Profiles

Steve Simpson JR

UTAS Home Dr Steve Simpson, Jr

Steve Simpson, Jr

MSRA Postdoctoral Research Fellow
Menzies Institute for Medical Research

Room 357-02, Medical Science 2, Hobart CBD Campuses

+61 3 6226 4718 (phone)

+61 3 6226 7704 (fax)

Steve.Simpson@utas.edu.au

Steve Simpson, Jr's research is predominantly in the field of multiple sclerosis epidemiology, particularly its geoepidemiology and the distribution and determinants of its clinical course. He also works in HR-HPV-associated neoplasia and sexual health. The highlights of Steve's work heretofore has been:

  • Meta-analysis of global MS prevalence and the latitudinal gradient thereof
  • The developing role of vitamin D and sun/UV in multiple sclerosis onset and clinical course
  • Evaluating the female preponderance of HR-HPV-mediated anal neoplasia

Biography

Steve is an early-career researcher in the field of multiple sclerosis. Following undergraduate training in biology at Hunter College in New York City and postgraduate studies in public health and infectious disease at the University of California, Berkeley, both of which he completed with high distinction, Steve undertook doctoral research in multiple sclerosis geoepidemiology and predictors of clinical course at the Menzies Institute for Medical Research, University of Tasmania between 2008-2011, completing his PhD with high distinction in 2011. After a year of postdoctoral research on the same topic, also at Menzies, he was awarded an MSRA postdoctoral research fellowship in 2012, under which he continue to work at the present.

Career summary

Qualifications

  • PhD, University of Tasmania, Australia, 2011. On the geoepidemiology of multiple sclerosis and environmental & infectious determinants of its clinical course
  • MPH (Infectious Disease), University of California, Berkley, USA, 2007
  • BA (Biological Sciences & Biochemistry), Hunter College (CUNY), USA, 2005

Memberships

Professional practice

  • Australasian Epidemiological Association
  • International Epidemiological Association
  • Public Health Association of Australia
  • International Anal Neoplasia Society

Administrative expertise

  • Manage/managed TasGANS, CIPRIS and RUSSL studies, including administration, acquiring funds and managing personnel therein
  • Primary data administrator for AusLong Study

Teaching

Epidemiology, Biostatistics

Teaching responsibility

View more on Dr Steve Simpson JR in WARP

Expertise

  • Multiple sclerosis
  • Epidemiology
  • Geoepidemiology
  • Vitamin D
  • Human herpesvirus 6
  • Anal neoplasia
  • Human papillomavirus
  • Sexual health

Research Themes

Steve's research aligns to the University's research theme of Better Health. He is interested in the environmental and behavioural determinants and modulators of disease, particularly multiple sclerosis and sexually transmitted disease.

Collaboration

  • HR-HPV-associated neoplasia and sexual health, with Professor Richard Turner (UTAS SOM) and others
  • Evaluating the distribution and determinants of MS clinical course in early disease, Ausimmune/AusLong collaboration
  • Studies of multiple sclerosis epidemiology in various populations, with Dr Mike Boggild (QLD DHHS) and others

Awards

  • MS Research Australia Postdoctoral Research Fellowship, 2012-15
  • Annual Postgraduate Student Prize, 2012
  • Annual Postgraduate Student Prize, Menzies Research Institute Tasmania, 2011
  • Young Investigator Award, Multiple Sclerosis Research Australia, 2011
  • Finalist, Australian Society for Medical Research Student Award, 2010
  • University Fellowship, University of California, Berkeley, 2006-7
  • Magna Cum Laude University Honors, Hunter College, 2005
  • Biological Sciences Department Honors, Hunter College, 2005
  • McNair Post-Baccalaureate Scholar, Hunter College, 2004

Current projects

Fields of Research

  • Central Nervous System (110903)
  • Epidemiology (111706)
  • Neurology and Neuromuscular Diseases (110904)
  • Preventive Medicine (111716)
  • Pathology (110316)
  • Cancer Diagnosis (111202)
  • Health Economics (140208)
  • Public Health and Health Services (111799)
  • Health and Community Services (111708)
  • Cell Metabolism (060104)
  • Infectious Diseases (110309)
  • Primary Health Care (111717)
  • Family Care (111707)
  • Genomics (060408)
  • Anaesthesiology (110301)
  • Respiratory Diseases (110203)
  • Mental Health (111714)
  • Surgery (110323)
  • Autonomic Nervous System (110901)
  • Autoimmunity (110703)
  • Nutrition and Dietetics (111199)
  • Endocrinology (110306)
  • Separation Science (030108)
  • Immunology (110799)
  • Immunogenetics (incl. Genetic Immunology) (110706)
  • Health Information Systems (incl. Surveillance) (111711)
  • Cellular Immunology (110704)
  • Health Promotion (111712)
  • Pharmacology and Pharmaceutical Sciences (111599)

Research Objectives

  • Nervous System and Disorders (920111)
  • Disease Distribution and Transmission (incl. Surveillance and Response) (920404)
  • Preventive Medicine (920412)
  • Cancer and Related Disorders (920102)
  • Public Health (excl. Specific Population Health) (920499)
  • Infectious Diseases (920109)
  • Diabetes (920104)
  • Evaluation of Health Outcomes (920204)
  • Women's Health (920507)
  • Behaviour and Health (920401)
  • Disability and Functional Capacity (920403)
  • Immune System and Allergy (920108)
  • Neurodegenerative Disorders Related to Ageing (920112)
  • Blood Disorders (920101)
  • Surgical Methods and Procedures (920118)
  • Clinical Health (Organs, Diseases and Abnormal Conditions) (920199)
  • Expanding Knowledge in the Medical and Health Sciences (970111)
  • Expanding Knowledge in the Chemical Sciences (970103)
  • Expanding Knowledge in the Biological Sciences (970106)
  • Carer Health (920202)
  • Diagnostic Methods (920203)
  • Specific Population Health (excl. Indigenous Health) (920599)
  • Health Protection and/or Disaster Response (920407)
  • Health Inequalities (920206)
  • Health Status (e.g. Indicators of Well-Being) (920408)
  • Health Education and Promotion (920205)
  • Education and Training (939999)
  • Social Structure and Health (920413)
  • Health and Support Services (920299)

Publications

Despite the early stage of Steve's career, he has already made significant contributions to his research field. His H Index is 8, including 16 first or senior-author publications and eight second-author publications, as well as other publications, which together have been cited 985 times (729 for epidemiology & vitamin D-related papers). Steve has presented his work at 14 domestic and international conferences.

Steve is Editor of the journal of the Australasian Epidemiologic Association, Australasian Epidemiologist.

