Profiles

Graeme Zosky

UTAS Home Associate Professor Graeme Zosky
Graeme Zosky

Graeme Zosky

Deputy Director, Menzies Institute for Medical Research
Professor of Physiology, School of Medicine

Room 414A (Level 4), MS1 Medical Sciences Precinct, Hobart CBD Campuses

+61 3 6226 6921 (phone)

Graeme.Zosky@utas.edu.au

Respiratory disease is the most common reason that young children are hospitalised.

But, according to Graeme Zosky, Deputy Director of the Menzies Institute for Medical Research, ‘without knowing more about lung physiology, we can’t improve the health of these children.’

Professor Zosky is a respiratory physiologist whose research looks at ways to better understand how our lungs function. He has collaborated with engineers on the design of new imaging techniques that can be applied to the lung. ‘Existing techniques produce static images. These new techniques track movement, allowing us to see what the lungs are doing as they expand and contract.’

These techniques allow Professor Zosky to study the connection between lung mechanics and health and to investigate the underlying molecular and cellular mechanisms that determine this relationship.

He partners with specialists at the Royal Hobart Hospital to look at how his findings can be applied to the clinical care of patients, for example, to reduce the risk of lung damage to patients receiving mechanical ventilation.

'The response of the lung to mechanical ventilation varies a lot from patient to patient,’ Professor Zosky says. ‘Ultimately, these studies may lead to personalised approaches based on the lung function of individual patients.'

Professor Zosky also investigates the factors during pregnancy and early infancy that make a person more or less susceptible to lung disease later in life. He uses data collected in cohort studies to identify critical factors. He then uses experimental models to work out how these risk factors have their effect.

This research has provided important evidence of the connection between lung disease and factors such as vitamin D deficiency, air pollution and maternal exposure to arsenic in drinking water (a significant problem in Southeast Asia and other parts of the world).

'It is clear that if you start behind with lung function, you don’t catch up and you are at an increased risk of a chronic lung disease later in life.'

These results have public health applications. Improved understanding of the range of risk factors, how important each one is in different regions, and who is susceptible, can lead to better strategies for protecting vulnerable people.

'I’d like to think that we can get to the stage where everyone has an equal start to life in terms of their respiratory health.'

This work has led Professor Zosky to look more broadly at environmental health, that is, how variations in exposure to pollutants and other environmental factors affect a range of health outcomes including rates of cardiometabolic diseases and diabetes.

Professor Zosky has found a number of advantages to doing his research in Tasmania.

'There is a lot of community buy-in to the research we do, and the strong links we have developed allow for really interesting collaborations, for example with public health authorities and the hospital.'

A/Prof Graeme Zosky is an Associate Professor of Physiology at the School of Medicine in the College of Health and Medicine. He runs an independently funded research program that aims to understand the origins and prevention of chronic lung disease in order to reduce the burden of disease in the community.

Biography

A/Prof Zosky joined the School of Medicine at the University of Tasmania in 2013. Prior to that, he spent 10 years as a full-time research scientist at the Telethon Kids Institute in Western Australia where he was a Faculty member and Head of a research group focussed on understanding the early life origins of chronic lung disease. He has a PhD in Zoology (UWA) and a Masters in Biostatistics (USyd).

A/Prof Zosky is an active researcher with an independently funded research program. He currently leads the Lung Growth and Environmental Health research group in the School of Medicine. His research maintains a focus on the early life origins of chronic lung disease but his interests have expanded to include studies on environmental health, the optimisation of ventilation strategies in critical care and the fundamentals of lung structure-function relationships.

Career summary

Qualifications

Degree

University

Country

Date of award

BSc (1st Class Hons)

University of Western Australia

Australia

1999

MBiostat

University of Sydney

Australia

2010

PhD

University of Western Australia

Australia

2003

Memberships

Professional practice

  • Member, Thoracic Society of Australia and New Zealand,
  • Member, American Thoracic Society
  • Member, European Respiratory Society
  • Member, Asia Pacific Society of Respirology

Teaching

Physiology, cardiovascular, respiratory, research skills

Teaching responsibility

Research Appointments

  • Editorial Board, Scientific Reports (2016-)
  • TSANZ Occupational and Environmental Lung Disease Special Interest Group (Deputy Convenor 2014-2016; Chair 2017-)
  • Member, National Health and Medical Research Council GRP (2014, 2016, 2017)
  • Member, Thoracic Society of Australia and New Zealand Research Committee (2015-)
  • Member, American Thoracic Society RSF Planning Committee (2013-2017)
  • Member, Australian Synchrotron IMBL Program Advisory Committee (2012-2014)

Research Invitations

  • Invited Speaker – Thoracic Society of Australia and New Zealand ASM (2017) – “Can we target the early life origins of COPD to slow progression?”
  • Plenary Speaker – Thoracic Society of Australia and New Zealand ASM (2015) – “Mechanisms of the respiratory effects of air pollution”
  • Invited Speaker – Flow-volume underworld (2015) – “Early life environmental exposures and lung growth”
  • Invited Speaker – Australian Health and Medical Research Society ASM (2014) – “Vitamin D and chronic lung disease”
  • Invited Speaker – Hunter Medical Research Institute Seminar Series (NSW) (2014) – “Shining a light on vitamin D and asthma”
  • Invited Speaker – Tasmanian Haematology Immunology and Neoplasia Group ASM (TAS) (2014): “Arsenic exposure via drinking water and chronic lung disease”
  • Western Australian Young Tall Poppy Science Award, Australian Institute of Policy and Science (2013)
  • Invited Speaker – Woolcock Institute Seminar Series (NSW) (2013): “Vitamin D deficiency, lung development and chronic lung disease”
  • Guest Speaker – Asthma Foundation (W.A.) Research Grant Awards (2013): “The importance of research: towards improved outcomes for asthmatics
  • Invited Speaker – COPD8 International Conference (UK) (2012): “Animal models of vitamin D deficiency”
  • Invited Speaker – Australian Physiological Society Conference (2011): “Alterations in lung structure can perpetuate inflammation leading to chronic lung disease”
  • Rising Star of W.A. Respiratory Science TSANZ (W.A.) Invited Speaker (2008): “In utero exposure to arsenic alters post-natal lung function”

View more on Professor Graeme Zosky in WARP

Expertise

  • The early life determinants of chronic lung disease
  • Respiratory environmental health
  • Respiratory physiology

Research Themes

Dr Zosky is a biomedical researcher based in the School of Medicine at the Medical Sciences Precinct in Hobart. His research is strongly aligned with the University's 'Better Health' research theme and primarily focusses on the early life origins of chronic lung disease. His research covers four broad areas within respiratory science including:

  1. The early life determinants of lung growth (e.g. vitamin D, arsenic, air pollution) with a focus on structure-function relationships in health and disease
  2. The environmental determinants of lung health
  3. The impact of environmental exposure on respiratory health in remote Aboriginal communities
  4. The design of novel techniques for the assessment of lung structure and function

Collaboration

A/Prof Zosky has a wide range of cross disciplinary collaborations including several national and international partnerships.

International: Prof Zoltan Hantos (Engineer, University of Szeged, Hungary), Assoc Prof Tim LeCras (Molecular Biologist, Cincinnati Children's Hospital, U.S.A.), Prof Paulo Pitrez (Paediatric Pulmonologist: University of Porto Alegre, Brazil).

National: CAR Centre for Air Quality Research and Evaluation (Prof Guy Marks, Prof Bin Jalulidin, Prof Shyamali Dharmage, Prof Michael Abramson), Dr Peter Noble (Physiologist, UWA), A/Prof Alexander Larcombe (Respiratory researcher, Telethon Kids Institute), Prof Alan James (Clinician, Sir Charles Gairdner Hospital), Prof Andreas Fouras (Engineer, Monash University), Prof Peter Henry (Pharmacologist, U.W.A), A/Prof Brian Oliver (Cell biologist, University of Technology Sydney), A/Prof David Parsons (CF researcher, S.A.), Dr Martin Donnelley (CF researcher, S.A.).

Local: Assoc Prof Peter Dargaville (Neonatologist), Dr Stephen Tristram (Microbiologist), Dr Fay Johnston (Epidemiologist), Dr Nuri Guven (Pharmacologist), A/Prof Lisa Foa (Neuroscientist), Prof Greg Woods (Immunologist), Dr Bruce Lyons (Immunologist).

Awards

  • Western Australian Young Tall Poppy Science Award, Australian Institute of Policy and Science (2013)
  • Best Occupational and Environmental Health Presentation TSANZ ASM (2009, 2013)
  • American Thoracic Society Ann Woolcock Award (2011)
  • Postdoctoral Leadership Award, Telethon Institute for Child Health Research (2011)
  • Maurice Blackburn Lawyers International Travel Award (2009)
  • Asia Pacific Society of Respirology Featured Speaker – American Thoracic Society Conference (2009)
  • Rising Star of W.A. Respiratory Science TSANZ (W.A.) (2008)
  • Pfizer Biostatistics Collaboration of Australia Award for Excellence (2007)
  • QANTAS Young Investigator Award (2004)
  • Aubrey Nicholl's Memorial Prize in Zoology, U.W.A (1999)
  • Harry Waring Memorial Prize in Zoology, U.W.A. (1998)

Current projects

  • The impact of mechanical ventilation on regional lung mechanics and inflammation in the setting of pre-existing lung injury
  • The effect of exposure to iron laden geogenic (earth-derived) particles on the lung
  • The effect of particulate exposure from different sources (landscape fires, biomass burning) on lung inflammation and immune development
  • The role of environmental exposures in contributing to the health disparity in Aboriginal people living in remote communities
  • The impact of maternal vitamin D deficiency on lung development and the susceptibility to chronic lung disease later in life

Fields of Research

  • Respiratory Diseases (110203)
  • Health and Community Services (111708)
  • Environmental and Occupational Health and Safety (111705)
  • Comparative Physiology (060604)
  • Endocrinology (110306)
  • Aboriginal and Torres Strait Islander Health (111701)
  • Ecosystem Function (050102)
  • Cardiology (incl. Cardiovascular Diseases) (110201)
  • Medical Bacteriology (110801)
  • Cancer Genetics (111203)
  • Foetal Development and Medicine (111401)
  • Neurology and Neuromuscular Diseases (110904)
  • Environmental Monitoring (050206)
  • Community Child Health (111704)
  • Animal Immunology (060804)
  • Central Nervous System (110903)
  • Health Economics (140208)
  • Medical Biotechnology (100499)
  • Paediatrics (111403)
  • Pharmacology and Pharmaceutical Sciences (111599)
  • Systems Physiology (111603)
  • Medical and Health Sciences (119999)
  • Animal Physiology - Biophysics (060601)
  • Chemical Oceanography (040502)
  • Epigenetics (incl. Genome Methylation and Epigenomics) (060404)
  • Isotope Geochemistry (040203)
  • Medical Biochemistry: Amino Acids and Metabolites (110101)
  • Motor Control (110603)
  • Autonomic Nervous System (110901)

Research Objectives

  • Respiratory System and Diseases (incl. Asthma) (920115)
  • Environmental Health (920405)
  • Aboriginal and Torres Strait Islander Health - Determinants of Health (920301)
  • Child Health (920501)
  • Expanding Knowledge in the Biological Sciences (970106)
  • Diabetes (920104)
  • Cardiovascular System and Diseases (920103)
  • Nervous System and Disorders (920111)
  • Infectious Diseases (920109)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Occupational Health (920505)
  • Health (929999)
  • Immune System and Allergy (920108)
  • Reproductive System and Disorders (920114)
  • Expanding Knowledge in Technology (970110)
  • Blood Disorders (920101)
  • Digestive System Disorders (920105)
  • Health Education and Promotion (920205)
  • Endocrine Organs and Diseases (excl. Diabetes) (920106)
  • Inherited Diseases (incl. Gene Therapy) (920110)
  • Expanding Knowledge in the Earth Sciences (970104)
  • Physical and Chemical Conditions of Water in Marine Environments (961104)
  • Mental Health (920410)
  • Clinical Health (Organs, Diseases and Abnormal Conditions) (920199)
  • Nutrition (920411)
  • Urban and Industrial Air Quality (960106)
  • Urogenital System and Disorders (920119)

Publications

A/Prof Zosky’s major contributions to the field include the design of novel techniques for assessing lung mechanics in animal models which have been implemented in laboratories across the world. The application of these techniques has been instrumental in our understanding of the fundamental properties of lung tissue and the success of A/Prof Zosky’s research program.

