Profiles

Coral Warr

UTAS Home Professor Coral Warr

Coral Warr

Head of Biomedicine

Room 414C, Medical Science 1, Hobart CBD Campuses

+61 3 6226 7779 (phone)

Coral.Warr@utas.edu.au

Professor Coral Warr is a molecular geneticist and cell biologist fascinated by how signals from the environment determine how an animal develops and behaves. Cells in our nose can detect thousands of different chemicals. How does an animal know what these chemicals represent and what the response should be? Other cells in our brain detect signals that determine how fast we grow and to what size. Understanding how this works is critical because dysregulation of cell signalling during growth underlies many of the major diseases that afflict society, including cancer and obesity.

Professor Warr researches these questions using the fruit fly Drosophila melanogaster. Drosophila is a wonderful organism to study because most cell signalling pathways are shared with humans, so researchers can make discoveries using flies, then translate them to human biology. Fundamental work using flies is much faster than in many other animals, and in flies there are many sophisticated genetic and molecular approaches available to study gene function.

‘I’m very much curiosity-driven. Making a new discovery is the most exciting aspect to my research,’ says Professor Warr, who has recently moved to UTAS as Head of Biomedicine in the School of Medicine. ‘But more people here are focused on human health and translational research,’ she says, ‘so there are opportunities to make my research more broadly applicable.’

Professor Warr describes her first encounter with fruit flies in her Honours year. ‘I was researching the visual system of the fly and became addicted to the speed with which we could manipulate the genome. We could introduce specific mutations and look at the effects very quickly. Flies could be used to understand human biology and to model human disease.

Later, during her postdoc at Yale, ‘I discovered a very important family of genes in the sensory neurons that insects use to detect odours in the environment,’ says Professor Warr. ‘Humans have similar neurons, but for insects the sense of smell is much more important because they use it to detect host plants, where they might feed, lay eggs or gather for mating.

‘Once these genes were found in the model flies, we could find the genes in other insects important to agriculture and medicine – for example, in insects that spread malaria by smelling us and biting us.

‘We used a very creative method to find the genes. Yale was an amazing place to work so this was a wonderful experience. The resulting paper opened up a massive new field of research.’

Professor Warr is now focused on neuropeptides used for signalling between cells in the nervous system to regulate animal growth. ‘These are highly conserved between flies and humans, so discoveries are easily translated to human biology.’

Interestingly, Professor Warr didn’t make a beeline for science after leaving school, despite it being her strong subject. ‘I went to a country high school in Gippsland where the priority was seen as getting a good job, and a Bachelor of Science didn’t fit with that. Later I realised science was what I was best at and what I loved.’ She enrolled in a BSc at Melbourne University, thinking she’d become a physicist. ‘I hadn’t studied biology at school. In first year uni I did so and fell in love with genetics. I love the problem-solving and logical aspects, and that it is continually advancing.’

UTAS offers a conducive environment for Professor Warr, being ‘very strong in neuroscience. In the School of Medicine and the Menzies Research Institute there are lots of people whom I can work with to translate my findings to humans.’ There are fantastic facilities for research and all share the research space. ‘Hobart exhibits a strong connection between the university and the community – a shared sense of ownership, which is different to where I come from in Melbourne. It’s like a college town in the US.’

Professor Warr’s olfaction research, currently focused on odorant receptors in an Australian blowfly that causes flystrike in sheep, may lead to environmentally friendly methods of pest control. ‘And I hope my work on neuropeptides and growth will lead to knowledge about how body size and obesity is regulated in humans, and to greater understanding of related disorders.’

Professor Warr is a molecular geneticist and cell biologist who studies how cells receive and respond to signals from the environment (such as in olfaction) or from each other (such as during development). Her group uses the fruit fly Drosophila melanogaster as a model organism due to the sophisticated genetic and molecular approaches available to study gene function and expression. Further details at: http://coralwarr.com/

Prof Warr completed her PhD at the University of Melbourne in 1997, then completed postdoctoral studies at Yale University in the USA. She established her own group at Monash University in 2001, and moved to UTAS as Head of Biomedicine in 2018.

