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Laura Laslett

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Laura Laslett

NHMRC Early Career Fellow
Menzies Institute for Medical Research

Room 356-02, Medical Science 2, Hobart CBD Campuses

+61 3 6226 7736 (phone)

+61 3 6226 7704 (fax)

Laura.Laslett@utas.edu.au

Dr Laura Laslett is a musculoskeletal epidemiologist and NHMRC Early Career Fellow at the Menzies Institute for Medical Research. Her research focuses on osteoarthritic pain.

Biography

Dr Laslett moved to Hobart in 2009 to complete a PhD on determinants, correlates, modifiers of musculoskeletal pain at the Menzies Institute for Medical Research, University of Tasmania.  She commenced postdoctoral work in 2013 as an Arthritis Australia Heald Fellow, and then as an NHMRC Early Career Fellow in 2014.

Prior to moving to Hobart, Laura worked as a research officer at the Discipline of Medicine at The University of Adelaide (Modbury Hospital) for 6 years, and as an epidemiologist for SA Health for 2 years.  She also completed a 3 month placement at the Division of Rheumatic and Musculoskeletal Disease at the University of Leeds (Leeds UK) in 2012, funded by an Osteoarthritis Research Society International Young Investigator Scholarship. She has worked with several research groups (Adelaide, Hobart and Leeds (UK)) and has expertise in the conduct and analysis of intervention studies, including 4 clinical trials and an educational intervention for osteoporosis.

Career summary

Qualifications

  • PhD, University of Tasmania, Australia, 2013. Determinants, correlates and modifiers of musculoskeletal pain
  • MMedScience, The University of Adelaide, Australia, 2003. Screening for low bone mineral density in patients with respiratory disease
  • Grad Dip Public Health, The University of Adelaide, Australia, 2014
  • BSc (Hons), The University of Adelaide, Australia, 1999. Epidemiological Risk Factors for Unexplained Fetal Death
  • BSc, The University of Adelaide, Australia, 1998

Memberships

Professional practice

  • Osteoarthritis Research Society International
  • Public Health Association of Australia
  • Australasian Epidemiology Association
  • Australia and New Zealand Bone and Mineral Society

Administrative expertise

  • Management of clinical trials.  Writing of study protocols and research-related clinical trial administration eg NEAF, CTN forms
  • Use of the Teleform system to assist in data collection for participant-based trials

Teaching

Principles of epidemiology, Bias and confounding, Musculoskeletal pain, Musculoskeletal health

Teaching expertise

I teach epidemiological principles, and epidemiological methods, including bias and confounding at both undergraduate and graduate level.

Teaching responsibility

I contribute to teaching in CEA200 (Population Health) and CEA501 (Introduction to Epidemiology) as well as epidemiology short courses.

Research Appointments

  • Dr Laslett is a Branch Officer for the Tasmanian Branch of the Public Health Association of Australia

View more on Dr Laura Laslett in WARP

Expertise

  • Knee pain
  • Back pain
  • Osteoporosis
  • Osteoarthritis
  • Musculokeletal pain, arthritic pain
  • Musculoskeletal health
  • Clinical trials for musculoskeletal pain

Research Themes

Despite the large impact of osteoarthritis on the community there are currently no treatments that are approved to change the disease course, and current treatments focus on reducing pain and improving function – the major symptoms of osteoarthritis. However, there is a significant gap between the level of pain relief patients want, and what they actually get from treatments available today.

Dr Laslett's research has focussed on targeting OA treatments to people with OA with different sources of pain. One study from Dr Laslett's PhD demonstrated the first proof of principle for using an osteoporosis drug and demonstrating that it had effects in a key structural feature of OA (bone marrow lesions), and reduced knee pain in people with knee OA (ZAP1 trial). A second study from her PhD demonstrated that a natural therapy was effective in reducing pain in people with knee OA.

She is currently running the Modic trial, in people with a similar structural feature to bone marrow lesions (Modic changes), and back pain. This study is testing two different osteoporosis treatments to assess whether they are effective in reducing back pain and Modic changes. She is currently involved with several other clinical trials for treating pain in the knees and hands. 

Dr Laslett's research aligns to the University's research theme of Better Health. Her research interests include understanding sources of pain in osteoarthritis, and testing interventions that have the potential to treat musculoskeletal pain, and to change disease course of osteoarthritis and other musculoskeletal conditions.

Dr Laslett is also involved in the analysis of observational data to answer important clinical questions on pain and how it might be treated. She is working with Sarah Mattap (Honours student) to determine whether pathological changes at the tibial enthesis is associated with pain and other structural factors normally associated with knee pain. She collaborates with colleagues at the University of Leeds on analysis of data from a large US-based cohort to assess links between lower limb and upper limb pain, and collaborates with researchers at La Trobe University on non-structural factors associated with existing and new foot pain.

Collaboration

Laura currently collaborates with researchers at the University of Leeds and imorphics (Manchester). This work involves assessing predictors of newly painful joints, and assessing the effect of treatment with bone active medication changes the shape of knee joints.

She also collaborates with researchers at Monash University, Sydney University, the Queen Elizabeth Hospital, and the University of Western Australia on clinical trials in knee pain; and with researchers at La Trobe University on factors associated with foot pain.

