Yong Song

UTAS Home Dr Yong Song

Yong Song

Research Fellow

Hobart CBD Campuses

Dr Song is a highly experienced respiratory scientist with more than 10-year experience in studying lung diseases. Specifically, his research interest is focused on investigating acute and chronic lung injury associating with mechanical ventilation, environmental health, and the early life origins.


Before joining the University of Tasmania, Dr Song worked as a full-time academic at Murdoch University (2008-2010), University of Western Australia (2010-2016), and Curtin University (2016-2019). Since 2016 and 2019, he has been also holding a position of Adjunct Senior Research Fellow at the University of Western Australia and Curtin University respectively.

Career summary


  • GradCert in Research Management, Southern Cross University 2009
  • PhD in Biomedical Sciences Murdoch University, Australia, 2008
  • GradDip in Information Technology University of Canberra 2002
  • MSc in Respiratory Medicine, Lanzhou University, Medical College, 1999
  • M.D at Jianghan University, Medical College, 1996

Languages (other than English)

Mandarin (native), English


Professional practice

Member: European Respiratory Society (ERS) Member: The Thoracic Society of Australia and New Zealand (TSANZ) Member: Asian Pacific Society of Respirology (APSR) Member: Perinatal Society of Australia & New Zealand (PSANZ)

Administrative expertise

Laboratory management and Biosafety representative (2016-2019)

Research Appointments

Since 2012, Dr Song has been an external reviewer for grant application of NHMRC and ARC.

View more on Dr Yong Song in WARP


During his academic career, Dr Song has established and managed two research laboratories and developed a series of cellular, molecular and biochemical assays to study cell signalling, inflammation, oxidative stress and mitochondrial dysfunction, the genome and epigenome and the interaction between the microbiome and immunity in the lung. His strong expertise in molecular/cellular biology is also evidenced by the successful commercialization of an immunological kit, 2 genotyping kits and patents on 8 genes for vaccine/therapeutic targets during his early postdoctoral period.

Research Themes

Dr Song’s research aligns to the University’s research theme of Better Health. His research interests include 1) understanding the mechanisms underlying acute/chronic lung diseases, including investigation of the impact of in utero exposures (inflammation, steroid, etc.) on the respiratory system, and mechanical ventilation - induced lung and diaphragm injury, and 2) studies on environmental health and gene-environment interactions in lung diseases (e.g., asthma, allergy, etc.).


His achievements in the respiratory field are recognised by a number of awards such as the Asian Pacific Society of Respirology Young Investigator Award in 2012 and Japanese Respiratory Society (JRS) Young Investigator Award in 2013, and are highlighted by an invitation to chair a symposium on “Breath and Clinical Problems” at the 54th Annual Meeting of the JRS.

Fields of Research

  • Respiratory diseases (320103)
  • Foetal development and medicine (321501)
  • Medical bacteriology (320701)
  • Paediatrics (321399)
  • Bacteriology (310701)
  • Cell development, proliferation and death (310102)
  • Epigenetics (incl. genome methylation and epigenomics) (310504)
  • Signal transduction (310111)
  • Immunology (320499)
  • Central nervous system (320903)
  • Cardiology (incl. cardiovascular diseases) (320101)
  • Biological network analysis (310202)
  • Gastroenterology and hepatology (320209)
  • Cancer cell biology (321101)
  • Medical virology (320705)
  • Infectious agents (310702)
  • Veterinary medicine (excl. urology) (300907)
  • Biochemistry and cell biology (310199)
  • Environmental management (410499)

Research Objectives

  • Clinical health (200199)
  • Prevention of human diseases and conditions (200104)
  • Other health (209999)
  • Diagnosis of human diseases and conditions (200101)
  • Public health (excl. specific population health) (200499)
  • Treatment of human diseases and conditions (200105)
  • Expanding knowledge in the biological sciences (280102)
  • Other animal production and animal primary products (109999)
  • Behaviour and health (200401)


Dr Song has published 32 peer-reviewed articles, (18 as first and/or corresponding author) and 32 conference abstracts. Most of his findings are published in high-quality respiratory journals, such as Eur Respir J, J Appl Physiol, Am J Respir Cell Mol Biol.