Total publications

80

Highlighted publications

(3 outputs)
YearTypeCitationAltmetrics
2012Journal ArticleStewart N, Simpson Jr S, van der Mei I, Ponsonby A-L, Blizzard L, et al., 'Interferon-β and serum 25-hydroxyvitamin D interact to modulate relapse risk in MS', Neurology, 79, (3) pp. 254-260. ISSN 0028-3878 (2012) [Refereed Article]

DOI: 10.1212/WNL.0b013e31825fded9 [eCite] [Details]

Citations: Scopus - 61Web of Science - 55

Co-authors: Stewart N; van der Mei I; Blizzard L; Pittas F; Taylor BV

Tweet

2011Journal ArticleSimpson Jr S, Blizzard L, Otahal P, Van der Mei I, Taylor B, 'Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis', Journal of Neurology, Neurosurgery and Psychiatry, 82, (10) pp. 1132-1141. ISSN 0022-3050 (2011) [Refereed Article]

DOI: 10.1136/jnnp.2011.240432 [eCite] [Details]

Citations: Scopus - 342Web of Science - 305

Co-authors: Blizzard L; Otahal P; Van der Mei I; Taylor B

Tweet

2010Journal ArticleSimpson S, Taylor B, Blizzard L, Ponsonby AL, Pittas F, et al., 'Higher 25-hydroxyvitamin D is associated with lower relapse risk in Multiple Sclerosis', Annals of Neurology, 68, (2) pp. 193-203. ISSN 0364-5134 (2010) [Refereed Article]

DOI: 10.1002/ana.22043 [eCite] [Details]

Citations: Scopus - 323Web of Science - 295

Co-authors: Taylor B; Blizzard L; Pittas F; van der Mei I

Tweet

Journal Article

(76 outputs)
YearCitationAltmetrics
2019Campbell JA, Simpson Jr S, Ahmad H, Taylor BV, van der Mei I, et al., 'Change in multiple sclerosis prevalence over time in Australia 2010-2017 utilising disease modifying therapy prescription data', Multiple Sclerosis Journal pp. 1-14. ISSN 1352-4585 (2019) [Refereed Article]

DOI: 10.1177/1352458519861270 [eCite] [Details]

Co-authors: Campbell JA; Ahmad H; Taylor BV; van der Mei I; Palmer AJ

Tweet

2019Gascoyne CR, Simpson Jr S, Chen J, van der Mei I, Marck CH, 'Modifiable factors associated with depression and anxiety in multiple sclerosis', Acta Neurologica Scandinavica pp. 1-8. ISSN 0001-6314 (2019) [Refereed Article]

DOI: 10.1111/ane.13132 [eCite] [Details]

Co-authors: van der Mei I

Tweet

2019Lin C, Slama J, Gonzalez P, Goodman MT, Xia N, et al., 'Cervical determinants of anal HPV infection and high-grade anal lesions in women: a collaborative pooled analysis', Lancet Infectious Diseases pp. 1-12. ISSN 1473-3099 (2019) [Refereed Article]

DOI: 10.1016/S1473-3099(19)30164-1 [eCite] [Details]

Citations: Scopus - 1

Tweet

2019Marck CH, Aitken Z, Simpson Jr S, Weiland TJ, Kavanagh A, et al., 'Predictors of change in employment status and associations with quality of life: a prospective international study of people with multiple sclerosis', Journal of Occupational Rehabilitation pp. 1-10. ISSN 1053-0487 (2019) [Refereed Article]

DOI: 10.1007/s10926-019-09850-5 [eCite] [Details]

Tweet

2019Palmer AJ, van der Mei I, Taylor BV, Clarke PM, Simpson Jr S, et al., 'Modelling the impact of multiple sclerosis on life expectancy, quality-adjusted life years and total lifetime costs: Evidence from Australia', Multiple Sclerosis Journal pp. 1-10. ISSN 1352-4585 (2019) [Refereed Article]

DOI: 10.1177/1352458519831213 [eCite] [Details]

Citations: Scopus - 2

Co-authors: Palmer AJ; van der Mei I; Taylor BV; Ahmad H

Tweet

2019Phyo AZZ, Jelinek GA, Brown CR, O'Kearney E, Neate SL, et al., 'Differential multiple sclerosis treatment allocation between Australia and New Zealand associated with clinical outcomes but not mood or quality of life', Multiple Sclerosis and Related Disorders, 30 pp. 25-32. ISSN 2211-0348 (2019) [Refereed Article]

DOI: 10.1016/j.msard.2019.01.037 [eCite] [Details]

Tweet

2019Simpson Jr S, Taylor KL, Jelinek GA, De Livera AM, Brown CR, et al., 'Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS', Multiple Sclerosis and Related Disorders, 30 pp. 165-175. ISSN 2211-0348 (2019) [Refereed Article]

DOI: 10.1016/j.msard.2019.02.014 [eCite] [Details]

Tweet

2019Simpson Jr S, Wang W, Otahal P, Blizzard L, van der Mei IAF, et al., 'Latitude continues to be significantly associated with the prevalence of multiple sclerosis: an updated meta-analysis', Journal of Neurology, Neurosurgery and Psychiatry, (June) pp. 1-8. ISSN 0022-3050 (2019) [Refereed Article]

DOI: 10.1136/jnnp-2018-320189 [eCite] [Details]

Co-authors: Otahal P; Blizzard L; van der Mei IAF; Taylor BV

Tweet

2019Szoeke C, Goodwill AM, Gorelik A, Dennerstein L, Caeyenberghs K, et al., 'Apolipoprotein E4 mediates the association between midlife dyslipidemia and cerebral amyloid in aging women', Journal of Alzheimer's Disease, 68, (1) pp. 105-114. ISSN 1387-2877 (2019) [Refereed Article]

DOI: 10.3233/JAD-180815 [eCite] [Details]

Co-authors: Hill E

Tweet

2019Turner RC, Simpson Jr S, Bhalerao M, 'Systemic predictors of adverse events in a national surgical mortality audit: analysis of peer-review data from Australia and New Zealand Audit of Surgical Mortality', ANZ Journal of Surgery pp. 1-6. ISSN 1445-1433 (2019) [Refereed Article]

DOI: 10.1111/ans.15386 [eCite] [Details]

Co-authors: Turner RC; Bhalerao M

Tweet

2019Zhang Y, Zhou Y, van der Mei IAF, Simpson Jr S, Ponsonby A-L, et al., 'Lipid-related genetic polymorphisms significantly modulate the association between lipids and disability progression in multiple sclerosis', Journal of Neurology, Neurosurgery and Psychiatry pp. 1-6. ISSN 0022-3050 (2019) [Refereed Article]

DOI: 10.1136/jnnp-2018-319870 [eCite] [Details]

Citations: Scopus - 1

Co-authors: Zhang Y; Zhou Y; van der Mei IAF; Tettey P; Charlesworth J; Taylor BV

Tweet

2019Hu Q, Chen H, Zuo Y, He Q, He X, et al., 'Role of PCK1 gene on oil tea-induced glucose homeostasis and type 2 diabetes: An animal experiment and a case-control study', Nutrition & Metabolism, 16, (1) Article 12. ISSN 1743-7075 (2019) [Refereed Article]

DOI: 10.1186/s12986-019-0337-8 [eCite] [Details]