Awards

  • Menzies Research Institute Tasmania Postgraduate student award (AUD$2000), 2012
  • OARSI Young Investigator Scholarship to go to Leeds, UK for 3 months (US$6500), 2012
  • Poster prize:  Best poster and best poster defence at the Sharing Excellence in Research Conference (UTAS Graduate Research), Hobart (AUD$1000), 2011
  • Young Investigator Award, OARSI imaging conference (Salzburg, Austria) (€700), 2011
  • Abstract Prize:  Best abstract, Osteoarthritis section, European League against Rheumatism (EULAR) conference, London (€1000), 2011
  • Poster Prize: Best Clinical Poster at the Australian Rheumatology Association conference (Melbourne) (AUD$500), 2010
  • Poster Prize:  Best poster in the Rheumatology Health Professionals section at the Australian Rheumatology Association conference (Adelaide) (AUD$500), 2008

Current projects

  • Modic trial
  • HUMOR trial
  • ZAP2 trial
  • Osteoarthritis of the Knee Statin (OAKS) Study
  • Knee pain predicts new shoulder pain and associations are mediated by weakness. Data analysis from the Osteoarthritis Initiative
  • Do ligament and enthesis abnormalities predict pain? An MRI investigation of the role of enthesis abnormalities in patellofemoral pain, using data from the TASOAC study.Non-structural correlates of foot pain: data analysis from the TASOAC study

Fields of Research

  • Rheumatology and Arthritis (110322)
  • Clinical Sciences (110399)
  • Nutritional Physiology (111103)
  • Geriatrics and Gerontology (110308)
  • Epidemiology (111706)
  • Radiology and Organ Imaging (110320)
  • Orthopaedics (110314)
  • Aged Health Care (111702)
  • Education Assessment and Evaluation (130303)
  • Peripheral Nervous System (110905)
  • Oral Medicine and Pathology (110505)
  • Biomedical Instrumentation (090303)
  • Sports Medicine (110604)
  • Cellular Immunology (110704)
  • Primary Health Care (111717)

Research Objectives

  • Skeletal System and Disorders (incl. Arthritis) (920116)
  • Health Related to Ageing (920502)
  • Allied Health Therapies (excl. Mental Health Services) (920201)
  • Disability and Functional Capacity (920403)
  • Health (929999)
  • Women's Health (920507)
  • Health Status (e.g. Indicators of Well-Being) (920408)
  • Evaluation of Health Outcomes (920204)
  • Nervous System and Disorders (920111)
  • Dental Health (920402)
  • Education and Training Systems Policies and Development (930501)

Publications

Dr Laslett has published over 30 peer review publications, primarily in osteoarthritis epidemiology, knee pain, and clinical trials treating osteoarthritis pain. Two of her publications are in theLancet (IF 38.2) and sevenin the top Rheumatology journal Annals of the Rheumatic Diseases (IF 9.1).

Total publications

56

Highlighted publications

(1 outputs)
YearTypeCitationAltmetrics
2012Journal ArticleLaslett LL, Dore DA, Quinn SJ, Boon P, Ryan E, et al., 'Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial', Annals of the Rheumatic Diseases, 71, (8) pp. 1322-1328. ISSN 0003-4967 (2012) [Refereed Article]

DOI: 10.1136/annrheumdis-2011-200970 [eCite] [Details]

Citations: Scopus - 144Web of Science - 128

Co-authors: Dore DA; Boon P; Winzenberg TM; Jones G

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Journal Article

(55 outputs)
YearCitationAltmetrics
2018Aitken D, Laslett LL, Cai G, Hill C, March L, et al., 'A protocol for a multicentre, randomised, double-blind, placebo-controlled trial to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change and knee pain over 24 months in knee osteoarthritis patients - ZAP2', BMC Musculoskeletal Disorders, 19, (1) Article 217. ISSN 1471-2474 (2018) [Refereed Article]

DOI: 10.1186/s12891-018-2143-2 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Aitken D; Blizzard L; Jones G

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2018Aitken D, Laslett LL, Pan F, Haugen IK, Otahal P, et al., 'A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis - the HUMOR trial', Osteoarthritis and Cartilage, 26, (7) pp. 880-887. ISSN 1063-4584 (2018) [Refereed Article]

DOI: 10.1016/j.joca.2018.02.899 [eCite] [Details]

Citations: Scopus - 9

Co-authors: Aitken D; Pan F; Otahal P; Jones G

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2018Laslett LL, Menz HB, Otahal P, Pan F, Cicuttini FM, et al., 'Factors associated with prevalent and incident foot pain: data from the Tasmanian Older Adult Cohort Study', Maturitas, 118 pp. 38-43. ISSN 0378-5122 (2018) [Refereed Article]

DOI: 10.1016/j.maturitas.2018.10.004 [eCite] [Details]

Co-authors: Otahal P; Pan F; Jones G

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2018Mattap SM, Aitken D, Wills K, Halliday A, Ding C, et al., 'Patellar tendon enthesis abnormalities and their association with knee pain and structural abnormalities in older adults', Osteoarthritis and Cartilage, 27, (3) pp. 449-458. ISSN 1063-4584 (2018) [Refereed Article]

DOI: 10.1016/j.joca.2018.11.009 [eCite] [Details]

