Profiles

Guna Karupiah

Associate Professor Guna Karupiah

Guna Karupiah

Associate Professor in Biomedicine

Room 241 , Hobart CBD Campuses

+61 6226 2658 (phone)

Guna.Karupiah@utas.edu.au

If you, or someone you love, seek treatment for influenza or viral pneumonia more than 48 hours after the onset of symptoms, no specific cure is currently available. Sadly, this reality will mean death for many previously healthy people, as it did for many Australians during the 2017 flu season. But there may be hope.

Extending the reach of antivirals and treatment for viral pneumonia

Dr Guna Karupiah, Associate Professor of Biomedicine in the UTAS School of Medicine, is an expert in immunology and virology. He has devoted his career to researching the immune response to pox and influenza virus infections. In a major breakthrough, Dr Karupiah’s latest research has revealed that antivirals will effectively treat influenza pneumonia long after 48 hours post-onset of symptoms if they are used in combination with anti-inflammatory drugs – at least it has, to date, with mice.

‘One logical conclusion behind these findings is that our immune response is actually preventing these antivirals from working,’ Dr Karupiah said. ‘Inflammation is an important part of the body’s response against any viral infection, and pneumonia is excessive inflammation of the lung, produced when the immune system goes out of control. If it’s a new strain of virus, which our body has not been exposed to previously, the immune system overreacts to control the infection and inadvertently causes a lot of damage through inflammation. That is where the anti-inflammatories can be effective.

‘We will need to do more animal experiments to ensure that our findings are robust and reproducible. The next step would be to get funding for clinical trials in humans. That’s a while away, but it’s a big finding because we’ve been able to demonstrate it in two different viral models. If we reduce inflammation long after the onset of symptoms, we can actually make the antivirals work.’

Drawing on previous research

Dr Karupiah has extensive experience in working with mousepox, an excellent small animal surrogate model for smallpox. The mousepox model has been crucial to understanding why the smallpox virus killed up to 40 per cent of infected individuals. The mousepox virus is a mouse pathogen and has co-evolved with mice, just as the smallpox virus has co-evolved with humans. Both viruses have close similarities in terms of respiratory infection, disease and pathogenesis and are also in the same virus family.

Based on the success of the mousepox model, which provided an insight into the pathogenesis of viral infections, Dr Karupiah applied some of the findings to his research into influenza pneumonia. As had been shown by others previously, the antiviral drugs didn’t work in mice in the influenza model post-onset of symptoms, just like they don’t in humans. But when anti-inflammatory drugs were used in combination with the antivirals, the mice could be treated and fully recovered. The anti-inflammatory drugs that were used are already available for use in humans.

‘I decided to work on the antivirals because there is a huge gap in what is needed,’ Dr Karupiah said. ‘There is a lot of research in laboratories around the world in making vaccines more effective, but there’s not much going on in terms of how we can treat an individual who is already infected and presents to a doctor long after the onset of symptoms.

‘So there is a lack of treatment for people who are infected with influenza and develop pneumonia, but this problem is not unique to influenza. We’ve done this research with the mousepox model as well. We also know that, for example, the chickenpox virus can be reactivated as shingles in some adults, but the antivirals don’t work if those individuals present to a doctor 48 to 72 hours post-onset of symptoms. So my thinking is that what we’ve been able to show with the pox virus and the influenza virus models is probably going to be applicable to other viral infections as well.’

Since joining UTAS in 2016, Dr Karupiah has also been teaching in the School of Medicine. Previously he worked as a postdoctoral fellow at the National Institutes of Health (NIH, USA) at the Laboratory of Viral Diseases and then the Laboratory of Immunopathology, before returning to Australia to lead successful labs at the University of Sydney and the Australian National University.

Associate Professor Guna Karupiah (Guna) is internationally regarded as an expert on immunity to pox and other generalized viral infections. The significance and impact of his research is evidenced by the highly competitive fellowships he has held, invitations to national and international conferences and workshops, invitations to expert or advisory panels, professional activities and peer review involvement.

His current interests and research projects are immunological memory (humoral immunity), viral infection induced immunopathology (viral pneumonia, cytokine storm) and viral immune evasion.

Biography

Guna trained as a microbiologist (BSc Hons) and then specialised in medical virology and epidemiology (MSc) at the University of Malaya. After completing his PhD in viral immunology at the John Curtin School of Medical Research (JCSMR), Australian National University (ANU), he worked as a postdoctoral fellow at the National Institutes of Health (NIH, USA) at the Laboratory of Viral Diseases and then the Laboratory of Immunopathology. After returning to Australia, has headed successful labs at the University of Sydney and the ANU. He joined the School of Medicine, University of Tasmania in January 2016.

Career summary

Qualifications

PhD	Immunobiology of infection with recombinant vaccinia virus encoding murine IL-2	Australian National University	Australia	1990
MSc	Rapid diagnosis and epidemiology of dengue virus infections in Malaysia	University of Malaya	Malaysia	1986
BSc (Hons)	A biochemical and serological survey of the dengue virus epidemic in Malaysia	University of Malaya	Malaysia	1983
Senior Fellow of the Higher Education Academy, UK		Australian National University	Australia	2014

Languages (other than English)

Malay, Tamil, Indonesian

Memberships

Professional practice

American Society for Microbiology
American Association of Immunologists
American Society for Virology
Australasian Society for Immunology

Administrative expertise

Guna has managed a large National Institutes of Health funded research program on high-throughput screens of mice to reveal genes that confer resistance and susceptibility to class A pathogens (Poxvirus).

Teaching

Viral Immunology; Immunology; Virology; Immunopathology; Viral pneumonia; Vaccines and vaccination strategies; Immune evasion by viruses; Poxviruses; Influenza A virus; Cell-mediated immunity; Antibody responses; Cytokines; Leukocyte subsets.

Teaching expertise

Viral Immunology, Immunology, Virology
Design of 3^rd year BSc Molecular Immunology course at the Australian National University

Teaching responsibility

Master of Medical Research (M7V) Course Coordinator
Basic Pathologic Processes and Immunity (CJA212) Unit Coordinator
Advanced Research Skills (CAM306) Unit Coordinator
Advanced Immunology (CJA314)
Medical Microbiology (CJA313)
Foundations of Medicine 1 (CAM101)
Foundations of Medicine 2 (CAM102)
Fundamentals of Clinical Science 1 (CAM201)
Functional Clinical Practice (CAM305)

View more on AssocProf Guna Karupiah in WARP

Expertise

Novel treatment of viral pneumonia
New strategies for viral vaccine design
Understanding how the immune system works in health and disease
Poxvirus pathogenesis
Smallpox and Mousepox
Immune Evasion

Research Themes

Guna’s research aligns with the University’s research theme of Better Health.The long-standing focus of his research has been to understand the mechanics of an optimal immune response to viral infection with the ultimate goal of developing new efficacious vaccines and ways of intervening in the disease process if infection takes hold. As the host immune response has co-evolved with pathogens, meaningful investigations require appropriate virus-host models and this principle has guided his work. He strongly believes that understanding immune mechanisms at the molecular level through basic research using animal models is a key for translation into innovative and usable outcomes for treating infectious diseases in humans.

