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Stephen Myers

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Stephen Myers

Stephen Myers

Lecturer in Laboratory Medicine
Health Sciences (School of )

Room 111, C, Launceston CBD Campuses

(03) 6324 5459 (phone)

(03) 6324 3995 (fax)

Stephen.Myers@utas.edu.au

Type 2 diabetes is a major and common disease that will affect an estimated 90,000 Tasmanians by 2033. It becomes more severe through a person’s lifetime and can lead to heart attacks, amputations, strokes and blindness.

Insulin resistance is a precursor to type 2 diabetes. Insulin resistance is typically present for several years before type 2 diabetes diagnosis and progression. Currently people with insulin resistance can take a range of medications, which, while effective, can have unpleasant side-effects. Therefore, prevention strategies that take advantage of this ‘window of opportunity’ to prevent or lessen disease progression would have a significant health impact for people with this disorder.

University of Tasmania medical researcher Dr Stephen Myers is working with a team of researchers to understand the role of zinc in insulin resistance. Dr Myers and his team of PhD students and surgeons at Launceston General Hospital have made some unique findings that are generating interest on an international level.

‘We’ve been collecting samples of skeletal muscle tissue from patients with type 2 diabetes who are undergoing hip and knee replacements. Skeletal muscle is highly important as it is the major tissue that takes up glucose. We’ve found some fascinating results when it comes to zinc transporters – these are proteins that enable glucose within cells to be converted to energy more efficiently,’ says Dr Myers.

‘We’re the first to show that zinc targets specific proteins in a cell that are essential for getting glucose into cells. We’ve also found that zinc and the zinc transporters are compromised in insulin resistance. Zinc is found in our foods and is therefore natural – it will be a significant finding if we can use zinc to treat insulin resistance.

‘Research can sometimes feel very focused, for example when you’re looking at samples, analysing data or reading through huge numbers of research papers; however, it’s also very collaborative in our research team. We know that we’re part of a global effort to understand type 2 diabetes. I think of us as a Tasmanian research group with global outreach.’

Dr Myers says, ‘I’m motivated by seeing other researchers use ideas from our research to develop specific studies to expand their knowledge. It’s rewarding to know I’m part of a huge global effort that can lead to the therapeutic discovery that will go on to clinical trials and, hopefully, breakthrough treatments.’

Dr Myers is fascinated by type 2 diabetes because researchers still don’t understand the molecular factors that lead to a person’s body not responding to insulin – this means glucose doesn’t enter cells and the body can’t use energy.

‘My work, like most research work, has elements that are time-consuming and difficult, but then there are wonderful moments of serendipity when something totally unexpected comes out of the research. I enjoy those moments when a PhD student comes to share their data and they have a twinkle in their eye because they’ve done something well or discovered something.

‘I hope to find a way to ensure that fewer people develop type 2 diabetes. If we can understand the role of zinc and zinc transporters in insulin resistance, we might be able to therapeutically target these factors or modify existing diet and lifestyle so that people never develop insulin resistance or develop type 2 diabetes.’

This would mean, in Tasmania alone, we would see a significant decline in diabetes and associated secondary disabilities and diseases, including amputations, stroke, heart attack, kidney disease and blindness.

Dr Steve Myers is an experienced lecturer and researcher in the medical sciences. He is interested in aspects of metabolic disease and specifically insulin resistance and type 2 diabetes. Steve has previously worked in a number of academic institutes including. The University of Queensland, Queensland University of Technology, University of the Sunshine Coast, and Federation University Australia. Since moving to Tasmania in 2015, Steve has combined his expertise in metabolic disease with the School's Exercise and Nutritional Sciences and laboratory medicine.

Biography

Steve completed his PhD studies in 2004 at Queensland University of Technology where he was the recipient of an NHMRC 'Dora Lush' postgraduate scholarship to study steroid hormones and cancer. He continued with a Post-doctoral position at The University of Queensland in the field of nuclear receptors and metabolic disease. Steve then moved to Victoria, Australia where he was the recipient of a Collaborative Research Network Fellowship to undergo studies into zinc transporters and insulin resistance. Steve also has a strong interest environmental science and coastal systems and the impact of environmental change on health processes. He is now establishing his research portfolio within the School of Health Sciences, College of Health and Medicine, University of Tasmania.

Career summary

Qualifications

  • PhD, Hormonal regulation of kallikrein genes in human cancer, Queensland University of Technology, Australia, 2004.
  • Master of Environmental Science, University of Newcastle, Australia, 2011.
  • BAppSci (Honours 1st Class), Estrogen and progesterone regulation of the kallikrein 4 gene in endometrial cancer, Queensland University of Technology, Australia, 2001.
  • BAppSci (majoring in molecular biology/biochemistry), Queensland University of Technology, Australia, 2000.

Languages (other than English)

Bahasa Indonesian, Bahasa Malaysian

Memberships

Professional practice

  • Internationalisation Committee (UTAS)
  • Institutional Biosafety Committee
  • The Australian Society for Medical Research (ASMR) Tasmania Committee
  • The Simulation Committee, (UTAS)
  • Endocrine Society of Australia
  • The Australian Society for Medical Research
  • Zinc-net UK
  • Reviewer for Applied Physiology, DARU Journal of Pharmaceutical Sciences, Journal of Diabetes and Metabolism, Current Diabetes Reviews, International Journal of Biochemistry and Cellular Biology, Diabetes and Metabolism

Teaching

Cell and Molecular biochemistry, Metabolic Biochemistry, Human Molecular Biology, Genetics Bioinformatics

Teaching expertise

Steve has over ten years of university teaching and has extensive experience in the preparation, assessment and delivery of courses, lectures and training programs in Cell and Molecular Biology, Biochemistry, Human Genetics, Bioinformatics, and Bioethics to a diverse audience including university, domestic, and international students, industry and secondary schools.

