Profiles

Jessica Collins

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Jessica Collins

Research Fellow

Medical Science 1, Level 4 , Hobart CBD Campuses

View more on Dr Jessica Collins in WARP

Fields of Research

  • Neurology and neuromuscular diseases (320905)
  • Cellular nervous system (320902)
  • Central nervous system (320903)
  • Neurosciences (320999)
  • Cognitive neuroscience (520203)
  • Behavioural neuroscience (520202)
  • Geriatrics and gerontology (320210)
  • Artificial intelligence (460299)
  • Peripheral nervous system (320906)
  • Virtual and mixed reality (460708)
  • Preventative health care (420605)
  • Digital health (420302)
  • Analytical biochemistry (310101)
  • Behavioural epidemiology (420201)
  • Cell development, proliferation and death (310102)
  • Proteomics and intermolecular interactions (excl. medical proteomics) (310109)
  • Primary health care (420319)
  • Intensive care (320212)

Research Objectives

  • Clinical health (200199)
  • Health related to ageing (200502)
  • Diagnosis of human diseases and conditions (200101)
  • Determinants of health (200201)
  • Preventive medicine (200412)
  • Prevention of human diseases and conditions (200104)
  • Behaviour and health (200401)
  • Mental health (200409)
  • Treatment of human diseases and conditions (200105)
  • Expanding knowledge in the information and computing sciences (280115)
  • Injury prevention and control (200408)
  • Efficacy of medications (200102)

Publications

Total publications

13

Journal Article

(11 outputs)
YearCitationAltmetrics
2021Bucher EA, Collins JM, King AE, Vickers JC, Kirkcaldie MTK, 'Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net', Brain structure & Function, 226, (7) pp. 2041-2055. ISSN 1863-2653 (2021) [Refereed Article]

DOI: 10.1007/s00429-021-02327-3 [eCite] [Details]

Citations: Scopus - 1Web of Science - 1

Co-authors: Bucher EA; King AE; Vickers JC; Kirkcaldie MTK

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2021Collins JM, Hill E, Bindoff A, King AE, Alty J, et al., 'Association Between Components of Cognitive Reserve and Serum BDNF in Healthy Older Adults', Frontiers in Aging Neuroscience, 13 pp. 1-9. ISSN 1663-4365 (2021) [Refereed Article]

DOI: 10.3389/fnagi.2021.725914 [eCite] [Details]

Co-authors: Hill E; Bindoff A; King AE; Alty J; Summers MJ; Vickers JC

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2021Tang AD, Bennett W, Bindoff AD, Bolland S, Collins J, et al., 'Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex', Brain Stimulation, 14 pp. 1498-1507. ISSN 1935-861X (2021) [Refereed Article]

DOI: 10.1016/j.brs.2021.10.001 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Bennett W; Bindoff AD; Langley RC; Garry MI; Summers JJ; Hinder MR; Canty AJ

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2020Collins JM, Woodhouse A, Bye N, Vickers JC, King AE, et al., 'Pathological links between traumatic brain injury and dementia: Australian pre-clinical research', Journal of Neurotrauma, 37, (5) pp. 782-791. ISSN 0897-7151 (2020) [Refereed Article]

DOI: 10.1089/neu.2019.6906 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: Woodhouse A; Bye N; Vickers JC; King AE; Ziebell JM

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2019Collins JM, King AE, Woodhouse A, Kirkcaldie MTK, Vickers JC, 'Age moderates the effects of traumatic brain injury on beta-amyloid plaque load in APP/PS1 mice', Journal of Neurotrauma, 36, (11) pp. 1876-1889. ISSN 0897-7151 (2019) [Refereed Article]

DOI: 10.1089/neu.2018.5982 [eCite] [Details]

Citations: Scopus - 9Web of Science - 11

Co-authors: King AE; Woodhouse A; Kirkcaldie MTK; Vickers JC

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2019Stuart KE, King AE, King NE, Collins JM, Vickers JC, et al., 'Late-life environmental enrichment preserves short-term memory and may attenuate microglia in male APP/PS1 mice', Neuroscience, 408 pp. 282-292. ISSN 0306-4522 (2019) [Refereed Article]

DOI: 10.1016/j.neuroscience.2019.04.015 [eCite] [Details]

Citations: Scopus - 9Web of Science - 11

Co-authors: Stuart KE; King AE; King NE; Vickers JC; Ziebell JM

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2018O'Mara AR, Collins JM, King AE, Vickers JC, Kirkcaldie MTK, 'Accurate and unbiased quantitation of Amyloid-β fluorescence images using ImageSURF', Current Alzheimer Research, 16, (2) pp. 102-108. ISSN 1567-2050 (2018) [Refereed Article]

DOI: 10.2174/1567205016666181212152622 [eCite] [Details]

Citations: Scopus - 4Web of Science - 4

Co-authors: O'Mara AR; King AE; Vickers JC; Kirkcaldie MTK

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2018Tang AD, Bennett W, Hadrill C, Collins J, Fulopova B, et al., 'Low intensity repetitive transcranial magnetic stimulation modulates skilled motor learning in adult mice', Scientific Reports, 8 Article 4016. ISSN 2045-2322 (2018) [Refereed Article]

DOI: 10.1038/s41598-018-22385-8 [eCite] [Details]

Citations: Scopus - 18Web of Science - 16

Co-authors: Bennett W; Hadrill C; Fulopova B; Wills K; Bindoff A; Puri R; Garry MI; Hinder MR; Summers JJ; Canty AJ

