Profiles

Michelle Keske

Dr Michelle Anne Keske (nee Vincent)

Michelle Anne Keske (nee Vincent)

Senior Research Fellow
Menzies Institute for Medical Research

Room 436d , Medical Science 2

+61 3 6226 2669 (phone)

Michelle.Keske@utas.edu.au

Dr Keske's research focuses on the effect of pharmacological and nutritional interventions that can help prevent insulin resistance and type 2 diabetes by regulating microvascular blood flow within muscle.

Obesity, hypertension and type 2 diabetes, which are increasing to epidemic proportions in Australia, are major risk factors for cardiovascular disease. A common feature of these conditions is insulin resistance which is characterised by impaired insulin-mediated glucose metabolism in muscle.

Dr Keske's research has shown that microvascular function in muscle plays an integral role in blood glucose regulation. Insulin increases microvascular perfusion in muscle to facilitate access of glucose and insulin to the myocyte to enhance glucose disposal. Impairment in insulin-mediated microvascular perfusion in muscle can lead to insulin resistance and type 2 diabetes.

Biography

Dr Keske has been a dedicated researcher in the diabetes and cardiovascular disease field for the past 15 years. She received her PhD from the Diabetes Research Group (formerly known as the Department of Biochemistry), University of Tasmania in December 2000. During her PhD she had the opportunity to work as a visiting scholar at the University of Washington, Seattle, WA, USA. She completed 8 years of international post-doctoral training at the University of Virginia, National Institutes of Health, and Industry in the USA.

In 2007 she was recruited to join the Menzies Institute for Medical Research. She now leads a research group studying novel pharmaceutical and nutritional interventions that have the potential to prevent or reverse vascular defects in patients with diabetes and cardiovascular disease.

Career summary

Qualifications

PhD, University of Tasmania, Australia, 2000. Vascular effects of vasoconstrictors on muscle metabolism
BSc (Hons), University of Tasmania, Australia, 1994. Haemodynamic basis of insulin resistance

Memberships

Professional practice

American Diabetes Association
Australian Diabetes Society
Australian Society for Medical Research

Administrative expertise

Member of the Menzies Institute of Medical Research, UTAS (2007-ongoing)
Chair of the animal users group committee, Menzies Institute of Medical Research, UTAS (2011-2013)
Coordinator of Menzies Institute of Medical Research Seminar Series (2012-2013)
Member of the phase 2 planning committee for the Menzies Research Institute Tasmania Medical Science Building 2, UTAS
UROP selection committee (2010)
Member of the Menzies Institute of Medical Research, UTAS mentoring program (2010)
Coordinator of Human Genetics and Population Health Courses (2014-current)
Member of Menzies Institute of Medical Research Senior Management Team (2014)

Teaching

Teaching expertise

Supervise 10 week research projects for 3rd year undergraduate Biochemistry students
Ultrasound imaging practical for 3rd year undergraduate Physiology students

Teaching responsibility

Unit Coordinator for Human Genetics (CEA301) and Population Health (CEA200) – 2014 and 2015

Research Appointments

Invited expert at the Omega-3 Centre, Scientific Consensus panel in North Ryde, NSW, July 2008
Board of Directors for Diabetes Tasmania (2015-current)
Panel Member NHMRC Project Grants GRP3B (2014)
Panel Member NHMRC Project Grants GRP3C (2015)

Research Invitations

Invited presentations over past 5 years:

Methods for the investigation of flowmotion. World Congress of Microcirculation, Kyoto, Japan, Sept 2015
Exercise in the management and prevention of metabolic disease: Vascular actions of insulin and contraction in skeletal muscle. Victoria University, Melbourne, June 2015
Normal function of the skeletal muscle microvasculature and its endothelium. Exchange Symposium: Physiological Society in the UK and the European College of Sport Sciences. London, UK June 2014
Muscle microvascular blood flow responses in insulin resistance and aging. Exchange Symposium: Physiological Society in the UK and the European College of Sport Sciences. London, UK June 2014
Role of muscle blood flow on insulin action. University of Los Angeles, USA, November 2013
Can drinking tea enhance insulin sensitivity? Tasmanian Nutrition Society, Hobart, Sept 2013
Role of microvascular perfusion in insulin sensitivity. The Hobart Medical Symposium, Hobart, Australia. October 2012
Microcirculation and insulin resistance. The University of Aberdeen, Scotland, UK. June 2012
Imaging skeletal muscle microcirculation with contrast-enhanced ultrasound: diagnostic and therapeutic approaches to insulin resistance. International Conference on Clinical Research. San Francisco, CA, USA. July 2011
Does omega-3 DHA and omega-6 ARA play a role in microvascular regulation in skeletal muscle. DSM, Maryland, USA July 2011
Microcirculation and obesity. Australian and New Zealand Obesity Society. Adelaide, SA. October 2011

View more on Dr Michelle Keske in WARP

Expertise

Insulin Resistance
Type 2 diabetes
Cardiovascular Disease
Exercise
Nutrition
Ultrasound imaging

Research Themes

Dr Keske's research aligns to the University's research theme of Better Health. Obesity, hypertension and type 2 diabetes, which are increasing to epidemic proportions in Australia, are major risk factors for cardiovascular disease. A common feature of these conditions is insulin resistance which is characterised by impaired insulin-mediated glucose metabolism in muscle.

Dr Keske is researching into the vascular causes and consequences of insulin resistance. She is working on targeting the vasculature in skeletal muscle as a novel treatment target for preventing or reversing the development of insulin resistance.

Collaboration

International Collaborations

Prof Eugene Barrett, University of Virginia, Virginia, USA
Prof Jonathan Linder, Oregon Health & Science University, Oregon, USA
Assoc/Prof Melinda Moore, University of Texas Medical Branch, Texas, USA
Dr Ranganath Muniyappa, NIH, Maryland, USA
Prof Michael Quon, University of Maryland, Baltimore, Maryland, USA
Dr Dana Dawson, Aberdeen University, Scotland, UK
Prof Eric Ravussin, Pennington Biomedical Research Center, Louisiana, USA
Assoc/Prof Christian Roberts, UCLA, California, USA

National Collaborations

Prof Glenn McConell, Victoria University, Melbourne
Prof Bronwyn Kingwell, Baker IDI, Melbourne
Assoc/Prof Leonie Heilbronn, South Australian Health and Medical Research Institute, Adelaide

