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Jane Alty

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Jane Alty

Senior Lecturer in Neurology

Medical Sciences 1, Level 4 , Hobart CBD Campuses

Dr Alty is a medically qualified Neurology Consultant and early career researcher. Her inter-disciplinary research focuses on motor biomarkers and the development of computer-aided devices to improve the diagnostic accuracy of neurodegenerative disorders.  She was employed in the UK National Health Service (NHS) for 18 years until 2019, when she was recruited by the University of Tasmania as an academic neurologist. Dr Alty is now a Senior Lecturer in Neurology at the Wicking Dementia Centre and Neurologist at RHH. She also holds an Honorary Senior Lecturer position at Hull York Medical School, University of York, and an Honorary Consultant Neurologist research position at Leeds Teaching Hospitals NHS Trust. Since joining UTAS, Dr Alty has brought together a new research team between the Wicking Centre and the ICT and Psychology departments, to develop 'TasTest' - a new online tool that aims to discriminate healthy ageing from early dementia. She has also been involved in research involving the Tasmanian Healthy Brain Project and the ISLAND Project, examining minimally-invasive and non-invasive biomarkers of early Alzheimer's disease. She has been instrumental in developing the new multi-disciplinary ISLAND cognitive clinic to provide the Tasmanian community with a gold-standard diagnostic clinic service.

Biography

Dr Alty qualified from the University of Cambridge, UK, and ranked top of her year in the final surgical written and clinical exams. She completed general medicine training in Cambridge, Leeds and Manchester. She passed all 3 postgraduate medical examinations on first attempts and was awarded Membership of the Royal College of Physicians London in 2003. She completed Neurology specialist training in London and Leeds, and a Movement Disorder Fellowship in Monash Medical Centre, Melbourne. In 2013, she was appointed Consultant Neurologist at the West Yorkshire Regional Neurosciences centre. Dr Alty was awarded an MD doctorate by the University of York for research examining how computer technologies and movement analysis can aid discrimination of Parkinson’s disease and healthy ageing. She was awarded Fellowship of the Royal College of Physicians London in 2017 and won Clinical Excellence Awards for outstanding clinical contributions in 2016, 2017 and 2018. She played an instrumental role in an NHS Parkinson’s team quality improvement project that was awarded 2 competitive national UK awards: Parkinson’s Excellence 2018 and the Health Service Journal Patient Collaboration Award 2019. She has locally led 6 clinical trials in neurodegenerative disorders. She led her centre to be the highest recruiting group in the UK for one of these studies and 5th out of 54 worldwide.

Career summary

Qualifications

  • FRCP, Fellowship of  the Royal College of Physicians London, 2017
  • MD, University of York, 2014 Thesis: Objective evaluation of Parkinson's bradykinesia
  • MRCP, Membership of the Royal College of Physicians London, 2003
  • MA (Cantab.), University of Cambridge, 2001
  • MB BChir, University of Cambridge, 2000
  • BA (Hons), University of Cambridge, 1997

View more on Dr Jane Alty in WARP

Fields of Research

  • Neurology and neuromuscular diseases (320905)
  • Central nervous system (320903)
  • Geriatrics and gerontology (320210)
  • Computer vision (460304)
  • Health services and systems (420399)
  • Cognitive neuroscience (520203)
  • Radiology and organ imaging (320222)
  • Health management (420309)
  • Neurosciences (320999)
  • Preventative health care (420605)
  • Applications in health (460102)
  • Digital health (420302)
  • Clinical sciences (320299)
  • Medical biotechnology (320699)
  • Diagnostic radiography (320206)
  • Health informatics and information systems (420308)
  • Health promotion (420603)
  • Evolutionary computation (460203)
  • Cardiology (incl. cardiovascular diseases) (320101)
  • Peripheral nervous system (320906)
  • Oral and maxillofacial surgery (320305)
  • People with disability (420318)
  • Primary health care (420319)
  • Epidemiology (420299)
  • Behavioural neuroscience (520202)
  • Artificial intelligence (460299)
  • Cognition (520401)
  • Human-computer interaction (460806)
  • Sensor technology (incl. chemical aspects) (340108)
  • Virtual and mixed reality (460708)
  • Analytical biochemistry (310101)
  • Satisfiability and optimisation (460210)
  • Motor control (420703)
  • Computational neuroscience (incl. mathematical neuroscience and theoretical neuroscience) (320904)
  • Speech recognition (460212)
  • Intensive care (320212)

