Profiles

Heinrich Korner

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Heinrich Korner

Heinrich Korner

Professor
Menzies Institute for Medical Research

Medical Science 2 (MS2) , Hobart CBD Campuses

+61 3 6226 4698 (phone)

+61362267704 (fax)

Heinrich.Korner@utas.edu.au

Inflammation is the process by which the body recognises an infection or tissue damage and actively recruits cells and initiates processes of the immune system to respond to it. Inflammation is usually the first step in the body's immune response. Its most recognisable early manifestations are redness at the site of infection or swelling around an injury.

Professor Heinrich Korner's research investigates the steps in the body’s inflammatory response, the molecular agents involved, and what happens when this process goes wrong.

Inflammation is a vital part of the normal immune response and it is central to the process by which the body heals itself. It also generates immunity to future incursions of disease agents.

However, chronic inflammation – when inflammation is triggered unnecessarily, or when it goes on too long – can lead to auto-immunity. In this condition, the cells of the immune system and the toxic chemicals they produce, which normally fight off infectious microbes, instead turn on the body’s own tissues.

'No one really knows what causes auto-immune diseases; causality has not been conclusively established,' Professor Korner says.

Rheumatoid arthritis is a good example of an auto-immune condition linked to chronic inflammation. Multiple sclerosis (MS) is another autoimmune disease which affects the central nervous system.

Professor Korner has studied the role of tumour necrosis factor (TNF), one of a group of molecules called cytokines, which coordinates the normal process of inflammation. His research demonstrated that TNF plays a key role in the process by which a class of immune cells known as macrophages switches to a pro-inflammation response. In mice in which the gene for TNF has been deactivated (TNF-knockout mice), a large proportion of the macrophages do not make this shift to the pro-inflammation state. As a consequence, the immune response is far less effective, particularly against intra-cellular pathogens.

Over-expression of TNF may, however, be one of the triggering events for autoimmunity in conditions like rheumatoid arthritis. A new class of drugs has been developed to suppress TNF and these drugs have been successful in suppressing rheumatoid arthritis. What is less well understood, however, is how anti-TNF therapy might compromise the immune system’s ability to perform its normal function, similar to the situation in the TNF-knockout mice.

Professor Korner is also carrying out research into the link between multiple sclerosis and vitamin D. In MS, the mechanism by which the immune system is triggered to attack the cells of the body's own nervous system remains a mystery. However, it is assumed to be associated with a deficiency of vitamin D. Professor Korner has shown that vitamin D acts as an anti-inflammatory agent, at least in tissue cultures. However, he is cautious about suggesting that vitamin D could be used to treat or prevent MS.

'MS is a complex disease and these results have only been shown in vitro. There is a lot we don't know about what goes on in a real person and how genetic, environmental and other factors all interact.'

Professor Korner is also collaborating in research investigating another group of cytokines, known as interleukins. Specifically, this research has shown that in mice lacking a certain kind of inflammasome – a large protein complex that is involved in the activation and secretion of interleukin – inflammation in the bowel can develop into bowel cancer.

'The link between inflammation and cancer is unexpected,' he says. 'This research is at an early stage and much more work needs to be done to understand the underlying connection.'

Professor Heinrich Korner is an Immunologist interested in inflammation, Autoimmunity and Immune defence against parasites.

Biography

Before joining the University of Tasmania, Heinrich studied Biology at the University of Wuerzburg, Germany, and completed his PhD thesis at the Institute for Virology and Immunology. After completing a post doctoral period at the Max-Planck-Institute in Freiburg, he moved to Australia and established gene-deficient mouse strains in the laboratory of Dr Jon Sedgwick at the Centenary Institute in Sydney. In 1998 he went back to Germany to establish his own research laboratory. In 2003, he left again for Australia after being appointed to a tenured position at James Cook University, Townsville Australia. In 2011 he relocated to the University of Tasmania following his appointment as New Star Professor at the Menzies Institute for Medical Research.

Career summary

Qualifications

  • PhD,  University of Wuerzburg, Germany, 1990. Thesis: Analysis of the role of CD4-positive T cells in the Coronavirus-induced encephalomyelitis of the Lewis rat

Languages (other than English)

German

Memberships

Professional practice

  • German Society of Immunology (1992- present) 
  • German Society of Virology (1992-2003)
  • Australasian Society of Immunology (Member of the ASI Council) (1993-1997; 2004- present)
  • Australian Society for Parasitology (2014- present)

Other

  • Lupus Society of Tasmania 
  • MS Society of Australia

Administrative expertise

  • NHMRC review panel 
  • German Research Foundation DFG review panel

Teaching

Immunology, Biochemistry, Molecular Biology, Autoimmunity, Allergy

Teaching expertise

Heinrich has extensive experience in the coordination of and development of units for a range of subjects.

View more on Professor Heinrich Korner in WARP

Expertise

  • Immunology of parasitic diseases
  • Autoimmunity
    • Multiple sclerosis (MS) 
    • Systemic Lupus Erythematosus (SLE)

Research Themes

Heinrich's research aligns to the University's research theme of Better Health. His research is interested in inflammation in general and he uses different models of infection and autoimmunity to better understand the contributions of the different components of the immune system.

Collaboration

Prof Korner has excellent research connections nationally as well as internationally. He collaborates with Prof Robert Brink (Garvan Institute, Sydney), Assoc Prof Matthew Cook and Prof Carola Vinuesa (ANU, Canberra) a well as Assoc Prof Dave Tarlinton (WEHI, Melbourne) to investigate the role of chemokine receptors. Furthermore, he has collaborations with Assoc Prof Matthew Sweet (IMB, Brisbane) and Dr. Antje Blumenthal (Diamantina, Brisbane) and Prof. Christian Bogdan (Erlangen, Germany) on his project examining the role of TNF in macrophage maturation. Finally, he works with Dr David Sacks (NIH, USA), Prof Mark Jenkins (University of Minesota, USA), Prof. Dale Godfrey and Assoc Prof Chris Engwerda on a project to develop a better way to study the memory response to L. major which will be important for vaccine development. Many of these collaborations have resulted in joint publications.

Fields of Research

  • Immunology (110799)
  • Innate Immunity (110707)
  • Cellular Immunology (110704)
  • Allergy (110701)
  • Autoimmunity (110703)
  • Central Nervous System (110903)
  • Humoural Immunology and Immunochemistry (110705)
  • Animal Physiology - Systems (060603)
  • Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies) (110702)
  • Infectious Diseases (110309)
  • Pharmaceutical Sciences (111504)
  • Cell Development, Proliferation and Death (060103)
  • Cell Neurochemistry (060105)
  • Medical Parasitology (110803)
  • Haematology (110202)
  • Medical and Health Sciences (119999)
  • Biochemistry and Cell Biology (060199)
  • Animal Immunology (060804)
  • Medical Biotechnology (100499)
  • Metabolic Medicine (110107)
  • Cancer Cell Biology (111201)
  • Rheumatology and Arthritis (110322)
  • Genetics (060499)
  • Epigenetics (incl. Genome Methylation and Epigenomics) (060404)
  • Genome Structure and Regulation (060407)
  • Cardiorespiratory Medicine and Haematology (110299)
  • Medical Physiology (111699)

Research Objectives

  • Infectious Diseases (920109)
  • Immune System and Allergy (920108)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Digestive System Disorders (920105)
  • Nervous System and Disorders (920111)
  • Expanding Knowledge in the Biological Sciences (970106)
  • Allied Health Therapies (excl. Mental Health Services) (920201)
  • Clinical Health (Organs, Diseases and Abnormal Conditions) (920199)
  • Cancer and Related Disorders (920102)
  • Public Health (excl. Specific Population Health) (920499)
  • Skeletal System and Disorders (incl. Arthritis) (920116)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Flora, Fauna and Biodiversity at Regional or Larger Scales (960805)
  • Blood Disorders (920101)
  • Respiratory System and Diseases (incl. Asthma) (920115)
  • Expanding Knowledge in Psychology and Cognitive Sciences (970117)

Publications

Prof Korner's work has produced a large number of high quality publications.  He has been appointed as
Reviewing Editor for Frontiers and reviews for scientific journals such as Immunology and Cell Biology, Journal of Immunology, European Journal of Immunology, Trends in Parasitology, PLoS One, PLoS Pathogen, Parasite Immunology.