Using these techniques, A/Prof Zosky has made a significant contribution to the field of respiratory environmental health and the impact of early life exposures on lung development and the susceptibility to chronic lung disease later in life. The impact of these contributions are highlighted by his invitations to speak at international conferences (COPD8, UK, 2012) and deliver plenary lectures (TSANZ ASM, 2015).

A/Prof Zosky’s work has been editorialised by eminent researchers in the field (Prof Scott Weiss, Prof Charles G. Irvin) and has resulted in regular media interviews (ABC National Radio, Nature).

Total publications

157

Highlighted publications

(8 outputs)
YearTypeCitationAltmetrics
2013Journal ArticleRamsey KA, Bosco A, McKenna KL, Carter KW, Elliot JG, et al., 'In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice', Environmental Health Perspectives, 121, (2) pp. 244-50. ISSN 0091-6765 (2013) [Refereed Article]

DOI: 10.1289/ehp.1205590 [eCite] [Details]

Citations: Scopus - 23Web of Science - 20

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2013Journal ArticleRamsey KA, Foong RE, Sly PD, Larcombe AN, Zosky GR, 'Early life arsenic exposure and acute and long-term responses to influenza A infection in mice', Environmental Health Perspectives, 121, (10) pp. 1187-93. ISSN 0091-6765 (2013) [Refereed Article]

DOI: 10.1289/ehp.1306748 [eCite] [Details]

Citations: Scopus - 31Web of Science - 26

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2011Journal ArticleCannizzaro V, Hantos Z, Sly PD, Zosky GR, 'Linking lung function and inflammatory responses in ventilator-induced lung injury', American Journal of Physiology: Lung Cellular and Molecular Physiology, 300, (1) pp. L112-L120. ISSN 1040-0605 (2011) [Refereed Article]

DOI: 10.1152/ajplung.00158.2010 [eCite] [Details]

Citations: Scopus - 21Web of Science - 21

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2011Journal ArticleZosky GR, Berry LJ, Elliott JG, James AL, Gorman S, et al., 'Vitamin D deficiency causes deficits in lung function and alters lung structure', American Journal of Respiratory and Critical Care Medicine, 183, (10) pp. 1336-1343. ISSN 1073-449X (2011) [Refereed Article]

DOI: 10.1164/rccm.201010-1596OC [eCite] [Details]

Citations: Scopus - 208Web of Science - 196

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2009Journal ArticleZosky GR, Cannizzaro V, Hantos Z, Sly PD, 'Protective mechanical ventilation does not exacerbate lung function impairment or lung inflammation following influenza A infection', Journal of Applied Physiology, 107, (5) pp. 1472-8. ISSN 8750-7587 (2009) [Refereed Article]

DOI: 10.1152/japplphysiol.00393.2009. [eCite] [Details]

Citations: Scopus - 15Web of Science - 14

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2008Journal ArticleZosky GR, Janosi TZ, Adamicza A, Bozanich EM, Cannizzaro V, et al., 'The bimodal quasi-static and dynamic elastance of the murine lung', Journal of Applied Physiology, 105, (2) pp. 685-92. ISSN 8750-7587 (2008) [Refereed Article]

DOI: 10.1152/japplphysiol.90328.2008 [eCite] [Details]

Citations: Scopus - 28Web of Science - 27

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2008Journal ArticleZosky GR, Larcombe AN, White OJ, Burchell JT, Janosi TZ, et al., 'Ovalbumin-sensitized mice are good models for airway hyperresponsiveness but not acute physiological responses to allergen inhalation', Clinical and Experimental Allergy, 38, (5) pp. 829-38. ISSN 0954-7894 (2008) [Refereed Article]

DOI: 10.1111/j.1365-2222.2007.02884.x [eCite] [Details]

Citations: Scopus - 52Web of Science - 46

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2006Journal ArticleStrickland DH, Stumbles PA, Zosky GR, Subrata LS, Thomas JA, et al., 'Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells', The Journal of Experimental Medicine, 203, (12) pp. 2649-60. ISSN 0022-1007 (2006) [Refereed Article]

DOI: 10.1084/jem.20060155 [eCite] [Details]

Citations: Scopus - 159Web of Science - 140

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Journal Article

(97 outputs)
YearCitationAltmetrics
2019Flies EJ, Mavoa S, Zosky GR, Mantzioris E, Williams C, et al., 'Urban-associated diseases: candidate diseases, environmental risk factors, and a path forward', Environment International pp. 1-47. ISSN 0160-4120 (In Press) [Refereed Article]

[eCite] [Details]

Co-authors: Flies EJ; Eri R; Brook BW; Buettel JC

2019Shao J, Wheeler AJ, Zosky GR, Johnston FH, 'Long-term impacts of prenatal and infant exposure to fine particulate matter on wheezing and asthma: A systematic review and meta-analysis', Environmental Epidemiology, 3, (2) pp. 1-7. ISSN 2474-7882 (2019) [Refereed Article]

DOI: 10.1097/EE9.0000000000000042 [eCite] [Details]

Co-authors: Wheeler AJ; Johnston FH

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2019Shao J, Zosky GR, Wheeler AJ, Dharmage S, Dalton M, et al., 'Exposure to air pollution during the first 1000 days of life and subsequent health service and medication usage in children', Environmental Pollution pp. 1-8. ISSN 0269-7491 (2019) [Refereed Article]

DOI: 10.1016/j.envpol.2019.113340 [eCite] [Details]

Co-authors: Wheeler AJ; Dalton M; Williamson GJ; O'Sullivan T; Chappell K; Johnston FH

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2019Shepherd CCJ, Clifford HD, Mitrou F, Melody SM, Bennett EJ, et al., 'The contribution of geogenic particulate matter to lung disease in indigenous children', International Journal of Environmental Research and Public Health, 16, (15) Article 2636. ISSN 1661-7827 (2019) [Refereed Article]

DOI: 10.3390/ijerph16152636 [eCite] [Details]

Co-authors: Melody SM; Bennett EJ; Johnston FH

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2019Thaver S, Bennett EJ, Foa L, Richards SM, Lyons AB, et al., 'Pregnancy protects against the pro-inflammatory respiratory responses induced by particulate matter exposure', Chemosphere, 225 pp. 796-802. ISSN 0045-6535 (2019) [Refereed Article]

DOI: 10.1016/j.chemosphere.2019.03.088 [eCite] [Details]

Co-authors: Thaver S; Bennett EJ; Foa L; Richards SM; Lyons AB

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2019Wang D, Chai X-q, Magnussen CG, Zosky GR, Shu S-h, et al., 'Renin-angiotensin-system, a potential pharmacological candidate, in acute respiratory distress syndrome during mechanical ventilation', Pulmonary Pharmacology and Therapeutics, 58 Article 101833. ISSN 1094-5539 (2019) [Refereed Article]

DOI: 10.1016/j.pupt.2019.101833 [eCite] [Details]

Co-authors: Magnussen CG

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2019Williams LJ, Zosky GR, 'The inflammatory effect of iron oxide and silica particles on lung epithelial cells', Lung, 197, (2) pp. 199-207. ISSN 0341-2040 (2019) [Refereed Article]

DOI: 10.1007/s00408-019-00200-z [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

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2019Wilson KM, Beggs SA, Zosky GR, Bereznicki LR, Bereznicki BJ, 'Parental knowledge, beliefs and management of childhood fever in Australia: A nationwide survey', Journal of Clinical Pharmacy and Therapeutics pp. 1-7. ISSN 0269-4727 (2019) [Refereed Article]

DOI: 10.1111/jcpt.13000 [eCite] [Details]

Co-authors: Wilson KM; Bereznicki LR; Bereznicki BJ

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2019Shao J, Zosky GR, Hall GL, Wheeler AJ, Dharmage S, et al., 'Early life exposure to coal mine fire smoke emissions and altered lung function in young children', Respirology pp. 1-8. ISSN 1323-7799 (2019) [Refereed Article]

DOI: 10.1111/resp.13617 [eCite] [Details]

Citations: Scopus - 2

Co-authors: Wheeler AJ; Melody S; Dalton M; O'Sullivan T; Williamson GJ; Chappell K; Johnston FH

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2018Rajendra KC, Zosky GR, Shukla SD, O'Toole RF, 'A cost-effective technique for generating preservable biomass smoke extract and measuring its effect on cell receptor expression in human bronchial epithelial cells', Biology Methods and Protocols, 3, (1) pp. 1-9. ISSN 2396-8923 (2018) [Refereed Article]

DOI: 10.1093/biomethods/bpy010 [eCite] [Details]

Co-authors: O'Toole RF

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2018Buckley AG, Looi K, Iosifidis T, Ling KM, Sutanto EN, et al., 'Visualisation of multiple tight junctional complexes in human airway epithelial cells', Biological Procedures Online, 20, (1) Article 3. ISSN 1480-9222 (2018) [Refereed Article]

DOI: 10.1186/s12575-018-0070-0 [eCite] [Details]

Citations: Scopus - 3Web of Science - 4

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2018Foneca AM, Zosky GR, Bozanich EM, Sutanto EN, Kicic A, et al., 'Accumulation mode particles and LPS exposure induce TLR-4 dependent and independent inflammatory responses in the lung', Respiratory Research, 19, (1) Article 15. ISSN 1465-9921 (2018) [Refereed Article]

DOI: 10.1186/s12931-017-0701-z [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

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2018Looi K, Buckley AG, Rigby PJ, Garratt LW, Iosifidis T, et al., 'Effects of human rhinovirus on epithelial barrier integrity and function in children with asthma', Clinical and Experimental Allergy, 48, (5) pp. 513-524. ISSN 0954-7894 (2018) [Refereed Article]

DOI: 10.1111/cea.13097 [eCite] [Details]

Citations: Scopus - 10Web of Science - 9

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2018Pickering J, Teo TH, Thornton RB, Kirkham LA, Zosky GR, et al., 'Bacillus licheniformis in geogenic dust induces inflammation in respiratory epithelium', Environmental Research, 164 pp. 248-254. ISSN 0013-9351 (2018) [Refereed Article]

DOI: 10.1016/j.envres.2018.02.025 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2018Preissner M, Murrie RP, Pinar I, Werdiger F, Carnibella RP, et al., 'High resolution propagation-based imaging system for in vivo dynamic computed tomography of lungs in small animals', Physics in Medicine and Biology, 63, (8) Article 08NT03. ISSN 0031-9155 (2018) [Refereed Article]

DOI: 10.1088/1361-6560/aab8d2 [eCite] [Details]

Citations: Scopus - 6Web of Science - 7

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2018Evans MA, Kim HA, Ling YH, Uong S, Vinh A, et al., 'Vitamin D3 supplementation reduces subsequent brain injury and inflammation associated with ischemic stroke', Neuromolecular Medicine, 20, (1) pp. 147-159. ISSN 1535-1084 (2018) [Refereed Article]

DOI: 10.1007/s12017-018-8484-z [eCite] [Details]

Citations: Scopus - 6Web of Science - 8

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2018Shao J, Wheeler AJ, Chen L, Strandberg B, Hinwood A, et al., 'The pro-inflammatory effects of particulate matter on epithelial cells are associated with elemental composition', Chemosphere, 202 pp. 530-537. ISSN 0045-6535 (2018) [Refereed Article]

DOI: 10.1016/j.chemosphere.2018.03.052 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Wheeler AJ; Chen L; Johnston FH

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2018Wang KCW, Le Cras TD, Larcombe AN, Zosky GR, Elliot JG, et al., 'Independent and combined effects of airway remodelling and allergy on airway responsiveness', Clinical Science, 132, (3) pp. 327-338. ISSN 0143-5221 (2018) [Refereed Article]

DOI: 10.1042/CS20171386 [eCite] [Details]

