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Nicole Bye

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Nicole Bye

Lecturer

Room 4011, Pharmacy

+61 6226 1032 (phone)

Nicole.Bye@utas.edu.au

Dr Bye is a lecturer in the school of medicine, teaching neuroscience and pharmacology. Her research focuses on cellular regeneration after traumatic brain injury, as well as imaging techniques and quantitative approaches to measure inflammation and cellular repair in the aftermath of injury. Prior to her current position Dr Bye held a series of fellowships during her extensive experience in laboratory neuroscience research, and maintains collaborations around Australia. She is also an experienced research mentor at undergraduate and postgraduate levels.

Biography

During an eleven-year term as a research scientist in the laboratory of the National Trauma Research Institute at the Alfred Hospital, Dr Bye completed her PhD working with A/Prof Cristina Morganti-Kossmann, establishing a range of advanced imaging techniques and animal models of brain injury. Following her PhD she was awarded an Early Career Researcher Fellowship by the Victorian Neurotrauma Initiative, before securing half a million dollars in funding from the Transport Accident Commission to investigate the possibility of post-injury regeneration by stimulating the birth of new neurons.

Career summary

Qualifications

  • PhD (Monash University), 2006. Thesis: Gene expression and effects of TGF-ß1 in relation to apoptosis and neurogenesis in adult rat hippocampus.
  • BSc(Hons) (Monash University)

Memberships

Professional practice

  • Australasian Neuroscience Society
  • International Neurotrauma Society

Administrative expertise

  • Dr Bye coordinates units and is part of the management team for the Bachelor of Pharmacy.

Teaching

Pharmacology of the ANS, CNS and immune system; neuroscience; brain injury; neuroinflammation; regeneration; research methodology and project design

Teaching responsibility

Unit Coordinator

Lecturer

View more on Dr Nicole Bye in WARP

Expertise

  • animal models of traumatic brain injury
  • neuroinflammation
  • post-traumatic neurogenesis

Research Themes

Dr Bye is a nationally prominent researcher in the field of traumatic brain injury (TBI). TBI represents a considerable and life-changing burden to the people injured, their families and friends, and the health care system. Recovery from TBI is often slow and difficult, and in many cases individuals are left with a permanent loss of function. This is because the brain heals very differently to other body tissues, and the process of rebuilding is not yet well understood. Her research focuses on regenerative responses after traumatic brain injury, with a particular interest in the role of neuroinflammation in regulating neurogenesis in the injured cortex. Guiding and shaping this process to produce useful functional replacements is a major goal for successful rehabilitation. She is also investigating the therapeutic potential of novel anti-inflammatory drugs being developed by collaborators in the division of Pharmacy.

Her work employs a range of techniques including the pioneering use of nanoparticles as inflammatory markers, drug discovery and evaluation, small animal MRI, confocal microscopy and unbiased tissue quantitation methods. In addition to her technical expertise, she has extensive experience in undergraduate and postgraduate research supervision.

Dr Bye’s research aligns to the University’s research theme of Better Health.

Awards

  • Awarded an Adjunct Senior Research Fellow position with the Department of Surgery, Monash University, April 2013 – March 2014
  • Awarded an Early Career Researcher Fellowship from the Victorian Neurotrauma Initiative, February 2009 – January 2012

Fields of Research

  • Central Nervous System (110903)
  • Neurosciences (110999)
  • Nanobiotechnology (100703)
  • Biologically Active Molecules (030401)
  • Cellular Nervous System (110902)

Research Objectives

  • Nervous System and Disorders (920111)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Human Biological Preventatives (e.g. Vaccines) (860801)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Expanding Knowledge in the Biological Sciences (970106)

Publications

Total publications

17

Journal Article

(17 outputs)
YearCitationAltmetrics
2018Hellewell SC, Mondello S, Conquest A, Shaw G, Madorsky I, et al., 'Erythropoietin Does Not Alter Serum Profiles of Neuronal and Axonal Biomarkers After Traumatic Brain Injury: Findings From the Australian EPO-TBI Clinical Trial', Critical care medicine, 46, (4) pp. 554-561. ISSN 0090-3493 (2018) [Refereed Article]