Awards

American Society of Echocardiography Research Award Finalist, 16th Annual Scientific Sessions, Boston, MA, USA, 2005. 'Microvascular responses to insulin are abnormal in type 2 diabetes and are reversed by ACE-inhibitor therapy: assessment of capillary recruitment by contrast ultrasound'
Quantum Leap Fellowship, University of Tasmania, 2008-2013 - $1M

Current projects

Microvascular dysfunction in adult offspring of type 2 diabetics
Role of microvascular flowmotion in skeletal muscle glucose metabolism
Cardiometabolic benefits of exercise training in type 2 diabetics independent of weight loss
Can drinking blueberry tea improve metabolic and vascular health in people with type 2 diabetes?
Sodium intake and microvascular-derived insulin resistance
Role of high fat diets on inflammation

Fields of Research

Endocrinology (320208)
Systems physiology (320803)
Cardiology (incl. cardiovascular diseases) (320101)
Peripheral nervous system (320906)
Animal physiology - systems (310910)
Medical biotechnology (320699)
Preventative health care (420605)
Nutrition and dietetics (321099)
Medical biochemistry - carbohydrates (320502)
Cell metabolism (310103)
Exercise physiology (420702)
Nutritional science (321004)
Zoology (310999)
Basic pharmacology (321401)
Medical physiology (320899)
Epidemiology (420299)
Public health nutrition (321005)
Medical biochemistry - amino acids and metabolites (320501)
Traditional, complementary and integrative medicine (420899)
Sensory systems (320907)
Geriatrics and gerontology (320210)
Proteins and peptides (340407)
Clinical pharmacology and therapeutics (321402)
Neurology and neuromuscular diseases (320905)
Central nervous system (320903)
Sports medicine (320225)
Foetal development and medicine (321501)
Animal physiology - biophysics (310908)
Neurosciences (320999)
Health services and systems (420399)

Research Objectives

Clinical health (200199)
Other health (209999)
Preventive medicine (200412)
Nutrition (200410)
Human pharmaceutical treatments (240803)
Human diagnostics (240802)
Expanding knowledge in the health sciences (280112)
Expanding knowledge in the environmental sciences (280111)
Diagnosis of human diseases and conditions (200101)
Behaviour and health (200401)
Health related to ageing (200502)
Allied health therapies (excl. mental health services) (200301)
Expanding knowledge in the biomedical and clinical sciences (280103)
Expanding knowledge in the biological sciences (280102)
Medical instruments (241002)
Health education and promotion (200203)
Aboriginal and Torres Strait Islander health system performance (210303)
Public health (excl. specific population health) (200499)

Publications

Dr Keske has published 51 papers (14 as primary author, 9 as senior author) over the course of her career in highly recognized, internationally peer reviewed journals such as Diabetes, Diabetologia, Diabetes Care, JACCI,Cardiovascular Research. Her research has been cited >2,300 times (H-index = 20) and many of her publications are rated as highly influential (9 cited >100 times; 3 cited >200 times; 1 cited >300 times).

Total publications

Journal Article

(55 outputs)