Biography

Before joining the University of Tasmania, Prof Warr was an academic in the School of Biological Sciences at Monash University in Melbourne for 17 years. She also served as the Associate Dean Research for the Faculty of Science at Monash for 3 years. Like many fly researchers her passion for all things fly began during her PhD, which she completed at the University of Melbourne working on Drosophila phototransduction. She then undertook postdoctoral studies at Yale University where she was a first author on the studies that uncovered the gene families encoding receptors involved in olfaction and taste in Drosophila. She leads a research program in Drosophila neurogenetics, with a focus on how cells respond to signals from their environment to control growth and in the chemosensory system. Prof Warr is a strong advocate for genetics and for model organism research via roles as the President of the Genetics Society of AustralAsia, on the board of Science Technology Australia (the body that liaises between scientific societies and government), and on the international Fly Board. She has convened two Genetics Society of AustralAsia meetings, and in 2017 convened the inaugural Australian Model Organisms in Human Health meeting. She is also a passionate educator and over her career has taught genetics to Science and Biomedical Science students at all undergraduate levels. Her research students have gone onto successful careers in many areas, including in academia.

Career summary

Qualifications

  • Graduate Certificate in Higher Education, Monash University, Australia, 2004
  • PhD (Genetics), University of Melbourne, Australia, 1997
  • BSc (Hons Genetics),University of Melbourne, Australia, 1992

Memberships

Professional practice

  • Genetics Society of AustralAsia
  • Australian and New Zealand Society for Cell and Developmental Biology
  • Genetics Society of America

Administrative expertise

  • Head of Biomedicine, School of Medicine, University of Tasmania, 2018-present
  • Associate Dean of Research, Faculty of Science, Monash University, 2016-2018
  • Deputy Head, School of Biological Sciences, Monash University, 2010-2014

Teaching

Genetics, Cell Biology, Molecular Biology, Developmental Biology, Cellular neuroscience

Teaching expertise

Prof Warr is a highly committed educator who drives innovation and excellence both in her individual areas of responsibility and more broadly. She has taught undergraduate genetics at all levels of the curriculum, and has a long history of educational excellence, innovation, and leadership. She has taught and coordinated units in fundamental genetics, medical genetics, developmental genetics, and cell biology. She aims for students to leave university with an understanding of how genetics impinges on societal issues, of how scientific research works, and with strong critical-thinking and problem-solving abilities that increase their employability.

Teaching responsibility

Research Invitations

  • 2018 EMBO meeting on the Molecular and Developmental Biology of Drosophila, Kolymbari, Greece
  • 2017 Workshop on the Torso Signalling pathway, Imperial College London
  • Plenary speaker at Genetics Society of AustralAsia Conference, Dunedin NZ, 2017.
  • 2014 United States Drosophila meeting Ecdysone Workshop, San Diego.
  • 2013 International Society for Chemical Ecology meeting in Melbourne
  • Invited Seminars at Florey Institute (2017), Yale University (2015), University of California Riverside (2015), University of Queensland (2014), University of Melbourne (2013).

View more on Professor Coral Warr in WARP

Expertise

  • Neurogenetics
  • Cell biology of growth and embryo development
  • Genetic basis of disease
  • Molecular genetics of olfaction in insects
  • Insect neurobiology

Research Themes

Prof Warr’s research interests align with the University research theme of Better Health. She leads a research program in Drosophila cellular and developmental genetics, with a focus on how cells respond to signals from their environment. Her group has made seminal contributions to understanding cell signalling in three areas of biology: (1) sensory systems – by discovering the families of genes that encode the olfactory and taste receptors in insects and determining how they function; (2) embryo patterning – by solving a long standing puzzle of how signalling pathways are controlled in a spatially localised manner; (3) growth – by discovering novel mechanisms of controlling steroid hormone production.

Collaboration

Selected past and current collaborations:

  • Professor Tony Tiganis, Monash University: the regulation of cellular signalling by protein tyrosine phosphatases, led to the discovery of a previously undescribed role for an adaptor protein in insulin signalling (Wu et al., 2011) and important evidence for the role of phosphatase subcellular localisation in substrate selectivity (Buszard et al., 2013).
  • Professor James Whisstock (Monash University): the function of the Membrane Attack Complex/Perforin-like (MACPF) protein Torso-like in embryo patterning. Has led to some highly significant findings (Johnson et al., 2013; Henstridge et al., 2014: Johnson et al., 2015).
  • Dr Christen Mirth (Monash University): how neuropeptide signalling pathways regulate endocrine control of growth in insects (Henstridge et al., 2018).
  • Professor Philip Batterham and Dr Trent Perry (University of Melbourne) and Dr Anand Ray (University of Riverside, USA): the functional evolution of the insect odorant receptor proteins across fly species.