Total publications


Journal Article

(40 outputs)
2023Song Y, Chen L, Bennett E, Wheeler AJ, Southam K, et al., 'Can maternal exposure to air pollution affect post-natal liver development?', Toxics, 11, (1) pp. 1-9. ISSN 2305-6304 (2023) [Refereed Article]

DOI: 10.3390/toxics11010061 [eCite] [Details]

Co-authors: Bennett E; Wheeler AJ; Southam K; Yen S; Johnston F; Zosky GR


2022Lee KH, Bosco A, O'Sullivan M, Song Y, Metcalfe J, et al., 'Identifying gene network patterns and associated cellular immune responses in children with or without nut allergy', World Allergy Organization Journal, 15, (2) Article 100631. ISSN 1939-4551 (2022) [Refereed Article]

DOI: 10.1016/j.waojou.2022.100631 [eCite] [Details]


2022Song Y, Southam K, Beamish BB, Zosky GR, 'Effects of chemical composition on the lung cell response to coal particles: Implications for coal workers' pneumoconiosis', Respirology pp. 1-8. ISSN 1323-7799 (2022) [Refereed Article]

DOI: 10.1111/resp.14246 [eCite] [Details]

Citations: Scopus - 6Web of Science - 5

Co-authors: Southam K; Zosky GR


2022Song Y, Yen S, Preissner M, Bennett E, Dubsky S, et al., 'The association between regional transcriptome profiles and lung volumes in response to mechanical ventilation and lung injury', Respiratory Research, 23, (1) Article 35. ISSN 1465-993X (2022) [Refereed Article]

DOI: 10.1186/s12931-022-01958-2 [eCite] [Details]

Citations: Scopus - 2

Co-authors: Yen S; Bennett E; Dargaville PA; Zosky GR


2021Lee KH, Guo J, Song Y, Ariff A, O'Sullivan M, et al., 'Dysfunctional gut microbiome networks in childhood IgE-mediated food allergy', International Journal of Molecular Sciences, 22, (4) pp. 1-10. ISSN 1422-0067 (2021) [Refereed Article]

DOI: 10.3390/ijms22042079 [eCite] [Details]

Citations: Scopus - 12Web of Science - 13


2021Schwager MJ, Song Y, Laing IA, Saiganesh A, Guo J, et al., 'Increased nasal Streptococcus pneumoniae presence in Western environment associated with allergic conditions in Chinese immigrants', International Journal of Hygiene and Environmental Health, 234 pp. 1-7. ISSN 1438-4639 (2021) [Refereed Article]

DOI: 10.1016/j.ijheh.2021.113735 [eCite] [Details]

Citations: Scopus - 1


2021Song Y, Walters EH, Abramson MJ, Bowatte G, Bui DS, et al., 'Protein levels, air pollution and vitamin D deficiency: links with allergy', ERJ Open Research, 7, (4) pp. 1-4. ISSN 2312-0541 (2021) [Refereed Article]

DOI: 10.1183/23120541.00237-2021 [eCite] [Details]

Co-authors: Walters EH; Wilson R; Nichols DS; Zosky GR


2020Guo J, Song Y, Saiganesh A, Hales BJ, Bosco A, et al., 'Toll-like receptor signalling has inverted U-shaped response over time with the Western environment', Allergy pp. 1-4. ISSN 0105-4538 (2020) [Refereed Article]

DOI: 10.1111/all.14277 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1


2020Lee KH, Song Y, Wu W, Yu K, Zhang G, 'The gut microbiota, environmental factors, and links to the development of food allergy', Clinical and Molecular Allergy, 18, (1) Article 5. ISSN 1476-7961 (2020) [Refereed Article]

DOI: 10.1186/s12948-020-00120-x [eCite] [Details]

Citations: Scopus - 42


2020Poole A, Song Y, O'Sullivan M, Lee KH, Metcalfe J, et al., 'Children with nut allergies have impaired gene expression of Toll-like receptors pathway', Pediatric Allergy and Immunology pp. 1-7. ISSN 0905-6157 (2020) [Refereed Article]