Year	Citation	Altmetrics
2022	Roberts-Thompson KM, Hu D, Russell RD, Greenaway T, Betik AC, et al., 'Impaired postprandial adipose tissue microvascular blood flow responses to a mixed-nutrient meal in first-degree relatives of adults with type 2 diabetes', American Journal of Physiology: Endocrinology and Metabolism, 323, (5) pp. E418-E427. ISSN 0193-1849 (2022) [Refereed Article] DOI: 10.1152/ajpendo.00109.2022 [eCite] [Details] Co-authors: Russell RD; Greenaway T; Richards SM; Premilovac D Tweet
2021	Russell RD, Roberts-Thomson KM, Hu D, Greenaway T, Betik AC, et al., 'Impaired postprandial skeletal muscle vascular responses to a mixed meal challenge in normoglycaemic people with a parent with type 2 diabetes', Diabetologia ISSN 0012-186X (2021) [Refereed Article] DOI: 10.1007/s00125-021-05572-7 [eCite] [Details] Citations: Scopus - 8Web of Science - 7 Co-authors: Russell RD; Greenaway T; Sharman JE; Richards SM; Rattigan S; Premilovac D Tweet
2020	Keske MA, Barrett EJ, Lindner JR, Richter EA, Liu Z, et al., 'Perfusion controls muscle glucose uptake by altering the rate of glucose dispersion in viv', American Journal of Physiology: Endocrinology and Metabolism, 318, (6) pp. E1022-E1036. ISSN 0193-1849 (2020) [Letter or Note in Journal] DOI: 10.1152/ajpendo.00430.2019 [eCite] [Details] Citations: Scopus - 4Web of Science - 4 Co-authors: Premilovac D; Richards SM; Rattigan S Tweet
2019	Bradley EA, Premilovac D, Betik AC, Hu D, Attrill EH, et al., 'Metformin improves vascular and metabolic insulin action in insulin resistant muscle', Journal of Endocrinology, 243, (2) pp. 85-96. ISSN 0022-0795 (2019) [Refereed Article] DOI: 10.1530/JOE-19-0067 [eCite] [Details] Citations: Scopus - 9Web of Science - 10 Co-authors: Bradley EA; Premilovac D; Attrill EH; Richards SM Tweet
2019	Roberts-Thomson KM, Betik AC, Premilovac D, Rattigan S, Richards SM, et al., 'Postprandial microvascular blood flow in skeletal muscle: Similarities and disparities to the hyperinsulinaemic-euglycaemic clamp', Clinical and Experimental Pharmacology and Physiology pp. 1-13. ISSN 0305-1870 (2019) [Refereed Article] DOI: 10.1111/1440-1681.13237 [eCite] [Details] Citations: Scopus - 10Web of Science - 8 Co-authors: Premilovac D; Rattigan S; Richards SM; Ross RM Tweet
2018	Hu D, Remash D, Russell RD, Greenaway T, Rattigan S, et al., 'Impairments in adipose tissue microcirculation in Type 2 diabetes mellitus assessed by real-time contrast-enhanced ultrasound', Circulation: Cardiovascular Imaging, 11, (4) Article e007074. ISSN 1942-0080 (2018) [Refereed Article] DOI: 10.1161/CIRCIMAGING.117.007074 [eCite] [Details] Citations: Scopus - 15Web of Science - 16 Co-authors: Remash D; Russell RD; Greenaway T; Rattigan S; Squibb KA; Jones G; Premilovac D; Richards SM Tweet
2018	Hu D, Russell RD, Remash D, Greenaway T, Rattigan S, et al., 'Are the metabolic benefits of resistance training in type 2 diabetes linked to improvements in adipose tissue microvascular blood flow?', American Journal of Physiology: Endocrinology and Metabolism, 315, (6) pp. E1242-E1250. ISSN 0193-1849 (2018) [Refereed Article] DOI: 10.1152/ajpendo.00234.2018 [eCite] [Details] Citations: Scopus - 3Web of Science - 3 Co-authors: Russell RD; Remash D; Greenaway T; Rattigan S; Squibb KA; Jones G; Ross RM; Premilovac D; Richards SM Tweet
2018	Premilovac D, Attrill EH, Rattigan S, Richards SM, Kim J, et al., 'Acute, local infusion of angiotensin II impairs microvascular and metabolic insulin sensitivity in skeletal muscle', Cardiovascular Research pp. 1-12. ISSN 0008-6363 (2018) [Refereed Article] DOI: 10.1093/cvr/cvy225 [eCite] [Details] Citations: Scopus - 9Web of Science - 9 Co-authors: Premilovac D; Attrill EH; Rattigan S; Richards SM Tweet
2018	Russell RD, Hu D, Greenaway T, Sharman JE, Rattigan S, et al., 'Oral glucose challenge impairs skeletal muscle microvascular blood flow in healthy people', American Journal of Physiology - Endocrinology and Metabolism, 315, (2) pp. E307-E315. ISSN 0193-1849 (2018) [Refereed Article] DOI: 10.1152/ajpendo.00448.2017 [eCite] [Details] Citations: Scopus - 23Web of Science - 24 Co-authors: Russell RD; Greenaway T; Sharman JE; Rattigan S; Richards SM Tweet
2017	Blackwood SJ, Dwyer RM, Bradley EA, Keske MA, Richards SM, et al., 'Determination of skeletal muscle microvascular flowmotion with contrast-enhanced ultrasound', Ultrasound in Medicine and Biology, 43, (9) pp. 2013-2023. ISSN 0301-5629 (2017) [Refereed Article] DOI: 10.1016/j.ultrasmedbio.2017.05.012 [eCite] [Details] Citations: Scopus - 7Web of Science - 6 Co-authors: Blackwood SJ; Dwyer RM; Bradley EA; Richards SM; Rattigan S Tweet
2017	Keske MA, Dwyer RM, Russell RD, Blackwood SJ, Brown AA, et al., 'Regulation of microvascular flow and metabolism: An overview', Clinical and Experimental Pharmacology and Physiology, 44, (1) pp. 143-149. ISSN 0305-1870 (2017) [Refereed Article] DOI: 10.1111/1440-1681.12688 [eCite] [Details] Citations: Scopus - 20Web of Science - 19 Co-authors: Dwyer RM; Russell RD; Blackwood SJ; Brown AA; Premilovac D; Richards SM; Rattigan S Tweet
2017	Ng HLH, Premilovac D, Rattigan S, Richards SM, Muniyappa R, et al., 'Acute vascular and metabolic actions of the green tea polyphenol epigallocatechin 3-gallate in rat skeletal muscle', Journal of Nutritional Biochemistry, 40 pp. 23-31. ISSN 0955-2863 (2017) [Refereed Article] DOI: 10.1016/j.jnutbio.2016.10.005 [eCite] [Details] Citations: Scopus - 9Web of Science - 9 Co-authors: Ng HLH; Premilovac D; Rattigan S; Richards SM Tweet
2017	Premilovac D, Gasperini RJ, Sawyer S, West A, Keske M, et al., 'A New Method for Targeted and Sustained Induction of Type 2 Diabetes in Rodents', Scientific Reports, 7 Article 14158. ISSN 2045-2322 (2017) [Refereed Article] DOI: 10.1038/s41598-017-14114-4 [eCite] [Details] Citations: Scopus - 18Web of Science - 17 Co-authors: Premilovac D; Gasperini RJ; Sawyer S; West A; Taylor BV; Foa L Tweet
2017	Russell RD, Hu D, Greenaway T, Blackwood SJ, Dwyer RM, et al., 'Skeletal muscle microvascular-linked improvements in glycemic control from resistance training in individuals with Type 2 Diabetes', Diabetes Care, 40, (9) pp. 1256-1263. ISSN 0149-5992 (2017) [Refereed Article] DOI: 10.2337/dc16-2750 [eCite] [Details] Citations: Scopus - 50Web of Science - 42 Co-authors: Russell RD; Greenaway T; Blackwood SJ; Dwyer RM; Sharman JE; Jones G; Squibb KA; Brown AA; Otahal P; Al-Aubaidy H; Premilovac D; Hitchins S; Richards SM; Rattigan S Tweet
2016	Climie RED, Picone DS, Keske MA, Sharman JE, 'Brachial-to-radial systolic blood pressure amplification in patients with type 2 diabetes mellitus', Journal of Human Hypertension, 30 pp. 404-409. ISSN 1476-5527 (2016) [Refereed Article] DOI: 10.1038/jhh.2015.101 [eCite] [Details] Citations: Scopus - 7Web of Science - 8 Co-authors: Climie RED; Picone DS; Sharman JE Tweet
2016	Keske MA, Premilovac D, Bradley EA, Dwyer RM, Richards SM, et al., 'Muscle microvascular blood flow responses in insulin resistance and ageing', The Journal of Physiology, 594, (8) pp. 2223-2231. ISSN 1469-7793 (2016) [Refereed Article] DOI: 10.1113/jphysiol.2014.283549 [eCite] [Details] Citations: Scopus - 45Web of Science - 47 Co-authors: Premilovac D; Bradley EA; Dwyer RM; Richards SM; Rattigan S Tweet