Current projects

See lab website.

Fields of Research

  • Neurogenetics (060410)
  • Developmental Genetics (incl. Sex Determination) (060403)
  • Cell Metabolism (060104)
  • Signal Transduction (060111)
  • Systems Physiology (111603)
  • Structural Biology (incl. Macromolecular Modelling) (060112)
  • Genetic Immunology (060406)
  • Enzymes (060107)
  • Genomics (060408)
  • Receptors and Membrane Biology (060110)
  • Cell Development, Proliferation and Death (060103)
  • Animal Physiology - Systems (060603)
  • Animal Physiological Ecology (060806)
  • Molecular Evolution (060409)

Research Objectives

  • Expanding Knowledge in the Biological Sciences (970106)
  • Health Related to Ageing (920502)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Cancer and Related Disorders (920102)
  • Diabetes (920104)
  • Nervous System and Disorders (920111)
  • Control of Animal Pests, Diseases and Exotic Species in Farmland, Arable Cropland and Permanent Cropland Environments (960403)
  • Inherited Diseases (incl. Gene Therapy) (920110)
  • Sheep - Wool (830311)
  • Sheep - Meat (830310)

Publications

Prof Warr’s work is routinely published in the highest quality journals, with eight senior author publications in the journals Nature Communications (x2), PNAS, PLOS Genetics, Molecular Biology & Evolution, and Genetics (x3) over the last three years.

Total publications

41

Journal Article

(40 outputs)
YearCitationAltmetrics
2019Cordero PRF, Grinter R, Hards K, Cryle MJ, Warr CG, et al., 'Two uptake hydrogenases differentially interact with the aerobic respiratory chain during mycobacterial growth and persistence', Journal of Biological Chemistry ISSN 1083-351X (2019) [Refereed Article]

DOI: 10.1074/jbc.RA119.011076 [eCite] [Details]

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2019Shaw K, Johnson TK, Anderson A, de Bruyne M, Warr CG, 'Molecular and functional evolution at the odorant receptor Or22 locus in Drosophila melanogaster', Molecular Biology and Evolution, 36, (5) pp. 919-929. ISSN 0737-4038 (2019) [Refereed Article]

DOI: 10.1093/molbev/msz018 [eCite] [Details]

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2019Taylor SE, Tuffery J, Bakopoulos D, Lequeux S, Warr CG, et al., 'The torso-like gene functions to maintain the structure of the vitelline membrane in Nasonia vitripennis, implying its co-option into Drosophila axis formation', Biology open, 8, (9) pp. 1-11. ISSN 2046-6390 (2019) [Refereed Article]

DOI: 10.1242/bio.046284 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2018Johns AR, Henstridge MA, Saligari MJ, Moore KA, Whisstock JC, et al., 'Genome-wide screen for new components of the Drosophila melanogaster Torso receptor tyrosine kinase pathway', G3: Genes, Genomes, Genetics, 8, (3) pp. 761-769. ISSN 2160-1836 (2018) [Refereed Article]

DOI: 10.1534/g3.117.300491 [eCite] [Details]

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2018Henstridge MA, Aulsebrook L, Koyama T, Johnson TK, Whisstock JC, et al., 'Torso-like is a component of the hemolymph and regulates the insulin signaling pathway in drosophila', Genetics, 208, (4) pp. 1523-1533. ISSN 0016-6731 (2018) [Refereed Article]

DOI: 10.1534/genetics.117.300601 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

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2018Warr CG, Shaw KH, Azim A, Piper MDW, Parsons LM, 'Using mouse and Drosophila models to investigate the mechanistic links between diet, obesity, type II diabetes, and cancer', International Journal of Molecular Sciences, 19, (12) Article 4110. ISSN 1661-6596 (2018) [Refereed Article]

DOI: 10.3390/ijms19124110 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

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2017Johnson TK, Henstridge MA, Warr C, 'MACPF/CDC proteins in development: insights from Drosophila torso-like', Seminars in Cell and Developmental Biology, 72 pp. 163-170. ISSN 1084-9521 (2017) [Refereed Article]