Citations: Scopus - 4Web of Science - 5

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2018Yen S, Preissner M, Bennett E, Dubsky S, Carnibella R, et al., 'The link between regional tidal stretch and lung injury during mechanical ventilation', American Journal of Respiratory Cell and Molecular Biology pp. 1-35. ISSN 1535-4989 (2018) [Refereed Article]

DOI: 10.1165/rcmb.2018-0143OC [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Yen S; Bennett E; O'Toole R; Roddam L; Dargaville PA

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2018Bereznicki BJ, Tucker MGA, Beggs SA, Zosky GR, Bereznicki LRE, 'Emergency department presentations of febrile children to an Australian public hospital', Journal of Paediatrics and Child Health, 54, (12) pp. 1308-1313. ISSN 1034-4810 (2018) [Refereed Article]

DOI: 10.1111/jpc.14071 [eCite] [Details]

Citations: Scopus - 1Web of Science - 2

Co-authors: Bereznicki BJ; Bereznicki LRE

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2018Chen L, Bennett E, Wheeler AJ, Lyons AB, Woods GM, et al., 'Maternal exposure to particulate matter alters early post-natal lung function and immune cell development', Environmental Research, 164 pp. 625-635. ISSN 0013-9351 (2018) [Refereed Article]

DOI: 10.1016/j.envres.2018.03.029 [eCite] [Details]

Citations: Scopus - 2Web of Science - 1

Co-authors: Chen L; Bennett E; Wheeler AJ; Lyons AB; Woods GM; Johnston F

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2017Chen L, Zosky GR, 'Lung development', Photochemical & Photobiological Sciences, 16, (3) pp. 339-346. ISSN 1474-9092 (2017) [Refereed Article]

DOI: 10.1039/C6PP00278A [eCite] [Details]

Citations: Web of Science - 1

Co-authors: Chen L

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2017Dong TTT, Hinwood AL, Callan AC, Zosky G, Stock WD, 'In vitro assessment of the toxicity of bushfire emissions: A review', Science of The Total Environment, 603-604 pp. 268-278. ISSN 0048-9697 (2017) [Refereed Article]

DOI: 10.1016/j.scitotenv.2017.06.062 [eCite] [Details]

Citations: Scopus - 4Web of Science - 3

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2017Dubsky S, Zosky GR, Perks K, Samarage CR, Henon Y, et al., 'Assessment of airway response distribution and paradoxical airway dilation in mice during methacholine challenge', Journal of Applied Physiology, 122, (3) pp. 503-510. ISSN 8750-7587 (2017) [Refereed Article]

DOI: 10.1152/japplphysiol.00476.2016 [eCite] [Details]

Citations: Scopus - 11Web of Science - 10

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2017Evans MA, Kim HA, De Silva TM, Arumugam TV, Clarkson AN, et al., 'Diet-induced vitamin D deficiency has no effect on acute post-stroke outcomes in young male mice', Journal of Cerebral Blood Flow and Metabolism ISSN 0271-678X (2017) [Refereed Article]

DOI: 10.1177/0271678X17719208 [eCite] [Details]

Citations: Scopus - 3Web of Science - 2

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2017Giblin R, Bennet E, Zosky GR, Dwyer RM, 'The Impact of Sex and 25(OH)D Deficiency on Metabolic Function in Mice', Nutrients, 9, (9) pp. 1-14. ISSN 2072-6643 (2017) [Refereed Article]

DOI: 10.3390/nu9090985 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Bennet E; Dwyer RM

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2017Kim EH, Preissner M, Carnibella R, Samarage CR, Bennet E, et al., 'Novel Analysis of 4DCT Imaging Quantifies Progressive Increases in Anatomic Dead Space During Mechanical Ventilation in Mice', Journal of Applied Physiology, 123, (3) pp. 578-584. ISSN 8750-7587 (2017) [Refereed Article]

DOI: 10.1152/japplphysiol.00903.2016 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Bennet E

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2017Chen L, Eapen MS, Zosky GR, 'Vitamin D both facilitates and attenuates the cellular response to lipopolysaccharide', Scientific Reports, 7 Article 45172. ISSN 2045-2322 (2017) [Refereed Article]

DOI: 10.1038/srep45172 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Chen L; Eapen MS

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2017Wang KCW, Astell CJ, Wijesinghe P, Larcombe AN, Pinniger GJ, et al., 'Optical coherence tomographybased contactindentation for diaphragm mechanics in a mouse model of transforming growth factor alpha induced lung disease', Scientific Reports, 7 Article 1517. ISSN 2045-2322 (2017) [Refereed Article]

DOI: 10.1038/s41598-017-01431-x [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

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2017Zosky GR, O'Shea JE, 'Cardiac autonomic innervation of the western pygmy possum (Cercatetus concinnus) and golden bandicoot (Isoodon auratus)', Journal of Comparative Physiology Part B: Biochemical, Systemic, and Environmental Physiology, 187, (1) pp. 203-211. ISSN 0174-1578 (2017) [Refereed Article]

DOI: 10.1007/s00360-016-1021-1 [eCite] [Details]

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2017Nunez NK, Bennett E, Chen L, Pitrez PM, Zosky GR, 'The independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific', Scientific Reports, 7 Article 15198. ISSN 2045-2322 (2017) [Refereed Article]

DOI: 10.1038/s41598-017-15517-z [eCite] [Details]

Co-authors: Nunez NK; Bennett E; Chen L

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2016Chen L, Wilson R, Bennett E, Zosky GR, 'Identification of vitamin D sensitive pathways during lung development', Respiratory Research, 17 pp. 1-11. ISSN 1465-993X (2016) [Refereed Article]

DOI: 10.1186/s12931-016-0362-3 [eCite] [Details]

Citations: Scopus - 15Web of Science - 14

Co-authors: Chen L; Wilson R; Bennett E

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2016Foong RE, Bosco A, Troy NM, Gorman S, Hart PH, et al., 'Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease', American Journal of Physiology, 311, (3) pp. 653-663. ISSN 1040-0605 (2016) [Refereed Article]

DOI: 10.1152/ajplung.00026.2016 [eCite] [Details]

Citations: Scopus - 7Web of Science - 6

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2016Looi K, Troy NM, Garratt LW, Iosifidis T, Bosco A, et al., 'Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability', Experimental Lung Research, 42, (7) pp. 380-395. ISSN 0190-2148 (2016) [Refereed Article]

DOI: 10.1080/01902148.2016.1235237 [eCite] [Details]

Citations: Scopus - 6Web of Science - 4

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2016Melody SM, Bennett E, Clifford HD, Johnston FH, Shepherd CCJ, et al., 'A cross-sectional survey of environmental health in remote Aboriginal communities in Western Australia', International Journal of Environmental Health Research, 26, (5-6) pp. 525-535. ISSN 1369-1619 (2016) [Refereed Article]

DOI: 10.1080/09603123.2016.1194384 [eCite] [Details]

Citations: Scopus - 7Web of Science - 7

Co-authors: Melody SM; Bennett E; Johnston FH

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2016Stahr CS, Samarage CR, Donnelley M, Farrow N, Morgan KS, et al., 'Quantification of heterogeneity in lung disease with image-based pulmonary function testing', Scientific Reports, 6 Article 29438. ISSN 2045-2322 (2016) [Refereed Article]

DOI: 10.1038/srep29438 [eCite] [Details]

Citations: Scopus - 12Web of Science - 14

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2016Thurgood J, Dubsky S, Uesugi K, Curtis M, Samarage CR, et al., 'Imaging lung tissue oscillations using high-speed X-ray velocimetry', Journal of Synchrotron Radiation, 23, (Pt 1) pp. 324-30. ISSN 0909-0495 (2016) [Refereed Article]

DOI: 10.1107/S1600577515021700 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

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2016Yates DH, Gibson PG, Hoy R, Zosky G, Miles S, et al., 'Down Under in the Coal Mines', American Journal of Respiratory and Critical Care Medicine, 194, (6) pp. 772-773. ISSN 1073-449X (2016) [Letter or Note in Journal]

DOI: 10.1164/rccm.201603-0615LE [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2016Fear VS, Lai SP, Zosky GR, Perks KL, Gorman S, et al., 'A pathogenic role for the integrin CD103 in experimental allergic airways disease', Physiological Reports, 4, (21) Article e13021. ISSN 2051-817X (2016) [Refereed Article]

DOI: 10.14814/phy2.13021 [eCite] [Details]

Citations: Scopus - 4

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2016Zosky GR, Hoy RF, Silverstone EJ, Brims FJ, Miles S, et al., 'Coal workers' pneumoconiosis: an Australian perspective', Medical Journal of Australia, 204, (11) pp. 414-418e2. ISSN 0025-729X (2016) [Refereed Article]

DOI: 10.5694/mja16.00357 [eCite] [Details]

Citations: Scopus - 13

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2015Clifford H, Pearson G, Franklin P, Walker R, Zosky G, 'Environmental health challenges in remote Aboriginal Australian communities: clean air, clean water and safe housing', Australian Indigenous Health Bulletin, 15, (2) pp. 1-13. ISSN 1445-7253 (2015) [Refereed Article]

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2015Clifford HD, Perks KL, Zosky GR, 'Geogenic PM10 exposure exacerbates responses to influenza infection', Science of the Total Environment, 533 pp. 275-282. ISSN 0048-9697 (2015) [Refereed Article]

DOI: 10.1016/j.scitotenv.2015.07.001 [eCite] [Details]

Citations: Scopus - 11Web of Science - 11

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2015Foong RE, Bosco A, Jones AC, Gout A, Gorman S, et al., 'The Effects of In Utero Vitamin D Deficiency on Airway Smooth Muscle Mass and Lung Function', American Journal of Respiratory Cell and Molecular Biology, 53, (5) pp. 664-675. ISSN 1535-4989 (2015) [Refereed Article]

DOI: 10.1165/rcmb.2014-0356OC [eCite] [Details]

Citations: Scopus - 27Web of Science - 22

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2015Hart PH, Lucas RM, Walsh JP, Zosky GR, Whitehouse AJO, et al., 'Vitamin D in fetal development: findings from a birth cohort study', Pediatrics, 135, (1) pp. e167-e173. ISSN 0031-4005 (2015) [Refereed Article]

DOI: 10.1542/peds.2014-1860 [eCite] [Details]

Citations: Scopus - 49Web of Science - 50

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2015Hawes JE, Tesic D, Whitehouse AJ, Zosky GR, Smith JT, et al., 'Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse', Behavioural Brain Research: An International Journal, 286 pp. 192-200. ISSN 0166-4328 (2015) [Refereed Article]

DOI: 10.1016/j.bbr.2015.03.008 [eCite] [Details]

Citations: Scopus - 36Web of Science - 36

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2015Tesic D, Hawes JE, Zosky GR, Wyrwoll CS, 'Vitamin D deficiency in BALB/c mouse pregnancy increases placental transfer of glucocorticoids', Endocrinology, 156, (10) pp. 1-8. ISSN 0013-7227 (2015) [Refereed Article]

DOI: 10.1210/en.2015-1377 [eCite] [Details]

Citations: Scopus - 19Web of Science - 17

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2014Atkins NA, Kunde DA, Zosky G, Tristram SG, 'Genotypically defined β-lactamase-negative ampicillin-resistant isolates of non-typable Haemophilus influenzae are associated with increased invasion of bronchial epithelial cells in vitro', Journal of Medical Microbiology, 63, (Pt 10) pp. 1400-3. ISSN 0022-2615 (2014) [Refereed Article]

DOI: 10.1099/jmm.0.077966-0 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Atkins NA; Kunde DA; Tristram SG

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2014Chen L, Perks KL, Stick SM, Kicic A, Larcombe AN, et al., 'House dust mite induced lung inflammation does not alter circulating vitamin D levels', PLoS One, 9, (11) Article e112589. ISSN 1932-6203 (2014) [Refereed Article]

DOI: 10.1371/journal.pone.0112589 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Chen L