Tweet

2018Weiland TJ, De Livera AM, Brown CR, Jelinek GA, Aitken Z, et al., 'Health outcomes and lifestyle in a sample of people with multiple sclerosis (HOLISM): longitudinal and validation cohorts', Frontiers in Neurology, 9 Article 1074. ISSN 1664-2295 (2018) [Refereed Article]

DOI: 10.3389/fneur.2018.01074 [eCite] [Details]

Citations: Web of Science - 1

Tweet

2018Chen J, Taylor B, Palmer AJ, Kirk-Brown A, van Dijk P, et al., 'Estimating MS-related work productivity loss and factors associated with work productivity loss in a representative Australian sample of people with multiple sclerosis', Multiple Sclerosis Journal, (June) pp. 1-11. ISSN 1352-4585 (2018) [Refereed Article]

DOI: 10.1177/1352458518781971 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Taylor B; Palmer AJ; Blizzard L; van der Mei I

Tweet

2018Graves JS, Barcellos LF, Simpson S, Belman A, Lin R, et al., 'The multiple sclerosis risk allele within the AHI1 gene is associated with relapses in children and adults', Multiple Sclerosis and Related Disorders, 19 pp. 161-165. ISSN 2211-0348 (2018) [Refereed Article]

DOI: 10.1016/j.msard.2017.10.008 [eCite] [Details]

Citations: Scopus - 3Web of Science - 4

Co-authors: Taylor BV; Ponsonby A-L; Dwyer T; van der Mei IAF

Tweet

2018Jelinek PL, Simpson Jr S, Brown CR, Jelinek GA, Marck CH, et al., 'Self-reported cognitive function in a large international cohort of people with multiple sclerosis: associations with lifestyle and other factors', European Journal of Neurology, 26, (1) pp. 142-154. ISSN 1351-5101 (2018) [Refereed Article]

DOI: 10.1111/ene.13784 [eCite] [Details]

Citations: Scopus - 2Web of Science - 1

Tweet

2018Leong TI, Weiland TJ, Jelinek GA, Simpson S, Brown CR, et al., 'Longitudinal associations of the healthy lifestyle index score with quality of life in people with multiple sclerosis: A prospective cohort study', Frontiers in Neurology, 9 Article 874. ISSN 1664-2295 (2018) [Refereed Article]

DOI: 10.3389/fneur.2018.00874 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Tweet

2018Ahmad H, van der Mei I, Taylor BV, Lucas RM, Ponsonby A-L, et al., 'Estimation of annual probabilities of changing disability levels in Australians with relapsing-remitting multiple sclerosis', Multiple Sclerosis Journal pp. 1-9. ISSN 1352-4585 (2018) [Refereed Article]

DOI: 10.1177/1352458518806103 [eCite] [Details]

Citations: Scopus - 1

Co-authors: Ahmad H; van der Mei I; Taylor BV; Palmer AJ

Tweet

2018Saul A, Taylor B, Simpson Jr S, Ponsonby A-L, Blizzard L, et al., 'Polymorphism in the serotonin transporter gene polymorphisms (5-HTTLPR) modifies the association between significant life events and depression in people with multiple sclerosis', Multiple Sclerosis Journal pp. 1-8. ISSN 1352-4585 (2018) [Refereed Article]

DOI: 10.1177/1352458518770021 [eCite] [Details]

Co-authors: Saul A; Taylor B; Blizzard L; Wood B; van der Mei IAF

Tweet

2018Simpson Jr S, Van Der Mei I, Lucas RM, Ponsonby A-L, Broadley S, et al., 'Sun exposure across the life course significantly modulates early multiple sclerosis clinical course', Frontiers in Neurology, 9, (FEB) Article 16. ISSN 1664-2295 (2018) [Refereed Article]

DOI: 10.3389/fneur.2018.00016 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Van Der Mei I; Blizzard L; Taylor B

Tweet

2018Simpson Jr S, van der Mei I, Taylor B, 'The role of vitamin D in multiple sclerosis: biology & biochemistry, epidemiology and potential roles in treatment', Medicinal Chemistry, 14, (2) pp. 129-143. ISSN 1573-4064 (2018) [Refereed Article]

DOI: 10.2174/1573406413666170921143600 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: van der Mei I; Taylor B

Tweet

2018Tao C, Simpson Jr S, Taylor BV, Blizzard L, Lucas RM, et al., 'Onset symptoms, tobacco smoking, and progressive-onset phenotype are associated with a delayed onset of multiple sclerosis, and marijuana use with an earlier onset', Frontiers in Neurology, 9, (JUN) Article 418. ISSN 1664-2295 (2018) [Refereed Article]

DOI: 10.3389/fneur.2018.00418 [eCite] [Details]

Citations: Scopus - 1

Co-authors: Taylor BV; Blizzard L; van der Mei I

Tweet

2018Taylor KL, Simpson Jr S, Jelinek GA, Neate SL, De Livera AM, et al., 'Longitudinal associations of modifiable lifestyle factors with positive depression-screen over 2.5-years in an international cohort of people living with multiple sclerosis', Frontiers in Psychiatry, 9 Article 526. ISSN 1664-0640 (2018) [Refereed Article]

DOI: 10.3389/fpsyt.2018.00526 [eCite] [Details]

Citations: Web of Science - 2

Tweet

2018Chen J, Taylor BV, Blizzard L, Simpson Jr S, Palmer AJ, et al., 'Effects of multiple sclerosis disease-modifying therapies on employment measures using patient-reported data', Journal of Neurology, Neurosurgery and Psychiatry, 89, (11) pp. 1200-1207. ISSN 0022-3050 (2018) [Refereed Article]

DOI: 10.1136/jnnp-2018-318228 [eCite] [Details]

Citations: Scopus - 3Web of Science - 2

Co-authors: Taylor BV; Blizzard L; Palmer AJ; van der Mei IAF

Tweet

2018Zhang Y, Taylor BV, Simpson Jr S, Blizzard L, van der Mei I, 'Patient-reported outcomes are worse for progressive-onset multiple sclerosis than relapse-onset multiple sclerosis, particularly early in the disease process', European Journal of Neurology, 26, (1) pp. 155-161. ISSN 1351-5101 (2018) [Refereed Article]

DOI: 10.1111/ene.13786 [eCite] [Details]

Citations: Scopus - 2

Co-authors: Zhang Y; Taylor BV; Blizzard L; van der Mei I

Tweet

2018Zhou Y, Chen M, Simpson Jr S, Lucas RM, Charlesworth JC, et al., 'Common genetic variation within miR-146a predicts disease onset and relapse in multiple sclerosis', Neurological Sciences, 39, (2) pp. 297-304. ISSN 1590-1874 (2018) [Refereed Article]

DOI: 10.1007/s10072-017-3177-1 [eCite] [Details]