Research Objectives

  • Clinical health (200199)
  • Diagnosis of human diseases and conditions (200101)
  • Treatment of human diseases and conditions (200105)
  • Artificial intelligence (220403)
  • Preventive medicine (200412)
  • Health related to ageing (200502)
  • Mental health (200409)
  • Efficacy of medications (200102)
  • Behaviour and health (200401)
  • Health education and promotion (200203)
  • Evaluation of health and support services (200299)
  • Outpatient care (200308)
  • Palliative care (200309)
  • Telehealth (200208)
  • Allied health therapies (excl. mental health services) (200301)
  • Health policy evaluation (200205)
  • Injury prevention and control (200408)
  • Human-computer interaction (220407)
  • Other health (209999)
  • Health inequalities (200204)
  • Public health (excl. specific population health) (200499)
  • Expanding knowledge in the information and computing sciences (280115)
  • Prevention of human diseases and conditions (200104)
  • Expanding knowledge in psychology (280121)
  • Information systems, technologies and services (220499)

Publications

Total publications

63

Journal Article

(45 outputs)
YearCitationAltmetrics
2021Alissa M, Lones MA, Cosgrove J, Alty JE, Jamieson S, et al., 'Parkinson's disease diagnosis using convolutional neural networks and figure-copying tasks', Neural Computing and Applications ISSN 0941-0643 (2021) [Refereed Article]

DOI: 10.1007/s00521-021-06469-7 [eCite] [Details]

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2021Bindoff AD, Summers MJ, Hill E, Alty J, Vickers JC, 'Studying at university in later life slows cognitive decline: A long-term prospective study', Alzheimer's & Dementia: Translational Research & Clinical Interventions pp. 1-10. ISSN 2352-8737 (2021) [Refereed Article]

DOI: 10.1002/trc2.12207 [eCite] [Details]

Co-authors: Bindoff AD; Hill E; Vickers JC

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2021Collins JM, Hill E, Bindoff A, King AE, Alty J, et al., 'Association Between Components of Cognitive Reserve and Serum BDNF in Healthy Older Adults', Frontiers in Aging Neuroscience, 13 pp. 1-9. ISSN 1663-4365 (2021) [Refereed Article]

DOI: 10.3389/fnagi.2021.725914 [eCite] [Details]

Co-authors: Collins JM; Hill E; Bindoff A; King AE; Summers MJ; Vickers JC

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2021Cosgrone J, Hinder MR, St George RJ, Picardi C, Smith SL, et al., 'Significant cognitive decline in Parkinson's disease exacerbates the reliance on visual feedback during upper limb reaches', Neuropsychologia, 157 Article 107885. ISSN 0028-3932 (2021) [Refereed Article]

DOI: 10.1016/j.neuropsychologia.2021.107885 [eCite] [Details]

Co-authors: Hinder MR; St George RJ

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2021Dosanjh M, Alty J, Martin C, Latchford G, Graham CD, 'What is it like to live with a functional movement disorder? An interpretative phenomenological analysis of illness experiences from symptom onset to post-diagnosis', British Journal of Health Psychology, 26, (2) pp. 325-342. ISSN 1359-107X (2021) [Refereed Article]

DOI: 10.1111/bjhp.12478 [eCite] [Details]

Citations: Scopus - 1

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2021Tucker H, Osei-Poku F, Ashton D, Lally R, Jesuthasan A, et al., 'Management of secondary poor response to botulinum toxin in cervical dystonia: a multicenter audit', Movement Disorders Clinical Practice, 8, (4) pp. 541-545. ISSN 2330-1619 (2021) [Refereed Article]

DOI: 10.1002/mdc3.13181 [eCite] [Details]

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2021Varma P, Narayan L, Alty J, Painter V, Padmakumar C, 'An innovative personalised management program for older adults with Parkinson's disease: new concepts and future directions', Journal of Personalized Medicine, 11, (1) Article 43. ISSN 2075-4426 (2021) [Refereed Article]

DOI: 10.3390/jpm11010043 [eCite] [Details]

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2021Wang X, Garg S, Tran SN, Bai Q, Alty J, 'Hand tremor detection in videos with cluttered background using neural network based approaches', Health Information Science and Systems, 9, (1) pp. 1-14. ISSN 2047-2501 (2021) [Refereed Article]