Teaching responsibility

Steve is responsible for teaching in the School of Health Sciences and is the unit coordinator for Metabolic Biochemistry (CXA261), Cell and Molecular Biology (CXA262) and Human Molecular Biology (CXA300). He has experience in both undergraduate and postgraduate teaching to students studying the medical-based sciences.

Research Invitations

  • Invited speaker, BITs 3rd Annual World Congress of Endobolism: May 20-23 China (Xi'an) 2013
  • Invited speaker: Exploring the Links Between Diabetes and Dementia, October, 2015, Westbury Tasmania
  • Invited speaker: Australian Institute of Medical Sciences (AIMS), July 2015, Cradle Mountain, Tasmania
  • Rural Health Symposium, Penny Royal Launceston, September 2018

View more on Dr Stephen Myers in WARP

Expertise

Steve has a broad interest in metabolic disease with a particular focus on insulin resistance and zinc transporters in skeletal muscle. Insulin resistance is of major global concern because it is increasingly implicated in the development of type 2 diabetes (T2D), heart disease, hypertension, obesity, and stroke. Steve's research has shown an exciting role for the physiological importance of zinc and the proteins that transport zinc in cells, in diseases associated with abnormal cellular signalling and metabolism, such as insulin resistance.

Research Themes

Steve's research aligns with the University's research of Better Health. His research interests include understanding the molecular mechanisms of zinc transporters and insulin resistance in skeletal muscle and also the impact of nutritional processes that facilitate better health outcomes for type 2 diabetes. Steve is also interested in community outreach and volunteer programs that fosters stewardship towards better health and wellbeing. He is also collaborating with several researchers at UTAS on a number of projects including:

  • Impact and molecular mechanisms of cellular transitions in lung cancers in smokers
  • Exercise training and improvement of type 2 diabetes

Collaboration

  1. Professor George Muscat, Institute for Molecular Biosciences, The University of Queensland, Brisbane, Australia.
  2. Associate Professor Mark Myers, School of health Sciences, University of Ballarat, VIC Australia.
  3. Dr Tony Cook and Dr Rajaraman Eri, School of Human Life Sciences, University of Tasmania, Newnham Campus, Launceston.
  4. Associate Professor William Wong, Department of Physiology, Johns Hopkins University School of Medicine Medical, Baltimore USA.
  5. Dr Sukhwinder Sohal, University of Tasmania, School of Health Sciences
  6. Professor Steve Rattigan, Menzies Institute for Medical Research, University of Tasmania
  7. Dr Hayder Al-Aubaidy, Faculty of Health, University of Tasmania
  8. Dr Sam Wu and Dr Andy Williamson, Exercise Sciences, University of Tasmania

Awards

  • National Health and Medical Research Council (NHMRC) Postgraduate (PhD) Scholarship (Dora Lush), 2000-2004.
  • University of Queensland Post-doctoral Fellowship Award, Brisbane, 2006-2009.
  • Early Career Research Grant: The University of Queensland, 2008-2009.
  • Associate Investigator: NHMRC Research Grant, Institute for Molecular Biosciences, University of Queensland, 2009-2011
  • CSIRO Postdoctoral Fellowship, University of the Sunshine Coast, Queensland, 2010-2011.
  • Collaborative Research Network Fellowship 2011-2014, Federation University Australia, Victoria, 3350.
  • Invited speaker, BITs 3rd Annual World Congress of Endobolism: May 20-23 China (Xi'an) 2013
  • Honorary Research Fellow Appointment, Federation University Australia, 2014-2017.
  • Career Development Scholarship, UTAS, Launceston 2015
  • Clifford Craig Medical Research Trust Award, UTAS, Launceston 2016-2019

Current projects

Exploring zinc to improve insulin sensitivity and glucose metabolism in human insulin-resistant skeletal muscle (Funded by the Clifford Craig Medical Research Trust)

https://cliffordcraig.org.au/clifford-craig-foundation-grant-to-study-zinc-and-insulin-resistance-in-type-2-diabetes/

Fields of Research

  • Cell Metabolism (060104)
  • Respiratory Diseases (110203)
  • Signal Transduction (060111)
  • Receptors and Membrane Biology (060110)
  • Environmental Management (050205)
  • Exercise Physiology (110602)
  • Genomics (060408)
  • Enzymes (060107)
  • Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) (060106)
  • Genome Structure and Regulation (060407)
  • Analytical Biochemistry (060101)
  • Health, Clinical and Counselling Psychology (170106)
  • Environmental Education and Extension (050203)
  • Bioinformatics (060102)
  • Dietetics and Nutrigenomics (111102)
  • Cell Physiology (111601)
  • Gene Expression (incl. Microarray and other genome-wide approaches) (060405)
  • Health Policy (160508)
  • Ecological Impacts of Climate Change (050101)
  • Neurosciences (110999)
  • Cardiology (incl. Cardiovascular Diseases) (110201)
  • Peripheral Nervous System (110905)
  • Complementary and Alternative Medicine (110499)
  • Clinical Nursing: Primary (Preventative) (111002)
  • Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) (110106)

Research Objectives

  • Diabetes (920104)
  • Respiratory System and Diseases (incl. Asthma) (920115)
  • Cancer and Related Disorders (920102)
  • Climate Change Adaptation Measures (960301)
  • Carer Health (920202)
  • Reproductive System and Disorders (920114)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Skeletal System and Disorders (incl. Arthritis) (920116)
  • Ecosystem Adaptation to Climate Change (960305)
  • Expanding Knowledge in the Biological Sciences (970106)
  • Endocrine Organs and Diseases (excl. Diabetes) (920106)
  • Digestive System Disorders (920105)
  • Coastal and Estuarine Water Management (960903)
  • Cardiovascular System and Diseases (920103)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Health Education and Promotion (920205)
  • Allied Health Therapies (excl. Mental Health Services) (920201)
  • Nervous System and Disorders (920111)
  • Preventive Medicine (920412)