Collaboration

1. Modulation of the immune response by virus-encoded cytokine homologs

Dr. Geeta Chaudhri, Australian National University
Professor Mark Buller, St. Louis University, St Louis, USA
Professor Antonio Alcami, Centro de Biología Molecular Severo Ochoa, Madrid, Spain

2. Induction of long-lived antiviral humoral immunity

Dr. Geeta Chaudhri, Australian National University
Dr. Timothy Newsome, School of Molecular Bioscience, University of Sydney
Professor Robert Brink, Garvan Institute for Medical Research, Sydney

3. Systems approach to immunity and inflammation

Professor Richard Ulevitch, Scripps Research Institute, La Jolla, USA
Professor Bruce Beutler, University of Texas Southwestern, USA
Professor Alan Aderem, Seattle Biomed, Seattle, USA
Professor Garry Nolan, Stanford University, California, USA
Professor Christopher Goodnow, Garvan Institute for Medical Research, Sydney

4. Pathophysiological significance of reverse signalling through membrane TNF

Dr. Geeta Chaudhri, Australian National University
Professor Antonio Alcami, Centro de Biología Molecular Severo Ochoa, Madrid, Spain

5. Viral and host schlafen genes in inflammation and immunity to virus infection

Professor Bruce Beutler, University of Texas Southwestern, USA
Professor Antonio Alcami, Centro de Biología Molecular Severo Ochoa, Madrid, Spain

Awards

NHMRC Senior Research Fellowship
Howard Hughes Medical Institute International Research Fellowship, USA
University of Sydney Medical Foundation Fellowship
John E. Fogarty Research Fellowship, National Institutes of Health, USA

Current projects

1. Why do live viral vaccines induce life-long, protective antibody responses?

Vaccination with live viral vaccines provides life-long immunity. In contrast, inactivated vaccines induce short-lived antibody responses. In this project, the molecular and cellular basis for these differences will be investigated, utilizing novel recombinant viruses as well as transgenic, mutant and wild type mice to address some fundamental questions in immunology. It will involve techniques in immunology, virology, molecular biology and proteomics. This project is relevant for developing improved vaccination strategies.

2. A novel approach to treatment of viral pneumonia

Viral infection-induced pneumonia is a consequence of an over-exuberant immune response associated with dysregulated inflammatory cytokine production. There are no specific treatments available for viral pneumonia. We have developed a novel regime for treatment of viral pneumonia and preliminary results indicate that a combination of an antiviral plus a second compound is very effective in significantly reducing viral load, lung pathology and increasing survival even if treatment is started after onset of symptoms. This project will investigate the mechanisms through which the combination therapy ameliorates pneumonia and will assess the effectiveness of additional compounds. The project will utilize various strains of influenza A virus, wild type, gene knockout and gene knockin mice and will involving immunology, virology, molecular biology, cell signaling and histopathology techniques.

3. Mechanisms of protection of the host by virus-encoded TNF receptor homolog

Tumor necrosis factor (TNF) is a type II transmembrane cytokine (mTNF) expressed on activated cells and cleaved by a metalloproteinase to yield the soluble form (sTNF). Poxviruses encode TNF receptor (vTNFR) homologs of the extracellular domain of mammalian TNFR, which can potentially subvert the host immune response. Ectromelia virus (ECTV), an orthopoxvirus closely related to variola virus (smallpox virus) and a natural mouse pathogen, encodes a vTNFR that is secreted. This project will investigate how vTNFR modulates the host response using genetically engineered mutant viruses and gene knockout/knockin mice. It will use immunology, virology, molecular biology and cell signaling techniques. This project is highly relevant to anti-TNF therapies currently used to treat chronic inflammatory diseases.

4. Mouse and viral schlafen genes in infection and immunity

Some members of the family of human and mouse schlafen (Slfn) genes are involved in the activation and differentiation of immune cells. The mechanisms through which the Slfn proteins mediate their activities or the proteins they interact with are not known. Variola virus (VARV, the causative agent of smallpox in humans) and ectromelia virus (ECTV), a mouse-specific virus causing a smallpox-like disease (mousepox) are both poxviruses, which encode homologs of the mammalian schlafen genes. This project will investigate the mechanisms through which viral schlafen gene expression modulates the host immune response. It will utilize novel, genetically engineered mutant viruses and gene knockout/knockin mice involving immunology, virology, molecular biology and cell signaling techniques.

Fields of Research

Innate immunity (320407)
Cellular immunology (320404)
Medical virology (320705)
Virology (310706)
Immunology (320499)
Humoural immunology and immunochemistry (320405)
Medical biotechnology diagnostics (incl. biosensors) (320602)
Cellular interactions (incl. adhesion, matrix, cell wall) (310105)
Cell metabolism (310103)
Medical bacteriology (320701)
Bacteriology (310701)
Autoimmunity (320403)
Molecular evolution (310510)
Transplantation immunology (320408)
Respiratory diseases (320103)
Tumour immunology (320409)
Veterinary diagnosis and diagnostics (300904)
Conservation and biodiversity (410401)
Wildlife and habitat management (410407)

Research Objectives

Prevention of human diseases and conditions (200104)
Clinical health (200199)
Treatment of human diseases and conditions (200105)
Efficacy of medications (200102)
Expanding knowledge in the health sciences (280112)
Control of pests, diseases and exotic species in terrestrial environments (180602)
Human pain management (200103)
Diagnosis of human diseases and conditions (200101)

Publications

Guna Karupiah has 64 publications, and has edited a book on Gamma Interferon in Antiviral Defense. His published papers appear in world class refereed journals that have an average impact factor of 7.2, placing them in the top 3.3% of international journals in the 2015 SCI Journal Citation Reports. His publications have been cited over 3,800 times as reported by the ISI Science Citation Index. In the last 5 years, his published papers have appeared in world class refereed journals that are in the top 2.5 percentile of international journals.

Total publications

Journal Article

(68 outputs)

