Profiles
Adele Vincent
Adele Vincent
NHMRC Research Fellow
Menzies Institute for Medical Research
Room 439-09 , Medical Science 2
Dr Adele Vincent is an NHMRC Research Fellow at the Menzies Institute for Medical Research. She is interested in the role of immune cells in the cause of Alzheimer's disease.
Biography
Dr Vincent has been a neuroscience researcher with a long-standing interest in the involvement of glial cells and immune cells in neurological diseases.
Adele is currently working in the field of Alzheimer's disease, investigating how the brain's immune cells, microglia, could be causative in Alzheimer's disease. This work is being performed on a part-time basis in the Laboratory of Molecular Neurobiology, Menzies Institute of Medical Research, while raising a family.
Previously, Dr Vincent worked for two years as a Postdoctoral Researcher at the University of British Columbia, Vancouver, Canada. There she investigated the role of a plasticity-related gene, SPARC/osteonectin in neural development and regeneration following stroke. She discovered that SPARC was expressed exclusively in glial cells and microglia, not in neurons.
Adele's PhD was obtained at the University of Tasmania in 2005, studying the molecular and cellular biology of olfactory glial cells. A major finding that stemmed from her PhD work involved a new understanding of olfactory glial cells as potential immune protectors of the brain.
Prior to PhD studies, Adele travelled extensively, worked for a year as a research assistant at Griffith University, Queensland, and did a BSc(Hons) at the University of Tasmania.
Career summary
Qualifications
- PhD, University of Tasmania, Australia, 2005. The molecular and cellular characterisation of olfactory ensheathing cells
- BSc (1st Class Hons), University of Tasmania, Australia, 1997. Metallothionein expression in mouse brown adipose tissue
Teaching
Biochemistry, neuroscience, anatomy & physiology
Teaching expertise
- Biochemistry, 3rd year, guest lecturer for 5 lectures (4 years duration)
- Neuroscience, 1st year, guest lecturer and demonstrator (1 year duration)
- Human anatomy & physiology demonstrator, 1st year (1 year duration)
View more on Dr Adele Vincent in WARP
Expertise
- Alzheimer's disease
- Glial cell biology
- Innate immune system
- Neural development
- Olfactory system
Research Themes
Adele's research aligns to the University's research theme of Better Health. Her interest lies in understanding how neurological diseases could be caused by the non-neuronal cells of the nervous system - the glial cells (mainly astrocytes) and the immune cells (microglia). Her fascination in glial cell biology stems from over a decade of working with various populations of these highly adaptable cells, long before they were generally considered to be important to neurological function. However, in the past few years, an explosion of new research has begun to reveal the vital importance of glial cells and microglia to every aspect of brain function, from development through to healthy aging.
Adele is currently investigating how microglia could cause Alzheimer's disease. She is studying the interactions between microglia, neurons, and the peptide, Abeta, which is a pathological marker of Alzheimer's disease.
Collaboration
Adele established a collaboration during her PhD to perform microarrays at the Queensland Institute of Medical Research in Brisbane.
Current projects
- The involvement of amyloid precursor protein in actin-related functions of microglia.
- Is beta-amyloid toxic to healthy microglia?
- The role of microglia in synaptogenesis.
Fields of Research
- Cellular nervous system (320902)
- Central nervous system (320903)
- Neurosciences (320999)
- Neurology and neuromuscular diseases (320905)
- Cell neurochemistry (310104)
- Animal physiology - cell (310909)
- Sensory systems (320907)
- Cellular interactions (incl. adhesion, matrix, cell wall) (310105)
- Cell development, proliferation and death (310102)
Research Objectives
- Clinical health (200199)
- Expanding knowledge in the environmental sciences (280111)
- Expanding knowledge in the health sciences (280112)
- Other health (209999)
Publications
Dr Vincent has published 6 first-authors papers and one first-author book chapter, as well as many conference papers and non-first-author papers. Many of her fluorescent cell images have appeared around the world in science periodicals, museum displays, websites, UTas course brochures, bioscience company catalogues.
