Profiles

Feng Pan

UTAS Home Dr Feng Pan

Feng Pan

Senior Research Fellow

Room 354-04, Level 3 , MS2

+61 420455798 (phone)

+61 3 62267704 (fax)

Feng.Pan@utas.edu.au

Dr Feng Pan is a Senior Research Fellow at the Menzies Institute for Medical Research, supported by the NHMRC Early Career Fellowship. His research interests span both epidemiology and clinical interventions to osteoarthritis-related pain. Much of his work has been on identifying biomechanical risk factors for chronic pain and osteoarthritis, identifying pain and osteoarthritis phenotypes and testing new therapeutic treatments.

Biography

Dr Pan completed a Masters of Medical Oncology in 2012, having completed a Bachelor of Medicine in 2009. His PhD was conferred in May 2017. His thesis work assessed the genetic and systemic factors in knee osteoarthritis and pain. Prior to his PhD, Dr Pan worked as an oncologist at the Anhui Provincial Hospital affiliated with University of Science and Technology of China.

Career summary

Qualifications

  • PhD, University of Tasmania, Australia, 2017. Thesis: Genetic and systemic factors in knee osteoarthritis and its symptoms
  • MMed (Oncology), Anhui Medical University, China, 2012
  • MBBS, Anhui Medical University, China, 2009

Languages (other than English)

Mandarin

Memberships

Professional practice

  • Osteoarthritis Research Society International;
  • International Association for the Study of Pain;
  • American Society for Bone and Mineral Research;
  • American Society of Clinical Oncology;
  • Australian Pain Society;
  • Australian Association of Gerontology;
  • Australasian Epidemiological Association;
  • Australian & New Zealand Bone and Mineral Society;
  • Australia & New Zealand Musculoskeletal Clinical Trials Network;
  • International Epidemiological Association;

Administrative expertise

  • Cohort study and clinical trials’ project management
  • Journal Club and Data Presentation Coordinator, Menzies Institute for Medical Research
  • Invitations to review manuscripts for 38 peer-reviewed international journals
  • Abstract reviewer for conferences (e.g. 2020 World Congress of Epidemiology, 2017 World Congress on Public Health; 2018 Australia Public Health Conference and 2017, 2018, 2019 and 2020 Australian Society for Medical Research (ASMR) research week)
  • Grant reviewer for the NHMRC project and Health Research Board, Ireland
  • Committee member:
    • International Association for the Study of Pain (IASP), Musculoskeletal pain: general officer;
    • American Society of Clinical Oncology International Member Liaisons Group;
    • Australian and New Zealand Bone and Mineral Society (ANZBMS) Newsletter Editorial Board Member;
    • Australasian Epidemiological Association (AEA) Tasmanian Chapter: convenors;
    • Australian Association of Gerontology (AAG) Tasmania division;

Research Appointments

  • Editorial Board: Pain and Therapy (2020- Current)
  • Associate Editor: Frontiers in Medicine (2019-Current); BMC Musculoskeletal Disorders (2018-Current); BMC Public Health (2019-Current); BMC Health Services Research (2019-Current)
  • Academic Editor: PLOS ONE (2018-Current)
  • Reviewer Board: Metabolites (2020-Current)

Research Invitations

Dr Pan has presented his work as first-author at 36 international conferences in the last 5 years, including 16 orals at the most prestigious conferences in Rheumatology (e.g. 3 orals at American College of Rheumatology (ACR) Annual Conference, 7 orals at Annual European Congress of Rheumatology (EULAR), 1 oral at World Congress on Osteoarthritis, 1 oral at Annual Congress of Bone, Muscle & Joint Diseases (BMJD), and 1 oral at 7th Asia-Pacific Osteoporosis Conference). He was also keynote speaker at Australian Pain Society 41st Annual Scientific Meeting. Noteworthy conferences with oral presentations include:

  • Sleep disturbance and its association with pain severity and distribution: a prospective 10.7-year study. Australian Pain Society 41st Annual Scientific Meeting. Canberra, Australia, 18th – 21st April 2021.
  • Muscle function and power but not mass protect against more severe knee pain trajectories. Australian Pain Society 40th Annual Scientific Meeting. Hobart, Australia, 5th–8th Apr 2020.
  • Do distinct pain phenotypes have difference risk of knee replacement: a 13.7-year follow-up study? Annual European Congress of Rheumatology (EULAR). Madrid, Spain, 12th–15th Jun 2019.
  • Association between metabolic syndrome and knee structural change on MRI: a 10.7-year follow-up study. Annual European Congress of Rheumatology (EULAR). Madrid, Spain, 12th–15th Jun 2019. Pain at multiple sites associates with prevalence and incidence of fractures in older adults: a 5.1-year follow-up study. 7th Asia-Pacific Osteoporosis Conference. Sydney, Australia, 28th Nov–1st Dec 2018.
  • Association between metabolic syndrome and trajectories of knee pain: a 10.7-year follow-up study. Annual European Congress of Rheumatology (EULAR). Amsterdam, Netherlands, 13th–16th Jun 2018.
  • Non-conventional role of pain at other sites for association between knee structural pathology and knee pain and cartilage loss. World Congress on Controversies, Debates & Consensus in Bone, Muscle & Joint Diseases (BMJD). Gold Coast, Australia, 31st Aug–3rd Sep 2017.
  • Predictors and MRI-detected structural pathology with trajectories of knee pain severity: a 10.7-year prospective study. Annual European Congress of Rheumatology (EULAR). Madrid, Spain, 14th–17th Jun 2017.
  • Differentiating pain phenotypes in knee osteoarthritis: a 10-year prospective study. World Congress on Osteoarthritis. Las Vegas, US, 27th-30th Apr 2017.
  • Which Factors Associate with Localized Knee Pain and Generalized Pain: A 10-Year Longitudinal Study? American College of Rheumatology (ACR) Annual Conference. Washington, DC, US, 11th–16th Nov 2016.
  • Does “pain elsewhere” influence the association between knee structural pathology and knee pain? Annual European Congress of Rheumatology (EULAR). London, UK, 8th–11th Jun 2016.
  • Genetic effects on trabecular and cortical volumetric bone mineral densities and bone microstructure measured by HRpQCT. Annual European Congress of Rheumatology (EULAR). London, UK, 8th–11th Jun 2016.
  • Which factors explain multi-site pain caused by obesity: a 5-year follow-up study in older adults? American College of Rheumatology (ACR) Annual Conference. San Francisco, US, 6th–11th Nov 2015.
  • Pain at multiple sites outside the knee predicts knee cartilage volume loss: a prospective study in older adults. Annual European Congress of Rheumatology (EULAR). Rome, Italy, 10th–13th Jun 2015.
  • Does a Family History of Total Knee Replacement for Knee Osteoarthritis Influence Knee Pain and Structural Progression? a Prospective Longitudinal Cohort Study. American College of Rheumatology (ACR) Annual Conference. Boston, US, 14th–19th Nov 2014.

View more on Dr Feng Pan in WARP

Expertise

  • Clinical trials in chronic diseases
  • Chronic pain assessment and management
  • Data management of observational studies
  • Complex health data analysis
  • Systematic literature review and meta-analysis

Research Themes

Feng’s research aligns to the University’s research theme of Better Health. His research interests include understanding the role of biomechanical risk factors in osteoarthritis and chronic pain and developing optimal management and treatment strategies.

His current research tackles the urgent unmet need for effective management strategies for osteoarthritis by identifying osteoarthritis phenotypes, understanding of distinct mechanisms underlying different phenotypes and developing novel and tailored treatments towards improved patient stratification. He is currently leading four projects to identify pain phenotypes and their long-term health outcomes adults and evaluate the effect of an agent in knee osteoarthritis pain patients.

Collaboration

Dr Pan is currently involved in two international projects which primarily examines the risk factors and prognostic factors of pain phenotypes, and understand underlying mechanisms of different phenotypes.

Awards

Dr Pan has received yearly awards/prizes in recognition of the novelty and significance of his research since commencing his PhD. The most prestigious awards/prizes include:

  • 2021 Australian Pain Society ‘Rising Star Award’
  • 2020 and 2015 ‘Ten of the best’ award, Menzies Institute for Medical Research
  • 2020, 2019, 2018, 2017, 2016 and 2015 EULAR travel bursaries
  • 2019, 2018 and 2017 ESCEO-Eli Lilly Scholarship
  • 2019 Tasmania STEM (Science, Technology, Engineering and Mathematics) Young Researcher of the Year Award Finalist
  • 2019 University of Tasmania, College of Health and Medicine, Early Career Researcher Award
  • 2019 and 2018 International Federation of Musculoskeletal Research Societies (IFMRS) Travel Award
  • 2019 Australian and New Zealand Bone and Mineral Society (ANZBMS) Travel Award
  • 2018 International Osteoporosis Foundation (IOF) Young Investigator Award
  • 2018 Royal Society of Tasmania Annual Doctoral Awards
  • 2018 Osteoarthritis Research Society International (OARSI) Scholarship
  • 2017 Bone, Muscle & Joint Diseases (BMJD) Young Scientist Award
  • 2016 Chinese Government Award for Outstanding Self-Financed Students Abroad
  • 2015 Australasian Epidemiological Association (AEA) Conference Award
  • 2014 Graduate Research Travel and Conference Fund Grant, University of Tasmania

Current projects

  • Osteoarthritis pain phenotype and its predictive value
  • Pain trajectories and their underlying mechanisms
  • Clinical utility of multi-site pain and its mechanisms
  • Determinants of progressive early structural damage on MRI
  • Metabolomics in osteoarthritis and its symptoms
  • Developing effective treatments for patients with a specific pain/structural phenotype

