Nicole Bye

UTAS Home Dr Nicole Bye

Nicole Bye

Lecturer in Pharmacology

Room 4011 , Pharmacy

+61 6226 1032 (phone)

Dr Bye is a lecturer in the school of medicine, teaching neuroscience and pharmacology. Her research focuses on cellular regeneration after traumatic brain injury, as well as imaging techniques and quantitative approaches to measure inflammation and cellular repair in the aftermath of injury. Prior to her current position Dr Bye held a series of fellowships during her extensive experience in laboratory neuroscience research, and maintains collaborations around Australia. She is also an experienced research mentor at undergraduate and postgraduate levels.


During an eleven-year term as a research scientist in the laboratory of the National Trauma Research Institute at the Alfred Hospital, Dr Bye completed her PhD working with A/Prof Cristina Morganti-Kossmann, establishing a range of advanced imaging techniques and animal models of brain injury. Following her PhD she was awarded an Early Career Researcher Fellowship by the Victorian Neurotrauma Initiative, before securing half a million dollars in funding from the Transport Accident Commission to investigate the possibility of post-injury regeneration by stimulating the birth of new neurons.

Career summary


  • PhD (Monash University), 2006. Thesis: Gene expression and effects of TGF-ß1 in relation to apoptosis and neurogenesis in adult rat hippocampus.
  • BSc(Hons) (Monash University)


Professional practice

  • Australasian Neuroscience Society
  • International Neurotrauma Society

Administrative expertise

  • Dr Bye coordinates units and is part of the management team for the Bachelor of Pharmacy.


Pharmacology of the ANS, CNS and immune system; neuroscience; brain injury; neuroinflammation; regeneration; research methodology and project design

Teaching responsibility

Unit Coordinator


View more on Dr Nicole Bye in WARP


  • animal models of traumatic brain injury
  • neuroinflammation
  • post-traumatic neurogenesis

Research Themes

Dr Bye is a nationally prominent researcher in the field of traumatic brain injury (TBI). TBI represents a considerable and life-changing burden to the people injured, their families and friends, and the health care system. Recovery from TBI is often slow and difficult, and in many cases individuals are left with a permanent loss of function. This is because the brain heals very differently to other body tissues, and the process of rebuilding is not yet well understood. Her research focuses on regenerative responses after traumatic brain injury, with a particular interest in the role of neuroinflammation in regulating neurogenesis in the injured cortex. Guiding and shaping this process to produce useful functional replacements is a major goal for successful rehabilitation. She is also investigating the therapeutic potential of novel anti-inflammatory drugs being developed by collaborators in the division of Pharmacy.

Her work employs a range of techniques including the pioneering use of nanoparticles as inflammatory markers, drug discovery and evaluation, small animal MRI, confocal microscopy and unbiased tissue quantitation methods. In addition to her technical expertise, she has extensive experience in undergraduate and postgraduate research supervision.

Dr Bye’s research aligns to the University’s research theme of Better Health.


  • Awarded an Adjunct Senior Research Fellow position with the Department of Surgery, Monash University, April 2013 – March 2014
  • Awarded an Early Career Researcher Fellowship from the Victorian Neurotrauma Initiative, February 2009 – January 2012

Fields of Research

  • Central nervous system (320903)
  • Nanobiotechnology (310607)
  • Neurosciences (320999)
  • Neurology and neuromuscular diseases (320905)
  • Pharmaceutical sciences (321405)
  • Biologically active molecules (340401)
  • Receptors and membrane biology (310110)
  • Cellular nervous system (320902)
  • Basic pharmacology (321401)
  • Cardiology (incl. cardiovascular diseases) (320101)
  • Cellular immunology (320404)

Research Objectives

  • Clinical health (200199)
  • Expanding knowledge in the health sciences (280112)
  • Treatment of human diseases and conditions (200105)
  • Efficacy of medications (200102)
  • Human biological preventatives (240801)
  • Behaviour and health (200401)
  • Expanding knowledge in the biomedical and clinical sciences (280103)
  • Expanding knowledge in the biological sciences (280102)
  • Diagnosis of human diseases and conditions (200101)