Year	Citation	Altmetrics
2023	Pandey P, Al Rumaih Z, Tuazon Kels MJ, Ng E, KC R, et al., 'Therapeutic targeting of inflammation and virus simultaneously ameliorates influenza pneumonia and protects from morbidity and mortality', Viruses, 15 pp. 1-18. ISSN 1999-4915 (2023) [Refereed Article] DOI: 10.3390/v15020318 [eCite] [Details] Co-authors: Pandey P; KC R; Malley R Tweet
2022	Pandey P, Al Rumaih Z, Tuazon Kels MJ, Ng E, Kc R, et al., 'Targeting ectromelia virus and TNF/NF-κB or STAT3 signaling for effective treatment of viral pneumonia', Proceedings of the National Academy of Sciences of The United States of America, 119, (8) Article e2112725119. ISSN 0027-8424 (2022) [Refereed Article] DOI: 10.1073/pnas.2112725119 [eCite] [Details] Citations: Scopus - 4Web of Science - 3 Co-authors: Pandey P; Kc R Tweet
2020	Al Rumaih Z, Kels MJT, Ng E, Pandey P, Pontejo SM, et al., 'Poxvirus-encoded TNF receptor homolog dampens inflammation and protects from uncontrolled lung pathology during respiratory infection', National Academy of Sciences of The United States of America. Proceedings, 117, (43) pp. 26885-26894. ISSN 0027-8424 (2020) [Refereed Article] DOI: 10.1073/pnas.2004688117 [eCite] [Details] Citations: Scopus - 4Web of Science - 4 Co-authors: Pandey P Tweet
2020	Gowripalan A, Abbott CR, McKenzie C, Chan WS, Karupiah G, et al., 'Cell-to-cell spread of vaccinia virus is promoted by TGF-β-independent Smad4 signalling', Cellular Microbiology Online, 22, (8) pp. 1-18. ISSN 1462-5822 (2020) [Refereed Article] DOI: 10.1111/cmi.13206 [eCite] [Details] Citations: Scopus - 5Web of Science - 5 Tweet
2020	KC R, Hyland IK, Smith JA, Shukla SD, Hansbro PM, et al., 'Cow dung biomass smoke exposure increases adherence of respiratory pathogen nontypeable Haemophilus infuenzae to human bronchial epithelial cells', Exposure and Health, 12 pp. 883-895. ISSN 2451-9766 (2020) [Refereed Article] DOI: 10.1007/s12403-020-00351-y [eCite] [Details] Citations: Scopus - 4Web of Science - 4 Co-authors: KC R; Hyland IK; Smith JA; Zosky GR; O'Toole RF Tweet
2020	KC R, Leong KWC, Harkness NM, Lachowicz J, Gautam SJ, et al., 'Whole-genome analyses reveal gene content differences between nontypeable Haemophilus influenzae isolates from chronic obstructive pulmonary disease compared to other clinical phenotypes', Microbial Genomics, 6, (8) pp. 1-12. ISSN 2057-5858 (2020) [Refereed Article] DOI: 10.1099/mgen.0.000405 [eCite] [Details] Citations: Scopus - 6Web of Science - 6 Co-authors: KC R; Gautam SJ Tweet
2020	KC R, Leong KWC, McEwan B, Lachowicz J, Harkness NM, et al., 'Draft genome sequence of an isolate of nontypeable Haemophilus influenzae from an acute exacerbation of chronic obstructive pulmonary disease in Tasmania', Microbiology Resource Announcements, 9, (19) pp. 1-2. ISSN 2576-098X (2020) [Refereed Article] DOI: 10.1128/MRA.00375-20 [eCite] [Details] Citations: Scopus - 2Web of Science - 1 Co-authors: KC R; O'Toole RF Tweet
2020	Tuazon Kels MJ, Ng E, Al Rumaih Z, Pandey P, Ruuls SR, et al., 'TNF deficiency dysregulates inflammatory cytokine production, leading to lung pathology and death during respiratory poxvirus infection', Proceedings of the National Academy of Sciences of the United States of America, 117, (27) pp. 15935-15946. ISSN 0027-8424 (2020) [Refereed Article] DOI: 10.1073/pnas.2004615117 [eCite] [Details] Citations: Scopus - 17Web of Science - 17 Co-authors: Pandey P; Korner H Tweet
2019	Eldi P, Chaudhri G, Nutt SL, Newsome TP, Karupiah G, 'Viral replicative capacity, antigen availability via hematogenous spread, and high T_FH:T_FR ratios drive induction of potent neutralizing antibody responses', Journal of Virology, 93, (6) pp. 1-17. ISSN 0022-538X (2019) [Refereed Article] DOI: 10.1128/JVI.01795-18 [eCite] [Details] Citations: Scopus - 4Web of Science - 4 Tweet
2019	Zammit NW, Siggs OM, Gray PE, Horikawa K, Langley DB, et al., 'Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity', Nature Immunology, 20, (10) pp. 1299-1310. ISSN 1529-2908 (2019) [Refereed Article] DOI: 10.1038/s41590-019-0492-0 [eCite] [Details] Citations: Scopus - 35Web of Science - 35 Tweet
2018	Chaudhri G, Kaladimou G, Pandey P, Karupiah G, 'Propagation and Purification of Ectromelia Virus', Current Protocols in Microbiology, 51, (1) ISSN 1934-8525 (2018) [Refereed Article] DOI: 10.1002/cpmc.65 [eCite] [Details] Citations: Scopus - 3 Co-authors: Pandey P Tweet
2018	Duncan ML, Horsington J, Eldi P, Al Rumaih Z, Karupiah G, et al., 'Loss of actin-based motility impairs ectromelia virus release in vitro but is not critical to spread in vivo', Viruses, 10, (3) Article 11. ISSN 1999-4915 (2018) [Refereed Article] DOI: 10.3390/v10030111 [eCite] [Details] Citations: Scopus - 3Web of Science - 3 Tweet
2018	Zanker D, Pang K, Oveissi S, Lu C, Faou P, et al., 'LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins', Immunology and Cell Biology, 96, (9) pp. 981-993. ISSN 0818-9641 (2018) [Refereed Article] DOI: 10.1111/imcb.12163 [eCite] [Details] Citations: Scopus - 3Web of Science - 3 Tweet
2015	Chaudhri G, Tahiliani V, Eldi P, Karupiah G, 'Vaccine-Induced Protection against Orthopoxvirus Infection Is Mediated through the Combined Functions of CD4 T Cell-Dependent Antibody and CD8 T Cell Responses', Journal of Virology, 89, (3) pp. 1889-1899. ISSN 1098-5514 (2015) [Refereed Article] DOI: 10.1128/JVI.02572-14 [eCite] [Details] Citations: Scopus - 13Web of Science - 11 Tweet
2015	Sakala IG, Chaudhri G, Scalzo AA, Eldi P, Newsome TP, et al., 'Evidence for Persistence of Ectromelia Virus in Inbred Mice, Recrudescence Following Immunosuppression and Transmission to Naive Mice', PLoS pathogens, 11, (12) pp. 1-26. ISSN 1553-7366 (2015) [Refereed Article] DOI: 10.1371/journal.ppat.1005342 [eCite] [Details] Citations: Scopus - 8Web of Science - 8 Tweet
