18 July 2022
About the research project
Preeclampsia is a complex pregnancy specific disorder characterized by new onset hypertension and proteinuria affecting 3 - 8% of pregnant women. Preeclampsia is known to be a heritable disease and while there has been success in the identification of some genes, these identified variants do not explain all the expected genetic variation. This project aims to identify novel rare genetic variation in families with a history of preeclampsia that may explain some of this “missing heritability”. You will use advanced bioinformatic workflows for whole-genome-sequencing to identify novel rare variants that segregate with preeclampsia in these families. Independent cohorts and publicly available databases will then be used to further screen these variants. This information will then be integrated with transcriptomic and epigenomic datasets to prioritise potential functional or regulatory variants associated with preeclampsia. This will provide new information on the molecular aetiology of preeclampsia and in the future may help identify those women most at risk of developing this disease.
Primary SupervisorMeet Prof Eric Moses
Applicants will be considered for a Research Training Program (RTP) scholarship or Tasmania Graduate Research Scholarship (TGRS) which, if successful, provides:
- a living allowance stipend of $28,854 per annum (2022 rate, indexed annually) for 3.5 years
- a relocation allowance of up to $2,000
- a tuition fees offset covering the cost of tuition fees for up to four years (domestic applicants only)
If successful, international applicants will receive a University of Tasmania Fees Offset for up to four years.
As part of the application process you may indicate if you do not wish to be considered for scholarship funding.
Applicants should review the Higher Degree by Research minimum entry requirements.
The project is competitively assessed and awarded. Selection is based on academic merit and suitability to the project as determined by the College.
There is a three-step application process:
- Select your project, and check you meet the eligibility and selection criteria;
- Contact the Primary Supervisor, Prof Eric Moses to discuss your suitability and the project's requirements; and
- Submit an application by the closing date listed above.
- Copy and paste the title of the project from this advertisement into your application. If you don’t correctly do this your application may be rejected.
- As part of your application, you will be required to submit a covering letter, a CV including 2 x referees and your project research proposal.
Following the application closing date applications will be assessed within the College. Applicants should expect to receive notification of the outcome by email by the advertised outcome date.