DOI: 10.1111/pai.13246 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5


2020Shan Y, Guo J, Fan W, Li H, Wu H, et al., 'Modern urbanization has reshaped the bacterial microbiome profiles of house dust in domestic environments', The World Allergy Organization Journal, 13, (8) pp. 1-16. ISSN 1939-4551 (2020) [Refereed Article]

DOI: 10.1016/j.waojou.2020.100452 [eCite] [Details]

Citations: Scopus - 10Web of Science - 9


2020Song Y, Southam K, Bennett E, Johnston F, Foa L, et al., 'Adverse effects of prenatal exposure to residential dust on post-natal brain development', Environmental Research, 198 pp. 1-9. ISSN 0013-9351 (2020) [Refereed Article]

DOI: 10.1016/j.envres.2020.110489 [eCite] [Details]

Citations: Scopus - 1Web of Science - 2

Co-authors: Southam K; Bennett E; Johnston F; Foa L; Wheeler AJ; Zosky GR


2020Yen S, Song Y, Preissner M, Bennett E, Wilson R, et al., 'The proteomic response is linked to regional lung volumes in ventilator-induced lung injury', Journal of Applied Physiology, 129, (4) pp. 837-845. ISSN 8750-7587 (2020) [Refereed Article]

DOI: 10.1152/japplphysiol.00097.2020 [eCite] [Details]

Citations: Scopus - 4Web of Science - 5

Co-authors: Yen S; Bennett E; Wilson R; Pavez M; Dargaville PA; Zosky GR


2019Guo J, Lv Q, Ariff A, Zhang X, Peacock CS, et al., 'Western oropharyngeal and gut microbial profiles are associated with allergic conditions in Chinese immigrant children', World Allergy Organization Journal, 12, (8) Article 100051. ISSN 1939-4551 (2019) [Refereed Article]

DOI: 10.1016/j.waojou.2019.100051 [eCite] [Details]

Citations: Scopus - 7Web of Science - 8

Co-authors: Melton PE; Moses EK


2018Karisnan K, Mahzabin T, Bakker AJ, Song Y, Noble PB, et al., 'Gestational age at time of in utero lipopolysaccharide exposure influences the severity of inflammation-induced diaphragm weakness in lambs', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 314, (4) pp. R523-R532. ISSN 0363-6119 (2018) [Refereed Article]

DOI: 10.1152/ajpregu.00150.2017 [eCite] [Details]

Citations: Web of Science - 2


2018Song Y, Aguilar R, Guo J, Manaca MN, Nhabomba A, et al., 'Cord blood IL-12 confers protection to clinical malaria in early childhood life', Scientific Reports, 8, (1) Article 10860. ISSN 2045-2322 (2018) [Refereed Article]

DOI: 10.1038/s41598-018-29179-y [eCite] [Details]


2018Song Y, Dahl M, Leavitt W, Alvord J, Bradford CY, et al., 'Vitamin A protects the preterm lamb diaphragm against adverse effects of mechanical ventilation', Frontiers in Physiology, 9 Article 1119. ISSN 1664-042X (2018) [Refereed Article]

DOI: 10.3389/fphys.2018.01119 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3


2018Song Y, Higgins H, Guo J, Harrison K, Schultz EN, et al., 'Clinical significance of circulating microRNAs as markers in detecting and predicting congenital heart defects in children', Journal of Translational Medicine, 16, (1) Article 42. ISSN 1479-5876 (2018) [Refereed Article]

DOI: 10.1186/s12967-018-1411-0 [eCite] [Details]

Citations: Scopus - 22Web of Science - 23


2017Hou C, Li W, Li Z, Gao J, Chen Z, et al., 'Synthetic isoliquiritigenin inhibits human tongue squamous carcinoma cells through its antioxidant mechanism', Oxidative Medicine and Cellular Longevity, 2017 Article 1379430. ISSN 1942-0900 (2017) [Refereed Article]

DOI: 10.1155/2017/1379430 [eCite] [Details]

Citations: Scopus - 16Web of Science - 10


2017Mahzabin T, Pillow JJ, Pinniger GJ, Bakker AJ, Noble PB, et al., 'Influence of antenatal glucocorticoid on preterm lamb diaphragm', Pediatric Research, 82, (3) pp. 509-517. ISSN 0031-3998 (2017) [Refereed Article]