2015	Sakala IG, Chaudri G, Eldi P, Buller RM, Karupiah G, 'Deficiency in Th2 Cytokine Responses Exacerbate Orthopoxvirus Infection', PloS one, 10, (3) Article e0118685. ISSN 1932-6203 (2015) [Refereed Article] DOI: 10.1371/journal.pone.0118685 [eCite] [Details] Citations: Scopus - 7Web of Science - 7 Tweet
2014	Andoniou CE, Sutton VR, Wikstrom ME, Fleming P, Thia KY, et al., 'A Natural Genetic Variant of Granzyme B Confers Lethality to a Common Viral Infection', PLoS pathogens, 10, (12) pp. 1-13. ISSN 1553-7366 (2014) [Refereed Article] DOI: 10.1371/journal.ppat.1004526 [eCite] [Details] Citations: Scopus - 15Web of Science - 13 Tweet
2013	Gatto D, Wood K, Caminschi I, Murphy-Durland D, Schofield P, et al., 'The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells', Nature Immunology, 14, (5) pp. 446-453. ISSN 1529-2908 (2013) [Refereed Article] DOI: 10.1038/ni.2555 [eCite] [Details] Citations: Scopus - 136Web of Science - 132 Tweet
2013	Horsington J, Lynn H, Turnbull L, Cheng D, Braet F, et al., 'A36-dependent Actin Filament Nucleation Promotes Release of Vaccinia Virus', PLoS pathogens, 9, (3) pp. 1-15. ISSN 1553-7366 (2013) [Refereed Article] DOI: 10.1371/journal.ppat.1003239 [eCite] [Details] Citations: Scopus - 32Web of Science - 27 Tweet
2013	Tahiliani V, Chaudri G, Eldi P, Karupiah G, 'The orchestrated functions of innate leukocytes and T cell subsets contribute to humoral immunity, virus control, and recovery from secondary poxvirus challenge', Journal of Virology, 87, (7) pp. 3852-61. ISSN 0022-538X (2013) [Refereed Article] DOI: 10.1128/JVI.03038-12 [eCite] [Details] Citations: Scopus - 8Web of Science - 8 Tweet
2012	Chang PP, Lee SK, Hu X, Davey G, Duan G, et al., 'Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells', Journal of Immunology, 189, (2) pp. 701-10. ISSN 0022-1767 (2012) [Refereed Article] DOI: 10.4049/jimmunol.1102432 [eCite] [Details] Citations: Scopus - 20Web of Science - 18 Tweet
2012	Lynn H, Horsington J, Ter LK, Han S, Chew YL, et al., 'Loss of Cytoskeletal Transport during Egress Critically Attenuates Ectromelia Virus Infection In Vivo', Journal of Virology (Online), 86, (13) pp. 7427-7443. ISSN 1098-5514 (2012) [Refereed Article] DOI: 10.1128/JVI.06636-11 [eCite] [Details] Citations: Scopus - 19Web of Science - 18 Tweet
2011	Haque A, Best SE, Unosson K, Amante FH, de Labastida F, et al., 'Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria', Journal of Immunology, 186, (11) pp. 6148-56. ISSN 0022-1767 (2011) [Refereed Article] DOI: 10.4049/jimmunol.1003955 [eCite] [Details] Citations: Scopus - 138Web of Science - 136 Tweet
2010	O'Gorman WE, Sampath P, Simonds EF, Sikorski R, O'Malley M, et al., 'Alternate mechanisms of initial pattern recognition drive differential immune responses to related poxviruses', Cell Host and Microbe, 8, (2) pp. 174-185. ISSN 1931-3128 (2010) [Refereed Article] DOI: 10.1016/j.chom.2010.07.008 [eCite] [Details] Citations: Scopus - 23Web of Science - 23 Tweet
2010	Panchanathan V, Chaudhri G, Karupiah G, 'Antiviral protection following immunization correlates with humoral but not cell-mediated immunity', Immunology and Cell Biology, 88, (4) pp. 461-467. ISSN 0818-9641 (2010) [Refereed Article] DOI: 10.1038/icb.2009.110 [eCite] [Details] Citations: Scopus - 24Web of Science - 21 Tweet
2009	Chaudhri G, Quah BJ, Wang Y, Tan AHY, Zhou J, et al., 'T cell receptor sharing by cytotoxic T lymphocytes facilitates efficient virus control', National Academy of Sciences of The United States of America. Proceedings, 106, (35) pp. 14984-9. ISSN 0027-8424 (2009) [Refereed Article] DOI: 10.1073/pnas.0906554106 [eCite] [Details] Citations: Scopus - 30Web of Science - 28 Tweet
2009	Wang Y, Chaudhri G, Jackson RJ, Karupiah G, 'IL-12p40 and IL-18 play pivotal roles in orchestrating the cell-mediated immune response to a poxvirus infection', Journal of Immunology, 183, (5) pp. 3324-3331. ISSN 0022-1767 (2009) [Refereed Article] DOI: 10.4049/jimmunol.0803985 [eCite] [Details] Citations: Scopus - 47Web of Science - 43 Tweet
2007	Karupiah G, Chaudhri G, 'Immunopathogenesis of infectious disease: injury and death from friendly fire', 85, (1) ISSN 0818-9641 (2007) [Edited Journal] DOI: 10.1038/sj.icb.7100016 [eCite] [Details] Citations: Scopus - 4Web of Science - 4 Tweet
2007	Sakala IG, Chaudhri G, Buller RM, Nuara AA, Bai H, et al., 'Poxvirus-encoded gamma interferon binding protein dampens the host immune response to infection', Journal of Virology, 81, (7) pp. 3346-3353. ISSN 0022-538X (2007) [Refereed Article] DOI: 10.1128/JVI.01927-06 [eCite] [Details] Citations: Scopus - 32Web of Science - 31 Tweet
2006	Chaudhri G, Panchanathan V, Bluethmann H, Karupiah G, 'Obligatory requirement for antibody in recovery from a primary poxvirus infection', Journal of Virology, 80, (13) pp. 6339-6344. ISSN 0022-538X (2006) [Refereed Article] DOI: 10.1128/JVI.00116-06 [eCite] [Details] Citations: Scopus - 87Web of Science - 78 Tweet
2006	Jayasekera JP, Vinuesa GG, Karupiah G, King NJC, 'Enhanced antiviral antibody secretion and attenuated immunopathology during influenza virus infection in nitric oxide synthase-2-deficient mice', Journal of General Virology, 87, (Pt11) pp. 3361-3371. ISSN 0022-1317 (2006) [Refereed Article] DOI: 10.1099/vir.0.82131-0 [eCite] [Details] Citations: Scopus - 35Web of Science - 30 Tweet
2006	Panchanathan V, Chaudhri G, Karupiah G, 'Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function', Journal of Virology, 80, (13) pp. 6333-8. ISSN 0022-538X (2006) [Refereed Article] DOI: 10.1128/JVI.00115-06 [eCite] [Details] Citations: Scopus - 98Web of Science - 91 Tweet
2006	Tscharke DC, Woo W-P, Sakala IG, Sidney J, Sette A, et al., 'Poxvirus CD8+ T-Cell determinants and cross-reactivity in BALB/c mice', Journal of Virology, 80, (13) pp. 6318-6323. ISSN 0022-538X (2006) [Refereed Article] DOI: 10.1128/JVI.00427-06 [eCite] [Details] Citations: Scopus - 99Web of Science - 94 Tweet