Fields of Research

  • Rheumatology and arthritis (320223)
  • Cancer cell biology (321101)
  • Epidemiology (420299)
  • Pain (320218)
  • Endocrinology (320208)
  • Aged health care (420301)
  • Primary health care (420319)
  • Gastroenterology and hepatology (320209)
  • Sports medicine (320225)
  • Orthopaedics (320216)
  • Medical biochemistry - lipids (320504)

Research Objectives

  • Clinical health (200199)
  • Evaluation of health outcomes (200202)
  • Human pain management (200103)
  • Health related to ageing (200502)
  • Prevention of human diseases and conditions (200104)
  • Adolescent health (200501)
  • Mental health (200409)
  • Preventive medicine (200412)
  • Diagnosis of human diseases and conditions (200101)
  • Treatment of human diseases and conditions (200105)

Publications

Despite the early stage of his career, he has 43 publications (32 as first or co-first author, 22 in the top specialist journals), including Annals of the Rheumatic Diseases (the highest ranked rheumatology journal internationally for original research), Osteoarthritis Cartilage (second highest ranked journal in Orthopaedics), Journal of Bone and Mineral Research (highest ranked bone journal), and PAIN journal (top journal in pain field).

Total publications

44

Journal Article

(38 outputs)
YearCitationAltmetrics
2021Pan F, Owen N, Oddy WH, 'Sugar sweetened beverages and increasing prevalence of type 2 diabetes in the Indigenous community of Australia', Nutrition, Metabolism & Cardiovascular Diseases ISSN 0939-4753 (2021) [Refereed Article]

DOI: 10.1016/j.numecd.2021.06.014 [eCite] [Details]

Co-authors: Oddy WH

Tweet

2021Pan F, Tian J, Cicuttini F, Jones G, 'Sleep disturbance and bone mineral density, risk of falls and fracture: Results from a 10.7-year prospective cohort study', Bone, 147 pp. 1-6. ISSN 1873-2763 (2021) [Refereed Article]

DOI: 10.1016/j.bone.2021.115938 [eCite] [Details]

Co-authors: Tian J; Jones G

Tweet

2021Pan F, Tian J, Scott D, Cicuttini F, Jones G, 'Muscle function, quality and relative mass are associated with knee pain trajectory over 10.7 years', Pain ISSN 0304-3959 (2021) [Refereed Article]

DOI: 10.1097/j.pain.0000000000002383 [eCite] [Details]

Co-authors: Tian J; Scott D; Jones G

Tweet

2021Pan T-T, Pan F, Gao W, Hu S-s, Wang D, 'Involvement of macrophages and spinal microglia in osteoarthritis pain', Current Rheumatology Reports, 23, (5) pp. 1-7. ISSN 1523-3774 (2021) [Refereed Article]

DOI: 10.1007/s11926-021-00997-w [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Tweet

2020Ma C, Pan F, Yang Y, Laslett L, Squibb K, et al., 'Distal radius bone microarchitecture: what are the differences between age 25 and old age?', Archives of Osteoporosis, 15, (1) Article 16. ISSN 1862-3522 (2020) [Refereed Article]

DOI: 10.1007/s11657-020-0696-9 [eCite] [Details]

Co-authors: Ma C; Laslett L; Squibb K; Winzenberg T; Jones G

Tweet

2020Ma C, Wu F, Pan F, Laslett L, Shah A, et al., 'Bone microarchitecture, volumetric or areal bone mineral density for discrimination of vertebral deformity in adults: a cross-sectional study', Journal of Clinical Densitometry pp. 1-10. ISSN 1094-6950 (2020) [Refereed Article]

DOI: 10.1016/j.jocd.2020.05.005 [eCite] [Details]

Co-authors: Ma C; Wu F; Laslett L; Shah A; Squibb K; Winzenberg T; Jones G

Tweet

2020Munugoda IP, Pan F, Wills K, Mattap SM, Cicuttini F, et al., 'Identifying subgroups of community-dwelling older adults and their prospective associations with long-term knee osteoarthritis outcomes', Clinical Rheumatology, 39, (5) pp. 1429-1437. ISSN 0770-3198 (2020) [Refereed Article]

DOI: 10.1007/s10067-019-04920-8 [eCite] [Details]

Co-authors: Munugoda IP; Wills K; Mattap SM; Jones G; Callisaya ML; Aitken D

Tweet

2020Pan F, Liu M, Randell EW, Rahman P, Jones G, et al., 'Sphingomyelin is involved in multisite musculoskeletal pain: evidence from metabolomic analysis in two independent cohorts', Pain pp. 1-6. ISSN 0304-3959 (2020) [Refereed Article]

DOI: 10.1097/j.pain.0000000000002163 [eCite] [Details]

Co-authors: Jones G

Tweet

2020Pan F, Tian J, Cicuttini F, Jones G, 'Metabolic syndrome and trajectory of knee pain in older adults', Osteoarthritis and Cartilage, 28, (1) pp. 45-52. ISSN 1063-4584 (2020) [Refereed Article]