2016	Wagenmakers AJM, Strauss JA, Shepherd SO, Keske MA, Cocks M, 'Increased muscle blood supply and transendothelial nutrient and insulin transport induced by food intake and exercise: effect of obesity and ageing', Journal of Physiology, 594, (8) pp. 2207-2222. ISSN 0022-3751 (2016) [Refereed Article] DOI: 10.1113/jphysiol.2014.284513 [eCite] [Details] Citations: Scopus - 47Web of Science - 46 Tweet
2015	Bradley EA, Zhang L, Genders AJ, Richards SM, Rattigan S, et al., 'Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside', Cardiovascular Diabetology, 14, (1) Article 91. ISSN 1475-2840 (2015) [Refereed Article] DOI: 10.1186/s12933-015-0251-y [eCite] [Details] Citations: Scopus - 6Web of Science - 6 Co-authors: Bradley EA; Richards SM; Rattigan S Tweet
2015	Hong YH, Betik AC, Premilovac D, Dwyer RM, Keske MA, et al., 'No effect of NOS inhibition on skeletal muscle glucose uptake during in situ hindlimb contraction in healthy and diabetic Sprague-Dawley rats', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 308, (10) pp. R862-R871. ISSN 0363-6119 (2015) [Refereed Article] DOI: 10.1152/ajpregu.00412.2014 [eCite] [Details] Citations: Scopus - 10Web of Science - 10 Co-authors: Premilovac D; Dwyer RM; Rattigan S Tweet
2015	Keske MA, Ng HLH, Premilovac D, Rattigan S, Kim J, et al., 'Vascular and metabolic actions of the green tea polyphenol epigallocatechin gallate', Current Medicinal Chemistry, 22, (1) pp. 59-69. ISSN 0929-8673 (2015) [Refereed Article] DOI: 10.2174/0929867321666141012174553 [eCite] [Details] Citations: Scopus - 63Web of Science - 65 Co-authors: Ng HLH; Premilovac D; Rattigan S Tweet
2015	Picone DS, Climie RED, Ahuja KDK, Keske MA, Sharman JE, 'Brachial-to-radial SBP amplification: implications of age and estimated central blood pressure from radial tonometry', Journal of Hypertension, 33, (9) pp. 1876-1883. ISSN 0263-6352 (2015) [Refereed Article] DOI: 10.1097/HJH.0000000000000637 [eCite] [Details] Citations: Scopus - 30Web of Science - 33 Co-authors: Picone DS; Climie RED; Ahuja KDK; Sharman JE Tweet
2015	Sacre JW, Jellis CL, Haluska BA, Jenkins C, Coombs JS, et al., 'Association of exercise intolerance in type 2 diabetes with skeletal muscle blood flow reserve', JACC: Cardiovascular Imaging, 8, (8) pp. 913-921. ISSN 1936-878X (2015) [Refereed Article] DOI: 10.1016/j.jcmg.2014.12.033 [eCite] [Details] Citations: Scopus - 25Web of Science - 26 Co-authors: Marwick TH Tweet
2014	Barrett EJ, Keske MA, Rattigan S, Eringa EC, 'Rebuttal from Eugene J. Barrett, Michelle A. Keske, Stephen Rattigan and Etto C. Eringa', The Journal of physiology, 592, (23) pp. 5137-5138. ISSN 0022-3751 (2014) [Contribution to Refereed Journal] DOI: 10.1113/jphysiol.2014.284604 [eCite] [Details] Citations: Scopus - 1Web of Science - 1 Co-authors: Rattigan S Tweet
2014	Barrett EJ, Keske MA, Rattigan S, Eringa EC, 'CrossTalk proposal: De novo capillary recruitment in healthy muscle is necessary', Journal of Physiology, 592, (23) pp. 5129-5131. ISSN 0022-3751 (2014) [Refereed Article] DOI: 10.1113/jphysiol.2014.282137 [eCite] [Details] Citations: Scopus - 8Web of Science - 9 Co-authors: Rattigan S Tweet
2014	Premilovac D, Richards SM, Rattigan S, Keske MA, 'A vascular mechanism for high-sodium-induced insulin resistance in rats', Diabetologia: Clinical and Experimental Diabetes and Metabolism, 57, (12) pp. 2586-2595. ISSN 0012-186X (2014) [Refereed Article] DOI: 10.1007/s00125-014-3373-y [eCite] [Details] Citations: Scopus - 24Web of Science - 24 Co-authors: Premilovac D; Richards SM; Rattigan S Tweet
2013	Bradley EA, Richards SM, Keske MA, Rattigan S, 'Local NOS inhibition impairs vascular and metabolic actions of insulin in rat hindleg muscle in vivo', American Journal of Physiology: Endocrinology and Metabolism, 305, (6) pp. E745-E750. ISSN 0193-1849 (2013) [Refereed Article] DOI: 10.1152/ajpendo.00289.2013 [eCite] [Details] Citations: Scopus - 29Web of Science - 28 Co-authors: Bradley EA; Richards SM; Rattigan S Tweet
2013	Keith LJ, Rattigan S, Keske MA, Jose M, Sharman JE, 'Exercise aortic stiffness: Reproducibility and relation to end-organ damage in men', Journal of Human Hypertension, 27, (8) pp. 516-522. ISSN 0950-9240 (2013) [Refereed Article] DOI: 10.1038/jhh.2013.5 [eCite] [Details] Citations: Scopus - 12Web of Science - 12 Co-authors: Keith LJ; Rattigan S; Jose M; Sharman JE Tweet
2013	Premilovac D, Bradley EA, Ng HLH, Richards SM, Rattigan S, et al., 'Muscle insulin resistance resulting from impaired microvascular insulin sensitivity in Sprague Dawley rats', Cardiovascular Research, 98, (1) pp. 28-36. ISSN 0008-6363 (2013) [Refereed Article] DOI: 10.1093/cvr/cvt015 [eCite] [Details] Citations: Scopus - 33Web of Science - 31 Co-authors: Premilovac D; Bradley EA; Ng HLH; Richards SM; Rattigan S Tweet
2013	Premilovac D, Roberts-Thompson KM, Ng HLH, Bradley EA, Richards SM, et al., 'Blueberry tea enhances insulin sensitivity by augmenting insulin-mediated metabolic and microvascular responses in skeletal muscle of high fat fed rats', International Journal of Diabetology & Vascular Disease Research, 1, (8) pp. 1-10. ISSN 2328-353X (2013) [Non Refereed Article] [eCite] [Details] Co-authors: Premilovac D; Ng HLH; Bradley EA; Richards SM; Rattigan S Tweet
2013	Rattigan S, Richards SM, Keske MA, 'Microvascular contributions to insulin resistance', Diabetes, 62, (2) pp. 343-345. ISSN 0012-1797 (2013) [Contribution to Refereed Journal] DOI: 10.2337/db12-1193 [eCite] [Details] Citations: Scopus - 11Web of Science - 11 Co-authors: Rattigan S; Richards SM Tweet
2012	St-Pierre P, Keith LJ, Richards SM, Rattigan S, Keske MA, 'Microvascular blood flow responses to muscle contraction are not altered by high-fat feeding in rats', Diabetes, Obesity and Metabolism, 14, (8) pp. 753-761. ISSN 1462-8902 (2012) [Refereed Article] DOI: 10.1111/j.1463-1326.2012.01598.x [eCite] [Details] Citations: Scopus - 15Web of Science - 16 Co-authors: Keith LJ; Richards SM; Rattigan S Tweet
2010	Durham WJ, Casperson SL, Dillon EL, Keske MA, Paddon-Jones D, et al., 'Age-related anabolic resistance after endurance-type exercise in healthy humans', The FASEB Journal: (Federation of American Societies for Experimental Biology), 24, (10) pp. 4117-4127. ISSN 0892-6638 (2010) [Refereed Article] DOI: 10.1096/fj.09-150177 [eCite] [Details] Citations: Scopus - 70Web of Science - 65 Tweet
2010	St Pierre P, Genders AJ, Keske MA, Richards SM, Rattigan S, 'Loss of insulin-mediated microvascular perfusion in skeletal muscle is associated with the development of insulin resistance ', Diabetes Obesity & Metabolism, 12, (9) pp. 798-805. ISSN 1462-8902 (2010) [Refereed Article] DOI: 10.1111/j.1463-1326.2010.01235.x [eCite] [Details] Citations: Scopus - 32Web of Science - 30 Co-authors: Genders AJ; Richards SM; Rattigan S Tweet
2009	Keske MA, Clerk LH, Price WJ, Jahn LA, Barrett EJ, 'Obesity Blunts Microvascular Recruitment in Human Forearm Muscle After a Mixed Meal', Diabetes Care, 32, (9) pp. 1672-1677. ISSN 0149-5992 (2009) [Refereed Article] DOI: 10.2337/dc09-0206 [eCite] [Details] Citations: Scopus - 89Web of Science - 87 Tweet
2008	Clark MG, Rattigan S, Barrett EJ, Keske MAV, 'Point: Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise', Journal of Appliedy Physiology, 104, (3) pp. 889-891. ISSN 8750-7587 (2008) [Contribution to Refereed Journal] DOI: 10.1152/japplphysiol.00779.2007 [eCite] [Details] Citations: Scopus - 48Web of Science - 47 Co-authors: Clark MG; Rattigan S Tweet