2005	Panchanathan V, Chaudhri G, Karupiah G, 'Interferon function is not required for recovery from a secondary poxvirus infection', Proceedings of the National Academy of Sciences, 102, (36) pp. 12921-6. ISSN 0027-8424 (2005) [Refereed Article] DOI: 10.1073/pnas.0505180102 [eCite] [Details] Citations: Scopus - 47Web of Science - 44 Tweet
2005	Tscharke DC, Karupiah G, Zhou J, Palmore T, Irvine KR, et al., 'Identification of poxvirus CD8⁺ T cell determinants to enable rational design and characterization of smallpox vaccines', The Journal of Experimental Medicine, 201, (1) pp. 95-104. ISSN 0022-1007 (2005) [Refereed Article] DOI: 10.1084/jem.20041912 [eCite] [Details] Citations: Scopus - 257Web of Science - 248 Tweet
2004	Belz GT, Smith CM, Eichner D, Shortman K, Karupiah G, et al., 'Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses', Journal of Immunology, 172, (4) pp. 1996-2000. ISSN 0022-1767 (2004) [Refereed Article] DOI: 10.4049/jimmunol.172.4.1996 [eCite] [Details] Citations: Scopus - 260Web of Science - 244 Tweet
2004	Chaudhri G, Panchanathan V, Buller RML, van den Eertwegh AJM, Claassen E, et al., 'Polarized type 1 cytokine response and cell-mediated immunity determine genetic resistance to mousepox', Proceedings of the National Academy of Sciences, 101, (24) pp. 9057-62. ISSN 0027-8424 (2004) [Refereed Article] DOI: 10.1073/pnas.0402949101 [eCite] [Details] Citations: Scopus - 95Web of Science - 91 Tweet
2004	Kunzelmann K, Konig J, Sun J, Markovich D, King NJ, et al., 'Acute effects of parainfluenza virus on epithelial electrolyte transport', Journal of Biological Chemistry, 279, (47) pp. 48760 -48766. ISSN 0021-9258 (2004) [Refereed Article] DOI: 10.1074/jbc.M409747200 [eCite] [Details] Citations: Scopus - 36Web of Science - 35 Tweet
2001	Foxwell AR, Kyd JM, Karupiah G, Cripps AW, 'CD8+ T cells have an essential role in pulmonary clearance of nontypeable Haemophilus influenzae following mucosal immunization', Infection and Immunity, 69, (4) pp. 2636-42. ISSN 0019-9567 (2001) [Refereed Article] DOI: 10.1128/IAI.69.4.2636-2642.2001 [eCite] [Details] Citations: Scopus - 15Web of Science - 14 Tweet
2001	Mahalingam S, Chaudhri G, Tan CL, John A, Foster PS, et al., 'Transcription of the interferon gamma (IFN-gamma )-inducible chemokine Mig in IFN-gamma-deficient mice', Journal of Biological Chemistry, 276, (10) pp. 7568-7574. ISSN 0021-9258 (2001) [Refereed Article] DOI: 10.1074/jbc.M005773200 [eCite] [Details] Citations: Scopus - 30Web of Science - 31 Tweet
2001	Mahalingam S, Karupiah G, Takeda K, Akira S, Matthaei KI, et al., 'Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus', National Academy of Sciences of The United States of America. Proceedings, 98, (12) pp. 6812-6817. ISSN 0027-8424 (2001) [Refereed Article] DOI: 10.1073/pnas.111151098 [eCite] [Details] Citations: Scopus - 24Web of Science - 22 Tweet
2000	Kunzelmann K, Beesley A, King N, Karupiah G, Young J, et al., 'Unexpected effects of pathogens on epithelial Na⁺ channels', Journal of Korean Medical Science, 15 pp. S59-60. ISSN 1011-8934 (2000) [Refereed Article] DOI: 10.3346/jkms.2000.15.S.S59 [eCite] [Details] Tweet
2000	Kunzelmann K, Beesley AH, King NJ, Karupiah G, Young JA, et al., 'Influenza virus inhibits amiloride-sensitive Na+ channels in respiratory epithelia', National Academy of Sciences of The United States of America. Proceedings, 97, (18) pp. 10282-10287. ISSN 0027-8424 (2000) [Refereed Article] DOI: 10.1073/pnas.160041997 [eCite] [Details] Citations: Scopus - 112Web of Science - 102 Tweet
2000	Mahalingam S, Karupiah G, 'Expression of the interferon-inducible chemokines MuMig and Crg-2 following vaccinia virus infection in vivo', Immunology and Cell Biology, 78, (2) pp. 156-160. ISSN 0818-9641 (2000) [Professional, Refereed Article] DOI: 10.1046/j.1440-1711.2000.00894.x [eCite] [Details] Citations: Scopus - 8Web of Science - 8 Tweet
2000	Scalzo AA, Farrell HE, Karupiah G, 'Techniques for studying murine natural killer cells in defense against viral infection', Methods in Molecular Biology, 121 pp. 163-77. ISSN 1064-3745 (2000) [Professional, Refereed Article] DOI: 10.1385/1-59259-044-6:163 [eCite] [Details] Citations: Scopus - 13 Tweet
1999	Mahalingam S, Farber JM, Karupiah G, 'The Interferon-Inducible Chemokines MuMig and Crg-2 Exhibit Antiviral Activity In Vivo', Journal of Virology, 73, (2) pp. 1479-1491. ISSN 1098-5514 (1999) [Refereed Article] DOI: 10.1128/JVI.73.2.1479-1491.1999 [eCite] [Details] Citations: Web of Science - 94 Tweet
1999	Simeonovic CJ, Townsend MJ, Karupiah G, Wilson JD, Zarb JC, et al., 'Analysis of the Th1/Th2 paradigm in transplantation: interferon-gamma deficiency converts Th1-type proislet allograft rejection to a Th2-type xenograft-like response', Cell Transplantation, 8, (4) pp. 365-73. ISSN 0963-6897 (1999) [Refereed Article] DOI: 10.1177/096368979900800404 [eCite] [Details] Citations: Scopus - 31Web of Science - 30 Tweet
1999	Xiong Y, Karupiah G, Hogan SP, Foster PS, Ramsay AJ, 'Inhibition of allergic airway inflammation in mice lacking nitric oxide synthase 2', Journal of Immunology, 162, (1) pp. 445-452. ISSN 0022-1767 (1999) [Refereed Article] PMID: 9886418 [eCite] [Details] Citations: Web of Science - 120 Tweet
1998	Karupiah G, Chen J-H, Mahalingam S, Nathan CF, MacMicking JD, 'Rapid Interferon g-dependent Clearance of Influenza A Virus and Protection from Consolidating Pneumonitis in Nitric Oxide Synthase 2-deficient Mice', The Journal of Experimental Medicine, 188, (8) pp. 1541-1546. ISSN 0022-1007 (1998) [Refereed Article] DOI: 10.1084/jem.188.8.1541 [eCite] [Details] Citations: Scopus - 163Web of Science - 154 Tweet
1998	Karupiah G, Chen J-H, Nathan CF, Mahalingam S, MacMicking JD, 'Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection', Journal of Virology, 79, (2) pp. 7703-7706. ISSN 0022-538X (1998) [Refereed Article] DOI: 10.1128/JVI.72.9.7703-7706.1998 [eCite] [Details] Citations: Web of Science - 49 Tweet