DOI: 10.1016/j.joca.2019.05.030 [eCite] [Details]

Citations: Scopus - 2Web of Science - 1

Co-authors: Tian J; Jones G

Tweet

2020Pan F, Tian J, Cicuttini F, Jones G, 'Sleep disturbance and its association with pain severity and multisite pain: a prospective 10.7-Year study', Pain and Therapy, 9, (2) pp. 751-763. ISSN 2193-8237 (2020) [Refereed Article]

DOI: 10.1007/s40122-020-00208-x [eCite] [Details]

Citations: Web of Science - 2

Co-authors: Tian J; Jones G

Tweet

2020Pan F, Tian J, Mattap SM, Cicuttini F, Jones G, 'Association between metabolic syndrome and knee structural change on MRI', Rheumatology, 59, (1) pp. 185-193. ISSN 1462-0324 (2020) [Refereed Article]

DOI: 10.1093/rheumatology/kez266 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Tian J; Mattap SM; Jones G

Tweet

2020Pan F, Tian J, Munugoda IP, Graves S, Lorimer M, et al., 'Do knee pain phenotypes have different risks of total knee replacement?', Journal of Clinical Medicine, 9, (3) Article 632. ISSN 2077-0383 (2020) [Refereed Article]

DOI: 10.3390/jcm9030632 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Tian J; Munugoda IP; Jones G

Tweet

2020Wan F, Pan F, Ayonrinde OT, Adams LA, Mori TA, et al., 'Validation of fatty liver disease scoring systems for ultrasound diagnosed non-alcoholic fatty liver disease in adolescents', Digestive and Liver Disease pp. 1-7. ISSN 1590-8658 (2020) [Refereed Article]

DOI: 10.1016/j.dld.2020.11.037 [eCite] [Details]

Citations: Web of Science - 5

Co-authors: Oddy WH

Tweet

2019Mattap SM, Laslett LL, Squibb K, Wills K, Otahal P, et al., 'Hand examination, ultrasound and its association with hand pain and function in community-based older adults', Arthritis Care & Research pp. 1-28. ISSN 2151-464X (2019) [Refereed Article]

DOI: 10.1002/acr.24128 [eCite] [Details]

Co-authors: Mattap SM; Laslett LL; Squibb K; Wills K; Otahal P; Aitken D; Winzenberg T; Jones G

Tweet

2019Pan F, Tian J, Aitken D, Cicuttini F, Jones G, 'Pain at multiple sites is associated with prevalent and incident fractures in older adults', Journal of Bone and Mineral Research, 34, (11) pp. 2012-2018. ISSN 0884-0431 (2019) [Refereed Article]

DOI: 10.1002/jbmr.3817 [eCite] [Details]

Citations: Scopus - 1Web of Science - 2

Co-authors: Tian J; Aitken D; Jones G

Tweet

2019Yang Y, Wu F, Antony B, Pan F, Winzenberg T, et al., 'The association between first fractures sustained during childhood and adulthood and bone measures in young adulthood', Journal of Pediatrics, 212 pp. 188-194. ISSN 0022-3476 (2019) [Refereed Article]

DOI: 10.1016/j.jpeds.2019.05.031 [eCite] [Details]

Citations: Scopus - 1Web of Science - 3

Co-authors: Wu F; Antony B; Winzenberg T; Jones G

Tweet

2018Aitken D, Laslett LL, Pan F, Haugen IK, Otahal P, et al., 'A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis - the HUMOR trial', Osteoarthritis and Cartilage, 26, (7) pp. 880-887. ISSN 1063-4584 (2018) [Refereed Article]

DOI: 10.1016/j.joca.2018.02.899 [eCite] [Details]

Citations: Scopus - 39Web of Science - 5

Co-authors: Aitken D; Laslett LL; Otahal P; Jones G

Tweet

2018Cai G, Laslett LL, Aitken D, Halliday A, Pan F, et al., 'Effect of Zoledronic Acid and Denosumab in patients with low back pain and modic change: A proof-of-principle trial', Journal of Bone and Mineral Research, 33, (5) pp. 773-782. ISSN 0884-0431 (2018) [Refereed Article]

DOI: 10.1002/jbmr.3376 [eCite] [Details]

Citations: Scopus - 16

Co-authors: Laslett LL; Aitken D; Otahal P; Winzenberg TM; Jones G

Tweet

2018Laslett LL, Menz HB, Otahal P, Pan F, Cicuttini FM, et al., 'Factors associated with prevalent and incident foot pain: data from the Tasmanian Older Adult Cohort Study', Maturitas, 118 pp. 38-43. ISSN 0378-5122 (2018) [Refereed Article]

DOI: 10.1016/j.maturitas.2018.10.004 [eCite] [Details]