DOI: 10.1007/s13755-021-00159-3 [eCite] [Details]

Co-authors: Wang X; Garg S; Tran SN; Bai Q

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2021Williams S, Fang H, Relton SD, Wong DC, Alam T, et al., 'Accuracy of smartphone video for contactless measurement of hand tremor frequency', Movement Disorders Clinical Practice, 8, (1) pp. 69-75. ISSN 2330-1619 (2021) [Refereed Article]

DOI: 10.1002/mdc3.13119 [eCite] [Details]

Citations: Web of Science - 1

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2020Alty J, Farrow M, Lawler K, 'Exercise and dementia prevention', Practical Neurology, 20, (3) pp. 234-240. ISSN 1474-7758 (2020) [Refereed Article]

DOI: 10.1136/practneurol-2019-002335 [eCite] [Details]

Citations: Scopus - 8

Co-authors: Farrow M; Lawler K

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2020Britton D, Alty JE, Mannion CJ, 'Oromandibular dystonia: a diagnosis not to miss', British Journal of Oral and Maxillofacial Surgery, 58, (5) pp. 520-524. ISSN 0266-4356 (2020) [Refereed Article]

DOI: 10.1016/j.bjoms.2020.02.018 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

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2020Corrado J, Jackson O, Baxandall D, Robson J, Duggan-Carter P, et al., 'Get Parkinson's medications on time: the Leeds QI project', Age and Ageing, 49, (5) pp. 865-872. ISSN 0002-0729 (2020) [Refereed Article]

DOI: 10.1093/ageing/afaa142 [eCite] [Details]

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2020Williams S, Fang H, Relton SD, Graham CD, Alty JE, 'Seeing the unseen: could Eulerian video magnification aid clinician detection of subclinical Parkinson's tremor?', Journal of Clinical Neuroscience, 81 pp. 101-104. ISSN 0967-5868 (2020) [Refereed Article]

DOI: 10.1016/j.jocn.2020.09.046 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2020Williams S, Relton SD, Fang H, Alty J, Qahwaji R, et al., 'Supervised classification of bradykinesia in Parkinson's disease from smartphone videos', Artificial Intelligence in Medicine, 110 Article 101966. ISSN 0933-3657 (2020) [Refereed Article]

DOI: 10.1016/j.artmed.2020.101966 [eCite] [Details]

Citations: Scopus - 2Web of Science - 1

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2020Williams S, Zhao Z, Hafeez A, Wong DC, Relton SD, et al., 'The discerning eye of computer vision: can it measure Parkinson's finger tap bradykinesia?', Journal of The Neurological Sciences, 416 Article 117003. ISSN 0022-510X (2020) [Refereed Article]

DOI: 10.1016/j.jns.2020.117003 [eCite] [Details]

Citations: Scopus - 7Web of Science - 4

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2019Khan S, Sivakumar G, Currie S, Alty J, 'Multiple system atrophy mimicked by multi-organ pathology', Practical Neurology ISSN 1474-7758 (2019) [Contribution to Refereed Journal]

DOI: 10.1136/practneurol-2019-002233 [eCite] [Details]

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2019Nagao K, Ding C, Ganga G, Alty JE, Clissold BG, et al., 'Inferring the long duration response to levodopa in Parkinson's disease', Parkinsonism and Related Disorders, 60 pp. 133-137. ISSN 1353-8020 (2019) [Refereed Article]

DOI: 10.1016/j.parkreldis.2018.09.002 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

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2019Smith N, Kimberger K, Parrish C, Currie S, Butterworth S, et al., 'Multiple plasmacytoma with multiple neurological presentations: A difficult case', Practical Neurology ISSN 1474-7758 (2019) [Contribution to Refereed Journal]

DOI: 10.1136/ practneurol-2019-002205 [eCite] [Details]

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2019Thorpe DE, Alty JE, Kempster PA, 'Health at the writing desk of John Ruskin: a study of handwriting and illness', Medical Humanities, 46, (1) pp. 31-45. ISSN 1468-215X (2019) [Refereed Article]

DOI: 10.1136/medhum-2018-011600 [eCite] [Details]

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2019Williams S, Shepherd S, Fang H, Alty J, O'Gorman P, et al., 'Computer vision of smartphone video has potential to detect functional tremor', Journal of the Neurological Sciences, 401 pp. 27-28. ISSN 0022-510X (2019) [Letter or Note in Journal]

