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Roslyn Malley

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Roslyn Malley

Lecturer Medical Sciences

Room 306-14 (Level 3) , Medical Science 1

+61 3 6226 4753 (phone)

+61 3 6226 4788 (fax)

Roslyn.Malley@utas.edu.au

Biography

Dr Malley completed her MBBS at the University of Tasmania in 1999. She was an intern at the Royal Hobart Hospital in 2000. After a year of travelling abroad she returned to the Royal Hobart Hospital as a Registered Medical Officer.

Dr Malley then commenced a Fellowship in Pathology as a Pathology Registrar and, as part of the training program, she has undertaken a PhD in the field of immunology.

Teaching

Teaching responsibility

Dr Malley co-ordinates the Pathology teaching in the 5 year Medical Course. With the strong support of the Royal Hobart Hospital Pathology staff they deliver a lecture, tutorial and practical program that includes Anatomical Pathology, Clinical Chemistry, Haematology Immunology and Microbiology.

She largely teaches Anatomical Pathology in the second year medical program.

Their overall aim is to ensure students have a strong knowledge of pathology in order to recognise and manage disease and to order and interpret pathology investigations appropriately throughout their medical careers.

Units taught:

View more on Dr Roslyn Malley in WARP

Research Themes

Dr Malley's research aligns with the university's research theme of Better Health.

The Cancer and Immunology Group has broad interests in how the immune system may be altered to allow malignant cells – cancer cells – to escape detection and destruction by the immune system.

Dr Malley's PhD investigated the influence of dietary vitamin D on the skin immune system and the skin's response to ultraviolet B irradiation – the component of sunlight that causes vitamin D production in the skin but also skin cancer.

Their overall aim is to contribute to the understanding of how the immune system is altered to allow cancers to escape an immune response. The Group further wishes to understand how they can prevent or reverse these changes in the immune system in order to prevent and treat cancer.

Fields of Research

  • Cellular immunology (320404)
  • Tumour immunology (320409)
  • Medical bacteriology (320701)
  • Cancer genetics (321103)
  • Medicine, nursing and health curriculum and pedagogy (390110)
  • Animal immunology (310905)
  • Preventative health care (420605)
  • Haematology (320102)
  • Molecular targets (321108)
  • Autoimmunity (320403)
  • Medical virology (320705)
  • Immunology (320499)
  • Solid tumours (321111)
  • Innate immunity (320407)
  • Oncology and carcinogenesis (321199)

Research Objectives

  • Clinical health (200199)
  • Other health (209999)
  • Assessment, development and evaluation of curriculum (160301)
  • Preventive medicine (200412)
  • Terrestrial biodiversity (180606)
  • Diagnosis of human diseases and conditions (200101)

Publications

Total publications

32

Journal Article

(12 outputs)
YearCitationAltmetrics
2020Choi-Lundberg DL, Al-Aubaidy HAM, Burgess J, Clifford CA, Cuellar WA, et al., 'Minimal effects of reduced teaching hours on undergraduate medical student learning outcomes and course evaluations', Medical Teacher, 42, (1) pp. 58-65. ISSN 0142-159X (2020) [Refereed Article]

DOI: 10.1080/0142159X.2019.1652258 [eCite] [Details]

Citations: Scopus - 5Web of Science - 6

Co-authors: Choi-Lundberg DL; Al-Aubaidy HAM; Burgess J; Clifford CA; Cuellar WA; Errey JA; Harper AJ; Ross RM; Williams A-MM; Hays R

Tweet

2020Wilkinson EJ, Woodworth AM, Parker M, Phillips JL, Malley RC, et al., 'Epigenetic regulation of the ITGB4 gene in prostate cancer', Experimental Cell Research, 392, (2) pp. 1-10. ISSN 0014-4827 (2020) [Refereed Article]

DOI: 10.1016/j.yexcr.2020.112055 [eCite] [Details]

Co-authors: Wilkinson EJ; Woodworth AM; Parker M; Phillips JL; Dickinson JL; Holloway AF

