiolaging.2013.04.010 [eCite] [Details]

Citations: Scopus - 75Web of Science - 74

Co-authors: Mitew S; Dickson TC; Vickers JC

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2013Mitew S, Kirkcaldie MTK, Dickson TC, Vickers JC, 'Neurites containing the neurofilament-triplet proteins are selectively vulnerable to cytoskeletal pathology in Alzheimer's disease and transgenic mouse models', Frontiers in Neuroanatomy, 7 Article 30. ISSN 1662-5129 (2013) [Refereed Article]

DOI: 10.3389/fnana.2013.00030 [eCite] [Details]

Citations: Scopus - 11Web of Science - 12

Co-authors: Mitew S; Dickson TC; Vickers JC

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2012Liu Yao, Staal JA, Canty AJ, Kirkcaldie MTK, King AE, et al., 'Cytoskeletal changes during development and aging in the cortex of neurofilament light protein knockout mice', The Journal of Comparative Neurology, 521, (8) pp. 1817-1827. ISSN 0021-9967 (2012) [Refereed Article]

DOI: 10.1002/cne.23261 [eCite] [Details]

Citations: Scopus - 10Web of Science - 9

Co-authors: Liu Yao; Staal JA; Canty AJ; King AE; Bibari O; Mitew ST; Dickson TC; Vickers JC

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2012Pankhurst MW, Gell DA, Butler CW, Kirkcaldie MTK, West AK, et al., 'Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury', Pl o S One, 7, (2) Article e31185. ISSN 1932-6203 (2012) [Refereed Article]

DOI: 10.1371/journal.pone.0031185 [eCite] [Details]

Citations: Scopus - 9Web of Science - 9

Co-authors: Pankhurst MW; Gell DA; Butler CW; West AK; Chung RS

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2011Pankhurst MW, Bennett W, Kirkcaldie MTK, West AK, Chung RS, 'Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice', Journal of Neuroinflammation, 8, (December) Article 172. ISSN 1742-2094 (2011) [Refereed Article]

DOI: 10.1186/1742-2094-8-172 [eCite] [Details]

Citations: Scopus - 12Web of Science - 13

Co-authors: Pankhurst MW; Bennett W; West AK; Chung RS

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2010Mitew S, Kirkcaldie MTK, Halliday G, Shepherd CE, Vickers JC, et al., 'Focal demyelination in Alzheimer's disease and transgenic mouse models', Acta Neuropathologica, 119, (5) pp. 567-577. ISSN 0001-6322 (2010) [Refereed Article]

DOI: 10.1007/s00401-010-0657-2 [eCite] [Details]

Citations: Scopus - 74Web of Science - 64

Co-authors: Mitew S; Vickers JC; Dickson TC

Tweet

2009Vickers JC, King AE, Woodhouse A, Kirkcaldie MT, Staal JA, et al., 'Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system ', Brain Research Bulletin, 80, (4-5) pp. 217-223. ISSN 0361-9230 (2009) [Refereed Article]

DOI: 10.1016/j.brainresbull.2009.08.004 [eCite] [Details]

Citations: Scopus - 45Web of Science - 44

Co-authors: Vickers JC; King AE; Woodhouse A; Staal JA; McCormack GH; Blizzard CA; Musgrove RE; Mitew S; Liu Y; Chuckowree JA; Bibari O; Dickson TC

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2008Chelvanayagam DK, Vickery RM, Kirkcaldie MTK, Coroneo MT, Morley JW, 'Multichannel surface recordings on the visual cortex: implications for a neuroprosthesis', Journal of Neural Engineering, 5, (2) pp. 125-132. ISSN 1741-2560 (2008) [Refereed Article]

DOI: 10.1088/1741-2560/5/2/003 [eCite] [Details]

Citations: Scopus - 9Web of Science - 7

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2007Kirkcaldie MTK, Kitchener PD, 'When brains expand: mind and the evolution of cortex', Acta Neuropsychiatrica, 19, (3) pp. 139-148. ISSN 0924-2708 (2007) [Refereed Article]

DOI: 10.1111/j.1601-5215.2007.00204.x [eCite] [Details]

Citations: Scopus - 11Web of Science - 10

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2007Saalmann YB, Kirkcaldie MTK, Waldron S, Calford MB, 'Cellular distribution of the GABAA receptor-modulating 3 α-hydroxy, 5 α-reduced pregnane steroids in the adult rat brain', Journal of Neuroendocrinology, 19, (4) pp. 272-284. ISSN 0953-8194 (2007) [Refereed Article]