Total publications
36
Highlighted publications
(6 outputs)| Year | Type | Citation | Altmetrics |
|---|---|---|---|
| 2010 | Journal Article | Vincent AJ, Gasperini R, Foa L, Small DH, 'Astrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity', Journal of Alzheimer's Disease, 22, (3) pp. 699-714. ISSN 1387-2877 (2010) [Refereed Article] DOI: 10.3233/JAD-2010-101089 [eCite] [Details] Citations: Scopus - 65Web of Science - 63 Co-authors: Gasperini R; Foa L; Small DH | |
| 2008 | Journal Article | Vincent AJ, Lau P, Roskams AJ, 'SPARC is expressed by macroglia and microglia in the developing and mature nervous system', Developmental Dynamics, 237, (5) pp. 1449-1462. ISSN 1058-8388 (2008) [Refereed Article] DOI: 10.1002/dvdy.21495 [eCite] [Details] Citations: Scopus - 55Web of Science - 50 | |
| 2007 | Journal Article | Vincent AJ, Choi-Lundberg DL, Harris JA, West AK, Chuah MI, 'Bacteria and PAMPs activate nuclear factor κB and Gro production in a subset of olfactory ensheathing cells and astrocytes but not in Schwann cells', Glia, 55, (9) pp. 905-916. ISSN 0894-1491 (2007) [Refereed Article] DOI: 10.1002/glia.20512 [eCite] [Details] Citations: Scopus - 65Web of Science - 64 Co-authors: Choi-Lundberg DL; Harris JA; West AK; Chuah MI | |
| 2005 | Journal Article | Vincent AJ, Taylor JM, Choi-Lundberg DL, West AK, Chuah MI, 'Genetic expression profile of olfactory ensheathing cells is distinct from that of Schwann cells and astrocytes', Glia, 51, (2) pp. 132-147. ISSN 0894-1491 (2005) [Refereed Article] DOI: 10.1002/glia.20195 [eCite] [Details] Citations: Scopus - 93Web of Science - 87 Co-authors: Choi-Lundberg DL; West AK; Chuah MI | |
| 2005 | Journal Article | Vincent AJ, West AK, Chuah MI, 'Morphological and functional plasticity of olfactory ensheathing cells', Journal of Neurocytology, 34, (1-2) pp. 65-80. ISSN 0300-4864 (2005) [Refereed Article] DOI: 10.1007/s11068-005-5048-6 [eCite] [Details] Citations: Scopus - 80Web of Science - 68 Co-authors: West AK; Chuah MI | |
| 2003 | Journal Article | Vincent AJ, West AK, Chuah MI, 'Morphological Plasticity of Olfactory Ensheathing Cells Is Regulated by cAMP and Endothelin-1', Glia, 41, (4) pp. 393-403. ISSN 0894-1491 (2003) [Refereed Article] DOI: 10.1002/glia.10172 [eCite] [Details] Citations: Scopus - 72Web of Science - 65 Co-authors: West AK; Chuah MI |
Journal Article
(16 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2016 | Southam KA, Vincent AJ, Small DH, 'Do microglia default on network maintenance in Alzheimer's disease?', Journal of Alzheimer's Disease, 51, (3) pp. 657-669. ISSN 1387-2877 (2016) [Refereed Article] DOI: 10.3233/JAD-151075 [eCite] [Details] Citations: Scopus - 15Web of Science - 14 Co-authors: Southam KA; Small DH | |
| 2014 | Dawkins E, Gasperini R, Hu Y, Cui H, Vincent AJ, et al., 'The N-terminal fragment of the β-amyloid precursor protein of Alzheimer's disease (N-APP) binds to phosphoinositide-rich domains on the surface of hippocampal neurons', Journal of Neuroscience Research, 92, (11) pp. 1478-1489. ISSN 1097-4547 (2014) [Refereed Article] DOI: 10.1002/jnr.23422 [eCite] [Details] Citations: Scopus - 5Web of Science - 5 Co-authors: Dawkins E; Gasperini R; Hu Y; Cui H; Bolos M; Young KM; Foa L; Small DH | |
