2D and 3D Epigenomic Remodelling - The Taberlay Group
My lab has an avid interest in distal regulatory elements and three-dimensional aspects of gene control, which developed after discovering a critical role for enhancers in cellular reprogramming. Central to this interest is understanding the importance of enhancers and insulators and what they contribute to the normal cellular processes, disease initiation and progression. We use cutting-edge epigenomic methods (DNA methylation and nucleosome positioning, chromatin interaction assays and chromatin immunoprecipitation) and bioinformatic analyses to address key questions concerning epigenetic reprogramming in prostate and breast cancers, and neurodegenerative disorders such as Alzheimer's disease.
Expertise
- Epigenomics
- Epigenetics
- Epigenetic Mechanisms
- Chromatin
- Molecular Biology
- Next-Generation Sequencing
- Assay Development
- Genomics
- Computational Biology
- Development
- Cancer
- Alzheimer’s Disease
Projects
Charting Epigenetic Reprogramming in Alzheimer's Disease
The Fundamental Role of Nucleosomes in Driving Aberrant Epigenetic Signatures
Mapping Epigenomic Information in a Three-Dimensional Prostate Cancer Cell Environment
Epigenetic Regulation of SMARCA4 and ARID1A in Prostate Cancer
Identifying Critical Neuronal Signatures of Epigenetic Modifier Complexes and Telomere Length Alterations in Human Alzheimer’s Disease
Group Leader(s)
Affiliation
Biomedical Sciences
School of Medicine
Contact
Email: Phillippa.Taberlay@utas.edu.au
Group members
Aparna Raina
Thomas Halbe
Thalia Perez-Suarez
Dr. Katherine Giles
Shannon Huskins
Alex Woodworth