DOI: 10.1111/j.1365-2826.2006.01527.x [eCite] [Details]

Citations: Scopus - 51Web of Science - 48

Co-authors: Calford MB

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2002Kirkcaldie MTK, Dickson TC, King CE, Grasby DJ, Riederer BM, et al., 'Neurofilament triplet proteins are restricted to a subset of neurons in the rat neocortex', Journal of Chemical Neuroanatomy, 24, (3) pp. 163-171. ISSN 0891-0618 (2002) [Refereed Article]

DOI: 10.1016/S0891-0618(02)00043-1 [eCite] [Details]

Citations: Scopus - 58Web of Science - 55

Co-authors: Dickson TC; King CE; Vickers JC

Tweet

1997Kirkcaldie MTK, Pridmore S, Pascual-Leone A, 'Transcranial magnetic stimulation as therapy for depression and other disorders', Australian and New Zealand Journal of Psychiatry, 31, (2) pp. 264-272. ISSN 0004-8674 (1997) [Refereed Article]

DOI: 10.3109/00048679709073830 [eCite] [Details]

Citations: Scopus - 42Web of Science - 41

Co-authors: Pridmore S

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1997Kirkcaldie MTK, Pridmore S, Reid P, 'Bridging the Skull: Electroconvulsive Therapy (ECT) and Repetitive Transcranial Magnetic Stimulation (rTMS) in Psychiatry', Convulsive Therapy, 13, (2) pp. 83-91. ISSN 0749-8055 (1997) [Refereed Article]

PMID: 9253528 [eCite] [Details]

Citations: Scopus - 16Web of Science - 17

Co-authors: Pridmore S

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Book

(2 outputs)
YearCitationAltmetrics
2010Watson CRR, Kirkcaldie MTK, Paxinos G, 'The Brain: An Introduction to Functional Neuroanatomy', Elsevier, Tokyo, pp. 215. ISBN 978-0-12-373889-9 (2010) [Authored Other Book]

[eCite] [Details]

2009Paxinos G, Watson C, Carrive P, Kirkcaldie MTK, Ashwell K, 'Chemoarchitectonic Atlas of the Rat Brain', Elsevier, USA, pp. 375. ISBN 978-0-12-374237-7 (2009) [Authored Research Book]

[eCite] [Details]

Chapter in Book

(3 outputs)
YearCitationAltmetrics
2017Watson C, Kirkcaldie M, Puelles L, 'Developmental gene expression redefines the mammalian brain stem', Evolution of Nervous Systems, Elsevier, JH Kass (ed), United Kingdom, pp. 467-475. ISBN 9780128040423 (2017) [Research Book Chapter]

DOI: 10.1016/B978-0-12-804042-3.00138-X [eCite] [Details]

Citations: Scopus - 4

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2013Hannan AJ, Kirkcaldie MTK, 'Constituents, organization and processes of the human brain', The Constitution of Visual Consciousness: Lessons from Binocular Rivalry. Advances in Consciousness Research, John Benjamins Publishing Company, SM Miller (ed), Amsterdam, pp. 15-35. ISBN 9789027213570 (2013) [Research Book Chapter]

[eCite] [Details]

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2011Kirkcaldie MTK, 'Neocortex', The Mouse Nervous System, Academic Press, C Watson, G Paxinos and L Puelles (ed), San Diego, pp. 52 - 111. ISBN 9780123694973 (2011) [Research Book Chapter]

DOI: 10.1016/B978-0-12-369497-3.10004-4 [eCite] [Details]

Citations: Scopus - 14

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Review

(1 outputs)
YearCitationAltmetrics
2017Kirkcaldie MTK, Dwyer ST, 'The third wave: Intermediate filaments in the maturing nervous system', Molecular and Cellular Neurosciences, 84 pp. 68-76. ISSN 1044-7431 (2017) [Substantial Review]

DOI: 10.1016/j.mcn.2017.05.010 [eCite] [Details]

Citations: Scopus - 9Web of Science - 8

Co-authors: Dwyer ST

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Conference Publication

(12 outputs)
YearCitationAltmetrics
2017Kirkcaldie MTK, Bindoff AD, Goldberg LM, Robinson AL, Vickers JC, 'Translating dementia knowledge to non-traditional settings and students', Alzheimer's Disease International (ADI), 26-29 April 2017, Kyoto, Japan (2017) [Conference Extract]

[eCite] [Details]