Citations: Scopus - 4Web of Science - 1

Co-authors: Zhou Y; Charlesworth JC; Blackburn N; van der Mei I; Taylor BV

Tweet

2018Lin R, He X, Chen H, He Q, Yao Z, et al., 'Oil tea improves glucose and lipid levels and alters gut microbiota in type 2 diabetic mice', Nutrition Research, 57 pp. 67-77. ISSN 0271-5317 (2018) [Refereed Article]

DOI: 10.1016/j.nutres.2018.05.004 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Tweet

2017Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, et al., 'Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data', BMJ, 356 Article i6583. ISSN 1756-1833 (2017) [Refereed Article]

DOI: 10.1136/bmj.i6583 [eCite] [Details]

Citations: Scopus - 185Web of Science - 158

Tweet

2017Odenthal C, Simpson Jr S, Oughton J, van der Mei I, Rose S, et al., 'Midsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: A multicentre Australian cohort study', Journal of Medical Imaging and Radiation Oncology, 61, (4) pp. 453-460. ISSN 1754-9477 (2017) [Refereed Article]

DOI: 10.1111/1754-9485.12570 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: van der Mei I; Taylor B

Tweet

2017Saul A, Ponsonby A-L, Lucas RM, Taylor BV, Simpson Jr S, et al., 'Stressful life events and the risk of initial central nervous system demyelination', Multiple Sclerosis Journal, 23, (7) pp. 1000-1007. ISSN 1352-4585 (2017) [Refereed Article]

DOI: 10.1177/1352458516667566 [eCite] [Details]

Citations: Scopus - 1Web of Science - 2

Co-authors: Saul A; Taylor BV; van der Mei IAF

Tweet

2017Simpson S, Clifford C, Quinn MG, Ross K, Sefton NS, et al., 'Sexuality-related attitudes significantly modulate demographic variation in sexual health literacy in Tasmanian university students', Sexual Health, 14, (3) pp. 244-253. ISSN 1448-5028 (2017) [Refereed Article]

DOI: 10.1071/SH16135 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Clifford C; Quinn MG; Ross K; Sefton NS; Blizzard L; Turner R

Tweet

2017Tao C, Simpson Jr S, Taylor BV, van der Mei I, 'Association between human herpesvirus & human endogenous retrovirus and MS onset & progression', Journal of the Neurological Sciences, 372 pp. 239-249. ISSN 0022-510X (2017) [Refereed Article]

DOI: 10.1016/j.jns.2016.11.060 [eCite] [Details]

Citations: Scopus - 7Web of Science - 8

Co-authors: Taylor BV; van der Mei I

Tweet

2017Tettey P, Simpson S, Taylor B, Ponsonby A-L, Lucas RM, et al., 'An adverse lipid profile and increased levels of adiposity significantly predict clinical course after a first demyelinating event', Journal of Neurology, Neurosurgery and Psychiatry, 88, (5) pp. 395-401. ISSN 0022-3050 (2017) [Refereed Article]

DOI: 10.1136/jnnp-2016-315037 [eCite] [Details]

Citations: Scopus - 26Web of Science - 25

Co-authors: Tettey P; Taylor B; van der Mei IAF

Tweet

2017Zhou Y, Graves JS, Simpson S, Charlesworth JC, van der Mei I, et al., 'Genetic variation in the gene LRP2 increases relapse risk in multiple sclerosis', Journal of Neurology, Neurosurgery and Psychiatry, 88, (10) pp. 864-868. ISSN 0022-3050 (2017) [Refereed Article]

DOI: 10.1136/jnnp-2017-315971 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Zhou Y; Charlesworth JC; van der Mei I; Taylor BV

Tweet

2017Zhou Y, Simpson Jr S, Charlesworth JC, van der Mei I, Lucas RM, et al., 'Variation within MBP gene predicts disease course in multiple sclerosis', Brain and Behavior, 7, (4) Article e00670. ISSN 2162-3279 (2017) [Refereed Article]

DOI: 10.1002/brb3.670 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

Co-authors: Charlesworth JC; van der Mei I; Taylor BV

Tweet

2016Pan G, Simpson Jr S, van der Mei I, Charlesworth JC, Lucas R, et al., 'Role of genetic susceptibility variants in predicting clinical course in multiple sclerosis: a cohort study', Journal of Neurology, Neurosurgery and Psychiatry, 87, (11) pp. 1204-1211. ISSN 0022-3050 (2016) [Refereed Article]

DOI: 10.1136/jnnp-2016-313722 [eCite] [Details]

Citations: Scopus - 19Web of Science - 15

Co-authors: van der Mei I; Charlesworth JC; Zhou Y; Wu F; Taylor BV

Tweet

2016Simpson JR S, Stewart N, van der Mei I, Blizzard L, Taylor BV, 'Synergetic and antagonistic effects of combined calcitriol and interferon-β treatment on cytokine production by stimulated PBMCs', Journal of Neuroimmunology, 297 pp. 148-155. ISSN 0165-5728 (2016) [Refereed Article]

DOI: 10.1016/j.jneuroim.2016.05.020 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

Co-authors: Stewart N; van der Mei I; Blizzard L; Taylor BV

Tweet

2016Simpson Jr S, Blomfield P, Cornall A, Tabrizi SN, Blizzard L, et al., 'Front-to-back and dabbing wiping behaviour post-toilet associated with anal neoplasia and HR-HPV carriage in women with previous HPV-mediated gynaecological neoplasia', Cancer Epidemiology, 42 pp. 124-132. ISSN 1877-7821 (2016) [Refereed Article]

DOI: 10.1016/j.canep.2016.04.001 [eCite] [Details]

Citations: Scopus - 12Web of Science - 10

Co-authors: Blomfield P; Blizzard L; Turner R

Tweet

2016Simpson S, Tan H, Otahal P, Taylor B, Ponsonby AL, et al., 'Anxiety, depression and fatigue at 5-year review following CNS demyelination', Acta Neurologica Scandinavica, 134, (6) pp. 403-413. ISSN 0001-6314 (2016) [Refereed Article]

DOI: 10.1111/ane.12554 [eCite] [Details]

Citations: Scopus - 25Web of Science - 21

Co-authors: Tan H; Otahal P; Taylor B; Blizzard L; van der Mei I

Tweet

2016Tang Z, Fang Z, Huang W, Liu Z, Chen Y, et al., 'Non-Obese Diabetes and Its Associated Factors in an Underdeveloped Area of South China, Guangxi', International Journal of Environmental Research and Public Health, 13, (10) Article 976. ISSN 1660-4601 (2016) [Refereed Article]

DOI: 10.3390/ijerph13100976 [eCite] [Details]

Citations: Scopus - 2Web of Science - 1

Co-authors: Taylor BV

Tweet

2016Tao C, Simpson Jr S, van der Mei I, Blizzard L, Havrdova E, et al., 'Higher latitude is significantly associated with an earlier age of disease onset in multiple sclerosis', Journal of Neurology, Neurosurgery and Psychiatry, 87, (12) pp. 1343-1349. ISSN 0022-3050 (2016) [Refereed Article]

DOI: 10.1136/jnnp-2016-314013 [eCite] [Details]