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2014Foong RE, Shaw NC, Berry LJ, Hart PH, Gorman S, et al., 'Vitamin D deficiency causes airway hyperresponsiveness, increases airway smooth muscle mass, and reduces TGF-b expression in the lungs of female BALB/c mice', Physiological Reports, 2, (3) Article e00276. ISSN 2051-817X (2014) [Refereed Article]

DOI: 10.1002/phy2.276 [eCite] [Details]

Citations: Scopus - 26

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2014Phan JA, Kicic A, Berry LJ, Fernandes LB, Zosky GR, et al., 'Rhinovirus exacerbates house-dust-mite induced lung disease in adult mice', PLoS One, 9, (3) Article e92163. ISSN 1932-6203 (2014) [Refereed Article]

DOI: 10.1371/journal.pone.0092163 [eCite] [Details]

Citations: Scopus - 19Web of Science - 19

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2014Strickland DH, Fear V, Shenton S, Wikstrom ME, Zosky G, et al., 'Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following Influenza A Virus infection', PLoS One, 9, (11) Article e111520. ISSN 1932-6203 (2014) [Refereed Article]

DOI: 10.1371/journal.pone.0111520 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

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2014Zosky GR, Boylen CE, Wong RS, Smirk MN, Gutierrez L, et al., 'Variability and consistency in lung inflammatory responses to particles with a geogenic origin', Respirology, 19, (1) pp. 58-66. ISSN 1323-7799 (2014) [Refereed Article]

DOI: 10.1111/resp.12150 [eCite] [Details]

Citations: Scopus - 19Web of Science - 19

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2014Zosky GR, Hart PH, Whitehouse AJO, Hall GL, 'Reply: Seasonality and total 25-hydroxyviatmin D levels as sources of potential misclassification of vitamin D deficiency', Annals of the American Thoracic Society, 11, (8) pp. 1337-1338. ISSN 2325-6621 (2014) [Letter or Note in Journal]

DOI: 10.1513/AnnalsATS.201407-331LE [eCite] [Details]

Citations: Scopus - 1

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2014Zosky GR, Hart PH, Whitehouse AJO, Kusel MM, Ang W, et al., 'Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age', Annals of the American Thoracic Society, 11, (4) pp. 571-577. ISSN 2325-6621 (2014) [Refereed Article]

DOI: 10.1513/AnnalsATS.201312-423OC [eCite] [Details]

Citations: Scopus - 64

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2014Zosky GR, Iosifidis T, Perks K, Ditcham WGF, Devadason SG, et al., 'The concentration of iron in real-world geogenic PM10 is associated with increased inflammation and deficits in lung function in mice', PLoS One, 9, (2) Article e90609. ISSN 1932-6203 (2014) [Refereed Article]

DOI: 10.1371/journal.pone.0090609 [eCite] [Details]

Citations: Scopus - 15Web of Science - 12

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2013Foong RE, Zosky GR, 'Vitamin D deficiency and the lung: disease initiator or disease modifier?', Nutrients, 5, (8) pp. 2880-900. ISSN 2072-6643 (2013) [Refereed Article]

DOI: 10.3390/nu5082880 [eCite] [Details]

Citations: Scopus - 26Web of Science - 30

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2013Gorman S, Weeden CE, Tan DHW, Scott NM, Hart J, et al., 'Reversible control by vitamin D of granulocytes and bacteria in the lungs of mice: an ovalbumin-induced model of allergic airway disease', PLoS One, 8, (6) Article e67823. ISSN 1932-6203 (2013) [Refereed Article]

DOI: 10.1371/journal.pone.0067823 [eCite] [Details]

Citations: Scopus - 28Web of Science - 26

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2013Larcombe AN, Foong RE, Boylen CE, Zosky GR, 'Acute diesel exhaust particle exposure increases viral titre and inflammation associated with existing influenza infection, but does not exacerbate deficits in lung function', Influenza and Other Respiratory Viruses, 7, (5) pp. 701-709. ISSN 1750-2640 (2013) [Refereed Article]

DOI: 10.1111/irv.12012 [eCite] [Details]

Citations: Scopus - 8Web of Science - 6

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2013Larcombe AN, Zosky GR, Thamrin C, Bozanich EM, Hantos Z, et al., 'Factors influencing the assessment of lung function in mice with influenza-induced lung disease', Influenza and Other Respiratory Viruses, 7, (6) pp. 889-894. ISSN 1750-2640 (2013) [Refereed Article]

DOI: 10.1111/irv.12034 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

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2013Ramsey KA, Bosco A, McKenna KL, Carter KW, Elliot JG, et al., 'In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice', Environmental Health Perspectives, 121, (2) pp. 244-50. ISSN 0091-6765 (2013) [Refereed Article]

DOI: 10.1289/ehp.1205590 [eCite] [Details]

Citations: Scopus - 23Web of Science - 20

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2013Ramsey KA, Foong RE, Sly PD, Larcombe AN, Zosky GR, 'Early life arsenic exposure and acute and long-term responses to influenza A infection in mice', Environmental Health Perspectives, 121, (10) pp. 1187-93. ISSN 0091-6765 (2013) [Refereed Article]

DOI: 10.1289/ehp.1306748 [eCite] [Details]

Citations: Scopus - 31Web of Science - 26

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2013Ramsey KA, Foong RE, Zosky GR, 'Emerging Early Life Environmental Exposures and Lung Development', Journal of Environmental Immunology and Toxicology, 2, (1) pp. 14-23. ISSN 2225-1219 (2013) [Refereed Article]

DOI: 10.7178/jeit.18 [eCite] [Details]

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2013Ramsey KA, Larcombe AN, Sly PD, Zosky GR, 'In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice', BMC Pharmacology and Toxicology, 14, (1) Article 13. ISSN 2050-6511 (2013) [Refereed Article]

DOI: 10.1186/2050-6511-14-13 [eCite] [Details]

Citations: Scopus - 23Web of Science - 19

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2013Larcombe AN, Foong RE, Berry LJ, Zosky GR, Sly PD, 'In utero cigarette smoke exposure impairs somatic and lung growth in BALB/c mice', The European Respiratory Journal, 38, (4) pp. 932-938. ISSN 0903-1936 (2013) [Refereed Article]

DOI: 10.1183/09031936.00156910. [eCite] [Details]

Citations: Scopus - 19Web of Science - 19

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2012Cunningham PE, Elliot CE, Lenzo JC, Jarnicki AG, Larcombe AN, et al., 'Sensitizing and Th2 adjuvant activity of cysteine protease allergens', International Archives of Allergy and Immunology, 158, (4) pp. 347-358. ISSN 1018-2438 (2012) [Refereed Article]

DOI: 10.1159/000334280 [eCite] [Details]

Citations: Scopus - 22Web of Science - 23

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2012Wong RS, Larcombe AN, Fernandes LB, Zosky GR, Noble PB, 'The mechanism of deep inspiration-induced bronchoprotection: evidence from a mouse model', The European Respiratory Journal, 40, (4) pp. 982-989. ISSN 0903-1936 (2012) [Refereed Article]

DOI: 10.1183/09031936.00204311 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

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2011Boylen CE, Sly PD, Zosky GR, Larcombe AN, 'Physiological and inflammatory responses in an anthropomorphically relevant model of acute diesel exhaust particle exposure are sex and dose-dependent', Inhalation Toxicology, 23, (14) pp. 906-917. ISSN 0895-8378 (2011) [Refereed Article]

DOI: 10.3109/08958378.2011.625454. [eCite] [Details]

Citations: Scopus - 12Web of Science - 11

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2011Cannizzaro V, Hantos Z, Sly PD, Zosky GR, 'Linking lung function and inflammatory responses in ventilator-induced lung injury', American Journal of Physiology: Lung Cellular and Molecular Physiology, 300, (1) pp. L112-L120. ISSN 1040-0605 (2011) [Refereed Article]

DOI: 10.1152/ajplung.00158.2010 [eCite] [Details]

Citations: Scopus - 21Web of Science - 21

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2011Larcombe AN, Foong RE, Bozanich EM, Berry LJ, Gualano RC, et al., 'Sexual dimorphism in lung function responses to acute influenza A infection', Influenza and Other Respiratory Viruses, 5, (5) pp. 334-342. ISSN 1750-2640 (2011) [Refereed Article]

DOI: 10.1111/j.1750-2659.2011.00236.x [eCite] [Details]

Citations: Scopus - 39Web of Science - 36

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2011Zosky GR, 'Emerging issues in the Pacific Basin', Reviews on Environmental Health, 26, (1) pp. 39-44. ISSN 0048-7554 (2011) [Refereed Article]

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2011Zosky GR, Berry LJ, Elliott JG, James AL, Gorman S, et al., 'Vitamin D deficiency causes deficits in lung function and alters lung structure', American Journal of Respiratory and Critical Care Medicine, 183, (10) pp. 1336-1343. ISSN 1073-449X (2011) [Refereed Article]

DOI: 10.1164/rccm.201010-1596OC [eCite] [Details]

Citations: Scopus - 208Web of Science - 196

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2010Foong RE, Sly PD, Larcombe AN, Zosky GR, 'No role for neutrophil elastase in influenza-induced cellular recruitment, cytokine production or airway hyperresponsiveness in mice', Respiration Physiology and Neurobiology, 173, (2) pp. 164-70. ISSN 1569-9048 (2010) [Refereed Article]

DOI: 10.1016/j.resp.2010.08.003. [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

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2010McGlade JP, Strickland DH, Lambert MJM, Gorman S, Thomas JA, et al., 'UV inhibits allergic airways disease in mice by reducing effector CD4 T cells', Clinical and Experimental Allergy, 40, (5) pp. 772-85. ISSN 0954-7894 (2010) [Refereed Article]

DOI: 10.1111/j.1365-2222.2010.03469.x [eCite] [Details]

Citations: Scopus - 19Web of Science - 16

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2009Cannizzaro V, Berry LJ, Nicholls PK, Zosky GR, Turner DJ, et al., 'Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice', Respiration Physiology and Neurobiology, 169, (3) pp. 243-51. ISSN 1569-9048 (2009) [Refereed Article]

DOI: 10.1016/j.resp.2009.09.012 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

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2009Cannizzaro V, Berry LJ, Zosky GR, Turner DJ, Hantos Z, et al., 'Impact of supplemental oxygen in mechanically ventilated adult and infant mice', Respiration Physiology and Neurobiology, 165, (1) pp. 61-6. ISSN 1569-9048 (2009) [Refereed Article]

DOI: 10.1016/j.resp.2008.10.006. [eCite] [Details]

Citations: Scopus - 7Web of Science - 8

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2009Zosky GR, Cannizzaro V, Hantos Z, Sly PD, 'Protective mechanical ventilation does not exacerbate lung function impairment or lung inflammation following influenza A infection', Journal of Applied Physiology, 107, (5) pp. 1472-8. ISSN 8750-7587 (2009) [Refereed Article]

DOI: 10.1152/japplphysiol.00393.2009. [eCite] [Details]

Citations: Scopus - 15Web of Science - 14

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2009Zosky GR, Larcombe AN, White OJ, Burchell JT, von Garnier C, et al., 'Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways', American Journal of Physiology: Lung Cellular and Molecular Physiology, 297, (2) pp. L373-9. ISSN 1040-0605 (2009) [Refereed Article]

DOI: 10.1152/ajplung.00053.2009 [eCite] [Details]

Citations: Scopus - 20Web of Science - 17

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2008Bozanich EM, Gualano R, Zosky GR, Larcombe AN, Turner DJ, et al., 'Acute Influenza A infection induces bronchial hyper-responsiveness in mice', Respiration Physiology and Neurobiology, 162, (3) pp. 190-6. ISSN 1569-9048 (2008) [Refereed Article]

DOI: 10.1016/j.resp.2008.06.011. [eCite] [Details]

Citations: Scopus - 14Web of Science - 14

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2008Larcombe AN, Zosky GR, Bozanich EM, Turner DJ, Hantos Z, et al., 'Absence of cholinergic airway tone in normal BALB/c mice', Respiration Physiology and Neurobiology, 161, (3) pp. 223-9. ISSN 1569-9048 (2008) [Refereed Article]

DOI: 10.1016/j.resp.2008.01.009 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