Publications

Steve has published 54 peer-reviewed journal articles and book chapters and has an H-index of 19 and has 1275 citations. His 2014 paper 'Nutrition, Genes and Modern Disease: A Current Dilemma or a Legacy of our Past' published in the Journal of Diabetes and Metabolism has a total of 12114 views

Total publications

59

Journal Article

(43 outputs)
YearCitationAltmetrics
2019Adulcikas JA, Sonda S, Norouzi S, Sohal SS, Myers S, 'Targeting the zinc transporter ZIP7 in the treatment of insulin resistance and type 2 diabetes', Nutrients, 11, (2) pp. 408. ISSN 2072-6643 (2019) [Refereed Article]

DOI: 10.3390/nu11020408 [eCite] [Details]

Citations: Scopus - 1Web of Science - 2

Co-authors: Adulcikas JA; Sonda S; Norouzi S; Sohal SS

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2019Atto B, Eapen MS, Sharma P, Frey U, Ammit AJ, et al., 'New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways', Clinical Science, 133, (14) pp. 1663-1703. ISSN 0143-5221 (2019) [Refereed Article]

DOI: 10.1042/CS20181009 [eCite] [Details]

Co-authors: Atto B; Eapen MS; Larby J; Haug G; Weber HC; Mabeza G; Tristram S; Geraghty DP; Flanagan K; Sohal SS

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2019Eapen MS, Gaikwad AV, Thompson IE, Lu W, Myers S, et al., 'The effectiveness of immunosuppressive cyclosporin in attenuating the progression of interstitial lung diseases', Journal of Thoracic Disease, 11 pp. S1139-S1142. ISSN 2072-1439 (2019) [Letter or Note in Journal]

DOI: 10.21037/jtd.2019.04.44 [eCite] [Details]

Co-authors: Eapen MS; Gaikwad AV; Thompson IE; Lu W; Sohal SS

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2019Eapen MS, Sharma P, Gaikwad AV, Lu W, Myers S, et al., 'Epithelial-mesenchymal transition is driven by transcriptional and post transcriptional modulations in COPD: implications for disease progression and new therapeutics', International Journal of Chronic Obstructive Pulmonary Disease, 14 pp. 1603-1610. ISSN 1178-2005 (2019) [Letter or Note in Journal]

DOI: 10.2147/COPD.S208428 [eCite] [Details]

Co-authors: Eapen MS; Gaikwad AV; Lu W; Sohal SS

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2019Eapen MS, Sharma P, Thompson IE, Lu W, Myers S, et al., 'Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies', Laboratory Investigation, 99, (2) pp. 150-157. ISSN 0023-6837 (2019) [Refereed Article]

DOI: 10.1038/s41374-018-0146-0 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Eapen MS; Thompson IE; Lu W; Sohal SS

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2019Maglagola E, Chen R, Bombardo M, Saponara E, Dentice M, et al., 'Local hyperthyroidism promotes pancreatic acinar cell proliferation during acute pancreatitis', Journal of Pathology ISSN 0022-3417 (2019) [Refereed Article]

DOI: 10.1002/path.5247 [eCite] [Details]

Co-authors: Hills AP; Sonda S

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2019Norouzi S, Adulcikas J, Henstridge DC, Sonda S, Sohal SS, et al., 'The zinc transporter Zip7 is downregulated in skeletal muscle of insulin-resistant cells and in mice fed a high-fat diet', Cells, 8, (7) pp. 663. ISSN 2073-4409 (2019) [Refereed Article]

DOI: 10.3390/cells8070663 [eCite] [Details]

Co-authors: Norouzi S; Adulcikas J; Henstridge DC; Sonda S; Sohal SS

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2019Coates TS, Fell JW, Myers SA, Bootes MR, Wu SX, 'The effect of concurrent high intensity low volume with supplemental low intensity high volume resistance training on salivary cortisol and testosterone levels in elite athletes', Journal of Australian Strength and Conditioning ISSN 1836-649X (In Press) [Refereed Article]

[eCite] [Details]

Co-authors: Coates TS; Fell JW

2018Eapen MS, Hansbro PM, Larssona-Callerfelt AK, Jolly MK, Myers S, et al., 'Chronic obstructive pulmonary disease and lung cancer: underlying pathophysiology and new therapeutic modalities', Drugs, 78, (16) pp. 1717-1740. ISSN 0012-6667 (2018) [Refereed Article]

DOI: 10.1007/s40265-018-1001-8 [eCite] [Details]

Citations: Scopus - 6Web of Science - 8

Co-authors: Eapen MS; Larby J; Haug G; Hardikar A; Weber HC; Sohal SS

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2018Ghanbari-Niaki A, Saeidi A, Ahmadian M, Gharahcholo L, Naghavi N, et al., 'The combination of exercise training and Zataria multiflora supplementation increase serum irisin levels in postmenopausal women', Integrative Medicine Research, 7, (1) pp. 44-52. ISSN 2213-4220 (2018) [Refereed Article]

DOI: 10.1016/j.imr.2018.01.007 [eCite] [Details]

Citations: Web of Science - 3

Co-authors: Williams A

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2018Adulcikas J, Norouzi S, Bretag L, Sohal SS, Myers S, 'The zinc transporter SLC39A7 (ZIP7) harbours a highly-conserved histidinerich N-terminal region that potentially contributes to zinc homeostasis in the endoplasmic reticulum', Computers in Biology and Medicine, 100 pp. 196-202. ISSN 0010-4825 (2018) [Refereed Article]

DOI: 10.1016/j.compbiomed.2018.07.007 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Adulcikas J; Norouzi S; Sohal SS

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2018Gundamaraju R, Vemuri R, Chong WC, Myers S, Norouzi S, et al., 'Interplay between Endoplasmic Reticular Stress and Survivin in Colonic Epithelial Cells', Cells, 7, (10) Article 171. ISSN 2073-4409 (2018) [Refereed Article]

DOI: 10.3390/cells7100171 [eCite] [Details]