Citations: Scopus - 21Web of Science - 19

Co-authors: van der Mei I; Blizzard L; Taylor BV

Tweet

2016Tettey P, Siejka D, Simpson Jr S, Taylor B, Blizzard L, et al., 'Frequency of comorbidities and their association with clinical disability and relapse in Multiple Sclerosis', Neuroepidemiology, 46, (2) pp. 106-113. ISSN 0251-5350 (2016) [Refereed Article]

DOI: 10.1159/000442203 [eCite] [Details]

Citations: Scopus - 15Web of Science - 15

Co-authors: Tettey P; Siejka D; Taylor B; Blizzard L; van der Mei I

Tweet

2016Zhou Y, Zhu G, Charlesworth JC, Simpson Jr S, Rubicz R, et al., 'Genetic loci for Epstein-Barr virus nuclear antigen-1 are associated with risk of multiple sclerosis', Multiple Sclerosis Journal, 22, (13) pp. 1655-1664. ISSN 1352-4585 (2016) [Refereed Article]

DOI: 10.1177/1352458515626598 [eCite] [Details]

Citations: Scopus - 15Web of Science - 10

Co-authors: Zhou Y; Charlesworth JC; Wu F; van der Mei I; Taylor BV

Tweet

2015Lin R, Taylor BV, Charlesworth J, van der Mei I, Blizzard L, et al., 'Modulating effects of WT1 on interferon-β-vitamin D association in MS', Acta Neurologica Scandinavica, 131, (4) pp. 231-239. ISSN 0001-6314 (2015) [Refereed Article]

DOI: 10.1111/ane.12315 [eCite] [Details]

Citations: Scopus - 10Web of Science - 10

Co-authors: Taylor BV; Charlesworth J; van der Mei I; Blizzard L; Stewart N; Pittas F

Tweet

2015Simpson JR S, Taylor BV, van der Mei I, 'The role of epidemiology in MS research: Past successes, current challenges and future potential', Multiple Sclerosis Journal, 21, (8) pp. 969-977. ISSN 1352-4585 (2015) [Refereed Article]

DOI: 10.1177/1352458515574896 [eCite] [Details]

Citations: Scopus - 21Web of Science - 16

Co-authors: Taylor BV; van der Mei I

Tweet

2015Simpson Jr S, Clifford C, Ross K, Sefton N, Owen L, et al., 'Sexual health literacy of the student population of the University of Tasmania: results of the RUSSL Study', Sexual Health (Print): an interdisciplinary journal of sexual health including HIV/AIDS and sexually transmitted infections, 12, (3) pp. 207-216. ISSN 1448-5028 (2015) [Refereed Article]

DOI: 10.1071/SH14223 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Clifford C; Ross K; Sefton N; Blizzard L; Turner R

Tweet

2015Simpson Jr S, Mina S, Morris H, Mahendran S, Taylor B, et al., 'The epidemiology of multiple sclerosis in the Isle of Man: 2006-2011', Acta Neurologica Scandinavica, 132, (6) pp. 381-388. ISSN 0001-6314 (2015) [Refereed Article]

DOI: 10.1111/ane.12405 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Taylor B

Tweet

2015Simpson Jr S, Stewart N, van der Mei I, Otahal P, Charlesworth J, et al., 'Stimulated PBMC-produced IFN-γ and TNF-α are associated with altered relapse risk in multiple sclerosis: Results from a prospective cohort study', Journal of Neurology, Neurosurgery and Psychiatry, 86 pp. 200-207. ISSN 0022-3050 (2015) [Refereed Article]

DOI: 10.1136/jnnp-2013-307336 [eCite] [Details]

Citations: Scopus - 19Web of Science - 11

Co-authors: Stewart N; van der Mei I; Otahal P; Charlesworth J; Blizzard L; Pittas F; Taylor B

Tweet

2015Simpson Jr S, van der Mei I, Stewart N, Blizzard L, Tettey P, et al., 'Weekly cholecalciferol supplementation results in significant reductions in infection risk among the vitamin D deficient: results from the CIPRIS pilot RCT', BMC Nutrition, 1 Article 7. ISSN 2055-0928 (2015) [Refereed Article]

DOI: 10.1186/2055-0928-1-7 [eCite] [Details]

Co-authors: van der Mei I; Stewart N; Blizzard L; Tettey P; Taylor B

Tweet

2015Tettey P, Simpson Jr S, Taylor BV, van der Mei IAF, 'The co-occurrence of multiple sclerosis and type 1 diabetes: Shared aetiologic features and clinical implication for MS aetiology', Journal of the Neurological Sciences, 348, (1-2) pp. 126-131. ISSN 0022-510X (2015) [Refereed Article]

DOI: 10.1016/j.jns.2014.11.019 [eCite] [Details]

Citations: Scopus - 15Web of Science - 17

Co-authors: Tettey P; Taylor BV; van der Mei IAF

Tweet

2015Zhou Y, Taylor B, van der Mei I, Stewart N, Charlesworth J, et al., 'Genetic variation in PBMC-produced IFN-γ and TNF-α associations with relapse in multiple sclerosis', Journal of The Neurological Sciences, 349, (1-2) pp. 40-44. ISSN 0022-510X (2015) [Refereed Article]

DOI: 10.1016/j.jns.2014.12.022 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Zhou Y; Taylor B; van der Mei I; Stewart N; Charlesworth J; Blizzard L; Pittas F

Tweet

2015Martin WG, Galligan J, Simpson JR Steve, Greenaway T, Burgess J, 'Admission blood glucose predicts mortality and length of stay in patients admitted through the emergency department', Internal Medicine Journal, 45, (9) pp. 916-24. ISSN 1444-0903 (2015) [Refereed Article]

DOI: 10.1111/imj.12841 [eCite] [Details]

Citations: Scopus - 11Web of Science - 10

Co-authors: Burgess J

Tweet

2014Knippenberg S, Damoiseaux J, Bol Y, Hupperts R, Taylor BV, et al., 'Higher levels of reported sun exposure, and not vitamin D status, are associated with less depressive symptoms and fatigue in multiple sclerosis', Acta Neurologica Scandinavica, 129, (2) pp. 123-131. ISSN 0001-6314 (2014) [Refereed Article]

DOI: 10.1111/ane.12155 [eCite] [Details]

Citations: Scopus - 23Web of Science - 23

Co-authors: Taylor BV; van der Mei IAF

Tweet

2014Lin R, Taylor BV, Simpson Jr S, Charlesworth J, Ponsonby A-L, et al., 'Association between multiple sclerosis risk-associated SNPs and relapse and disability - a prospective cohort study', Multiple Sclerosis, 20, (3) pp. 313-321. ISSN 1352-4585 (2014) [Refereed Article]

DOI: 10.1177/1352458513496882 [eCite] [Details]