DOI: 10.1016/j.semcdb.2017.05.003 [eCite] [Details]

Citations: Scopus - 2Web of Science - 1

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2017Johnson TK, Moore KA, Whisstock JC, Warr CG, 'Maternal Torso-Like coordinates tissue folding during drosophila gastrulation', Genetics, 206, (3) pp. 1459-1468. ISSN 0016-6731 (2017) [Refereed Article]

DOI: 10.1534/genetics.117.200576 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

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2017Richards CD, Warr C, Burke R, 'A role for the Drosophila zinc transporter Zip88E in protecting against dietary zinc toxicity', PLoS ONE, 12, (7) Article e0181237. ISSN 1932-6203 (2017) [Refereed Article]

DOI: 10.1371/journal.pone.0181237 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

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2017Willoughby LF, Manent J, Allan K, Lee H, Portela M, et al., 'Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants', FEBS Journal, 284, (14) pp. 2231-2250. ISSN 1742-464X (2017) [Refereed Article]

DOI: 10.1111/febs.14118 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2016Mercer SW, La Fontaine S, Warr C, Burke R, 'Reduced glutathione biosynthesis in Drosophila melanogaster causes neuronal defects linked to copper deficiency', Journal of Neurochemistry, 137, (3) pp. 360-370. ISSN 0022-3042 (2016) [Refereed Article]

DOI: 10.1111/jnc.13567 [eCite] [Details]

Citations: Scopus - 8Web of Science - 7

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2016Forbes-Beadle L, Crossman T, Johnson TK, Burke R, Warr C, et al., 'Development of the cellular immune system of Drosophila requires the membrane attack complex/perforin-like protein Torso-like', Genetics, 204, (2) pp. 675-681. ISSN 0016-6731 (2016) [Refereed Article]

DOI: 10.1534/genetics.115.185462 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

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2015Johnson TK, Henstridge MA, Herr A, Moore KA, Whisstock JC, et al., 'Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini', Nature Communications, 6 ISSN 2041-1723 (2015) [Refereed Article]

DOI: 10.1038/ncomms9759 [eCite] [Details]

Citations: Scopus - 20Web of Science - 20

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2014Duncan EJ, Johnson TK, Whisstock JC, Warr CG, Dearden PK, 'Capturing embryonic development from metamorphosis: How did the terminal patterning signalling pathway of Drosophila evolve?', Current Opinion in Insect Science, 1 pp. 45-51. ISSN 2214-5745 (2014) [Refereed Article]

DOI: 10.1016/j.cois.2014.04.007 [eCite] [Details]

Citations: Scopus - 4Web of Science - 5

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2014Ellisdon AM, Zhang Q, Henstridge MA, Johnson TK, Warr CG, et al., 'High resolution structure of cleaved Serpin 42 da from Drosophila melanogaster', BMC Structural Biology, 14, (1) pp. 1-8. ISSN 1472-6807 (2014) [Refereed Article]

DOI: 10.1186/1472-6807-14-14 [eCite] [Details]

Citations: Scopus - 11Web of Science - 12

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2014Henstridge MA, Johnson TK, Warr CG, Whisstock JC, 'Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like', Nature Communications, 5 pp. 1-7. ISSN 2041-1723 (2014) [Refereed Article]

DOI: 10.1038/ncomms4419 [eCite] [Details]

Citations: Scopus - 18Web of Science - 17

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2014Hwang JEC, De Bruyne M, Warr CG, Burke R, 'Copper overload and deficiency both adversely affect the central nervous system of Drosophila', Metallomics, 6, (12) pp. 2223-2229. ISSN 1756-5901 (2014) [Refereed Article]

DOI: 10.1039/c4mt00140k [eCite] [Details]

Citations: Scopus - 10Web of Science - 10

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2014Liu Y-C, Pearce MW, Honda T, Johnson TK, Charlu S, et al., 'The Drosophila melanogaster Phospholipid Flippase dATP8B Is Required for Odorant Receptor Function', PLoS Genetics, 10, (3) pp. 1-9. ISSN 1553-7390 (2014) [Refereed Article]