Total publications

123

Journal Article

(119 outputs)
YearCitationAltmetrics
2019Lee AYS, Korner H, 'The CCR6-CCL20 axis in humoral immunity and T-B cell immunobiology', Immunobiology, 224, (3) pp. 449-454. ISSN 0171-2985 (2019) [Refereed Article]

DOI: 10.1016/j.imbio.2019.01.005 [eCite] [Details]

Citations: Scopus - 8Web of Science - 5

Co-authors: Lee AYS

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2019Li M, Dong Y, Chen Z, Meng L, Liu X, et al., 'MicroRNA-31 negatively regulates Interleukin-34 expression in vitro', Immunological Investigations pp. 1-11. ISSN 0882-0139 (2019) [Refereed Article]

DOI: 10.1080/08820139.2019.1578230 [eCite] [Details]

Citations: Web of Science - 3

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2019Li X, Darby J, Lyons AB, Woods GM, Korner H, 'TNF may negatively regulate phagocytosis of Devil Facial Tumour Disease cells by activated macrophages', Immunological Investigations, 48, (7) pp. 691-703. ISSN 0882-0139 (2019) [Refereed Article]

DOI: 10.1080/08820139.2018.1515222 [eCite] [Details]

Citations: Scopus - 2Web of Science - 3

Co-authors: Darby J; Lyons AB; Woods GM

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2019Lu M, McComish BJ, Burdon KP, Taylor BV, Korner H, 'The association between vitamin D and multiple sclerosis risk: 1,25(OH)2D3 induces super-enhancers bound by VDR', Frontiers in Immunology, 10 Article 488. ISSN 1664-3224 (2019) [Refereed Article]

DOI: 10.3389/fimmu.2019.00488 [eCite] [Details]

Citations: Scopus - 4Web of Science - 2

Co-authors: McComish BJ; Burdon KP; Taylor BV

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2019Mao W, Zhang J, Korner H, Jiang Y, Ying S, 'The emerging role of voltage-gated sodium channels in tumor biology', Frontiers in Oncology, 9, (March) Article 124. ISSN 2234-943X (2019) [Refereed Article]

DOI: 10.3389/fonc.2019.00124 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

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2019Wang X, Iyer A, Lyons AB, Korner H, Wei W, 'Emerging roles for G-protein coupled receptors in development and activation of macrophages', Frontiers in Immunology, 10 Article 2031. ISSN 1664-3224 (2019) [Refereed Article]

DOI: 10.3389/fimmu.2019.02031 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Lyons AB

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2019Zhang J, Mao W, Dai Y, Qian C, Dong Y, et al., 'Voltage-gated sodium channel Nav1.5 promotes proliferation, migration and invasion of oral squamous cell carcinoma', Acta Biochimica et Biophysica Sinica, 51, (6) pp. 562-570. ISSN 1672-9145 (2019) [Refereed Article]

DOI: 10.1093/abbs/gmz044 [eCite] [Details]

Citations: Scopus - 1Web of Science - 2

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2018Hu S, Marshall C, Darby J, Wei W, Lyons AB, et al., 'Absence of tumor necrosis factor supports alternative activation of macrophages in the liver after infection with Leishmania major', Frontiers in Immunology, 9 Article 1. ISSN 1664-3224 (2018) [Refereed Article]

DOI: 10.3389/fimmu.2018.00001 [eCite] [Details]

Citations: Scopus - 7Web of Science - 6

Co-authors: Hu S; Marshall C; Darby J; Lyons AB

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2018Lu M, Taylor BV, Korner H, 'Genomic effects of the vitamin D receptor: Potentially the link between vitamin D, immune cells, and multiple sclerosis', Frontiers in Immunology, 9 Article 477. ISSN 1664-3224 (2018) [Refereed Article]

DOI: 10.3389/fimmu.2018.00477 [eCite] [Details]

Citations: Scopus - 16Web of Science - 15

Co-authors: Lu M; Taylor BV

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2018Perera AP, Sajnani K, Dickinson J, Eri R, Korner H, 'NLRP3 inflammasome in colitis and colitis-associated colorectal cancer', Mammalian Genome, 29, (11-12) pp. 817-830. ISSN 0938-8990 (2018) [Refereed Article]

DOI: 10.1007/s00335-018-9783-2 [eCite] [Details]

Citations: Scopus - 7Web of Science - 2

Co-authors: Perera AP; Dickinson J; Eri R

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2018Tai Y, Wang Q, Korner H, Zhang L, Wei W, 'Molecular mechanisms of T cells activation by dendritic cells in autoimmune diseases', Frontiers in Pharmacology, 9, (June) Article 642. ISSN 1663-9812 (2018) [Refereed Article]

DOI: 10.3389/fphar.2018.00642 [eCite] [Details]

Citations: Scopus - 25Web of Science - 19

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2017Gatica-Andrades M, Vagenas D, Kling J, Nguyen TTK, Benham H, et al., 'WNT ligands contribute to the immune response during septic shock and amplify endotoxemia-driven inflammation in mice', Blood Advances, 1, (16) pp. 1274-1286. ISSN 2473-9529 (2017) [Refereed Article]

DOI: 10.1182/bloodadvances.2017006163 [eCite] [Details]

Citations: Scopus - 11Web of Science - 11

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2017Hu S, Wei W, Korner H, 'The role of monocytes in models of infection by protozoan parasites', Molecular Immunology, 88 pp. 174-184. ISSN 0161-5890 (2017) [Refereed Article]

DOI: 10.1016/j.molimm.2017.06.020 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Hu S

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2017Lee AYS, Bannan JL, Adams MJ, Korner H, 'Expression of CCR6 on B cells in systemic lupus erythematosus patients', Clinical Rheumatology, 36, (6) pp. 1453-1456. ISSN 0770-3198 (2017) [Refereed Article]

DOI: 10.1007/s10067-017-3652-3 [eCite] [Details]

Citations: Scopus - 4Web of Science - 5

Co-authors: Lee AYS; Bannan JL; Adams MJ

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2017Lee AYS, Korner H, 'CCR6/CCL20 chemokine axis in human immunodeficiency virus immunity and pathogenesis', Journal of General Virology, 98, (3) pp. 338-344. ISSN 0022-1317 (2017) [Refereed Article]

DOI: 10.1099/jgv.0.000691 [eCite] [Details]

Citations: Scopus - 12Web of Science - 9

Co-authors: Lee AYS

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2017Lee AYS, Reimer D, Zehrer A, Lu M, Mielenz D, et al., 'Expression of membrane-bound CC chemokine ligand 20 on follicular T helper cells in T-B-cell conjugates', Frontiers in Immunology, 8 Article 1871. ISSN 1664-3224 (2017) [Refereed Article]

DOI: 10.3389/fimmu.2017.01871 [eCite] [Details]

Citations: Scopus - 3Web of Science - 2

Co-authors: Lee AYS; Zehrer A; Lu M

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2017Li M, Zhang D, Zhu M, Shen Y, Wei W, et al., 'Roles of SAMHD1 in antiviral defense, autoimmunity and cancer', Reviews in Medical Virology, 27, (4) Article e1931. ISSN 1052-9276 (2017) [Refereed Article]

DOI: 10.1002/rmv.1931 [eCite] [Details]

Citations: Scopus - 8Web of Science - 7

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2017Li X, Lyons AB, Woods GM, Korner H, 'The absence of TNF permits myeloid Arginase 1 expression in experimental L. monocytogenes infection', Immunobiology, 222, (8-9) pp. 913-917. ISSN 0171-2985 (2017) [Refereed Article]

DOI: 10.1016/j.imbio.2017.05.012 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Lyons AB; Woods GM

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2017Reimer D, Lee AYS, Bannan J, Fromm P, Kara EE, et al., 'Early CCR6 expression on B cells modulates germinal centre kinetics and efficient antibody responses', Immunology and Cell Biology, 95, (1) pp. 33-41. ISSN 0818-9641 (2017) [Refereed Article]

DOI: 10.1038/icb.2016.68 [eCite] [Details]