Citations: Scopus - 1

Co-authors: Mattap SM; Aitken D; Wills K; Ding C; Han W; Munugoda I; Jones G

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2018Mattap SM, Aitken D, Wills K, Laslett L, Ding C, et al., 'How do MRI-detected subchondral bone marrow lesions (BMLs) on two different MRI sequences correlate with clinically important outcomes?', Calcified Tissue International, 103, (2) pp. 131-143. ISSN 0171-967X (2018) [Refereed Article]

DOI: 10.1007/s00223-018-0402-8 [eCite] [Details]

Citations: Web of Science - 14

Co-authors: Mattap SM; Aitken D; Wills K; Ding C; Jones G

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2018Meng T, Thayer S, Venn A, Wu F, Cicuttini F, et al., 'Association of childhood adiposity measures with adulthood knee cartilage defects and bone marrow lesions: a 25-year cohort study', Osteoarthritis and Cartilage, 26, (8) pp. 1055-1062. ISSN 1063-4584 (2018) [Refereed Article]

DOI: 10.1016/j.joca.2018.05.008 [eCite] [Details]

Co-authors: Venn A; Wu F; Dwyer T; Jones G; Ding C; Antony B

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2018Meng T, Venn A, Eckstein F, Wirth W, Cicuttini F, et al., 'Association of adiposity measures in childhood and adulthood with knee cartilage thickness, volume and bone area in young adults', International Journal of Obesity pp. 1-11. ISSN 0307-0565 (2018) [Refereed Article]

DOI: 10.1038/s41366-018-0234-7 [eCite] [Details]

Citations: Web of Science - 8

Co-authors: Venn A; Dwyer T; Jones G; Ding C; Antony B

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2018Tatangelo G, Watts J, Lim K, Connaughton C, Abimanyi-Ochom J, et al., 'The cost of osteoporosis, osteopenia, and associated fractures in Australia in 2017', Journal of Bone and Mineral Research pp. 1-10. ISSN 0884-0431 (2018) [Refereed Article]

DOI: 10.1002/jbmr.3640 [eCite] [Details]

Citations: Web of Science - 1

Co-authors: Winzenberg T

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2018Wu F, Wills K, Laslett LL, Riley MD, Oldenburg B, et al., 'Individualized fracture risk feedback and long-term benefits after 10 years', American Journal of Preventive Medicine, 54, (2) pp. 266-274. ISSN 0749-3797 (2018) [Refereed Article]

DOI: 10.1016/j.amepre.2017.10.018 [eCite] [Details]

Co-authors: Wu F; Wills K; Jones G; Winzenberg T

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2018Cai G, Laslett LL, Aitken D, Halliday A, Pan F, et al., 'Effect of Zoledronic Acid and Denosumab in patients with low back pain and modic change: A proof-of-principle trial', Journal of Bone and Mineral Research, 33, (5) pp. 773-782. ISSN 0884-0431 (2018) [Refereed Article]

DOI: 10.1002/jbmr.3376 [eCite] [Details]

Citations: Scopus - 2

Co-authors: Aitken D; Pan F; Otahal P; Winzenberg TM; Jones G

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2017Pan F, Laslett L, Blizzard L, Cicuttini F, Winzenberg T, et al., 'Associations between fat mass and multi-site pain: A 5-year longitudinal study', Arthritis Care & Research, 69, (4) pp. 509-516. ISSN 2151-464X (2017) [Refereed Article]

DOI: 10.1002/acr.22963 [eCite] [Details]

Citations: Scopus - 9Web of Science - 10

Co-authors: Pan F; Blizzard L; Winzenberg T; Ding C; Jones G

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2017Warner SC, Walsh DA, Laslett LL, Maciewicz RA, Soni A, et al., 'Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene', European Journal of Pain, 21, (7) pp. 1277-1284. ISSN 1090-3801 (2017) [Refereed Article]

DOI: 10.1002/ejp.1027 [eCite] [Details]

Citations: Scopus - 10Web of Science - 9

Co-authors: Jones G

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2017Wu F, Callisaya M, Wills K, Laslett LL, Jones G, et al., 'Both baseline and change in lower limb muscle strength in younger women are independent predictors of balance in middle age: A 12-Year population-based prospective study', Journal of Bone and Mineral Research, 32, (6) pp. 1201-1208. ISSN 0884-0431 (2017) [Refereed Article]

DOI: 10.1002/jbmr.3103 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Wu F; Callisaya M; Wills K; Jones G; Winzenberg T

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2017Wu F, Wills K, Laslett LL, Oldenburg B, Jones G, et al., 'Moderate-to-vigorous physical activity but not sedentary time is associated with musculoskeletal health outcomes in a cohort of Australian middle-aged women', Journal of Bone and Mineral Research, 32, (4) pp. 708-715. ISSN 0884-0431 (2017) [Refereed Article]

DOI: 10.1002/jbmr.3028 [eCite] [Details]

Citations: Scopus - 11Web of Science - 10

Co-authors: Wu F; Wills K; Jones G; Winzenberg T

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2017Wu F, Wills K, Laslett LL, Oldenburg B, Jones G, et al., 'Associations of dietary patterns with bone mass, muscle strength and balance in a cohort of Australian middle-aged women', British Journal of Nutrition, 118, (8) pp. 598-606. ISSN 0007-1145 (2017) [Refereed Article]

DOI: 10.1017/S0007114517002483 [eCite] [Details]