2008	Clark MG, Rattigan S, Barrett EJ, Keske MAV, 'Last word on Point:Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise', Journal of Applied Physiology, 104, (3) pp. 900. ISSN 8750-7587 (2008) [Contribution to Refereed Journal] DOI: 10.1152/japplphysiol.01318.2007 [eCite] [Details] Citations: Scopus - 7Web of Science - 5 Co-authors: Clark MG; Rattigan S Tweet
2007	Clerk LH, Vincent MA, Barrett EJ, Lankford MF, Lindner JR, 'Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiotensin-converting enzyme inhibition ', American Journal of Physiology: Endocrinology and Metabolism, 293, (6) pp. E1804-E1809 . ISSN 0193-1849 (2007) [Refereed Article] DOI: 10.1152/ajpendo.00498.2007 [eCite] [Details] Citations: Scopus - 65Web of Science - 65 Tweet
2007	Inyard AC, Clerk LH, Vincent MA, Barrett EJ, 'Contraction stimulates nitric oxide independent microvascular recruitment and increases muscle insulin uptake ', Diabetes, 56, (9) pp. 2194-2200 . ISSN 0012-1797 (2007) [Refereed Article] DOI: 10.2337/db07-0020 [eCite] [Details] Citations: Scopus - 65Web of Science - 62 Tweet
2006	Clerk LH, Vincent MA, Jahn LA, Liu Z, Lindner JR, et al., 'Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle ', Diabetes, 55, (5) pp. 1436-1442. ISSN 0012-1797 (2006) [Refereed Article] DOI: 10.2337/db05-1373 [eCite] [Details] Citations: Scopus - 233Web of Science - 228 Tweet
2006	Vincent MA, Clerk LH, Lindner JR, Price WJ, Jahn LA, et al., 'Mixed meal and light exercise each recruit muscle capillaries in healthy humans ', American Journal of Physiology: Endocrinology and Metabolism, 290, (6) pp. E1191-E1197. ISSN 0193-1849 (2006) [Refereed Article] DOI: 10.1152/ajpendo.00497.2005 [eCite] [Details] Citations: Scopus - 139Web of Science - 145 Tweet
2005	Marro KI, Hyyti OM, Vincent MA, Kushmerick MJ, 'Validation and advantages of FAWSETS perfusion measurements in skeletal muscle ', N M R in Biomedicine: (Nuclear Magnetic Resonance), 18, (4) pp. 226-234. ISSN 0952-3480 (2005) [Refereed Article] DOI: 10.1002/nbm.950 [eCite] [Details] Citations: Scopus - 12Web of Science - 10 Tweet
2005	Vincent MA, Clerk LH, Barrett E, Lankford MF, Lindner JR, 'Microvascular responses to insulin are abnormal in type 2 diabetes and are reversed by ACE-inhibitor therapy: assessment of microvascular recruitment by contrast ultrasound', American Society of Echocardiography. Journal, 18 pp. 500. ISSN 0894-7317 (2005) [Contribution to Refereed Journal] [eCite] [Details]
2005	Vincent MA, Clerk LH, Rattigan S, Clark MG, Barrett EJ, 'Active role for the vasculature in the delivery of insulin to skeletal muscle', Clinical and Experimental Pharmacology and Physiology, 32, (4) pp. 302-307. ISSN 0305-1870 (2005) [Refereed Article] DOI: 10.1111/j.1440-1681.2005.04188.x [eCite] [Details] Citations: Scopus - 57Web of Science - 54 Co-authors: Rattigan S Tweet
2004	Clerk LC, Vincent MA, Lindner J, Clark MG, Rattigan S, et al., 'The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake', Diabetes/Metabolism Reseach and Reviews, 20, (1) pp. 3-12. ISSN 1520-7552 (2004) [Refereed Article] DOI: 10.1002/dmrr.414 [eCite] [Details] Citations: Scopus - 89Web of Science - 81 Co-authors: Clark MG; Rattigan S Tweet
2004	Vincent MA, Clerk LH, Lindner JR, Klibanov AL, Clark MG, et al., 'Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo', Diabetes, 53, (6) pp. 1418-1423. ISSN 0012-1797 (2004) [Refereed Article] DOI: 10.2337/diabetes.53.6.1418 [eCite] [Details] Citations: Scopus - 333Web of Science - 323 Co-authors: Clark MG; Rattigan S Tweet
2004	Zhang L, Vincent MA, Richards SM, Clerk LH, Rattigan S, et al., 'Insulin sensitivity of muscle capillary recruitment in vivo', Diabetes, 53, (2) pp. 447-453. ISSN 0012-1797 (2004) [Refereed Article] DOI: 10.2337/diabetes.53.2.447 [eCite] [Details] Citations: Scopus - 143Web of Science - 135 Co-authors: Zhang L; Richards SM; Rattigan S; Clark MG Tweet
2003	Clark MG, Wallis MG, Barrett EJ, Vincent MA, Richards SM, et al., 'Blood flow and muscle metabolism: a focus on insulin action', American Journal of Physiology: Endocrinology and Metabolism, 284, (2) pp. E241-E258. ISSN 0193-1849 (2003) [Refereed Article] DOI: 10.1152/ajpendo.00408.2002 [eCite] [Details] Citations: Web of Science - 276 Co-authors: Clark MG; Richards SM; Rattigan S Tweet
2003	Vincent MA, Barrett EJ, Lindner JR, Clark MG, Rattigan S, 'Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin', American Journal of Physiology: Endocrinology and Metabolism, 285, (1 48-1) pp. E123-E129. ISSN 0193-1849 (2003) [Refereed Article] DOI: 10.1152/ajpendo.00021.2003 [eCite] [Details] Citations: Scopus - 258Web of Science - 249 Co-authors: Clark MG; Rattigan S Tweet
2003	Vincent MA, Montagnani M, Quon MJ, 'Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium', Current Diabetes Reports, 3, (4) pp. 279-288. ISSN 1534-4827 (2003) [Refereed Article] DOI: 10.1007/s11892-003-0018-9 [eCite] [Details] Citations: Scopus - 198 Tweet
2001	Keske MAV, Rattigan S, Clark MG, 'Size-Dependent Effects of Microspheres on Vasoconstrictor-Mediated Change in Oxygen Uptake by Perfused Rat Hindlimb', Microvascular Research, 62, (3) pp. 306-314. ISSN 0026-2862 (2001) [Refereed Article] DOI: 10.1006/mvre.2001.2344 [eCite] [Details] Citations: Scopus - 2Web of Science - 2 Co-authors: Rattigan S; Clark MG Tweet
2001	Keske MAV, Rattigan S, Clark MG, Bernard SL, Glenny RW, 'Spatial Distribution of Nutritive and Nonnutritive Vascular Routes in Perfused Rat Hindlimb Muscle Using Microspheres', Microvascular Research, 61, (1) pp. 111-121. ISSN 0026-2862 (2001) [Refereed Article] DOI: 10.1006/mvre.2000.2278 [eCite] [Details] Citations: Scopus - 4Web of Science - 3 Co-authors: Rattigan S; Clark MG Tweet
2000	Clark MG, Rattigan S, Clerk LH, Keske MAV, Clark AD, et al., 'Nutritive and non-nutritive blood flow: rest and exercise', Acta Physiologica Scandinavica, 168, (4) pp. 519-530. ISSN 0001-6772 (2000) [Refereed Article] DOI: 10.1046/j.1365-201X.2000.00704.x [eCite] [Details] Citations: Scopus - 67Web of Science - 64 Co-authors: Clark MG; Rattigan S; Clark AD; Newman JMB Tweet
2000	Griffiths CD, Keske MAV, Szallasi A, Colquhoun EQ, Geraghty DP, 'Functional and desensitizing effects of the novel synthetic vanilloid-like agent 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) in the perfused rat hindlimb', British Journal of Pharmacology, 131, (7) pp. 1408-1412. ISSN 0007-1188 (2000) [Refereed Article] DOI: 10.1038/sj.bjp.0703702 [eCite] [Details] Citations: Scopus - 2Web of Science - 1 Co-authors: Griffiths CD; Colquhoun EQ; Geraghty DP Tweet
1999	Youd JM, Newman JMB, Clark MG, Appleby GJ, Rattigan S, et al., 'Increased metabolism of infused 1-methylxanthine by working muscle', Acta Physiologica Scandinavica, 166, (4) pp. 301-308. ISSN 0001-6772 (1999) [Refereed Article] DOI: 10.1046/j.1365-201x.1999.00572.x [eCite] [Details] Citations: Scopus - 14Web of Science - 17 Co-authors: Newman JMB; Clark MG; Appleby GJ; Rattigan S Tweet
1998	Keske MAV, Rattigan S, Clark MG, 'Microsphere infusion reverses vasoconstrictor-mediated changes in hindlimb oxygen uptake and energy status', Acta Physiologica Scandinavica, 164, (1) pp. 61-70. ISSN 0001-6772 (1998) [Refereed Article] DOI: 10.1046/j.1365-201X.1998.00408.x [eCite] [Details] Citations: Scopus - 10Web of Science - 10 Co-authors: Rattigan S; Clark MG Tweet