Citations: Scopus - 13Web of Science - 14

Co-authors: Lee AYS; Bannan J

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2017Zhang D, Li M, Dong Y, Zhang X, Liu X, et al., '1α,25-Dihydroxyvitamin D3 up-regulates IL-34 expression in SH-SY5Y neural cells', Innate Immunity, 23, (7) pp. 584-591. ISSN 1753-4259 (2017) [Refereed Article]

DOI: 10.1177/1753425917725391 [eCite] [Details]

Citations: Scopus - 6Web of Science - 5

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2016Fromm PD, Kling JC, Remke A, Bogdan C, Korner H, 'Fatal leishmaniasis in the absence of TNF despite a strong Th1 response', Frontiers in Microbiology, 6, (January) Article 1520. ISSN 1664-302X (2016) [Refereed Article]

DOI: 10.3389/fmicb.2015.01520 [eCite] [Details]

Citations: Scopus - 7Web of Science - 7

Co-authors: Kling JC; Remke A

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2016Ho YC, Ahuja KDK, Korner H, Adams MJ, 'β2GP1, anti-β2GP1 antibodies and platelets: key players in the antiphospholipid syndrome', Antibodies, 5, (12) pp. 1-16. ISSN 2073-4468 (2016) [Refereed Article]

DOI: 10.3390/antib5020012 [eCite] [Details]

Citations: Web of Science - 5

Co-authors: Ho YC; Ahuja KDK; Adams MJ

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2016Nauerth M, Wing K, Korner H, Busch DH, 'Relevance of the T cell receptor-ligand avidity for immunity to infection', Journal of Microbial & Biochemical Technology, 8, (2) pp. 131-135. ISSN 1948-5948 (2016) [Contribution to Refereed Journal]

DOI: 10.4172/1948-5948.1000275 [eCite] [Details]

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2016Schleicher U, Paduch K, Debus A, Obermeyer S, Konig T, et al., 'TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection', Cell Reports, 15, (5) pp. 1062-1075. ISSN 2211-1247 (2016) [Refereed Article]

DOI: 10.1016/j.celrep.2016.04.001 [eCite] [Details]

Citations: Scopus - 38Web of Science - 38

Co-authors: Kling JC

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2015Lee AYS, Phan TK, Hulett MD, Korner H, 'The relationship between CCR6 and its binding partners: Does the CCR6-CCL20 axis have to be extended?', Cytokine, 72, (1) pp. 97-101. ISSN 1043-4666 (2015) [Refereed Article]

DOI: 10.1016/j.cyto.2014.11.029 [eCite] [Details]

Citations: Scopus - 24Web of Science - 25

Co-authors: Lee AYS

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2015Shastri MD, Stewart N, Horne J, Zaidi STR, Sohal SS, et al., 'Non-anticoagulant fractions of enoxaparin suppress inflammatory cytokine release from peripheral blood mononuclear cells of allergic asthmatic individuals', PLoS One, 10, (6) Article e0128803. ISSN 1932-6203 (2015) [Refereed Article]

DOI: 10.1371/journal.pone.0128803 [eCite] [Details]

Citations: Scopus - 15Web of Science - 13

Co-authors: Shastri MD; Stewart N; Horne J; Zaidi STR; Sohal SS; Peterson GM; Gueven N; Patel RP

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2015Song J, Wu C, Korpos E, Zhang X, Agrawal SM, et al., 'Focal MMP-2 and MMP-9 activity at the blood-brain barrier promotes chemokine-induced leukocyte migration', Cell Reports, 10, (7) pp. 1040-1054. ISSN 2211-1247 (2015) [Refereed Article]

DOI: 10.1016/j.celrep.2015.01.037 [eCite] [Details]

Citations: Scopus - 68Web of Science - 68

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2015Wiede F, Roomberg A, Darby J, Gollan R, Korner H, 'Both Tumor Necrosis Factor Receptor Signaling Pathways Contribute to Mortality but not to Splenomegaly in Generalized Lymphoproliferative Disorder', Antibodies, 4, (1) pp. 1-10. ISSN 2073-4468 (2015) [Refereed Article]

DOI: 10.3390/antib4010001 [eCite] [Details]

Co-authors: Darby J

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2014Bunting MD, Comerford I, Kara EE, Korner H, McColl SR, 'CCR6 supports migration and differentiation of a subset of DN1 early thymocyte progenitors but is not required for thymic nTreg development', Immunology and Cell Biology, 92 pp. 489-498. ISSN 0818-9641 (2014) [Refereed Article]

DOI: 10.1038/icb.2014.14 [eCite] [Details]

Citations: Scopus - 5Web of Science - 4

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2014Kling JC, Darby J, Korner H, 'CCR7 facilitates the pro-inflammatory function of dendritic cells in experimental leishmaniasis', Parasite Immunology, 36, (4) pp. 177-185. ISSN 0141-9838 (2014) [Refereed Article]

DOI: 10.1111/pim.12097 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Kling JC; Darby J

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2014Lee AYS, Korner H, 'CCR6 and CCL20: emerging players in the pathogenesis of rheumatoid arthritis', Immunology and Cell Biology, 92, (4) pp. 354-358. ISSN 0818-9641 (2014) [Refereed Article]

DOI: 10.1038/icb.2013.97 [eCite] [Details]

Citations: Scopus - 33Web of Science - 33

Co-authors: Lee AYS

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2013Bunting MD, Comerford I, Seach N, Hammett MV, Asquith DL, et al., 'CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity', Blood, 121, (1) pp. 118-128. ISSN 0006-4971 (2013) [Refereed Article]

DOI: 10.1182/blood-2012-06-434886 [eCite] [Details]

Citations: Scopus - 28Web of Science - 27

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2013Camara ML, Corrigan F, Jaehne EJ, Jawahar MC, Anscomb H, et al., 'TNF-α and its receptors modulate complex behaviours and neurotrophins in transgenic mice', Psychoneuroendocrinology, 38, (12) pp. 3102-3114. ISSN 0306-4530 (2013) [Refereed Article]

DOI: 10.1016/j.psyneuen.2013.09.010 [eCite] [Details]

Citations: Scopus - 40Web of Science - 40

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2013Kling JC, Mack M, Korner H, 'The absence of CCR7 results in dysregulated monocyte migration and immunosuppression facilitating chronic cutaneous leishmaniasis', PLOS One, 8, (10) Article e79098. ISSN 1932-6203 (2013) [Refereed Article]

DOI: 10.1371/journal.pone.0079098 [eCite] [Details]

Citations: Scopus - 9Web of Science - 8

Co-authors: Kling JC

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2013Moran CS, Jose RJ, Moxon JV, Roomberg A, Norman PE, et al., 'Everolimus limits aortic aneurysm in the apolipoprotein E-deficient mouse by downregulating C-C chemokine receptor 2 positive monocytes', Arteriosclerosis, Thrombosis, and Vascular Biology, 33, (4) pp. 814-821. ISSN 1079-5642 (2013) [Refereed Article]

DOI: 10.1161/ATVBAHA.112.301006 [eCite] [Details]

Citations: Scopus - 30Web of Science - 29

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2013Pratama A, Ramiscal RR, Silva DG, Das SK, Athanasopoulos V, et al., 'Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation', Immunity, 38, (4) pp. 669-680. ISSN 1074-7613 (2013) [Refereed Article]

DOI: 10.1016/j.immuni.2013.01.011 [eCite] [Details]

Citations: Scopus - 86Web of Science - 87

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2013Wiede F, Fromm PD, Comerford I, Kara E, Bannan J, et al., 'CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse', Immunology and Cell Biology, 91, (5) pp. 335-339. ISSN 0818-9641 (2013) [Refereed Article]

DOI: 10.1038/icb.2013.14 [eCite] [Details]

Citations: Scopus - 17Web of Science - 15

Co-authors: Bannan J

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2012Baune BT, Camara ML, Eyre H, Jawahar C, Anscomb H, et al., 'Tumour necrosis factor - alpha mediated mechanisms of cognitive dysfunction', Translational Neuroscience, 3, (3) pp. 263-277. ISSN 2081-3856 (2012) [Refereed Article]