Co-authors: Bindoff AD; Goldberg LM; Robinson AL; Vickers JC

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2015Canty A, Carr A, Elliott K-E, Goldberg L, King C, et al., 'The Wicking Dementia Research and Education Centre - Paving the way forward in online dementia education', Teaching Matters 2014 - Places and Spaces, 2-3 December, 2014, Launceston, Tasmania, pp. 47. (2015) [Conference Extract]

[eCite] [Details]

Co-authors: Canty A; Carr A; Elliott K-E; Goldberg L; King C; McInerney F; Price A; Robinson A; Tolman J; Vickers J

2012King AE, Mitew S, Kirkcaldie MTK, Vickers JC, Dickson TC, 'Investigating the role of inhibition in neurological disease', 32nd Annual Meeting Australian Neuroscience Society, January 2012, Gold Coast, Australia (2012) [Conference Extract]

[eCite] [Details]

Co-authors: King AE; Mitew S; Vickers JC; Dickson TC

2012Kirkcaldie MTK, Watson C, Paxinos G, Franklin K, 'Straightening out the mouse neocortex', Australian Neuroscience Society Annual Conference, 29 Jan - 1 Feb, Gold Coast, QLD (2012) [Conference Extract]

[eCite] [Details]

2010Mitew S, Kirkcaldie MTK, Halliday GE, Shepherd CE, Vickers JC, et al., 'Focal demyelination in Alzheimer's disease and transgenic mouse models', Gordon Conference on Myelin, California (2010) [Conference Extract]

[eCite] [Details]

Co-authors: Mitew S; Vickers JC; Dickson TC

2009Dickson TC, King AE, Kirkcaldie MTK, Hosie K, Chung RS, et al., 'Novel alpha-internexin pathological alterations in both the spinal cord and brain of the G93A SOD1 model of amytrophic lateral sclerosis', Society for Neuroscience, 17-21 Oct, Chicago, pp. 304.13. (2009) [Conference Extract]

[eCite] [Details]

Co-authors: Dickson TC; King AE; Hosie K; Chung RS; Vickers JC

2009Dickson TC, King AE, Kirkcaldie MTK, Hosie K, Vickers JC, 'Novel alpha-internexin pathological alterations in both the spinal cord and forebrain of the G93A SOD1 model of Amyotrophic Lateral Sclerosis', Australian Society for Medical Research, 15-17 November, Hobart, Tasmania (2009) [Conference Extract]

[eCite] [Details]

Co-authors: Dickson TC; King AE; Hosie K; Vickers JC

2009Pankhurst MW, Chung RS, Kirkcaldie MTK, West AK, 'Peripheral effects of metallothionein in brain injury: Altered immune system response in metallothionein-1/2 null mice', Cell Stress Society International Abstracts, October, Sapporo, Japan (2009) [Conference Extract]

[eCite] [Details]

Co-authors: Pankhurst MW; Chung RS; West AK

1999Kirkcaldie MTK, Kitchener PD, Saunders NR, 'Cortical effects of capsaicin-induced peripheral fine-fibre deafferentation', Proceedings of the Australian Neuroscience Society, 31 Jan - 3 Feb, Hobart, pp. 178. ISSN 1034-3237 (1999) [Conference Extract]

[eCite] [Details]

Co-authors: Saunders NR

1997Kirkcaldie MTK, Pridmore S, Kitchener PD, 'Examining the physiological basis of clinical applications of transcranial magnetic stimulation', Proceedings of the Australian Neuroscience Society, Newcastle, pp. 181. (1997) [Conference Extract]

[eCite] [Details]

Co-authors: Pridmore S; Kitchener PD

1997Kitchener PD, Hutton EJ, Levaque LH, Kirkcaldie MTK, Dziegielewska KM, et al., 'Partial correlation between the numbers of fetuin-immunoreactive neurons and the levels of fetuin in plasma in the developing rat', Proceedings of the Australian Neuroscience Society, Newcastle, pp. 105. (1997) [Conference Extract]

[eCite] [Details]

Co-authors: Kitchener PD; Dziegielewska KM; Saunders NR

1997Pridmore S, Kirkcaldie MTK, Couper DJ, 'Transcranial magnetic stimulation (TMS) in melancholic dexamethasone suppression test (DST) positive patients', The Royal Australian and New Zealand College of Psychiatrists 32nd Congress, Sydney, pp. 12. (1997) [Conference Extract]

[eCite] [Details]

