Profiles

Carlie Cullen

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Carlie Cullen

Postdoctoral Research Fellow - Neuroscience
Menzies Institute for Medical Research

Hobart CBD Campuses

+61 3 6226 2769 (phone)

+61 3 6226 7704 (fax)

Carlie.Cullen@utas.edu.au

Dr Carlie Cullen is a postdoctoral research fellow in the Glial Research Team at the Menzies Institute for Medical Research. She has a deep interest in how brain connectivity drives cognition and what happens when this system goes awry.

Biography

Carlie joined the glial research team at the Menzies Institute for Medical Research, University of Tasmania, in 2014 as an early career researcher after completing her PhD in cognitive neuroscience at the University of Queensland. Her work on the long term neurobehavioural correlates of low dose prenatal alcohol exposure was well received internationally and she was the first to show that exposure to even small amounts of alcohol in utero can lead to long term morphological changes in the amygdala – the emotion centre of the brain, leading to increased anxiety in adulthood. Following her interest in brain plasticity and cognition, Carlie is now working with Dr Kaylene Young to investigate the how alterations in neuron-glial communication may contribute to neurodegenerative disease, and how this might be therapeutically manipulated to alleviate disease symptoms.

Career summary

Qualifications

  • PhD, The long term neurobehavioural correlates of chronic low dose prenatal alcohol exposure, The University of Queensland, Australia, 2014
  • BSc (1st Class Hons), The effects of chronic glucocorticoid and reproductive steroid hormone manipulations on spatial memory and anxiety, The University of Queensland, 2008

View more on Dr Carlie Cullen in WARP

Expertise

  • Cognition
  • Neurodegenerative disease
  • Demyelinating disease
  • Fetal alcohol exposure

Research Themes

Carlie's research interest include understanding the importance of the continued generation of new born oligodendrocytes for maintaining normal healthy functioning of the adult CNS, how neurons and oligodendrocyte progenitor cells (OPCs) communicate and how this communication might be therapeutically targeted to enhance the generation of new born oligodendrocytes and myelin repair in neurodegenerative or demyelinating diseases.

Collaboration

Local Collaborators:

Dr Catherine Blizzard

Dr Rob Gasperini

A/Prof Lisa Foa

Dr Kimberley Pitman

External Collaborators:

Dr Simon McMullan – Macquarie University

Dr Jenny Roger – University of Western Australia

Dr Tracey Bjorkman – University of Queensland Centre for Clinical ResearchA/Prof Karen Moritz –University of Queensland

Current projects


Glial Research Team: Young Group

  • Neuron:OPC communication, a novel therapeutic target?
  • Non-invasive enhancement of adult oligodendrogenesis
  • The role of oligodendrocyte progenitor cells in neurodegenerative diseas

Fields of Research

  • Central Nervous System (110903)
  • Cellular Nervous System (110902)
  • Neurosciences (110999)
  • Neurology and Neuromuscular Diseases (110904)
  • Signal Transduction (060111)
  • Neurocognitive Patterns and Neural Networks (170205)

Research Objectives

  • Nervous System and Disorders (920111)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Expanding Knowledge in the Biological Sciences (970106)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Expanding Knowledge in Psychology and Cognitive Sciences (970117)
  • Health (929999)

Publications

Total publications

12

Journal Article

(12 outputs)
YearCitationAltmetrics
2019Cullen CL, Senesi M, Tang AD, Clutterbuck MT, Auderset L, et al., 'Low-intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain', Glia pp. 1-16. ISSN 0894-1491 (2019) [Refereed Article]

DOI: 10.1002/glia.23620 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Senesi M; Clutterbuck MT; O'Rourke ME; Young KM

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2019Lucia D, Burgess D, Cullen CL, Dorey ES, Rawashdeh O, et al., 'Periconceptional maternal alcohol consumption leads to behavioural changes in adult and aged offspring and alters the expression of hippocampal genes associated with learning and memory and regulators of the epigenome', Behavioural Brain Research, 362 pp. 249-257. ISSN 0166-4328 (2019) [Refereed Article]

DOI: 10.1016/j.bbr.2019.01.009 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2018Dorey ES, Cullen CL, Lucia D, Mah KM, Manchadi M-LR, et al., 'The impact of periconceptional alcohol exposure on fat preference and gene expression in the mesolimbic reward pathway in adult rat offspring', Journal of Developmental Origins of Health and Disease, 9, (2) pp. 223-231. ISSN 2040-1744 (2018) [Refereed Article]