1998	Karupiah G, Sacks TE, Klinman DM, Fredrickson TN, Hartley JW, et al., 'Murine Cytomegalovirus Infection-Induced Polyclonal B Cell Activation Is Independent of CD41 T Cells and CD40', Virology, 240, (1) pp. 12-26. ISSN 0042-6822 (1998) [Refereed Article] DOI: 10.1006/viro.1997.8900 [eCite] [Details] Citations: Scopus - 36Web of Science - 33 Tweet
1997	Ramshaw IA, Ramsay AJ, Karupiah G, Rolph MS, Mahalingam RS, et al., 'Cytokines and immunity to viral infections', Immunological Reviews, 159 pp. 119-135. ISSN 0105-2896 (1997) [Refereed Article] DOI: 10.1111/j.1600-065x.1997.tb01011.x [eCite] [Details] Citations: Web of Science - 222 Tweet
1996	Amichay D, Gazzinelli RT, Karupiah G, Moench TR, Sher A, et al., 'Genes for chemokines MuMig and Crg-2 are induced in protozoan and viral infections in response to IFN-gamma with patterns of tissue expression that suggest nonredundant roles in vivo', Journal of Immunology, 157, (10) pp. 4511-4520. ISSN 0022-1767 (1996) [Refereed Article] PMID: 8906829 [eCite] [Details] Citations: Web of Science - 130 Tweet
1996	Karupiah G, Buller RML, Van Rooijen N, Duarte CL, Chen J, 'Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection', Journal of Virology, 70, (12) pp. 8301-8309. ISSN 0022-538X (1996) [Refereed Article] DOI: 10.1128/JVI.70.12.8301-8309.1996 [eCite] [Details] Citations: Scopus - 155Web of Science - 148 Tweet
1995	Harris N, Buller RM, Karupiah G, 'Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication', Journal of Virology, 69, (2) pp. 910-915. ISSN 0022-538X (1995) [Refereed Article] DOI: 10.1128/JVI.69.2.910-915.1995 [eCite] [Details] Citations: Scopus - 152Web of Science - 151 Tweet
1995	Karupiah G, Harris N, 'Inhibition of viral replication by nitric oxide and its reversal by ferrous sulfate and tricarboxylic acid cycle metabolites', The Journal of Experimental Medicine, 181, (6) pp. 2171-2179. ISSN 0022-1007 (1995) [Refereed Article] DOI: 10.1084/jem.181.6.2171 [eCite] [Details] Citations: Scopus - 96Web of Science - 96 Tweet
1994	Cox JH, Buller RM, Bennink JR, Yewdell JW, Karupiah G, 'Expression of adenovirus E3/19K protein does not alter mouse MHC class I-restricted responses to vaccinia virus', Virology, 204, (2) pp. 558-62. ISSN 0042-6822 (1994) [Refereed Article] DOI: 10.1006/viro.1994.1569 [eCite] [Details] Citations: Scopus - 15Web of Science - 16 Tweet
1993	Karupiah G, Fredrickson TN, Holmes KL, Khairallah LH, Buller RM, 'Importance of interferons in recovery from mousepox', Journal of Virology, 67, (7) pp. 4214-26. ISSN 0022-538X (1993) [Refereed Article] DOI: 10.1128/JVI.67.7.4214-4226.1993 [eCite] [Details] Citations: Scopus - 144Web of Science - 140 Tweet
1993	Karupiah G, Xie QW, Buller RM, Nathan C, Duarte C, et al., 'Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase', Science, 261, (5127) pp. 1445-8. ISSN 0036-8075 (1993) [Refereed Article] DOI: 10.1126/science.7690156 [eCite] [Details] Citations: Scopus - 752Web of Science - 760 Tweet
1992	Karupiah G, Ramsay AJ, Ramshaw IA, Blanden RV, 'Recombinant vaccine vector-induced protection of athymic, nude mice from influenza A virus infection. Analysis of protective mechanisms', Scandinavian Journal of Immunology, 36, (1) pp. 99-105. ISSN 0300-9475 (1992) [Refereed Article] DOI: 10.1111/j.1365-3083.1992.tb02945.x [eCite] [Details] Citations: Scopus - 13Web of Science - 13 Tweet
1992	Ramshaw I, Ruby J, Ramsay A, Ada G, Karupiah G, 'Expression of cytokines by recombinant vaccinia viruses: a model for studying cytokines in virus infections in vivo', Immunological Reviews, 127 pp. 157-182. ISSN 0105-2896 (1992) [Refereed Article] DOI: 10.1111/j.1600-065x.1992.tb01413.x [eCite] [Details] Citations: Web of Science - 141 Tweet
1991	Andrew ME, Karupiah G, Boyle DB, Blanden RV, Mullbacher A, et al., 'Effects of vaccinia virus-expressed interleukin 2 on the immune system of sublethally irradiated mice', Microbial Pathogenesis, 10, (5) pp. 363-71. ISSN 0882-4010 (1991) [Refereed Article] DOI: 10.1016/0882-4010(91)90081-k [eCite] [Details] Citations: Scopus - 3Web of Science - 2 Tweet
1991	Karupiah G, Woodhams CE, Blanden RV, Ramshaw IA, 'Immunobiology of infection with recombinant vaccinia virus encoding murine IL-2. Mechanisms of rapid viral clearance in immunocompetent mice', Journal of Immunology, 147, (12) pp. 4327-32. ISSN 0022-1767 (1991) [Refereed Article] PMID: 1684375 [eCite] [Details] Citations: Web of Science - 28 Tweet
1990	Karupiah G, Blanden RV, 'Anti-asialo-GM1 inhibits vaccinia virus infection of murine ovaries: asialo-GM1 as an additional virus receptor?', Immunology and Cell Biology, 68, (Pt 5) pp. 343-6. ISSN 0818-9641 (1990) [Refereed Article] DOI: 10.1038/icb.1990.46 [eCite] [Details] Citations: Web of Science - 13 Tweet
1990	Karupiah G, Blanden RV, Ramshaw IA, 'Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection', The Journal of Experimental Medicine, 172, (5) pp. 1495-503. ISSN 0022-1007 (1990) [Refereed Article] DOI: 10.1084/jem.172.5.1495 [eCite] [Details] Citations: Scopus - 94Web of Science - 115 Tweet
1990	Karupiah G, Coupar B, Ramshaw I, Boyle D, Blanden R, et al., 'Vaccinia virus-mediated damage of murine ovaries and protection by virus-expressed interleukin-2', Immunology and Cell Biology, 68, (Pt 5) pp. 325-333. ISSN 0818-9641 (1990) [Refereed Article] DOI: 10.1038/icb.1990.44 [eCite] [Details] Citations: Web of Science - 34 Tweet
1990	Karupiah G, Coupar BE, Andrew ME, Boyle DB, Phillips SM, et al., 'Elevated natural killer cell responses in mice infected with recombinant vaccinia virus encoding murine IL-2', Journal of Immunology, 144, (1) pp. 290-8. ISSN 0022-1767 (1990) [Refereed Article] PMID: 2295796 [eCite] [Details] Citations: Web of Science - 108 Tweet
1988	Gunasegaran K, Lam SK, Pang T, 'Modification and improvement of the haemadsorption immunosorbent technique (HIT) for the detection of dengue IgM antibodies', The Malaysian Journal of Pathology, 10 pp. 73-7. ISSN 0126-8635 (1988) [Refereed Article] PMID: 3252082 [eCite] [Details] Tweet