Total publications


Journal Article

(20 outputs)
2021Daniel A, Premilovac D, Foa L, Feng ZK, Shah K, et al., 'Novel short-chain quinones to treat vision loss in a rat model of diabetic retinopathy', International Journal of Molecular Sciences, 22, (3) Article 1016. ISSN 1422-0067 (2021) [Refereed Article]

DOI: 10.3390/ijms22031016 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Daniel A; Premilovac D; Foa L; Feng ZK; Shah K; Woolley KL; Smith Jason Alfred; Gueven N


2020Collins JM, Woodhouse A, Bye N, Vickers JC, King AE, et al., 'Pathological links between traumatic brain injury and dementia: Australian pre-clinical research', Journal of Neurotrauma, 37, (5) pp. 782-791. ISSN 0897-7151 (2020) [Refereed Article]

DOI: 10.1089/neu.2019.6906 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Collins JM; Woodhouse A; Vickers JC; King AE; Ziebell JM


2020Ferreira SC, Pitman KA, Wang S, Summers BS, Bye N, et al., 'Amyloidosis is associated with thicker myelin and increased oligodendrogenesis in the adult mouse brain', Journal of Neuroscience Research pp. 1-28. ISSN 0360-4012 (2020) [Refereed Article]

DOI: 10.1002/jnr.24672 [eCite] [Details]

Citations: Scopus - 6Web of Science - 6

Co-authors: Ferreira SC; Pitman KA; Wang S; Summers BS; Young KM; Cullen CL


2019Morganti-Kossmann MC, Semple BD, Hellewell SC, Bye N, Ziebell JM, 'The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments', Acta Neuropathologica, 137 pp. 731-755. ISSN 0001-6322 (2019) [Refereed Article]

DOI: 10.1007/s00401-018-1944-6 [eCite] [Details]

Citations: Scopus - 79Web of Science - 75

Co-authors: Ziebell JM


2018Hellewell SC, Mondello S, Conquest A, Shaw G, Madorsky I, et al., 'Erythropoietin Does Not Alter Serum Profiles of Neuronal and Axonal Biomarkers After Traumatic Brain Injury: Findings From the Australian EPO-TBI Clinical Trial', Critical care medicine, 46, (4) pp. 554-561. ISSN 0090-3493 (2018) [Refereed Article]

DOI: 10.1097/CCM.0000000000002938 [eCite] [Details]

Citations: Web of Science - 59


2017Nhiem Tran N, Bye N, Moffat BA, Wright DK, Cuddihy A, et al., 'Dual-modality NIRF-MRI cubosomes and hexosomes: High throughput formulation and in vivo biodistribution', Materials Science & Engineering C-Materials for Biological Applications, 71 pp. 584-593. ISSN 0928-4931 (2017) [Refereed Article]

DOI: 10.1016/j.msec.2016.10.028 [eCite] [Details]

Citations: Scopus - 45Web of Science - 41


2017Woodcock TM, Frugier T, Nguyen TT, Semple BD, Bye N, et al., 'The scavenging chemokine receptor ACKR2 has a significant impact on acute mortality rate and early lesion development after traumatic brain injury', PLoS one, 12, (11) Article e0188305. ISSN 1932-6203 (2017) [Refereed Article]

DOI: 10.1371/journal.pone.0188305 [eCite] [Details]

Citations: Scopus - 9Web of Science - 9


2016Basrai HS, Christie KJ, Turbic A, Bye N, Turnley AM, 'Suppressor of cytokine Signaling-2 (SOCS2) regulates the microglial response and improves functional outcome after traumatic brain injury in mice', PloS One, 11, (14) Article e0153418. ISSN 1932-6203 (2016) [Refereed Article]