DOI: 10.1371/journal.pgen.1004209 [eCite] [Details]

Citations: Scopus - 8Web of Science - 7

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2014Nowotny T, De Bruyne M, Berna AZ, Warr CG, Trowell SC, 'Drosophila olfactory receptors as classifiers for volatiles from disparate real world applications', Bioinspiration and Biomimetics, 9, (4) pp. 1-13. ISSN 1748-3182 (2014) [Refereed Article]

DOI: 10.1088/1748-3182/9/4/046007 [eCite] [Details]

Citations: Scopus - 7Web of Science - 10

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2014Wang J, Binks T, Warr C, Burke R, 'Vacuolar-type H+-ATPase subunits and the neurogenic protein big brain are required for optimal copper and zinc uptake', Metallomics, 6, (11) pp. 2100-2108. ISSN 1756-5901 (2014) [Refereed Article]

DOI: 10.1039/c4mt00196f [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

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2013Buszard BJ, Johnson TK, Meng T-C, Burke R, Warr CG, et al., 'The Nucleus- and Endoplasmic Reticulum-Targeted Forms of Protein Tyrosine Phosphatase 61F Regulate Drosophila Growth, Life Span, and Fecundity', Molecular and Cellular Biology, 33, (7) pp. 1345-1356. ISSN 1098-5549 (2013) [Refereed Article]

DOI: 10.1128/MCB.01411-12 [eCite] [Details]

Citations: Scopus - 10Web of Science - 11

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2013Johnson TK, Crossman T, Foote KA, Henstridge MA, Saligari MJ, et al., 'Torso-like functions independently of Torso to regulate Drosophila growth and developmental timing', Proceedings of the National Academy of Sciences of the United States of America, 110, (36) pp. 14688-14692. ISSN 1091-6490 (2013) [Refereed Article]

DOI: 10.1073/pnas.1309780110 [eCite] [Details]

Citations: Scopus - 33Web of Science - 34

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2013Lye JC, Richards CD, Dechen K, Warr CG, Burke R, 'In vivo zinc toxicity phenotypes provide a sensitized background that suggests zinc transport activities for most of the Drosophila Zip and ZnT genes', Journal of Biological Inorganic Chemistry, 18, (3) pp. 322-332. ISSN 0949-8257 (2013) [Refereed Article]

DOI: 10.1007/s00775-013-0976-6 [eCite] [Details]

Citations: Scopus - 15Web of Science - 15

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2013Rances E, Johnson TK, Popovici J, Iturbe-Ormaetxe I, Zakir T, et al., 'The toll and Imd pathways are not required for wolbachia-mediated dengue virus interference', Journal of Virology, 87, (21) pp. 11945-11949. ISSN 0022-538X (2013) [Refereed Article]

DOI: 10.1128/JVI.01522-13 [eCite] [Details]

Citations: Scopus - 44Web of Science - 47

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2012Lye JC, Richards CD, Dechen K, Paterson D, De Jonge MD, et al., 'Systematic functional characterization of putative zinc transport genes and identification of zinc toxicosis phenotypes in Drosophila melanogaster', Journal of Experimental Biology, 215, (18) pp. 3254-3265. ISSN 0022-0949 (2012) [Refereed Article]

DOI: 10.1242/jeb.069260 [eCite] [Details]

Citations: Scopus - 28Web of Science - 29

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2012Tunstall NE, Herr A, de Bruyne M, Warr CG, 'A screen for genes expressed in the olfactory organs of Drosophila melanogaster identifies genes involved in olfactory behaviour', PLoS One, 7, (4) Article e35641. ISSN 1932-6203 (2012) [Refereed Article]

DOI: 10.1371/journal.pone.0035641 [eCite] [Details]

Citations: Scopus - 10Web of Science - 10

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2011Wu C-L, Buszard B, Teng C-H, Chen W-L, Warr CG, et al., 'Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling', Biochemical Journal, 439, (1) pp. 151-159. ISSN 0264-6021 (2011) [Refereed Article]

DOI: 10.1042/BJ20110799 [eCite] [Details]

Citations: Scopus - 14Web of Science - 15

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2010Marshall B, Warr CG, de Bruyne M, 'Detection of volatile indicators of illicit substances by the olfactory receptors of Drosophila melanogaster', Chemical Senses, 35, (7) pp. 613-625. ISSN 0379-864X (2010) [Refereed Article]