DOI: 10.1038/pr.2017.99 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2


2017Song Y, Khoo SK, Lee KH, Makela M, Haahtela T, et al., 'Dual responses of CD14 methylation to distinct environments: a role in asthma and allergy', The European Respiratory Journal, 50, (6) Article 1701228. ISSN 0903-1936 (2017) [Letter or Note in Journal]

DOI: 10.1183/13993003.01228-2017 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3


2017Song Y, Schwager MJ, Backer V, Guo J, Porsbjerg C, et al., 'Environment changes genetic effects on respiratory conditions and allergic phenotypes', Scientific Reports, 7, (1) Article 6342. ISSN 2045-2322 (2017) [Refereed Article]

DOI: 10.1038/s41598-017-06791-y [eCite] [Details]

Citations: Scopus - 10Web of Science - 9


2015Karisnan K, Bakker AJ, Song Y, Noble PB, Pillow JJ, et al., 'Gestational age at initial exposure to in utero inflammation influences the extent of diaphragm dysfunction in preterm lambs', Respirology, 20, (8) pp. 1255-1262. ISSN 1323-7799 (2015) [Refereed Article]

DOI: 10.1111/resp.12615 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4


2015Karisnan K, Bakker AJ, Song Y, Noble PB, Pillow JJ, et al., 'Interleukin-1 receptor antagonist protects against lipopolysaccharide induced diaphragm weakness in preterm lambs', PLoS One, 10, (4) Article e0124390. ISSN 1932-6203 (2015) [Refereed Article]

DOI: 10.1371/journal.pone.0124390 [eCite] [Details]

Citations: Scopus - 8Web of Science - 9


2015Song Y, La T, Phillips ND, Hampson DJ, 'Development of a serological ELISA using a recombinant protein to identify pig herds infected with Brachyspira hyodysenteriae', The Veterinary Journal, 206, (3) pp. 365-370. ISSN 1090-0233 (2015) [Refereed Article]

DOI: 10.1016/j.tvjl.2015.08.021 [eCite] [Details]

Citations: Scopus - 7Web of Science - 5


2015Tingay DG, Polglase GR, Bhatia R, Berry CA, Kopotic RJ, et al., 'Pressure-limited sustained inflation vs. gradual tidal inflations for resuscitation in preterm lambs', Journal of Applied Physiology, 118, (7) pp. 890-897. ISSN 8750-7587 (2015) [Refereed Article]

DOI: 10.1152/japplphysiol.00985.2014 [eCite] [Details]

Citations: Scopus - 27Web of Science - 24


2014Polglase GR, Tingay DG, Bhatia R, Berry CA, Kopotic RJ, et al., 'Pressure- versus volume-limited sustained inflations at resuscitation of premature newborn lambs', BMC Paediatrics, 14 Article 43. ISSN 1471-2431 (2014) [Refereed Article]

DOI: 10.1186/1471-2431-14-43 [eCite] [Details]

Citations: Scopus - 30Web of Science - 26


2014Song Y, Demmer DL, Pinniger GJ, Lavin T, MacMillan MV, et al., 'Effect of maternal steroid on developing diaphragm integrity', PLoS One, 9, (3) Article e93224. ISSN 1932-6203 (2014) [Refereed Article]

DOI: 10.1371/journal.pone.0093224 [eCite] [Details]

Citations: Scopus - 8Web of Science - 7


2013Lavin T, Song Y, Bakker AJ, McLean CJ, Macdonald WA, et al., 'Developmental changes in diaphragm muscle function in the preterm and postnatal lamb', Pediatric Pulmonology, 48, (7) pp. 640-648. ISSN 8755-6863 (2013) [Refereed Article]

DOI: 10.1002/ppul.22762 [eCite] [Details]

Citations: Scopus - 10Web of Science - 9


2013Song Y, Karisnan K, Noble PB, Berry CA, Lavin T, et al., 'In utero LPS exposure impairs preterm diaphragm contractility', American Journal of Respiratory Cell and Molecular Biology, 49, (5) pp. 866-874. ISSN 1535-4989 (2013) [Refereed Article]