DOI: 10.2478/s13380-012-0027-8 [eCite] [Details]

Citations: Scopus - 28Web of Science - 25

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2012Fromm PD, Kling J, Mack M, Sedgwick JD, Korner H, 'Loss of TNF signaling facilitates the development of a novel Ly-6Clow macrophage population permissive for Leishmania major infection', Journal of Immunology, 188, (12) pp. 6258-6266. ISSN 0022-1767 (2012) [Refereed Article]

DOI: 10.4049/jimmunol.1100977 [eCite] [Details]

Citations: Scopus - 13Web of Science - 10

Co-authors: Kling J

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2012Laslett LL, Quinn SJ, Darian-Smith E, Kwok M, Fedorova T, et al., 'Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised controlled trial', Osteoarthritis and Cartilage: Journal of The Osteoarthritis Research Society International, 20, (11) pp. 1209-1216. ISSN 1063-4584 (2012) [Refereed Article]

DOI: 10.1016/j.joca.2012.07.019 [eCite] [Details]

Citations: Scopus - 11Web of Science - 12

Co-authors: Laslett LL; Darian-Smith E; Jones G

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2012Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, et al., 'Epithelial Cell-Derived IL-25, but Not Th17 Cell-Derived IL-17 or IL-17F, Is Crucial for Murine Asthma', Journal of Immunology, 189, (7) pp. 3641-3652. ISSN 0022-1767 (2012) [Refereed Article]

DOI: 10.4049/jimmunol.1200461 [eCite] [Details]

Citations: Scopus - 78Web of Science - 68

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2011Kling J, Gollan R, Fromm P, Korner H, 'Redundancy of interleukin-6 in the differentiation of T cell and monocyte subsets during cutaneous leishmaniasis ', Experimental Parasitology, 129, (3) pp. 270-276. ISSN 0014-4894 (2011) [Refereed Article]

DOI: 10.1016/j.exppara.2011.07.015 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

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2011Miranda-Hernandez S, Gerlach N, Fletcher JM, Biros E, Mack M, et al., 'Role for MyD88, TLR2 and TLR9 but not TLR1, TLR4 or TLR6 in Experimental Autoimmune Encephalomyelitis', Journal of Immunology, 187, (2) pp. 791-804. ISSN 0022-1767 (2011) [Refereed Article]

DOI: 10.4049/jimmunol.1001992 [eCite] [Details]

Citations: Scopus - 54Web of Science - 54

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2011Pisani MJ, Fromm PD, Mulyana Y, Clarke RJ, Korner H, et al., 'Mechanism of Cytotoxicity and Cellular Uptake of Lipophilic Inert Dinuclear Polypyridylruthenium(II) Complexes', ChemMedChem: chemistry enabling drug discovery, 6, (5) pp. 848-858. ISSN 1860-7179 (2011) [Refereed Article]

DOI: 10.1002/cmdc.201100053 [eCite] [Details]

Citations: Scopus - 60Web of Science - 57

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2010Comerford I, Nibbs RJB, Litchfield W, Bunting M, Harata-Lee Y, et al., 'The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses', Blood, 116, (20) pp. 4130-4140. ISSN 0006-4971 (2010) [Refereed Article]

DOI: 10.1182/blood-2010-01-264390 [eCite] [Details]

Citations: Scopus - 51Web of Science - 45

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2010Hansen E, Krautwald M, Maczurek AE, Stuchbury G, Fromm P, et al., 'A Versatile High Throughput Screening System for the Simultaneous Identification of Anti-Inflammatory and Neuroprotective Compounds', Journal of Alzheimer's Disease, 19, (2) pp. 451-464. ISSN 1387-2877 (2010) [Refereed Article]

DOI: 10.3233/JAD-2010-1233 [eCite] [Details]

Citations: Scopus - 14Web of Science - 13

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2010Korner H, McMorran B, Schluter D, Fromm P, 'The role of TNF in parasitic diseases: Still more questions than answers', International Journal for Parasitology, 40, (8) pp. 879-888. ISSN 0020-7519 (2010) [Refereed Article]

DOI: 10.1016/j.ijpara.2010.03.011 [eCite] [Details]

Citations: Scopus - 31Web of Science - 29

Co-authors: McMorran B

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2010Markey KA, Burman AC, Banovic T, Kuns RD, Raffelt NC, et al., 'Soluble lymphotoxin is an important effector molecule in GVHD and GVL', Blood, 115, (1) pp. 122-132. ISSN 0006-4971 (2010) [Refereed Article]

DOI: 10.1182/blood-2009-01-199927 [eCite] [Details]

Citations: Scopus - 27Web of Science - 24

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2010Roomberg A, Kling J, Fromm P, Korner H, 'Tumor necrosis factor negative bone marrow-derived dendritic cells exhibit deficient IL-10 expression', Immunology and Cell Biology, 88, (8) pp. 842-845. ISSN 0818-9641 (2010) [Refereed Article]

DOI: 10.1038/icb.2010.54 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

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2010Weisel FJ, Appelt UK, Schneider AM, Horlitz JU, van Rooijen N, et al., 'Unique requirements for reactivation of virus-specific memory B lymphocytes', Journal of Immunology, 185, (7) pp. 4011-4021. ISSN 0022-1767 (2010) [Refereed Article]

DOI: 10.4049/jimmunol.1001540 [eCite] [Details]

Citations: Scopus - 21Web of Science - 21

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2009Liston A, Kohler RE, Townley S, Haylock-Jacobs S, Comerford I, et al., 'Inhibition of CCR6 Function Reduces the Severity of Experimental Autoimmune Encephalomyelitis via Effects on the Priming Phase of the Immune Response', Journal of Immunology, 182, (5) pp. 3121-3130. ISSN 0022-1767 (2009) [Refereed Article]

DOI: 10.4049/jimmunol.0713169 [eCite] [Details]

Citations: Scopus - 85Web of Science - 78

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2009Wiede F, Roomberg A, Cretney E, Lechner A, Fromm P, et al., 'Age-dependent, polyclonal hyperactivation of T cells is reduced in TNF-negative gld/gld mice', Journal of Leukocyte Biology, 85, (1) pp. 108-116. ISSN 0741-5400 (2009) [Refereed Article]

DOI: 10.1189/jlb.0107018 [eCite] [Details]

Citations: Scopus - 7Web of Science - 7

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2008Baune B, Wiede F, Braun A, Golledge J, Arolt V, et al., 'Cognitive dysfunction in mice deficient for TNF and its receptors', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics , 147B, (7) pp. 1056-1064. ISSN 1552-4841 (2008) [Refereed Article]

DOI: 10.1002/ajmg.b.30712 [eCite] [Details]

Citations: Scopus - 86Web of Science - 90

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2008Berbaurn K, Shanmugam K, Stuchbury G, Wiede F, Korner H, et al., 'Induction of novel cytokines and chemokines by advanced glycation endproducts determined with a cytometric bead array', Cytokine, 41, (3) pp. 198-203. ISSN 1043-4666 (2008) [Refereed Article]

DOI: 10.1016/j.cyto.2007.11.012 [eCite] [Details]

Citations: Scopus - 42Web of Science - 37

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2008McAfoose J, Korner H, Baune BT, 'The effects of TNF deficiency on age-related cognitive performance', Psychoneuroendocrinology, 34, (4) pp. 615-619. ISSN 0306-4530 (2008) [Refereed Article]

DOI: 10.1016/j.psyneuen.2008.10.006 [eCite] [Details]

Citations: Scopus - 35Web of Science - 32

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2008Ritter U, Lechner A, Scharl K, Kiafard Z, Zwirner J, et al., 'TNF controls the infiltration of dendritic cells into the site of Leishmania major infection', Medical Microbiology and Immunology, 197, (1) pp. 29-37. ISSN 0300-8584 (2008) [Refereed Article]

DOI: 10.1007/s00430-007-0056-z [eCite] [Details]

Citations: Scopus - 14Web of Science - 10

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2008Vallabhapurapu S, Powolny-Budnicka I, Riemann M, Schmid RM, Paxian S, et al., 'Rel/NF-kappa B family member RelA regulates NK1.1(-) to NK1.1(+) transition as well as IL-15-induced expansion of NKT cells', European Journal of Immunology, 38, (12) pp. 3508-3519. ISSN 0014-2980 (2008) [Refereed Article]