Citations: Scopus - 4Web of Science - 3

Co-authors: Wu F; Wills K; Jones G; Winzenberg T

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2017Wu F, Wills K, Laslett LL, Oldenburg B, Seibel MJ, et al., 'Cut-points for associations between vitamin D status and multiple musculoskeletal outcomes in middle-aged women', Osteoporosis International, 28, (2) pp. 505-515. ISSN 0937-941X (2017) [Refereed Article]

DOI: 10.1007/s00198-016-3754-9 [eCite] [Details]

Citations: Scopus - 8Web of Science - 4

Co-authors: Wu F; Wills K; Jones G; Winzenberg T

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2017Zhu Z, Laslett LL, Han W, Antony B, Pan F, et al., 'Associations between MRI-detected early osteophytes and knee structure in older adults: a population-based cohort study', Osteoarthritis and Cartilage, 25, (12) pp. 2055-2062. ISSN 1063-4584 (2017) [Refereed Article]

DOI: 10.1016/j.joca.2017.09.005 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Zhu Z; Han W; Antony B; Pan F; Jones G; Ding C

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2017Zhu Z, Laslett LL, Jin X, Han W, Antony B, et al., 'Association between MRI-detected osteophytes and changes in knee structures and pain in older adults: a cohort study', Osteoarthritis and Cartilage, 25, (7) pp. 1084-1092. ISSN 1063-4584 (2017) [Refereed Article]

DOI: 10.1016/j.joca.2017.01.007 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Zhu Z; Jin X; Han W; Antony B; Lu M; Jones G; Ding C

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2017Zhu Z, Otahal P, Wang B, Jin X, Laslett LL, et al., 'Cross-sectional and longitudinal associations between serum inflammatory cytokines and knee bone marrow lesions in patients with knee osteoarthritis', Osteoarthritis and Cartilage, 25, (4) pp. 499-505. ISSN 1063-4584 (2017) [Refereed Article]

DOI: 10.1016/j.joca.2016.10.024 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Zhu Z; Otahal P; Jin X; Antony B; Han W; Winzenberg TM; Jones G; Ding C

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2017Pan F, Laslett L, Tian J, Cicuttini F, Winzenberg T, et al., 'Association Between Pain at Sites Outside the Knee and Knee Cartilage Volume Loss in Elderly People Without Knee Osteoarthritis: A Prospective Study', Arthritis Care & Research, 69, (5) pp. 659-666. ISSN 2151-464X (2017) [Refereed Article]

DOI: 10.1002/acr.22964 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Pan F; Tian J; Winzenberg T; Ding C; Jones G

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2016Hall J, Laslett LL, Martel-Pelletier J, Pelletier JP, Abram F, et al., 'Change in knee structure and change in tibiofemoral joint space width: a five year longitudinal population-based study', BMC Musculoskeletal Disorders, 17 Article 25. ISSN 1471-2474 (2016) [Refereed Article]

DOI: 10.1186/s12891-016-0879-0 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Hall J; Ding CH; Jones G

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2016Jin X, Ding C, Wang X, Antony B, Laslett LL, et al., 'Longitudinal associations between adiposity and change in knee pain: Tasmanian older adult cohort study', Seminars in Arthritis and Rheumatism, 45, (5) pp. 564-569. ISSN 0049-0172 (2016) [Refereed Article]

DOI: 10.1016/j.semarthrit.2015.10.006 [eCite] [Details]

Citations: Scopus - 7Web of Science - 6

Co-authors: Jin X; Ding C; Antony B; Blizzard L; Jones G

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2016Laslett LL, Otahal P, Hensor EMA, Kingsbury SR, Conaghan PG, 'Knee pain predicts subsequent shoulder pain and the association is mediated by leg weakness: Longitudinal observational data from the osteoarthritis initiative', Journal of Rheumatology, 43, (11) pp. 2049-2055. ISSN 0315-162X (2016) [Refereed Article]

DOI: 10.3899/jrheum.160001 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Otahal P

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2016Laslett LL, Pelletier J-P, Cicuttini FM, Jones G, Martel-Pelletier J, 'Measuring Disease Progression in Osteoarthritis', Current Treatment Options in Rheumatology, 2, (2) pp. 97-110. ISSN 2198-6002 (2016) [Refereed Article]

DOI: 10.1007/s40674-016-0041-z [eCite] [Details]

Co-authors: Jones G

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2016Rogers JA, Wilson A, Laslett LL, Winzenberg TM, 'Physical interventions (orthoses, splints, exercise and manual therapy) for treating plantar heel pain', Cochrane Database of Systematic Reviews, 2016, (8) Article CD012304. ISSN 1469-493X (2016) [Refereed Article]

DOI: 10.1002/14651858.CD012304 [eCite] [Details]

Co-authors: Rogers JA; Wilson A; Winzenberg TM

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2016Scott D, Chandrasekara SD, Laslett LL, Cicuttini F, Ebeling PR, et al., 'Associations of Sarcopenic Obesity and Dynapenic Obesity with Bone Mineral Density and Incident Fractures Over 5-10 Years in Community-Dwelling Older Adults', Calcified Tissue International, 99, (1) pp. 30-42. ISSN 0171-967X (2016) [Refereed Article]

DOI: 10.1007/s00223-016-0123-9 [eCite] [Details]

