2D and 3D Epigenomic Remodelling - The Taberlay Group

We aim to understand the molecular epigenetic principles of cellular control in normal and disease states, and the role of chromatin in 2D and 3D nuclear space.

My lab has an avid interest in distal regulatory elements and three-dimensional aspects of gene control, which developed after discovering a critical role for enhancers in cellular reprogramming. Central to this interest is understanding the importance of enhancers and insulators and what they contribute to the normal cellular processes, disease initiation and progression. We use cutting-edge epigenomic methods (DNA methylation and nucleosome positioning, chromatin interaction assays and chromatin immunoprecipitation) and bioinformatic analyses to address key questions concerning epigenetic reprogramming in prostate and breast cancers, and neurodegenerative disorders such as Alzheimer's disease.

Expertise

Epigenomics
Epigenetics
Epigenetic Mechanisms
Chromatin
Molecular Biology
Next-Generation Sequencing
Assay Development
Genomics
Computational Biology
Development
Cancer
Alzheimer’s Disease

Projects

Charting Epigenetic Reprogramming in Alzheimer's Disease

The Fundamental Role of Nucleosomes in Driving Aberrant Epigenetic Signatures

Mapping Epigenomic Information in a Three-Dimensional Prostate Cancer Cell Environment

Epigenetic Regulation of SMARCA4 and ARID1A in Prostate Cancer

Identifying Critical Neuronal Signatures of Epigenetic Modifier Complexes and Telomere Length Alterations in Human Alzheimer’s Disease

Group Leader(s)

Dr Phillippa Taberlay

Affiliation

Biomedical Sciences

School of Medicine

Contact

Email: Phillippa.Taberlay@utas.edu.au

Group members

Aparna Raina

Thomas Halbe

Thalia Perez-Suarez

Dr. Katherine Giles

Shannon Huskins

Alex Woodworth