DOI: 10.1002/eji.200737830 [eCite] [Details]

Citations: Scopus - 39Web of Science - 39

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2007Lechner A, Ritter U, Varona R, Marquez G, Bogdan C, et al., 'Protective Immunity and Delayed Type Hypersensitivity Reaction are Uncoupled in Experimental Leishmania major Infection of CCR6-negative Mice', Microbes and Infection: A Journal on Infectious Agents and Host Defenses, 9, (3) pp. 291-299. ISSN 1286-4579 (2007) [Refereed Article]

DOI: 10.1016/j.micinf.2006.12.002 [eCite] [Details]

Citations: Scopus - 14Web of Science - 14

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2007Wiede F, Vana K, Sedger LM, Lechner A, Korner H, 'TNF-dependent overexpression of CCL21 is an underlying cause of progressive lymphoaccumulation in generalized lymphoproliferative disorder', European Journal of Immunology, 37, (2) pp. 351-357. ISSN 0014-2980 (2007) [Refereed Article]

DOI: 10.1002/eji.200636218 [eCite] [Details]

Citations: Scopus - 7Web of Science - 7

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2007Xu G, Liu D, Fan Y, Yang X, Korner H, et al., 'Lymphotoxin alpha beta 2 (Membrane lymphotoxin) is critically important for resistance to Leishmania major infection in mice', Journal of Immunology, 179, (8) pp. 5358-5366. ISSN 0022-1767 (2007) [Refereed Article]

DOI: 10.4049/jimmunol.179.8.5358 [eCite] [Details]

Citations: Scopus - 14Web of Science - 15

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2007Xu G, Liu D, Okwor I, Wang Y, Korner H, et al., 'LIGHT is critical for IL-12 production by dendritic cells, optimal CD4(+) th1 cell response, and resistance to leishmania major', Journal of Immunology, 179, (10) pp. 6901-6909. ISSN 0022-1767 (2007) [Refereed Article]

DOI: 10.4049/jimmunol.179.10.6901 [eCite] [Details]

Citations: Scopus - 37Web of Science - 37

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2006Virna S, Deckert M, Luetjen S, Soltek S, Foulds KE, et al., 'TNF is important for pathogen control and limits brain damage in murine cerebral listeriosis', Journal of Immunology, 177, (6) pp. 3972-3982 . ISSN 0022-1767 (2006) [Refereed Article]

DOI: 10.4049/jimmunol.177.6.3972 [eCite] [Details]

Citations: Scopus - 29Web of Science - 24

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2005Korner H, Ritter U, 'TNF controls the inflammatory response in peripheral tissues in experimental cutaneous leishmaniasis ', Tissue Antigens, 66, (5) pp. 469. ISSN 0001-2815 (2005) [Letter or Note in Journal]

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2005Pabst O, Herbrand H, Worbs T, Friedrichsen M, Yan S, et al., 'Cryptopatches and isolated lymphoid follicles: dynamic lymphoid tissues dispensable for the generation of intraepithelial lymphocytes', European Journal of Immunology, 35, (1) pp. 98-107. ISSN 0014-2980 (2005) [Refereed Article]

DOI: 10.1002/eji.200425432 [eCite] [Details]

Citations: Scopus - 136Web of Science - 124

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2005Stenzel W, Soltek S, Miletic H, Hermann MM, Korner H, et al., 'An essential role for tumor necrosis factor in the formation of experimental murine Staphylococcus aureus-induced brain abscess and clearance', Journal of Neuropathology and Experimental Neurology, 64, (1) pp. 27-36. ISSN 0022-3069 (2005) [Refereed Article]

DOI: 10.1093/jnen/64.1.27 [eCite] [Details]

Citations: Scopus - 31Web of Science - 28

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2005Stenzel W, Soltek S, Miletic H, Hermann MM, Korner H, et al., 'An essential role for tumor necrosis factor in the formation of experimental murine Staphylococcus aureus-induced brain abscess and clearance', Acta Neuropathologica, 110, (3) pp. 341. ISSN 0001-6322 (2005) [Letter or Note in Journal]

DOI: 10.1007/s00401-005-1067-8 [eCite] [Details]

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2005Wiede F, Vana K, Korner H, 'The attenuation of the gld syndrome in the absence of TNF', Tissue Antigens, 66, (5) pp. 589. ISSN 0001-2815 (2005) [Letter or Note in Journal]

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2005Wilhelm P, Wiede F, Meissner A, Donhauser N, Bogdan C, et al., 'TNF but not Fas ligand provides protective anti-L-major immunity in C57BL/6 mice ', Microbes and Infection: A Journal on Infectious Agents and Host Defenses, 7, (15) pp. 1461-1468. ISSN 1286-4579 (2005) [Refereed Article]

DOI: 10.1016/j.micinf.2005.05.005 [eCite] [Details]

Citations: Scopus - 14Web of Science - 12

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2004Ritter U, Mattner J, Rocha JS, Bogdan C, Korner H, 'The Control of Leishmania (Leishmania) major by TNF in vivo is dependent on the Parasite Strain', Microbes and Infection: A Journal on Infectious Agents and Host Defenses, 6, (6) pp. 559-565 . ISSN 1286-4579 (2004) [Refereed Article]

DOI: 10.1016/j.micinf.2004.02.008 [eCite] [Details]

Citations: Scopus - 42Web of Science - 36

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2004Ritter U, Meissner A, Scheidig C, Korner H, 'CD8 alpha- and Langerin-negative dendritic cells, but not Langerhans cells, act as principal antigen-presenting cells in leishmaniasis', European Journal of Immunology, 34, (6) pp. 1542-1550. ISSN 0014-2980 (2004) [Refereed Article]

DOI: 10.1002/eji.200324586 [eCite] [Details]

Citations: Scopus - 124Web of Science - 116

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2004Ritter U, Wiede F, Mielenz D, Kiafard Z, Zwirner J, et al., 'Analysis of the CCR7 expression on murine bone marrow-derived and spleen dendritic cells ', Journal of Leukocyte Biology, 76, (2) pp. 472-476. ISSN 0741-5400 (2004) [Refereed Article]

DOI: 10.1189/jlb.0104037 [eCite] [Details]

Citations: Scopus - 34Web of Science - 34

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2004Virna S, Soltek S, Korner H, Deckert M, Schluter D, 'Tumor necrosis factor is important for pathogen control, but does not induce brain damage in murine cerebral listeriosis', International Journal of Medical Microbiology, 294, (Supplement 39) pp. 197. ISSN 1438-4221 (2004) [Letter or Note in Journal]

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2003Meissner A, Zilles O, Varona R, Jozefowski K, Ritter U, et al., 'CC chemokine ligand 20 partially controls adhesion of naive B cells to activated endothelial cells under shear stress', Blood, 102, (8) pp. 2724-2727. ISSN 0006-4971 (2003) [Refereed Article]

DOI: 10.1182/blood-2003-01-0007 [eCite] [Details]

Citations: Scopus - 30Web of Science - 28

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2003Ritter U, Meissner A, Ott J, Korner H, 'Analysis of the maturation process of dendritic cells deficient for TNF and lymphotoxin-alpha reveals an essential role for TNF', Journal of Leukocyte Biology, 74, (2) pp. 216-222. ISSN 0741-5400 (2003) [Refereed Article]

DOI: 10.1189/jlb.1202587 [eCite] [Details]

Citations: Scopus - 60Web of Science - 56

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2003Schluter D, Kwok LY, Lutjen S, Soltek S, Hoffmann S, et al., 'Both lymphotoxin-alpha and TNF are crucial for control of Toxoplasma gondii in the central nervous system', Journal of Immunology, 170, (12) pp. 6172-6182. ISSN 0022-1767 (2003) [Refereed Article]

DOI: 10.4049/jimmunol.170.12.6172 [eCite] [Details]

Citations: Web of Science - 68

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2002Brakebusch C, Fillatreau S, Potocnik AJ, Bungartz G, Wilhelm P, et al., 'Beta-1 Integrin Is Not Essential for Hematopoiesis but Is Necessary for the T Cell-Dependent IgM Antibody Response', Immunity, 16, (3) pp. 465-477. ISSN 1074-7613 (2002) [Refereed Article]