Citations: Scopus - 3Web of Science - 2

Co-authors: Laslett LL; Otahal P; Jones G

Tweet

2018Oddy WH, Allen KL, Trapp GSA, Ambrosini GL, Black LJ, et al., 'Dietary patterns, body mass index and inflammation: Pathways to depression and mental health problems in adolescents', Brain, Behavior, and Immunity, 69 pp. 428-439. ISSN 0889-1591 (2018) [Refereed Article]

DOI: 10.1016/j.bbi.2018.01.002 [eCite] [Details]

Citations: Scopus - 49Web of Science - 44

Co-authors: Oddy WH

Tweet

2018Pan F, Byrne KS, Ramakrishnan R, Ferreira M, Dwyer T, et al., 'Association between musculoskeletal pain at multiple sites and objectively measured physical activity and work capacity: Results from UK Biobank study', Journal of Science and Medicine in Sport pp. 1-6. ISSN 1440-2440 (2018) [Refereed Article]

DOI: 10.1016/j.jsams.2018.10.008 [eCite] [Details]

Citations: Scopus - 9

Co-authors: Dwyer T; Jones G

Tweet

2018Pan F, Jones G, 'Clinical perspective on pain and pain phenotypes in osteoarthritis', Current Rheumatology Reports, 20, (12) Article 79. ISSN 1534-6307 (2018) [Refereed Article]

DOI: 10.1007/s11926-018-0796-3 [eCite] [Details]

Citations: Scopus - 10Web of Science - 9

Co-authors: Jones G

Tweet

2018Pan F, Tian J, Aitken D, Cicuttini F, Jones G, 'Predictors of pain severity trajectory in older adults: a 10.7-year follow-up study', Osteoarthritis and Cartilage, 26, (12) pp. 1619-1626. ISSN 1063-4584 (2018) [Refereed Article]

DOI: 10.1016/j.joca.2018.08.002 [eCite] [Details]

Citations: Scopus - 14Web of Science - 5

Co-authors: Tian J; Aitken D; Jones G

Tweet

2018Pan F, Tian J, Cicuttini F, Jones G, Aitken D, 'Differentiating knee pain phenotypes in older adults: a prospective cohort study', Rheumatology, 58, (2) pp. 274-283. ISSN 1462-0324 (2018) [Refereed Article]

DOI: 10.1093/rheumatology/key299 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Tian J; Jones G; Aitken D

Tweet

2018Yang Y, Pan F, Wu F, Squibb K, Thomson R, et al., 'Familial resemblance in trabecular and cortical volumetric bone mineral density and bone microarchitecture as measured by HRpQCT', Bone, 110 pp. 76-83. ISSN 8756-3282 (2018) [Refereed Article]

DOI: 10.1016/j.bone.2018.01.033 [eCite] [Details]

Citations: Scopus - 9Web of Science - 8

Co-authors: Yang Y; Wu F; Squibb K; Winzenberg T; Jones G

Tweet

2017Pan F, Blizzard L, Tian J, Cicuttini F, Winzenberg T, et al., 'The interaction between weight and family history of total knee replacement with knee cartilage: a 10-year prospective study', Osteoarthritis and Cartilage, 25, (2) pp. 227-233. ISSN 1063-4584 (2017) [Refereed Article]

DOI: 10.1016/j.joca.2016.10.013 [eCite] [Details]

Citations: Scopus - 3Web of Science - 2

Co-authors: Blizzard L; Tian J; Winzenberg T; Ding C; Jones G

Tweet

2017Pan F, Laslett L, Blizzard L, Cicuttini F, Winzenberg T, et al., 'Associations between fat mass and multi-site pain: A 5-year longitudinal study', Arthritis Care & Research, 69, (4) pp. 509-516. ISSN 2151-464X (2017) [Refereed Article]

DOI: 10.1002/acr.22963 [eCite] [Details]

Citations: Scopus - 16Web of Science - 18

Co-authors: Laslett L; Blizzard L; Winzenberg T; Ding C; Jones G

Tweet

2017Pan F, Laslett L, Tian J, Cicuttini F, Winzenberg T, et al., 'Association Between Pain at Sites Outside the Knee and Knee Cartilage Volume Loss in Elderly People Without Knee Osteoarthritis: A Prospective Study', Arthritis Care & Research, 69, (5) pp. 659-666. ISSN 2151-464X (2017) [Refereed Article]

DOI: 10.1002/acr.22964 [eCite] [Details]

Citations: Scopus - 4Web of Science - 5

Co-authors: Laslett L; Tian J; Winzenberg T; Ding C; Jones G

Tweet

2017Pan F, Tian J, Aitken D, Cicuttini F, Winzenberg T, et al., 'The association of knee structural pathology with pain at the knee is modified by pain at other sites in those with knee osteoarthritis', Clinical Rheumatology, 36, (11) pp. 2549-2555. ISSN 0770-3198 (2017) [Refereed Article]

DOI: 10.1007/s10067-017-3838-8 [eCite] [Details]