Tweet

2019See-Too WS, Ambrose M, Malley R, Ee R, Mulcahy E, et al., 'Pandoraea fibrosis sp. nov., a novel Pandoraea species isolated from clinical respiratory samples', International Journal of Systematic and Evolutionary Microbiology, 69, (3) pp. 645-651. ISSN 1466-5026 (2019) [Refereed Article]

DOI: 10.1099/ijsem.0.003147 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

Co-authors: Ambrose M; Mulcahy E; Roddam LF

Tweet

2017FitzGerald LM, Raspin K, Marthick JR, Field MA, Malley RC, et al., 'Impact of the G84E variant on HOXB13 gene and protein expression in formalin-fixed, paraffin-embedded prostate tumours', Scientific Reports, 7, (1) Article 17778. ISSN 2045-2322 (2017) [Refereed Article]

DOI: 10.1038/s41598-017-18217-w [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: FitzGerald LM; Raspin K; Marthick JR; Blackburn NB; Banks A; Charlesworth JC; Dickinson JL

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2017Tovar C, Pye RJ, Kreiss A, Cheng Y, Brown GK, et al., 'Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils', Scientific Reports, 7 Article 43827. ISSN 2045-2322 (2017) [Refereed Article]

DOI: 10.1038/srep43827 [eCite] [Details]

Citations: Scopus - 30Web of Science - 30

Co-authors: Tovar C; Pye RJ; Kreiss A; Brown GK; Darby J; Lyons AB; Woods GM

Tweet

2016Ambrose M, Malley RC, Warren SJ, Beggs SA, Swallow OFE, et al., 'Pandoraea pnomenusa isolated from an Australian patient with cystic fibrosis', Frontiers in microbiology, 7 Article 692. ISSN 1664-302X (2016) [Refereed Article]

DOI: 10.3389/fmicb.2016.00692 [eCite] [Details]

Citations: Scopus - 5Web of Science - 6

Co-authors: Ambrose M; Beggs SA; Roddam LF

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2013Malley RC, Muller HK, Norval M, Woods GM, 'Dietary vitamin D alters the response of the skin to UVB-irradiation depending on the genetic background of the mice', Photochemical & Photobiological Sciences, 12 pp. 536-545. ISSN 1474-9092 (2013) [Refereed Article]

DOI: 10.1039/c2pp25211b [eCite] [Details]

Citations: Scopus - 11Web of Science - 8

Co-authors: Muller HK; Woods GM

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2011McGee HM, Malley RC, Muller HK, Woods GM, 'Neonatal exposure to UVR alters skin immune system development, and suppresses immunity in adulthood', Immunology and Cell Biology, 89, (7) pp. 767-776. ISSN 0818-9641 (2011) [Refereed Article]

DOI: 10.1038/icb.2010.170 [eCite] [Details]

Citations: Scopus - 10Web of Science - 10

Co-authors: McGee HM; Muller HK; Woods GM

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2009Malley RC, Muller HK, Norval M, Woods GM, 'Vitamin D3 deficiency enhances contact hypersensitivity in male but not in female mice ', Cellular Immunology, 255, (1-2) pp. 33-40. ISSN 0008-8749 (2009) [Refereed Article]

DOI: 10.1016/j.cellimm.2008.09.004 [eCite] [Details]

Citations: Scopus - 12Web of Science - 11

Co-authors: Muller HK; Woods GM

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2008Muller HK, Malley RC, McGee HM, Scott DK, Wozniak T, et al., 'Effect of UV Radiation on the Neonatal Skin Immune System - Implicaions for Melanoma', Photochemistry and Photobiology, 84, (1) pp. 47-54. ISSN 0031-8655 (2008) [Refereed Article]

DOI: 10.1111/j.1751-1097.2007.00246.x [eCite] [Details]

Citations: Scopus - 21Web of Science - 20

Co-authors: Muller HK; McGee HM; Scott DK; Woods GM

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2007Scott DK, Lord R, Muller HK, Malley RC, Woods GM, 'Proteomics identifies enhanced expression of stefin A in neonatal murine skin compared with adults: functional implications', British Journal of Dermatology, 156, (6) pp. 1156-1162. ISSN 0007-0963 (2007) [Refereed Article]