DOI: 10.1017/S2040174417000824 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

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2018Pepper RE, Pitman KA, Cullen CL, Young KM, 'How do cells of the oligodendrocyte lineage affect neuronal circuits to influence motor function, memory and mood?', Frontiers in Cellular Neuroscience, 12 Article 399. ISSN 1662-5102 (2018) [Refereed Article]

DOI: 10.3389/fncel.2018.00399 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Pepper RE; Pitman KA; Young KM

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2017Cullen CL, Young KM, 'Can thyroid hormone analogues be used to overcome hypomyelination and demyelination of the central nervous system?', EBioMedicine, 26 pp. 15-16. ISSN 2352-3964 (2017) [Contribution to Refereed Journal]

DOI: 10.1016/j.ebiom.2017.11.004 [eCite] [Details]

Co-authors: Young KM

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2017Schlegel RN, Spiers JG, Moritz KM, Cullen CL, Bjorkman ST, et al., 'Maternal hypomagnesemia alters hippocampal NMDAR subunit expression and programs anxiety-like behaviour in adult offspring', Behavioural Brain Research, 328 pp. 39-47. ISSN 0166-4328 (2017) [Refereed Article]

DOI: 10.1016/j.bbr.2017.04.009 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

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2016Auderset L, Cullen CL, Young KM, 'Low density lipoprotein-receptor related protein 1 is differentially expressed by neuronal and glial populations in the developing and mature mouse central nervous system', PLoS One, 11, (6) Article e0155878. ISSN 1932-6203 (2016) [Refereed Article]

DOI: 10.1371/journal.pone.0155878 [eCite] [Details]

Citations: Scopus - 12Web of Science - 11

Co-authors: Auderset L; Young KM

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2016Cullen CL, Young KM, 'How does transcranial magnetic stimulation influence glial cells in the central nervous system?', Frontiers in Neural Circuits, 10 Article 26. ISSN 1662-5110 (2016) [Refereed Article]

DOI: 10.3389/fncir.2016.00026 [eCite] [Details]

Citations: Scopus - 22Web of Science - 23

Co-authors: Young KM

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2016O'Rourke ME, Cullen CL, Auderset L, Pitman KA, Achatz D, et al., 'Evaluating Tissue-Specific Recombination in a Pdgfrα-CreERT2 Transgenic Mouse Line', PLoS One, 11, (9) Article e0162858. ISSN 1932-6203 (2016) [Refereed Article]

DOI: 10.1371/journal.pone.0162858 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: O'Rourke ME; Pitman KA; Achatz D; Young KM

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2016Wang S, Bolos M, Clark R, Cullen CL, Southam KA, et al., 'Amyloid β precursor protein regulates neuron survival and maturation in the adult mouse brain', Molecular and Cellular Neurosciences, 77 pp. 21-33. ISSN 1044-7431 (2016) [Refereed Article]

DOI: 10.1016/j.mcn.2016.09.002 [eCite] [Details]

Citations: Scopus - 10Web of Science - 10

Co-authors: Wang S; Bolos M; Clark R; Southam KA; Foa L; Dickson TC; Young KM

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2014Cullen CL, Burne THJ, Lavidis NA, Moritz KM, 'Low dose prenatal alcohol exposure does not impair spatial learning and memory in two tests in adult and aged rats', PL o S One, 9, (6) Article e101482. ISSN 1932-6203 (2014) [Refereed Article]

DOI: 10.1371/journal.pone.0101482 [eCite] [Details]

Citations: Scopus - 12Web of Science - 12

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2013Cullen CL, Burne THJ, Lavidis NA, Moritz KM, 'Low Dose Prenatal Ethanol Exposure Induces Anxiety-Like Behaviour and Alters Dendritic Morphology in the Basolateral Amygdala of Rat Offspring', PL o S One, 8, (1) Article e54924. ISSN 1932-6203 (2013) [Refereed Article]

DOI: 10.1371/journal.pone.0054924 [eCite] [Details]