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2018Woodhouse A, Fernandez-Martos CM, Atkinson RAK, Hanson KA, Collins JM, et al., 'Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer's disease mice', BMC Anesthesiology, 18, (1) Article 47. ISSN 1471-2253 (2018) [Refereed Article]

DOI: 10.1186/s12871-018-0509-5 [eCite] [Details]

Citations: Scopus - 3Web of Science - 3

Co-authors: Woodhouse A; Fernandez-Martos CM; Atkinson RAK; Hanson KA; O'Mara AR; Terblanche N; Skinner MW; Vickers JC; King AE

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2016Kirkcaldie MTK, Collins JM, 'The axon as a physical structure in health and acute trauma', Journal of Chemical Neuroanatomy, 76, (Part A) pp. 9-18. ISSN 0891-0618 (2016) [Refereed Article]

DOI: 10.1016/j.jchemneu.2016.05.006 [eCite] [Details]

Citations: Scopus - 11Web of Science - 11

Co-authors: Kirkcaldie MTK

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2015Collins JM, King AE, Woodhouse A, Kirkcaldie MTK, Vickers JC, 'The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease', Experimental Neurology, 267 pp. 219-29. ISSN 0014-4886 (2015) [Refereed Article]

DOI: 10.1016/j.expneurol.2015.02.034 [eCite] [Details]

Citations: Scopus - 37Web of Science - 38

Co-authors: King AE; Woodhouse A; Kirkcaldie MTK; Vickers JC

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Conference Publication

(2 outputs)
YearCitationAltmetrics
2021Hill E, Collins J, Bindoff A, King A, Alty J, et al., 'Increased age and higher levels of cognitive reserve are associated with lower serum BDNF levels in healthy older adults', Australian Dementia Forum 2021, 31 May - 1 June, virtual (2021) [Conference Extract]

[eCite] [Details]

Co-authors: Hill E; Bindoff A; King A; Alty J; Summers M; Vickers J

2014Collins J, King A, Woodhouse A, Kirkcaldie M, Vickers J, 'The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease', Society for Neuroscience Meeting 2014, November 2014, Washington DC (2014) [Conference Extract]

[eCite] [Details]

Co-authors: King A; Woodhouse A; Kirkcaldie M; Vickers J

Grants & Funding

Funding Summary

Number of grants

4

Total funding

$677,218

Projects

Developing new tools to diagnose and monitor MND (2022)$98,626
Description
This project aims to develop two new ultrasensitive single molecule array blood biomarker assays for the detection of the neurofilament proteins alpha-internexin and peripherin, which are specific to the central and peripheral nervous systems. We will then test the ability of these blood biomarker assays to detect central versus peripheral nervous system degeneration in mouse models of motor neuron disease and human motor neuron disease cases.
Funding
Motor Neurone Disease Research Australia ($98,626)
Scheme
Grant - Innovator
Administered By
University of Tasmania
Research Team
Collins J; King AE; Rogers ML
Year
2022
Detecting microvascular injury after stroke using a blood test (2022)$9,820
Description
Pericytes, cells controlling blood flow in the brain, are injured post-stroke. This may increase brain injury and worsen neurological disability. This project will develop a blood test for detecting pericyte injury. This test may be useful for diagnosing blood flow impairments or predicting brain injury and neurological disability post-stroke.
Funding
Royal Hobart Hospital Research Foundation ($9,820)
Scheme
Grant-Incubator
Administered By
University of Tasmania
Research Team
Morris GP; Sutherland BA; Howells DW; King AE; Castley HJ; Courtney J; Collins J
Year
2022
Developing biosensors for high throughput screening to detect those at risk of dementia (2021)$119,386
Description
Recently, proteins have been identified in the blood that can act as indicators that a person is at risk of developing dementia or neurodegenerative disease. This opens a window of opportunity for early intervention and preventative strategies. At present these proteins need to be measured using equipment not available to health professionals and the current methods use antibodies as biosensors. Antibodies are unstable, difficult to produce and expensive, and therefore not suited for wide-spread distribution of detection devices. Aptamers are single-stranded oligonucleotide (DNA or RNA) molecules, which can bind to target molecules with high affinity and specificity. They are ideal for use as biosensors in point-of-care devices as they are stable at room temperature and are cheap to produce. Our goal is to develop biomarker detection devices that are suitable for population-based screening. This project will develop aptamers to key biomarker indicators of brain health such as neurofilament light chain and tau.
Funding
Perpetual Trustees ($119,386)
Scheme
Grant-Trust Fund
Administered By
University of Tasmania
Research Team
King AE; Breadmore MC; Gell DA; Collins J; Shigdar S
Year
2021
Blood-based biomarkers for neurodegeneration and dementia (2020 - 2022)$449,386
Description
This project will characterise a blood biomarker of neurodegeneration for prognostic and diagnostic value to predict cognitive decline and dementia.
Funding
Royal Hobart Hospital Research Foundation ($449,386)
Scheme
Grant-Major Project
Administered By
University of Tasmania
Research Team
Collins J; Vickers JC; King AE; Alty JE; Cooper PD
Period
2020 - 2022

Research Supervision

Current

4

Current

DegreeTitleCommenced
PhDThe Role of Wallerian Degeneration and Axon Loss in Dementia2019
PhDExcitatory-Inhibitory Relationships in Cerebral Cortex Affected by the Pathology of Alzheimer's Disease2019
PhDUnderstanding Axon Pathology in Ageing and Dementia2020
PhDExpanding Our Understanding of Neurofilament Proteins as Biomarkers of Neurodegeneration2022