DOI: 10.1016/S1074-7613(02)00281-9 [eCite] [Details]

Citations: Scopus - 55Web of Science - 55

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2002Cheminay C, Schoen M, Hensel M, Wandersee-Steinhauser A, Ritter U, et al., 'Migration of Salmonella typhimurioum-harboring bone marrow-derived dendritic cells towards the chemokines CCL19 and CCL21', Microbial Pathogenesis , 32, (5) pp. 207-218. ISSN 0882-4010 (2002) [Refereed Article]

DOI: 10.1006/mpat.2002.0497 [eCite] [Details]

Citations: Scopus - 29Web of Science - 28

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2002Ritter U, Korner H, 'Divergent expression of inflammatory dermal chemokines in cutaneous leishmaniasis', Parasite Immunology, 24, (6) pp. 295-301. ISSN 0141-9838 (2002) [Refereed Article]

DOI: 10.1046/j.1365-3024.2002.00467.x [eCite] [Details]

Citations: Scopus - 62Web of Science - 55

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2002Sobek V, Balkow S, Korner H, Simon MM, 'Antigen-induced cell death of T effector cells in vitro proceeds via the Fas pathway, requires endogenous interferon-gamma and is independent of perforin and granzymes', European Journal of Immunology, 32, (9) pp. 2490-2499 . ISSN 0014-2980 (2002) [Refereed Article]

DOI: 10.1002/1521-4141(200209)32:9<2490::AID-IMMU2490>3.0.CO;2-G [eCite] [Details]

Citations: Web of Science - 23

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2002Wilhelm P, Riminton DS, Ritter U, Lemckert FA, Scheidig C, et al., 'Membrane lymphotoxin contributes to anti-leishmanial immunity by controlling structural integrity of lymphoid organs', European Journal of Immunology, 32, (7) pp. 1993-2003. ISSN 0014-2980 (2002) [Refereed Article]

DOI: 10.1002/1521-4141(200207)32:7<1993::AID-IMMU1993>3.0.CO;2-F [eCite] [Details]

Citations: Web of Science - 27

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2001Gabor MJ, Sedgwick JD, Lemckert FA, Godfrey DI, Korner H, 'Lymphotoxin controls alpha(E)beta 7-integrin expression by peripheral CD8(+) T cells', Immunology and Cell Biology, 79, (4) pp. 323-331. ISSN 0818-9641 (2001) [Refereed Article]

DOI: 10.1046/j.1440-1711.2001.01018.x [eCite] [Details]

Citations: Scopus - 7Web of Science - 6

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2001Korner H, Winkler TH, Sedgwick JD, Rollinghoff M, Basten A, et al., 'Recirculating and marginal zone B cell populations can be established and maintained independently of primary and secondary follicles', Immunology and Cell Biology, 79, (1) pp. 54-61. ISSN 0818-9641 (2001) [Refereed Article]

DOI: 10.1046/j.1440-1711.2001.00984.x [eCite] [Details]

Citations: Scopus - 17Web of Science - 12

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2001Ruuls SR, Hoek RM, Ngo VN, McNeil T, Lucian LA, et al., 'Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation', Immunity, 15, (4) pp. 533-543. ISSN 1074-7613 (2001) [Refereed Article]

DOI: 10.1016/S1074-7613(01)00215-1 [eCite] [Details]

Citations: Scopus - 210Web of Science - 201

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2001Wilhelm P, Ritter U, Labbow S, Donhauser N, Rollinghoff M, et al., 'Rapidly fatal Leishmaniasis in resistant C57BL/6 mice lacking TNF', Journal of Immunology, 166, (6) pp. 4012-4019. ISSN 0022-1767 (2001) [Refereed Article]

DOI: 10.4049/jimmunol.166.6.4012 [eCite] [Details]

Citations: Scopus - 138Web of Science - 135

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2000Korner H, Cretney E, Wilhelm P, Kelly JM, Rollinghoff M, et al., 'Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotype', The Journal of Experimental Medicine, 191, (1) pp. 89-96. ISSN 0022-1007 (2000) [Refereed Article]

DOI: 10.1084/jem.191.1.89 [eCite] [Details]

Citations: Scopus - 49Web of Science - 51

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2000Reich A, Korner H, Sedgwick JD, Pircher H, 'Immune down-regulation and peripheral deletion of CD8 T cells does not require TNF receptor-ligand interactions nor CD95 (Fas, APO-1)', European Journal of Immunology, 30, (2) pp. 678-682. ISSN 0014-2980 (2000) [Refereed Article]

DOI: 10.1002/1521-4141(200002)30:2<678::AID-IMMU678>3.0.CO;2-Q [eCite] [Details]

Citations: Web of Science - 60

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2000Sedgwick JD, Riminton DS, Cyster JG, Korner H, 'Tumor necrosis factor: a master-regulator of leukocyte movement', Immunology Today, 21, (3) pp. 110-113. ISSN 0167-5699 (2000) [Refereed Article]

DOI: 10.1016/S0167-5699(99)01573-X [eCite] [Details]

Citations: Scopus - 197Web of Science - 183

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1999Bean AGD, Roach DR, Briscoe H, France MP, Korner H, et al., 'Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin', Journal of Immunology, 162, (6) pp. 3504-3511. ISSN 0022-1767 (1999) [Refereed Article]

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Citations: Web of Science - 462

1999Ching LM, Goldsmith D, Joseph WR, Korner H, Sedgwick JD, et al., 'Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knockout mice', Cancer Research, 59, (14) pp. 3304-3307. ISSN 0008-5472 (1999) [Refereed Article]

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Citations: Web of Science - 84

1999Hayder H, Blanden RV, Korner H, Riminton DS, Sedgwick JD, et al., 'Adenovirus-induced liver pathology is mediated through TNF receptors I and II but is independent of TNF or lymphotoxin', Journal of Immunology, 163, (3) pp. 1516-1520. ISSN 0022-1767 (1999) [Refereed Article]

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Citations: Web of Science - 18

1999Korner H, Smythe M, Sedgwick JD, 'Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotype', Immunobiology: Experimental and Clinical, 200 pp. 461. ISSN 0171-2985 (1999) [Letter or Note in Journal]

[eCite] [Details]

1999Ngo VN, Korner H, Gunn MD, Schmidt KN, Riminton DS, et al., 'Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen', The Journal of Experimental Medicine, 189, (2) pp. 403-412. ISSN 0022-1007 (1999) [Refereed Article]

DOI: 10.1084/jem.189.2.403 [eCite] [Details]

Citations: Scopus - 456Web of Science - 446

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1999Smyth MJ, Johnstone RW, Cretney E, Haynes NM, Sedgwick JD, et al., 'Multiple deficiencies underlie NK cell inactivity in lymphotoxin-alpha gene-targeted mice', Journal of Immunology, 163, (3) pp. 1350-1353. ISSN 0022-1767 (1999) [Refereed Article]

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Citations: Web of Science - 37

1998Cook MC, Korner H, Riminton DS, Lemckert FA, Hasbold J, et al., 'Generation of splenic follicular structure and B cell movement in tumor necrosis factor-deficient mice', The Journal of Experimental Medicine, 188, (8) pp. 1503-1510 . ISSN 0022-1007 (1998) [Refereed Article]

DOI: 10.1084/jem.188.8.1503 [eCite] [Details]

Citations: Scopus - 44Web of Science - 40

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1998Hart PH, Grimbaldeston MA, Swift GJ, Sedgwick JD, Korner H, et al., 'TNF modulates susceptibility to UVB-induced systemic immunomodulation in mice by effects on dermal mast cell prevalence', European Journal of Immunology, 28, (9) pp. 2893-2901. ISSN 0014-2980 (1998) [Refereed Article]

DOI: 10.1002/(SICI)1521-4141(199809)28:09<2893::AID-IMMU2893>3.0.CO;2-U [eCite] [Details]

Citations: Web of Science - 30

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1998Hultgren O, Eugster HP, Sedgwick JD, Korner H, Tarkowski A, 'TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus', Journal of Immunology, 161, (11) pp. 5937-5942. ISSN 0022-1767 (1998) [Refereed Article]

