DNA repair and mutagenesis - The Ambrose Group
We are interested in the regulation of error-prone DNA polymerases in bacteria, yeast, and humans.
In particular, we use conventional mutation detection assays along with whole genome and proteome interrogation methodologies to investigate how overall cellular physiology impacts upon the generation of mutations in bacterial, yeast, and human cells.
Expertise
- Microbial genetics and physiology
- Cellular and Molecular Biology
- DNA repair and mutagenesis assays
- Gene expression and protein profiling
Projects
Regulation of antibiotic resistance mutations in Pseudomonas aeruginosa
Damage signalling and regulation of translesion synthesis DNA polymerases in Saccharomycescerevisiae
Mitochondrial DNA damage, repair and mutagenesis in yeast and human model systems
Group Leader(s)
Affiliation
Biomedical Sciences
School of Medicine
Contact
Email: Mark.Ambrose@utas.edu.au