25 September 2023
Domestic / International
About the research project
Bone marrow failure syndromes (BMFS) are a collection of heterogeneous disorders characterized by decreased production of one or more major hematopoietic lineages, which may be either inherited or acquired. BMFS is caused by inefficient haematopoiesis in the bone marrow (BM) stem cells, which means the number of red blood cells, white blood cells and platelets are insufficient to meet physiological needs. Approximately 160 Australians, the majority of whom are children or adolescents, are diagnosed with a BMFS each year. More than 50 percent of these patients will die from their disease. The outcome of these patients has greatly improved in recent years but is still poor for patients who lack a sibling donor and who failed or relapsed after immunosuppressive therapy.
Haematopoiesis involves the lineage-specification of blood cells, and is driven by context and cell-type specific gene expression. Variation in the expression of these genes that govern the differentiation and development of cell lineages directly alters production and activation of different blood cells. When regulation of this process goes awry, disease such as BMFS results. Since nearly all clinically measured hematopoietic traits exhibit extensive variation and are highly heritable, there is tremendous potential and excitement for the future of genetics and applications to understand human haematopoiesis.
We aim to understand the contribution of genetic variation in driving haematopoietic cell development, through dissecting the genetic drivers for haematopoiesis at a single cell resolution. This project will involve a mix of bioinformatics and wet lab work, initially working on the analysis of allelic effects on transcription changes from a cohort of niche BM samples that have already been collected. To functionally confirm our in silico findings we will design and perform CRISPR screens to model the effect of genetic variants on haematopoietic development and to understand the consequences.
Primary SupervisorMeet Dr Kirsten Fairfax
Applicants will be considered for a Research Training Program (RTP) scholarship or Tasmania Graduate Research Scholarship (TGRS) which, if successful, provides:
- a living allowance stipend of $31,500 per annum (2023 rate, indexed annually) for 3.5 years
- a relocation allowance of up to $2,000
- a tuition fees offset covering the cost of tuition fees for up to four years (domestic applicants only)
If successful, international applicants will receive a University of Tasmania Fees Offset for up to four years.
As part of the application process you may indicate if you do not wish to be considered for scholarship funding.
Other funding opportunities and fees
For further information regarding other scholarships on offer, and the various fees of undertaking a research degree, please visit our Scholarships and fees on research degrees page.
Applicants should review the Higher Degree by Research minimum entry requirements.
Ensure your eligibility for the scholarship round by referring to our Key Dates.
Additional eligibility criteria specific to this project/scholarship:
- Applicants must be able to undertake the project on-campus
The project is competitively assessed and awarded. Selection is based on academic merit and suitability to the project as determined by the College.
Additional desirable selection criteria specific to this project:
- Previous experience with cell culture and culturing primary cells
- Select your project, and check that you meet the eligibility and selection criteria, including citizenship;
- Contact Dr Kirsten Fairfax to discuss your suitability and the project's requirements; and
- In your application:
- Copy and paste the title of the project from this advertisement into your application. If you don’t correctly do this your application may be rejected.
- Submit a signed supervisory support form, a CV including contact details of 2 referees and your project research proposal.
- Apply prior to 25 September 2023.
Following the closing date applications will be assessed within the College. Applicants should expect to receive notification of the outcome by email by the advertised outcome date.