Profiles

Stephen Richards

Dr Stephen Richards

Stephen Richards

Senior Lecturer

Room 414-12 (Level 4) , Medical Science 1

+61 3 6226 2673 (phone)

Stephen.Richards@utas.edu.au

Biography

Following a PhD under Emeritus Prof Mike Clark at the University of Tasmania, Dr Richards did post-doctoral research at the Baker Institute in Melbourne on cardioprotection (with Frank Rosenfeldt and Bob Conyers) and calcium signalling (with Alex Bobik and Craig Neylon) in normal and failing hearts.

Following two years at an INSERM unit in Montpellier, France, looking at intracellular Ca and pH signalling in normal and failing hearts with Michel Pucéat, he returned to the University of Melbourne to work briefly with Lea Delbridge on cardiac Ca signalling, supported by an NHMRC Howard Florey Centenary Fellowship.

In mid 1999, Dr Richards took up an academic appointment with the School of Medicine at UTAS, and resumed PhD work on muscle metabolism with Profs Mike Clark (Emeritus) and Steve Rattigan. In 2006 his lab joined the novated Menzies Institute for Medical Research under the Directorship of Prof Simon Foote.

Administrative expertise

Honours and Graduate Research Coordination
Senior Management Team, Menzies Institute for Medical Research
Deputy Chair Animal Ethics Committee

Teaching

Teaching responsibility

Dr Richards teaches extensively in undergraduate Biochemistry units, coordinating a number of second year units. He also has overall responsibility for coordinating the Honours programs offered by Medicine, including students doing research projects with the Menzies, and serve as Graduate Coordinator for Medicine, and as one of two GRC's for the Menzies Research Institute

CBA221 - Biochemistry A (Pharmacy)
CBA235 - Biochemistry (Agriculture)
CBA260 - Biochemistry: Metabolism & Nutrition
CBA265 - Molecular Biology in Health & Disease
CBA343 - Advanced Biochemistry and Molecular Biology

Research Invitations

Co-organiser and chair of the Freycinet Symposium on 'Impact of muscle blood flow on diabetes and exercise' Tasmania, 2004
Invited speaker and chair of symposium on microbubbles at The 5th International Workshop on Drug Delivery Systems in the Czech Republic in May 15-18, 2007
Invited speaker, Heart Foundation Research Centre, School of Medical Science, Griffith Institute of Health and Medical Research, May 15, 2008
Invited speaker and organiser of symposium on microbubbles at The 6th International Workshop on Drug Delivery Systems in the Czech Republic in October 3-6, 2008

View more on Dr Stephen Richards in WARP

Research Themes

Dr Richards' Group has provided considerable evidence that the metabolism of muscle is heavily influenced by the supply of blood to the myocytes via the microvasculature, not only during exercise, but also upon exposure to insulin following a meal, when the muscle must rapidly store dietary glucose as muscle glycogen.

The Group has also found that the actions of insulin on microvascular blood flow are impaired or absent in obese, or insulin resistant humans and animals. Their three chief aims are:

To understand the precise mechanism by which microvascular flow is altered to enhance delivery of nutrients and hormones (such as insulin itself) to muscle cells;
To determine the biochemical nature and causes of impairment of microvascular blood flow regulation by insulin in pathological states such as insulin resistance;
To discover alternative means of enhancing microvascular blood flow to overcome the impairment associated with insulin resistance.

The Group has developed a range of techniques for measuring microvascular blood flow in muscle, and couples these with techniques for assessing muscle metabolism in animal models of obesity, insulin resistance, diabetes and exercise training. Recent projects have focussed on:

the vascular and metabolic actions of the adipocyte-derived hormone adiponectin;
enhancement of the vascular and metabolic actions of insulin by agents that augment nitric oxide signalling, and AMPK signalling;
the role of the CNS in insulin action in the microvasculature;
analysis of the contribution of vasomotion to enhanced microvascular delivery by insulin.

Awards

NH&MRC Howard Florey Centenary Fellowship (1999)
Simone and Cino Del Duca Foundation Research Fellowship (1998)
American Heart Association Young Investigator Award (1996)

Fields of Research

Endocrinology (320208)
Systems physiology (320803)
Cardiology (incl. cardiovascular diseases) (320101)
Epidemiology (420299)
Gene and molecular therapy (320601)
Agricultural biotechnology diagnostics (incl. biosensors) (300101)
Respiratory diseases (320103)
Cell metabolism (310103)
Animal physiology - systems (310910)
Peripheral nervous system (320906)
Basic pharmacology (321401)
Receptors and membrane biology (310110)
Animal immunology (310905)
Clinical pharmacology and therapeutics (321402)
Medical biochemistry - carbohydrates (320502)
Aboriginal and Torres Strait Islander public health and wellbeing (450417)
Health services and systems (420399)
Animal physiology - cell (310909)
Zoology (310999)
Medical biochemistry - nucleic acids (320505)
Protein trafficking (310108)
Public health nutrition (321005)
Medical biotechnology (320699)
Sensory systems (320907)
Exercise physiology (420702)

Research Objectives

Clinical health (200199)
Expanding knowledge in the biomedical and clinical sciences (280103)
Prevention of human diseases and conditions (200104)
Expanding knowledge in the health sciences (280112)
Human pharmaceutical treatments (240803)
Disease distribution and transmission (incl. surveillance and response) (200404)
Human diagnostics (240802)
Diagnosis of human diseases and conditions (200101)
Specific population health (excl. Indigenous health) (200599)
Expanding knowledge in the biological sciences (280102)
Expanding knowledge in the environmental sciences (280111)
Treatment of human diseases and conditions (200105)
Nutrition (200410)
Climatological hazards (e.g. extreme temperatures, drought and wildfires) (190401)
Public health (excl. specific population health) (200499)

Publications

Total publications

Highlighted publications

(9 outputs)