DOI: 10.1016/j.jns.2019.04.016 [eCite] [Details]

Citations: Scopus - 2Web of Science - 2

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2018Cosgrove J, Alty JE, 'Cognitive deficits in Parkinson's disease: current perspectives', Journal of Parkinsonism and Restless Legs Syndrome, 8 pp. 1-11. ISSN 1927-7725 (2018) [Refereed Article]

DOI: 10.2147/JPRLS.S125064 [eCite] [Details]

Citations: Web of Science - 2

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2018Gao C, Smith S, Lones M, Jamieson S, Alty J, et al., 'Objective assessment of bradykinesia in Parkinson's disease using evolutionary algorithms: Clinical validation', Translational Neurodegeneration, 7, (18) ISSN 2047-9158 (2018) [Refereed Article]

DOI: 10.1186/s40035-018-0124-x [eCite] [Details]

Citations: Scopus - 19Web of Science - 19

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2018Williams S, Fang H, Alty J, Qahwaji R, Patel P, et al., 'A smartphone camera reveals an 'invisible' Parkinsonian tremor: A potential pre-motor biomarker?', Journal of Neurology, 265, (12) pp. 3017-3018. ISSN 0340-5354 (2018) [Letter or Note in Journal]

DOI: 10.1007/s00415-018-9060-z [eCite] [Details]

Citations: Scopus - 3Web of Science - 2

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2017Alty J, Cosgrove J, Thorpe D, Kempster P, 'How to use pen and paper tasks to aid tremor diagnosis in the clinic', Practical Neurology, 17, (6) pp. 456-463. ISSN 1474-7758 (2017) [Refereed Article]

DOI: 10.1136/practneurol-2017-001719 [eCite] [Details]

Citations: Scopus - 14

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2017Lones MA, Alty JE, Cosgrove J, Duggan-Carter P, Jamieson S, et al., 'A new evolutionary algorithm-based home monitoring device for Parkinson's dyskinesia', Journal of Medical Systems, 41, (176) pp. 1-8. ISSN 0148-5598 (2017) [Refereed Article]

DOI: 10.1007/s10916-017-0811-7 [eCite] [Details]

Citations: Scopus - 6Web of Science - 5

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2017Newby RE, Thorpe DE, Kempster PA, Alty JE, 'A history of dystonia: Ancient to modern', Movement Disorders Clinical Practice, 4, (4) pp. 478-485. ISSN 2330-1619 (2017) [Refereed Article]

DOI: 10.1002/mdc3.12493 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

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2017Shanmugarajah PD, Alty J, Lily O, Ford HL, 'Lesson of the month 2: Transient reversible amnesia in multiple sclerosis', Clinical Medicine, 17, (1) pp. 88-90. ISSN 1470-2118 (2017) [Contribution to Refereed Journal]

DOI: 10.7861/clinmedicine.17-1-88 [eCite] [Details]

Citations: Scopus - 1

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2016Alty J, Robson J, Duggan-Carter P, Jamieson S, 'What to do when people with Parkinson's disease cannot take their usual oral medications', Practical Neurology, 16, (2) pp. 122-128. ISSN 1474-7758 (2016) [Refereed Article]

DOI: 10.1136/practneurol-2015-001267 [eCite] [Details]

Citations: Scopus - 13

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2016Ding C, Ganesvaran G, Alty JE, Clissold BG, McColl CD, et al., 'Study of levodopa response in Parkinson's disease: observations on rates of motor progression', Movement Disorders, 31, (4) pp. 589-592. ISSN 0885-3185 (2016) [Refereed Article]

DOI: 10.1002/mds.26497 [eCite] [Details]

Citations: Scopus - 8Web of Science - 8

Co-authors: Srikanth V

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2016Turner AP, Lones MA, Trefzer MA, Smith SL, Jamieson S, et al., 'Using epigenetic networks for the analysis of movement associatedwith levodopa therapy for Parkinson's disease', Biosystems, 146 pp. 35-42. ISSN 0303-2647 (2016) [Refereed Article]

DOI: 10.1016/j.biosystems.2016.05.005 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2015Alty JE, Cosgrove J, Jamieson S, Smith SL, Possin KL, 'Which figure copy test is more sensitive for cognitive impairment in Parkinson's disease: Wire cube or interlocking pentagons?', Clinical Neurology and Neurosurgery, 139 pp. 244-246. ISSN 0303-8467 (2015) [Refereed Article]