Chapter in Book

(4 outputs)

Year	Citation	Altmetrics
2013	Premilovac D, Ng HLH, Richards SM, Bradley EA, Dwyer RM, et al., 'Role for the Microvasculature in Glucose Uptake in Skeletal Muscle', Glucose Uptake: Regulation, Signaling Pathways and Health Implications (Endocrinology Research and Clinical Developments), Nova Science Publishers, Johnson CC and Williams DB (ed), New York, pp. 109-139. ISBN 978-1-62618-670-5 (2013) [Research Book Chapter] [eCite] [Details] Co-authors: Premilovac D; Ng HLH; Richards SM; Bradley EA; Dwyer RM; Rattigan S Tweet
2000	Clark MG, Keske MAV, 'Preparation and properties of isolated hepatocytes from sheep', The Hepatocyte Review, Kluwer Academic Publishers, Berry, Michael N., and Edwards, Anthony M. (ed), Dordrecht, NL, pp. 25-34. ISBN 0-7923-6177-6 (2000) [Research Book Chapter] [eCite] [Details] Co-authors: Clark MG
1998	Clark MG, Rattigan S, Dora KA, Newman JMB, Keske MAV, 'Interaction between blood flow, metabolism and exercise', Biochemistry of Exercise X, Human Kinetics, M Hargreaves & M Thompson (ed), Champaign, pp. 35-46. ISBN 0-88011-758-3 (1998) [Research Book Chapter] [eCite] [Details] Co-authors: Clark MG; Rattigan S; Dora KA; Newman JMB
1997	Clark MG, Rattigan S, Dora KA, Newman JMB, Steen JT, et al., 'Vascular and metabolic regulation of muscle', Physiology, Stress and Malnutrition, Lippincott-Raven, Kinney, JM & Tucker, HN (ed), Philadelphia, pp. 325-346. ISBN 0-397-58763-5 (1997) [Research Book Chapter] [eCite] [Details] Co-authors: Clark MG; Rattigan S; Dora KA; Newman JMB; Steen JT; Miller KAL