Year	Type	Citation
2011	Journal Article	Bussey CT, Kolka CM, Rattigan S, Richards SM, 'Adiponectin opposes endothelin-1-mediated vasoconstriction in the perfused rat hindlimb', American Journal of Physiology: Heart and Circulatory Physiology, 301, (1) pp. H79-H86. ISSN 0363-6135 (2011) [Refereed Article] DOI: 10.1152/ajpheart.00864.2010 [eCite] [Details] Citations: Scopus - 19Web of Science - 21 Co-authors: Bussey CT; Kolka CM; Rattigan S Tweet
2011	Journal Article	Genders AJ, Bradley EA, Rattigan S, Richards SM, 'cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle', American Journal of Physiology: Endocrinology and Metabolism, 301, (2) pp. E342-E350. ISSN 0193-1849 (2011) [Refereed Article] DOI: 10.1152/ajpendo.00691.2010 [eCite] [Details] Citations: Scopus - 19Web of Science - 18 Co-authors: Genders AJ; Bradley EA; Rattigan S Tweet
2007	Journal Article	Rattigan S, Bussey CT, Ross RM, Richards SM, 'Obesity, Insulin Resistance, and Capillary Recruitment', Microcirculation, 14, (4-5) pp. 299-309. ISSN 1073-9688 (2007) [Refereed Article] DOI: 10.1080/10739680701282796 [eCite] [Details] Citations: Scopus - 26Web of Science - 24 Co-authors: Rattigan S; Bussey CT; Ross RM Tweet
2006	Conference Publication	Genders AJ, Rattigan S, Clark MG, Richards SM, 'cGMP degrading phosphodiesterases are expressed differentially in skeletal muscle vasculature', Diabetes, vol 55, Supplement 1, 9-13 June, 2006, Washington, pp. A333. ISSN 0012-1797 (2006) [Conference Extract] [eCite] [Details] Co-authors: Genders AJ; Rattigan S; Clark MG
2006	Journal Article	Mahajan H, Kolka CM, Newman JMB, Rattigan S, Richards SM, et al., 'Vascular and metabolic effects of methacholine in relation to insulin action in muscle', Diabetologia, 49, (4) pp. 713-723. ISSN 0012-186X (2006) [Refereed Article] DOI: 10.1007/s00125-005-0110-6 [eCite] [Details] Citations: Scopus - 4Web of Science - 3 Co-authors: Mahajan H; Kolka CM; Newman JMB; Rattigan S; Clark MG Tweet
2006	Journal Article	Rattigan S, Zhang L, Mahajan H, Kolka CM, Richards SM, et al., 'Factors influencing the hemodynamic and metabolic effects of insulin in muscle', Current Diabetes Reviews, 2, (1) pp. 61-70. ISSN 1573-3998 (2006) [Refereed Article] DOI: 10.2174/157339906775473653 [eCite] [Details] Citations: Scopus - 8 Co-authors: Rattigan S; Zhang L; Mahajan H; Kolka CM; Clark MG Tweet
2004	Journal Article	Mahajan H, Richards SM, Rattigan S, Clark MG, 'Local methacholine but not bradykinin potentiates insulin-mediated capillary recruitment and glucose uptake in muscle in vivo', Diabetologia, 47, (12) pp. 2226-2234. ISSN 0012-186X (2004) [Refereed Article] DOI: 10.1007/s00125-004-1580-7 [eCite] [Details] Citations: Scopus - 20Web of Science - 17 Co-authors: Mahajan H; Rattigan S; Clark MG Tweet
2003	Journal Article	Mahajan H, Richards SM, Rattigan S, Clark MG, 'T-1032, a cyclic GMP phosphodiesterase-5 inhibitor, acutely blocks physiologic insulin-mediated muscle haemodynamic effects and glucose uptake in vivo', British Journal of Pharmacology, 140, (7) pp. 1283-1291. ISSN 0007-1188 (2003) [Refereed Article] DOI: 10.1038/sj.bjp.0705548 [eCite] [Details] Citations: Scopus - 8Web of Science - 7 Co-authors: Mahajan H; Rattigan S; Clark MG Tweet
2003	Conference Publication	Richards SM, Wheatley CM, Zhang L, Rattigan S, Barrett EJ, et al., 'Contraction-mediated muscle capillary recruitment and metabolic responses in vivo are resistant to TNFα', Diabetologia, Vol 46, Supplement 2, 24-29 August, 2003, Paris, pp. A58. ISSN 0012-186X (2003) [Conference Extract] [eCite] [Details] Co-authors: Zhang L; Rattigan S; Clark MG

Journal Article

(52 outputs)