Book

(1 outputs)

Year	Citation	Altmetrics
1997	Karupiah G, 'Gamma Interferon in Antiviral Defense', Chapman & Hall, United States, pp. 192. ISBN 0412130416 (1997) [Edited Book] [eCite] [Details]

Chapter in Book

(4 outputs)

Year	Citation	Altmetrics
2007	Karupiah G, Panchanathan V, Sakala IG, Chaudhri G, 'Genetic resistance to smallpox: lessons from mousepox', Decoding the Genomic Control of Immune Reactions, Wiley, GR Bock and JA Goode (ed), United States, pp. 129-140. ISBN 978-0-470-02755-4 (2007) [Research Book Chapter] DOI: 10.1002/9780470062128.ch11 [eCite] [Details] Citations: Scopus - 7 Tweet
1997	Ada G, Karupiah G, 'Overview of Host Defense Mechanisms with Special Reference to Viral Infections', Gamma Interferon in Antiviral Defense, Chapman & Hall, G Karupiah (ed), United States, pp. 1-18. ISBN 0412130416 (1997) [Research Book Chapter] [eCite] [Details]
1997	Karupiah G, Harris N, 'Gamma Interferon-Induced Nitric Oxide in Antiviral Defense and Immunopathology', Gamma Interferon in Antiviral Defense, Chapman & Hall, G Karupiah (ed), United States, pp. 119-142. ISBN 0412130416 (1997) [Research Book Chapter] [eCite] [Details]
1989	Ramshaw IA, Sambhi S, Karupiah G, Kohonen-Corish M, Ruby J, et al., 'Vaccinia-Directed Cytokine Gene Expression and Infection', Immunology of Virus Diseases, John Curtin School of Medical Research, RV Blanden (ed), Australia, pp. 35-46. ISBN 0958830991 (1989) [Research Book Chapter] [eCite] [Details]

Review

(8 outputs)

Year	Citation	Altmetrics
2021	Pandey P, Karupiah G, 'Targeting tumour necrosis factor to ameliorate viral pneumonia', The FEBS Journal pp. 1-18. ISSN 1742-464X (2021) [Substantial Review] DOI: 10.1111/febs.15782 [eCite] [Details] Citations: Scopus - 9Web of Science - 2 Co-authors: Pandey P Tweet
2008	Panchanathan V, Chaudhri G, Karupiah G, 'Correlates of protective immunity in poxvirus infection: where does antibody stand?', Immunology and Cell Biology, 86, (1) pp. 80-6. ISSN 0818-9641 (2008) [Substantial Review] DOI: 10.1038/sj.icb.7100118 [eCite] [Details] Citations: Scopus - 73Web of Science - 61 Tweet
2007	Stanford MM, McFadden G, Karupiah G, Chaudhri G, 'Immunopathogenesis of poxvirus infections: forecasting the impending storm', Immunology and Cell Biology, 85, (2) pp. 93-102. ISSN 0818-9641 (2007) [Substantial Review] DOI: 10.1038/sj.icb.7100033 [eCite] [Details] Citations: Scopus - 77Web of Science - 62 Tweet
2000	Karupiah G, Hunt NH, King NJ, Chaudhri G, 'NADPH oxidase, Nramp1 and nitric oxide synthase 2 in the host antimicrobial response', Reviews In Immunogenetics, 2, (3) pp. 387-415. ISSN 1398-1714 (2000) [Substantial Review] PMID: 11256747 [eCite] [Details] Tweet
2000	Mahalingam S, Foster PS, Lobigs M, Farber JM, Karupiah G, 'Interferon-inducible chemokines and immunity to poxvirus infections', Immunological Reviews, 177 pp. 127-33. ISSN 0105-2896 (2000) [Substantial Review] DOI: 10.1034/j.1600-065x.2000.17720.x [eCite] [Details] Citations: Web of Science - 20 Tweet
2000	Mahalingam S, Karupiah G, 'Modulation of chemokines by poxvirus infections', Current Opinion in Immunology, 12, (4) pp. 409-12. ISSN 0952-7915 (2000) [Substantial Review] DOI: 10.1016/s0952-7915(00)00109-6 [eCite] [Details] Citations: Scopus - 26Web of Science - 26 Tweet
1999	Mahalingam S, Karupiah G, 'Chemokines and chemokine receptors in infectious diseases', Immunology and Cell Biology, 77, (6) pp. 469-75. ISSN 0818-9641 (1999) [Substantial Review] DOI: 10.1046/j.1440-1711.1999.00858.x [eCite] [Details] Citations: Scopus - 96Web of Science - 89 Tweet
1998	Karupiah G, 'Type 1 and type 2 cytokines in antiviral defense', Veterinary Immunology and Immunopathology, 63, (1-2) pp. 105-9. ISSN 0165-2427 (1998) [Substantial Review] DOI: 10.1016/s0165-2427(98)00086-5 [eCite] [Details] Citations: Scopus - 55Web of Science - 53 Tweet

Grants & Funding

Guna Karupiah has held prestigious fellowships such as the Fogarty Fellowship (National Institutes of Health (NIH, USA)); the Medical Foundation Fellowship (University of Sydney); and International Research Scholar of the Howard Hughes Medical Institute (HHMI, USA), and has been successful in obtaining national and international competitive research grants. Since 1999, he has obtained individual and collaborative grants totalling over $10 million.

Funding Summary

Number of grants

Total funding

$89,630,225

Projects

ICG - GREYSCAN PTY LTD (2020)$259,020

Description: With GreyScan will repurpose the ETD-100 trace explosives system to detect viruses and create a new product range, TVD 1
Funding: GreyScan Pty Ltd ($259,020)
Scheme: Contract Research
Administered By: University of Tasmania
Research Team: Breadmore MC; King AE; Karupiah G; Flies AS; Wilson CR; Flies E; Gell DA
Year: 2020

Novel combination therapy for effective virus control and amelioration of influenza pneumonia (2019)$23,875

Description: There is currently no treatment available for viral pneumonia. We have developed a novel combination therapy for effective control and amelioration of influenza pneumonia. The drugs we use are currently used in humans, however not for the purpose described in the application. We do not yet know the mechanisms through which the combination treatment affords protection, and if the drugs can be administered through the respiratory route to treat influenza pneumonia effectively.We do not yet know the mechanisms through which the combination treatment affords protection, and whether the drugs can be administered through the respiratory route to treat influenza pneumonia effectively. These questions form the basis of the application. An understanding of both the mechanism(s) through which the treatment works, as well as determining an effective and practical route of delivery, will result in targeted, efficacious, and feasible clinical solutions to treatment of influenza pneumonia.
Funding: The MPST Foundation Ltd ($23,875)
Scheme: Grant
Administered By: University of Tasmania
Research Team: Karupiah G
Year: 2019