Conference Publication

(8 outputs)

Year	Citation	Altmetrics
2016	Hu Donghua, Russell RD, Sharman JE, Rattigan S, Jacobson GA, et al., 'Effect of blueberry tea on improving metabolic and vascular function in people with and without type 2 diabetes - A Pilot Study', Australian Diabetes Society and Australian Diabetes Educators Association Annual Scientific Meeting 2016, 24-26 August, 2016, Gold Coast, Australia (2016) [Conference Extract] [eCite] [Details] Co-authors: Russell RD; Sharman JE; Rattigan S; Jacobson GA; Al-Aubaidy HAM; Richards SM
2014	Pirie AD, Ahuja KDK, Jacobson GA, Geraghty DP, Narkowicz CK, et al., 'Glucose tolerance is improved by supplementation with carpobrotus rossii flavanoids in insulin resistant mice', Thirty-Eighth Annual Scientific Meeting of The Nutrition Society of Australia, 26 - 28 November, 2014, Hobart, Tasmania (2014) [Conference Extract] [eCite] [Details] Co-authors: Pirie AD; Ahuja KDK; Jacobson GA; Geraghty DP; Narkowicz CK
2011	Newman JMB, Dwyer RM, Keske MAV, Richards SM, Rattigan S, 'Flow motion in skeletal muscle is associated with increased nutritive flow and insulin action', Proceedings of the 71st Scientific Sessions of the American Diabetes Association, 24-28 June, San Diego, California, pp. 1740-P. (2011) [Conference Extract] [eCite] [Details] Co-authors: Newman JMB; Dwyer RM; Richards SM; Rattigan S
2011	Rattigan S, Newman JMB, Dwyer RM, Richards S, Keske MAV, 'Flow motion in skeletal muscle microvasculature is associated with increased nutritive flow', Australia and New Zealand Microcirculation Society Conference, 30 Nov - 3 Dec, Western Australia (2011) [Conference Extract] [eCite] [Details] Co-authors: Rattigan S; Newman JMB; Dwyer RM
2001	Keske MAV, Rattigan S, Clark MG, Barrett EJ, 'Inhibition of nitric oxide synthase prevents insulin-stimulated capillary recruitment and glucose uptake in skeletal muscle in vivo', Diabetes, vol 50, Supplement 2, June 22-26, 2001, Philadelphia, pp. A334. ISSN 0012-1797 (2001) [Conference Extract] [eCite] [Details] Co-authors: Rattigan S; Clark MG
1997	Newman JMB, Clark MG, Rattigan S, Appleby GJ, Keske MAV, et al., 'Effect of Muscle Contraction on Metabolism of 1-Methylxanthine and L-Arginine in the Constant-Flow Perfused Rat Hindlimb', 10th International Conference on the Biochemistry of Exercise, Sydney, pp. 76. (1997) [Conference Extract] [eCite] [Details] Co-authors: Newman JMB; Clark MG; Rattigan S; Appleby GJ
1997	Youd JM, Rattigan S, Keske MAV, Clark MG, 'Sciatic Nerve Severance Produces Haemodynamic Changes and Insulin Resistance in Muscle', Diabetologia, Helsinki, pp. A257. (1997) [Conference Extract] [eCite] [Details] Co-authors: Rattigan S; Clark MG
1996	Steen JT, Keske MAV, Clark MG, 'Resting muscle thermogenesis: novel mechanisms', Tenth International Hibernation Symposium, Cradle Mountain, Tasmania, pp. 305-310. (1996) [Non Refereed Conference Paper] [eCite] [Details] Co-authors: Steen JT; Clark MG

Thesis

(1 outputs)

Year	Citation	Altmetrics
2000	Keske MAV, 'Vascular effects of vasoconstrictors on muscle metabolism' (2000) [PhD] [eCite] [Details]

Grants & Funding

Since 2008 Dr Keske has obtained $3.3M in competitive grant funding to support her independent research program. $1M Quantum Leap Fellowship; $390k ARC Discovery Grant; $1.4M NHMRC Project Grants; $129k Heart Foundation Australia, $100k other local Tasmania Funds.

Funding Summary

Number of grants

Total funding

$3,135,954

Projects

Can anti-diabetic agents improve blood flow and outcome following stroke in type 2 diabetes? (2018)$24,912

Description: People with type 2 diabetes are four times more likely to have a stroke. Interestingly, common anti-diabetic drugs seem to improve patient outcomes following a stroke. This project will determine whether anti-diabetic drugs improve brain blood flow dynamics during and after stroke to reduce stroke severity in an animal model of type 2 diabetes.
Funding: Royal Hobart Hospital Research Foundation ($24,912)
Scheme: Grant-Minor Project
Administered By: University of Tasmania
Research Team: Premilovac D; Sutherland BA; Burgess JR; Howells DW; Foa LC; Keske MAV
Year: 2018

Mixed Meal Challenge A new diagnostic test for screening pre diabetes (2016)$24,225

Description: The oral glucose tolerance test (GTT) is the gold standard for assessing pre-diabetes and type 2 diabetes (T2D), and is used world-wide. However, our researchgroup has made an important discovery demonstrating the GTT causes acute microvascular insulin resistance in healthy people. These findings have asignificant clinical impact as it implies that the GTT does not have the sensitivity to identify people with vascular-derived insulin resistance which is one of theearliest events in the development of pre-diabetes. Therefore, people with vascular‐derived insulin resistance are not being identified or diagnosed. We have developed an alternative test (the mixed meal challenge; MMC) and hypothesise it will have greater capacity to screen for pre-diabetes.Aim 1: Determine whether the MMC can identify pre-diabetes in a population of people that would otherwise be considered healthy in response to a GTT.Aim 2: Determine whether the benefits of the MMC as a new diagnostic test is linked to microvascular insulin sensitivity in skeletal muscle.
Funding: Royal Hobart Hospital Research Foundation ($24,225)
Scheme: Grant-Establishment
Administered By: University of Tasmania
Research Team: Keske MAV; Greenaway TM; Rattigan S; Russell RD; Neilson S
Year: 2016

Promoting regrowth of nerve fibres into the epidermis during diabetic neuropathy by LRP agonists (2015 - 2017)$413,731

Funding: National Health & Medical Research Council ($413,731)
Scheme: Grant-Project
Administered By: University of Tasmania
Research Team: Foa LC; Taylor BVM; West AK; Keske MAV
Period: 2015 - 2017
Grant Reference: 1088952