Year	Citation	Altmetrics
2022	Roberts-Thompson KM, Hu D, Russell RD, Greenaway T, Betik AC, et al., 'Impaired postprandial adipose tissue microvascular blood flow responses to a mixed-nutrient meal in first-degree relatives of adults with type 2 diabetes', American Journal of Physiology: Endocrinology and Metabolism, 323, (5) pp. E418-E427. ISSN 0193-1849 (2022) [Refereed Article] DOI: 10.1152/ajpendo.00109.2022 [eCite] [Details] Co-authors: Russell RD; Greenaway T; Premilovac D; Keske MA Tweet
2021	Breenfeldt Andersen A, Jacobson GA, Bejder J, Premilovac D, Richards SM, et al., 'An abductive inference approach to assess the performance‑enhancing effects of drugs included on the World Anti‑Doping Agency Prohibited List', Sports Medicine ISSN 0112-1642 (2021) [Refereed Article] DOI: 10.1007/s40279-021-01450-9 [eCite] [Details] Citations: Scopus - 6Web of Science - 7 Co-authors: Jacobson GA; Premilovac D Tweet
2021	Russell RD, Roberts-Thomson KM, Hu D, Greenaway T, Betik AC, et al., 'Impaired postprandial skeletal muscle vascular responses to a mixed meal challenge in normoglycaemic people with a parent with type 2 diabetes', Diabetologia ISSN 0012-186X (2021) [Refereed Article] DOI: 10.1007/s00125-021-05572-7 [eCite] [Details] Citations: Scopus - 8Web of Science - 7 Co-authors: Russell RD; Greenaway T; Sharman JE; Rattigan S; Premilovac D; Keske MA Tweet
2020	Keske MA, Barrett EJ, Lindner JR, Richter EA, Liu Z, et al., 'Perfusion controls muscle glucose uptake by altering the rate of glucose dispersion in viv', American Journal of Physiology: Endocrinology and Metabolism, 318, (6) pp. E1022-E1036. ISSN 0193-1849 (2020) [Letter or Note in Journal] DOI: 10.1152/ajpendo.00430.2019 [eCite] [Details] Citations: Scopus - 4Web of Science - 4 Co-authors: Keske MA; Premilovac D; Rattigan S Tweet
2020	Thaver S, Foa L, Richards SM, Lyons AB, Zosky GR, 'In utero exposure to diesel exhaust particles, but not silica, alters post-natal immune development and function', Chemosphere, 268 Article 1293142. ISSN 0045-6535 (2020) [Refereed Article] DOI: 10.1016/j.chemosphere.2020.129314 [eCite] [Details] Citations: Scopus - 1Web of Science - 1 Co-authors: Thaver S; Foa L; Lyons AB; Zosky GR Tweet
2019	Attrill EH, Ramsay C, Ross R, Richards S, Sutherland BA, et al., 'Metabolic-vascular coupling in skeletal muscle: a potential role for capillary pericytes?', Clinical and Experimental Pharmacology and Physiology, 47, (3) pp. 520-528. ISSN 0305-1870 (2019) [Refereed Article] DOI: 10.1111/1440-1681.13208 [eCite] [Details] Citations: Scopus - 5Web of Science - 5 Co-authors: Attrill EH; Ross R; Sutherland BA; Premilovac D Tweet
2019	Bradley EA, Premilovac D, Betik AC, Hu D, Attrill EH, et al., 'Metformin improves vascular and metabolic insulin action in insulin resistant muscle', Journal of Endocrinology, 243, (2) pp. 85-96. ISSN 0022-0795 (2019) [Refereed Article] DOI: 10.1530/JOE-19-0067 [eCite] [Details] Citations: Scopus - 9Web of Science - 10 Co-authors: Bradley EA; Premilovac D; Attrill EH; Keske MA Tweet
2019	Roberts-Thomson KM, Betik AC, Premilovac D, Rattigan S, Richards SM, et al., 'Postprandial microvascular blood flow in skeletal muscle: Similarities and disparities to the hyperinsulinaemic-euglycaemic clamp', Clinical and Experimental Pharmacology and Physiology pp. 1-13. ISSN 0305-1870 (2019) [Refereed Article] DOI: 10.1111/1440-1681.13237 [eCite] [Details] Citations: Scopus - 9Web of Science - 7 Co-authors: Premilovac D; Rattigan S; Ross RM; Keske MA Tweet
2019	Thaver S, Bennett EJ, Foa L, Richards SM, Lyons AB, et al., 'Pregnancy protects against the pro-inflammatory respiratory responses induced by particulate matter exposure', Chemosphere, 225 pp. 796-802. ISSN 0045-6535 (2019) [Refereed Article] DOI: 10.1016/j.chemosphere.2019.03.088 [eCite] [Details] Citations: Scopus - 2Web of Science - 2 Co-authors: Thaver S; Bennett EJ; Foa L; Lyons AB; Zosky GR Tweet
2018	Hu D, Remash D, Russell RD, Greenaway T, Rattigan S, et al., 'Impairments in adipose tissue microcirculation in Type 2 diabetes mellitus assessed by real-time contrast-enhanced ultrasound', Circulation: Cardiovascular Imaging, 11, (4) Article e007074. ISSN 1942-0080 (2018) [Refereed Article] DOI: 10.1161/CIRCIMAGING.117.007074 [eCite] [Details] Citations: Scopus - 13Web of Science - 15 Co-authors: Remash D; Russell RD; Greenaway T; Rattigan S; Squibb KA; Jones G; Premilovac D; Keske MA Tweet
2018	Hu D, Russell RD, Remash D, Greenaway T, Rattigan S, et al., 'Are the metabolic benefits of resistance training in type 2 diabetes linked to improvements in adipose tissue microvascular blood flow?', American Journal of Physiology: Endocrinology and Metabolism, 315, (6) pp. E1242-E1250. ISSN 0193-1849 (2018) [Refereed Article] DOI: 10.1152/ajpendo.00234.2018 [eCite] [Details] Citations: Scopus - 3Web of Science - 3 Co-authors: Russell RD; Remash D; Greenaway T; Rattigan S; Squibb KA; Jones G; Ross RM; Premilovac D; Keske MA Tweet
2018	Premilovac D, Attrill EH, Rattigan S, Richards SM, Kim J, et al., 'Acute, local infusion of angiotensin II impairs microvascular and metabolic insulin sensitivity in skeletal muscle', Cardiovascular Research pp. 1-12. ISSN 0008-6363 (2018) [Refereed Article] DOI: 10.1093/cvr/cvy225 [eCite] [Details] Citations: Scopus - 9Web of Science - 9 Co-authors: Premilovac D; Attrill EH; Rattigan S; Keske MA Tweet
2018	Russell RD, Hu D, Greenaway T, Sharman JE, Rattigan S, et al., 'Oral glucose challenge impairs skeletal muscle microvascular blood flow in healthy people', American Journal of Physiology - Endocrinology and Metabolism, 315, (2) pp. E307-E315. ISSN 0193-1849 (2018) [Refereed Article] DOI: 10.1152/ajpendo.00448.2017 [eCite] [Details] Citations: Scopus - 22Web of Science - 23 Co-authors: Russell RD; Greenaway T; Sharman JE; Rattigan S; Keske MA Tweet
2017	Blackwood SJ, Dwyer RM, Bradley EA, Keske MA, Richards SM, et al., 'Determination of skeletal muscle microvascular flowmotion with contrast-enhanced ultrasound', Ultrasound in Medicine and Biology, 43, (9) pp. 2013-2023. ISSN 0301-5629 (2017) [Refereed Article] DOI: 10.1016/j.ultrasmedbio.2017.05.012 [eCite] [Details] Citations: Scopus - 7Web of Science - 6 Co-authors: Blackwood SJ; Dwyer RM; Bradley EA; Keske MA; Rattigan S Tweet
2017	Keske MA, Dwyer RM, Russell RD, Blackwood SJ, Brown AA, et al., 'Regulation of microvascular flow and metabolism: An overview', Clinical and Experimental Pharmacology and Physiology, 44, (1) pp. 143-149. ISSN 0305-1870 (2017) [Refereed Article] DOI: 10.1111/1440-1681.12688 [eCite] [Details] Citations: Scopus - 20Web of Science - 19 Co-authors: Keske MA; Dwyer RM; Russell RD; Blackwood SJ; Brown AA; Premilovac D; Rattigan S Tweet
2017	Ng HLH, Premilovac D, Rattigan S, Richards SM, Muniyappa R, et al., 'Acute vascular and metabolic actions of the green tea polyphenol epigallocatechin 3-gallate in rat skeletal muscle', Journal of Nutritional Biochemistry, 40 pp. 23-31. ISSN 0955-2863 (2017) [Refereed Article] DOI: 10.1016/j.jnutbio.2016.10.005 [eCite] [Details] Citations: Scopus - 9Web of Science - 9 Co-authors: Ng HLH; Premilovac D; Rattigan S; Keske MA Tweet