Citations: Scopus - 1Web of Science - 2

Co-authors: Tian J; Aitken D; Winzenberg T; Jones G

Tweet

2017Zhu Z, Laslett LL, Han W, Antony B, Pan F, et al., 'Associations between MRI-detected early osteophytes and knee structure in older adults: a population-based cohort study', Osteoarthritis and Cartilage, 25, (12) pp. 2055-2062. ISSN 1063-4584 (2017) [Refereed Article]

DOI: 10.1016/j.joca.2017.09.005 [eCite] [Details]

Citations: Scopus - 6Web of Science - 5

Co-authors: Zhu Z; Laslett LL; Han W; Antony B; Jones G; Ding C

Tweet

2016Pan F, Ding C, Winzenberg T, Khan H, Martel-Pelletier J, et al., 'The offspring of people with a total knee replacement for severe primary knee osteoarthritis have a higher risk of worsening knee pain over 8 years', ARD Online, 75, (2) pp. 368-373. ISSN 1468-2060 (2016) [Refereed Article]

DOI: 10.1136/annrheumdis-2014-206005 [eCite] [Details]

Citations: Scopus - 10Web of Science - 9

Co-authors: Ding C; Winzenberg T; Khan H; Jones G

Tweet

2015Pan Feng, Khan K, Ding C, Winzenberg T, Martel-Pelletier J, et al., 'Familial effects on structural changes relevant to knee osteoarthritis: a prospective cohort study', Osteoarthritis and Cartilage, 23, (1) pp. 559-564. ISSN 1063-4584 (2015) [Refereed Article]

DOI: 10.1016/j.joca.2015.01.004 [eCite] [Details]

Citations: Scopus - 5Web of Science - 4

Co-authors: Khan K; Ding C; Winzenberg T; Jones G

Tweet

2014Pan F, Tian J, Winzenberg T, Ding C, Jones G, 'Association between GDF5 rs143383 polymorphism and knee osteoarthritis: an updated meta-analysis based on 23,995 subjects', BMC Musculoskeletal Disorders, 15, (1) Article 404. ISSN 1471-2474 (2014) [Refereed Article]

DOI: 10.1186/1471-2474-15-404 [eCite] [Details]

Citations: Scopus - 20Web of Science - 18

Co-authors: Tian J; Winzenberg T; Ding C; Jones G

Tweet

2012Pan F, Tian J, Ji CS, He YF, Han XH, et al., 'Association of TNF-α-308 and -238 polymorphisms with risk of cervical cancer: a meta-analysis', Asian Pacific Journal of Cancer Prevention, 13, (11) pp. 5777-5783. ISSN 1513-7368 (2012) [Refereed Article]

DOI: 10.7314/APJCP.2012.13.11.5777 [eCite] [Details]

Citations: Scopus - 26Web of Science - 23

Co-authors: Tian J

Tweet

2012Pan F, Tian J, Pan Y-Y, Zhang Y, 'Association of IL-10-1082 promoter polymorphism with susceptibility to gastric cancer: evidence from 22 case-control studies', Molecular Biology Reports, 39, (6) pp. 7143-7154. ISSN 0301-4851 (2012) [Refereed Article]

DOI: 10.1007/s11033-012-1546-7 [eCite] [Details]

Citations: Scopus - 19Web of Science - 18

Tweet

2012Tian J, Pan F, Li J, Ma Y, Cen H, et al., 'Association between the FAS/FASL polymorphisms and gastric cancer risk: a meta-analysis', Asian Pacific Journal of Cancer Prevention, 13, (3) pp. 945-951. ISSN 1513-7368 (2012) [Refereed Article]

DOI: 10.7314/apjcp.2012.13.3.945 [eCite] [Details]

Citations: Scopus - 12Web of Science - 10

Tweet

2011Pan F, Tian J, Pan Y, Zhang Y, 'Lack of association of the cyclooxygenase 8473 T>C polymorphism with lung cancer: evidence from 9841 subjects', Asian Pacific Journal of Cancer Prevention, 12, (8) pp. 1941-1945. ISSN 1513-7368 (2011) [Refereed Article]

PMID: 22292629 [eCite] [Details]

Citations: Web of Science - 10

Tweet

2011Pan F, Tian J, Zhang X, Zhang Y, Pan Y, 'Synergistic interaction between sunitinib and docetaxel is sequence dependent in human non-small lung cancer with EGFR TKIs-resistant mutation', Journal of Cancer Research and Clinical Oncology, 137, (9) pp. 1397-1408. ISSN 0171-5216 (2011) [Refereed Article]

DOI: 10.1007/s00432-011-1009-x [eCite] [Details]

Citations: Scopus - 15Web of Science - 17

Tweet

Conference Publication

(6 outputs)
YearCitationAltmetrics
2018Pan F, Tian J, Aitken D, Cicuttini F, Jones G, 'Pain at multiple sites is associated with prevalent and incident fractures in older adults: a 5.1-year follow-up study', Journal of Bone and Mineral Research, ASBMR Annual Meeting 2018, September - October, Montreal, Canada ISSN 0884-0431 (2018) [Conference Extract]