DOI: 10.1093/chemse/bjq050 [eCite] [Details]

Citations: Scopus - 32Web of Science - 28

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2010de Bruyne M, Smart R, Zammit E, Warr CG, 'Functional and molecular evolution of olfactory neurons and receptors for aliphatic esters across the Drosophila genus', Journal of Comparative Physiology A, 196, (2) pp. 97-109. ISSN 0340-7594 (2010) [Refereed Article]

DOI: 10.1007/s00359-009-0496-6 [eCite] [Details]

Citations: Scopus - 30Web of Science - 29

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2009Anderson AR, Wanner KW, Trowell SC, Warr CG, Jaquin-Joly E, et al., 'Molecular basis of female-specific odorant responses in Bombyx mori', Insect Biochemistry and Molecular Biology, 39, (3) pp. 189-197. ISSN 0965-1748 (2009) [Refereed Article]

DOI: 10.1016/j.ibmb.2008.11.002 [eCite] [Details]

Citations: Scopus - 67Web of Science - 65

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2008Smart R, Kiely A, Beale M, Vargas E, Carraher C, et al., 'Drosophila odorant receptors are novel seven transmembrane domain proteins that can signal independently of heterotrimeric G proteins', Insect Biochemistry and Molecular Biology, 38, (8) pp. 770-780. ISSN 0965-1748 (2008) [Refereed Article]

DOI: 10.1016/j.ibmb.2008.05.002 [eCite] [Details]

Citations: Scopus - 185Web of Science - 178

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2007Kiely A, Authier A, Kralicek AV, Warr CG, Newcombe RD, 'Functional analysis of a Drosophila melanogaster olfactory receptor expressed in Sf9 cells', Journal of Neuroscience Methods, 159, (2) pp. 189-194. ISSN 0165-0270 (2007) [Refereed Article]

DOI: 10.1016/j.jneumeth.2006.07.005 [eCite] [Details]

Citations: Scopus - 49Web of Science - 46

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2006De Bruyne M, Warr CG, 'Molecular and cellular organization of insect chemosensory neurons', BioEssays, 28, (1) pp. 23-34. ISSN 0265-9247 (2006) [Refereed Article]

DOI: 10.1002/bies.20338 [eCite] [Details]

Citations: Scopus - 35Web of Science - 26

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2005Goldman AL, Van Der Goes Van Naters W, Lessing D, Warr CG, Carlson JR, 'Coexpression of two functional odor receptors in one neuron', Neuron, 45, (5) pp. 661-666. ISSN 0896-6273 (2005) [Refereed Article]

DOI: 10.1016/j.neuron.2005.01.025 [eCite] [Details]

Citations: Scopus - 171Web of Science - 166

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2003Robertson HM, Warr CG, Carlson JR, 'Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster', Proceedings of the National Academy of Sciences of the United States of America, 100, (24) pp. 14537-14542. ISSN 0027-8424 (2003) [Refereed Article]

DOI: 10.1073/pnas.2335847100 [eCite] [Details]

Citations: Web of Science - 448

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2001Warr C, Clyne P, De Bruyne M, Kim J, Carlson JR, 'Olfaction in Drosophila: Coding, genetics and e-genetics', Chemical Senses, 26, (2) pp. 201-206. ISSN 0379-864X (2001) [Refereed Article]

DOI: 10.1093/chemse/26.2.201 [eCite] [Details]

Citations: Web of Science - 14

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2000Clyne PJ, Warr CG, Carlson JR, 'Candidate taste receptors in Drosophila', Science, 287, (5459) pp. 1830-1834. ISSN 0036-8075 (2000) [Refereed Article]

DOI: 10.1126/science.287.5459.1830 [eCite] [Details]

Citations: Scopus - 390Web of Science - 367

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2000Kim J, Moriyama EN, Warr CG, Clyne PJ, Carlson JR, 'Identification of novel multi-transmembrane proteins from genomic databases using quasi-periodic structural properties', Bioinformatics, 16, (9) pp. 767-775. ISSN 1367-4803 (2000) [Refereed Article]

DOI: 10.1093/bioinformatics/16.9.767 [eCite] [Details]