DOI: 10.1371/journal.pone.0153418 [eCite] [Details]

Citations: Scopus - 20Web of Science - 20


2016Bye N, Christie KJ, Turbic A, Basrai HS, Turnley AM, 'Rho kinase inhibition following traumatic brain injury in mice promotes functional improvement and acute neuron survival but has little effect on neurogenesis, glial responses or neuroinflammation', Experimental Neurology, 279 pp. 86-95. ISSN 0014-4886 (2016) [Refereed Article]

DOI: 10.1016/j.expneurol.2016.02.012 [eCite] [Details]

Citations: Scopus - 11Web of Science - 13


2016Frugier T, Taylor JM, McLean C, Bye N, Beart PM, et al., 'Evidence for the recruitment of autophagic vesicles in human brain after stroke', Neurochemistry international, 96 pp. 62-68. ISSN 0197-0186 (2016) [Refereed Article]

DOI: 10.1016/j.neuint.2016.02.016 [eCite] [Details]

Citations: Scopus - 13Web of Science - 12


2015Dent KA, Christie KJ, Bye N, Basrai HS, Turbic A, et al., 'Oligodendrocyte birth and death following traumatic brain injury in adult mice', PloS one, 10, (3) Article e0121541. ISSN 1932-6203 (2015) [Refereed Article]

DOI: 10.1371/journal.pone.0121541 [eCite] [Details]

Citations: Scopus - 38Web of Science - 39


2014Bye N, Hutt OE, Hinton TM, Acharya DP, Waddington LJ, et al., 'Nitroxide-loaded hexosomes provide MRI contrast in vivo', Langmuir, 30, (29) pp. 8898-8906. ISSN 0743-7463 (2014) [Refereed Article]

DOI: 10.1021/la5007296 [eCite] [Details]

Citations: Scopus - 39Web of Science - 39


2014Goh CP, Putz U, Howitt J, Low LH, Gunnersen J, et al., 'Nuclear trafficking of Pten after brain injury leads to neuron survival not death', Experimental neurology, 252 pp. 37-46. ISSN 0014-4886 (2014) [Refereed Article]

DOI: 10.1016/j.expneurol.2013.11.017 [eCite] [Details]

Citations: Scopus - 20Web of Science - 21


2014Tarlac V, Kelly L, Anderson RP, Bye N, Storey E, 'Coeliac disease patients do not produce antibodies to a common cerebellar epitope', Cerebellum & Ataxias, 1 Article 18. ISSN 2053-8871 (2014) [Refereed Article]

DOI: 10.1186/s40673-014-0018-3 [eCite] [Details]


2014Yan EB, Satgunaseelan L, Paul E, Bye N, Nguyen P, et al., 'Post-Traumatic Hypoxia Is Associated with Prolonged Cerebral Cytokine Production, Higher Serum Biomarker Levels, and Poor Outcome in Patients with Severe Traumatic Brain Injury', Journal of Neurotrauma, 31, (7) pp. 618-629. ISSN 0897-7151 (2014) [Refereed Article]

DOI: 10.1089/neu.2013.3087 [eCite] [Details]

Citations: Scopus - 63Web of Science - 63


2013Hellewell S, Yan EB, Alwis DS, Bye N, Morganti-Kossmann MC, 'Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor', Journal of Neuroinflammation, 10 pp. 1-21. ISSN 1742-2094 (2013) [Refereed Article]

DOI: 10.1186/1742-2094-10-156 [eCite] [Details]

Citations: Scopus - 45Web of Science - 44


2012Bye N, Turnley AM, Morganti-Kossmann C, 'Inflammatory Regulators of Redirected Neural Migration in the Injured Brain', Neurosignals, 20, (3) pp. 132-146. ISSN 1424-862X (2012) [Refereed Article]