DOI: 10.1111/j.1365-2133.2007.07875.x [eCite] [Details]

Citations: Scopus - 17Web of Science - 18

Co-authors: Scott DK; Lord R; Muller HK; Woods GM

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2000Woods GM, Doherty KV, Malley RC, Rist MJ, Muller HK, 'Carcinogen-modified dendritic cells induce immunosuppression by incomplete T-cell activation resulting from impaired antigen uptake and reduced CD86 expression', Immunology, 99, (1) pp. 16-22. ISSN 0019-2805 (2000) [Refereed Article]

DOI: 10.1046/j.1365-2567.2000.00928.x [eCite] [Details]

Citations: Scopus - 15Web of Science - 17

Co-authors: Woods GM; Doherty KV; Muller HK

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Review

(6 outputs)
YearCitationAltmetrics
2008Muller HK, Malley RC, McGee HM, Scott DK, Wozniak T, et al., 'Effect of UV Radiation on the Neonatal Skin Immune System- Implications for Melanoma', Photochemistry and Photobiology, 94, (1) pp. 47-54. (2008) [Review Several Works]

DOI: 10.1111/j.1751-1097.2007.00246.x [eCite] [Details]

Co-authors: Muller HK; McGee HM; Scott DK; Woods GM

Tweet

2008Norval M, Malley RC, Woods GM, 'What's new in photoimmunology?', Photodermatology, Photoimmunology & Photomedicine, 24, (6) pp. 334-336. (2008) [Review Several Works]

[eCite] [Details]

Co-authors: Woods GM

2007Norval M, Malley RC, Woods GM, 'What's new in photoimmunology?', Photodermatology, Photoimmunology & Photomedicine, 23 pp. 148-151. (2007) [Review Several Works]

[eCite] [Details]

Co-authors: Woods GM

2007Norval M, Malley RC, Woods GM, 'Immune protection against photocarcinogenesis', Expert Review of Dermatology, 2, (5) pp. 1507-1515. (2007) [Substantial Review]

[eCite] [Details]

Co-authors: Woods GM

2005Norval M, Malley RC, Woods GM, 'What's new in photoimmunology', Photodermatology, Photoimmunology and Photomedicine, 21, (5) pp. 267-269. (2005) [Review Several Works]

[eCite] [Details]

Co-authors: Woods GM

2005Woods GM, Malley RC, Muller HK, 'The skin immune system and the challenge of tumour immunosurveillance', European Journal of Dermatology, 157, (2) pp. 63-69. (2005) [Substantial Review]

[eCite] [Details]

Co-authors: Woods GM; Muller HK

Conference Publication

(14 outputs)
YearCitationAltmetrics
2014Sharma A, Batt T, Malley RC, Tegg EM, Johnston AM, 'HIT- Are we doing it right ? An audit of Heparin-induced thrombocytopenia testing at Royal Hobart Hospital', Annaul Scientific meeting HAA 2014, 19-22 October, 2014, Perth, Australia (2014) [Conference Extract]

[eCite] [Details]

Co-authors: Sharma A; Tegg EM; Johnston AM

2010Malley RC, Assenheimer D, Chapman JA, Choi-Lundberg DL, Williams A-MM, 'Cadaver path: Integration of anatomy and anatomical pathology in the dissection laboratory', Australian & New Zealand Association of Clinical Anatomists, December 2010, Hobart, TAS (2010) [Conference Extract]

[eCite] [Details]

Co-authors: Assenheimer D; Chapman JA; Choi-Lundberg DL; Williams A-MM

2010Malley RC, Muller HK, Norval M, Woods GM, 'Vitamin D3, the skin immune system and cutaneous carcinogenesis', Report of the National Institute of Water and Atmospheric Research (NIWA) UV Workshop, 7-9 May, Queenstown, New Zealand, pp. 51. (2010) [Non Refereed Conference Paper]