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Citations: Web of Science - 77

1998Hunt NH, Medana IM, Sanni LA, Maitland D, Bloomfield G, et al., 'Immunopathology of murine cerebral malaria', Naunyn-Schmiedebergs Archives of Pharmacology, 358, (1) pp. R12. ISSN 0028-1298 (1998) [Letter or Note in Journal]

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1998Korner H, Cook M, Sedgwick JD, 'B cell movement in TNF-deficient mice: Evidence for an involvement of TNF-regulated chemokines in the formation of B cell follicles', Immunobiology: Experimental and Clinical, 199 pp. 395. ISSN 0171-2985 (1998) [Letter or Note in Journal]

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1998Riminton DS, Korner H, Strickland DH, Lemckert FA, Pollard JD, et al., 'Challenging cytokine redundancy: Inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice', The Journal of Experimental Medicine, 187, (9) pp. 1517-1528. ISSN 0022-1007 (1998) [Refereed Article]

DOI: 10.1084/jem.187.9.1517 [eCite] [Details]

Citations: Scopus - 140Web of Science - 107

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1998Smyth MJ, Kelly JM, Baxter AG, Korner H, Sedgwick JD, 'An Essential Role for Tumor Necrosis Factor in Natural Killer Cell-mediated Tumor Rejection in the Peritoneum', The Journal of Experimental Medicine, 188, (9) pp. 1611-1619. ISSN 0022-1007 (1998) [Refereed Article]

DOI: 10.1084/jem.188.9.1611 [eCite] [Details]

Citations: Scopus - 102Web of Science - 104

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1997Korner H, Cook M, Riminton DS, Lemckert FA, Hoek RM, et al., 'Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue', European Journal of Immunology, 27, (10) pp. 2600-2609. ISSN 0014-2980 (1997) [Refereed Article]

DOI: 10.1002/eji.1830271020 [eCite] [Details]

Citations: Scopus - 248Web of Science - 242

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1997Korner H, Lemckert FA, Chaudhri G, Etteldorf S, Sedgwick JD, 'Tumor necrosis factor blockade in actively induced experimental autoimmune encephalomyelitis prevents clinical disease despite activated T cell infiltration to the central nervous system', European Journal of Immunology, 27, (8) pp. 1973-1981. ISSN 0014-2980 (1997) [Refereed Article]

DOI: 10.1002/eji.1830270822 [eCite] [Details]

Citations: Scopus - 96Web of Science - 85

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1997Korner H, Riminton DS, Strickland DH, Lemckert FA, Pollard JD, et al., 'Critical points of tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targeting', The Journal of Experimental Medicine, 186, (9) pp. 1585-1590. ISSN 0022-1007 (1997) [Refereed Article]

DOI: 10.1084/jem.186.9.1585 [eCite] [Details]

Citations: Scopus - 197Web of Science - 184

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1997Korner H, Sedgwick JD, 'Implications of the targeted disruption of the genes for TNF and LT for B cell maturation and migration', Immunobiology: Experimental and Clinical, 198 pp. 233. ISSN 0171-2985 (1997) [Letter or Note in Journal]

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1997Lemckert FA, Sedgwick JD, Korner H, 'Gene targeting in C57BL/6 ES cells. Successful germ line transmission using recipient BALB/c blastocysts developmentally matured in vitro', Nucleic Acids Research, 25, (4) pp. 917-918 . ISSN 0305-1048 (1997) [Refereed Article]

DOI: 10.1093/nar/25.4.917 [eCite] [Details]

Citations: Scopus - 47Web of Science - 46

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1997Sedgwick JD, Korner H, Riminton DS, Strickland DH, Pollard JD, et al., 'Critical points of TNF action in the CNS inflammatory process defined in gene-targeted mice', Brain Pathology, 7, (4) pp. 1264. ISSN 1015-6305 (1997) [Letter or Note in Journal]

DOI: 10.1111/j.1750-3639.1997.tb01025.x [eCite] [Details]

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1996Dick AD, McMenamin PG, Korner H, Scallon BJ, Ghrayeb J, et al., 'Inhibition of tumor necrosis factor activity minimizes target organ damage in experimental autoimmune uveoretinitis despite quantitatively normal activated T cell traffic to the retina', European Journal of Immunology, 26, (5) pp. 1018-1025. ISSN 0014-2980 (1996) [Refereed Article]

DOI: 10.1002/eji.1830260510 [eCite] [Details]

Citations: Web of Science - 117

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1996Korner H, Sedgwick JD, 'Tumour necrosis factor and Lymphotoxin: Molecular aspects and role in tissue-specific autoimmunity', Immunology and Cell Biology, 74, (5) pp. 465-472. ISSN 0818-9641 (1996) [Refereed Article]

DOI: 10.1038/icb.1996.77 [eCite] [Details]

Citations: Scopus - 58Web of Science - 59

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1995Gallitaliadoros LA, Sedgwick JD, Wood SA, Korner H, 'Gene knock-out technology - a methodological overview for the interested novice ', Journal of Immunological Methods, 181, (1) pp. 1-15. ISSN 0022-1759 (1995) [Refereed Article]

DOI: 10.1016/0022-1759(95)00017-5 [eCite] [Details]

Citations: Scopus - 63Web of Science - 55

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1995Korner H, Goodsall AL, Lemckert FA, Scallon BJ, Ghrayeb J, et al., 'Unimpaired autoreactive T-cell traffic within the central nervous system during tumor necrosis factor receptor-mediated inhibition of experimental autoimmune encephalomyelitis', National Academy of Sciences of The United States of America. Proceedings, 92, (24) pp. 11066-11070. ISSN 0027-8424 (1995) [Refereed Article]

DOI: 10.1073/pnas.92.24.11066 [eCite] [Details]

Citations: Scopus - 54Web of Science - 52

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1994Korner H, Burgert HG, 'Down-Regulation of HLA Antigens by the Adenovirus Type-2 E3/19k Protein in a T-Lymphoma Cell-Line', Journal of Virology, 68, (3) pp. 1442-1448. ISSN 0022-538X (1994) [Refereed Article]

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Citations: Web of Science - 40

1994Korner H, Sedgwick JD, 'Prevention of experimental autoimmune encephalomyelitis (EAE) by TNF-R (p55)-huIgG: Mechanisms of action', European Cytokine Network, 2 pp. 211. ISSN 1148-5493 (1994) [Letter or Note in Journal]

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1993Korner H, Burgert HG, 'Adenovirus persistence in T-cells - Evidence for AD2 E3/19k-MHC class-I interaction', Journal of Leukocyte Biology, Supplement S pp. 131. ISSN 0741-5400 (1993) [Letter or Note in Journal]

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1993Wege H, Schliephake A, Korner H, Flory E, Wege H, 'An immunodominant CD4+ T cell site on the nucleocapsid protein of murine coronavirus contributes to protection against encephalomyelitis', Journal of General Virology, 74 pp. 1287-1294 . ISSN 0022-1317 (1993) [Refereed Article]

DOI: 10.1099/0022-1317-74-7-1287 [eCite] [Details]

Citations: Scopus - 20Web of Science - 19

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1993Wege H, Schliephake A, Korner H, Flory E, Wege H, 'Coronavirus-induced encephalomyelitis: an immunodominant CD4(+) T cell site on the nucleocapsid protein contributes to protection', Advances in Experimental Medicine and Biology, 342 pp. 413-418. ISSN 0065-2598 (1993) [Refereed Article]

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1992Korner H, Fritzsche U, Burgert HG, 'Tumor necrosis factor alpha stimulates expression of adenovirus early region 3 proteins: implications for viral persistence', National Academy of Sciences of The United States of America. Proceedings, 89, (24) pp. 11857-11861. ISSN 0027-8424 (1992) [Refereed Article]

DOI: 10.1073/pnas.89.24.11857 [eCite] [Details]

Citations: Scopus - 46Web of Science - 51

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1991Korner H, Schliephake A, Winter J, Zimprich F, Lassmann H, et al., 'Nucleocapsid or spike protein specific CD4+ T lymphocytes protect against coronavirus-induced encephalomyelitis in the absence of CD8+ T cells', Journal of Immunology, 147, (7) pp. 2317-2323. ISSN 0022-1767 (1991) [Refereed Article]

