Profiles
Jessica Collins
UTAS Home Dr Jessica Collins
Jessica Collins
Research Fellow
Medical Science 1, Level 4 , Hobart CBD Campuses
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Fields of Research
- Neurology and neuromuscular diseases (320905)
- Cellular nervous system (320902)
- Central nervous system (320903)
- Neurosciences (320999)
- Geriatrics and gerontology (320210)
- Cognitive neuroscience (520203)
- Behavioural neuroscience (520202)
- Peripheral nervous system (320906)
- Artificial intelligence (460299)
- Virtual and mixed reality (460708)
- Cardiology (incl. cardiovascular diseases) (320101)
- Exercise physiology (420702)
- Preventative health care (420605)
- Speech recognition (460212)
- Applications in health (460102)
- Digital health (420302)
- Analytical biochemistry (310101)
- Behavioural epidemiology (420201)
- Proteomics and intermolecular interactions (excl. medical proteomics) (310109)
- Cell development, proliferation and death (310102)
- Primary health care (420319)
- Intensive care (320212)
Research Objectives
- Clinical health (200199)
- Diagnosis of human diseases and conditions (200101)
- Health related to ageing (200502)
- Determinants of health (200201)
- Prevention of human diseases and conditions (200104)
- Preventive medicine (200412)
- Treatment of human diseases and conditions (200105)
- Behaviour and health (200401)
- Mental health (200409)
- Expanding knowledge in the information and computing sciences (280115)
- Efficacy of medications (200102)
- Exercise (130601)
- Artificial intelligence (220403)
- Injury prevention and control (200408)
Publications
Total publications
16
Journal Article
(13 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2022 | Alty JE, Bai Q, Li R, Lawler K, St George RJ, et al., 'The TAS Test project: a prospective longitudinal validation of new online motor-cognitive tests to detect preclinical Alzheimer's disease and estimate 5-year risks of cognitive decline and dementia', BMC Neurology, 22 Article 266. ISSN 1471-2377 (2022) [Refereed Article] DOI: 10.1186/s12883-022-02772-5 [eCite] [Details] Citations: Scopus - 2Web of Science - 2 Co-authors: Alty JE; Bai Q; Li R; Lawler K; St George RJ; Hill E; Bindoff A; Garg S; Wang X; Huang G; Zhang K; Rudd KD; Bartlett L; Goldberg LR; Hinder MR; King AE; Vickers JC | |
| 2022 | Alty JE, Bindoff A, Stuart K, Hill E, Collins J, et al., 'Sex-specific protective effects of cognitive reserve on age-related cognitive decline: A 5-Year prospective cohort study', Neurology ISSN 0028-3878 (2022) [Refereed Article] DOI: 10.1212/WNL.0000000000201369 [eCite] [Details] Co-authors: Alty JE; Bindoff A; Stuart K; Hill E; King A; Vickers J | |
| 2021 | Bucher EA, Collins JM, King AE, Vickers JC, Kirkcaldie MTK, 'Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net', Brain structure & Function, 226, (7) pp. 2041-2055. ISSN 1863-2653 (2021) [Refereed Article] DOI: 10.1007/s00429-021-02327-3 [eCite] [Details] Citations: Scopus - 5Web of Science - 6 Co-authors: Bucher EA; King AE; Vickers JC; Kirkcaldie MTK | |
| 2021 | Collins JM, Hill E, Bindoff A, King AE, Alty J, et al., 'Association Between Components of Cognitive Reserve and Serum BDNF in Healthy Older Adults', Frontiers in Aging Neuroscience, 13 pp. 1-9. ISSN 1663-4365 (2021) [Refereed Article] DOI: 10.3389/fnagi.2021.725914 [eCite] [Details] Citations: Scopus - 6Web of Science - 6 Co-authors: Hill E; Bindoff A; King AE; Alty J; Summers MJ; Vickers JC | |
| 2021 | Tang AD, Bennett W, Bindoff AD, Bolland S, Collins J, et al., 'Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex', Brain Stimulation, 14 pp. 1498-1507. ISSN 1935-861X (2021) [Refereed Article] DOI: 10.1016/j.brs.2021.10.001 [eCite] [Details] Citations: Scopus - 6Web of Science - 6 Co-authors: Bennett W; Bindoff AD; Langley RC; Garry MI; Summers JJ; Hinder MR; Canty AJ | |
| 2020 | Collins JM, Woodhouse A, Bye N, Vickers JC, King AE, et al., 'Pathological links between traumatic brain injury and dementia: Australian pre-clinical research', Journal of Neurotrauma, 37, (5) pp. 782-791. ISSN 0897-7151 (2020) [Refereed Article] DOI: 10.1089/neu.2019.6906 [eCite] [Details] Citations: Scopus - 4Web of Science - 4 Co-authors: Woodhouse A; Bye N; Vickers JC; King AE; Ziebell JM | |