Systems Approach to Immunity and Inflammation (2012 - 2016)$31,000,000

Funding: National Institutes of Health (NIH), USA ($31,000,000)
Scheme: U19 Program grant (NIH U19 RFA-AI-017)
Administered By: Australian National University (ANU), The Scripps Research Institute (TSRI), Seattle Biomed (SB), University of Texas Southwestern (UTSW), Stanford University (SU)
Research Team: Ulevitch R; Goodnow C; Karupiah G; Aderem A; Beutler B; Nolan G
Period: 2012 - 2016

Regulation of leukocyte migration and interaction by the homing receptor EBI2 (2011 - 2013)$493,654

Funding: National Health and Medical Research Council ($493,654)
Scheme: Project grant (APP1003025)
Administered By: Garvan Institute for Medical Research (Garvan) and Australian National University (ANU)
Research Team: Gatto D; Pha T; Karupiah G
Period: 2011 - 2013

Understanding the key attributes of CD8 T cell receptor transfer as an antiviral strategy and harnessing the process to combat persistent viral infections (2011 - 2013)$591,732

Funding: National Health and Medical Research Council ($591,732)
Scheme: Project grant (APP1007980)
Administered By: Australian National University (ANU)
Research Team: Karupiah G; Chaudhri G
Period: 2011 - 2013

Antiviral targeting of motility (2010 - 2012)$318,817

Funding: National Health and Medical Research Council ($318,817)
Scheme: Project Grant
Administered By: University of Sydney (USyd); Australian National University (ANU)
Research Team: Newsome T; Karupiah G
Period: 2010 - 2012

A novel strategy to regulate host antiviral immune response and inflammation through mTNF (2008 - 2010)$568,501

Funding: National Health and Medical Research Council ($568,501)
Scheme: Project Grant
Administered By: Australian National University (ANU)
Research Team: Chaudhri G; Karupiah G
Period: 2008 - 2010

Systems Approach to Immunity and Inflammation (2007 - 2011)$51,000,000

Funding: National Institutes of Health (NIH), USA ($51,000,000)
Scheme: NIH Program grant (HHSN272200700038C)
Administered By: Australian National University (ANU), The Scripps Research Institute (TSRI), Seattle Biomed (SB), University of Texas Southwestern (UTSW), Stanford University (SU)
Research Team: Ulevitch R; Goodnow C; Karupiah G; Aderem A; Beutler B; Nolan G
Period: 2007 - 2011

Immunity to viral infections (2007 - 2011)$616,452

Funding: National Health and Medical Research Council ($616,452)
Scheme: NHMRC Fellowship (SRF B)
Administered By: Australian National University (ANU)
Research Team: Karupiah G
Period: 2007 - 2011

CD8+ T cell responses in mouse models of smallpox vaccination and challenge (2007 - 2009)$968,000

Funding: National Institutes of Health (NIH), USA ($968,000)
Scheme: NIH RO1 grant
Administered By: Australian National University (ANU); University of Washington in St Louis (WU)
Research Team: Tscharke D; Karupiah G; Buller M
Period: 2007 - 2009

Immunity to viral infections (2007 - 2011)$558,000

Funding: National Health and Medical Research Council ($558,000)
Scheme: NHMRC Fellowship (SRF B) (GNT0179830)
Administered By: Australian National University (ANU)
Research Team: Karupiah G
Period: 2007 - 2011

Role of plasmacytoid dendritic cells and neutrophils in the generation of antiviral immunity (2005 - 2007)$469,500

Funding: National Health and Medical Research Council ($469,500)
Scheme: Project grant
Administered By: Australian National University
Research Team: Karupiah G
Period: 2005 - 2007

Critical role of TNF in host-virus interactions and outcome of infection: Involvement of reverse signalling through mTNF (2004 - 2006)$496,500

Funding: National Health and Medical Research Council ($496,500)
Scheme: Project grant (GNT0268037)
Administered By: Australian National University (ANU)
Research Team: Chaudhri G; Karupiah G
Period: 2004 - 2006

Critical soluble effector molecules causing immune damage in a model of West Nile virus encephalitis (2003 - 2005)$250,500

Funding: National Health and Medical Research Council ($250,500)
Scheme: Project grant (GNT0253771)
Administered By: Australian National University (ANU); University of Sydney (USyd)
Research Team: King N; Karupiah G; Kesson A; Chaudhri G
Period: 2003 - 2005

Pathophysiological significance of reverse signalling through membrane TNF (2001 - 2003)$453,055

Funding: National Health and Medical Research Council ($453,055)
Scheme: Project grant (GNT0153835)
Administered By: Australian National University (ANU)
Research Team: Chaudhri G; KArupiah G
Period: 2001 - 2003

Control of influenza A virus infection by gamma interferon-inducible mediators (2001 - 2003)$227,036

Funding: National Health and Medical Research Council ($227,036)
Scheme: Project grant (GNT0153836)
Administered By: Australian National University (ANU)
Research Team: Karupiah G
Period: 2001 - 2003

Immunity to viral infections (2000 - 2004)$450,000

Funding: The Howard Hughes Medical Institute (USA) ($450,000)
Scheme: International Research Fellowship
Administered By: Australian National University (ANU)
Research Team: Karupiah G
Period: 2000 - 2004

Role of nitric oxide in influenza A virus-induced pneumonia (1999 - 2001)$390,583

Funding: National Health and Medical Research Council ($390,583)
Scheme: Project grant (GNT0990583)
Administered By: University of Sydney (USyd)
Research Team: Karupiah G; King N
Period: 1999 - 2001

Models of human viral disease: Role of nitric oxide and chemokines in the pathogenesis of lethal pneumonia and encephalitis as a basis for interventive drug development (1999 - 2001)$495,000

Funding: University of Sydney Medical Foundation ($495,000)
Scheme: Fellowship
Administered By: University of Sydney (USyd)
Research Team: Karupiah G; King N
Period: 1999 - 2001

Research Supervision

Guna is involved in a diverse range of teaching activities. He has extensive tertiary teaching experience in the forms of supervision of Honours, Higher Degree Research and postgraduate medical research students, undergraduate lecturing and research supervision, and international postdoctoral and postgraduate training. Since 1998, he has trained 2 Research Fellows, 5 Postdoctoral Fellows, 15 PhD students and 11 Honours students. In recognition of his contribution to teaching, training and mentoring students, he was recognised as a Senior Fellow of the Higher Education Academy, United Kingdom (2014).

He has a number of exciting Honours and PhD projects (see Current Research Projects).

Current

Completed

Current

Degree	Title	Commenced
PhD	Surgical and Anaesthetic Comorbidity in Animal Models of Stroke: A veil over effective drug development	2022

Completed

Degree	Title	Completed
PhD	Novel Approach to Treat Viral Pneumonia Candidate: Pratikshya Pandey	2022
PhD	Exploring Molecular Mechanisms Underlying the Role of Non-typeable Haemophilus influenzae in COPD Candidate: Rajendra KC	2020