DOI: 10.1016/j.clineuro.2015.10.019 [eCite] [Details]

Citations: Scopus - 5Web of Science - 5

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2015Cosgrove J, Alty JE, Jamieson S, 'Cognitive impairment in Parkinson's disease', Postgraduate Medical Journal, 91, (1074) pp. 212-220. ISSN 0032-5473 (2015) [Refereed Article]

DOI: 10.1136/postgradmedj-2015-133247 [eCite] [Details]

Citations: Scopus - 39Web of Science - 33

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2015Newby R, Jamieson S, Udd B, Alty J, 'When myopathy breaks the rules: A late-onset distal presentation', BMJ Case Reports, 2015 pp. bcr2015209436. ISSN 1757-790X (2015) [Contribution to Refereed Journal]

DOI: 10.1136/bcr-2015-209436 [eCite] [Details]

Citations: Scopus - 2

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2015Smith SL, Lones MA, Bedder M, Alty JE, Cosgrone J, et al., 'Computational approaches for understanding the diagnosis and treatment of Parkinson's disease', IET Systems Biology, 9, (6) pp. 226-233. ISSN 1751-8849 (2015) [Refereed Article]

DOI: 10.1049/iet-syb.2015.0030 [eCite] [Details]

Citations: Scopus - 12Web of Science - 10

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2015Thorpe DE, Alty JE, 'What type of tremor did the medieval 'Tremulous Hand of Worcester' have?', Brain, 138, (10) pp. 3123-3127. ISSN 0006-8950 (2015) [Refereed Article]

DOI: 10.1093/brain/awv232 [eCite] [Details]

Citations: Scopus - 7Web of Science - 5

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2013Ganga G, Alty JE, Clissold BG, Craig D, Reardon KA, et al., 'Longitudinal study of levodopa in Parkinson's disease: effects of the advanced disease phase', Movement Disorders, 28, (4) pp. 476-481. ISSN 0885-3185 (2013) [Refereed Article]

DOI: 10.1002/mds.25335 [eCite] [Details]

Citations: Scopus - 17Web of Science - 14

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2013Richfield EW, Jones EJS, Alty JE, 'Palliative care for Parkinson's disease: a summary of the evidence and future directions', Palliative Medicine, 27, (9) pp. 805-810. ISSN 0269-2163 (2013) [Contribution to Refereed Journal]

DOI: 10.1177/0269216313495287 [eCite] [Details]

Citations: Scopus - 47Web of Science - 46

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2011Alty JE, Kempster PA, 'A practical guide to the differential diagnosis of tremor', Postgraduate Medical Journal, 87, (1031) pp. 623-9. ISSN 0032-5473 (2011) [Contribution to Refereed Journal]

DOI: 10.1136/pgmj.2009.089623 [eCite] [Details]

Citations: Scopus - 23Web of Science - 14

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2011Wong KK, Alty JE, Goy AG, Raghav S, Reutens DC, et al., 'A randomized, double-blind, placebo-controlled trial of levetiracetam for dyskinesia in Parkinson's disease', Movement Disorders, 26, (8) pp. 1552-1555. ISSN 0885-3185 (2011) [Refereed Article]

DOI: 10.1002/mds.23687 [eCite] [Details]

Citations: Scopus - 23Web of Science - 23

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2009Alty JE, Clissold BJ, McColl CD, Reardon KA, Shiff M, et al., 'Longitudinal study of the levodopa motor response in Parkinson's disease: relationship between cognitive decline and motor function', Movement Disorders, 24, (16) pp. 2337-43. ISSN 0885-3185 (2009) [Refereed Article]

DOI: 10.1002/mds.22800 [eCite] [Details]

Citations: Scopus - 10Web of Science - 7

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2008Alty JE, Ford HL, 'Multi-system complications of hypothermia: a case of recurrent episodic hypothermia with a review of the pathophysiology of hypothermia', Postgraduate Medical Journal, 84, (992) pp. 282-286. ISSN 0032-5473 (2008) [Contribution to Refereed Journal]

DOI: 10.1136/pgmj.2007.066050 [eCite] [Details]

Citations: Scopus - 19Web of Science - 15

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2008Alty JE, Kempster P, Raghav S, 'Cluster-like headache secondary to trigeminal meningioma', Neuroscience, 70, (20) ISSN 0306-4522 (2008) [Contribution to Refereed Journal]