Citations: Scopus - 18Web of Science - 16

Co-authors: Taylor BV; Charlesworth J; Pittas F; van der Mei I

Tweet

2014Lin R, Taylor BV, Simpson Jr S, Charlesworth J, Ponsonby A-L, et al., 'Novel modulating effects of PKC family genes on the relationship between serum vitamin D and relapse in multiple sclerosis', Journal of Neurology, Neurosurgery and Psychiatry, 85, (4) pp. 399-404. ISSN 0022-3050 (2014) [Refereed Article]

DOI: 10.1136/jnnp-2013-305245 [eCite] [Details]

Citations: Scopus - 20Web of Science - 20

Co-authors: Taylor BV; Charlesworth J; Pittas F; van der Mei IAF

Tweet

2014Simpson JR S, Taylor BV, 'The Scandinavian paradox revisited: Editorial comment on Berg-Hansen et al. 'High prevalence and no latitude gradient of multiple sclerosis in Norway'', Multiple Sclerosis Journal, 20, (13) pp. 1675-1677. ISSN 1352-4585 (2014) [Contribution to Refereed Journal]

DOI: 10.1177/1352458514535474 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Taylor BV

Tweet

2014Simpson Jr S, Taylor B, Burrows J, Burrows S, Dwyer DE, et al., 'EBV & HHV6 reactivation is infrequent and not associated with MS clinical course', Acta Neurologica Scandinavica, 130, (5) pp. 328-337. ISSN 0001-6314 (2014) [Refereed Article]

DOI: 10.1111/ane.12268 [eCite] [Details]

Citations: Scopus - 17Web of Science - 11

Co-authors: Taylor B; Blizzard L; Pittas F; van der Mei I

Tweet

2014Tettey P, Simpson Jr S, Taylor B, Blizzard L, Ponsonby A-L, et al., 'An adverse lipid profile is associated with disability and progression in disability, in people with MS', Multiple Sclerosis Journal, 20, (13) pp. 1737-1744. ISSN 1477-0970 (2014) [Refereed Article]

DOI: 10.1177/1352458514533162 [eCite] [Details]

Citations: Scopus - 51Web of Science - 43

Co-authors: Tettey P; Taylor B; Blizzard L; van der Mei I

Tweet

2014Tettey P, Simpson Jr S, Taylor B, Blizzard L, Ponsonby A-L, et al., 'Adverse lipid profile is not associated with relapse risk in MS: Results from an observational cohort study', Journal of the Neurological Sciences, 340, (1-2) pp. 230-232. ISSN 1878-5883 (2014) [Refereed Article]

DOI: 10.1016/j.jns.2014.02.038 [eCite] [Details]

Citations: Scopus - 20Web of Science - 19

Co-authors: Tettey P; Taylor B; Blizzard L; van der Mei I

Tweet

2014Tettey P, Simpson Jr S, Taylor BV, van der Mei IAF, 'Vascular comorbidities in the onset and progression of multiple sclerosis', Journal of The Neurological Sciences, 347, (1-2) pp. 23-33. ISSN 0022-510X (2014) [Refereed Article]

DOI: 10.1016/j.jns.2014.10.020 [eCite] [Details]

Citations: Scopus - 39Web of Science - 40

Co-authors: Tettey P; Taylor BV; van der Mei IAF

Tweet

2014Zhou Y, Simpson Jr S, Holloway AF, Charlesworth J, van der Mei I, et al., 'The potential role of epigenetic modifications in the heritability of multiple sclerosis', Multiple Sclerosis Journal, 20, (2) pp. 135-140. ISSN 1352-4585 (2014) [Refereed Article]

DOI: 10.1177/1352458514520911 [eCite] [Details]

Citations: Scopus - 19Web of Science - 20

Co-authors: Zhou Y; Holloway AF; Charlesworth J; van der Mei I; Taylor BV

Tweet

2014van der Mei IAF, Otahal P, Simpson Jr S, Taylor B, Winzenberg T, 'Meta-analyses to investigate gene-environment interactions in neuroepidemiology', Neuroepidemiology, 42, (1) pp. 39-49. ISSN 0251-5350 (2014) [Refereed Article]

DOI: 10.1159/000355439 [eCite] [Details]

Citations: Scopus - 3Web of Science - 2

Co-authors: van der Mei IAF; Otahal P; Taylor B; Winzenberg T

Tweet

2013Hunn BHM, Martin WG, Simpson Jr S, McLean CA, 'Idiopathic granulomatous hypophysitis: a systematic review of 82 cases in the literature', Pituitary pp. 1-9. ISSN 1573-7403 (2013) [Refereed Article]

DOI: 10.1007/s11102-013-0510-4 [eCite] [Details]

Citations: Scopus - 30Web of Science - 23

Co-authors: Hunn BHM

Tweet

2013Simpson Jr S, Blizzard L, Taylor B, Tettey P, van der Mei I, 'Is your association real or just reverse causality? Some examples from analyses of multiple sclerosis clinical course and tools to assess it', Australasian Epidemiologist, 20.1 pp. 34-37. ISSN 1327-8835 (2013) [Non Refereed Article]

[eCite] [Details]

Co-authors: Blizzard L; Taylor B; Tettey P; van der Mei I

Tweet

2013Taylor BV, Palmer A, Simpson Jr S, Lucas R, Simmons RD, et al., 'Assessing possible selection bias in a national voluntary MS longitudinal study in Australia', Multiple Sclerosis, 19, (12) pp. 1627-1631. ISSN 1352-4585 (2013) [Refereed Article]

DOI: 10.1177/1352458513481511 [eCite] [Details]

Citations: Scopus - 18Web of Science - 19

Co-authors: Taylor BV; Palmer A

Tweet

2013Palmer AJ, Hitchens PL, Simpson Jr S, O'Leary B, Colman S, et al., 'A novel method for calculating prevalence of multiple sclerosis in Australia', Multiple Sclerosis, 19, (13) pp. 1704-1711. ISSN 1352-4585 (2013) [Refereed Article]

DOI: 10.1177/1352458513479841 [eCite] [Details]

Citations: Scopus - 10Web of Science - 9

Co-authors: Palmer AJ; Hitchens PL; Taylor BV

Tweet

2012Simpson Jr S, 'Challenges in the detection and verification of acute infections in epidemiologic studies, and methods by which they can be overcome', Australasian Epidemiologist, 19.2 pp. 38-42. ISSN 1327-8835 (2012) [Non Refereed Article]

[eCite] [Details]

Tweet

2012Simpson Jr S, Taylor B, Dwyer DE, Taylor J, Blizzard L, et al., 'Anti-HHV-6 IgG titer significantly predicts subsequent relapse risk in multiple sclerosis', Multiple sclerosis journal, 18, (6) pp. 799-806. ISSN 1477-0970 (2012) [Refereed Article]

DOI: 10.1177/1352458511428081 [eCite] [Details]

Citations: Scopus - 20Web of Science - 20

Co-authors: Taylor B; Blizzard L; Pittas F; Van der Mei I

Tweet

2012Simpson Jr S, Taylor B, van der Mei I, 'A profile of the Multiple Sclerosis Longitudinal Study: Evaluating environmental, behavioural and genetic predictors of clinical outcomes in multiple sclerosis', Australasian Epidemiologist, 19, (2) pp. 33-37. ISSN 1327-8835 (2012) [Non Refereed Article]