Citations: Web of Science - 1

Co-authors: Vemuri R; Chong WC; Norouzi S; Shastri MD; Eri R

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2018Jolly MK, Ward C, Eapen MS, Myers S, Hallgren O, et al., 'Epithelial-mesenchymal transition, a spectrum of states: role in lung development, homeostasis, and disease', Developmental Dynamics, 247, (3) pp. 346-358. ISSN 1058-8388 (2018) [Refereed Article]

DOI: 10.1002/dvdy.24541 [eCite] [Details]

Citations: Scopus - 36Web of Science - 34

Co-authors: Eapen MS; Sohal SS

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2018Norouzi S, Adulcikas J, Sohal SS, Myers S, 'Zinc stimulates glucose oxidation and glycemic control by modulating the insulin signaling pathway in human and mouse skeletal muscle cell lines', PLoS One, 13, (1) Article e0191727. ISSN 1932-6203 (2018) [Refereed Article]

DOI: 10.1371/journal.pone.0191727 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Norouzi S; Adulcikas J; Sohal SS

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2018Eapen MS, Myers S, Lu W, Tanghe C, Sharma P, et al., 'sE-cadherin and sVE-cadherin indicate active epithelial/endothelial to mesenchymal transition (EMT and EndoMT) in smokers and COPD: implications for new biomarkers and therapeutics', Biomarkers ISSN 1354-750X (2018) [Contribution to Refereed Journal]

DOI: 10.1080/1354750X.2018.1479772 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Eapen MS; Lu W; Tanghe C; Sohal SS

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2017Norouzi S, Adulcikas J, Sohal SS, Myers S, 'Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease', Journal of Biomedical Science, 24 pp. 1-10. ISSN 1021-7770 (2017) [Refereed Article]

DOI: 10.1186/s12929-017-0394-0 [eCite] [Details]

Citations: Scopus - 9Web of Science - 14

Co-authors: Norouzi S; Adulcikas J; Sohal SS

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2017Molina E, Chew GS, Myers SA, Clarence EM, Eales JM, et al., 'A Novel Y-Specifc Long NonCoding RNA Associated with Cellular Lipid Accumulation in HepG2 cells and Atherosclerosisrelated Genes', Scientific Reports, 7 pp. 1-12. ISSN 2045-2322 (2017) [Refereed Article]

DOI: 10.1038/s41598-017-17165-9 [eCite] [Details]

Citations: Scopus - 7Web of Science - 5

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2016Myers SA, Norouzi S, 'The Relationship between Zinc and Insulin Signaling: Implications for Type 2 Diabetes', 6, (4) pp. 90-91. ISSN 1758-1915 (2016) [Edited Journal]

[eCite] [Details]

Co-authors: Norouzi S

2015Chew GS, Gawned M, Molina E, Myers SA, 'Quantitative analysis of orphan nuclear receptors in insulin-resistant C2C12 skeletal muscle cells', Journal of Diabetes & Metabolism, 6, (11) Article 626. ISSN 2155-6156 (2015) [Refereed Article]

DOI: 10.4172/2155-6156.1000626 [eCite] [Details]

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2015Myers SA, 'Zinc transporters and zinc signaling: new insights into their role in type 2 diabetes', International Journal of Endocrinology Article 167503. ISSN 1687-8337 (2015) [Refereed Article]

DOI: 10.1155/2015/167503 [eCite] [Details]

Citations: Scopus - 23Web of Science - 23

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2015Tomaszewski M, Eales J, Denniff M, Myers S, Chew GS, et al., 'Renal mechanisms of association between fibroblast growth factor 1 and blood pressure', Journal of the American Society of Nephrology, 26, (12) pp. 3151-3160. ISSN 1046-6673 (2015) [Refereed Article]

DOI: 10.1681/ASN.2014121211 [eCite] [Details]

Citations: Scopus - 9Web of Science - 8

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2014Chew GS, Myers S, Shu-Chien AC, Muhammad TST, 'Interleukin-6 inhibition of peroxisome proliferator-activated receptor alpha expression is mediated by JAK2- and PI3K-induced STAT1/3 in HepG2 hepatocyte cells', Molecular and Cellular Biochemistry, 388, (1-2) pp. 25-37. ISSN 0300-8177 (2014) [Refereed Article]

DOI: 10.1007/s11010-013-1896-z [eCite] [Details]

Citations: Scopus - 8Web of Science - 7

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2014Myers S, Williamson S, 'Nutrition, Genes and Modern Disease: A Current Dilemma or a Legacy of our Past', Journal of Diabetes & Metabolism, 5, (7) pp. 1-5. ISSN 2155-6156 (2014) [Refereed Article]

DOI: 10.4172/2155-6156.1000393 [eCite] [Details]

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2013Chew G-S, Myers S, Ooi KL, Shu-Chien AC, Muhammad TST, 'Interleukin-6 Induces the Down Regulation of Human Peroxisome Proliferator Activated Receptor Alpha via the MAPK-induced STAT Pathway in Human Hepatocytes', Journal of Biochemical and Pharmacological Research, 1, (4) pp. 204-211. ISSN 2168-8761 (2013) [Refereed Article]

[eCite] [Details]

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2013Myers SA, Nield A, Chew G-S, Myers MA, 'The zinc transporter, Slc39a7 (Zip7) is implicated in glycaemic control in skeletal muscle cells', PLoS One, 8, (11) Article e79316. ISSN 1932-6203 (2013) [Refereed Article]

DOI: 10.1371/journal.pone.0079316 [eCite] [Details]

Citations: Scopus - 31Web of Science - 33

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2013Nield A, Quarrell S, Myers S, 'Community Based Early Intervention for the Prevention of Type 2 Diabetes: A Case Report of the Kahnawake Schools Diabetes Prevention Project', Journal of Diabetes & Metabolism, 4, (6) pp. 1-6. ISSN 2155-6156 (2013) [Refereed Article]

DOI: 10.4172/2155-6156.1000277 [eCite] [Details]