DOI: 10.1159/000336542 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8


2012Ng SY, Semple BD, Morganti-Kossman MC, Bye N, 'Attenuation of Microglial Activation with Minocycline Is Not Associated with Changes in Neurogenesis after Focal Traumatic Brain Injury in Adult Mice', Journal of neurotrauma, 29, (7) pp. 1410-1425. ISSN 0897-7151 (2012) [Refereed Article]

DOI: 10.1089/neu.2011.2188 [eCite] [Details]

Citations: Scopus - 45Web of Science - 42


2011Bye N, Carron S, Han X, Aqyapomaa D, Ng SY, et al., 'Neurogenesis and Glial Proliferation Are Stimulated Following Diffuse Traumatic Brain Injury in Adult Rats', Journal of neuroscience research, 89, (7) pp. 986-1000. ISSN 0360-4012 (2011) [Refereed Article]

DOI: 10.1002/jnr.22635 [eCite] [Details]

Citations: Scopus - 65Web of Science - 63


2011Ziebell JM, Bye N, Semple BD, Kossmann T, Morganti-Kossmann MC, 'Attenuated neurological deficit, cell death and lesion volume in Fas-mutant mice is associated with altered neuroinflammation following traumatic brain injury', Brain research, 1414 pp. 94-105. ISSN 0006-8993 (2011) [Refereed Article]

DOI: 10.1016/j.brainres.2011.07.056 [eCite] [Details]

Citations: Scopus - 36Web of Science - 35

Co-authors: Ziebell JM


Grants & Funding

Funding Summary

Number of grants


Total funding



Acquisition of a VS200 Research Slide Scanner for the College of Health and Medicine (2022)$100,000
The Olympus VS200 Research Slide Scanner enables the imaging of entire tissue sections in an automated manner. It can acquire images from up to six fluorescent channels along with brightfield, dark field and phase contrast, and has objectives up to 100X. The robotic slide loader allows for batch scanning of up to 210 slides at a time and can accommodate multiple sizes of slides up to 4x5 plates for large tissue sections. Our current VS120 slide scanner is already used at a maximum capacity with researchers having to book weeks in advance to scan slides. The VS200 will add further capacity and offers improved capabilities with greater optical resolution, more fluorescent channels, more batch scanning capacity and the ability to scan larger slides. Pairing this with free open source software like QuPath provides high throughput, efficient and highly accurate quantitative workflows that greatly improve productivity.
Ian Potter Foundation ($100,000)
Grant - Medical Research
Administered By
University of Tasmania
Research Team
Sutherland BA; Howells DW; Courtney J; King AE; Dickson TC; Premilovac D; Bye N; Flies AS; Young K
Investigating the anti-inflammatory effect of a non-anticoagulant molecule of heparin following experimental traumatic brain injury (2017)$10,000
Heparin has shown promising results in attenuating neuroinflammation following experimental traumatic brain injury (TBI); however, its anti-coagulative properties make it an unsuitable treatment due to the risk of bleeding. We have recently shown that the heparin derivative Dp4 retains the anti-inflammatory actions of heparin, but not the anti-coagulative properties. In this project, we will test whether Dp4 suppresses neuroinflammation following TBI in mice, potentially identifying it as a novel and valuable therapeutic agent for brain-injured patients.
Royal Hobart Hospital Research Foundation ($10,000)
Administered By
University of Tasmania
Research Team
Bye N; Taylor BVM; Patel RP

Research Supervision






PhDInvestigating the Therapeutic Efficacy of Non-anticoagulant Fractions (Dp2 and Dp4) of Enoxaparin following Experimental Traumatic Brain Injury2017
PhDDoes Obesity Exacerbate Neuroinflammation and Alter the Efficacy of Anti-inflammatory Treatment Following Experimental TBI?2020
PhDExploring the Role of Adrenergic Signalling and Therapeutic Effects of 2 - Adrenergic Agonists in Traumatic Brain Injury2021


PhDPharmacological Modulation of Mood, Behaviour and Cognition
Candidate: Xin Yin