[eCite] [Details]

Co-authors: Taylor B; van der Mei I

Tweet

2012Simpson Jr S, Turner R, 'Four decades of anal cancer in Tasmania, Australia: what do the case data tell us?', Sexual Health, 9, (3) pp. 213-219. ISSN 1448-5028 (2012) [Refereed Article]

DOI: 10.1071/SH11002 [eCite] [Details]

Citations: Scopus - 6Web of Science - 7

Co-authors: Turner R

Tweet

2012Stewart N, Simpson Jr S, van der Mei I, Ponsonby A-L, Blizzard L, et al., 'Interferon-β and serum 25-hydroxyvitamin D interact to modulate relapse risk in MS', Neurology, 79, (3) pp. 254-260. ISSN 0028-3878 (2012) [Refereed Article]

DOI: 10.1212/WNL.0b013e31825fded9 [eCite] [Details]

Citations: Scopus - 61Web of Science - 55

Co-authors: Stewart N; van der Mei I; Blizzard L; Pittas F; Taylor BV

Tweet

2012Trojano M, Lucchese G, Graziano G, Taylor BV, Simpson JR S, et al., 'Geographical variations in sex ratio trends over time in multiple sclerosis', PLoS ONE, 7, (10) Article e48078. ISSN 1932-6203 (2012) [Refereed Article]

DOI: 10.1371/journal.pone.0048078 [eCite] [Details]

Citations: Scopus - 95Web of Science - 87

Co-authors: Taylor BV

Tweet

2011Simpson Jr S, Blizzard L, Otahal P, Van der Mei I, Taylor B, 'Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis', Journal of Neurology, Neurosurgery and Psychiatry, 82, (10) pp. 1132-1141. ISSN 0022-3050 (2011) [Refereed Article]

DOI: 10.1136/jnnp.2011.240432 [eCite] [Details]

Citations: Scopus - 342Web of Science - 305

Co-authors: Blizzard L; Otahal P; Van der Mei I; Taylor B

Tweet

2011Simpson S, Pittas F, van der Mei I, Blizzard L, Ponsonby AL, et al., 'Trends in the epidemiology of multiple sclerosis in Greater Hobart, Tasmania: 1951 to 2009', Journal of Neurology, Neurosurgery and Psychiatry, 82, (2) pp. 180-187. ISSN 0022-3050 (2011) [Refereed Article]

DOI: 10.1136/jnnp.2010.215186 [eCite] [Details]

Citations: Scopus - 39Web of Science - 30

Co-authors: Pittas F; van der Mei I; Blizzard L; Taylor B

Tweet

2010Simpson S, Taylor B, Blizzard L, Ponsonby AL, Pittas F, et al., 'Higher 25-hydroxyvitamin D is associated with lower relapse risk in Multiple Sclerosis', Annals of Neurology, 68, (2) pp. 193-203. ISSN 0364-5134 (2010) [Refereed Article]

DOI: 10.1002/ana.22043 [eCite] [Details]

Citations: Scopus - 323Web of Science - 295

Co-authors: Taylor B; Blizzard L; Pittas F; van der Mei I

Tweet

2008Simpson Jr SL, Quirino JP, Terabe S, 'On-line sample preconcentration in capillary electrophoresis: Fundamentals and applications', Journal of Chromatography A, 1184, (1-2) pp. 504-541. ISSN 0021-9673 (2008) [Refereed Article]

DOI: 10.1016/j.chroma.2007.11.001 [eCite] [Details]

Citations: Scopus - 280Web of Science - 265

Co-authors: Quirino JP

Tweet

Review

(3 outputs)
YearCitationAltmetrics
2011Simpson Jr S, Greenhill K, Van der Mei I, Stankovich J, Charlesworth J, et al., 'The Varied Mechanisms of Vitamin D in the Onset and Clinical Course of MS: Potential Roles in Modulating Other Etiological Pathways', Current Medical Literature. Neurology, 27, (1) pp. 1-14. (2011) [Substantial Review]

[eCite] [Details]

Co-authors: Greenhill K; Van der Mei I; Stankovich J; Charlesworth J; Taylor BVM

2011Van der Mei IAF, Simpson JR S, Knippenberg S, Winzenberg T, Taylor BV, 'Role of vitamin D in multiple sclerosis: implications for disease management', Neurodegenerative Disease Management, 1, (6) pp. 523-536. (2011) [Substantial Review]

DOI: 10.2217/NMT.11.59 [eCite] [Details]

Co-authors: Van der Mei IAF; Winzenberg T; Taylor BV

Tweet

2011Van der Mei IAF, Simpson Jr S, Stankovich J, Taylor BV, 'Individual and Joint Action of Environmental Factors and Risk of MS', Neurologic Clinics , 29, (2) pp. 233-255. (2011) [Substantial Review]

DOI: 10.1016/j.ncl.2010.12.007 [eCite] [Details]

Citations: Scopus - 43Web of Science - 38

Co-authors: Van der Mei IAF; Stankovich J; Taylor BV

Tweet

Conference Publication

(1 outputs)
YearCitationAltmetrics
2015Zhou Y, Zhu GA, Nyholt DR, Charlesworth JC, Simpson JR Steve, et al., 'Multiple Quantitative Trait Loci for Anti-EBNA-1 IgG Titres are Associated with Risk of Multiple Sclerosis', Multiple Sclerosis Journal, pp. 810. ISSN 1352-4585 (2015) [Conference Extract]

[eCite] [Details]

Co-authors: Zhou Y; Zhu GA; Nyholt DR; Charlesworth JC; Van der Mei IAF; Taylor BVM

Grants & Funding

Steve has been successful in obtaining research funding to the amount of $681,474.