| 2013 | Lloyd-Burton SM, York EM, Anwar MA, Vincent AJ, Roskams AJ, 'SPARC regulates microgliosis and functional recovery following cortical ischemia', Journal of Neuroscience, 33, (10) pp. 4468-4481. ISSN 0270-6474 (2013) [Refereed Article] DOI: 10.1523/JNEUROSCI.3585-12.2013 [eCite] [Details] Citations: Scopus - 37Web of Science - 38 | |
| 2011 | Gasperini RJ, Hou X, Parkington H, Coleman H, Klaver DW, et al., 'TRPM8 and Nav 1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons', Molecular Neurodegeneration, 6, (19) pp. 1-12. ISSN 1750-1326 (2011) [Refereed Article] DOI: 10.1186/1750-1326-6-19 [eCite] [Details] Citations: Scopus - 22Web of Science - 17 Co-authors: Gasperini RJ; Klaver DW; Foa LC; Small DH | |
| 2010 | Vincent AJ, Gasperini R, Foa L, Small DH, 'Astrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity', Journal of Alzheimer's Disease, 22, (3) pp. 699-714. ISSN 1387-2877 (2010) [Refereed Article] DOI: 10.3233/JAD-2010-101089 [eCite] [Details] Citations: Scopus - 65Web of Science - 63 Co-authors: Gasperini R; Foa L; Small DH | |
| 2009 | Small DH, Gasperini R, Vincent AJ, Hung AC, Foa L, 'The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer's Disease', Journal of Alzheimer's Disease, 16, (2) pp. 225-233. ISSN 1387-2877 (2009) [Refereed Article] DOI: 10.3233/JAD-2009-0951 [eCite] [Details] Citations: Scopus - 67Web of Science - 62 Co-authors: Small DH; Gasperini R; Hung AC; Foa L | |
| 2008 | Vincent AJ, Lau P, Roskams AJ, 'SPARC is expressed by macroglia and microglia in the developing and mature nervous system', Developmental Dynamics, 237, (5) pp. 1449-1462. ISSN 1058-8388 (2008) [Refereed Article] DOI: 10.1002/dvdy.21495 [eCite] [Details] Citations: Scopus - 55Web of Science - 50 | |
| 2007 | Au E, Richter MW, Vincent AJ, Tetzlaff W, Aebersold R, et al., 'Olfactory ensheathing cell-produced SPARC modulates Schwann cell activation to promote neurite outgrowth and spinal cord repair', Journal of Neuroscience, 27, (27) pp. 7208-7221. ISSN 0270-6474 (2007) [Refereed Article] DOI: 10.1523/JNEUROSCI.0509-07.2007 [eCite] [Details] Citations: Scopus - 114Web of Science - 105 | |
| 2007 | Vincent AJ, Choi-Lundberg DL, Harris JA, West AK, Chuah MI, 'Bacteria and PAMPs activate nuclear factor κB and Gro production in a subset of olfactory ensheathing cells and astrocytes but not in Schwann cells', Glia, 55, (9) pp. 905-916. ISSN 0894-1491 (2007) [Refereed Article] DOI: 10.1002/glia.20512 [eCite] [Details] Citations: Scopus - 65Web of Science - 64 Co-authors: Choi-Lundberg DL; Harris JA; West AK; Chuah MI | |
| 2005 | Chuah MI, Vincent AJ, West AK, 'Do olfactory ensheathing cells play a role in the defense of the brain against infection?', Neuroembryology and Aging, 3, (3) pp. 152-156. ISSN 1661-3406 (2005) [Letter or Note in Journal] DOI: 10.1159/000094557 [eCite] [Details] Citations: Scopus - 3 Co-authors: Chuah MI; West AK | |
| 2005 | Vincent AJ, Taylor JM, Choi-Lundberg DL, West AK, Chuah MI, 'Genetic expression profile of olfactory ensheathing cells is distinct from that of Schwann cells and astrocytes', Glia, 51, (2) pp. 132-147. ISSN 0894-1491 (2005) [Refereed Article] DOI: 10.1002/glia.20195 [eCite] [Details] Citations: Scopus - 93Web of Science - 87 Co-authors: Choi-Lundberg DL; West AK; Chuah MI | |
| 2005 | Vincent AJ, West AK, Chuah MI, 'Morphological and functional plasticity of olfactory ensheathing cells', Journal of Neurocytology, 34, (1-2) pp. 65-80. ISSN 0300-4864 (2005) [Refereed Article] DOI: 10.1007/s11068-005-5048-6 [eCite] [Details] Citations: Scopus - 80Web of Science - 68 Co-authors: West AK; Chuah MI | |
