Host-Pathogen Interactions - The Roddam Group

We are interested in understanding the molecular interactions that occur between bacterial pathogens and their human host.

Our research focusses on studying bacterial pathogens present in the lungs of people with Cystic Fibrosis (CF) and the host response to these infections. Our research goal is to inform antimicrobial treatment strategies and develop new therapeutics to prevent infections.

Expertise

  • Mammalian cell infections
  • Gene and protein expression analysis (microbial and human host)
  • Production of recombinant proteins
  • Molecular Biology
  • Microbial identification and genetics
  • Peripheral Blood Immune Cell Profiling

Projects

Improving treatment of chronic lung infections in people with cystic fibrosis

Cystic fibrosis (CF) is an inherited life-shortening condition that results in the build-up of thick

and sticky mucus lining the airways that is particularly prone to chronic infection by Pseudomonas aeruginosa. We have developed, and are currently testing, an anti-Pseudomonal therapy.

Characterisation of Pandoraea, an emerging lung pathogen in people with cystic fibrosis

Pandoraea, an emerging bacterial lung pathogen, is highly antibiotic resistant and has recently been isolated from several Tasmanian CF patient. We are studying these new isolates to advance our understanding of this pathogen in order to improve treatment strategies.

Alterations in the peripheral blood innate immune cell profile in cystic fibrosis

The aim of this study is to identify new therapeutic targets and potential biomarkers for patient management by characterizing the peripheral blood innate immune cell phenotype in people with CF compared with healthy controls and disease carriers.

Group Leader(s)

Contact

Email: lfroddam@utas.edu.au

Group members

Dr Joanne Pagnon

Ms Simone Page

Ms Hannah Nugent

Ms Heshadi Primrose Mandalawatta