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2013Fernandez-Rojo MA, Gongora M, Fitzsimmons RL, Martel N, Martin SD, et al., 'Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling', Cell Reports, 4, (2) pp. 238-247. ISSN 2211-1247 (2013) [Refereed Article]

DOI: 10.1016/j.celrep.2013.06.017 [eCite] [Details]

Citations: Scopus - 23Web of Science - 24

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2012Myers SA, Blackmore MJ, Smith TF, Carter RW, 'Climate change and stewardship: strategies to build community resilience in the Capricorn Coast', Australasian Journal of Environmental Management, 19, (3) pp. 164-181. ISSN 1448-6563 (2012) [Refereed Article]

DOI: 10.1080/14486563.2011.646755 [eCite] [Details]

Citations: Scopus - 4Web of Science - 5

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2011Crowther LM, Wang S-CM, Eriksson NA, Myers SA, Murray LA, et al., 'Chicken ovalbumin upstream promoter-transcription factor II regulates nuclear receptor, myogenic, and metabolic gene expression in skeletal muscle cells', Physiological Genomics, 43 pp. 213-227. ISSN 1094-8341 (2011) [Refereed Article]

DOI: 10.1152/physiolgenomics.00195.2010 [eCite] [Details]

Citations: Scopus - 14Web of Science - 14

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2011Wang S-CM, Myers SA, Eriksson NA, Fitzsimmons RL, Muscat GEO, 'Nr4a1 siRNA Expression Attenuates αMSH Regulated Gene Expression in 3T3-L1 Adipocytes', Molecular Endocrinology, 25, (2) pp. 291-306. ISSN 0888-8809 (2011) [Refereed Article]

DOI: 10.1210/me.2010-0231 [eCite] [Details]

Citations: Scopus - 16Web of Science - 16

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2010Raichur S, Fitzsimmons RL, Myers SA, Pearen MA, Lau P, et al., 'Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle', Nucleic Acids Research, 38, (13) pp. 4296-4312. ISSN 0305-1048 (2010) [Refereed Article]

DOI: 10.1093/nar/gkq180 [eCite] [Details]

Citations: Scopus - 35Web of Science - 32

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2010Wang S-CM, Myers S, Dooms C, Capon R, Muscat GEO, 'An ERRbeta/gamma agonist modulates GRalpha expression, and glucocorticoid responsive gene expression in skeletal muscle cells', Molecular and Cellular Endocrinology, 315, (1-2) pp. 146-152. ISSN 0303-7207 (2010) [Refereed Article]

DOI: 10.1016/j.mce.2009.07.012 [eCite] [Details]

Citations: Scopus - 21Web of Science - 20

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2009Lai J, Myers SA, Lawrence MG, Odorico DM, Clements JA, 'Direct Progesterone Receptor and Indirect Androgen Receptor Interactions with the Kallikrein-Related Peptidase 4 Gene Promoter in Breast and Prostate Cancer', Molecular Cancer Research, 7, (1) pp. 129-41. ISSN 1541-7786 (2009) [Refereed Article]

DOI: 10.1158/1541-7786.MCR-08-0218 [eCite] [Details]

Citations: Scopus - 28Web of Science - 27

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2009Myers SA, Eriksson N, Burrow R, Wang S-CM, Muscat GEO, 'β-Adrenergic signaling regulates NR4A nuclear receptor and metabolic gene expression in multiple tissues', Molecular and Cellular Endocrinology, 309, (1-2) pp. 101-108. ISSN 0303-7207 (2009) [Refereed Article]

DOI: 10.1016/j.mce.2009.05.006 [eCite] [Details]

Citations: Scopus - 49Web of Science - 53

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2008He Y, Hryciw DH, Carroll ML, Myers SA, Whitbread AK, et al., 'The Ubiquitin-Protein Ligase Nedd4-2 Differentially Interacts with and Regulates Members of the Tweety Family of Chloride Ion Channels', The Journal of biological chemistry, 283, (35) pp. 24000-10. ISSN 0021-9258 (2008) [Refereed Article]

DOI: 10.1074/jbc.M803361200 [eCite] [Details]

Citations: Scopus - 20Web of Science - 21

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2008He Y, Ramsay AJ, Hunt ML, Whitbread AK, Myers SA, et al., 'N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2)', Biochemical Journal, (412) pp. 45-55. ISSN 0264-6021 (2008) [Refereed Article]

DOI: 10.1042/BJ20071722 [eCite] [Details]

Citations: Scopus - 14Web of Science - 11

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2008Kaushal A, Myers SA, Dong Y, Lai J, Tan OL, et al., 'A Novel Transcript Fromthe KLKP1Gene Is Androgen Regulated,Down-Regulated During Prostate Cancer Progression and Encodes the First Non-Serine Protease Identified Fromthe Human Kallikrein Gene Locus', The Prostate, 68 pp. 381-399. ISSN 0270-4137 (2008) [Refereed Article]

DOI: 10.1002/pros.20685 [eCite] [Details]

Citations: Scopus - 19Web of Science - 17

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2008Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, et al., 'The Orphan Nuclear Receptor, NOR-1, a Target of -Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle', Endocrinology, 149, (6) pp. 2853-2865. ISSN 0013-7227 (2008) [Refereed Article]

DOI: 10.1210/en.2007-1202 [eCite] [Details]

Citations: Scopus - 99Web of Science - 97

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2006Myers SA, Wang S-C M, Muscat GEO, 'The Chicken Ovalbumin Upstream Promoter-Transcription Factors Modulate Genes and Pathways Involved in Skeletal Muscle Cell Metabolism', Journal of Biological Chemistry, 281, (34) pp. 24149 -24160. ISSN 0021-9258 (2006) [Refereed Article]

DOI: 10.1074/jbc.M601941200 [eCite] [Details]

Citations: Scopus - 33Web of Science - 34

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2005Dong Y, Bui LT, Odorico DM, Tan OL, Myers SA, et al., 'Compartmentalized expression of kallikrein 4 (KLK4/hK4) isoforms in prostate cancer: nuclear, cytoplasmic and secreted forms', Endocrine - Related Cancer, 12 pp. 875-889. ISSN 1351-0088 (2005) [Refereed Article]