| 2005 | Woodhouse A, Vincent AJ, Kozel MA, Chung RS, Waite PME, et al., 'Spinal cord tissue affects ensheathing cell proliferation and apoptosis', NeuroReport, 16, (7) pp. 737-740. ISSN 0959-4965 (2005) [Refereed Article] DOI: 10.1097/00001756-200505120-00016 [eCite] [Details] Citations: Scopus - 17Web of Science - 14 Co-authors: Woodhouse A; Chung RS; Vickers JC; West AK; Chuah MI | |
| 2004 | Chuah MI, Choi-Lundberg DL, Weston S, Vincent AJ, Chung RS, et al., 'Olfactory ensheathing cells promote collateral axonal branching in the injured adult rat spinal cord', Experimental Neurology, 185, (1) pp. 15-25. ISSN 0014-4886 (2004) [Refereed Article] DOI: 10.1016/j.expneurol.2003.09.008 [eCite] [Details] Citations: Scopus - 88Web of Science - 72 Co-authors: Chuah MI; Choi-Lundberg DL; Weston S; Chung RS; Vickers JC; West AK | |
| 2003 | Vincent AJ, West AK, Chuah MI, 'Morphological Plasticity of Olfactory Ensheathing Cells Is Regulated by cAMP and Endothelin-1', Glia, 41, (4) pp. 393-403. ISSN 0894-1491 (2003) [Refereed Article] DOI: 10.1002/glia.10172 [eCite] [Details] Citations: Scopus - 72Web of Science - 65 Co-authors: West AK; Chuah MI | |
| 2000 | Beattie JH, Wood AM, Trayhurn P, Jasani B, Vincent AJ, et al., 'Metallothionein is expressed in adipocytes of brown fat and is induced by catecholamines and zinc', American Journal of Physiology, 278, (4) pp. 1082-1089. ISSN 0363-6119 (2000) [Refereed Article] DOI: 10.1152/ajpregu.2000.278.4.R1082 [eCite] [Details] Citations: Web of Science - 29 Co-authors: McCormack GH; West AK |
Conference Publication
(20 outputs)| Year | Citation | Altmetrics |
|---|---|---|
| 2013 | Dawkins E, Vincent AJ, Gasperini R, Cui H, Young K, et al., 'A direct interaction of Aβ with anionic cellular lipids mediates binding to neurons (Poster)', 12th International Conference on Alzheimer's and Parkinson's Diseases, Florence, Italy (2013) [Conference Extract] Co-authors: Dawkins E; Gasperini R; Cui H; Young K; Foa L; Small DH | |
| 2012 | Dawkins EA, Gasperini R, Vincent AJ, Foa LC, Small DH, 'Analysis of Aβ cell interactions and uptake in hippocampal culture', Proceedings of the 32nd Annual Meeting of the Australian Neuroscience Society, 29 January - 1 February 2012, Gold Coast, Australia, pp. 34. (2012) [Conference Extract] Co-authors: Dawkins EA; Gasperini R; Foa LC; Small DH | |
| 2007 | Harris JA, Vincent AJ, Chuah MI, West AK, 'Pathogens induce nitric oxide production by olfactory ensheathing cells', 7th IBRO World Congress of Neuroscience, 12 - 17 July, Melbourne (2007) [Conference Extract] Co-authors: Harris JA; Chuah MI; West AK | |
| 2005 | Vincent AJ, West AK, Choi-Lundberg DL, Chuah MI, 'Whole bacteria, but not specific ligands for Toll-like receptors 2 or 4, activate NF kB and cytokine production in olfactory ensheathing cells in vitro', Society for Neuroscience (2005) [Conference Extract] Co-authors: West AK; Choi-Lundberg DL; Chuah MI | |
| 2005 | Vincent AJ, West AK, Choi-Lundberg DL, Chuah MI, 'Olfactory ensheathing cells display antimicrobial activity in culture and may contribute to the innate immune defense of the olfactory system', Proceedings of the Australian Neuroscience Society, 30 Jan - 2 Feb 2005, Perth, pp. 60. ISSN 1034-3237 (2005) [Conference Extract] Co-authors: West AK; Choi-Lundberg DL; Chuah MI | |