DOI: 10.1165/rcmb.2013-0107OC [eCite] [Details]

Citations: Scopus - 15Web of Science - 15


2013Song Y, Pillow JJ, 'Developmental regulation of molecular signalling in fetal and neonatal diaphragm protein metabolism', Experimental Biology and Medicine, 238, (8) Article 913-922. ISSN 1535-3702 (2013) [Refereed Article]

DOI: 10.1177/1535370213494562 [eCite] [Details]

Citations: Scopus - 7Web of Science - 9


2013Song Y, Pinniger GJ, Bakker AJ, Moss TJM, Noble PB, et al., 'Lipopolysaccharide-induced weakness in the preterm diaphragm is associated with mitochondrial electron transport chain dysfunction and oxidative stress', PLoS One, 8, (9) Article e73457. ISSN 1932-6203 (2013) [Refereed Article]

DOI: 10.1371/journal.pone.0073457 [eCite] [Details]

Citations: Scopus - 19Web of Science - 15


2013Yang R, Murphy C, Song Y, Ng-Hublin J, Estcourt A, et al., 'Specific and quantitative detection and identification of Cryptosporidium hominis and C. parvum in clinical and environmental samples', Experimental Parasitology, 135, (1) pp. 142-147. ISSN 0014-4894 (2013) [Refereed Article]

DOI: 10.1016/j.exppara.2013.06.014 [eCite] [Details]

Citations: Scopus - 122Web of Science - 107


2012Musk GC, Polglase GR, Song Y, Pillow JJ, 'Impact of conventional breath inspiratory time during high-frequency jet ventilation in preterm lambs', Neonatology, 101, (4) pp. 267-273. ISSN 1661-7800 (2012) [Refereed Article]

DOI: 10.1159/000334828 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2


2012Song Y, Frey B, Hampson DJ, 'The use of ELISAs for monitoring exposure of pig herds to Brachyspira hyodysenteriae', BMC Veterinary Research, 8 Article 6. ISSN 1746-6148 (2012) [Refereed Article]

DOI: 10.1186/1746-6148-8-6 [eCite] [Details]

Citations: Scopus - 8Web of Science - 7


2012Song Y, Pillow JJ, 'Ontogeny of proteolytic signaling and antioxidant capacity in fetal and neonatal diaphragm', The Anatomical Record, 295, (5) pp. 864-871. ISSN 1932-8486 (2012) [Refereed Article]

DOI: 10.1002/ar.22436 [eCite] [Details]

Citations: Scopus - 11Web of Science - 10


2011Musk GC, Polglase GR, Bunnell JB, McLean CJ, Nitsos I, et al., 'High positive end-expiratory pressure during high-frequency jet ventilation improves oxygenation and ventilation in preterm lambs', Pediatric Research, 69, (4) pp. 319-324. ISSN 0031-3998 (2011) [Refereed Article]

DOI: 10.1203/PDR.0b013e31820bbdf5 [eCite] [Details]

Citations: Scopus - 11Web of Science - 8


2009Naresh R, Song Y, Hampson DJ, 'The intestinal spirochete Brachyspira pilosicoli attaches to cultured Caco-2 cells and induces pathological changes', PLoS One, 4, (12) Article e8352. ISSN 1932-6203 (2009) [Refereed Article]

DOI: 10.1371/journal.pone.0008352 [eCite] [Details]

Citations: Scopus - 30Web of Science - 28


2009Song Y, Hampson DJ, 'Development of a multiplex qPCR for detection and quantitation of pathogenic intestinal spirochaetes in the faeces of pigs and chickens', Veterinary Microbiology, 137, (1-2) pp. 129-136. ISSN 0378-1135 (2009) [Refereed Article]

DOI: 10.1016/j.vetmic.2008.12.020 [eCite] [Details]

Citations: Scopus - 42Web of Science - 41


2009Song Y, La T, Phillips ND, Bellgard MI, Hampson DJ, 'A reverse vaccinology approach to swine dysentery vaccine development', Veterinary Microbiology, 137, (1-2) pp. 111-119. ISSN 0378-1135 (2009) [Refereed Article]