DOI: 10.1212/01.wnl.0000312286.64144.2e [eCite] [Details]

Citations: Scopus - 7Web of Science - 7

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2008Kempster PA, Alty JE, 'John Ruskin's relapsing encephalopathy', Brain, 131, (9) pp. 2520-2525. ISSN 0006-8950 (2008) [Refereed Article]

DOI: 10.1093/brain/awn019 [eCite] [Details]

Citations: Scopus - 6Web of Science - 5

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2007Alty JE, Monaghan TM, Bamford JM, 'A patient with neuro-Behcet's disease is successfully treated with etanercept: Further evidence for the value of TNFα blockade', Clinical Neurology and Neurosurgery, 109, (3) pp. 279-281. ISSN 0303-8467 (2007) [Contribution to Refereed Journal]

DOI: 10.1016/j.clineuro.2006.11.002 [eCite] [Details]

Citations: Scopus - 41Web of Science - 35

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2005Khattar RS, Fox DJ, Alty JE, Arora A, 'Pulmonary artery dissection: An emerging cardiovascular complication in surviving patients with chronic pulmonary hypertension', Heart, 91, (2) pp. 142-145. ISSN 1355-6037 (2005) [Contribution to Refereed Journal]

DOI: 10.1136/hrt.2004.045799 [eCite] [Details]

Citations: Scopus - 63Web of Science - 59

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Book

(3 outputs)
YearCitationAltmetrics
2013Alty J, Hoey E, 'Practical Ultrasound: An Illustrated Guide', CRC Press, United Kingdom, pp. 295. ISBN 9781444168297 (2013) [Authored Other Book]

[eCite] [Details]

2011Hoey E, Alty J, Mankad K, 'Clinical Ultrasound: Case Reviews', Anshan Ltd, United Kingdom, pp. 230. ISBN 9781848290495 (2011) [Authored Other Book]

[eCite] [Details]

2006Alty J, Hoey E, 'Practical Ultrasound: An Illustrated Guide', Hodder Education Publishers, United Kingdom, pp. 256. ISBN 978-1853156038 (2006) [Authored Other Book]

[eCite] [Details]

Chapter in Book

(1 outputs)
YearCitationAltmetrics
2015Alty J, Cosgrove J, 'Neurological and neurosurgical complications of alcohol', ABC in Alcohol, Wiley-Blackwell Publishing Ltd., A McCune (ed), United Kingdom, pp. 64-68. ISBN 978-1-118-54479-2 (2015) [Other Book Chapter]

[eCite] [Details]

Conference Publication

(13 outputs)
YearCitationAltmetrics
2021Abela M, Maxwell H, Alty JE, Lawler K, Bindoff AD, et al., 'Physical activity for dementia risk reduction - not as easy as it sounds', 2021 Australian Dementia Forum, 31 May 2021 - 1 June 2021, online (2021) [Conference Extract]

[eCite] [Details]

Co-authors: Abela M; Maxwell H; Lawler K; Bindoff AD; Farrow M

2021Hill E, Collins J, Bindoff A, King A, Alty J, et al., 'Increased age and higher levels of cognitive reserve are associated with lower serum BDNF levels in healthy older adults', Australian Dementia Forum 2021, 31 May - 1 June, virtual (2021) [Conference Extract]

[eCite] [Details]

Co-authors: Hill E; Collins J; Bindoff A; King A; Summers M; Vickers J

2020Bartlett L, Doherty K, Farrow M, Bindoff A, Kim S, et al., 'Poster - The island study linking ageing and neurodegenerative disease (ISLAND): a longitudinal public health research program targeting dementia risk reduction', 2020 Alzheimer's Association International Conference, 26-30 July 2020, Online (2020) [Conference Extract]

[eCite] [Details]

Co-authors: Bartlett L; Doherty K; Farrow M; Bindoff A; Kim S; Eccleston C; Hill E; King E; Vickers JC

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2020Bartlett L, Doherty K, Farrow M, Bindoff A, Kim S, et al., 'The Island Study Linking Ageing and Neurodegenerative Disease (ISLAND): A longitudinal public health research program targeting dementia risk reduction', Alzheimer's & Dementia ISSN 1552-5260 (2020) [Conference Extract]

DOI: 10.1002/alz.045539 [eCite] [Details]