| 2019 | Collins JM, King AE, Woodhouse A, Kirkcaldie MTK, Vickers JC, 'Age moderates the effects of traumatic brain injury on beta-amyloid plaque load in APP/PS1 mice', Journal of Neurotrauma, 36, (11) pp. 1876-1889. ISSN 0897-7151 (2019) [Refereed Article] DOI: 10.1089/neu.2018.5982 [eCite] [Details] Citations: Scopus - 12Web of Science - 12 Co-authors: King AE; Woodhouse A; Kirkcaldie MTK; Vickers JC | |
| 2019 | Stuart KE, King AE, King NE, Collins JM, Vickers JC, et al., 'Late-life environmental enrichment preserves short-term memory and may attenuate microglia in male APP/PS1 mice', Neuroscience, 408 pp. 282-292. ISSN 0306-4522 (2019) [Refereed Article] DOI: 10.1016/j.neuroscience.2019.04.015 [eCite] [Details] Citations: Scopus - 14Web of Science - 15 Co-authors: Stuart KE; King AE; King NE; Vickers JC; Ziebell JM | |
| 2018 | O'Mara AR, Collins JM, King AE, Vickers JC, Kirkcaldie MTK, 'Accurate and unbiased quantitation of Amyloid-β fluorescence images using ImageSURF', Current Alzheimer Research, 16, (2) pp. 102-108. ISSN 1567-2050 (2018) [Refereed Article] DOI: 10.2174/1567205016666181212152622 [eCite] [Details] Citations: Scopus - 7Web of Science - 6 Co-authors: O'Mara AR; King AE; Vickers JC; Kirkcaldie MTK | |
| 2018 | Tang AD, Bennett W, Hadrill C, Collins J, Fulopova B, et al., 'Low intensity repetitive transcranial magnetic stimulation modulates skilled motor learning in adult mice', Scientific Reports, 8 Article 4016. ISSN 2045-2322 (2018) [Refereed Article] DOI: 10.1038/s41598-018-22385-8 [eCite] [Details] Citations: Scopus - 20Web of Science - 18 Co-authors: Bennett W; Hadrill C; Fulopova B; Wills K; Bindoff A; Puri R; Garry MI; Hinder MR; Summers JJ; Canty AJ | |
| 2018 | Woodhouse A, Fernandez-Martos CM, Atkinson RAK, Hanson KA, Collins JM, et al., 'Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer's disease mice', BMC Anesthesiology, 18, (1) Article 47. ISSN 1471-2253 (2018) [Refereed Article] DOI: 10.1186/s12871-018-0509-5 [eCite] [Details] Citations: Scopus - 6Web of Science - 6 Co-authors: Woodhouse A; Fernandez-Martos CM; Atkinson RAK; Hanson KA; O'Mara AR; Terblanche N; Skinner MW; Vickers JC; King AE | |
| 2016 | Kirkcaldie MTK, Collins JM, 'The axon as a physical structure in health and acute trauma', Journal of Chemical Neuroanatomy, 76, (Part A) pp. 9-18. ISSN 0891-0618 (2016) [Refereed Article] DOI: 10.1016/j.jchemneu.2016.05.006 [eCite] [Details] Citations: Scopus - 14Web of Science - 11 Co-authors: Kirkcaldie MTK | |
| 2015 | Collins JM, King AE, Woodhouse A, Kirkcaldie MTK, Vickers JC, 'The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease', Experimental Neurology, 267 pp. 219-29. ISSN 0014-4886 (2015) [Refereed Article] DOI: 10.1016/j.expneurol.2015.02.034 [eCite] [Details] Citations: Scopus - 39Web of Science - 39 Co-authors: King AE; Woodhouse A; Kirkcaldie MTK; Vickers JC |
Conference Publication
(3 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2022 | Alty J, Salmon K, Lawler K, McDonald S, Stuart K, et al., 'The ISLAND clinic: first year outcomes of a new state-wide one-stop' cognitive clinic in Tasmania', ADRF - Australian Dementia Research Forum, 30-31 May 2022, Online (2022) [Conference Extract] Co-authors: Alty J; Salmon K; Lawler K; McDonald S; Stuart K; Cleary A; Beaumont M; Radfar N; Ma WJ; King A; Vickers J | |
| 2021 | Hill E, Collins J, Bindoff A, King A, Alty J, et al., 'Increased age and higher levels of cognitive reserve are associated with lower serum BDNF levels in healthy older adults', Australian Dementia Forum 2021, 31 May - 1 June, virtual (2021) [Conference Extract] Co-authors: Hill E; Bindoff A; King A; Alty J; Summers M; Vickers J | |
| 2014 | Collins J, King A, Woodhouse A, Kirkcaldie M, Vickers J, 'The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease', Society for Neuroscience Meeting 2014, November 2014, Washington DC (2014) [Conference Extract] Co-authors: King A; Woodhouse A; Kirkcaldie M; Vickers J |
Grants & Funding
Funding Summary
Number of grants
7
Total funding
$812,184
Projects
The Yulgilbar Foundation Professor Bob Williamson PhD Top-up Scholarship (2023 - 2025)$10,000
- Description
- Top up scholarship and travel award for Laura de Paoli to support PhD students and to travel to a conference to present work and/or potentially set up a collaboration.