2017	Russell RD, Hu D, Greenaway T, Blackwood SJ, Dwyer RM, et al., 'Skeletal muscle microvascular-linked improvements in glycemic control from resistance training in individuals with Type 2 Diabetes', Diabetes Care, 40, (9) pp. 1256-1263. ISSN 0149-5992 (2017) [Refereed Article] DOI: 10.2337/dc16-2750 [eCite] [Details] Citations: Scopus - 46Web of Science - 41 Co-authors: Russell RD; Greenaway T; Blackwood SJ; Dwyer RM; Sharman JE; Jones G; Squibb KA; Brown AA; Otahal P; Al-Aubaidy H; Premilovac D; Hitchins S; Rattigan S; Keske MA Tweet
2016	Keske MA, Premilovac D, Bradley EA, Dwyer RM, Richards SM, et al., 'Muscle microvascular blood flow responses in insulin resistance and ageing', The Journal of Physiology, 594, (8) pp. 2223-2231. ISSN 1469-7793 (2016) [Refereed Article] DOI: 10.1113/jphysiol.2014.283549 [eCite] [Details] Citations: Scopus - 45Web of Science - 47 Co-authors: Keske MA; Premilovac D; Bradley EA; Dwyer RM; Rattigan S Tweet
2015	Bradley EA, Zhang L, Genders AJ, Richards SM, Rattigan S, et al., 'Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside', Cardiovascular Diabetology, 14, (1) Article 91. ISSN 1475-2840 (2015) [Refereed Article] DOI: 10.1186/s12933-015-0251-y [eCite] [Details] Citations: Scopus - 6Web of Science - 6 Co-authors: Bradley EA; Rattigan S; Keske MA Tweet
2014	Premilovac D, Richards SM, Rattigan S, Keske MA, 'A vascular mechanism for high-sodium-induced insulin resistance in rats', Diabetologia: Clinical and Experimental Diabetes and Metabolism, 57, (12) pp. 2586-2595. ISSN 0012-186X (2014) [Refereed Article] DOI: 10.1007/s00125-014-3373-y [eCite] [Details] Citations: Scopus - 24Web of Science - 24 Co-authors: Premilovac D; Rattigan S; Keske MA Tweet
2013	Bradley EA, Richards SM, Keske MA, Rattigan S, 'Local NOS inhibition impairs vascular and metabolic actions of insulin in rat hindleg muscle in vivo', American Journal of Physiology: Endocrinology and Metabolism, 305, (6) pp. E745-E750. ISSN 0193-1849 (2013) [Refereed Article] DOI: 10.1152/ajpendo.00289.2013 [eCite] [Details] Citations: Scopus - 29Web of Science - 28 Co-authors: Bradley EA; Keske MA; Rattigan S Tweet
2013	Premilovac D, Bradley EA, Ng HLH, Richards SM, Rattigan S, et al., 'Muscle insulin resistance resulting from impaired microvascular insulin sensitivity in Sprague Dawley rats', Cardiovascular Research, 98, (1) pp. 28-36. ISSN 0008-6363 (2013) [Refereed Article] DOI: 10.1093/cvr/cvt015 [eCite] [Details] Citations: Scopus - 33Web of Science - 31 Co-authors: Premilovac D; Bradley EA; Ng HLH; Rattigan S; Keske MA Tweet
2013	Premilovac D, Roberts-Thompson KM, Ng HLH, Bradley EA, Richards SM, et al., 'Blueberry tea enhances insulin sensitivity by augmenting insulin-mediated metabolic and microvascular responses in skeletal muscle of high fat fed rats', International Journal of Diabetology & Vascular Disease Research, 1, (8) pp. 1-10. ISSN 2328-353X (2013) [Non Refereed Article] [eCite] [Details] Co-authors: Premilovac D; Ng HLH; Bradley EA; Rattigan S; Keske MA Tweet
2013	Rattigan S, Richards SM, Keske MA, 'Microvascular contributions to insulin resistance', Diabetes, 62, (2) pp. 343-345. ISSN 0012-1797 (2013) [Contribution to Refereed Journal] DOI: 10.2337/db12-1193 [eCite] [Details] Citations: Scopus - 11Web of Science - 11 Co-authors: Rattigan S; Keske MA Tweet
2012	St-Pierre P, Keith LJ, Richards SM, Rattigan S, Keske MA, 'Microvascular blood flow responses to muscle contraction are not altered by high-fat feeding in rats', Diabetes, Obesity and Metabolism, 14, (8) pp. 753-761. ISSN 1462-8902 (2012) [Refereed Article] DOI: 10.1111/j.1463-1326.2012.01598.x [eCite] [Details] Citations: Scopus - 15Web of Science - 16 Co-authors: Keith LJ; Rattigan S; Keske MA Tweet
2011	Bussey CT, Kolka CM, Rattigan S, Richards SM, 'Adiponectin opposes endothelin-1-mediated vasoconstriction in the perfused rat hindlimb', American Journal of Physiology: Heart and Circulatory Physiology, 301, (1) pp. H79-H86. ISSN 0363-6135 (2011) [Refereed Article] DOI: 10.1152/ajpheart.00864.2010 [eCite] [Details] Citations: Scopus - 19Web of Science - 21 Co-authors: Bussey CT; Kolka CM; Rattigan S Tweet
2011	Genders AJ, Bradley EA, Rattigan S, Richards SM, 'cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle', American Journal of Physiology: Endocrinology and Metabolism, 301, (2) pp. E342-E350. ISSN 0193-1849 (2011) [Refereed Article] DOI: 10.1152/ajpendo.00691.2010 [eCite] [Details] Citations: Scopus - 19Web of Science - 18 Co-authors: Genders AJ; Bradley EA; Rattigan S Tweet
2010	St Pierre P, Genders AJ, Keske MA, Richards SM, Rattigan S, 'Loss of insulin-mediated microvascular perfusion in skeletal muscle is associated with the development of insulin resistance ', Diabetes Obesity & Metabolism, 12, (9) pp. 798-805. ISSN 1462-8902 (2010) [Refereed Article] DOI: 10.1111/j.1463-1326.2010.01235.x [eCite] [Details] Citations: Scopus - 32Web of Science - 30 Co-authors: Genders AJ; Keske MA; Rattigan S Tweet
2009	McLean SR, Richards SM, Cover S, Brandon S, Davies NW, et al., 'Papyriferic Acid, an antifeedant triterpene from birch trees, inhibits succinate dehydrogenase from liver mitochondria', Journal of Chemical Ecology, 35, (10) pp. 1252-1261. ISSN 0098-0331 (2009) [Refereed Article] DOI: 10.1007/s10886-009-9702-9 [eCite] [Details] Citations: Scopus - 18Web of Science - 16 Co-authors: McLean SR; Cover S; Brandon S; Davies NW Tweet
2009	Newman JMB, Dwyer RM, St Pierre P, Richards SM, Clark MG, et al., 'Decreased microvascular vasomotion and myogenic response in rat skeletal muscle in association with acute insulin resistance', Journal of Physiology, 587, (11) pp. 2579-2588. ISSN 0022-3751 (2009) [Refereed Article] DOI: 10.1113/jphysiol.2009.169011 [eCite] [Details] Citations: Scopus - 65Web of Science - 56 Co-authors: Newman JMB; Dwyer RM; Clark MG; Rattigan S Tweet
2008	Dwyer T, Blizzard L, Patterson B, Ponsonby A-L, Martin K, et al., 'Association between birth weight and adolescent systolic blood pressure in a caucasian birth cohort differs according to skin type, CRH promoter or 11β-HSD2 genotype', Archives of Disease in Childhood, 93, (9) pp. 760-767. ISSN 0003-9888 (2008) [Refereed Article] DOI: 10.1136/adc.2007.129122 [eCite] [Details] Citations: Scopus - 3Web of Science - 3 Co-authors: Dwyer T; Blizzard L; Patterson B; Ponsonby A-L; Martin K; Quinn S; Sale MM; Dickinson JL Tweet
2008	Ponsonby AL, Blizzard CL, Pezic A, Cochrane JA, Ellis JA, et al., 'Adiposity Gain During Childhood, ACE I/D Polymorphisms and Metabolic Outcomes', Obesity, 16, (9) pp. 2141-2147. ISSN 1930-7381 (2008) [Refereed Article] DOI: 10.1038/oby.2008.302 [eCite] [Details] Citations: Scopus - 14Web of Science - 11 Co-authors: Ponsonby AL; Blizzard CL; Cochrane JA; Dickinson JL; Sale MM; Dwyer T Tweet
2008	Ross RM, Downey KA, Newman JMB, Richards SM, Clark MG, et al., 'Contrast-enhanced ultrasound measurement of microvascular perfusion relevant to nutrient and hormone delivery in skeletal muscle: A model study in vitro', Microvascular Research, 75, (3) pp. 323-329. ISSN 0026-2862 (2008) [Refereed Article] DOI: 10.1016/j.mvr.2007.11.002 [eCite] [Details] Citations: Scopus - 12Web of Science - 11 Co-authors: Ross RM; Downey KA; Newman JMB; Clark MG; Rattigan S Tweet