DOI: 10.1016/j.vetmic.2008.12.018 [eCite] [Details]

Citations: Scopus - 22Web of Science - 26



(2 outputs)
2018Poole A, Song Y, Brown H, Hart PH, Zhang GB, 'Cellular and molecular mechanisms of vitamin D in food allergy', Journal of Cellular and Molecular Medicine, 22, (7) pp. 3270-3277. ISSN 1582-1838 (2018) [Substantial Review]

DOI: 10.1111/jcmm.13607 [eCite] [Details]

Citations: Scopus - 28Web of Science - 21


2017Lee KH, Song Y, O'Sullivan M, Pereira G, Loh R, et al., 'The implications of DNA methylation on food allergy', International Archives of Allergy and Immunology, 173, (4) pp. 183-192. ISSN 1018-2438 (2017) [Substantial Review]

DOI: 10.1159/000479513 [eCite] [Details]

Citations: Scopus - 8Web of Science - 7


Conference Publication

(3 outputs)
2018Shan Y, Noble P, York E, Zhang B, Song Y, 'Biological effects of preterm birth on airway development (AO161)', Respirology, pp. 65-66, Vol 23 Suppl. 2. ISSN 1323-7799 (2018) [Conference Extract]

[eCite] [Details]

2014Song Y, Pillow JJ, Bakker AJ, Pinniger GJ, 'Implication of micro RNA in postnatal diaphram dysfunction (A337)', Journal of Paediatrics and Child Health, pp. 32, Vol 50, Suppl. 1. ISSN 1034-4810 (2014) [Conference Extract]

[eCite] [Details]

2012Song Y, Pinniger G, Bakker T, Pillow JJ, 'Molecular mechanisms of preterm diaphram weakness in response to intra-amniotic lipopolysaccharide (102)', Respirology, pp. 25, Vol 17, Suppl. 2. ISSN 1323-7799 (2012) [Conference Extract]

[eCite] [Details]

Grants & Funding

To date, Dr Song has acquired nine research grants (six as CIA).

Funding Summary

Number of grants


Total funding



Biological and pathologic effects of mechanical ventilation on the cardiovascular system (2021)$24,200
Mechanical ventilation is a life-saving strategy in premature babies and critically ill patients, but also contributes to high mortality rates in these patients due to injury in other organs such as the heart. We aim to understand how mechanical ventilation injures the heart in order to improve patient outcomes.
Royal Hobart Hospital Research Foundation ($24,200)
Administered By
University of Tasmania
Research Team
Song Y; Zosky GR; Dargaville PA
The role of particle size in the pathogenesis of engineered stone-associated accelerated silicosis (2021 - 2022)$665,843
The emergence of engineered stone associated silicosis in Australia is an occupational health disaster. While the scale of this problem is unclear, estimates of disease prevalence suggest that 20-30% of workers in this industry have evidence of silicosis. Tragically, this disease is progressive, incurable, is often fatal and is impacting workers who have only been working in the industry for a few years. This is in stark contrast to the historical form of silicosis which develops over a 20-30 year period and has largely been eliminated in Australia. A range of factors are likely to contribute to the severity and short latency period of this new form of silicosis, including the high levels of exposure and silica content of stone. However, this does not entirely explain the disease severity and there remain unanswered questions regarding the enhanced potency of engineered stone dusts that is hampering efforts to reduce the burden of disease and improve outcomes in patients. This project has two broad aims that are targeted at the desired outcomes of this grant opportunity:1)To understand the particle characteristics of dusts generated by processing engineered stone including the particle size distribution and particle chemistry2)To examine the link between particle characteristics and the lung response
Medical Research Future Fund ($665,843)
Grant - 2020 Silicosis Research
Administered By
University of Tasmania
Research Team
Zosky GR; Gaskin S; Song Y; Pisaniello D; Auty J
2021 - 2022

Research Supervision

Dr Song has successfully supervised 2 PhD and 4 Honours students to completion, and currently he is co-supervising another 3 PhD students.




PhDUnderstanding The Mechanisms of Dust Induced Lung Disease2022