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2008Zosky GR, Janosi TZ, Adamicza A, Bozanich EM, Cannizzaro V, et al., 'The bimodal quasi-static and dynamic elastance of the murine lung', Journal of Applied Physiology, 105, (2) pp. 685-92. ISSN 8750-7587 (2008) [Refereed Article]

DOI: 10.1152/japplphysiol.90328.2008 [eCite] [Details]

Citations: Scopus - 28Web of Science - 27

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2008Zosky GR, Larcombe AN, White OJ, Burchell JT, Janosi TZ, et al., 'Ovalbumin-sensitized mice are good models for airway hyperresponsiveness but not acute physiological responses to allergen inhalation', Clinical and Experimental Allergy, 38, (5) pp. 829-38. ISSN 0954-7894 (2008) [Refereed Article]

DOI: 10.1111/j.1365-2222.2007.02884.x [eCite] [Details]

Citations: Scopus - 52Web of Science - 46

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2008Cannizzaro V, Zosky GR, Hantos Z, Turner DJ, Sly PD, 'High tidal volume ventilation in infant mice', Respiration Physiology and Neurobiology, 162, (1) pp. 93-9. ISSN 1569-9048 (2008) [Refereed Article]

DOI: 10.1016/j.resp.2008.04.010. [eCite] [Details]

Citations: Scopus - 12Web of Science - 12

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2007Collins RA, Gualano RC, Zosky GR, Chiappetta CL, Turner DJ, et al., 'Lack of long-term effects of respiratory syncytial virus infection on airway function in mice', Respiration Physiology and Neurobiology, 156, (3) pp. 345-52. ISSN 1569-9048 (2007) [Refereed Article]

DOI: 10.1016/j.resp.2006.11.009 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

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2007McGlade JP, Gorman S, Zosky GR, Larcombe AN, Sly PD, et al., 'Suppression of the asthmatic phenotype by ultraviolet B-induced, antigen-specific regulatory cells', Clinical and Experimental Allergy, 37, (9) pp. 1267-76. ISSN 0954-7894 (2007) [Refereed Article]

DOI: 10.1111/j.1365-2222.2007.02750.x [eCite] [Details]

Citations: Scopus - 53Web of Science - 44

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2007Zosky GR, Sly PD, 'Animal models of asthma', Clinical and Experimental Allergy, 37, (7) pp. 973-988. ISSN 0954-7894 (2007) [Refereed Article]

DOI: 10.1111/j.1365-2222.2007.02740.x [eCite] [Details]

Citations: Scopus - 189Web of Science - 175

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2007von Garnier C, Wikstrom ME, Zosky GR, Turner DJ, Sly PD, et al., 'Allergic airways disease develops after an increase in allergen capture and processing in the airway mucosa', Journal of Immunology, 179, (9) pp. 5748-59. ISSN 0022-1767 (2007) [Refereed Article]

DOI: 10.4049/jimmunol.179.9.5748 [eCite] [Details]

Citations: Scopus - 38Web of Science - 33

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2006Jahnsen FL, Strickland DH, Thomas JA, Tobagus IT, Napoli S, et al., 'Accelerated antigen sampling and transport by airway mucosal dendritic cells following inhalation of a bacterial stimulus', Journal of Immunology, 177, (9) pp. 5861-7. ISSN 0022-1767 (2006) [Refereed Article]

DOI: 10.4049/jimmunol.177.9.5861 [eCite] [Details]

Citations: Scopus - 132Web of Science - 118

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2006Janosi TZ, Adamicza A, Zosky GR, Asztalos T, Sly PD, et al., 'Plethysmographic estimation of thoracic gas volume in apneic mice', Journal of Applied Physiology, 101, (2) pp. 454-9. ISSN 8750-7587 (2006) [Refereed Article]

DOI: 10.1152/japplphysiol.00011.2006 [eCite] [Details]

Citations: Scopus - 39Web of Science - 38

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2006Kendall M, Mitchell TJ, Costigan G, Armitage M, Lenzo JC, et al., 'Downregulation of IgE antibody and allergic responses in the lung by epidermal biolistic microparticle delivery', The Journal of Allergy and Clinical Immunology, 117, (2) pp. 275-82. ISSN 0091-6749 (2006) [Refereed Article]

DOI: 10.1016/j.jaci.2005.09.049 [eCite] [Details]

Citations: Scopus - 12Web of Science - 11

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2006Strickland DH, Stumbles PA, Zosky GR, Subrata LS, Thomas JA, et al., 'Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells', The Journal of Experimental Medicine, 203, (12) pp. 2649-60. ISSN 0022-1007 (2006) [Refereed Article]

DOI: 10.1084/jem.20060155 [eCite] [Details]

Citations: Scopus - 159Web of Science - 140

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2006Zosky GR, Sly PD, Turner DJ, 'Mouse models of asthma: what physiological evidence are they based on?', Allergy and Clinical Immunology International, 18 pp. 76-79. ISSN 1097-1424 (2006) [Refereed Article]

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2005Collins RA, Gualano RC, Zosky GR, Atkins CL, Turner DJ, et al., 'Hyperresponsiveness to inhaled but not intravenous methacholine during acute respiratory syncytial virus infection in mice', Respiratory Research, 6 pp. 142. ISSN 1465-9921 (2005) [Refereed Article]

DOI: 10.1186/1465-9921-6-142 [eCite] [Details]

Citations: Scopus - 23Web of Science - 21

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2004Zosky GR, von Garnier C, Stumbles PA, Holt PG, Sly PD, et al., 'The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose', Respiratory Research, 5 pp. 15. ISSN 1465-9921 (2004) [Refereed Article]

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2003Zosky GR, Larcombe AN, 'The parasympathetic nervous system and its influence on heart rate in torpid western pygmy possums, Cercatetus concinnus (Marsupialia: Burramyidae)', Zoology: Analysis of Complex Systems, 106, (2) pp. 143-50. ISSN 0944-2006 (2003) [Refereed Article]

DOI: 10.1078/0944-2006-00108 [eCite] [Details]

Citations: Scopus - 10Web of Science - 9

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2003Zosky GR, O'Shea JE, 'The cardiac innervation of a marsupial heterotherm, the fat-tailed dunnart (Sminthopsis crassicaudata)', Journal of Comparative Physiology. B: Biochemical, Systemic, and Environmental Physiology, 173, (4) pp. 293-300. ISSN 0174-1578 (2003) [Refereed Article]

DOI: 10.1007/s00360-003-0335-y [eCite] [Details]

Citations: Scopus - 4Web of Science - 3

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2002Zosky GR, 'A method for measuring the ECG and ventilation rate in bats', Journal of the Royal Society of Western Australia, 84 pp. 119-120. (2002) [Refereed Article]

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2002Zosky GR, O'Shea JE, 'The parasympathetic nervous system: its role during torpor in the fat-tailed dunnart (Sminthopsis crassicaudata)', Journal of Comparative Physiology. B: Biochemical, Systemic, and Environmental Physiology, 172, (8) pp. 677-84. ISSN 0174-1578 (2002) [Refereed Article]

DOI: 10.1007/s00360-002-0295-7 [eCite] [Details]

Citations: Scopus - 15Web of Science - 14

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(1 outputs)
YearCitationAltmetrics
2015Zosky GR, 'Aging of the normal lung', Comparative Biology of the Normal Lung, Academic Press, RA Parent (ed), United Kingdom, pp. 185-204. ISBN 978-0-12-404577-4 (2015) [Research Book Chapter]

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Review

(1 outputs)
YearCitationAltmetrics
2017Williams LJ, Chen L, Zosky GR, 'The respiratory health effects of geogenic (earth derived) PM10', Inhalation Toxicology, 29, (8) pp. 342-355. ISSN 0895-8378 (2017) [Substantial Review]

DOI: 10.1080/08958378.2017.1367054 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Chen L

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Conference Publication

(58 outputs)
YearCitationAltmetrics
2017Chen L, Bennett E, Wheeler A, Johnston F, Zosky G, 'Effect Of In Utero Exposure To Ceiling Particles On Post-Natal Lung Function And Immune Cell Populations', C105. Disorders of respiratory physiology and sleep in children, pp. A6889-A6889. (2017) [Conference Extract]

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Co-authors: Chen L; Bennett E; Wheeler A; Johnston F

2017Chen L, Bennett E, Wheeler A, Johnston F, Zosky G, 'Effect Of In Utero Exposure To Ceiling Particles on the Early Post-Natal Immune Cell Populations', Respirology (2017) [Conference Extract]

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Co-authors: Chen L; Bennett E; Wheeler A; Johnston F

2017Williams LJ, Latham R, Dwyer RM, O'Toole RF, Tristram SG, et al., 'The Impacts of Iron Laden Particulate Matter on NTHi Growth', Australian Society for Microbiology Annual Scientific Meeting 2017, 2-5 July 2017, Hobart, Tasmania (2017) [Conference Extract]

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Co-authors: Latham R; Dwyer RM; O'Toole RF; Tristram SG

2017Zosky G, Mitrou F, Melody S, Bennett E, Johnston F, et al., 'Self-Reported Geogenic Dust Exposure Is Associated With Increased Severity Of Infectious Diseases In Aboriginal Children', Respirology, pp. 59, Vol 22. ISSN 1323-7799 (2017) [Conference Extract]

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Co-authors: Melody S; Bennett E; Johnston F

2017Chen L, Bennett E, Wheeler A, Johnston F, Zosky G, 'Effect of In Utero Exposure to Ceiling Particles on Post-Natal Lung Function and Immune Cell Populations', Respirology, pp. 60, Vol 22. (2017) [Conference Extract]

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Co-authors: Chen L; Bennett E; Wheeler A; Johnston F

2015Elliot J, Wang K, Le Cras T, Larcombe A, Zosky GR, et al., 'Transforming growth factor alpha increases extracellular matrix within a transgenic mouse model of airway disease', Respirology, 27 March - 1 April, 2015, Gold Coast, Australia, pp. 96. ISSN 1323-7799 (2015) [Conference Extract]

DOI: 10.1111/resp.12495 [eCite] [Details]

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2015Looi K, Buckley A, Rigby P, Garratt L, Iosifidis T, et al., 'Disassembly of epithelial tight junctions in well-differentiated air-liquid interface (ALI) cultures following human rhinovirus infection results in airway epithelial permeability changes', Respirology, 27 March - 1 April, 2015, Gold Coast, Australia, pp. 70. ISSN 1323-7799 (2015) [Conference Extract]

DOI: 10.1111/resp.12495 [eCite] [Details]

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2015Looi K, Buckley A, Rigby P, Garrett LW, Iosifidis T, et al., 'Intrinsic Differences Of Epithelial Tight Junctions In Asthmatic Airway Epithelium And Barrier Compromisation Following Human Rhinoviral Insult', American Journal of Respiratory and Critical Care Medicine, 15-20 May, 2015, Denver, Colorado ISSN 1073-449X (2015) [Conference Extract]

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2015Wang K, Le Cras T, Larcombe A, Zosky GR, James A, et al., 'Independent effects of airway smooth muscle remodelling and allergic inflammation on airway responsiveness', Respirology, 27 March - 1 April, 2015, Gold Coast, Australia, pp. 23. ISSN 1323-7799 (2015) [Conference Extract]

DOI: 10.1111/resp.12494 [eCite] [Details]

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2015Wang KC, Le Crass TD, Zosky GR, James A, Noble PB, 'Independent Effects Of Airway Smooth Muscle Remodelling And Allergic Inflammation On Airway Responsiveness', American Journal of Respiratory and Critical Care Medicine, 15-20 May, 2015, Denver, Colorado ISSN 1073-449X (2015) [Conference Extract]

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2015Chen L, Foong R, Bennett Ellen, Zosky GR, 'In utero vitamin D deficiency alters the expression of MMPs in foetal lung', Respirology, 27-29 March, 2015, Gold Coast, Australia, pp. 140. ISSN 1323-7799 (2015) [Conference Extract]

DOI: 10.1111/resp.12495 [eCite] [Details]