2007	Kolka CM, Rattigan S, Richards SM, Clark MG, 'Potential for endothelin-1-mediated impairment of contractile activity in hypertension', Clinical and Experimental Physiology and Pharmacology, 34, (3) pp. 217-222. ISSN 0305-1870 (2007) [Refereed Article] DOI: 10.1111/j.1440-1681.2007.04575.x [eCite] [Details] Citations: Scopus - 1Web of Science - 5 Co-authors: Kolka CM; Rattigan S; Clark MG Tweet
2007	Newman JMB, Ross RM, Richards SM, Clark MG, Rattigan S, 'Insulin and contraction increase nutritive blood flow in rat muscle in vivo: determined by microdialysis of L-[14C]glucose', Journal of Physiology, 585, (1) pp. 217-229. ISSN 0022-3751 (2007) [Refereed Article] DOI: 10.1113/jphysiol.2007.138818 [eCite] [Details] Citations: Scopus - 15Web of Science - 14 Co-authors: Newman JMB; Ross RM; Clark MG; Rattigan S Tweet
2007	Rattigan S, Bussey CT, Ross RM, Richards SM, 'Obesity, Insulin Resistance, and Capillary Recruitment', Microcirculation, 14, (4-5) pp. 299-309. ISSN 1073-9688 (2007) [Refereed Article] DOI: 10.1080/10739680701282796 [eCite] [Details] Citations: Scopus - 26Web of Science - 24 Co-authors: Rattigan S; Bussey CT; Ross RM Tweet
2007	Vollus GC, Bradley EA, Roberts NK, Newman JMB, Richards SM, et al., 'Graded occlusion of perfused rat muscle vasculature decreases insulin action', Clinical Science, 112, (8) pp. 457-466. ISSN 0143-5221 (2007) [Refereed Article] DOI: 10.1042/CS20060311 [eCite] [Details] Citations: Scopus - 16Web of Science - 13 Co-authors: Vollus GC; Bradley EA; Roberts NK; Newman JMB; Rattigan S; Clark MG Tweet
2006	Mahajan H, Kolka CM, Newman JMB, Rattigan S, Richards SM, et al., 'Vascular and metabolic effects of methacholine in relation to insulin action in muscle', Diabetologia, 49, (4) pp. 713-723. ISSN 0012-186X (2006) [Refereed Article] DOI: 10.1007/s00125-005-0110-6 [eCite] [Details] Citations: Scopus - 4Web of Science - 3 Co-authors: Mahajan H; Kolka CM; Newman JMB; Rattigan S; Clark MG Tweet
2006	Rattigan S, Bradley EA, Richards SM, Clark MG, 'Muscle metabolism and control of capillary blood flow: insulin and exercise', Essays in Biochemistry, 42, (1) pp. 133-144. ISSN 0071-1365 (2006) [Refereed Article] DOI: 10.1042/bse0420133 [eCite] [Details] Citations: Scopus - 9Web of Science - 8 Co-authors: Rattigan S; Bradley EA; Clark MG Tweet
2006	Rattigan S, Zhang L, Mahajan H, Kolka CM, Richards SM, et al., 'Factors influencing the hemodynamic and metabolic effects of insulin in muscle', Current Diabetes Reviews, 2, (1) pp. 61-70. ISSN 1573-3998 (2006) [Refereed Article] DOI: 10.2174/157339906775473653 [eCite] [Details] Citations: Scopus - 8 Co-authors: Rattigan S; Zhang L; Mahajan H; Kolka CM; Clark MG Tweet
2005	Domenighetti AA, Wang Q, Egger M, Richards SM, Pedrazzini T, et al., 'Angiotensin II-mediated phenotypic cardiomyocyte remodeling leads to age-dependent cardiac dysfunction and failure', Hypertension, 46, (2) pp. 426-432. ISSN 0194-911X (2005) [Refereed Article] DOI: 10.1161/01.HYP.0000173069.53699.d9 [eCite] [Details] Citations: Scopus - 86Web of Science - 79 Tweet
2005	Kolka CM, Rattigan S, Richards SM, Barrett EJ EJ, Clark MG, 'Endothelial Na+ -D-glucose cotransporter: No Role in Insulin-mediated Glucose Uptake ', Hormone and Metabolic Research, 37, (11) pp. 657-661. ISSN 0018-5043 (2005) [Refereed Article] DOI: 10.1055/s-2005-870574 [eCite] [Details] Citations: Scopus - 2Web of Science - 2 Co-authors: Kolka CM; Rattigan S; Clark MG Tweet
2005	Kolka CM, Rattigan S, Richards SM, Clark MG, 'Metabolic and vascular actions of endothelin-1 are inhibited by insulin-mediated vasodilation in perfused rat hindlimb muscle', British Journal of Pharmacology, 145, (7) pp. 992-1000. ISSN 0007-1188 (2005) [Refereed Article] DOI: 10.1038/sj.bjp.0706263 [eCite] [Details] Citations: Scopus - 16Web of Science - 17 Co-authors: Kolka CM; Rattigan S; Clark MG Tweet
2005	Rattigan S, Wheatley C, Richards SM, Barrett EJ, Clark MG, 'Exercise and insulin-mediated capillary recruitment in muscle', Exercise and Sport Sciences Reviews, 33, (1) pp. 43-48. ISSN 0091-6331 (2005) [Refereed Article] PMID: 15640720 [eCite] [Details] Citations: Scopus - 27Web of Science - 30 Co-authors: Rattigan S Tweet
2005	Wallis MG, Smith ME, Kolka CM, Zhang L, Richards SM, et al., 'Acute glucosamine-induced insulin resistance in muscle in vivo is associated with impaired capillary recruitment', Diabetologia, 48, (10) pp. 2131-2139. ISSN 0012-186X (2005) [Refereed Article] DOI: 10.1007/s00125-005-1887-z [eCite] [Details] Citations: Scopus - 31Web of Science - 27 Co-authors: Smith ME; Kolka CM; Zhang L; Rattigan S; Clark MG Tweet
2005	Zhang L, Newman JMB, Richards SM, Rattigan S, Clark MG, 'Microvascular flow routes in muscle controlled by vasoconstrictors', Microvascular Research, 70, (1) pp. 7-16. ISSN 0026-2862 (2005) [Refereed Article] DOI: 10.1016/j.mvr.2005.06.001 [eCite] [Details] Citations: Scopus - 13Web of Science - 11 Co-authors: Zhang L; Newman JMB; Rattigan S; Clark MG Tweet
2004	Mahajan H, Richards SM, Rattigan S, Clark MG, 'Local methacholine but not bradykinin potentiates insulin-mediated capillary recruitment and glucose uptake in muscle in vivo', Diabetologia, 47, (12) pp. 2226-2234. ISSN 0012-186X (2004) [Refereed Article] DOI: 10.1007/s00125-004-1580-7 [eCite] [Details] Citations: Scopus - 20Web of Science - 17 Co-authors: Mahajan H; Rattigan S; Clark MG Tweet
2004	Wheatley CM, Rattigan S, Richards SM, Barrett EJ, Clark MG, 'Skeletal muscle contraction stimulates capillary recruitment and glucose uptake in insulin resistant obese Zucker rats', American Journal of Physiology - Endocrinology and Metabolism, 287, (4) pp. E804-E807. ISSN 0193-1849 (2004) [Refereed Article] DOI: 10.1152/ajpendo.00077.2004 [eCite] [Details] Citations: Scopus - 51Web of Science - 53 Co-authors: Rattigan S; Clark MG Tweet
2004	Zhang L, Vincent MA, Richards SM, Clerk LH, Rattigan S, et al., 'Insulin sensitivity of muscle capillary recruitment in vivo', Diabetes, 53, (2) pp. 447-453. ISSN 0012-1797 (2004) [Refereed Article] DOI: 10.2337/diabetes.53.2.447 [eCite] [Details] Citations: Scopus - 143Web of Science - 135 Co-authors: Zhang L; Vincent MA; Rattigan S; Clark MG Tweet
2003	Clark MG, Wallis MG, Barrett EJ, Vincent MA, Richards SM, et al., 'Blood flow and muscle metabolism: a focus on insulin action', American Journal of Physiology: Endocrinology and Metabolism, 284, (2) pp. E241-E258. ISSN 0193-1849 (2003) [Refereed Article] DOI: 10.1152/ajpendo.00408.2002 [eCite] [Details] Citations: Web of Science - 276 Co-authors: Clark MG; Vincent MA; Rattigan S Tweet
2003	Mahajan H, Richards SM, Rattigan S, Clark MG, 'T-1032, a cyclic GMP phosphodiesterase-5 inhibitor, acutely blocks physiologic insulin-mediated muscle haemodynamic effects and glucose uptake in vivo', British Journal of Pharmacology, 140, (7) pp. 1283-1291. ISSN 0007-1188 (2003) [Refereed Article] DOI: 10.1038/sj.bjp.0705548 [eCite] [Details] Citations: Scopus - 8Web of Science - 7 Co-authors: Mahajan H; Rattigan S; Clark MG Tweet
2003	Zhang L, Wheatley CM, Richards SM, Barrett EJ, Clark MG, et al., 'TNFalpha acutely inhibits vascular effects of physiological but not high insulin or contraction', American Journal of Physiology: Endocrinology and Metabolism, 285, (3 ) pp. E654-E660. ISSN 0193-1849 (2003) [Refereed Article] DOI: 10.1152/ajpendo.00119.2003 [eCite] [Details] Citations: Scopus - 51Web of Science - 50 Co-authors: Zhang L; Clark MG; Rattigan S Tweet