| 2004 | Vincent AJ, Taylor JM, Chuah MI, Chung RS, Fung SJ, et al., 'The global gene expression of olfactory ensheathing cells and comparisons to astrocytes and Schwann cells', Proceedings of the Australian Neuroscience Society, Melbourne, pp. 57. ISSN 1034-3237 (2004) [Conference Extract] Co-authors: Chuah MI; Chung RS; Fung SJ; West AK | |
| 2004 | Vincent AJ, Taylor JM, Vickers JC, West AK, Chuah MI, 'Gene expression profile of rat olfactory ensheathing cells', The International Neurotrauma Symposium, pp. 99. (2004) [Conference Extract] Co-authors: Vickers JC; West AK; Chuah MI | |
| 2004 | Vincent AJ, West AK, Chuah MI, 'A novel role for olfactory ensheathing cells in neuroimmunological defence in the rodent olfactory system', Journal of Neuroimmunology, pp. 39-49. (2004) [Conference Extract] Co-authors: West AK; Chuah MI | |
| 2004 | Vincent AJ, West AK, Chuah MI, 'A novel role for olfactory ensheathing cells in neuroimmunological defence in the rodent olfactory system', The International Neurotrauma Symposium, pp. 188. (2004) [Conference Extract] Co-authors: West AK; Chuah MI | |
| 2004 | Woodhouse A, Vincent AJ, Chung RS, Vickers JC, West AK, et al., 'Proliferation, apoptosis and migration of ensheathing cells in response to spinal cord tissue', Proceedings of the Australian Neuroscience Society, Melbourne, pp. 85. ISSN 1034-3237 (2004) [Conference Extract] Co-authors: Woodhouse A; Chung RS; Vickers JC; West AK; Chuah MI | |
| 2004 | Woodhouse A, Vincent AJ, Kozel M, Chung RS, Waite PME, et al., 'Olfactory ensheathing cells exhibit different rates of proliferation and apoptosis in the presence of uninjured and injured spinal cord tissue', The International Neurotrauma Symposium, pp. 189. (2004) [Conference Extract] Co-authors: Woodhouse A; Chung RS; Vickers JC; West AK; Chuah MI | |
| 2003 | Chung RS, Woodhouse A, Fung SJ, Vincent AJ, West AK, et al., 'Olfactory ensheathing cells promote reactive neurite sprouting in vitro through both direct and indirect mechanisms', Society for Neuroscience, November 2003, New Orleans, pp. 42.20. (2003) [Conference Extract] Co-authors: Chung RS; Woodhouse A; Fung SJ; West AK; Vickers JC; Chuah MI | |
| 2003 | Chung RS, Woodhouse A, Fung SJ, Vincent AJ, West AK, et al., 'Olfactory ensheathing cells promote reactive neurite sprouting in vitro through both direct and indirect mechanisms', Journal of Neurotrauma, USA, pp. 1099. ISSN 0897-7151 (2003) [Conference Extract] Co-authors: Chung RS; Woodhouse A; Fung SJ; West AK; Vickers JC; Chuah MI | |
| 2003 | Vincent AJ, Taylor JM, Chuah MI, Chung RS, Fung SJ, et al., 'What is an olfactory ensheathing cell? A microarray comparison of ensheathing cells, Schwann cells and astrocytes', Society for Neuroscience, November 2003, New Orleans, pp. 358.4. (2003) [Conference Extract] Co-authors: Chuah MI; Chung RS; Fung SJ; West AK | |
| 2003 | Vincent AJ, Taylor JM, Chuah MI, Chung RS, Fung SJ, et al., 'What is an olfactory ensheathing cell? A microarray comparison of ensheathing cells, Schwann cells and astrocytes', Journal of Neurotrauma, USA, pp. 1099. ISSN 0897-7151 (2003) [Conference Extract] Co-authors: Chuah MI; Chung RS; Fung SJ; West AK | |