Co-authors: Pridmore S; Couper DJ

Grants & Funding

Funding Summary

Number of grants

5

Total funding

$698,829

Projects

PhD top-up - Ellie Bucher (2019 - 2021)$30,000
Description
Project title: Excitatory-Inhibitory relationships in cerebral cortex affected by the pathology of Alzheimer's disease'.
Funding
The Yulgilbar Foundation ($30,000)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
King AE; Kirkcaldie MTK; Bucher EA
Period
2019 - 2021
Staying connected: determining targets to protect neuronal circuitry in ALS (2017)$97,119
Description
Amyotrophic lateral sclerosis (ALS) is characterized by degeneration and loss of nerve cell processes. The resulting loss of connectivity is likely to be the key contributor to the clinical symptoms of disease and is evident from the substantial axonal pathology present. In this project we will investigate mechanisms of axonopathy resulting from pathologic TDP-43, a key contributor to disease. We will utilize a novel of of axon degeneration in the cisual system which allows us to directly probe changes in the axon.
Funding
Motor Neurone Disease Research Institute of Australia Inc ($97,119)
Scheme
Grant-In-Aid
Administered By
University of Tasmania
Research Team
King AE; Kirkcaldie MTK
Year
2017
Does plasticity drive Alzheimers disease and can sleep help (2017)$94,140
Description
This study seeks to elucidate a potential causal mechanism for Alzheimers disease: that plasticity drives disease pathology, and that sleep compensates for these effects of plasticity in a manner which declines with age. The study will manipulate levels of cortical plasticity and the duration of sleep in a transgenic rodent model, the APP/PS1 mouse, and track the resulting development of pathology.
Funding
The Mason Foundation ($94,140)
Scheme
Grant-Judith Jane Mason & Harold Stannett Williams
Administered By
University of Tasmania
Research Team
Kirkcaldie MTK; King AE; Vickers JC
Year
2017
Paving the way for future stroke drug development: creating new gold-standard model of stroke (2017 - 2019)$442,570
Description
Stroke is a leading cause of death and chronic disability. Stroke therapeutics developed in animal models fail when translated into human clinical trials, due to flaws inherent in these models. We will break through this translational roadblock by using magnetic microparticles to induce an ischemic stroke that accurately represents human disease
Funding
Royal Hobart Hospital Research Foundation ($442,570)
Scheme
Grant - Project Grant Funding
Administered By
University of Tasmania
Research Team
Landowski LM; Howells DW; Castley H; Sutherland BA; Kirkcaldie MTK
Period
2017 - 2019
A mouse model of mild maternal iodine deficiency and its effect on brain structure (2016)$35,000
Description
Establishinga mouse model of mild gestationaliodine deficiency to study its effects on brain structure and function.
Funding
Brain Foundation ($35,000)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Kirkcaldie MTK; King AE; Vickers JC; Burgess JR; Hynes K
Year
2016

Research Supervision

Dr Kirkcaldie has supervised several Honours and PhD candidates to successful completion in projects relating to brain pathology and brain injury. He currently supervises both PhD and research Master's students. Matthew is very enthusiastic scientist who is currently looking for more students, please contact him to discuss potential projects.

Current

6

Completed

5

Current

DegreeTitleCommenced
PhDCharacterisation and Comparison of Rodent Models of Alzheimers Disease2014
PhDOligodendrocyte Dysfunction in Dementia2016
PhDInvestigating Microglia's Role in the Pathology of Alzheimer's Disease2018
PhDExcitatory-Inhibitory Relationships in Cerebral Cortex Affected by the Pathology of Alzheimer's Disease2018
PhDThe Role of Wallerian Degeneration and Axon Loss in Dementia2019
PhDEarly Detection of Dementia Using Testing Tools in VR/AR Environment2019

Completed

DegreeTitleCompleted
MastersSleep Pattern and Physiological Markers of Stress in Graduate Paramedics
Candidate: Jason Betson
2019
PhDFrontotemporal Dementia and Amyotrophic Lateral Sclerosis Proteins in Neurite Health and Dysfunction
Candidate: Rachel Alice Kathryn Atkinson
2018
PhDThe Effect of Traumatic Brain Injury in Experimental Models of Alzheimers Disease
Candidate: Jessica Marie Collins
2016
PhDAxonal and Synaptic Pathology in Alzheimer's Disease
Candidate: Stanislaw Mitew
2013
PhDImmune System Modulation in the Brain Injury of the Metallothionein-I/II null Mutant Mouse
Candidate: Michael William Pankhurst
2011