DOI: 10.1677/erc.1.01062 [eCite] [Details]

Citations: Scopus - 47Web of Science - 47

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2001Hooper JD, Bui LT, Rae FK, Harvey TJ, Myers SA, et al., 'Identification and Characterization of KLK14, a Novel Kallikrein Serine Protease Gene Located on Human Chromosome 19q13.4 and Expressed in Prostate and Skeletal Muscle', Genomics: International Journal for Analysis of The Human and Other Genomes, 73 pp. 117-122. ISSN 0888-7543 (2001) [Refereed Article]

DOI: 10.1006/geno.2000.6490 [eCite] [Details]

Citations: Scopus - 53Web of Science - 52

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2001Myers SA, Clements JA, 'Kallikrein 4 (KLK4), A New Member of the Human Kallikrein Gene Family Is Upregulated By Estrogen and Progesterone in the Human Endometrial Cancer Cell Line, KLE', The Journal of Clinical Endocrinology & Metabolism, 86, (5) pp. 2323-2326. ISSN 0021-972X (2001) [Refereed Article]

DOI: 10.1210/jc.86.5.2323 [eCite] [Details]

Citations: Scopus - 46Web of Science - 43

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2000Harvey TJ, Hoopert JD, Myers SA, Stephenson S-A, Ashworth L, et al., 'Tissue-specific Expression Patterns and Fine Mapping of the Human Kallikrein (KLK) Locus on Proximal 19q13.4', International Journal of Biological Chemistry, 275, (48) pp. 37397-37406. ISSN 1819-155X (2000) [Refereed Article]

DOI: 10.1074/jbc.M004525200 [eCite] [Details]

Citations: Scopus - 139Web of Science - 131

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Chapter in Book

(5 outputs)
YearCitationAltmetrics
2015Smith TF, Choy Dl, Thomsen DC, Serrao-Neumann S, Crick F, et al., 'Adapting Australian coastal regions to climate change', Climate Change and the Coast: Building Resilient Communities, Taylor and Francis, BC Glavovic, M Kelly, R Kay & A Travers (ed), United States, pp. 269-284. ISBN 978-1-4822-8858-2 (2015) [Research Book Chapter]

[eCite] [Details]

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2014Myers SA, Nield A, 'Zinc, Zinc Transporters and Type 2 Diabetes', Endocrine Diseases, Concept Press Ltd., iConcept Press (ed), Hong Kong, pp. 25-48. ISBN 978-1-922227-30-0 (2014) [Research Book Chapter]

[eCite] [Details]

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2013Siddique MAL, Zafrin S, Myers SA, Smith T, Babcock R, et al., 'Co-Learning in Marine Protected Areas for Integrated Coastal Zone Management', Global Challenges in Integrated Coastal Zone Management, John Wiley & Sons, E Moksness, E Dahl & J Stottrup (ed), United Kingdom, pp. 192-205. ISBN 978-0-470-65756-0 (2013) [Research Book Chapter]

DOI: 10.1002/9781118496480.ch15 [eCite] [Details]

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2012Myers SA, Thomsen DC, Tarte D, Dutra LX, Ellis N, et al., 'Adaptive learning and coastal management in South-east Queensland, Australia', Sustainable Coastal Management and Climate Adaptation: Global Lessons from Regional Approaches in Australia, CSIRO Publishing, R Kenchington, L Stocker & D Wood (ed), Australia, pp. 157-176. ISBN 9780643100275 (2012) [Research Book Chapter]

[eCite] [Details]

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2011Smith TF, Myers SA, Thomsen DC, Rosier J, 'Integrated coastal zone management and planning', Marine Resources Management, LexisNexis Butterworths, W Gullett, C Schofield & J Vince (ed), Australia, pp. 109-121. ISBN 9780409327441 (2011) [Research Book Chapter]

[eCite] [Details]

Review

(5 outputs)
YearCitationAltmetrics
2017Eapen MS, Myers S, Walters EH, Sohal SS, 'Airway inflammation in chronic obstructive pulmonary disease (COPD): a true paradox', Expert Review of Respiratory Medicine, 11, (10) pp. 827-839. ISSN 1747-6348 (2017) [Substantial Review]

DOI: 10.1080/17476348.2017.1360769 [eCite] [Details]

Citations: Scopus - 26Web of Science - 1

Co-authors: Eapen MS; Walters EH; Sohal SS

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2017Myers S, Shastri M, Adulcikas JA, Sohal SS, Norouzi S, 'Zinc and gastrointestinal disorders: a role for the zinc transporters Zips and ZnTs', Current Pharmaceutical Design, 23, (16) pp. 2328-2332. ISSN 1381-6128 (2017) [Review Several Works]

DOI: 10.2174/1381612823666170124115850 [eCite] [Details]

Citations: Scopus - 5Web of Science - 3

Co-authors: Shastri M; Adulcikas JA; Sohal SS; Norouzi S

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2012Myers SA, Nield A, Myers M, 'Zinc Transporters, Mechanisms of Action and Therapeutic Utility: Implications for Type 2 Diabetes Mellitus', International Journal of Sport Nutrition & Exercise Metabolism pp. 1-13. ISSN 1526-484X (2012) [Substantial Review]

DOI: 10.1155/2012/173712 [eCite] [Details]

Citations: Scopus - 49Web of Science - 14

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2007Myers SA, Pearen M, Leong G, Muscat G, 'Orphan Nuclear Receptor Signalling and Skeletal Muscle: Insights into Metabolic Disorders', Australian biochemist, 38, (1) pp. 8-11. ISSN 1443-0193 (2007) [Review Several Works]

[eCite] [Details]