Citations: Scopus - 53Web of Science - 50

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Grants & Funding

Funding Summary

Number of grants

9

Total funding

$1,217,234

Projects

Clinical safety assessment of rTMS application for the treatment of MS (2019)$16,000
Description
Oligodendrocytes are brain cells that die in MS, but non-invasive brain stimulation (rTMS) can promote their generation in preclinical models of disease. This project will take an important role in the clinical translation of this treatment and determine whether this type of stimulation can be safely delivered to people with MS.
Funding
Royal Hobart Hospital Research Foundation ($16,000)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Cullen CL; Young Kaylene; Taylor BVM; Hinder MR
Year
2019
Can cognitive training promote remyelination (2018)$25,000
Description
Our research aims to identify physiological stimuli that can promote oligodendrocyte addition and augment the repair of lost or damaged myelin in the brain. We hope to provide vital proof of concept data demonstrating that different types of cognitive training can enhance oligodendrocyte production in the brain, and that through this process can expedite myelin repair within a demyelinated lesion.
Funding
Multiple Sclerosis Research Australia ($25,000)
Scheme
Grant-Incubator
Administered By
University of Tasmania
Research Team
Cullen CL
Year
2018
Investigating ferroptosis as a novel mechanism of oligodendrocyte death. (2018)$30,000
Description
This project aims to understand the mode of cell death induced by a stroke, and determine the capacity for already developed therapeutics to rescue these cells. By saving oligodendrocytes from death after stroke, we aim to reduce the lesion size, but also keep these critical cells in place to support nerve cell survival and function.
Funding
Brain Foundation ($30,000)
Scheme
Grant-Research
Administered By
University of Tasmania
Research Team
Cullen CL; Young Kaylene; Sutherland BA
Year
2018
The pathological effects of Alzheimer's disease on axons (2018 - 2020)$90,000
Description
Proposed PhD project investigating the role of amyoloid upon axonal dystrophies in the progression of Alzheimers disease
Funding
Dementia Australia Research Foundation Ltd ($90,000)
Scheme
Grant-Scholarship
Administered By
University of Tasmania
Research Team
Young Kaylene; Blizzard C; Cullen CL; Sutherland BA
Period
2018 - 2020
Using non-invasive magnetic stimulation to promote remyelination (2018 - 2020)$664,868
Description
In patients with multiple sclerosis, brain insulation is lost from nerves. This leads to permanent and progressive disability. We have identified a non-invasive method of magnetic stimulation, and have shown that it increases the number of new insulating cells naturally added to the brain. In this study we will determine the extent to which our new treatment can induce insulation replacement to nerves in models of multiple sclerosis.
Funding
National Health & Medical Research Council ($664,868)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Young Kaylene; Rodger Jennifer; Cullen CL
Period
2018 - 2020
Grant Reference
1139041
Enhancing activity to drive myelin repair in preclinical models of multiple sclerosis (2017 - 2019)$170,000
Description
This project examines the ability of repetitive transcranial magnetic stimulation to promote remyelination in two preclinical models of multiple sclerosis.
Funding
Multiple Sclerosis Research Australia ($170,000)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Young Kaylene; Cullen CL; Rodger Jennifer
Period
2017 - 2019
Preclinical trial of rTMS in Multiple Sclerosis (2016 - 2018)$207,000
Description
This project will contribute new knowledge about the role of oligodendrocyte in MS pathogenesis and the importance of oligodendrocyte progenitor cells as a therapeutic target in the treatment of MS
Funding
Multiple Sclerosis Research Australia ($207,000)
Scheme
Fellowship-Postdoctoral
Administered By
University of Tasmania
Research Team
Cullen CL; Young Kaylene
Period
2016 - 2018
non-invasively promote myelination in vivo (2015)$12,866
Funding
University of Tasmania ($12,866)
Scheme
Grant-Research Enhancement (REGS)
Administered By
University of Tasmania
Research Team
Cullen CL
Year
2015
2015 International Society of Neurochemistry, Myelin Satellite Meeting (2015)$1,500
Funding
University of Tasmania ($1,500)
Scheme
Grant-Conference Support Scheme
Administered By
University of Tasmania
Research Team
Cullen CL
Year
2015

Research Supervision

Current

4

Completed

1

Current

DegreeTitleCommenced
PhDInvestigating the role of oligodendrocyte cells in mediating dementia-related demyelination2015
PhDThe Cells of the Oligodendrocyte Lineage are Differentially Altered by MAPT Accumulation and Amyloidosis2015
PhDDoes Myelination Contribute to Learned Fear and Post-Traumatic Stress Disorder?2016
PhDHow Do Myelinating Cells Alter Brain Circuits to Facilitate Learning?2018

Completed

DegreeTitleCompleted
PhDConditionally and Acutely Ablating Kif3a from Oligodendrocyte Progenitor Cells Impairs Primary Cilum Assembly and Cell Function
Candidate: Megan Elizabeth O'Rourke
2018