- Funding
- The Yulgilbar Foundation ($10,000)
- Scheme
- Contract Research
- Administered By
- University of Tasmania
- Research Team
- King AE; Collins J; De Paoli LF
- Period
- 2023 - 2025
Exploring clinic manifestations of late-onset Essential Tremor: a pre-cognitive biomarker of dementia? (2023)$24,966
- Description
- Shaking up our approach to detecting dementia: using tremor analysis to develop a new pre-cognitive test of dementia risk
- Funding
- Royal Hobart Hospital Research Foundation ($24,966)
- Scheme
- Grant-Project
- Administered By
- University of Tasmania
- Research Team
- Wang X; Alty JE; St George RJ; Lawler K; Hewer S; Collins J; Rudd KD; Sutherland A
- Year
- 2023
Refinement of p75 ECD measurement as a biomarker for clinical trials for MND (2023)$100,000
- Description
- Our grant aims to improve the measurement of a strong candidate MND biomarker, p75ECD in urine and blood. By developing a more sensitive SIngle MOlecule Array assay we will improve and expand use of urinary p75ECD for clinical trials and improve quantification in the blood. This will pave the way for p75ECD to be used in more widely in clinical trials to determine effective treatments.
- Funding
- Motor Neurone Disease Research Australia ($100,000)
- Scheme
- Grant - Innovator
- Administered By
- Flinders University
- Research Team
- Rogers ML; King AE; Collins J; Schultz D; Benyamin B
- Year
- 2023
Developing new tools to diagnose and monitor MND (2022)$98,626
- Description
- This project aims to develop two new ultrasensitive single molecule array blood biomarker assays for the detection of the neurofilament proteins alpha-internexin and peripherin, which are specific to the central and peripheral nervous systems. We will then test the ability of these blood biomarker assays to detect central versus peripheral nervous system degeneration in mouse models of motor neuron disease and human motor neuron disease cases.
- Funding
- Motor Neurone Disease Research Australia ($98,626)
- Scheme
- Grant - Innovator
- Administered By
- University of Tasmania
- Research Team
- Collins J; King AE; Rogers ML
- Year
- 2022
Detecting microvascular injury after stroke using a blood test (2022)$9,820
- Description
- Pericytes, cells controlling blood flow in the brain, are injured post-stroke. This may increase brain injury and worsen neurological disability. This project will develop a blood test for detecting pericyte injury. This test may be useful for diagnosing blood flow impairments or predicting brain injury and neurological disability post-stroke.
- Funding
- Royal Hobart Hospital Research Foundation ($9,820)
- Scheme
- Grant-Incubator
- Administered By
- University of Tasmania
- Research Team
- Morris GP; Sutherland BA; Howells DW; King AE; Castley HJ; Courtney J; Collins J
- Year
- 2022
Developing biosensors for high throughput screening to detect those at risk of dementia (2021)$119,386
- Description
- Recently, proteins have been identified in the blood that can act as indicators that a person is at risk of developing dementia or neurodegenerative disease. This opens a window of opportunity for early intervention and preventative strategies. At present these proteins need to be measured using equipment not available to health professionals and the current methods use antibodies as biosensors. Antibodies are unstable, difficult to produce and expensive, and therefore not suited for wide-spread distribution of detection devices. Aptamers are single-stranded oligonucleotide (DNA or RNA) molecules, which can bind to target molecules with high affinity and specificity. They are ideal for use as biosensors in point-of-care devices as they are stable at room temperature and are cheap to produce. Our goal is to develop biomarker detection devices that are suitable for population-based screening. This project will develop aptamers to key biomarker indicators of brain health such as neurofilament light chain and tau.
- Funding
- Perpetual Trustees ($119,386)
- Scheme
- Grant-Trust Fund
- Administered By
- University of Tasmania
- Research Team
- King AE; Breadmore MC; Gell DA; Collins J; Shigdar S
- Year
- 2021
Blood-based biomarkers for neurodegeneration dementia (2020 - 2022)$449,386
- Description
- This project will characterise a blood biomarker of neurodegeneration for prognostic and diagnostic value to predict cognitive decline and dementia.
- Funding
- Royal Hobart Hospital Research Foundation ($449,386)
- Scheme
- Grant-Major Project
- Administered By
- University of Tasmania
- Research Team
- Collins J; Vickers JC; King AE; Alty JE; Cooper PD
- Period
- 2020 - 2022
Research Supervision
Current
4
Current
| Degree | Title | Commenced |
|---|---|---|
| PhD | The Role of Wallerian Degeneration and Axon Loss in Dementia | 2019 |
| PhD | Parvalbumin Interneurons and Perineuronal Nets in Ageing and Neurodegeneration | 2019 |
| PhD | Understanding Axon Pathology in Ageing and Dementia | 2020 |
| PhD | Expanding Our Understanding of Neurofilament Proteins as Biomarkers of Neurodegeneration | 2022 |