Chapter in Book

(1 outputs)

Year	Citation	Altmetrics
2013	Premilovac D, Ng HLH, Richards SM, Bradley EA, Dwyer RM, et al., 'Role for the Microvasculature in Glucose Uptake in Skeletal Muscle', Glucose Uptake: Regulation, Signaling Pathways and Health Implications (Endocrinology Research and Clinical Developments), Nova Science Publishers, Johnson CC and Williams DB (ed), New York, pp. 109-139. ISBN 978-1-62618-670-5 (2013) [Research Book Chapter] [eCite] [Details] Co-authors: Premilovac D; Ng HLH; Bradley EA; Dwyer RM; Rattigan S; Keske MA Tweet

Year

Citation

Altmetrics

2013

Premilovac D, Ng HLH, Richards SM, Bradley EA, Dwyer RM, et al., 'Role for the Microvasculature in Glucose Uptake in Skeletal Muscle', Glucose Uptake: Regulation, Signaling Pathways and Health Implications (Endocrinology Research and Clinical Developments), Nova Science Publishers, Johnson CC and Williams DB (ed), New York, pp. 109-139. ISBN 978-1-62618-670-5 (2013) [Research Book Chapter]

[eCite] [Details]

Co-authors: Premilovac D; Ng HLH; Bradley EA; Dwyer RM; Rattigan S; Keske MA

Conference Publication

(24 outputs)

Year	Citation	Altmetrics
2016	Hu Donghua, Russell RD, Sharman JE, Rattigan S, Jacobson GA, et al., 'Effect of blueberry tea on improving metabolic and vascular function in people with and without type 2 diabetes - A Pilot Study', Australian Diabetes Society and Australian Diabetes Educators Association Annual Scientific Meeting 2016, 24-26 August, 2016, Gold Coast, Australia (2016) [Conference Extract] [eCite] [Details] Co-authors: Russell RD; Sharman JE; Rattigan S; Jacobson GA; Al-Aubaidy HAM; Keske MAV
2011	Newman JMB, Dwyer RM, Keske MAV, Richards SM, Rattigan S, 'Flow motion in skeletal muscle is associated with increased nutritive flow and insulin action', Proceedings of the 71st Scientific Sessions of the American Diabetes Association, 24-28 June, San Diego, California, pp. 1740-P. (2011) [Conference Extract] [eCite] [Details] Co-authors: Newman JMB; Dwyer RM; Keske MAV; Rattigan S
2006	Clark MG, Dwyer RM, Newman JMB, Richards SM, Rattigan S, 'A comparison of ultrasound and laser Doppler for Measuring Capillary Recruitment Using Models in vitro', Proceedings, 27-30 September, 2006, Indianapolis, pp. 10. (2006) [Conference Extract] [eCite] [Details] Co-authors: Clark MG; Dwyer RM; Newman JMB; Rattigan S
2006	Dwyer RM, Newman JMB, Richards SM, Rattigan S, Clark MG, 'Laser Doppler flowmetry, but not contrast enhanced ultrasound, influenced by flow when measuring changes in muscle capillary recruitment - a study in vitro', Proceedings of Meeting, 13th September, 2006, Copenhagen, pp. 16. (2006) [Conference Extract] [eCite] [Details] Co-authors: Dwyer RM; Newman JMB; Rattigan S; Clark MG
2006	Genders AJ, Rattigan S, Clark MG, Richards SM, 'cGMP degrading phosphodiesterases are expressed differentially in skeletal muscle vasculature', Diabetes, vol 55, Supplement 1, 9-13 June, 2006, Washington, pp. A333. ISSN 0012-1797 (2006) [Conference Extract] [eCite] [Details] Co-authors: Genders AJ; Rattigan S; Clark MG
2006	Genders AJ, Rattigan S, Clark MG, Richards SM, 'Differential expression of cGMP degrading phosphodiesterases in skeletal muscle vasculature', Proceedings, 24-28 September, 2006, Brisbane, pp. 130. ISSN 1328-4924 (2006) [Conference Extract] [eCite] [Details] Co-authors: Genders AJ; Rattigan S; Clark MG
2006	Newman JMB, Clark MG, Dwyer RM, Richards SM, Rattigan S, 'Use of microdialysis to assess capillary recruitment in muscle - a study in vitro', Proceedings of Meeting, 13th September, 2006, Copenhagen, pp. 17. (2006) [Conference Extract] [eCite] [Details] Co-authors: Newman JMB; Clark MG; Dwyer RM; Rattigan S
2005	Clark MG, Wallis MG, Smith ME, Kolka CM, Zhang L, et al., 'Glucosamine induces acute insulin resistance in muscle in vivo assocaited with impaired capillary recruitment', Diabetologia, 48 (S1), 10-15 September, 2005, Athens, pp. A210. ISSN 0012-186X (2005) [Conference Extract] [eCite] [Details] Co-authors: Clark MG; Smith ME; Kolka CM; Zhang L; Rattigan S
2005	Kolka CM, Rattigan S, Richards SM, Clark MG, 'Endothelin-1 vascular and resultant metabolic actions in perfused rat hindlimb are opposed by insulin', Diabetologia, vol 48, Supplement 1, 10-15 September, 2005, Athens, pp. A230. ISSN 0012-186X (2005) [Conference Extract] [eCite] [Details] Co-authors: Kolka CM; Rattigan S; Clark MG
2005	Mahajan H, Richards SM, Rattigan S, Clark MG, 'Local infusion of an inhibitor of Ca²⁺ dependent K⁺ channels (TEA), but not L-NAME blocks insulin-mediated capillary recruitment and glucose uptake in muscle in vivo', Diabetes, Vol 54, Supplement 1, June 10-14, 2005, San Diego, pp. A379. ISSN 0012-1797 (2005) [Conference Extract] [eCite] [Details] Co-authors: Mahajan H; Rattigan S; Clark MG
2005	Vollus GC, Newman JMB, Richards SM, Barrett EJ, Rattigan S, 'Partial microsphere embolism of muscle leads to acute impairment of insulin-mediated glucose uptake without compromising resting energetics', Diabetes, Vol 54, Supplement 1, June 10-14, 2005, San Diego, pp. A379. ISSN 0012-1797 (2005) [Conference Extract] [eCite] [Details] Co-authors: Vollus GC; Newman JMB; Rattigan S
2005	Wheatley CM, O'Farrell GM, Richards SM, Smith S, Clark MG, 'Rosiglitazone partly reverses insulin resistance in the obese Zucker rat but fails to recover insulin-mediated capillary recruitment and glucose uptake in muscle', Diabetes, Vol 54, Supplement 1, June 10-14, 2005, San Diego, pp. A642. ISSN 0012-1797 (2005) [Conference Extract] [eCite] [Details] Co-authors: O'Farrell GM; Clark MG
2004	Kolka CM, Rattigan S, Richards SM, Clark MG, 'Endothelin-1 as a messenger for insulin has both stimulatory and inhibitory effects on perfused muscle metabolism via its vascular actions', Diabetes, Vol 53, Supplement 2, June 4-8, 2004, Orlando, pp. A368. ISSN 0012-1797 (2004) [Conference Extract] [eCite] [Details] Co-authors: Kolka CM; Rattigan S; Clark MG
2004	Mahajan H, Richards SM, Rattigan S, Clark MG, 'Local methacholine but not bradykinin potentiates insulin-mediated capillary recruitment and glucose uptake in muscle in vivo', Diabetes, Vol 53, Supplement 2, June 4-8, 2004, Orlando, pp. A369. ISSN 0012-1797 (2004) [Conference Extract] [eCite] [Details] Co-authors: Mahajan H; Rattigan S; Clark MG
2004	Steinberg GR, Dwyer RM, Carey AL, Rogers S, Richards SM, et al., 'Interleukin-6 increases glucose uptake but does not increase AMPK activity in L6 myotubes and perfused rat hindlimb', Proceedings of AMPK Meeting, 23-26 March, 2004, Lorne, pp. 126. (2004) [Conference Extract] [eCite] [Details] Co-authors: Dwyer RM; Rattigan S; Clark MG
2004	Wheatley CM, Barrett EJ, Bradley EA, Richards SM, Clark MG, et al., 'Muscle capillary recruitment and glucose uptake of genetically obese rats respond to contractions but not insulin', Diabetes, Vol 53, Supplement 2, June 4-8, 2004, Orlando, pp. A371. ISSN 0012-1797 (2004) [Conference Extract] [eCite] [Details] Co-authors: Bradley EA; Clark MG; Rattigan S
2004	Wheatley CM, Richards SM, Clark MG, Barrett EJ, Rattigan S, 'Role of capillary recruitment in the potentiation of insulin action by prior exercise', Diabetes, Vol 53, Supplement 2, June 4-8, 2004, Orlando, pp. A28. ISSN 0012-1797 (2004) [Conference Extract] [eCite] [Details] Co-authors: Clark MG; Rattigan S
2003	Bradley EA, Zhang L, Newman JMB, Richards SM, Clark MG, et al., 'Acute divergent effects of AICAR on insulin action in vivo', Diabetes, Vol 52, Supplement 1, June 13-17, 2003, New Orleans, pp. A344. ISSN 0012-1797 (2003) [Conference Extract] [eCite] [Details] Co-authors: Bradley EA; Zhang L; Newman JMB; Clark MG; Rattigan S
2003	Mahajan H, Richards SM, Rattigan S, Clark MG, 'T-1032 a cyclic GMP phosphodiesterase-5 inhibitor blocks physiologic insulin-mediated muscle hemodynamic effects and glucose uptake in vivo', Diabetes, Vol 52, Supplement 1, June 13-17, 2003, New Orleans, pp. A541. ISSN 0012-1797 (2003) [Conference Extract] [eCite] [Details] Co-authors: Mahajan H; Rattigan S; Clark MG
2003	Richards SM, Wheatley CM, Zhang L, Rattigan S, Barrett EJ, et al., 'Contraction-mediated muscle capillary recruitment and metabolic responses in vivo are resistant to TNFα', Diabetologia, Vol 46, Supplement 2, 24-29 August, 2003, Paris, pp. A58. ISSN 0012-186X (2003) [Conference Extract] [eCite] [Details] Co-authors: Zhang L; Rattigan S; Clark MG
2003	Zhang L, Richards SM, Rattigan S, Barrett EJ, Clark MG, 'Capillary recruitment in muscle is a highly sensitive event in insulin action in vivo', Diabetes, Vol 52, Supplement 1, June 13-17, 2003, New Orleans, pp. A48. ISSN 0012-1797 (2003) [Conference Extract] [eCite] [Details] Co-authors: Zhang L; Rattigan S; Clark MG
2002	Wheatley CM, Bradley EA, Wallis MG, Rattigan S, Richards SM, et al., 'Contraction-mediated capillary recruitment is not impaired in muscle of insulin-resistant obese Zucker rats', Diabetes, Vol 51, Supplement 2, June 14-18, 2002, San Francisco, pp. A564. ISSN 0012-1797 (2002) [Conference Extract] [eCite] [Details] Co-authors: Bradley EA; Rattigan S; Clark MG
2002	Zhang L, Rattigan S, Richards SM, Clark MG, 'TNF? inhibits low physiologic but not high insulin-mediated capillary recruitment and glucose uptake in vivo', Diabetes, Vol 51, Supplement 2, June 14-18, 2002, San Francisco, pp. A565. ISSN 0012-1797 (2002) [Conference Extract] [eCite] [Details] Co-authors: Zhang L; Rattigan S; Clark MG
2001	Clark MG, Barrett EJ, Richards SM, Clark ADH, Rattigan S, 'Microvascular involvement in insulin resistance of skeletal muscle', Proceedings of the 7th World Congress for Microcirculation, August 19-22, 2001, Sydney, pp. 31-37. (2001) [Non Refereed Conference Paper] [eCite] [Details] Co-authors: Clark MG; Clark ADH; Rattigan S