DOI: 10.1097/CCM.0000000000002938 [eCite] [Details]

Citations: Web of Science - 35

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2018Morganti-Kossmann MC, Semple BD, Hellewell SC, Bye N, Ziebell JM, 'The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments', Acta Neuropathologica pp. 1-25. ISSN 0001-6322 (2018) [Refereed Article]

DOI: 10.1007/s00401-018-1944-6 [eCite] [Details]

Citations: Scopus - 14Web of Science - 10

Co-authors: Ziebell JM

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2017Nhiem Tran N, Bye N, Moffat BA, Wright DK, Cuddihy A, et al., 'Dual-modality NIRF-MRI cubosomes and hexosomes: High throughput formulation and in vivo biodistribution', Materials Science & Engineering C-Materials for Biological Applications, 71 pp. 584-593. ISSN 0928-4931 (2017) [Refereed Article]

DOI: 10.1016/j.msec.2016.10.028 [eCite] [Details]

Citations: Scopus - 21Web of Science - 20

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2017Woodcock TM, Frugier T, Nguyen TT, Semple BD, Bye N, et al., 'The scavenging chemokine receptor ACKR2 has a significant impact on acute mortality rate and early lesion development after traumatic brain injury', PLoS one, 12, (11) Article e0188305. ISSN 1932-6203 (2017) [Refereed Article]

DOI: 10.1371/journal.pone.0188305 [eCite] [Details]

Citations: Scopus - 4Web of Science - 3

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2016Basrai HS, Christie KJ, Turbic A, Bye N, Turnley AM, 'Suppressor of cytokine Signaling-2 (SOCS2) regulates the microglial response and improves functional outcome after traumatic brain injury in mice', PloS One, 11, (14) Article e0153418. ISSN 1932-6203 (2016) [Refereed Article]

DOI: 10.1371/journal.pone.0153418 [eCite] [Details]

Citations: Scopus - 13Web of Science - 12

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2016Bye N, Christie KJ, Turbic A, Basrai HS, Turnley AM, 'Rho kinase inhibition following traumatic brain injury in mice promotes functional improvement and acute neuron survival but has little effect on neurogenesis, glial responses or neuroinflammation', Experimental Neurology, 279 pp. 86-95. ISSN 0014-4886 (2016) [Refereed Article]

DOI: 10.1016/j.expneurol.2016.02.012 [eCite] [Details]

Citations: Scopus - 7Web of Science - 9

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2016Frugier T, Taylor JM, McLean C, Bye N, Beart PM, et al., 'Evidence for the recruitment of autophagic vesicles in human brain after stroke', Neurochemistry international, 96 pp. 62-68. ISSN 0197-0186 (2016) [Refereed Article]

DOI: 10.1016/j.neuint.2016.02.016 [eCite] [Details]

Citations: Scopus - 9Web of Science - 8

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2015Dent KA, Christie KJ, Bye N, Basrai HS, Turbic A, et al., 'Oligodendrocyte birth and death following traumatic brain injury in adult mice', PloS one, 10, (3) Article e0121541. ISSN 1932-6203 (2015) [Refereed Article]

DOI: 10.1371/journal.pone.0121541 [eCite] [Details]

Citations: Scopus - 24Web of Science - 22

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2014Bye N, Hutt OE, Hinton TM, Acharya DP, Waddington LJ, et al., 'Nitroxide-loaded hexosomes provide MRI contrast in vivo', Langmuir, 30, (29) pp. 8898-8906. ISSN 0743-7463 (2014) [Refereed Article]

DOI: 10.1021/la5007296 [eCite] [Details]

Citations: Scopus - 28Web of Science - 26

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2014Goh CP, Putz U, Howitt J, Low LH, Gunnersen J, et al., 'Nuclear trafficking of Pten after brain injury leads to neuron survival not death', Experimental neurology, 252 pp. 37-46. ISSN 0014-4886 (2014) [Refereed Article]

DOI: 10.1016/j.expneurol.2013.11.017 [eCite] [Details]

Citations: Scopus - 15Web of Science - 16

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2014Tarlac V, Kelly L, Anderson RP, Bye N, Storey E, 'Coeliac disease patients do not produce antibodies to a common cerebellar epitope', Cerebellum & Ataxias, 1 Article 18. ISSN 2053-8871 (2014) [Refereed Article]