[eCite] [Details]

Co-authors: Muller HK; Woods GM

2010Malley RC, Muller HK, Woods GM, 'Vitamin D3 influences skin draining lymph node dendritic cells in neonatal male mice', National Health and Medical Research Congress, Melbourne, pp. 398. (2010) [Conference Extract]

[eCite] [Details]

Co-authors: Muller HK; Woods GM

2009Malley RC, Muller HK, Woods GM, 'Dietary vitamin D3 protects against UVB-induced immunosuppression in C57BL/6, but not BALB/c mice', MEPSA Conference, Sydney (2009) [Conference Extract]

[eCite] [Details]

Co-authors: Muller HK; Woods GM

2008Malley RC, Muller HK, Woods GM, 'Vitamin D3 nutrition influences regulatory T cell induction in neonatal tolerance and adult immunity', MEPSA Conference, December, Brisbane (2008) [Conference Extract]

[eCite] [Details]

Co-authors: Muller HK; Woods GM

2007Malley RC, Muller HK, Woods GM, 'Dietary vitamin D3 influences UVB induced DNA damage and immunosuppression', Mutagenesis and Experimental Pathology of Australasia Conference, Hobart (2007) [Conference Extract]

[eCite] [Details]

Co-authors: Muller HK; Woods GM

2007Malley RC, Muller HK, Woods GM, 'Vitamin D promotes neonatal tolerance induction to contact sensitisers', Australasian Society for Immunology Meeting, Sydney (2007) [Conference Extract]

[eCite] [Details]

Co-authors: Muller HK; Woods GM

2006Dharmadasa T, Malley RC, Muller HK, Woods GM, 'Dietary Vitamin D3 deficiency alters skin UVB-induced DNA damage in neonatal mice', Proceedings of the Australian Health and Medical Research Congress 2006, November, 2006, Melbourne, Victoria, pp. 466. (2006) [Conference Extract]

[eCite] [Details]

Co-authors: Muller HK; Woods GM

2006Malley RC, Muller HK, Woods GM, 'Modification of skin immune system function by dietary vitamin D3 is influenced by age and gender', Proceedings of the Australian Health and Medical Research Congress 2006, November, 2006, Melbourne, Victoria, pp. 218. (2006) [Conference Extract]

[eCite] [Details]

Co-authors: Muller HK; Woods GM

2005Malley RC, Muller HK, Woods GM, 'Vitamin D deficiency alters the contact sensitivity response in BALB/c mice', Tissue Antigens, November, 2005, Melbourne, Victoria, pp. 486. ISSN 0001-2815 (2005) [Conference Extract]

[eCite] [Details]

Co-authors: Muller HK; Woods GM

1998Muller HK, Malley RC, Woods GM, 'Alterations of Langerhans cell function during the early stages of cutaneous carcinogenesis confers immunosuppression rather than immunity', Journal of Investigative Dermatology, 7-10 May, Cologne, Germany, pp. 565. (1998) [Conference Extract]

[eCite] [Details]

Co-authors: Muller HK; Woods GM

1997Malley RC, Muller HK, Woods GM, 'Reduced dendritic cell function during the early stages of chemical carcinogenesis', 27th Annual Meeting of the Australasian Society for Immunology, Perth, pp. 68. (1997) [Conference Extract]

[eCite] [Details]

Co-authors: Muller HK; Woods GM

1997Malley RC, Woods GM, Muller HK, 'Langerhans cell function during the early stages of carcinogenesis', 5th International Workshop on Langerhans cells, Salzburg, Vienna, pp. 268. (1997) [Conference Extract]

[eCite] [Details]