Grants & Funding

Funding Summary

Number of grants

Total funding

$3,349,795

Projects

Understanding how breathing in air pollution leads to metabolic disease (2023)$24,958

Description: Exposure to air pollution is becoming recognised as a major risk factor for development of type 2 diabetes, particularly in people that are overweight or obese. Our study aims to understand if exposure to traffic pollution or wood fire smoke triggers development of insulin resistance, commonly known as pre-diabetes.Original title: Could particulate air pollution be contributing to the rise in development of Type 2 Diabetes?
Funding: Royal Hobart Hospital Research Foundation ($24,958)
Scheme: Grant-Project
Administered By: University of Tasmania
Research Team: Premilovac D; Richards SM; Zosky GR; Burgess JR
Year: 2023

Role of microvascular flowmotion in skeletal muscle glucose metabolism (2013 - 2015)$576,533

Description: Obesity and type 2 diabetes are nationally and globally reaching epidemic rates. This project investigates the regulation of blood flow within muscle and its impact on metabolism. Outcomes from the study may lead to diagnostic tools and treatments for cardiovascular disease associated with obesity, hypertension and type 2 diabetes.
Funding: National Health & Medical Research Council ($576,533)
Scheme: Grant-Project
Administered By: University of Tasmania
Research Team: Rattigan S; Keske MAV; Richards SM; Ross RM
Period: 2013 - 2015
Grant Reference: 1043474_HF

Adipose tissue blood flow: the link between obesity and disease risk? (2012)$7,580

Funding: The Select Foundation ($7,580)
Scheme: Grant-Small Grants Scheme
Administered By: University of Tasmania
Research Team: Richards SM; Keske MAV
Year: 2012

Microvascular Defects and Insulin Resistance (2011 - 2012)$127,490

Funding: Heart Foundation ($127,490)
Scheme: Grant-In-Aid
Administered By: University of Tasmania
Research Team: Rattigan S; Keske MAV; Richards SM
Period: 2011 - 2012

NHMRC Standard Equipment Grant - 2008 (2008)$72,611

Funding: National Health & Medical Research Council ($72,611)
Scheme: Grant-Equipment
Administered By: University of Tasmania
Research Team: Keske MAV; Rattigan S; Richards SM
Year: 2008
Grant Reference: 580023

Interaction between adiponectin and insulin in vascular control of glucose uptake in muscle (2008 - 2009)$119,574

Funding: Heart Foundation ($119,574)
Scheme: Grant-In-Aid
Administered By: University of Tasmania
Research Team: Rattigan S; Richards SM
Period: 2008 - 2009

Central and Peripheral Actions of Insulin for the Control of Muscle Capillary Recruitment (2007 - 2009)$417,750

Funding: National Health & Medical Research Council ($417,750)
Scheme: Grant-Project
Administered By: University of Tasmania
Research Team: Clark MG; Rattigan S; Richards SM; Choi-Lundberg DL
Period: 2007 - 2009
Grant Reference: 457603

Endothelin-1, type2 diabetes and hypertension (2007 - 2008)$112,680

Funding: Heart Foundation ($112,680)
Scheme: Grant-In-Aid
Administered By: University of Tasmania
Research Team: Clark MG; Rattigan S; Richards SM; Kolka CM
Period: 2007 - 2008

The Effects of Insulin on the Microvasculature (2006 - 2010)$347,499

Funding: National Institutes of Health ($347,499)
Scheme: Grant
Administered By: University of Virginia
Research Team: Clark MG; Rattigan S; Richards SM
Period: 2006 - 2010