Co-authors: Bartlett L; Doherty K; Farrow M; Bindoff A; Kim S; Eccleston C; Hill E; King AE; Vickers JC

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2020Zhao Z, Fang H, Williams S, Relton SD, Alty J, et al., 'Time series clustering to examine presence of decrement in Parkinson's finger-tapping bradykinesia', 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 20-24 July 2020, Montreal, QC, Canada, pp. 780-783. ISBN 9781728119908 (2020) [Refereed Conference Paper]

DOI: 10.1109/EMBC44109.2020.9175638 [eCite] [Details]

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2019Alty J, 'Clinical examination in Parkinson's disease', World Congress in Geriatric Medicine - Back to the roots, 30 August - 3 September, Newcastle NSW, Australia (2019) [Plenary Presentation]

[eCite] [Details]

2019Alty J, Bindoff A, Stuart K, Klekociuk S, Vickers J, 'Cognitive reserve in the baseline data of Tasmanian Healthy Brain Project: No effect of age or interaction with gender', The fourth annual NHMRC National Institute for Dementia Research (NNIDR) Australian Dementia Forum, 13-14 June, Hobart, Tasmania (2019) [Conference Extract]

[eCite] [Details]

Co-authors: Bindoff A; Stuart K; Klekociuk S; Vickers J

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2019Xia T, Cosgrove J, Alty J, Jamieson S, Smith J, 'Application of classification for figure copying test in Parkinson's disease diagnosis by using cartesian genetic programming', GECCO '19 Companion, 13-17 July, Prague, Czech Republic, pp. 1855-1863. ISBN 978-1-4503- 6748-6 (2019) [Refereed Conference Paper]

DOI: 10.1145/3319619.3326822 [eCite] [Details]

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2018Muhamed SA, Newby R, Smith SL, Alty J, Jamieson S, et al., 'Objective evaluation of Bradykinesia in Parkinson's disease using evolutionary algorithms', Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018), 19-21 January, Funchal, Madeira, Portugal, pp. 63-69. ISBN 978-989-758-279-0 (2018) [Refereed Conference Paper]

DOI: 10.5220/0006601700630069 [eCite] [Details]

Citations: Scopus - 3

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2017Lones MA, Alty J, Duggan-Carter P, Turner AJ, Jamieson DRS, et al., 'Going through directional changes: evolving human movement classifiers using an event based encoding', GECCO '17: Proceedings of the Genetic and Evolutionary Computation Conference Companion, 15-19 July, Berlin, Germany, pp. 1365-1371. ISBN 978-1-4503-4939-0 (2017) [Refereed Conference Paper]

DOI: 10.1145/3067695.3082490 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

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2016Vallejo M, Cosgrove J, Alty JE, Jamieson S, Smith SL, et al., 'Exploring diagnostic models of Parkinson's disease with multi-objective regression', 2016 IEEE Symposium Series on Computational Intelligence (SSCI), 6-9 December, Athens, Greece (2016) [Refereed Conference Paper]

DOI: 10.1109/SSCI.2016.7849884 [eCite] [Details]

Citations: Scopus - 1

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2015Filby A, Lewis L, Taylor M, Smith SL, Dettmar PW, et al., 'Cost effectiveness analysis of a device to monitor levodopa-induced dyskinesia in Parkinson's patients', ISPOR 18th Annual European Congress, 7-11 November, Milan, Italy, pp. A358. ISSN 1098-3015 (2015) [Conference Extract]

DOI: 10.1016/j.jval.2015.09.682 [eCite] [Details]

Citations: Web of Science - 1

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2015Lones MA, Alty JE, Duggan-Carter P, Turner AJ, Jamieson DRS, et al., 'Classification and characterisation of movement patterns during levodopa therapy for parkinson's disease', 2014 Annual Conference on Genetic and Evolutionary Computation (GECCO'14), 12-16 July, Vancouver, BC, Canada, pp. 1321-1328. ISBN 978-1-4503-2881-4 (2015) [Refereed Conference Paper]

DOI: 10.1145/2598394.2609852 [eCite] [Details]

Citations: Scopus - 7

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Major Creative Work

(1 outputs)
YearCitationAltmetrics
2017Thorpe D, Alty J, Smith SL, Austin J, Hufton S, et al., 'Tremulous Hands', University of York, United Kingdom (2017) [Broadcast]

[eCite] [Details]