Citations: Scopus - 24Web of Science - 22

Co-authors: Jones G

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2016Wu F, Callisaya M, Laslett LL, Wills K, Zhou Y, et al., 'Lower limb muscle strength is associated with poor balance in middle-aged women: linear and nonlinear analyses', Osteoporosis International, 27, (7) pp. 2241-2248. ISSN 0937-941X (2016) [Refereed Article]

DOI: 10.1007/s00198-016-3545-3 [eCite] [Details]

Citations: Scopus - 6Web of Science - 5

Co-authors: Wu F; Callisaya M; Wills K; Zhou Y; Jones G; Winzenberg T

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2016Zhu Z, Ding C, Jin X, Eathakkattu Antony BS, Han W, et al., 'Patellofemoral bone marrow lesions: natural history and associations with pain and structure', Arthritis Care & Research, 68, (11) pp. 1647-1654. ISSN 2151-464X (2016) [Refereed Article]

DOI: 10.1002/acr.22871 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Zhu Z; Ding C; Jin X; Eathakkattu Antony BS; Han W; Jones G

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2016Zhu Z, Jin X, Wang B, Wluka A, Antony B, et al., 'Cross-sectional and longitudinal associations between serum levels of high-sensitivity C-reactive protein, knee bone marrow lesions, and knee pain in patients with knee osteoarthritis', Arthritis Care & Research, 68, (10) pp. 1471-1477. ISSN 2151-464X (2016) [Refereed Article]

DOI: 10.1002/acr.22834 [eCite] [Details]

Citations: Scopus - 5Web of Science - 7

Co-authors: Zhu Z; Jin X; Antony B; Winzenberg T; Jones G; Ding C

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2015Abimanyi-Ochom J, Watts JJ, Borgstrom F, Nicholson GC, Shore-Lorenti C, et al., 'Changes in quality of life associated with fragility fractures: Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS)', Osteoporosis International, 26, (6) pp. 1-10. ISSN 0937-941X (2015) [Refereed Article]

DOI: 10.1007/s00198-015-3088-z [eCite] [Details]

Citations: Scopus - 25Web of Science - 21

Co-authors: Winzenberg T

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2015Cai J, Xu J, Wang K, Zheng S, He F, et al., 'Association between infrapatellar fat pad volume and knee structural changes in patients with knee osteoarthritis', Journal of Rheumatology, 42, (10) pp. 1878-1884. ISSN 0315-162X (2015) [Refereed Article]

DOI: 10.3899/jrheum.150175 [eCite] [Details]

Citations: Scopus - 33Web of Science - 31

Co-authors: Ding C

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2015Wu F, Laslett LL, Zhang Q, 'Threshold effects of vitamin D status on bone health in Chinese adolescents with low calcium intake', Journal of Clinical Endocrinology and Metabolism, 100, (12) pp. 4481-4489. ISSN 1945-7197 (2015) [Refereed Article]

DOI: 10.1210/jc.2015-2849 [eCite] [Details]

Citations: Scopus - 5Web of Science - 3

Co-authors: Wu F

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2015Laslett LL, Jin X, Jones G, 'Efficacy and safety of plant-derived products for the treatment of osteoarthritis', Botanics: Targets and Therapy, 5 pp. 1-20. ISSN 1179-9897 (2015) [Refereed Article]

DOI: 10.2147/BTAT.S33431 [eCite] [Details]

Co-authors: Jin X; Jones G

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2014Jones G, Winzenberg TM, Callisaya ML, Laslett LL, 'Lifestyle modifications to improve musculoskeletal and bone health and reduce disability - A life-course approach', Best Practice & Research: Clinical Rheumatology, 28, (3) pp. 461-478. ISSN 1532-1770 (2014) [Refereed Article]

DOI: 10.1016/j.berh.2014.07.004 [eCite] [Details]

Citations: Scopus - 4Web of Science - 6

Co-authors: Jones G; Winzenberg TM; Callisaya ML

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2014Laslett LL, Kingsbury SR, Hensor EMA, Bowes MA, Conaghan PG, 'Effect of bisphosphonate use in patients with symptomatic and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative', Annals of the Rheumatic Diseases, 73, (5) pp. 824-830. ISSN 1468-2060 (2014) [Refereed Article]

DOI: 10.1136/annrheumdis-2012-202989 [eCite] [Details]

Citations: Scopus - 37Web of Science - 30

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2014Cross M, Smith E, Hoy D, Nolte S, Ackerman I, et al., 'The global burden of hip and knee osteoarthritis: Estimates from the Global Burden of Disease 2010 study', Annals of the Rheumatic Diseases, 73, (7) pp. 1323-1330. ISSN 0003-4967 (2014) [Refereed Article]

DOI: 10.1136/annrheumdis-2013-204763 [eCite] [Details]

Citations: Scopus - 804Web of Science - 743

Co-authors: Jones G

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2014Liu S, Liu L, Wu S, Yang T, Pan F, et al., 'Lack of Association Between TESPA1 Gene Polymorphisms (rs1801876, rs2171497, rs4758994, and rs997173) and Ankylosing Spondylitis in a Chinese Population', Inflammation, 37, (6) pp. 2040-2046. ISSN 0360-3997 (2014) [Refereed Article]

DOI: 10.1007/s10753-014-9936-8 [eCite] [Details]