Funding Summary

Number of grants

12

Total funding

$881,089

Projects

Assessing the HR-HPV types in stored cervical excision samples for comparison with anal HR-HPV carriage in TasGANS (2016)$10,000
Description
We previously showed a significant association of post-toilet front-to-back and dabbing behaviours with occurrence of anal cancer precursors and cancer-causing HPV types. We want to substantiate the within-person autoinoculation route by comparing HR-HPV types present in stored cervical excision samples with those found in TasGANS anal samples.
Funding
Royal Hobart Hospital Research Foundation ($10,000)
Scheme
Grant-Starter
Administered By
University of Tasmania
Research Team
Simpson Jr S; Turner RC; Blomfield P; Tabrizi S
Year
2016
Does treating multiple sclerosis alter long-term disease outcomes? a natural history study (2016 - 2017)$180,000
Description
A natural history study of MS outcomes between a treated (Australian) versus untreated NZ population to study the long-term effects of MS disease modifying drugs. This is a clinical epidemiological project.
Funding
Multiple Sclerosis Research Australia ($180,000)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Taylor BVM; van der Mei IAF; Palmer AJ; Blizzard CL; Butzkueven H; Simpson Jr S; Kalincik T; Carroll W; Mason D
Period
2016 - 2017
DEVA MS: DEvelopment and VAlidation of a cost effectiveness simulation model for Multiple Sclerosis and implications for health policy (2015 - 2016)$160,000
Description
The number of people with multiple sclerosis (MS) is increasing dramatically in Australia, with rapidly escalating associated costs, both direct due to medical expenses and indirect due to lost or reduced employment. Existing and upcoming treatments for MS are expensive, with current prices of up to $25,000 per patient per year and rising. Using the best available data, this study will identify the treatments that are greatest value for money for the most common form of MS (relapsing-remitting MS), with a goal to reduce wastage of limited healthcare resources.
Funding
Multiple Sclerosis Research Australia ($160,000)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Palmer AJ; Taylor BVM; van der Mei IAF; Clarke Philip; Simpson Jr S
Period
2015 - 2016
Case-control study in Primary Progressive MS: Are the risk factors the same as for people with RRMS onset and can we identify new ones? (2015 - 2016)$142,000
Description
Examining risk factors of disease by comparing cases with a disease to healthy controls has been critical in understanding the aetiology of diseases. In MS, for example, important progress has been made through the epidemiological findings that cases were more likely to have had infectious mononucleosis, have high anti-EBNA IgG titres, and have low sun exposure levels. These findings resulted in a large body of laboratory work focusing on the mechanisms behind these observations. We have previously conducted epidemiological case-control studies on MS, but the number of people with PPMS was always too low to conduct a sub-analysis to examine whether the risk factors that we identified were also important in those with PPMS. We now propose to conduct a case-control of PPMS in a very cost-effective way, by using the data already collected on a large sample of healthy controls (n=558) from the Ausimmune study. We aim to collect the same data from a sample of cases with PPMS in Australia and compare that to the controls of the Ausimmune study. Moreover, the longer-term vision is that this data will form the basis for a prospective longitudinal study, where the cases with PPMS will be followed over time, in order to examine factors that are associated with the progression of MS. This will then be important for identifying possible treatments in MS for people with PPMS. HypothesesEstablished risk factors in MS, including low sun exposure, infectious mononucleosis, smoking, high anti-EBV-EBNA IgG and HLA-DR15 genotype are associated with an increased risk of PPMS onset.Low parity, lack of younger sibling exposure and exposure to livestock are associated with an increased risk of PPMS.People with PPMS have a higher EBV DNA load in whole blood and altered EBV serology compared to people with a RRMS onset.
Funding
Multiple Sclerosis Research Australia ($142,000)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
van der Mei IAF; Taylor BVM; Ponsonby AL; Lucas R; Simpson Jr S; Blizzard CL
Period
2015 - 2016
The relationship between Immunoglobulin E (IgE), disease severity and the immune response in multiple sclerosis (2014)$15,300
Description
The immune system in people with multiple sclerosis (MS) is thought to favour inflammatory responses that preclude allergic reactions and the production of the antibody Immunoglobulin E (IgE). This project proposes that IgE levels are in fact high in some people with MS, and that this is protective. It proposes therefore to measure IgE levels in persons with MS and examine associations between IgE, disease severity and immune function.
Funding
Royal Hobart Hospital Research Foundation ($15,300)
Scheme
Grant-Clinical Research
Administered By
University of Tasmania
Research Team
Taylor BVM; Stewart NJ; Simpson Jr S
Year
2014
Towards an algorithm for predicting the development and progression of multiple sclerosis utilising environmental and behavioural determinants (2013 - 2015)$240,000
Funding
Multiple Sclerosis Research Australia ($240,000)
Scheme
Fellowship-Postdoctoral
Administered By
University of Tasmania
Research Team
Simpson Jr S
Period
2013 - 2015
Examining the role of blood lipids and apolipoproteins on the progression of MS in a prospective clinical cohort (2013)$22,109
Funding
Royal Hobart Hospital Research Foundation ($22,109)
Scheme
Grant-Clinical Research
Administered By
University of Tasmania
Research Team
Taylor BVM; van der Mei IAF; Lucas R; Kostner K; Simpson Jr S
Year
2013
The Cholecalciferol Intervention to Prevent Respiratory Infections Study (CIPRIS) (2012)$6,335
Funding
The Select Foundation ($6,335)
Scheme
Grant-Small Grants Scheme
Administered By
University of Tasmania
Research Team
Simpson Jr S; Taylor BVM; Stewart NJ; van der Mei IAF; Blizzard CL
Year
2012
The Tasmanian Gynaecological & Anal Neoplasia Study (TasGANS) (Northern Tasmania) (2012 - 2015)$61,998
Funding
Clifford Craig Foundation ($37,038)
Scheme
Grant
Administered By
University of Tasmania
Research Team
Turner RC; Dennis AE; Simpson Jr S
Period
2012 - 2015
A double-blind randomised controlled trial to evaluate the efficacy of 20,000 IU/wk cholecalciferol in reducing respiratory tract infection in a cohort of healthy young adults (2012)$22,256
Funding
Royal Hobart Hospital Research Foundation ($22,256)
Scheme
Grant-Clinical Research
Administered By
University of Tasmania
Research Team
Taylor BVM; Simpson Jr S; van der Mei IAF; Stewart NJ
Year
2012
The effect of vitamin D and Interferon-beta on the immune response (2012)$9,091
Funding
Royal Hobart Hospital Research Foundation ($9,091)
Scheme
Grant-Starter
Administered By
University of Tasmania
Research Team
Taylor BVM; Stewart NJ; Simpson Jr S
Year
2012
The Tasmanian Women's Anal Neoplasia study (TasWAN) (2011)$12,000
Funding
Cancer Council of Tasmania ($12,000)
Scheme
Grant-Small
Administered By
University of Tasmania
Research Team
Turner RC; Blomfield P; O'Sullivan M; Simpson Jr S
Year
2011

Research Supervision

Current

3

Completed

5

Current

DegreeTitleCommenced
PhDImproving the Lives of People with Multiple Sclerosis2015
PhDRisk Factors for People with Primary Progressive Multiple Sclerosis2016
PhDThe Role of Diet on Clinical Course in Multiple Sclerosis2019

Completed

DegreeTitleCompleted
PhDAssociations Between Environmental or Behavioural Factors and Natural History of MS
Candidate: Chunrong Tao
2018
MastersOn the Role of Risk-Associated Genetic Loci in Modulating Clinical Course in Multiple Sclerosis
Candidate: Gongbu Pan
2016
PhDIdentifying Genetic Variants and Environmental Factors Influencing Multiple Sclerosis Pathological Processes
Candidate: Yuan Zhou
2016
PhDThe Role of Serum Lipid Profile and Comorbidities in the Onset and Progression of Multiple Sclerosis
Candidate: Prudence Tettey
2016
PhDDissecting the Genetics Architecture of Multiple Sclerosis
Candidate: Rui Lin
2014