[eCite] [Details]

Co-authors: Tian J; Aitken D; Jones G

2018Pan F, Tian J, Cicuttini F, Ding C, 'Determinants of trajectories of multi-site pain in knee osteoarthritis: a 10.7-year prospective study in older adults', Annals of the Rheumatic Diseases, Annual European Congress of Rheumatology, 13-16 June, Amsterdam, pp. 1195, Vol 77 (Suppl 2). ISSN 0003-4967 (2018) [Conference Extract]

DOI: 10.1136/annrheumdis-2018-eular.2505 [eCite] [Details]

Co-authors: Tian J; Ding C

Tweet

2018Pan F, Tian J, Cicuttini F, Ding C, Jones G, 'Association between metabolic syndrome and trajectories of knee pain: a 10.7 year follow-up study', Annals of the Rheumatic Diseases, pp. 214, June. ISSN 0003-4967 (2018) [Conference Extract]

DOI: 10.1136/annrheumdis-2018-eular.2501 [eCite] [Details]

Citations: Web of Science - 1

Co-authors: Tian J; Ding C; Jones G

Tweet

2017Pan F, Tian J, Aitken D, Cicuttini F, Ding C, et al., 'Characterizing and validating the phenotype of knee pain: a latent class analysis', Annals of the Rheumatic Diseases, pp. 471, June. ISSN 0003-4967 (2017) [Conference Extract]

DOI: 10.1136/annrheumdis-2017-eular.3033 [eCite] [Details]

Co-authors: Tian J; Aitken D; Ding C; Jones G

Tweet

2016Pan F, Aitken D, Tian J, Cicuttini FM, Ding C, et al., 'Which factors associate with localized knee pain and generalized pain: A 10-year longitudinal study?', Arthritis & Rheumatology, pp. 1, Vol 68, (suppl 10). ISSN 2326-5191 (2016) [Conference Extract]

[eCite] [Details]

Co-authors: Aitken D; Tian J; Ding C; Jones G

2016Pan F, Blizzard L, Tian J, Cicuttini F, Winzenberg T, et al., 'Does weight in the offspring of people with a total knee replacement for severe primary knee osteoarthritis have a more detrimental effect on knee cartilage and pain? A 10-year prospective study', Annals of the Rheumatic Diseases, pp. 825, June. ISSN 0003-4967 (2016) [Conference Extract]

DOI: 10.1136/annrheumdis-2016-eular.2592 [eCite] [Details]

Co-authors: Blizzard L; Tian J; Winzenberg T; Ding C; Jones G

Tweet

Grants & Funding

Dr Pan has secured funding as CIA from competitive sources totalling >$700,000, including Royal Hobart Hospital Research Foundation Incubator Grant ($9,750); 2020 Arthritis Australia Project Grant ($44,000); 2019 Menzies Philanthropic Grant ($30,000);  2019 NHMRC Early Career Fellowship ($327,192), 2018 Menzies Institute for Medical Research Development Grant ($23,267), 2018 University of Tasmania Research Enhancement Grant ($9,669), 2017 Arthritis Australia Heald Fellowship ($50,000) and 2016 Farrell Foundation Fellowship ($144,000).