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2004Clements JA, Willemsen NM, Myers SA, Dong Y, 'The tissue Kallikrein Family of Serine Proteases: Functional Roles in Human Disease and Potential as Clinical Biomarkers', Critical reviews in clinical laboratory sciences, 41, (3) pp. 265-312. ISSN 1040-8363 (2004) [Substantial Review]

[eCite] [Details]

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Conference Publication

(2 outputs)
YearCitationAltmetrics
2016Norouzi S, Myers SA, 'Zinc is critical for the activation of cell signalling molecules in skeletal muscle: implications for insulin resistance and type 2 diabetes', Tasmanian Health Conference 2016, 30 July, 2016, Hobart, Tasmania (2016) [Conference Extract]

[eCite] [Details]

Co-authors: Norouzi S

2010Diaz M, Martel N, Myers SA, Fitzsimmons R, Pearen M, et al., 'Ski transgenic mice are resistant to diet-induced obesity and have altered skeletal muscle metabolic gene expression', Obesity Research & Clinical Practice, 11-15 July, 2010, Stockholm, Sweden, pp. S63. ISSN 1871-403X (2010) [Conference Extract]

DOI: 10.1016/j.orcp.2010.09.123 [eCite] [Details]

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Other Public Output

(4 outputs)
YearCitationAltmetrics
2018Schmidt M, Cannell JA, Flanagan K, Sohal SS, Mulford J, et al., ''Champions' of research', The Examiner, Australia, 2 November 2018 (2018) [Newspaper Article]

[eCite] [Details]

Co-authors: Schmidt M; Cannell JA; Flanagan K; Sohal SS; Mulford J

2017Myers S, 'Zinc and type 2 diabetes', Sunday Examiner, 19 November 2017, p. 6. (2017) [Newspaper Article]

[eCite] [Details]

2017Myers S, 'Zinc controls glucose metabolism independent of insulin in human skeletal muscle: implications for type 2 diabetes', Priceless: The news bulletin for supporters of the Clifford Craig Foundation, Clifford Craig Foundation, November 2017, p. 6. (2017) [Magazine Article]

[eCite] [Details]

2011Myers S, Carter RW, Smith T, 'Climate Change in the Capricorn Coast: an analysis of stewardship potential', Great Barrier Reef Marine Park Authority, Townsville, QLD, 106 (2011) [Government or Industry Research]

[eCite] [Details]

Grants & Funding

Steve has been the recipient of several funding schemes including an NHMRC 'Dora Lush' PhD Scholarship, a University of Queensland Early Career Grant Award and Fellowship Award, a Collaborative Research Network Fellowship, a CSIRO Fellowship and several Clifford Craig Medical Research Trust Award.