Citations: Scopus - 58Web of Science - 50

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1999Clyne PJ, Warr CG, Freeman MR, Lessing D, Kim J, et al., 'A novel family of divergent seven-transmembrane proteins: Candidate odorant receptors in Drosophila', Neuron, 22, (2) pp. 327-338. ISSN 0896-6273 (1999) [Refereed Article]

DOI: 10.1016/S0896-6273(00)81093-4 [eCite] [Details]

Citations: Scopus - 735Web of Science - 706

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1996Warr CG, Kelly LE, 'Identification and characterization of two distinct calmodulin-binding sites in the Trpl ion-channel protein of Drosophila melanogaster', Biochemical Journal, 314, (2) pp. 497-503. ISSN 0264-6021 (1996) [Refereed Article]

DOI: 10.1042/bj3140497 [eCite] [Details]

Citations: Scopus - 79Web of Science - 72

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Chapter in Book

(1 outputs)
YearCitationAltmetrics
2012Tunstall NE, Warr CG, 'Chemical communication in insects: The peripheral odour coding system of drosophila melanogaster', Sensing in Nature, Sensing in Nature, C Lopez-Larrea (ed), United States, pp. 59-77. ISBN 978-1-4614-1703-3 (2012) [Research Book Chapter]

DOI: 10.1007/978-1-4614-1704-0_4 [eCite] [Details]

Citations: Scopus - 19Web of Science - 19

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Grants & Funding

Prof Warr has received many grants from the Australian Research Council, including a current grant which involves the identification and characterisation of novel neuropeptide receptors that control growth and body size. With her collaborators Dr Linda Parson and Dr Matt Piper at Monash University she also has a current National Health and Medical Research Fund grant for a project that examines links between nutrition sensing and growth.

In addition Prof Warr has regularly received grants for teaching innovation, for projects aimed at increasing inquiry-based learning, and also student employability.

Funding Summary

Number of grants

2

Total funding

$1,012,135

Projects

Deciphering the role of SIK3 in development and disease (2019 - 2022)$632,735
Description
As the world's aging population increases, accompanied by unsustainable health care costs, one of the grand challenges of our age is to understand therelationship between diet, metabolism and human health.To answer these questions animal models that allow precise manipulation of dietary input combined with the capacity to assess nutrient levels, activation ofmolecular networks and changes in pathology are needed. However, transgenic mouse models that manipulate nutrient status are in their infancy. The fruitflyDrosophila provides an excellent alternative, as the conservation of fundamental cell biology and nutrient sensing pathways between flies and humans meansthat studies in Drosophila can deliver pivotal breakthroughs in our understanding of nutrition and animal growth which are applicable to human health.We have identified the nutrient sensing kinase Salt Inducible Kinase 3 (SIK3) as a candidate molecular link between cell metabolism and growth pathways.SIK3 is well characterised as a regulator of cell metabolism, specifically glucose homeostasis, in response to nutrition.We recently discovered a new role for SIK3 as a critical regulator of animal growth in both Drosophila (CIA Parsons) and mammals (AI Daly). The SIK3gene thus provides a unique entry point for the dissection of the molecular mechanisms that coordinate cell metabolism, growth and diet. The key goal of thisproposal is to determine how SIK3 acts as a molecular link between diet, metabolism and growth signalling pathways.
Funding
National Health & Medical Research Council ($632,735)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Parsons L; Warr C; Piper M; Cagan R
Period
2019 - 2022
Grant Reference
1158335
A novel regulator of growth signalling in Drosophila (2016 - 2018)$379,400
Funding
Australian Research Council ($379,400)
Scheme
Grant-Discovery Projects
Administered By
University of Tasmania
Research Team
Warr C; Mirth C; Tiganis T
Period
2016 - 2018
Grant Reference
DP160102797

Research Supervision

Coral has supervised 8 PhD students to completion as main supervisor, and many more as Associate Supervisor. She has supervised over 30 honours students, of which 28 students obtained first class honours. She has supervised over 30 third year student research projects.

As she has recently joined University of Tasmania Coral is looking for honours and PhD students. Her projects suit students with a good grounding in genetics or molecular and cell biology.

Current

1

Current

DegreeTitleCommenced
PhDCharacterising the Role of Novel Neuropeptide Receptors in Growth in Drosophila Melanogaster2019