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Citations: Web of Science - 71

1990Mossner R, Sedgwick JD, Flory E, Korner H, Wege H, et al., 'Astrocytes as antigen presenting cells for primary and secondary T cell responses. Effect of astrocyte infection by murine hepatitis virus', Advances in Experimental Medicine and Biology, 276 pp. 647-654. ISSN 0065-2598 (1990) [Refereed Article]

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Citations: Web of Science - 4

1990Wege H, Winter J, Korner H, Flory E, Zimprich F, et al., 'Coronavirus induced demyelinating encephalomyelitis in rats: Immunopathological aspects of viral persistency', Advances in Experimental Medicine and Biology, 276 pp. 637-645. ISSN 0065-2598 (1990) [Refereed Article]

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Citations: Web of Science - 3

Chapter in Book

(1 outputs)
YearCitationAltmetrics
2016Korner H, Hu S, Bogdan C, 'Host-Parasite Interactions', Molecular Parasitology: Protozoan Parasites and their Molecules, Springer, J Walochnik & M Duchene (ed), Vienna, Austria, pp. 409-430. ISBN 978-3-7091-1415-5 (2016) [Research Book Chapter]

DOI: 10.1007/978-3-7091-1416-2_13 [eCite] [Details]

Co-authors: Hu S

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Review

(2 outputs)
YearCitationAltmetrics
2013Kling JC, Korner H, 'Different regulatory mechanisms in protozoan parasitic infections', International Journal for Parasitology, 43, (6) pp. 417-425. ISSN 0020-7519 (2013) [Substantial Review]

DOI: 10.1016/j.ijpara.2013.02.001 [eCite] [Details]

Citations: Scopus - 8Web of Science - 9

Co-authors: Kling JC

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2013Lee AYS, Eri RD, Lyons AB, Grimm MC, Korner H, 'CC chemokine ligand 20 and its cognate receptor CCR6 in mucosal T cell immunology and inflammatory bowel disease: odd couple or axis of evil?', Frontiers in Immunology, 4, (194) pp. 1-7. ISSN 1664-3224 (2013) [Substantial Review]

DOI: 10.3389/fimmu.2013.00194 [eCite] [Details]

Citations: Scopus - 46Web of Science - 48

Co-authors: Lee AYS; Eri RD; Lyons AB

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Conference Publication

(1 outputs)
YearCitationAltmetrics
2011Korner H, 'Meeting of the Australian Flow Cytometry Group', 34th Annual Meeting of the Australasian Flow Cytometry Group, August, Hobart, Australia (2011) [Chair National Conference]

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Grants & Funding

Prof Korner's work has been supported by funding through the NHMRC in addition to a number of different smaller grants from a broad range of sources. In 2011 he has been successful to receive a Ramaciotti equipment grant for the purchase of an analytical 9-colour flow cytometer (Cyan, Beckman Coulter) and a Miltenyi AutoMax. He has been appointed as one of 5 New Star Professors at the University of Tasmania. This position is fully covered by a central grant of the University of Tasmania until the end of 2015.

Funding Summary

Number of grants

10

Total funding

$1,375,297

Projects

Is Vitamin D really involved in MS? (2016)$14,000
Description
This proposed pilot study will allow us to generate data sets that bring genetic polymorphisms and biological outcome into a context. These data from a small number of MS patients and controls will enable us to perform a power analysis that will be the foundation of a future project grant application.
Funding
Multiple Sclerosis Research Australia ($14,000)
Scheme
Grant-Incubator
Administered By
University of Tasmania
Research Team
Korner H
Year
2016
Functional consequences of Multiple Sclerosis-associated genetic changes in Vitamin D metabolism genes in T cells and the pathogenesis of autoimmunity (2014 - 2015)$24,950
Description
It is now well recognised that the risk of developing Multiple Sclerosis (MS) is governed by a complex interplay between genetic and environmental factors. Genes within the vitamin D pathway have been implicated in MS risk as has lower levels of vitamin D. How these 2 factors interact to alter immunity and increase the risk of developing autoimmune disease is not clear. This project looks at the functional consequences of a change in the genetic code in known MS risk genes that are in the vitamin D metabolic pathway and how these changes alter the function of T lymphocytes, the immune cells thought to play a major role in the inflammation that is characteristic of MS.
Funding
Multiple Sclerosis Research Australia ($24,950)
Scheme
Grant-Incubator
Administered By
University of Tasmania
Research Team
Korner H; Taylor BVM
Period
2014 - 2015
Human SLE: Searching new biomarkers and potential targets for therapy (2013)$35,000
Funding
The Lupus Association of Tasmania ($35,000)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Korner H; Adams MJ
Year
2013
Do adaptive regulatory cells or activated T cells dominate in cystic fibrosis? (2012)$8,228
Funding
Royal Hobart Hospital Research Foundation ($8,228)
Scheme
Grant-Starter
Administered By
University of Tasmania
Research Team
Beggs S; Cooley MA; Roddam LF; Korner H; Stock D
Year
2012
The biological role of CCR6 - CCL20 chemokine axis in humoral immunity (2012)$8,200
Funding
The Select Foundation ($8,200)
Scheme
Grant-Small Grants Scheme
Administered By
University of Tasmania
Research Team
Bannan J; Korner H
Year
2012
Epigenetic regulation of T-cell gene expression programs (2012)$8,505
Funding
The Select Foundation ($8,505)
Scheme
Grant-Small Grants Scheme
Administered By
University of Tasmania
Research Team
Holloway AF; Korner H
Year
2012
Reversible and irreversible TNF-mediated cognitive decline (2011 - 2013)$429,208
Funding
National Health & Medical Research Council ($429,208)
Scheme
Grant-Project
Administered By
University of Adelaide
Research Team
Baune B; Korner H; Anscomb H
Period
2011 - 2013
Grant Reference
1003788
Absence of CC chemokine receptor 6 dysregulates the humoral immune response (2011 - 2013)$506,706
Funding
National Health & Medical Research Council ($506,706)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Korner H
Period
2011 - 2013
Grant Reference
1004592
Upgrade of the flow cytometry facility of the Menzies Research Institute with a multi-parameter analytical flow cytometer CyAn ADP 9 Color for key applications (2011)$75,000
Funding
Clive & Vera Ramaciotti Foundation ($75,000)
Scheme
Grant-Equipment
Administered By
University of Tasmania
Research Team
Korner H; McMorran BJ; Woods GM; Holloway AF; West AK
Year
2011
Modulation of leishmaniasis by the proinflammatory cytokines TNF (2008 - 2010)$265,500
Funding
National Health & Medical Research Council ($265,500)
Scheme
Grant-Project
Administered By
National Health & Medical Research Council
Research Team
Korner H
Period
2008 - 2010
Grant Reference
485807

Research Supervision

Prof Korner has successfully supervised a number of PhD and Honours students to completion.

Current

1

Completed

6

Current

DegreeTitleCommenced
PhDIdentifying the Role of Inflammatory Circuit in Establishing and Pathogenesis of Colon Cancer2018

Completed

DegreeTitleCompleted
PhDNew Evidence for an Association between Immune Cells, Vitamin D and MS Risk SNPs
Candidate: Ming Lu
2019
PhDRole of TNF in the Regulation of the Innate Immune Response in Leishmaniasis
Candidate: Shanshan Hu
2018
PhDRedefining the Role of Tumour Necrosis Factor in Macrophage Differentiation and Effector Function in Bacterial and Tumour Defences
Candidate: Xinying Li
2018
PhDGenetic Ablation of CCR6 Confers Differential Exacerbation in a Spontaneous Colitis Model
Candidate: Waheedha Fathima Basheer
2017
PhDInvestigation of Neoplastic Transition of the Colonic Epithelium in the Winnie Mouse Model of Chronic Colitis
Candidate: Sarron Yael Randall-Demllo
2017
PhDThe Role of the CC-Chemokine Receptor 6, CCR6, in B Cell Differentiation During the Humoral Immune Response
Candidate: Jennifer Bannan
2015