Co-authors: Chen L; Bennett Ellen

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2015Larcombe A, Janka M, Looi K, Rigby P, Knight D, et al., 'Influenza infection facilitates allergen-specific responses in pre-sensitized mice', Respirology, 27 March - 1 April, 2015, Gold Coast, Australia, pp. 98. ISSN 1323-7799 (2015) [Conference Extract]

DOI: 10.1111/resp.12495 [eCite] [Details]

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2014Fouras A, Dubsky S, Samarage C, Thurgood J, Henon Y, et al., 'Local Lung Function And Airway Size Response During Methacholine Challenge And Salbutamol Treatment Measured Using High-Resolution Dynamic CT And Functional Lung Imaging', American Journal of Respiratory and Critical Care Medicine, May 18, 2014, San Diego ISSN 1073-449X (2014) [Conference Extract]

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2014Wang K, Le Crast T, Larcombe A, Zosky GR, James A, et al., 'A Mouse Model of Asthma', Respirology, 4-9 April, 2014, Adelaide, Australia ISSN 1323-7799 (2014) [Conference Extract]

DOI: 10.1111/resp.12263_9 [eCite] [Details]

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2014Zosky GR, Hart P, Whitehouse A, Kusel M, Foong R, et al., 'Maternal vitamin D deficiency is associated with impaired lung function and asthma in children', Respirology, 4-9 April, 2014, Adelaide, Australia ISSN 1323-7799 (2014) [Conference Extract]

DOI: 10.1111/resp.12263_9 [eCite] [Details]

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2014Foong RE, Shaw NC, Hart PH, Gorman S, Zosky GR, 'Maternal Vitamin D Deficiency Does Not Cause Airway Hyperresponsiveness And Increased Airway Smooth Muscle In Young Mice', American Journal of Respiratory and Critical Care Medicine, May 21, 2014, San Diego ISSN 1073-449X (2014) [Conference Extract]

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2014Zosky GR, Ramsey KA, Carter KW, Bosco A, McKenna KL, et al., 'In utero arsenic exposure via drinking water alters genes related to lung growth and mucociliary function', Respirology, 2-6 April 2011, Perth, Australia, pp. 29. ISSN 1323-7799 (2014) [Conference Extract]

DOI: 10.1111/j.1440-1843.2011.01936.x [eCite] [Details]

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2014Zosky GR, Perks K, Clifford H, 'Exposure to iron laden geogenic dust exacerbates the response to influenza infection', Respirology, 4-9 April, 2014, Adelaide, Australia ISSN 1323-7799 (2014) [Conference Extract]

DOI: 10.1111/resp.12262_16 [eCite] [Details]

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2013Clifford HD, Perks K, Larcombe AN, Zosky GR, 'Exacerbation Of A Respiratory Viral Infection By Low Doses Of Geogenic Dust', American Journal of Respiratory and Critical Care Medicine, May 20, 2013, Philadelphia Pennsylvania ISSN 1073-449X (2013) [Conference Extract]

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2013Clifford HD, Perks K, Larcombe AN, Zosky GR, 'Exacerbation of influenza infection by low doses of geogenic dust', Respirology, 23-27 March, 2013, Darwin, Australia, pp. 21. ISSN 1323-7799 (2013) [Conference Extract]

DOI: 10.1111/resp.12045 [eCite] [Details]

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2013Foong R, Berry LJ, Gorman S, Hart PH, Zosky GR, 'Vitamin D deficiency protects against the effects of chronic house dust mite exposure', Respirology, 23-27 March, 2013, Darwin, Australia, pp. 41. ISSN 1323-7799 (2013) [Conference Extract]

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2013Foong RE, Berry JL, Hart PH, Gorman S, Zosky GR, 'Vitamin D Deficiency Has Protective Effects In A Mouse Model Of Chronic House Dust Mite Exposure', American Journal of Respiratory and Critical Care Medicine, May 20, 2013, Philadelphia, Pennsylvania ISSN 1073-449X (2013) [Conference Extract]

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2013Zosky GR, 'The importance of research: towards improved outcomes for asthmatics', Asthma Foundation of W.A. Research Awards Keynote Presentation (2013), 1-7 September, 2013, Perth, Australia (2013) [Keynote Presentation]

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2013Zosky GR, Wong RS, Smirk MN, Perks K, Iosifidis T, et al., 'Identifying The Key Drivers Of The Lung Response To Inhaled Geogenic Dusts', American Journal of Respiratory and Critical Care Medicine, May 22, 2013, Philadelphia Pennsylvania ISSN 1073-449X (2013) [Conference Extract]

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2013Zosky GR, Wong RS, Smirk MN, Perks K, Iosifidis T, et al., 'Identifying The Key Drivers Of The Lung Response To Inhaled Geogenic Dusts', Respirology, 23-27 March, 2013, Darwin, Australia, pp. 21. ISSN 1323-7799 (2013) [Conference Extract]

DOI: 10.1111/resp.12045 [eCite] [Details]

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2013Zosky GR, Wong RS, Smirk MN, Perks K, Iosifidis T, et al., 'Identifying The Key Drivers Of The Lung Response To Inhaled Geogenic Dusts', Respirology, 23-27 March, 2013, Darwin, Australia, pp. 21. ISSN 1323-7799 (2013) [Conference Extract]

DOI: 10.1111/resp.12045 [eCite] [Details]

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2012Foong RE, Gorman S, Hart PH, Zosky GR, 'Vitamin D Deficiency Alters Lung Function But Does Not Have An Effect On Airway Smooth Muscle Mass', American Journal of Respiratory and Critical Care Medicine, 18-23 May, 2012, San Francisco, California ISSN 1073-449X (2012) [Conference Extract]

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2012Foong RE, Gorman S, Hart PH, Zosky GR, 'Vitamin D deficiency causes deficits in lung function but does not alter airway smooth muscle mass', Respirology, 15-17 August, 2012, Queenstown, New Zealand, pp. 26. ISSN 1323-7799 (2012) [Conference Extract]

DOI: 10.1111/j.1440-1843.2012.02142.x [eCite] [Details]

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2012Ramsey KA, Foong RE, Sly P, Zosky GR, 'Arsenic Is A Developmental Toxicant To The Lung', American Journal of Respiratory and Critical Care Medicine, 18-23 May, 2012, San Francisco, California (2012) [Conference Extract]

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2012Ramsey KA, Sly PD, Larcombe AN, Zosky GR, 'Arsenic exposure via drinking water adversely affects lung health', Respirology, 15-17 August, 2012, Queenstown, New Zealand, pp. 25. ISSN 1323-7799 (2012) [Conference Extract]

DOI: 10.1111/j.1440-1843.2012.02142.x [eCite] [Details]

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2012Zosky GR, Boylen CE, Wong RS, Gutierrez L, Woodward RC, et al., 'Characterizing the respiratory inflammatory response to geogenic dusts', Respirology, 15-17 August, 2012, Queenstown, New Zealand, pp. 37. ISSN 1323-7799 (2012) [Conference Extract]

DOI: 10.1111/j.1440-1843.2012.02142.x [eCite] [Details]

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2011Foong RE, Boylen CE, Larcombe AN, Zosky GR, 'Acute diesel exhaust particle exposure increases viral titre associated with influenza but does not exacerbate inflammation or deficits in lung function', Respirology, 2-6 April 2011, Perth, Australia, pp. 43. ISSN 1323-7799 (2011) [Conference Extract]

DOI: 10.1111/j.1440-1843.2011.01937.x [eCite] [Details]

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2011Larcombe AN, Boylen CE, Sly PD, Zosky GR, 'Acute exposure to diesel exhaust particles elicits dose-dependent pulmonary inflammatory and impairment of lung function in naive BALB/C mice', Respirology, 2-6 April 2011, Perth, Australia, pp. 65. ISSN 1323-7799 (2011) [Conference Extract]

DOI: 10.1111/j.1440-1843.2011.01937.x [eCite] [Details]

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2011Ramsey KA, Larcombe AN, Sly PD, Zosky GR, 'Whole life arsenic exposure via drinking water results in impaired lung function and airway hyperresponsiveness', Respirology, 2-6 April 2011, Perth, pp. 25. ISSN 1323-7799 (2011) [Conference Extract]

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2011Wong PR, Larcombe AN, Fernandes LB, Zosky GR, Noble PB, 'Deep inspiration prior to bronchoconstrictor challenge has beneficial and detrimental effects on lung mechanics in mice', Respirology, 2-6 April 2011, Perth, Australia, pp. 43. ISSN 1323-7799 (2011) [Conference Extract]

DOI: 10.1111/j.1440-1843.2011.01937.x [eCite] [Details]

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2011Zosky GR, Berry LJ, Elliot JG, James AL, Gorman S, et al., 'Vitamin D deficiency causes deficits in lung function and alters lung structure', Respirology, 2-6 April 2011, Perth, pp. 25. ISSN 1323-7799 (2011) [Conference Extract]

DOI: 10.1111/j.1440-1843.2011.01936.x [eCite] [Details]

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2011Zosky GR, Ramsey KA, Berry LJ, Larcombe AN, Sly PD, et al., 'Stepwise Changes In Lung Function And Growth With Age In Mice', American Journal of Respiratory and Critical Care Medicine, 13-18 May, 2011, Denver, Colorado ISSN 1073-449X (2011) [Conference Extract]

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2011Larcombe AN, Foong RE, Boylen CE, Zosky GR, 'Acute Diesel Exhaust Particle Exposure Increases Viral Titre Associated With Influenza But Does Not Exacerbate Inflammation Or Deficits In Baseline Lung Function', American Journal of Respiratory and Critical Care Medicine, 13-18 May, 2011, Denver, Colorado ISSN 1073-449X (2011) [Conference Extract]

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2010Foong RE, Larcombe AN, Zosky GR, Sly PD, 'No role for neutrophil serine proteases in influenza-induced hyperresponsiveness', Respirology, 20-24 March 2010, Brisbane, Australia, pp. A49. ISSN 1323-7799 (2010) [Conference Extract]

DOI: 10.1111/j.1400-1843.2010.01736.x [eCite] [Details]

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2010Larcombe AN, Foong RE, Zosky GR, Sly PD, 'In utero cigarette smoke exposure results in impaired growth and impaired lung function in neonatal BALB/C mice', Respirology, 20-24 March 2010, Brisbane, Australia, pp. A73. ISSN 1323-7799 (2010) [Conference Extract]

DOI: 10.1111/j.1400-1843.2010.01736.x [eCite] [Details]

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2010Ramsey KA, Larcombe AN, Foong RE, Sly PD, Zosky GR, 'Early Life Exposure To Arsenic And Influenza Has Additive Effects On Lung Function Impairment', American Journal of Respiratory and Critical Care Medicine, 14-19 May, 2010, New Orleans, Louisiana ISSN 1073-449X (2010) [Conference Extract]

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2010Ramsey KA, Larcombe AN, Foong RE, Sly PD, Zosky GR, 'Early life exposure to arsenic and influenza has additive effects on lung impairment', Respirology, 20-24 March 2010, Brisbane, Australia, pp. A73. ISSN 1323-7799 (2010) [Conference Extract]

DOI: 10.1111/j.1400-1843.2010.01736.x [eCite] [Details]

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2010Boylen CE, Sly PD, Zosky GR, Larcombe AN, 'Dose but not sex determines inflammatory responses to acute diesel exhaust particle exposure in mice', Respirology, 20-24 March 2010, Brisbane, Australia, pp. A73. ISSN 1323-7799 (2010) [Conference Extract]

DOI: 10.1111/j.1400-1843.2010.01736.x [eCite] [Details]

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2009Bozanich EM, Larcombe AN, Turner DJ, Zosky GR, Sly PD, 'Neonatal antigen and viral exposure alters airway and parenchymal responsiveness in adult mice', Respirology, 28-31 March 2008, Melbourne, Australia, pp. A33. ISSN 1323-7799 (2009) [Conference Extract]

DOI: 10.1111/j.1400-1843.2009.01503.x [eCite] [Details]

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2009Foong R, Bozanich EM, Gaulano RC, Kicic A, Zosky GR, et al., 'Both sex and type of virus influence lung inflammatory responses in BALB/C mice', Respirology, March 2009, Darwin, Australia, pp. A33. ISSN 1323-7799 (2009) [Conference Extract]