Citations: Scopus - 1

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2014Neogi T, Soni A, Doherty SA, Laslett LL, Maciewicz RA, et al., 'Contribution of the COMT Val158Met variant to symptomatic knee osteoarthritis', Annals of the Rheumatic Diseases: The Euler Journal, 73, (1) pp. 315-317. ISSN 1468-2060 (2014) [Refereed Article]

DOI: 10.1136/annrheumdis-2013-203836 [eCite] [Details]

Citations: Scopus - 11Web of Science - 10

Co-authors: Jones G

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2014Wu F, Laslett LL, Wills K, Oldenburg B, Jones G, et al., 'Effects of Individualized Bone Density Feedback and Educational Interventions on Osteoporosis Knowledge and Self-Efficacy: A 12-Yr Prospective Study', Journal of Clinical Densitometry, 17, (4) pp. 466-472. ISSN 1094-6950 (2014) [Refereed Article]

DOI: 10.1016/j.jocd.2014.07.008 [eCite] [Details]

Citations: Scopus - 16Web of Science - 17

Co-authors: Wu F; Wills K; Jones G; Winzenberg T

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2014Laslett LL, Quinn S, Burgess JR, Parameswaran V, Winzenberg TM, et al., 'Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study', Annals of the Rheumatic Diseases, 73, (4) pp. 697-703. ISSN 1468-2060 (2014) [Refereed Article]

DOI: 10.1136/annrheumdis-2012-202831 [eCite] [Details]

Citations: Scopus - 44Web of Science - 38

Co-authors: Burgess JR; Winzenberg TM; Jones G; Ding C

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2013Panoutsopoulou K, Metrustry S, Doherty SA, Laslett LL, Maciewicz RA, et al., 'The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study', Annals of the Rheumatic Diseases, 73, (12) pp. 2082-2086. ISSN 1468-2060 (2013) [Refereed Article]

DOI: 10.1136/annrheumdis-2013-203772 [eCite] [Details]

Citations: Scopus - 18Web of Science - 18

Co-authors: Jones G

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2012Crisp A, Dixon T, Jones G, Cumming RG, Laslett LL, et al., 'Declining incidence of osteoporotic hip fracture in Australia', Archives of Osteoporosis, 7, (1-2) pp. 179-185. ISSN 1862-3522 (2012) [Refereed Article]

DOI: 10.1007/s11657-012-0095-y [eCite] [Details]

Citations: Scopus - 22

Co-authors: Jones G

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2012Laslett LL, Dore DA, Quinn SJ, Boon P, Ryan E, et al., 'Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial', Annals of the Rheumatic Diseases, 71, (8) pp. 1322-1328. ISSN 0003-4967 (2012) [Refereed Article]

DOI: 10.1136/annrheumdis-2011-200970 [eCite] [Details]

Citations: Scopus - 144Web of Science - 128

Co-authors: Dore DA; Boon P; Winzenberg TM; Jones G

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2012Laslett LL, Just SJ, Quinn SJ, Winzenberg TM, Jones G, 'Excess body fat is associated with higher risk of vertebral deformities in older women but not in men: a cross-sectional study', Osteoporosis International, 23, (1) pp. 67-74. ISSN 1433-2965 (2012) [Refereed Article]

DOI: 10.1007/s00198-011-1741-8 [eCite] [Details]

Citations: Scopus - 39Web of Science - 35

Co-authors: Just SJ; Winzenberg TM; Jones G

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2012Laslett LL, Quinn SJ, Darian-Smith E, Kwok M, Fedorova T, et al., 'Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised controlled trial', Osteoarthritis and Cartilage: Journal of The Osteoarthritis Research Society International, 20, (11) pp. 1209-1216. ISSN 1063-4584 (2012) [Refereed Article]

DOI: 10.1016/j.joca.2012.07.019 [eCite] [Details]

Citations: Scopus - 10Web of Science - 10

Co-authors: Darian-Smith E; Korner H; Jones G

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2012Laslett LL, Quinn SJ, Winzenberg TM, Sanderson K, Cicuttini F, et al., 'A prospective study of the impact of musculoskeletal pain and radiographic osteoarthritis on health related quality of life in community dwelling older people', BMC Musculoskeletal Disorders, 13 Article 168. ISSN 1471-2474 (2012) [Refereed Article]

DOI: 10.1186/1471-2474-13-168 [eCite] [Details]

Citations: Scopus - 35Web of Science - 30

Co-authors: Quinn SJ; Winzenberg TM; Sanderson K; Jones G

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2012Murray CJL, Vos T, Lozano R, Naghavi M, Flaxman AD, et al., 'Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010', Lancet, 380, (9859) pp. 2197-2223. ISSN 0140-6736 (2012) [Refereed Article]

DOI: 10.1016/S0140-6736(12)61689-4 [eCite] [Details]

Citations: Scopus - 4504Web of Science - 4299

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2012Redmond CL, Bain GI, Laslett LL, McNeil JD, 'Deteriorating tactile sensation in patients with hand syndromes associated with diabetes: a two-year observational study', Journal of Diabetes and Its Complications, 26, (4) pp. 313-318. ISSN 1056-8727 (2012) [Refereed Article]

DOI: 10.1016/j.jdiacomp.2012.04.009 [eCite] [Details]

Citations: Scopus - 12Web of Science - 12

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2012Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, et al., 'Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010', Lancet, 380, (9859) pp. 2163-2196. ISSN 0140-6736 (2012) [Refereed Article]