Funding Summary

Number of grants

6

Total funding

$584,611

Projects

The relationship of sleep and pain trajectories: a role of inflammation mechanism (2021)$9,750
Description
Sleep problems are highly prevalent in patients with chronic pain conditions. Traditionally, it has been thought that the two conditions are related reciprocally in a bidirectional manner, yet the direction of causality as well as inflammation mechanism that may be involved in the modulation of pain by sleep problems have not been clear. Osteoarthritis (OA) is the most common cause of musculoskeletal pain and pain in OA is individualised and complex. Our recent studies have demonstrated that pain in OA consists of homogeneous subgroups following distinct pain trajectories. Our first hypothesis is that sleep-pain trajectories relationship is bidirectional in OA patients with higher risk of having worse pain trajectories in those with more severe sleep problems, but sleep problem is a stronger predictor of pain than pain of sleep problem. Previous studies have reported that sleep disturbance may lead to an elevated level of inflammatory marker, and inflammation may have an important role in pain. Based on this, our second exploratory hypothesis is that inflammation is a mediator in the relationship between sleep and pain. Using over 10-year follow-up data from the Tasmanian Older Adult Cohort (TASOAC) study, we aim to: 1) examine the association between sleep disturbance and pain trajectories and determine its direction of causality; 2) explore the inflammatory markers in the relationship between sleep disturbance and pain trajectories.
Funding
Royal Hobart Hospital Research Foundation ($9,750)
Scheme
Grant-Incubator
Administered By
University of Tasmania
Research Team
Pan Feng; Jones Graeme; Francis H
Year
2021
The role of systemic inflammation in osteoarthritis pain trajectories (2020)$44,000
Description
Pain experience in knee osteoarthritis (OA) is individualised and complex. Inflammation has been suggested a key role in the pathophysiology of osteoarthritis-related pain. Our recent studies demonstrate that pain in OA consists of homogeneous subgroups following distinct pain trajectories. Pilot data from a small sample found that inflammatory makers may be involved in the development and maintenance of worse pain trajectories. Therefore, this project aims to expand our biomarker testing to a large sample in a convenient cohort study, thereby determining the role of inflammation in the development and maintenance of pain trajectories. This study will facilitate our understanding of underlying mechanisms of each of pain trajectories, and thus allows for early tailored interventions to shift pain trajectory to a favour course.
Funding
Arthritis Australia ($44,000)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Pan Feng; Jones Graeme
Year
2020
Improving Outcomes in Osteoarthritis: Developing Tailored Treatments to Specific Subsets of Patients with Osteoarthritis (2019 - 2022)$327,192
Funding
National Health & Medical Research Council ($327,192)
Scheme
Fellowship-Early Career
Administered By
University of Tasmania
Research Team
Pan Feng
Period
2019 - 2022
Grant Reference
1157535
Improving outcomes in patients with knee osteoarthritis: identifying pain phenotypes with relationships to long-term health outcomes (2018)$9,669
Description
Knee osteoarthritis is a highly heterogeneous condition characterised by a complex and multifactorial nature. The pain experience in knee osteoarthritis is similarly individualized and complex; some patients may present with pain that appears attributable to classic signs of joint damage, while others may present with pain due to psychological distress or central mechanisms. However, whether these variables (or interactions between variables) are representative of different pain phenotypes in knee osteoarthritis and whether patients with distinct pain phenotypes have different risk for long-term health outcomes are unknown. This project aims to identify the pain phenotypes in OA patients and compare the risk of long-term health outcomes between different pain phenotypes. This study will help clinicians better prioritize and target interventions to individual patients and will lead to better outcomes and fewer treatment complications currently associates with pharmaceutical and surgical interventions that are widely used to treat knee osteoarthritis.
Funding
University of Tasmania ($9,669)
Scheme
Grant- Research Enhancement Program
Administered By
University of Tasmania
Research Team
Pan Feng; Jones Graeme; Winzenberg TM; Tian Jing; Aitken D
Year
2018
Farrell Family Senior Research Fellow (2017 - 2018)$144,000
Description
Osteoarthritis (OA) is a highly burdensome condition in Australia. Despite this, its aetiology is poorly understood and no disease-modifying drugs are currently available. This research program is based on an observational study to understand OA pathogenesis and to determine treatments to reduce pain and slow structural changes in people with OA. TASOAC study (the Tasmanian Older Adult Cohort study), examines predictors of pain and knee structural changes over time using unique 10-year follow-up magnetic resonance imaging (MRI) measures. The cohort consists of both men and women selected randomly. Initial measures were carried out in 2002 and a second and third follow-up visit took place at 2.6, 5.1 and 10.7 years later. The investigation can further our understanding of OA pathogenesis and its symptoms allowing the identification of novel therapeutic interventions that will prevent the condition or the pain it causes, or at least limit progression to end-stage disease requiring joint replacement.
Funding
The Trustee for Farrell Foundation ($144,000)
Scheme
Donation - Institutional
Administered By
University of Tasmania
Research Team
Pan Feng
Period
2017 - 2018
Effects of krill oil supplementation versus placebo on knee pain and effusion in patients with symptomatic knee osteoarthritis (2017)$50,000
Description
My Fellowship application is based on a National Health and Medical Research Council (NHMRC) funded clinical trial ($751,491), a randomised trial of krill oil for osteoarthritis of the knee. Knee osteoarthritis (OA) is a significant and increasing cause of pain and disability in the aging Australian population, but interventions aimed at structural modification have been disappointing. Pilot data shows that krill oil reduces knee pain and systemic inflammation after 30 days, suggesting that an approach targeted at specific mechanisms of disease is effective in reducing painful OA. However, this pilot study was short, did not collect any data on structural factors, and included patients with a variety of disorders. The aim of this study is to compare, using a randomised, placebo-controlled double-blind design over six months, the efficacy of krill oil vs placebo in the treatment of OA of the knee in 260 patients with clinical knee OA, significant knee pain and effusions, both with regard to control of symptoms and localised inflammation.
Funding
Arthritis Australia ($50,000)
Scheme
Fellowship-Research
Administered By
University of Tasmania
Research Team
Pan Feng; Jones Graeme
Year
2017

Research Supervision

Dr Pan is currently co-supervising one PhD and one honours student as a primary supervisor.

Current

3

Current

DegreeTitleCommenced
PhDDo PUFAs Intake With Diet Play a Positive Effect in Preventing Non-alcoholic Fatty Liver Disease in Adolescents?2017
PhDCorrelates and Relevance of MicroCT Measurement in Older Adults2017
MastersEpidemiology of Hand Osteoarthritis2021