DOI: 10.1186/s40673-014-0018-3 [eCite] [Details]

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2014Yan EB, Satgunaseelan L, Paul E, Bye N, Nguyen P, et al., 'Post-Traumatic Hypoxia Is Associated with Prolonged Cerebral Cytokine Production, Higher Serum Biomarker Levels, and Poor Outcome in Patients with Severe Traumatic Brain Injury', Journal of Neurotrauma, 31, (7) pp. 618-629. ISSN 0897-7151 (2014) [Refereed Article]

DOI: 10.1089/neu.2013.3087 [eCite] [Details]

Citations: Scopus - 41Web of Science - 41

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2013Hellewell S, Yan EB, Alwis DS, Bye N, Morganti-Kossmann MC, 'Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor', Journal of Neuroinflammation, 10 pp. 1-21. ISSN 1742-2094 (2013) [Refereed Article]

DOI: 10.1186/1742-2094-10-156 [eCite] [Details]

Citations: Scopus - 40Web of Science - 38

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2012Bye N, Turnley AM, Morganti-Kossmann C, 'Inflammatory Regulators of Redirected Neural Migration in the Injured Brain', Neurosignals, 20, (3) pp. 132-146. ISSN 1424-862X (2012) [Refereed Article]

DOI: 10.1159/000336542 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

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2012Ng SY, Semple BD, Morganti-Kossman MC, Bye N, 'Attenuation of Microglial Activation with Minocycline Is Not Associated with Changes in Neurogenesis after Focal Traumatic Brain Injury in Adult Mice', Journal of neurotrauma, 29, (7) pp. 1410-1425. ISSN 0897-7151 (2012) [Refereed Article]

DOI: 10.1089/neu.2011.2188 [eCite] [Details]

Citations: Scopus - 38Web of Science - 34

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2011Bye N, Carron S, Han X, Aqyapomaa D, Ng SY, et al., 'Neurogenesis and Glial Proliferation Are Stimulated Following Diffuse Traumatic Brain Injury in Adult Rats', Journal of neuroscience research, 89, (7) pp. 986-1000. ISSN 0360-4012 (2011) [Refereed Article]

DOI: 10.1002/jnr.22635 [eCite] [Details]

Citations: Scopus - 52Web of Science - 49

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2011Ziebell JM, Bye N, Semple BD, Kossmann T, Morganti-Kossmann MC, 'Attenuated neurological deficit, cell death and lesion volume in Fas-mutant mice is associated with altered neuroinflammation following traumatic brain injury', Brain research, 1414 pp. 94-105. ISSN 0006-8993 (2011) [Refereed Article]

DOI: 10.1016/j.brainres.2011.07.056 [eCite] [Details]

Citations: Scopus - 32Web of Science - 29

Co-authors: Ziebell JM

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Grants & Funding

Funding Summary

Number of grants

1

Total funding

$10,000

Projects

Investigating the anti-inflammatory effect of a non-anticoagulant molecule of heparin following experimental traumatic brain injury (2017)$10,000
Description
Heparin has shown promising results in attenuating neuroinflammation following experimental traumatic brain injury (TBI); however, its anti-coagulative properties make it an unsuitable treatment due to the risk of bleeding. We have recently shown that the heparin derivative Dp4 retains the anti-inflammatory actions of heparin, but not the anti-coagulative properties. In this project, we will test whether Dp4 suppresses neuroinflammation following TBI in mice, potentially identifying it as a novel and valuable therapeutic agent for brain-injured patients.
Funding
Royal Hobart Hospital Research Foundation ($10,000)
Scheme
Grant-Starter
Administered By
University of Tasmania
Research Team
Bye N; Taylor BVM; Patel RP
Year
2017

Research Supervision

Current

1

Completed

1

Current

DegreeTitleCommenced
PhDEvaluating theTherapeutic Potential of Novel Idebenone Formulations Following Experimental Traumatic Brain Injury2017

Completed

DegreeTitleCompleted
PhDPharmacological Modulation of Mood, Behaviour and Cognition
Candidate: Xin Yin
2018