DOI: 10.1111/j.1400-1843.2009.01503.x [eCite] [Details]

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2009Larcombe AN, Bozanich EM, Turner DJ, Zosky GR, Sly PD, 'Female mice exposed to influenza A have greater inflammation and lung responsiveness compared to male mice', Respirology, March 2009, Darwin, Australia, pp. A32. ISSN 1323-7799 (2009) [Conference Extract]

DOI: 10.1111/j.1400-1843.2009.01503.x [eCite] [Details]

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2009Larcombe AN, Bozanich EM, Zosky GR, Turner DJ, Sly PD, 'Impact of Age of Infection and Sex on the Physiological Consequences of Influenza A Infection', American Journal of Respiratory and Critical Care Medicine, 15-20 May, 2009, San Diego, United States ISSN 1073-449X (2009) [Conference Extract]

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2009Zosky GR, Larcombe AN, Bozanich EM, Foong R, Turner DJ, et al., 'In Utero Exposure to Arsenic Via Drinking Water Alters Post−Natal Lung Function', American Journal of Respiratory and Critical Care Medicine, 15-20 May, 2009, San Diego, United States ISSN 1073-449X (2009) [Conference Extract]

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2009Zosky GR, Larcombe AN, Bozanich EM, Foong R, Turner DJ, et al., 'In Utero Exposure to Arsenic Via Drinking Water Alters Post−Natal Lung Function', Respirology, March 2009, Darwin, Australia, pp. A32. ISSN 1323-7799 (2009) [Conference Extract]

DOI: 10.1111/j.1400-1843.2009.01503.x [eCite] [Details]

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2008Bozanich EM, Gualano R, Larcombe AN, Zosky GR, Sly PD, et al., 'Persistence of airway hyperresponsiveness in mice infected with influenza as infants', Respirology, 28-31 March 2008, Melbourne, Australia, pp. A26. ISSN 1323-7799 (2008) [Conference Extract]

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2008Larcombe AN, Zosky GR, Turner DJ, Hantos Z, Sly PD, 'Measuring severe lung disease in mice - a cautionary tale', Respirology, 28-31 March 2008, Melbourne, Australia, pp. A26. ISSN 1323-7799 (2008) [Conference Extract]

DOI: 10.1111/j.1440-1843.2008.01252.x [eCite] [Details]

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2008Turner D, Larcome A, Zosky GR, Bozanich E, Hantos Z, et al., 'Absence of airway tone in BALB/c mice', Respirology, 28-31 March 2008, Melbourne, Australia, pp. A26. ISSN 1323-7799 (2008) [Conference Extract]

DOI: 10.1111/j.1440-1843.2008.01252.x [eCite] [Details]

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2008Zosky GR, Larcombe AN, Burchell JT, Wikstrom ME, Stumbles PA, et al., 'Airway hyperresponsiveness in mouse models of asthma is associated with activated T cells in the airways', Respirology, 28-31 March 2008, Melbourne, Australia, pp. A15. ISSN 1323-7799 (2008) [Conference Extract]

DOI: 10.1111/j.1440-1843.2008.01251.x [eCite] [Details]

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2007Bozanich EM, Gualano R, Zosky GR, Sly PD, Turner DJ, 'Physiological and immunological responses to allergen in three strains of mouse', Respirology, 22-25 May 2007, Sydney, Australia, pp. A33. ISSN 1323-7799 (2007) [Conference Extract]

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2007Larcombe AN, Zosky GR, Burchell JT, Wikstrom ME, Turner DJ, et al., 'Physiological and immunological responses to allergen in three strains of mouse', Respirology, 22-25 May 2007, Sydney, Australia, pp. A31. ISSN 1323-7799 (2007) [Conference Extract]

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2006Zosky GR, Larcombe AN, White OJ, Hantos Z, Sly PD, et al., 'Are mice good physiological models of asthma', Respirology, 2006, TSANZ 2006 Annual Scientific Meeting, Canberra, pp. A26. ISSN 1323-7799 (2006) [Conference Extract]

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2005Zosky GR, Collins RA, Sly PD, Turner DJ, 'Tracheal smooth muscle responses in a murine model of respiratory syncytial virus', Respirology, 19 March 2005, Perth, Australia, pp. A92. ISSN 1323-7799 (2005) [Conference Extract]

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2004Zosky GR, Birchell J, Sly P, Turner D, 'Characterisation of allergen induced airway hyperresponsiveness (AHR) in a murine model of allergic sensitisation', Respirology, 23 March 2004, Sydney, pp. A28. ISSN 1323-7799 (2004) [Conference Extract]