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Funding Summary

Number of grants

9

Total funding

$409,652

Projects

Zinc activation of enzymes responsible for insulin signalling and glucose homeostasis in type 2 diabetes (2019)$21,944
Description
The inability to respond sufficiently to insulin gradually erodes our health. Type 2 diabetes (T2D) results from such insulin resistance in peripheral tissues such as skeletal muscle. In fact, skeletal muscle is the major peripheral tissue that accounts for 70-80% of glucose uptake. While there are several theories on how insulin resistance may manifest, the molecular mechanisms are still largely unclear. Given the major impact this disorder has on the health of our communities, there is an urgent need for continued basic science to understand these mechanisms to appropriately design better therapeutics to treat this disorder. Recently, zinc has been highlighted as a critical metal ion implicated in maintaining glucose homeostasis and therefore is a vital target to study its effects on insulin resistance. We have recently published a role for this metal ion in regulating glucose metabolism in skeletal muscle cells through the concomitant action of several cell signalling molecules. However, it is unclear how this is achieved. Accordingly, this study aims to address the molecular mechanisms whereby zinc can contribute to the regulation of glucose metabolism in insulin resistant skeletal muscle.
Funding
Clifford Craig Foundation ($21,944)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Myers SA; Sohal SS; Sonda S; Williams AD; Adulcikas JA
Year
2019
Evaluation of new therapeutic targets in idiopathic pulmonary fibrosis (IPF): insights from Australian IPF registry tissue analysis (2019 - 2020)$72,728
Description
IPF is a highly destructive lethal disease of the lungs, but with very little information available on the underlying mechanisms. We are going to explore the process of epithelial cell plasticity (or EMT) and a similar process in blood vessel endothelium (Endo-MT). This work will lead to improved diagnosis and treatment of this nasty lung condition. The project brings together well-characterized patients from the Australian IPF registry, blood samples we have collected from them and innovative techniques to reset thinking about the underlying pathological processes active in this illness.
Funding
Clifford Craig Foundation ($72,728)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Sohal SS; Walters EH; Myers SA; Geraghty DP; Chia Collin; Larby J; Haug G; Eapen MS
Period
2019 - 2020
Airway macrophage phenotypic switch drives epithelial-mesenchymal transition (EMT) in smokers and COPD: implications for early therapy. (2019 - 2020)$100,000
Description
The M1/M2 phenotype balance has also been especially discussed in the cancer literature as an orchestrator of EMT in driving epithelial malignancies. Such new and translatable insights in COPD are an international priority given the current absence of any significant disease trajectory-modifying drug interventions in clinical practice. Here we continue to focus on EMT in COPD, but especially investigating the role of macrophage-associated cytokines in driving EMT in different patient groups leading to new therapeutic targets.
Funding
Rebecca L Cooper Medical Research Foundation ($100,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Sohal SS; Geraghty DP; Myers SA
Period
2019 - 2020
Zinc contributes to glucose control in the absence of insulin in skeletal muscle (2018)$21,460
Description
The inability of the body to respond adequately to insulin following a meal has serious consequences on health. Insulin aids in the uptake of glucose into cells, providing the liver with a store of glucose to maintain blood glucose when needed, and as a vital fuel for energy in skeletal muscle. In an insulin-resistant state, cells cannot utilise glucose, which subsequently causes serious medical conditions including obesity, hypertension, cardiovascular disease and type 2 diabetes. Previously, emerging research has shown that zinc and the proteins that transport zinc in cells play a crucial role in activating molecules involved in glucose uptake in skeletal muscle. Recently we have shown that zinc can promote glucose utilisation in the absence of insulin in skeletal muscle. This presents with an opportunity to manipulate zinc metabolism therapeutically to provide an alternative pathway for providing glucose to cells during an insulin-resistant state.
Funding
Clifford Craig Foundation ($21,460)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Myers SA; Sohal SS; Fettke G
Year
2018
Epithelial mesenchymal transition (EMT) in the lungs and airways in Idiopathic Pulmonary Fibrosis (IPF) (2018 - 2019)$48,354
Description
IPF is a highly destructive lethal disease of the lungs, but with very little information available on the underlying mechanisms. We are going to explore the process of epithelial cell plasticity (or EMT) and a similar process in blood vessel endothelium (Endo-MT). This work will lead to improved diagnosis and treatment of this nasty lung condition. The project brings together well-characterized patients from the Australian IPF registry, blood samples we have collected from them and innovative techniques to reset thinking about the underlying pathological processes active in this illness.
Funding
Clifford Craig Foundation ($48,354)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Sohal SS; Walters EH; Myers SA; Ahuja KDK; Chia Collin; Larby J; Haug G; Eapen MS
Period
2018 - 2019
The effect of current and investigational COPD pharmacological agents on the airway Epithelial-Mesenchymal Transition (EMT) process in smokers and COPD (2017 - 2018)$72,727
Description
Small airway fibrosis is the main contributor to physiological airway obstruction in COPD. The other main airway pathology in COPD is lung cancer; up to 70% of smoking related lung cancer occurs in mild-moderate COPD. EMT may underlie both pathological features; if true this opens up major new therapeutic possibilities. We aim to investigate the effect of pharmacological agents on the EMT in airways of smokers and COPD.
Funding
Clifford Craig Foundation ($72,727)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Sohal SS; Chia Collin; Larby J; Haug G; Noor WD; Myers SA; Eapen MS
Period
2017 - 2018
Exploring zinc to improve insulin sensitivity and glucose metabolism in human insulin-resistant skeletal muscle (2016)$25,959
Description
Describe your project: Insulin resistance (IR) is a disorder that is characterised by the failure of cells in the body to respond to insulin and therefore use glucose efficiently as an energy source. Prolonged IR can lead to Type 2 diabetes (T2D), a devastating disease that is intensifying worldwide. T2D is associated with related diseases including heart disease, obesity, mental illness, and cancer. Although IR is well-researched, its molecular mechanisms are still unclear. Recently, studies involving zinc and the proteins that transport zinc in cells (zinc transporters) have been highlighted for their role in regulating genes and proteins involved in disease. Specifically, one zinc transporter designated as Zip7 is involved in regulating zinc in cells and thus preserving cell function. Accordingly, this project aims to understand the molecular mechanisms of Zip7 and how it can be used to reverse IR and could therefore be amendable to treatment options for T2D.
Funding
Clifford Craig Foundation ($25,959)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Myers SA; Sohal SS; Fettke G
Year
2016
Using exercise to improve the health of Tasmanian caregivers (2016)$7,274
Description
This project tests whether weekly exercise/gym sessions improve the health of carers of children with autism and the motor skills of their child.This project has three objectives:1) to improve the physical health and mental well-being of caregivers of children with Autism Spectrum Disorder (ASD) througha 12 week exercise program2) to provide an expedited motor skills assessment process for children (2-5 years) with ASD3) to identify caregiver friendly strategies that can assist in developing and improving the motor skills of children with ASD
Funding
Tasmanian Community Fund ($7,274)
Scheme
Grant
Administered By
University of Tasmania
Research Team
McCann DE; Williams AD; Quarmby L; Myers SA; Norris K
Year
2016
Epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): role in both airway fibrosis and lung cancer (2016)$39,206
Description
Small airway fibrosis is the main contributor to physiological airway obstruction in COPD. The other main airway pathology in COPD is lung cancer; up to 70% of smoking related lung cancer occurs in mild-moderate COPD. EMT may underlie both pathological features; if true this opens up major new therapeutic possibilities. We aim to investigate EMT in airways of smokers and COPD.
Funding
Clifford Craig Foundation ($39,206)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Sohal SS; Chia Collin; Larby J; Haug G; Eri RD; Myers SA; Noor WD
Year
2016

Research Supervision

Steve has supervised many students, both in undergraduate and postgraduate studies. He has supervised successfully 7 PhD students and many honours students

Current

9

Completed

1

Current

DegreeTitleCommenced
PhDThe Role of Zinc and the Zip7 Transporter in Disease Processes Associated with IR in Skeletal Muscle2015
PhDInvestigating the Inner World of Stressed Goblet Cell2016
PhDStructural and Functional Analysis of the Zinc Transporter Protein Zip7: Implications for therapeutic utility in metabolic disease2016
PhDInvestigation of the Mechanism of Interaction between anti-beta 2 Glycoprotein 1 Antibodies (Type A and B), 2GP1 and Platelets from Health Individuals and Patients with Autoimmune Disease2016
PhDA Novel Method of Treatment for Type II Diabetic Patients2018
PhDThe Effectiveness of Eccentric Exercise Training in the Treatment of Type 2 Diabetes Mellitus2018
PhDRole of Endothelial to MesenchymalTransition (EndoMT) in Pulmonary Hypertension (PH) and Interstitial Fibrosis in Idiopathic Pulmonary Ffibrosis (IPF)2018
PhDCapsaicin and Glucose Control: Mechanism of action2019
PhDAngiogenesis in COPD Airways: to investigate the patho-biology of a putative cancerogenic stroma2019

Completed

DegreeTitleCompleted
PhDAqueous Humour Protein Imbalances in Primary Open-angle Glaucoma and Their Effects on Trabecular Meshwork Cell Function
Candidate: Esther Lara Ashworth Briggs
2018