DOI: 10.1016/S0140-6736(12)61729-2 [eCite] [Details]

Citations: Scopus - 3574Web of Science - 3332

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2011Laslett LL, Lynch J, Sullivan TR, McNeil JD, 'Osteoporosis education improves osteoporosis knowledge and dietary calcium: comparison of a 4 week and a one-session education course', International Journal of Rheumatic Diseases, 14, (3) pp. 239-247. ISSN 1756-1841 (2011) [Refereed Article]

DOI: 10.1111/j.1756-185X.2011.01628.x [eCite] [Details]

Citations: Scopus - 15Web of Science - 12

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2011Valdes AM, De Wilde G, Doherty SA, Lories RJ, Vaughn FL, et al., 'The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis', Annals of The Rheumatic Diseases: The Eular Journal, 70, (9) pp. 1556-1561. ISSN 0003-4967 (2011) [Refereed Article]

DOI: 10.1136/ard.2010.148122 [eCite] [Details]

Citations: Scopus - 81Web of Science - 70

Co-authors: Jones G

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2011Wei S, Venn A, Ding C, Foley S, Laslett L, et al., 'The association between oral contraceptive use, bone mineral density and fractures in women aged 50-80 years', Contraception, 84, (4) pp. 357-362. ISSN 0010-7824 (2011) [Refereed Article]

DOI: 10.1016/j.contraception.2011.02.001 [eCite] [Details]

Citations: Scopus - 9Web of Science - 8

Co-authors: Wei S; Venn A; Ding C; Foley S; Jones G

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2010Wei S, Winzenberg T, Laslett LL, Venn A, Jones G, 'Oral contraceptive use and bone', Current Osteoporosis Reports , 9, (1) pp. 6-11. ISSN 1544-2241 (2010) [Refereed Article]

DOI: 10.1007/s11914-010-0037-9 [eCite] [Details]

Citations: Scopus - 14

Co-authors: Wei S; Winzenberg T; Venn A; Jones G

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2009Redmond CL, Bain GI, Laslett LL, McNeil JD, 'Hand syndromes associated with diabetes: impairments and obesity predict disability', Journal of Rheumatology, 36, (12) pp. 2766-2771. ISSN 0315-162X (2009) [Refereed Article]

DOI: 10.3899/jrheum.090239 [eCite] [Details]

Citations: Scopus - 25Web of Science - 24

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2008Laslett LL, Burnet SP, Redmond CL, McNeil JD, 'Predictors of shoulder pain and shoulder disability after one year in diabetic outpatients', Rheumatology, 47, (10) pp. 1583-1586. ISSN 1462-0324 (2008) [Refereed Article]

DOI: 10.1093/rheumatology/ken333 [eCite] [Details]

Citations: Scopus - 21Web of Science - 17

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Chapter in Book

(1 outputs)
YearCitationAltmetrics
2014Laslett LL, Jones G, 'Capsaicin for Osteoarthritis Pain', Capsaicin as a Therapeutic Molecule, Springer, Abdel-Salam, Omar M.E (ed), Basel, pp. 277-291. ISBN 978-3-0348-0828-6 (2014) [Research Book Chapter]

DOI: 10.1007/978-3-0348-0828-6_11 [eCite] [Details]

Citations: Scopus - 33

Co-authors: Jones G

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Grants & Funding

Dr Laslett has received over $170,000 in competitive grant funding.These include grants for the Modic back pain trial from the Tasmanian Community Fund ($88,721.10, 2014) and Arthritis Australia ($30,000, 2013).