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Grants & Funding

Funding Summary

Number of grants

25

Total funding

$7,880,647

Projects

Adequacy of Risk Modelling in the Assessment of Particulate Matter in Parenteral Product Formulations (2019)$20,394
Funding
CSL Behring AG ($20,394)
Scheme
Consultancy
Administered By
University of Tasmania
Research Team
Zosky GR
Year
2019
Artificial stone associated silicosis (2019 - 2020)$38,000
Description
We will collect dust from benchtop fabrication companies in Victoria and/or Tasmania. We will then compare the capacity of these particles to stimulate pro-fibrotic pathways in human lung cells with the response generate by conventional silica particles obtained from the National Institutes of Standards and Technology (U.S.). We will purchase standard human lung cells with known roles in silicosis (epithelial cells and fibroblasts) and expose them to the particles in a dish in the laboratory and measure their response to the particles using state of the art techniques by measuring cell stress and the genes and proteins they produce in response to the dust.These experiments will allow us to: 1) determine whether silica dust from artificial stone is indeed more potent than conventional silica dust and, therefore, poses a greater risk of silicosis in workers in this industry and, 2) identify the cell response so that we may, in the future, be able to identify novel therapies for workers who suffer from silica dust induced lung disease.
Funding
Gordon Legal ($38,000)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Zosky GR
Period
2019 - 2020
What is the economic impact of allergic respiratory disease in Tasmania? (2019)$10,000
Description
This project will provide the first economic assessment of the burden of allergic respiratory disease (allergic rhinitis and allergic asthma) in Tasmania. Together, allergic rhinitis and allergic asthma affect over 20% of the Tasmanian population, yet there has been no rigorousanalysis of the health and economic impacts. This project will cost the direct and indirect costs of these conditions across Tasmania. In doing so, we will provide a rigorous evidence base to build a case for allergic respiratory research, and directly inform government and non-government investment in interventions. Our research will be co-designed with expert input from government and non-government stakeholders (Asthma Australia) to ensure alignment with end-user needs.
Funding
University of Tasmania ($10,000)
Scheme
Grant-Research Enhancement Program
Administered By
University of Tasmania
Research Team
Johnston F; Palmer AJ; Jones PJ; Bereznicki BJ; Cooling NB; Zosky GR
Year
2019
The link between regional lung stretch and distal organ injury in response to mechanical ventilation (2019 - 2021)$732,607
Description
Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) have very high mortality rates (over 30%). Unfortunately, mechanical ventilation, a life-saving intervention contributes to this high mortality. Interestingly, very few of these critically ill patients die from a lack of oxygen with the vast majority dying from "non-lung" organ failure. In this study we will investigate the mechanisms linking mechanical ventilation with organ failure with a view to improving mortality.
Funding
National Health & Medical Research Council ($732,607)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Zosky GR; Morgan K; Dubsky S
Period
2019 - 2021
Grant Reference
1160774
Understanding why mechanical ventilation contributes to mortality in critically ill patients. (2019)$23,650
Description
We will be assess regional variation in gene expression in the pre-injured septic lung in response to mechanical ventilation. By assessing the association between gene expression data and our quantitative imaging data, we will gain insight into how the mechanical response of the lung impacts on the biological response, which contributes to the high mortality in these patients, and how this is altered by pre-existing inflammation. By using RNAseq we also hope to identify novel pathways involved in the response.
Funding
Royal Hobart Hospital Research Foundation ($23,650)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Zosky GR; Dargaville P
Year
2019
In utero exposure to bushfire smoke and post-natal health (2019)$17,171
Description
When a pregnant woman is exposed to combustion-derived particles, there is a significant risk to the long-term health of her child(ren). We do not currently understand why this is the case or particles from different sources carry different risks. This study aims to address this gap in knowledge using a mouse model.
Funding
University of Tasmania ($17,171)
Scheme
Grant-Research Enhancement Program
Administered By
University of Tasmania
Research Team
Zosky GR
Year
2019
The impact of iron oxide particles on respiratory health (2018)$2,000
Description
PM10 (particulate matter < 10μm in mean aerodynamic diameter) is linked to the prevalence and severity of bronchitis, asthma, respiratory infections and mortality (1, 3, 4). While PM is typically defined by size, the chemical characteristics of the particles are likely to have a significance influence on the biological response and health effects associated with the inhalation of PM10.Current national air quality guidelines for particulate pollution are based entirely on data from urban particles, which are primarily from combustion sources (8), with no appreciation for the unique physico-chemical characteristics of airborne particles in rural and remote communities which are almost entirely geogenic (earth derived) (9). The lack of data on the health effects of geogenic particles needs to be addressed given that approximately 2.6% of the Australian population, including a high proportion of the Aboriginal community, live in the rural and remote regions of Australia (10). While the prevailing dogma is that geogenic particles are inert (11), there is convincing evidence that this is not true. For example, community sampled geogenic particles i) induce an inflammatory response in the lung (12), ii) impair lung function (13) and iii) impair responses to viral infection (14). Interestingly, the magnitude of these deficits is positively associated with the concentration of iron in the particles (13). This observation is supported by epidemiological studies from regional towns showing associations between exposure to iron oxide particles and an increased prevalence and severity of respiratory infections (15, 16).
Funding
Centre for Air Quality and Health Research Evaluation ($2,000)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Zosky GR
Year
2018
Identification of novel biomarkers of pollution exposure in adults (2018 - 2019)$19,033
Description
We aim to identify associations between protein expression in the serum (by proteomics) and exposure to NO2 (estimated by land use regression modelling) or indoor air pollution (assessed by questionnaire) in the TAHS cohort in order to identify novel, robust biomarkers of exposure to air pollution.
Funding
Centre for Air Quality and Health Research Evaluation ($19,033)
Scheme
Grant-Seeding
Administered By
University of Tasmania
Research Team
Zosky GR; Dharmage SC; Bowatte G
Period
2018 - 2019
Preclinical Development of Neuropeptide Y for the Treatment of Motor Neuron Disease (2017 - 2020)$936,575
Description
Motor Neuron Disease (MND) is a rapidly progressing neurodegenerative disease. There are no cures and no effective treatments for MND, with people diagnosed having a median survival of only three years from symptom onset. Not knowing the cause of MND or how it progresses through the CNS have been immense barriers to the development of effective therapeutics. We have reached a critical time in MND research. Our research team has been dedicated to researching the mechanism of MND for the last ten years. We are now poised to transition my teams research efforts from determining the cause of this disease to using this knowledge to develop treatments. A critical pathway that our work and others have shown is key to MND is altered network excitability and subsequent excitotoxicity in the cortex. We have recent published and preliminary data that identifies that a critical potential point of intervention in this pathway is via the subclass of inhibitory cells that express neuropeptide Y (NPY). The overarching Aim for this Cure for MND Translational Research Grant is to now target this pathway to develop a treatment. By performing this world-first preclinical trial we will reveal further aspects of disease pathogenesis. Positive outcomes from these trials will identify a candidate compounds for progression to a human trial for the treatment of MND.
Funding
FightMND ($936,575)
Scheme
Grant-Translational Research Grant
Administered By
University of Tasmania
Research Team
Dickson TC; Blizzard C; Pebay A; Walker A; Blizzard CL; Rogers M; Hewitt A; Zosky GR
Period
2017 - 2020
Energy transitions, air pollution and health in Australia (2017 - 2021)$2,491,230
Description
Emissions from burning biomass (including fossil fuels) are major features of our environment and are the 4th leading global risk factor for premature death.As countries shift their patterns of energy use in response to global warming, new challenges are emerging. Understanding this is crucial to our ability tomaintain health and stability in uncertain times. This CRE will examine the health consequences of (1) fossil fuel combustion, (2) landscape fires and (3)alternatives to fossil fuels. We will build on the multi-disciplinary collaborative approaches developed in our current CRE (the Centre for Air quality andhealth Research and evaluation, CAR). These approaches include: a) improved assessments of exposure using sensors, satellites and advanced statistics; b)cohort studies with data linkage; c) detailed measures of physiological endpoints; d) toxicological investigations; and e) intervention studies.Our plan for research translation will be guided by published high quality research. We will maintain the close collaboration with policymakers that we haveestablished over the last 5 years in CAR. In addition, we will employ a Translation and Knowledge Broker. We will establish Project-Specific AdvisoryGroups for each research theme and enhance our current active engagement with diverse conventional and unconventional media outlets.We have a plan for the development of the careers of air pollution researchers in Australia by ensuring that fellows are actively engaged in a diverse range ofprojects and disciplines relevant to air pollution research.Our team of 10 CIs, 10 AIs and 5 post-doctoral fellows from 5 Australian states reflects the successful development of the collaborative air pollution researchcommunity in Australia, under the influence of CAR, over the last 5 years. New cross-disciplinary and cross-national connections have been formed and haveled to funded research projects. The current proposal extends those gains.
Funding
National Health & Medical Research Council ($2,491,230)
Scheme
Grant-Centre of Research Excellence
Administered By
University of New South Wales
Research Team
Marks G; Jalaludin B; Abramson M; Morawska L; Dharmage SC; Johnston F; Morgan GG; Heyworth J; Zosky GR; Guo Y
Period
2017 - 2021
Grant Reference
1116412
Anti-inflammatory efficacy of Marinovas Fucoidan & interactions with microbiota (2016)$100,000
Description
Industry interaction to develop Marinovas fucoidan extracts for gut health
Funding
Department of Industry, Innovation and Science ($50,000); Marinova Pty Ltd ($50,000)
Scheme
Contract Research
Administered By
University of Tasmania
Research Team
Guven N; Eri RD; Ahuja KDK; Ball MJ; Ambrose M; Roddam LF; Zosky GR
Year
2016
Supporting respiratory research (2016)$100,000
Description
This donation is intended to support the work of the Breathe Well NHMRC CRE, based in the School of Medicine. The Centres NHMRC funding concludes this year. In particular, the donation is to support the completion of PhD projects and fund strategic research involving collaboration between respiratory researchers in the Faculty. This will enable the researchers to seek further NHMRC funding.
Funding
Donation via University of Tasmania Foundation ($100,000)
Scheme
Donation - Individual
Administered By
University of Tasmania
Research Team
Canny B; Walters EH; Zosky GR; O'Toole RF; Ferguson SG; Peterson GM; Sohal SS
Year
2016
Investigating the burden of childhood fever on Tasmanian families and the Royal Hobart Hospitals Emergency Department. (2016)$9,599
Description
This project will describe the presentations to the Royal Hobart Hospital emergency department by children with fever, investigate the knowledge, beliefs and perceptions about childhood fever among parents and caregivers in Tasmania, and develop an educational package for parents and caregivers about childhood fever.
Funding
Royal Hobart Hospital Research Foundation ($9,599)
Scheme
Grant-Starter
Administered By
University of Tasmania
Research Team
Bereznicki BJ; Beggs S; Bereznicki LRE; Zosky GR
Year
2016
The UTAS Smoke Lab: A request for CAR to fund essential equipment for an Australian facility for inter-disciplinary air quality research (2016)$17,683
Description
CAR collaborators have been working with researchers across a range of disciplines and institutions to establish a facility at the University of Tasmania for controlled combustion experiments, particle generation, emissions characterisation and testing of appliances such as biomass stoves. Existing facilities in Australia have capability for some of these functions, however coordinated research is limited by a range of different academic and commercial institutions which are geographically dispersed. Access to these facilities for public health research in particular, is limited and often very expensive (e.g. the cost of appliance emissions testing)..
Funding
Centre for Air Quality and Health Research Evaluation ($17,683)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Johnston F; Wheeler A; Williamson G; Zosky GR; Hinwood A; Todd J; Rein G; Strandberg B; Cope M
Year
2016
Hazelwood coal mine fire emissions: Are there risks for infant brain development? (2016)$14,959
Funding
University of Tasmania ($14,959)
Scheme
Grant-Research Enhancement (REGS)
Administered By
University of Tasmania
Research Team
Wheeler A; Johnston F; Zosky GR; Foa LC
Year
2016
Iron laden particulate matter enhances bacterial growth in the lung (2016)$49,753
Description
People living in regional and remote communities in Australia are exposed to very high levels of particles that are high in ironcontent. Current wisdom suggests that these particles are less harmful than particles that people are exposed to in urban areas; we have evidence tothe contrary. In this study we will determine the health implications of inhaling high concentrations of iron laden particles. In particular we willexamine the impact of iron rich particles on the lung when it is infected with bacteria. This will help us to understand why people who live in areaswith high levels of iron rich particles are more likely to be hospitalised for lung conditions. This study will allow us to set appropriate air qualityguidelines and to identify communities that are most at risk from airborne particles.
Funding
Australian Respiratory Council ($49,753)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Zosky GR
Year
2016
Regional mechanisms of ventilator induced lung injury: insights from dynamic lung imaging (2015 - 2017)$603,878
Funding
National Health & Medical Research Council ($603,878)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Zosky GR; Fouras A; Dargaville PA
Period
2015 - 2017
Grant Reference
1077905
Finding the right ventilator settings in patients with respiratory failure (2015)$19,826
Description
Based on data from Tasmania and across Australia the mortality rates due to acute respiratory distress syndrome (ARDS) are high (28-day mortality rate = 34%) (1). Paradoxically, mechanical ventilation, which is a necessary lifesaving strategy in ARDS, is thought to contribute to this high mortality rate (2). In the late 1990s the seminal ARDSNet trial (3), which showed a 22% reduction in mortality by reducing tidal volume from 12 to 6 mL.kg-1, was considered a major breakthrough. However, mortality rates due to ARDS have since flatlined (4) and improvements in patient outcomes has stalled. We argue that this impasse has arisen due to reliance on indirect measures of lung ventilation (5) and our inability to dynamically image the lung at a high resolution.
Funding
Royal Hobart Hospital Research Foundation ($19,826)
Scheme
Grant-Clinical Research
Administered By
University of Tasmania
Research Team
Zosky GR; Dargaville P
Year
2015
The impact of iron oxide particles on lung health (2015)$20,000
Description
Research has shown that community sampled geogenic (earth-derived) particles less than 10 m in aero-dynamic diameter (PM10) have the capacity to induce a dose-dependent inflammatory response in the lung in mice. Subsequent studies have demonstrated that the magnitude of this inflammatory response, the subsequent long-term deficits in lung mechanics, and the exacerbation of the response to a viral infection is strongly associated with the concentration of iron (Fe) in the particles. This observation is in contrast to the prevailing dogma which suggests that silica (SiO2) is the most detrimental (to the lung) constituent of geogenic particles. In fact, data shows an inverse relationship between the silica content of the particles and both the magnitude of the inflammatory response and deficit in lung mechanics. The principle aim of this study is to determine whether iron oxide particles cause adverse impacts on the lung. Specifically it aims to determine: 1) if "pure" iron oxide particles (< 10 m) are sufficient to induce lung inflammation and cause deficits in lung structure and function in a dose dependent manner; 2) if the lung response to iron oxide particles is altered by the presence of silica.
Funding
Thoracic Society of Australia & New Zealand ($20,000)
Scheme
Grant-In-Aid
Administered By
University of Tasmania
Research Team
Zosky GR
Year
2015
Childhood lung disease (2014)$25,000
Funding
Centenary Rebekah Lodge IOOF Inc ($25,000)
Scheme
Donation - Individual
Administered By
University of Tasmania
Research Team
Zosky GR
Year
2014
Vitamin D, lung growth and chronic lung disease (2014 - 2015)$415,777
Description
Vitamin D has been implicated in the pathogenesis of obstructive lung diseases (asthma and COPD). Research has recently demonstrated that vitamin D deficiency alters lung structure resulting in significant deficits in lung function using a mouse model suggesting that the link between vitamin D deficiency and obstructive lung disease may be due to altered lung development. There is now evidence that one of the primary structural deficits associated with vitamin D deficiency is an increase in airway smooth muscle (ASM) mass. Data demonstrates that this increase in ASM occurs early in life and translates into increased responses to broncho-constricting agents which is consistent with observations in human populations. This project hypothesises that; 1) vitamin D deficiency results in increased airway smooth muscle; 2) the increase in airway smooth muscle is established in utero; 3) the increase in airway smooth muscle is the mechanism uniting the associations between vitamin D deficiency and both asthma and COPD; 4) low levels of vitamin D in utero will be associated with lower postnatal lung function and airway hyperresponsiveness in children. The project will use a physiologically relevant mouse model of vitamin D deficiency in conjunction with state of the art techniques for assessing lung structure, lung function and gene expression. It will complement these studies with an analysis of human data in order to correlate maternal vitamin D status with postnatal responses to methacholine. Together these studies will provide the evidence required to direct clinical trials and/or public health interventions to ameliorate the burden of vitamin D deficiency on chronic lung disease in the community. By using cutting edge technologies in in-vivo animal studies that are not possible in human populations combined with targeted analyses of human data based on our predictions the project will be able to generate the most accurate data possible while ensuring that our results are relevant to human disease.
Funding
National Health & Medical Research Council ($415,777)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Zosky GR; Henry P; Gorman S; Le Cras T
Period
2014 - 2015
Grant Reference
1042235
From the synchrotron to the clinic: translation of a novel functional imaging technology (2013 - 2015)$859,797
Funding
NHMRC ($859,797)
Scheme
Development Grant
Administered By
Monash University
Research Team
Fouras A; Siu K; Hooper S; Watkins D; Parsons D; Zosky GR; Jenkins B; Spanswick D
Period
2013 - 2015
Airway smooth muscle and asthma (2012 - 2014)$396,250
Funding
NHMRC ($396,250)
Scheme
Project Grant
Administered By
University of Western Australia
Research Team
Noble PB; Zosky GR; Larcombe AN; James A
Period
2012 - 2014
Does abnormal epithelial function facilitate aero-allergen sensitization (2012 - 2014)$510,000
Funding
NHMRC ($510,000)
Scheme
Project Grant
Administered By
University of Western Australia
Research Team
Stick S; Kicic A; Larcombe AN; Zosky GR; Rigby P; Knight D
Period
2012 - 2014
Early life arsenic exposure alters lung development and inflammatory responses to virus and cigarette smoke (2010 - 2012)$447,465
Funding
NHMRC ($447,465)
Scheme
Project Grant
Administered By
University of Western Australia
Research Team
Zosky GR; Hantos Z; Hinwood A; Carter K
Period
2010 - 2012

Research Supervision

Current

8

Completed

2

Current

DegreeTitleCommenced
PhDThe Regional Lung Response to Mechanical Ventilation2015
PhDExposure to Iron Laden Particulate Matter Impacts on Respiratory Health2016
PhDAssessing the Infant Health Exposure to Severe Air Pollution2016
PhDDevelopment of Enhanced Drugs Against the Causative Agents of Tuberculosis and Bacterial Pneumonia2016
MastersSleep Pattern and Physiological Markers of Stress in Graduate Paramedics2017
PhDThe Health Impacts of Hazelwood Coal Fire Particles2017
PhDThe Impact of Mechanical Lung Ventilation on Systemic Inflammation and Lung Injury2019
PhDThe Latrobe Early Life Follow-up Anonymised Data Linkage Study: The child health and development stream of the Hazelwood Health Study2019

Completed

DegreeTitleCompleted
PhDUnderstanding the Molecular Epidemiology of Mycobacterium Tuberculosis Infection from Whole-Genome Analyses
Candidate: Sanjay Gautam
2019
PhDThe Potential Therapeutic Benefits of rhPON2 Against Pseudomonas Aeruginosa Infections
Candidate: Joanne Carmen Pagnon
2018