| 2002 | Chuah MI, Choi-Lundberg DL, Weston S, Chung RS, Vincent AJ, et al., 'Encapsulated olfactory ensheathing cells in spinal cord repair', International Journal of Developmental Neuroscience, 31 Jan - 4 Feb 2002, Sydney, pp. 707. ISSN 0736-5748 (2002) [Conference Extract] Co-authors: Chuah MI; Choi-Lundberg DL; Weston S; Chung RS; West AK | |
| 2002 | Chuah MI, Choi-Lundberg DL, Weston S, Vincent AJ, Chung RS, et al., 'Olfactory ensheathing cells promote collateral axonal branching in the lesioned adult rat spinal cord', 3rd Asia Pacific Symposium on Neural Regeneration, 3-5 Dec 2002, Perth, pp. P28. (2002) [Conference Extract] Co-authors: Chuah MI; Choi-Lundberg DL; Weston S; Chung RS; West AK | |
| 2002 | Vincent AJ, West AK, Chuah MI, 'Morphological plasticity of olfactory ensheathing cells is regulated by cyclic AMP and endothelin-1', 3rd Asia Pacific Symposium on Neural Regeneration, 3-5 Dec 2002, Perth, pp. P32. (2002) [Conference Extract] Co-authors: West AK; Chuah MI | |
| 2002 | Vincent AJ, West AK, Chuah MI, 'Morphological plasticity of olfactory ensheathing cells', Proceedings of the Australian Neuroscience Society, Feb 2002, Sydney, pp. 158. ISSN 1034-3237 (2002) [Conference Extract] Co-authors: West AK; Chuah MI | |
| 2002 | Vincent AJ, West AK, Vickers JC, Chuah MI, 'Response of neurons to injury in coculture with olfactory ensheathing cells', Internal Journal of Developmental Neuroscience, 31 Jan -4 Feb 2002, Sydney, pp. 720. ISSN 0736-5748 (2002) [Conference Extract] Co-authors: West AK; Vickers JC; Chuah MI |
Grants & Funding
Dr Vincent holds a current NHMRC Research Fellowship. She has previously been awarded 3 fellowships as a postdoctoral researcher in Canada, and an Australian Postgraduate Award to support her PhD work. She obtained an Alzheimer's Australia Research grant in 2011.
Funding Summary
Number of grants
4
Total funding
Projects
- Description
- The project will create new knowledge into the role that microglia play in the development of Alzheimer's disease.
- Funding
- Dementia Australia Research Foundation Ltd ($110,000)
- Scheme
- Fellowship-Postdoctoral Fellowship in Dementia
- Administered By
- University of Tasmania
- Research Team
- Southam K; Small DH; Vincent AJ
- Period
- 2015 - 2016
- Funding
- The Select Foundation ($5,502)
- Scheme
- Grant-Small Grants Scheme
- Administered By
- University of Tasmania
- Research Team
- Dawkins EAH; Gasperini RJ; Vincent AJ
- Year
- 2012
- Funding
- Dementia Australia Research Foundation Ltd ($22,048)
- Scheme
- Grant-Seeding
- Administered By
- University of Tasmania
- Research Team
- Vincent AJ; Gasperini RJ
- Year
- 2011
- Funding
- National Health & Medical Research Council ($302,852)
- Scheme
- Fellowship-Australian Based Biomedical
- Administered By
- University of Tasmania
- Research Team
- Vincent AJ
- Period
- 2008 - 2013
- Grant Reference
- 490056
Research Supervision
Dr Vincent co-supervised one PhD candidate to completion in 2013. She has mentored many PhD, Honours and undergraduate students in the lab, beginning as a junior PhD student herself, and provided important unofficial supervision and mentoring for all the students (7) in her Canadian lab while the Principal Investigator was on study leave for 3 months.
Completed
1
Completed
| Degree | Title | Completed |
|---|---|---|
| PhD | Role of Phosphoinositides in the Biology of the Amyloid Precursor Protein Candidate: Edgar Adam Henry Dawkins | 2014 |