Isoelectric Focussing System (2006)$15,080

Funding: National Health & Medical Research Council ($15,080)
Scheme: Grant-Equipment
Administered By: University of Tasmania
Research Team: Richards SM; Rattigan S
Year: 2006
Grant Reference: 361670

Nutrient and Hormone Delivery to Muscle: Interactions between Insulin and Exercise (2005 - 2007)$299,500

Funding: National Health & Medical Research Council ($299,500)
Scheme: Grant-Project Three Year
Administered By: University of Tasmania
Research Team: Clark MG; Rattigan S; Richards SM
Period: 2005 - 2007
Grant Reference: 352600

Leica DMIRB Inverted Microscope Configured for Fluorescence and Bright Field with Phase Contrast (2005)$10,000

Funding: National Health & Medical Research Council ($10,000)
Scheme: Grant-Equipment
Administered By: University of Tasmania
Research Team: Chuah MI; West AK; Holloway AF; Rattigan S; Richards SM; Chung RS; Foa LC
Year: 2005
Grant Reference: 264668

Ultrasound in Muscle Vascular Research, Diagnosis and Gene Therapy (2004 - 2006)$285,000

Funding: Australian Research Council ($285,000)
Scheme: Grant-Discovery Projects
Administered By: University of Tasmania
Research Team: Clark MG; Richards SM
Period: 2004 - 2006
Grant Reference: DP0449669

Muscle Vascular Research and Gene Therapy Using Ultrasound (2004)$142,900

Funding: Australian Research Council ($102,900)
Collaborators: Deakin University ($10,000); Royal Melbourne Institute of Technology University ($10,000); University of Melbourne ($10,000); University of New South Wales ($10,000)
Scheme: Grant-Linkage Infrastructure
Administered By: University of Tasmania
Research Team: Clark MG; Rattigan S; Richards SM
Year: 2004
Grant Reference: LE0452281

Refrigerated Benchtop Centrifuge (2004)$12,941

Funding: National Health & Medical Research Council ($12,941)
Scheme: Grant-Equipment
Administered By: University of Tasmania
Research Team: Holloway AF; West AK; Chuah MI; Rattigan S; Richards SM
Year: 2004
Grant Reference: 264536

Gradient Thermal Cycler for PCR (2004)$7,055

Funding: National Health & Medical Research Council ($7,055)
Scheme: Grant-Equipment
Administered By: University of Tasmania
Research Team: Richards SM; Rattigan S
Year: 2004
Grant Reference: 264536

Augmenting Microvascular Blood Flow in Muscle (2003 - 2005)$210,000

Funding: National Health & Medical Research Council ($210,000)
Scheme: Grant-Project Three Year
Administered By: University of Tasmania
Research Team: Clark MG; Richards SM; Rattigan S
Period: 2003 - 2005
Grant Reference: 253900

Relationship Between Muscle Insulin Resistance and High Blood Pressure (2003 - 2004)$90,000

Funding: Heart Foundation ($90,000)
Scheme: Grant-In-Aid
Administered By: University of Tasmania
Research Team: Clark MG; Rattigan S; Richards SM
Period: 2003 - 2004

Genetic Factors that Predispose Low Birth Weight Babies to Increased Risk of Hypertension and IGT (2002 - 2003)$95,000

Funding: National Health & Medical Research Council ($95,000)
Scheme: Grant-Project Three Year
Administered By: University of Tasmania
Research Team: Dwyer T; Sale MM; Richards SM; Morley R; Rich S; Blizzard CL
Period: 2002 - 2003
Grant Reference: 211309

A Novel Form of Resting Muscle Thermogenesis from Na+ Cycling Regulated by Signals from Blood Vessels (2001 - 2003)$201,530

Funding: Australian Research Council ($201,530)
Scheme: Grant-Large
Administered By: University of Tasmania
Research Team: Clark MG; Richards SM
Period: 2001 - 2003
Grant Reference: A00105049

Detrimental Haemodynamic Changes in Skeletal Muscle From Chronic Heart Failure (2001 - 2002)$68,400

Funding: Heart Foundation ($68,400)
Scheme: Grant-In-Aid
Administered By: University of Tasmania
Research Team: Clark MG; Rattigan S; Richards SM
Period: 2001 - 2002

Development of Laser Doppler Flowmetry for Assessment of Muscle Microvascular Flow in Insulin Resistance (2000)$32,200

Funding: Clifford Craig Foundation ($32,200)
Scheme: Grant
Administered By: University of Tasmania
Research Team: Clark MG; Rattigan S; Richards SM; Clark ADH
Year: 2000

The Role of Nutritive and Non-nutritive Blood Flow on Lipid Clearance by Normal and Insulin-resistant Muscle (1999 - 2000)$73,514

Funding: Heart Foundation ($73,514)
Scheme: Grant-In-Aid
Administered By: University of Tasmania
Research Team: Clark MG; Rattigan S; Richards SM
Period: 1999 - 2000

Research Supervision

During my career I have co-authored 92 meeting presentations and 58 peer-reviewed publications (12 since 2009), including Circulation [IF 14.43], PNAS [IF 9.77], Diabetes [IF 8.89], Hypertension [IF 6.91], and J Cell Sci [IF 6.29]. My work has been cited 1330 times, and I have an h-index of 20.

Current

Completed

Current

Degree	Title	Commenced
PhD	Responsiveness of In Vitro and In Vivo Skeletal Muscle Pericytes to Circulating and Muscle-Derived Paracrine Vasoactive Molecules	2018

Completed

Degree	Title	Completed
PhD	The Early Life Effects of Maternal Exposure to Particulate Matter Candidate: Santon Thaver	2021
PhD	Role of Adipose Tissue Microvascular Blood Flow in Type 2 Diabetes Candidate: Donghua Hu	2018
PhD	Inflammation is Not a Contributing Factor in the Development of Insulin Resistance in Diet Induced Obesity in Rats Candidate: Aascha Adriana Brown	2017
PhD	Characterisation of Flowmotion in Healthy Controls and Type 2 Diabetes Candidate: Sarah Joan Blackwood	2017
PhD	Effect of the Green Tea Polyphenol, EGCG, on Insulin Sensitivity Candidate: Huei Leng Helena Ng	2014
PhD	Microvascular Dysfunction and the Development of Muscle Insulin Resistance Candidate: Dino Premilovac	2012
PhD	Hemodynamic and Metabolic Actions of Adiponectin in Muscle Candidate: Carol Therese Bussey	2011
PhD	Role of the Microvasculature in the Development of Muscle Insulin Resistance Candidate: Philippe St-Pierre	2010
Masters	Vascular and Metabolic Actions of Insulin and AMPK Activation in Muscle Candidate: Eloise Alice Bradley	2009
PhD	Enhancing Blood Flow and Glucose Uptake in Insulin-Resistant Skeletal Muscle Candidate: Amanda Joan Genders	2009
PhD	Exercise and Insulin: Muscle Haemodynamics and Metabolism Candidate: Renee Ross	2007
PhD	Glucose Uptake in Skeletal Muscle Candidate: Cathryn Mary Kolka	2006
PhD	Insulin-Mediated Capillary Recruitment: Regulatory and Anatomical Aspects Candidate: Lei Zhang	2005
PhD	Hemodynamic and metabolic changes in muscle in relation to insulin action Candidate: Hema Mahajan	2005
PhD	Novel Technologies and Measurement of Microvascular Blood Flow in Muscle Candidate: Andrew Douglas Hastings Clark	2005
PhD	Interactions between contraction, insulin and thiazolidinediones in skeletal muscle; a focus on capillary recruitment Candidate: Catherine Mary Wheatley	2004