Co-authors: Woods GM; Muller HK

Grants & Funding

Funding Summary

Number of grants

8

Total funding

$200,642

Projects

Is EEF2 a potential biomarker for more aggressive prostate cancer in Tasmanian patients? (2019)$23,906
Description
A recent study suggests that higher EEF2 levels are associated with more aggressive prostate cancer, however these results are yet to be validated. We aim to validate these results in our Tasmanian prostate cancer resource and determine if higher EEF2 levels are caused by DNA abnormalities in the tumour.
Funding
Royal Hobart Hospital Research Foundation ($23,906)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Fitzgerald LM; Dickinson JL; Murdolo V; Donovan S; Malley RC; Redwig F
Year
2019
A Clinical and Biospecimens Prostate Cancer Resource for Biomarker Research in Tasmania (2018)$22,146
Description
We propose to build upon the clinically-focused Prostate Cancer Outcomes Registry, Tasmania (PCOR-TAS) and collect matched biological samples to create a valuable resource for both clinicians and scientists. The availability of clinical and genetic data will allow important biomarker research into predicting prostate cancer outcomes and improving treatment strategies.
Funding
Royal Hobart Hospital Research Foundation ($22,146)
Scheme
Grant-Minor Project
Administered By
University of Tasmania
Research Team
Fitzgerald LM; Dickinson JL; Skala M; Stokes BC; Donovan S; Malley RC; Redwig F; Holloway AF; Taberlay PC
Year
2018
Investigation of chromosomal loss and gain at 7p21 in a Tasmanian hereditary prostate cancer family (2017)$23,186
Description
This project aims to fine-map and determine the underlying cause of chromosomal loss and gain at 7p21 in a Tasmanian hereditary prostate cancer family. This region contains a candidate gene, ETV1, which is known to be translocated in ~7% of tumours and increases the invasive and metastatic potential of tumours. Emerging therapies targeting this translocation could improve outcomes in Tasmanian men with prostate cancer.
Funding
Royal Hobart Hospital Research Foundation ($23,186)
Scheme
Grant-Establishment
Administered By
University of Tasmania
Research Team
Fitzgerald LM; Dickinson JL; Malley RC; Donovan S; Dun Karen; Diano G; Skala M; Redwig F
Year
2017
Non-conventional antimicrobial testing of emerging pathogens (2017)$10,000
Description
Pandoraea, is an emerging bacterial pathogen of cystic fibrosis. Conventional antibiotic susceptibility testing shows Pandoraea to be multi-drug resistant with limited treatment options. We will investigate the antibiotic susceptibility of Pandoraea using non-conventional methods to determine if we are underestimating treatment options for this chronic infection.
Funding
Royal Hobart Hospital Research Foundation ($10,000)
Scheme
Grant-Starter
Administered By
University of Tasmania
Research Team
Roddam LF; Beggs S; Ambrose M; Malley RC
Year
2017
Prevalence and virulence of an emerging bacterial pathogen of Tasmanian cystic fibrosis patients (2015)$11,100
Description
Pandoraea, an emerging bacterial pathogen of cystic fibrosis is difficult to identify, is of unknown clinical significance and was recently isolated from a Tasmanian CF patient. we will investigate the prevalence of Pandoraea in Tasmanian CF patients, describe its virulence potential and investigate its susceptilility to our new antimicrobial therapy.
Funding
Royal Hobart Hospital Research Foundation ($11,100)
Scheme
Grant-Clinical Research
Administered By
University of Tasmania
Research Team
Roddam LF; Ambrose M; Beggs S; Cooley MA; Malley RC; Warren Sanchia; Wilson RR; McEwan B
Year
2015
Sex differences in Regulatory T cell Development and Function in NeonatalTolerance (2011)$23,409
Funding
University of Tasmania ($23,409)
Scheme
Grant-Institutional Research Scheme
Administered By
University of Tasmania
Research Team
Malley RC; McGee HM
Year
2011
The Skin Immune System in Cutaneous Carcinogenesis (2005 - 2007)$74,895
Funding
National Health & Medical Research Council ($74,895)
Scheme
Scholarship-Postgraduate:Medical
Administered By
University of Tasmania
Research Team
Woods GM; Malley RC
Period
2005 - 2007
Grant Reference
352624
Vitamin D Deficiency in Skin Cancer Development (2005)$12,000
Funding
Royal Hobart Hospital Research Foundation ($12,000)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Woods GM; Muller HK; Malley RC
Year
2005