Microvascular dysfunction in adult offspring of type 2 diabetics (2014)$20,294

Description: Offspring from type 2 diabetics (T2D) are at much greater risk of developing diabetes than a person with no family history. The mechanism for this increase in risk is not known. This project will determine whether microvascular dysfunction in skeletal muscle and skin of first degree relatives with T2D occurs before development of insulin resistance. We will recruit people with and without family history of T2D. It will measure microvascular actions (using ultrasound) in these people before and after a mixed meal challenge. The outcomes of this study will determine whether monitoring microvasculature responses in muscle is an important 'early' strategy for assessing risk that might inform patient treatment to prevent or delay progression to insulin resistance or T2D.
Funding: Royal Hobart Hospital Research Foundation ($20,294)
Scheme: Grant-Clinical Research
Administered By: University of Tasmania
Research Team: Keske MAV; Rattigan S; Sharman JE; Russell R; Premilovac D
Year: 2014

Cardiometabolic benefits of exercise training in type 2 diabetes independent of weight loss (2014)$50,735

Description: This project will recruit an overweight type 2 diabetes cohort, medically assessed for an exercise program. It aims to recruit some with family history of type 2 diabetes and some without. The cohort with exercise test before and after 6 weeks of the exercise program, with type 2 medications discontinued before test. The aim is to show that heart health will not be as good with family history of type 2 and that exercise will improve heart health but will be of more benefit to those with a family history than those without.
Funding: University of Tasmania ($50,735)
Scheme: null
Administered By: University of Tasmania
Research Team: Keske MAV; Greenaway T; Marwick TH; Ross RM; Rattigan S; Sharman JE; Premilovac D
Year: 2014

The physiological benefits of anthocyanins as a functional food (2013)$7,500

Description: The overall aim of this project is to investigate the impact and to contribute to the evidence base for anthocyanins as a functional food.
Funding: Fruit Growers Tasmania Inc ($7,500)
Scheme: Contract Research
Administered By: University of Tasmania
Research Team: Walls JT; Geraghty DP; Keske MAV; Blackhall ML
Year: 2013

Role of microvascular flowmotion in skeletal muscle glucose metabolism (2013 - 2015)$576,533

Description: Obesity and type 2 diabetes are nationally and globally reaching epidemic rates. This project investigates the regulation of blood flow within muscle and its impact on metabolism. Outcomes from the study may lead to diagnostic tools and treatments for cardiovascular disease associated with obesity, hypertension and type 2 diabetes.
Funding: National Health & Medical Research Council ($576,533)
Scheme: Grant-Project
Administered By: University of Tasmania
Research Team: Rattigan S; Keske MAV; Richards SM; Ross RM
Period: 2013 - 2015
Grant Reference: 1043474_HF

Neural regulation of skeletal muscle insulin sensitivity (2012)$9,825

Funding: The Select Foundation ($9,825)
Scheme: Grant-Small Grants Scheme
Administered By: University of Tasmania
Research Team: Rattigan S; Keske MAV; Dickson TC
Year: 2012

Adipose tissue blood flow: the link between obesity and disease risk? (2012)$7,580

Funding: The Select Foundation ($7,580)
Scheme: Grant-Small Grants Scheme
Administered By: University of Tasmania
Research Team: Richards SM; Keske MAV
Year: 2012

Actions of the polyphenol epigallocatechin 3-gallate on insulin sensitivity (2011 - 2013)$395,518

Funding: National Health & Medical Research Council ($395,518)
Scheme: Grant-Project
Administered By: University of Tasmania
Research Team: Keske MAV; Rattigan S; Quon M
Period: 2011 - 2013
Grant Reference: 1009962

Metabolic and vascular actions of EGCG on insulin sensitivity (2011 - 2013)$15,000

Funding: Diabetes Tasmania ($15,000)
Scheme: Scholarship
Administered By: University of Tasmania
Research Team: Keske MAV
Period: 2011 - 2013

Microvascular Defects and Insulin Resistance (2011 - 2012)$127,490

Funding: Heart Foundation ($127,490)
Scheme: Grant-In-Aid
Administered By: University of Tasmania
Research Team: Rattigan S; Keske MAV; Richards SM
Period: 2011 - 2012

Quantum Leap Fellowship (2008 - 2012)$1,000,000

Funding: Menzies Research Institute Tasmania / University of Tasmania ($1,000,000)
Scheme: Fellowship
Administered By: Menzies Research Institute Tasmania
Research Team: Keske MAV
Period: 2008 - 2012

NHMRC Standard Equipment Grant - 2008 (2008)$72,611

Funding: National Health & Medical Research Council ($72,611)
Scheme: Grant-Equipment
Administered By: University of Tasmania
Research Team: Keske MAV; Rattigan S; Richards SM
Year: 2008
Grant Reference: 580023

Blood Flow Routes in Muscle (2008 - 2010)$390,000

Funding: Australian Research Council ($390,000)
Scheme: Grant-Discovery Projects
Administered By: University of Tasmania
Research Team: Keske MAV; Rattigan S
Period: 2008 - 2010
Grant Reference: DP0877385

Research Supervision

Since 2008 Dr Keske has supervised 2 post-doctoral fellows, 1 research assistant, 4 PhD and 11 Honours candidates (current supervision 1 post-doctoral fellow and 3 PhD candidates).

Completed

Degree	Title	Completed
PhD	Assessment of Citrus Bioflavonoid and Phytosterol Supplements for Dipeptidyl Peptidase-4 Inhibitory Activity Candidate: Ankit Gupta	2020
PhD	Role of Adipose Tissue Microvascular Blood Flow in Type 2 Diabetes Candidate: Donghua Hu	2018
PhD	Inflammation is Not a Contributing Factor in the Development of Insulin Resistance in Diet Induced Obesity in Rats Candidate: Aascha Adriana Brown	2017
PhD	Characterisation of Flowmotion in Healthy Controls and Type 2 Diabetes Candidate: Sarah Joan Blackwood	2017
PhD	The Pharmaceutical and Nutraceutical Potential of the Halophytic Plant Carpobrotus rossii Candidate: Adam Douglas Pirie	2014
PhD	Effect of the Green Tea Polyphenol, EGCG, on Insulin Sensitivity Candidate: Huei Leng Helena Ng	2014
PhD	Microvascular Dysfunction and the Development of Muscle Insulin Resistance Candidate: Dino Premilovac	2012