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Grants & Funding

Funding Summary

Number of grants

4

Total funding

$2,371,214

Projects

The future in our hands: Screening for preclinical Alzheimer's disease by analysing hand movements (2021 - 2025)$899,782
Description
Global dementia prevalence is rising. Alzheimers disease (AD), the most common cause, has devastating effects on peoples quality of life. AD has a preclinical (pre-AD) period of 1020 years when brain pathology silently progresses before any cognitive symptoms appear. Current tests for pre-AD are invasive, costly and unsuitable for screening at population level. If we cant identify people with pre-AD, we cant offer them early interventions. This hinders our strategies to reduce AD prevalence. We will develop a new scalable test (HandTest) by combining two innovative ideas: hand-movement tests to detect pre-AD >10 years before cognitive symptoms begin; and computer vision so people can self-test online at home. This unique approach builds on the recent discoveries that the posterior cingulate cortex (the first brain region to show abnormalities in pre-AD) is involved in hand-movement control, and that hand-movement patterns change in pre-AD. We will use exquisitely precise computer vision methods to automatically analyse movement data from thousands of participants, who complete the online test by simply opening and closing their hands repeatedly for 5 minutes in front of a standard computer, tablet or smartphone camera. The CI/AI team of experts in hand-movement analysis, pre-AD, computer vision, AD biomarkers and biostatistics has access to 3 well-phenotyped cohorts, >10,000 existing participants and a cutting-edge assay for a blood AD biomarker, ptau181. We will develop a HandTest algorithm to classify hand-movement data for pre-AD risk. In a longitudinal cohort we will determine HandTests precision to prospectively predict 5-year risks of cognitive decline and AD. This is the critical first step for up-scaling HandTest nationwide via memory clinics of the Australian Dementia Network. With worldwide access to computers, tablets and smartphones increasing, HandTest is scalable globally, potentially transforming dementia prevention and management.
Funding
National Health & Medical Research Council ($899,782)
Scheme
Grant-Ideas
Administered By
University of Tasmania
Research Team
Alty JE; Vickers JC; Bai Q; Bindoff AD; Hill E
Period
2021 - 2025
Grant Reference
2004051
A new model of shared care across Geriatric Medicine and General Surgery for older Tasmanians. (2021)$25,000
Description
Older Tasmanians undergoing emergency surgery are at high risk of complications and of subsequently needing rehabilitation or nursing home placement following discharge. We will investigate the need for a novel model of shared Geriatric/General Surgery care for older RHH patients, and measure its effect on return to pre-admission residence and in-hospital complications.
Funding
Royal Hobart Hospital Research Foundation ($25,000)
Scheme
Grant-Project
Administered By
University of Tasmania
Research Team
Evans T; Ferrah N; Turner RC; Jose M; Britcliffe A; Alty JE; Vickers JC; Campbell JA
Year
2021
Blood-based biomarkers for neurodegeneration and dementia (2020 - 2022)$449,386
Description
This project will characterise a blood biomarker of neurodegeneration for prognostic and diagnostic value to predict cognitive decline and dementia.
Funding
Royal Hobart Hospital Research Foundation ($449,386)
Scheme
Grant-Major Project
Administered By
University of Tasmania
Research Team
Collins J; Vickers JC; King AE; Alty JE; Cooper PD
Period
2020 - 2022
HDAC6 inhibition to rescue axon degeneration in ALS (2019 - 2022)$997,046
Description
We will test an HDAC6 inhibitor in models of ALS. We will investigate the HDA6 inhibitor activity of novel compounds
Funding
FightMND ($997,046)
Scheme
Grant - Drug Development Grant
Administered By
University of Tasmania
Research Team
King AE; Cook AL; Guven N; Van Den Bosch L; Dickson TC; Blizzard C; Vickers JC; Smith JA; Alty JE; Leung JY; Perry SE
Period
2019 - 2022

Research Supervision

Current

5

Current

DegreeTitleCommenced
PhDIdentifying Pre-cognitive Biomarkers of the Earliest Stages of Dementia using Artificial Intelligence Analyses of Eye, Face and Limb Movements2019
PhDA Clinical Support Tool to Aid Delivering a Diagnosis of Dementia Well. A mixed methods study2020
PhDPost-diagnostic Support in Australian Memory Clinics2020
PhDREM Sleep Behaviour Disorder: Prevalence and cognitive characteristics2020
PhDApplying Artificial Intelligence to Identify New Tremor Biomarkers of Dementia Risk2021