Funding Summary

Number of grants

9

Total funding

$1,436,210

Projects

Assessing the Australian osteoarthritis landscape - GPs' surgeons' and patients attitudes towards and understandings of osteoarthritis (2018)$24,824
Description
Osteoarthritis is a leading cause of pain and disability among older people and there is currently no cure. In recent years, there has been increasing concern about the discrepancies between care provided by health professionals and recommendations in osteoarthritis clinical practice guideline. For instance, in Australia, referral to a surgeon is five times more common than referral to allied health professionals that could help with conservative management. Furthermore, patients are ambivalent towards conservative management such as exercise, thinking it will be ineffective and may even cause harm to their already worn joints. The disconnect between practice guideline and care for patients with osteoarthritis limits optimal care. Therefore, this study aims to explore the attitudes towards and understanding of osteoarthritis held by Australian GPs, surgeons and patients with knee osteoarthritis. The overarching goal is to gather information needed to develop Australian-specific education and behaviour change programs for GPs, surgeons and osteoarthritis patients
Funding
University of Tasmania ($24,824)
Scheme
Grant- Research Enhancement Program
Administered By
University of Tasmania
Research Team
Balogun S; Aitken D; Winzenberg TM; Hansen EC; Newsham-West H; Laslett LL
Year
2018
Is the use of thermocyclopad effective for knee pain? (2016)$50,336
Description
Clinical trial to assess the efficacy daily use of the Niagara Thermo Cyclo Pad unit on the heat and vibrate settings, or the heat and vibrate settings plus use of the hand held unit will reduce knee pain, stiffness and symptoms over four weeks compared to the sham pad, for knee OA pain, function and stiffness.
Funding
CT Healthcare Pty Ltd ($50,336)
Scheme
Clinical Trial
Administered By
University of Tasmania
Research Team
Jones Graeme; Laslett LL
Year
2016
A randomised trial of krill oil for osteoarthritis of the knee (2016 - 2019)$851,491
Description
Knee osteoarthritis (OA) is a significant and increasing cause of pain and disability in the aging Australian population, but interventions aimed at structural modification have been disappointing. Pilot data shows that krill oil reduces knee pain and systemic inflammation after 30 days, suggesting that an approach targeted at specific mechanisms of disease is effective in reducing painful OA. However, this pilot study was short, did not collect any data on structural factors, and included patients with a variety of disorders.We aim to compare, using a randomised, placebo-controlled double-blind design over six months, the efficacy of krill oil vs placebo in the treatment of osteoarthritis (OA) of the knee in 260 patients with clinical knee OA, significant knee pain and effusions, both with regard to control of symptoms and localised inflammation.Key hypothesis: Krill oil decreases pain (assessed by 100mm VAS) by 10mm more than identical placebo over 24 weeks in patients with clinical knee OA, significant knee pain and effusions.Secondary hypotheses: Krill oil improves knee pain over 4, 8, 12, 16, and 20 weeks in patients with clinical knee OA.Krill oil decreases effusion size by 20% over 24 weeks in patients with symptomatic osteoarthritis of the knee and knee effusion.If krill oil can both improve symptoms and decrease effusion in OA it has the potential to slow progression to joint replacement. The proposed study represents an innovative approach to this and lends itself to easy implementation as krill oil is already available overthecounter in Australian pharmacies.
Funding
National Health & Medical Research Council ($751,491)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Jones Graeme; Wluka A; Hill Catherine; March L; Keen H; Laslett LL
Period
2016 - 2019
Grant Reference
1102732
The effect of krill oil on cartilage composition (2016)$30,000
Description
Aims: to compare efficacy of krill oil vs identical placebo on cartilage composition (T2 mapping values) in 260patients with clinical knee OA, significant knee pain and effusion on imaging, using a randomised, placebocontrolled doubleblind design over six months in an NHMRC-funded clinical trial.
Funding
Menzies Institute for Medical Research ($30,000)
Scheme
Grant - Development Grant
Administered By
University of Tasmania
Research Team
Laslett LL; Eathakkattu Antony BS; Aitken D
Year
2016
Clinical trials in osteoarthritis (2014 - 2017)$304,596
Funding
National Health & Medical Research Council ($304,596)
Scheme
Fellowship-Early Career
Administered By
University of Tasmania
Research Team
Laslett LL
Period
2014 - 2017
Grant Reference
1070586
Does either zoledronic acid or denosumab change back pain and morphology of Modic changes: a randomised open label pilot study (2014)$30,000
Description
This research aims to determine whether two different bone active medications (zoledronic acid 5mg; denosumab 60mg) will modify back pain and structural abnormalities over six months in people with severe back pain and certain changes on magnetic resonance imaging (MRI). This will allow us to decide whether these medications have a large enough effect to warrant further clinical study.
Funding
Arthritis Australia ($30,000)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Laslett LL; Jones Graeme
Year
2014
Testing new treatments for back pain: a randomised open label pilot study (2014)$88,721
Description
This project will conduct a randomised open label pilot study on two potential treatments for back pain targeting Modic changes (zoledronic acid or denosumab).
Funding
Tasmanian Community Fund ($88,721)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Laslett LL; Aitken D; Jones Graeme
Year
2014
Humira for treatment of erosive hand osteoarthritis (2013)$50,000
Funding
Arthritis Australia ($50,000)
Scheme
Fellowship-Research
Administered By
University of Tasmania
Research Team
Laslett LL
Year
2013
2012 OARSI Young Investigator Scholarship (2012)$6,242
Funding
Osteoarthritis Research Society International ($6,242)
Scheme
Scholarship-Exchange
Administered By
University of Tasmania
Research Team
Laslett LL
Year
2012

Research Supervision

Dr Laslett has co-supervised one PhD candidate and one Honours student to completion.  She currently co-supervise two PhD candidates (Feitong Wu and Zhaohua Zhu) and one Honours student (Sarah Mattap).

She is interested in supervising new PhD candidates or Honours students on aspects of osteoarthritis epidemiology, specifically factors relating to knee pains.

Current

6

Completed

2

Current

DegreeTitleCommenced
PhDHand and Knee Joints Pathological Abnormalities via Magnetic Resonance Imaging; Their Role in Pain, Physical Functional Deficits, and Cartilage Volume Loss in Older Adult Cohort2016
PhDEvaluate the Efficacy and Safety of Zoledronic Acid in Pain and Structural Changes in Knee Osteoarthritis and Back Pain2016
PhDAssociations of Physical Activity, Physical Performance Measures and Obesity in Childhood with Knee Cartilage Thickness in Adults after 25 Years2016
PhDCorrelates and Relevance of MicroCT Measurement in Older Adults2017
PhDThe Effect Of Medication Use on Osteoarthritis Over 10 Years2018
MastersObjective Patient Centred Outcomes: Movement data in orthopaedic surgery2019

Completed

DegreeTitleCompleted
PhDSubchondral Bone Abnormalities in Knee Osteoarthritis
Candidate: Zhaohua Zhu
2017
PhDStrategies to Address the Long-Term Maintenance of Bone Mineral Density in Younger Women
Candidate: Feitong Wu
2016